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Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium

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https://www.readbyqxmd.com/read/29991463/a-single-dose-of-magnesium-as-well-as-chronic-administration-enhances-long-term-memory-in-novel-object-recognition-test-in-healthy-and-acth-treated-rats
#1
Vedrana Đurić, Bojan Batinić, Jelena Petrović, Dušanka Stanić, Zorica Bulat, Vesna Pešić
Although a magnesium-mediated attenuation of memory deficits was reported in animal models of ageing and traumatic brain injury, a possible memory enhancement in healthy subjects has not been investigated yet. We used novel object recognition test (NORT) to examine the effects of acute (30 mg/kg) and chronic (50 mg/kg, 28 days) Mg-sulfate treatment on the long-term memory (LTM) in healthy adult male rats, and to test the sustainability of magnesium effects in the models of acute and chronic (21 days) ACTH administration (10 μg/animal), mimicking the stress- and depression-like conditions...
July 10, 2018: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/29991461/down-regulation-of-magnesium-transporting-molecule-claudin-16-as-a-possible-cause-of-hypermagnesiuria-with-the-development-of-tubulo-interstitial-nephropathy
#2
Taisuke Shimizu, Kaori Takayanagi, Takatsugu Iwashita, Akira Ikari, Naohiko Anzai, Shimpei Okazaki, Hiroaki Hara, Minoru Hatano, Tatsuro Sano, Tomonari Ogawa, Koichi Kanozawa, Hajime Hasegawa
Tubulo-interstitial nephropathy (TIN) is a critical pathological setting for the renal prognosis, and an increase in the urine magnesium excretion is a well-known characteristic feature as one of clinical parametets for the assessment of TIN. We examined the correlation between the development of TIN and the changes in the mRNA expression of renal magnesium-transporting molecules in rats with unilateral ureter obstruction (UUO). Ureter-ligated kidney was sampled at day-0 (control), day-1 (early phase) and day-7 (late phase)...
July 10, 2018: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/29637898/a-6-month-follow-up-of-disability-quality-of-life-and-depressive-and-anxiety-symptoms-in-pediatric-migraine-with-magnesium-prophylaxis
#3
Gordana Kovacevic, Dejan Stevanovic, Dragana Bogicevic, Dimitrije Nikolic, Slavica Ostojic, Biljana Vucetic Tadic, Blažo Nikolic, Ivana Bosiocic, Nikola Ivancevic, Kristina Jovanovic, Janko Samardzic, Jasna Jancic
Magnesium is frequently used for pediatric migraine prophylaxis. The aim of this study was to evaluate to which extent the disability levels, quality of life (QOL), and anxiety and depressive symptoms change after 6-month magnesium prophylaxis in pediatric migraine. This is a follow-up study of 34 children aged 7-17 years with migraine treated with oral magnesium. Disability due to migraine was assessed by the Pediatric Migraine Disability Assessment tool (PedMIDAS), QOL was assessed by the KIDSCREEN-27, and anxiety and depressive symptoms were assessed by the Revised Child Anxiety and Depression Scale (RCADS)...
November 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/29637897/the-effect-of-magnesium-supplementation-on-muscle-fitness-a-meta-analysis-and-systematic-review
#4
Ru Wang, Cheng Chen, Wei Liu, Tang Zhou, Pengcheng Xun, Ka He, Peijie Chen
Increasing evidence supports a role of magnesium (Mg) in skeletal muscle function. However, no systematic review or meta-analysis has summarized data on Mg supplementation in relation to muscle fitness in humans. Thus, this study aimed to quantitatively assess the effect of Mg supplementation on muscle fitness. A meta-analysis and systematic review. Medline database and other sources were searched for randomized clinical trials through July 2017. Studies that reported results regarding at least one of the following outcomes: leg strength, knee extension strength, peak torque, muscle power, muscle work, jump, handgrip, bench press weights, resistant exercise, lean mass, muscle mass, muscle strength, walking speed, Repeated Chair Stands, and TGUG were included...
