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Journal of Pharmacy Practice

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https://www.readbyqxmd.com/read/29439593/bleeding-risks-in-patients-on-percutaneous-ventricular-assist-devices-receiving-two-different-dextrose-concentrations-of-heparinized-purge-solution-a-case-series
#1
Jenna N Dietrich, Hasan Kazmi
BACKGROUND: The Impella manufacturer has changed its recommendation for the diluent of the heparinized purge solution from 20% dextrose (D20) to 5% dextrose (D5). This reduced viscosity may result in increased purge solution infusion rates and unfractionated heparin (UFH) exposure. Increased UFH exposure could potentially cause increased bleeding events and may necessitate reduction in UFH concentration in the purge solution. Our objective was to evaluate anticoagulation for patients on Impella pumps receiving heparinized purge solution with D20 or D5 diluents...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29390946/successful-phenobarbital-desensitization-after-dress-reaction-in-the-management-of-refractory-status-epilepticus
#2
Robert H Witcher, Michelle M Ramirez
PURPOSE: Drug reaction with eosinophilia and systemic symptoms (DRESS) is associated with antiepileptic drug use and is a rare but life-threatening side effect. We present a case of phenobarbital-induced DRESS in a patient who subsequently required phenobarbital and was successfully desensitized. SUMMARY: A 5-year-old male presented with medically refractory status epilepticus (SE). He had been trialed on several antiepileptic medications without achieving burst suppression...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29366379/pharmacy-student-monitoring-of-direct-oral-anticoagulants
#3
Jennifer J Kim, Hailey L Hill, James B Groce, James M Granfortuna, Tanya K Makhlouf
BACKGROUND: Best practice recommendations are lacking. Thus far, literature has described pharmacist-led DOAC monitoring. OBJECTIVE: The purpose of this study is to describe a DOAC monitoring program involving pharmacy students. METHODS: This was an observational analysis of a quality improvement initiative. A clinical pharmacist preceptor identified clinic patients taking DOACs by running a report using the electronic medical record. Pharmacy students conducted chart reviews, called pharmacies for 6-month refill histories, and interviewed and educated patients...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29357729/evaluation-of-time-spent-by-pharmacists-and-nurses-based-on-the-location-of-pharmacist-involvement-in-medication-history-collection
#4
Anmol Chhabra, Andrea Quinn, Amanda Ries
BACKGROUND: Accurate history collection is integral to medication reconciliation. Studies support pharmacy involvement in the process, but assessment of global time spent is limited. The authors hypothesized the location of a medication-focused interview would impact time spent. METHODS: The objective was to compare time spent by pharmacists and nurses based on the location of a medication-focused interview. Time spent by the interviewing pharmacist, admitting nurse, and centralized pharmacist verifying admission orders was collected...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29355072/topiramate-induced-chest-pain-a-case-report
#5
Jared L Ostroff, Jessica N LeClair Barnet, Marissa L Ostroff, Corey S Laskey
BACKGROUND: Topiramate, an anticonvulsant used for prophylaxis of migraines and epilepsy, is commonly associated with adverse effects of cognitive dulling and fatigue. Chest pain is a potential adverse effect that to our knowledge has not been reported with the use of topiramate. CASE PRESENTATION: We present the case of a 38-year-old female with a seizure disorder who experienced chest pain after the first dose of topiramate. On day 1, she presented to the emergency department, was admitted, and over the course of 3 days had a chest X-ray, electrocardiogram (ECG), and echocardiogram, and her vitals, basic metabolic panel, complete blood counts, troponin, and d-dimer levels were monitored...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29334864/pain-assessment-documentation-after-opioid-administration-at-a-community-teaching-hospital
#6
Megan E Phillips, Rod A Gilmore, Melody C Sheffield, Stephanie V Phan
PURPOSE: To compare pain assessment documentation postopioid administration in hospitalized patients before and after implementing nurse education. METHODS: Patients 18 years and older were randomly selected for inclusion if they received 1 opioid dose while admitted to the hospital. Through retrospective chart review, opioid data, including date and time, were collected for each opioid administered. Pain score data, including time and date of documentation, were recorded for analysis...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29334810/monitoring-of-metabolic-adverse-effects-associated-with-atypical-antipsychotics-use-in-an-outpatient-psychiatric-clinic
