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Journal of Pharmacy Practice

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https://www.readbyqxmd.com/read/29764337/response-to-letter-to-the-editor-implementation-of-a-cardiac-transitions-of-care-pilot-program-a-prospective-study-of-inpatient-and-outpatient-clinical-pharmacy-services-for-patients-with-heart-failure-exacerbation-or-acute-myocardial-infarction
#1
https://www.readbyqxmd.com/read/29621914/transitions-of-care-pilot-programs-we-have-your-missing-positive-results
#2
Danielle Mae N Thanh, Chad Bradford, Eric J Ip, Michael Kwong, Lucas Chang, Liu Sui, Gabriela Young, Mitchell J Barnett
No abstract text is available yet for this article.
June 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29279030/case-report-of-ipilimumab-induced-diffuse-nonnecrotizing-granulomatous-lymphadenitis-and-granulomatous-vasculitis
#3
Kari Arellano, James C Mosley, Donald C Moore
Ipilimumab is indicated for the treatment of melanoma in both the metastatic and adjuvant setting. Ipilimumab inhibits cytotoxic T-lymphocyte antigen 4, leading to the augmentation of T-cell activity and an antitumor immune system response. The side effect profile of ipilimumab consists of autoimmune-like events such as dermatitis, colitis, and thyroiditis. These immune-related adverse events can be serious, often resulting in the need for systemic immunosuppression with corticosteroids. We present a case of diffuse, nonnecrotizing granulomatous lymphadenitis and granulomatous vasculitis in a heavily pretreated patient with metastatic melanoma...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28974137/re-praluent-alirocumab-induced-renal-injury
#4
Robert S Rosenson, Dominique Larrey, David D Waters, Anders G Olsson
No abstract text is available yet for this article.
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28610453/proposed-criteria-for-the-use-of-low-dose-vitamin-k-supplementation-in-patients-using-vitamin-k-antagonists-a-literature-review-of-a-clinical-controversy
#5
Christy E Evans, Katerine E Getchell, Delaney R Ivy
BACKGROUND: Vitamin K antagonists (VKAs) have been used for decades to prevent thromboembolic events, but can be burdensome to patients based on numerous factors impacting anticoagulation control. Low-dose vitamin K supplementation has been theorized to improve anticoagulation control in patients on VKAs that may be vitamin K deficient. The objective of this literature review is to propose criteria for implementing low-dose vitamin K supplementation in patients on VKAs. LITERATURE REVIEW: The CHEST 2012 antithrombotic guidelines recommended against routine use of vitamin K supplementation in patients on VKAs...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28569127/a-retrospective-study-of-patient-factors-that-indicate-provider-nonadherence-to-an-institutional-clostridium-difficile-treatment-guideline
#6
Jeremy T Siehnel, Jill E Lavigne, Elizabeth A Rightmier, Will T Bossard, Na Li, Judianne C Slish
BACKGROUND: Clostridium difficile infection (CDI) is treated most often with metronidazole or vancomycin. Both have been effective in treatment of mild to moderate infection. In more severe cases, vancomycin may be more effective. OBJECTIVES: The primary objectives were to quantify the severity of CDI and to describe overall adherence to the institutional CDI guideline. Secondary objectives were to assess factors associated with adherence to the guidelines. METHODS: Retrospective analysis of the electronic medical record was used to evaluate adherence to institutional guidelines...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28558493/a-review-of-the-efficacy-and-safety-of-genvoya%C3%A2-elvitegravir-cobicistat-emtricitabine-and-tenofovir-alafenamide-in-the-management-of-hiv-1-infection
#7
Sara A Angione, Sibyl M Cherian, Ayşe Elif Özdener
INTRODUCTION: This review evaluates the efficacy and safety of Genvoya® (elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide [EVG/c/TAF/FTC]), a single-tablet regimen used for the management of HIV-1 infection. Phase II and III randomized clinical trials evaluate the efficacy and safety of EVG/c/TAF/FTC and tenofovir disoproxil fumerate (TDF)-containing arms; renal impairment, bone mineral density, metabolic effects, and other adverse events are topics explored within this review...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28506106/management-of-direct-acting-oral-anticoagulants-surrounding-dental-procedures-with-low-to-moderate-risk-of-bleeding
#8
Kathleen A Lusk, Jenna L Snoga, Rebekah M Benitez, G Blair Sarbacker