November 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/29637896/effect-of-urine-ph-and-magnesium-on-calcium-oxalate-saturation
#5
Silvia Ferrè, Jacob S Grange, Beverley Adams-Huet Ms, Orson W Moe, Naim M Maalouf
Hypomagnesiuria is a common biochemical finding in patients with calcium oxalate (CaOx) nephrolithiasis. Clinical trials using Mg supplements as therapy against CaOx stones have shown mixed results. We tested the effect of Mg administration in healthy subjects under conditions of controlled urine pH (UpH) on urinary Ca excretion rate (UCaV) and CaOx saturation. This is a 4-phase, double blind, placebo-controlled, metabolic crossover study performed in healthy volunteers. Mg lactate (MgLact2 ) was used as Mg supplement...
November 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/29637895/jean-durlach-1925-2017
#6
Yves Rayssiguier
No abstract text is available yet for this article.
November 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/29256409/magnesium-deficiency-affects-hnf1%C3%AE-expression-in-rat-liver-in-vivo-and-in-vitro
#7
Hélène Martin, Delphine Antoine, Lise Coste-Sarguet, Fatimata Seydou Sarr, Lysiane Richert, Alain Berthelot
Hepatocyte nuclear factor 1β (HNF1β) is a transcription factor that is involved in embryonic development and tissue-specific gene expression in several organs, including the kidney and the liver. HNF1β mutations are associated with hypomagnesemia and renal magnesium wasting; however, to date, the exact molecular mechanism involved in this regulation is unclear. Furthermore, it is not known whether the Mg concentration could per se participate to this regulation by modifying HNF1β expression. We have studied in rats the effects of a 6-week diet with deficient or supplemented Mg concentrations compared to a diet with a standard Mg concentration on HNF1β protein expression...
August 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/29256408/magnesium-enhances-the-beneficial-effects-of-nk1-antagonist-administration-on-blood-brain-barrier-permeability-and-motor-outcome-after-traumatic-brain-injury
#8
Joshua L Ameliorate, Mounir N Ghabriel, Robert Vink
The current study investigated whether adding magnesium to an NK1 tachykinin receptor antagonist after traumatic brain injury would enhance efficacy to further reduce blood-brain barrier permeability and improve functional recovery compared to either treatment alone. Sprague-Dawley rats were injured using the impact acceleration model of diffuse brain injury, and received either no treatment, MgSO4 (30 mg/kg IV), the NK1 antagonist n-acetyl L tryptophan (2.5 mg/kg IP), or both agents combined. Animals were then killed at either 1, 5, or 24 h postinjury for determination of blood-brain barrier permeability using previously administered Evans blue dye or assessed for functional outcome over a 1-week period using the rotarod motor test...
August 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/29256407/effect-of-oral-magnesium-supplementation-on-the-transcription-of-trpm6-trpm7-and-slc41a1-in-individuals-newly-diagnosed-of-pre-hypertension-a-randomized-double-blind-placebo-controlled-trial
#9
Mariana Rodríguez-Ramírez, Martha Rodríguez-Morán, Miguel A Reyes-Romero, Fernando Guerrero-Romero
A stringent regulation of influx and efflux of magnesium by cation transporters seems to play an important role in the regulation of blood pressure (BP). With this regard, we evaluate the effect of oral magnesium supplementation on the transcription of TRPM6, TRPM7, and SLC41A1, in individuals with incident pre-hypertension (preHTN). For such purpose, we conducted a randomized, double-blind, placebo-controlled trial that compared 18 individuals who received oral magnesium lactate (360 mg elemental magnesium) versus 18 individuals who received placebo, during 4 months...