#7
Luis Pereira, Aliaksandr Budovich, Maria Claudio-Saez
BACKGROUND: Atypical antipsychotics are associated with metabolic complications that contribute to a higher risk of cardiovascular disease. Current evidence reveal suboptimal adherence to the complex and variable official recommendations on metabolic monitoring in the corresponding patient population. A study evaluating metabolic monitoring at guideline-recommended intervals may help identify areas for intervention. OBJECTIVE: Describe the frequency of monitoring metabolic adverse effects in patients receiving atypical antipsychotics in an outpatient psychiatric clinic with respect to the specific guideline-recommended intervals...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29325483/characterization-of-vaccination-policies-for-attendance-and-employment-at-day-summer-camps-in-new-york-state
#8
William A Prescott, Kelsey C Violanti, Nicholas M Fusco
INTRODUCTION: New York state requires day/summer camps to keep immunization records for all enrolled campers and strongly recommends requiring vaccination for all campers and staff. The objective of this study was to characterize immunization requirements/recommendations for children/adolescents enrolled in and staff employed at day/summer camps in New York state. METHODS: An electronic hyperlink to a 9-question survey instrument was distributed via e-mail to 178 day/summer camps located in New York state cities with a population size greater than 100 000 people...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29310494/effectiveness-of-vancomycin-or-beta-lactam-therapy-in-ampicillin-susceptible-enterococcus-spp-bloodstream-infections
#9
Jesse M Fletcher, Shawn J Kram, Christina B Sarubbi, Deverick J Anderson, Bridgette L Kram
BACKGROUND: De-escalation to a beta-lactam improves outcomes for patients with a methicillin-susceptible Staphylococcus aureus bloodstream infection (BSI). Whether a similar strategy is appropriate for enterococcal species is less clear. OBJECTIVE: To determine whether definitive antibiotic selection affects outcomes for patients with an ampicillin-susceptible enterococcal BSI. METHODS: This retrospective cohort study included patients over 18 years of age receiving definitive therapy with vancomycin or a beta-lactam for one or more blood cultures positive for Enterococcus spp...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29278992/comorbidity-polytherapy-and-drug-interactions-in-a-neurological-context-an-example-of-a-multidisciplinary-approach-to-promote-the-rational-use-of-drugs
#10
Giulia Busa, Alessandro Burlina, Vera Damuzzo, Marco Chiumente, Angelo C Palozzo
PURPOSE: A high number of adverse drug reactions (ADRs), mainly caused by drug-drug interactions (DDIs), occur in neurological wards and few data are available about incidence and prevalence of DDIs in this context. This study investigated-(1) the prevalence of drug-drug and drug-disease interactions in patients admitted to a neurological unit in Italy, (2) the risk factors for DDIs, and (3) the diseases and the drug classes mostly involved in drug-drug and drug-disease interactions. METHODS: For 2 months, we performed a retrospective, observational study in the neurological unit of St Bassiano Hospital, enrolling 79 patients who received a drug prescription at discharge...
February 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29278971/prevention-strategies-against-hiv-transmission-a-proactive-approach
#11
Antonio J Carrion, Jovan D Miles, Juan F Mosley, Lillian L Smith, April S Prather, Marcus M Gurley, Linh D Phan, Emily C Everton
Human immunodeficiency virus (HIV) has now transformed into a manageable chronic condition. Highly active antiretroviral therapy (HAART) has proven efficacious at controlling the disease progression. Based on compelling evidence, the Department of Health and Human Services (DHHS) and the Infectious Disease Society of America (IDSA) developed guidelines for the management of persons infected with HIV. However, there are approximately 50 000 new cases of HIV in the United States each year. In this article, we review proactive methods to reduce the transmission of HIV, which include reinforcing patient education, gel-coated condoms that destroy HIV, HIV vaccinations, and adequately utilizing pre-exposure prophylaxis (PrEP), and post-exposure prophylaxis (PEP)...