The purpose of this article is to review the available evidence regarding how to safely manage direct-acting oral anticoagulant (DOAC) therapy in patients requiring dental procedures with low-to-moderate risk of bleeding. A literature search was performed using MEDLINE and PubMed. Each author performed an independent search to ensure all pertinent articles were identified. The reference sections of each article were also reviewed. Pertinent articles were evaluated by each author for inclusion. Articles were eligible for inclusion if the participants were taking DOAC therapy surrounding a dental procedure known to have low-to-moderate risk of bleeding...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28490220/solithromycin-cem-101-a-new-fluoroketolide-antibiotic-and-its-role-in-the-treatment-of-gonorrhea
#9
Alexandra M Mancuso, Mona A Gandhi, Judianne Slish
Solithromycin is a macrolide antibiotic that has undergone review for the treatment of community-acquired bacterial pneumonia. Solithromycin is also being investigated and has shown promise for the treatment of gonorrhea. With increasing antibiotic resistance, the development of novel antibiotics to combat infections is essential. The unique ribosome-binding stability of solithromycin and mild side effect profile make this a promising new antibiotic. This article will provide an overview on the mechanism of action, clinical efficacy, and safety of this drug for the treatment of gonorrhea...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28468524/accountable-care-in-transitions-action-a-team-based-approach-to-reducing-hospital-utilization-in-a-patient-centered-medical-home
#10
Emily M Hawes, Jennifer N Smith, Nicole R Pinelli, Rayhaan Adams, Gretchen Tong, Sam Weir, Mark Gwynne
BACKGROUND: There is limited data describing the role of the patient-centered medical home (PCMH) in successful transitions programs and more information is needed to determine the transition points where pharmacist involvement is most impactful. METHODS: A family medicine center developed a multidisciplinary outpatient-based transitions program focused on reducing emergency department (ED) and hospital use in medically complex patients. Key team members were a medical provider, clinical pharmacist practitioner (CPP), and care manager...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28464760/transition-from-subcutaneous-or-inhaled-treprostinil-to-oral-treprostinil-at-home-in-patients-with-pulmonary-arterial-hypertension-a-retrospective-case-series
#11
Kimberly A Ackerbauer, Rajive Tandon
Pulmonary arterial hypertension (PAH) is a progressive condition that can lead to right ventricular failure and death. Treprostinil is a prostacyclin analogue that has proven clinical efficacy in patients with PAH. Difficulties in the administration of inhaled and parenteral prostacyclins led to the development of extended-release treprostinil diolamine for oral use. Limited data exist on the transition to oral treprostinil. The purpose of this case series is to describe the transition from subcutaneous or inhaled treprostinil to oral treprostinil in the outpatient setting...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28460560/evaluation-of-a-hybrid-training-module-for-community-pharmacy-staff-providing-hypertension-medication-therapy-management
#12
Wendy I Brown, Dan Cernusca, Leneika Roehrich
PURPOSE: The purpose of this research study was to evaluate the impact of web-based training on the knowledge and perceived practice of community pharmacy staff engaged in a hypertension medication therapy management program. Following the recommendations from adult learning end experiential learning theoretical frameworks, the proposed training engaged learners in a series of short online educational videos with preknowledge and postknowledge assessment and patient interactions in a clinical setting to reenforce newly learned skills...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28441899/clinical-and-financial-outcomes-evaluation-of-multimodal-pharmacist-warfarin-management-of-a-statewide-urban-and-rural-population
#13
James C Lee, Kathleen E Horner, Michelle L Krummel, Deanna L McDanel
PURPOSE: To evaluate the efficacy, safety, and indirect financial outcomes of pharmacist face-to-face warfarin management with telephone-based distance management utilizing local laboratories or patient self-testing (PST). METHODS: A retrospective analysis of a clinic population of 336 patients on established warfarin therapy distributed statewide in rural and urban settings over a 6-month period was conducted. Participants were stratified into face-to-face management, telephone-based management utilizing local laboratory testing, and telephone-based management utilizing PST...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28441898/novel-route-of-sirolimus-administration-in-a-neonate
#14
Ashley B Clark, Indira Chandrasekar, Jennee Nickleson
A term newborn presented with widespread cutaneous erythematous to bluish lesions since birth. He had extensive lesions in the gastrointestinal tract, brain, retina, heart, and bones. He also developed an intestinal perforation due to erosion of an intestinal lesion. Due to his critical status and clinical presentation, he was initially diagnosed with multifocal lymphangioendotheliomatosis with thrombocytopenia (MLT), and sirolimus treatment was initiated. Sirolimus was given by buccal route in this nonfeeding patient...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28438075/concomitant-presence-of-egfr-and-alk-fusion-gene-mutation-in-adenocarcinoma-of-lung-a-case-report-and-review-of-the-literature