August 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/29256406/magnesium-supplementation-affects-gene-expression-related-to-insulin-and-lipid-in-patients-with-gestational-diabetes
#10
Mehri Jamilian, Mansooreh Samimi, Afshar Ebrahimi Faraneh, Esmat Aghadavod, Hashemi Dizaji Shahrzad, Maryam Chamani, Alireza Mafi, Zatollah Asemi
Magnesium is known to exert several beneficial effects, including antiglycemic and antilipidemic properties. The aim of this study was to evaluate the effects of magnesium supplementation on gene expression related to insulin and lipid metabolism in women with gestational diabetes (GDM) who were not on oral hypoglycemic agents. This randomized double-blind, placebo-controlled trial was conducted among 40 patients diagnosed with GDM, aged 18-40 years. Participants were randomly allocated into two groups to take either 250 mg/day of magnesium supplements in the form of magnesium oxide (n = 20) or placebo (n = 20) for 6 weeks...
August 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/28869208/factors-associated-with-magnesemia-in-patients-with-chronic-kidney-disease
#11
Chien-Te Lee, Yueh-Ting Lee, Wei-Hung Kuo, Terry Ting-Yu Chiou, Long-Chih Li, Hwee-Yeong Ng, Chia-An Chou, Wen-Chin Lee
Previous studies have indicated diabetes was associated with lower serum magnesium (Mg) level. Patients with renal impairment usually have higher Mg concentration due to reduced renal excretion. Whether Mg level in diabetics with chronic kidney disease (CKD) is altered remains undermined. In this study, we analyzed serum Mg concentration in patients with CKD and also compared diabetics with non-diabetics. Factors associated with Mg levels were explored. A total of 939 patients were included and 717 were with CKD...
May 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/28869207/effect-of-magnesium-on-the-osteogenesis-of-normal-human-osteoblasts
#12
Wei-Chen Lu, Ekaterini Pringa, Laisheng Chou
Biomaterials containing magnesium are used for implants and bone regeneration. However, mechanisms underlying the biologic effects of magnesium are still largely unknown and have not been examined on normal human osteoblasts. This study was designed to test the effect of supplemented Mg2+ concentrations between 0.5 mM and 16 mM on the osteogenic behaviors of normal human primary osteoblasts. Human primary osteoblasts were cultured in the groups with various concentrations of supplemented magnesium for various time intervals...
May 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/28869206/serum-magnesium-and-calcium-levels-in-infertile-women-during-a-cycle-of-reproductive-assistance
#13
Elena Grossi, Sara Castiglioni, Claudia Moscheni, Patrizio Antonazzo, Irene Cetin, Valeria Maria Savasi
Magnesium (Mg) and calcium (Ca) are essential cations for women's preconception health. It is well known that, in blood, the concentration of ionized form of these two cations is temporally altered during menstrual cycle, suggesting a correlation between sex steroid hormones and serum calcium and magnesium levels. Evidence from literature suggests that in assisted reproductive technology increasing estrogens during ovarian hyperstimulation may also modulate serum magnesium and calcium levels. Therefore, we first examined total serum magnesium and calcium levels during follicular phase in a large population of infertile patients who underwent intrauterine insemination (IUI)...
May 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/28816171/effect-of-magnesium-supplementation-on-muscular-damage-markers-in-basketball-players-during-a-full-season
#14
Alfredo Córdova Martínez, Diego Fernández-Lázaro, Juan Mielgo-Ayuso, Jesús Seco Calvo, Alberto Caballero García
Although it has been widely accepted that Mg has a positive effect on muscle function, studies on the efficacy of Mg supplementation in young athletes have generated contrasting results. The aim of this work was to examine the effect of Mg supplementation on muscular damage markers and the association between serum Mg levels with these muscular markers. Twelve elite male basketball players (PB) from a team of Spanish Professional Basketball League and a control group (CG) comprising twelve university students who practiced regularly recreational basketball and competed in minor university leagues participated in this study...
May 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/28417897/oral-magnesium-supplementation-reduces-the-incidence-of-gastrointestinal-complications-following-cardiac-surgery-a-randomized-clinical-trial
#15
RANDOMIZED CONTROLLED TRIAL
Seyed Tayeb Moradian, Mohammad Saeid Ghiasi, Alireza Mohamadpour, Yadollah Siavash
Gastrointestinal complications are common after coronary artery bypass graft surgery. These complications are ranged from nausea and vomiting to mesenteric ischemia and liver failure. It seems that nausea, vomiting, and constipation are related to magnesium deficiency. This study was designed to examine the effect of oral magnesium supplementation on the incidence of gastrointestinal complications in patients undergoing cardiac surgery. In a single blinded randomized clinical trial, 102 patients who were undergoing coronary artery bypass graft surgery were randomly allocated into two groups, 52 patients in the intervention and 50 patients in control group...