February 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29121839/simplifying-piperacillin-tazobactam-dosing-pharmacodynamics-of-utilizing-only-4-5-or-3-375-g-doses-for-patients-with-normal-and-impaired-renal-function
#12
Abrar K Thabit, Mordechai Grupper, David P Nicolau, Joseph L Kuti
OBJECTIVES: To evaluate the pharmacodynamic exposure of piperacillin/tazobactam across the renal function range using 4.5 or 3.375 g dosing regimens. METHODS: A 5000-patient Monte Carlo simulation was conducted to determine the probability of achieving 50% free time above the minimum inhibitory concentration ( fT > MIC) for piperacillin. Proposed regimens, using solely 4.5 or 3.375 g strengths, were compared with regimens listed in piperacillin/tazobactam prescribing information over creatinine clearance (CrCl) ranges of 120 mL/min to hemodialysis...
December 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29121838/possible-trimethoprim-sulfamethoxazole-induced-hemolytic-anemia-a-case-report
#13
Montgomery F Williams, Emily P Doss, Maggie Montgomery
OBJECTIVE: To report a case of hemolytic anemia in a patient who received trimethoprim/sulfamethoxazole (TMP-SMX) for a urinary tract infection (UTI). SUMMARY: A 47-year-old woman recently diagnosed with uncomplicated UTI received 3 doses of TMP-SMX. She developed yellowing of the skin and eyes, lethargy, mild abdominal pain, and dry mucous membranes. Laboratory testing demonstrated significant anemia with red blood cells (RBCs) of 1.99, hemoglobin (Hgb) of 6.3 g/dL, and hematocrit (Hct) of 18...
December 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27402634/prescription-opioid-misuse-among-rural-community-pharmacy-patients-pilot-study-for-screening-and-implications-for-future-practice-and-research
#14
Gerald T Cochran, Rafael J Engel, Valerie J Hruschak, Ralph E Tarter
BACKGROUND: Opioid misuse imposes a disproportionately heavy burden on individuals living in rural areas. Community pharmacy has the potential to expand and coordinate with health professionals to identify and intervene with those who misuse opioids. OBJECTIVE: Rural and urban community pharmacy patients were recruited in this pilot project to describe and compare patterns of opioid misuse. METHODS: We administered a health screening survey in 4 community pharmacies among patients filling opioid medications...
October 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27166390/aflibercept-a-review-of-its-use-in-the-management-of-diabetic-eye-complications
#15
Oluwaranti Akiyode, Jateh Major, Abiola Ojo
Aflibercept is the most recently approved vascular endothelial growth factor (anti-VEGF) inhibitor for the management of diabetic macular edema and diabetic retinopathy. The purpose of this article is to review the efficacy and safety of aflibercept in the management of diabetic eye complications and to describe its place in therapy. Anti-VEGF agents have been noted in clinical trials to be superior to laser photocoagulation, the standard therapy ( P < .0001, P ≤ .0085, respectively). Aflibercept has been comparatively studied with other anti-VEGF agents, namely, bevacizumab and ranibizumab, and noted to be equally efficacious and safe in patients with mild visual acuity loss ( P > ...
October 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27139887/the-future-of-intensive-care-unit-sedation-a-report-of-continuous-infusion-ketamine-as-an-alternative-sedative-agent
#16
Scott T Benken, Alexandra Goncharenko
This report describes a patient case utilizing a nontraditional sedative, continuous infusion ketamine, as an alternative agent for intensive care unit (ICU) sedation. A 27-year-old female presented for neurosurgical management of a coup contrecoup injury, left temporal fracture, epidural hemorrhage (EDH), and temporal contusion leading to sustained mechanical ventilation. The patient experienced profound agitation during mechanical ventilation and developed adverse effects with all traditional sedatives: benzodiazepines, dexmedetomidine, opioids, and propofol...
October 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28726566/college-of-psychiatric-and-neurologic-pharmacists-abstracts
#17
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28726565/nyschp-annual-assembly-2016-poster-abstracts
#18
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28726564/nyschp-residency-research-practice-forum-2017-platform-presentation-abstracts
#19
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27599749/a-closer-look-at-the-2015-beers-criteria
#20
Rebecca L Salbu, Judith Feuer
The Beers Criteria identifies potentially inappropriate medications for patients who are 65 years of age and older. Initially published in 1991, the criteria have been updated multiple times, most recently in 2015. The Beers Criteria is a tool designed to alert health-care providers to the potential harms of specific medications so they may better tailor therapeutic regimens for their elderly patients. The expert panel of the 2015 update made changes to a number of previous recommendations and provided 2 new tables on select drug interactions and select medications requiring renal dose adjustments...
August 2017: Journal of Pharmacy Practice
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