#15
Nishitha Thumallapally, Hana Yu, Mohammad Farhan, Uroosa Ibrahim, Maricel Odiami
Empirical evidence has long suggested that oncogenic driver mutations in non-small-cell lung cancer are mutually independent. However, recent studies reported in pertinent literature reveal that concomitant epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangement can occur in a subset of patients with NSCLC. In order to shed further light on this issue, we report a case of adenocarcinoma of lung harboring both EGFR mutation in exon 21 (L861Q) and ALK rearrangement...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28429628/relationship-of-steroid-dosing-and-duration-of-mechanical-ventilation-in-adult-patients-with-acute-exacerbations-of-chronic-obstructive-pulmonary-disease
#16
Jennifer McCann, Katherine Teare, Emily Cochard, Brent Toney
BACKGROUND: The optimal steroid dose for patients who require mechanical ventilation (MV) for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is unknown. OBJECTIVE: The primary objective of the study is to describe the relationship between steroid doses prescribed and duration of MV. METHODS: This was a retrospective study of patients admitted between October 2013 and September 2014 who were prescribed steroids and received MV for ≥48 hours for AECOPD...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28403679/levofloxacin-induced-acute-immune-mediated-thrombocytopenia-of-rapid-onset
#17
Andrew W Shih, Andy S Lam, Theodore E Warkentin
Drug-induced immune thrombocytopenia (D-ITP) typically occurs after the patient has been receiving the implicated drug for at least 1 week, due to newly forming drug-dependent antibodies ("typical-onset" D-ITP). A "rapid-onset" form of D-ITP can occur when previous sensitization has occurred, where antibodies have thus already been formed, and a precipitous platelet count fall occurs upon reexposure. Typical-onset D-ITP has been reported after levofloxacin, but the rapid-onset form with a well-documented previous exposure has not been described...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28393657/pharmacist-and-technician-perceptions-of-tech-check-tech-in-community-pharmacy-practice-settings
#18
Timothy P Frost, Alex J Adams
OBJECTIVE: Tech-check-tech (TCT) is a practice model in which pharmacy technicians with advanced training can perform final verification of prescriptions that have been previously reviewed for appropriateness by a pharmacist. Few states have adopted TCT in part because of the common view that this model is controversial among members of the profession. This article aims to summarize the existing research on pharmacist and technician perceptions of community pharmacy-based TCT. DATA SOURCES: A literature review was conducted using MEDLINE (January 1990 to August 2016) and Google Scholar (January 1990 to August 2016) using the terms "tech* and check," "tech-check-tech," "checking technician," and "accuracy checking tech*...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28378619/analysis-of-pgy-1-pharmacy-resident-candidate-letters-of-recommendation-at-an-academically-affiliated-residency-program
#19
Milena M McLaughlin, Dalila Masic, Jacob P Gettig
BACKGROUND: Letters of recommendation (LORs) are a critical component for differentiating among similarly qualified pharmacy residency candidates. These letters contain information that is difficult to ascertain from curricula vitae and pharmacy school transcripts. LOR writers may use any words or phrases appropriate for each candidate as there is no set framework for LORs. OBJECTIVE: The objective of this study was to characterize descriptive themes in postgraduate year 1 (PGY-1) pharmacy residency candidates' LORs and to examine which themes of PGY-1 pharmacy residency candidates' LORs are predictive of an interview invitation at an academically affiliated residency program...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28357892/suspected-synthetic-cannabinomimetic-intoxication-case-series-and-review
#20
Regan A Baum, Abby Bailey, Ryan Chan, Karen Blumenschein
PURPOSE: The purpose of this work was to retrospectively review patient cases presenting to the University of Kentucky Chandler Medical Center (UKCMC) emergency department (ED) with symptoms of suspected synthetic cannabinomimetic (SC) intoxication. These drugs, currently undetected by standard urine drug screen tests, comprise a structurally diverse group of compounds designed to mimic the psychoactive effects of Δ9 -tetrahydrocannabinol (Δ9 -THC), the primary psychoactive cannabinoid in marijuana...
April 2018: Journal of Pharmacy Practice
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