February 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/28417896/production-and-precipitation-hardening-of-mg-ca-zn-co-alloy-for-tissue-engineering
#16
Ilven Mutlu
In this study, Mg-Ca-Zn-Co alloy specimens for biomedical applications were produced by the powder metallurgy method. The Mg-Ca-Zn-Co alloy could be used as a scaffold material in tissue engineering applications. Electrochemical corrosion behavior of the specimens was investigated in simulated body fluid environment. Electrochemical corrosion resistance of the specimens was increased with increasing Zn and Ca contents of the alloy up to an optimum composition and then decreased. Optimum values for Ca and Zn additions were about 0...
February 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/28392499/burning-magnesium-a-sparkle-in-acute-inflammation-gleams-from-experimental-models
#17
REVIEW
Sara Castiglioni, Alessandra Cazzaniga, Laura Locatelli, Jeanette Am Maier
Magnesium contributes to the regulation of inflammatory responses. Here, we focus on the role of magnesium in acute inflammation. Although present knowledge is incomplete to delineate an accurate scenario and a schedule of the events occurring under magnesium deficiency, it emerges that low magnesium status favors the induction of acute inflammation by sensitizing sentinel cells to the noxious agent, and then by participating to the orchestration of the vascular and cellular events that characterize the process...
February 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/28392498/magnesium-in-the-gynecological-practice-a-literature-review
#18
REVIEW
Fabio Parazzini, Mirella Di Martino, Paolo Pellegrino
A growing amount of evidence suggests that magnesium deficiency may play an important role in several clinical conditions concerning women health such as premenstrual syndrome, dysmenorrhea, and postmenopausal symptoms. A number of studies highlighted a positive correlation between magnesium administration and relief or prevention of these symptoms, thus suggesting that magnesium supplementation may represent a viable treatment for these conditions. Despite this amount of evidence describing the efficacy of magnesium, few and un-systematize data are available about the pharmacological mechanism of this ion for these conditions...
February 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/27624533/changes-in-circulating-levels-of-fibroblast-growth-factor-23-induced-by-short-term-dietary-magnesium-deficiency-in-rats
#19
Hiroshi Matsuzaki, Shinichi Katsumata, Yoshiaki Maeda, Yasutaka Kajita
Fibroblast growth factor 23 (FGF23) is a potent regulator of phosphorus (P) and vitamin D metabolism. Long-term dietary magnesium (Mg) deficiency increases circulating levels of FGF23, whereas the effects of short-term dietary Mg deficiency are unclear. Thus, the present study investigated whether short-term dietary Mg deficiency affects circulating levels of FGF23. We also assessed changes in renal mRNA expression of vitamin D metabolizing enzymes and type II sodium-phosphate (Na/Pi) cotransporters, since these are regulated by FGF23...
June 1, 2016: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/27624532/hypomagnesemia-associated-with-hypocalcemia-after-total-thyroidectomy-an-observational-study
#20
Renata Regina da Graça Lorencetti Mahmoud, Vergilius José Furtado de Araujo Neto, Wellington Alves, Chin Shien Lin, Ana Kober Nogueira Leite, Leandro Luongo Matos, Vergilius José Furtado de Araujo Filho, Claudio Roberto Cernea
INTRODUCTION: Serum magnesium is frequently low in patients with hypocalcemia after total thyroidectomy. The aim of the present study was to analyze the variations in serum magnesium and calcium concentrations after total thyroidectomy, and the relationship between both ions. MATERIALS AND METHODS: We conducted an observational study of 142 patients who had undergone total thyroidectomy, measuring serum calcium and magnesium levels preoperatively and on the day following surgery...
June 1, 2016: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
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