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Journal of Pharmacy Practice

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https://www.readbyqxmd.com/read/30541367/first-line-therapies-for-vte-treatment-and-secondary-prophylaxis-in-patients-with-cancer-a-new-direction
#1
Samantha M Vogel, Leticia V Smith, Evan J Peterson
OBJECTIVE: To review evidence behind anticoagulants in cancer-associated venous thromboembolism (VTE) with a focus on low-molecular-weight heparins (LMWH) and the role of direct oral anticoagulants (DOACs). DATA SOURCES: PubMed was searched using terms "venous thromboembolism," "cancer," and "anticoagulation." This search was restricted to clinical trials, meta-analyses, and subgroup analyses. Additional references were identified from reviewing literature citations...
December 12, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30522384/standardizing-the-use-of-albumin-in-large-volume-paracentesis
#2
Shelby S Anderson, Julian B McCreary, Kristin S Alvarez, L Steven Brown, Deepak Agrawal
BACKGROUND: Albumin after large volume paracentesis (LVP) reduces paracentesis-induced circulatory dysfunction (PICD). The most efficacious dose of albumin for LVP is unclear. OBJECTIVE: To evaluate the impact of implementing a standardized LVP order set on albumin utilization and patient outcomes. METHODS: This is a retrospective review of patients with ascites due to cirrhosis who received a therapeutic paracentesis at a large, academic institution...
December 6, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30522377/acute-care-pharmacy-practice-a-perspective-for-pharmacy-students-residents-and-other-health-care-providers
#3
Rebecca L Dunn, Jonathan C Cho, Brittany L Parmentier
PURPOSE: To describe the acute care setting with a specific focus on acute care pharmacy practices. SUMMARY: Acute care is the sector of health care where time-sensitive episodes of illness are managed. Acute care pharmacy practice includes both hospital and clinical pharmacists serving, in a variety of domains, as medication experts and authority on patient-centered medication therapy. Pharmacists serving in this area can have a beneficial impact on patient care and the health-care system...
December 6, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30518297/early-experiences-with-pegylated-carboxyhemoglobin-bovine-in-anemic-jehovah-s-witnesses-a-case-series-and-review-of-the-literature
#4
Sean McConachie, Krista Wahby, Zinah Almadrahi, Sheila Wilhelm
Jehovah's Witnesses (JW) represent a complex patient population due to their refusal to accept blood transfusions on religious grounds. Pharmacologic management of anemic JW patients is limited to stimulation of hematopoiesis by iron and erythropoietin supplementation and reduction of blood loss by prothrombin complex concentrates (PCCs). Hemoglobin-based oxygen carriers (HBOCs) represent the only pharmacologic modality for JW patients capable of acutely increasing a patient's oxygen carrying capacity in the setting of organ failure, yet clinical safety and efficacy data are lacking in this population...
December 5, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30518289/differences-in-career-satisfaction-work-life-balance-and-stress-by-gender-in-a-national-survey-of-pharmacy-faculty
#5
Eric J Ip, Tristan A Lindfelt, Annie L Tran, Amanda P Do, Mitchell J Barnett
INTRODUCTION: The percentage of women pharmacy students and pharmacy faculty has greatly increased over the last 40 years. However, it is not known whether gender differences exist in terms of career satisfaction, work-life balance, and stress in the pharmacy academia workplace. METHODS: Results from a national web-based survey administered to American Association of Colleges of Pharmacy (AACP) members were utilized. Bivariate analyses were conducted to compare differences among faculty according to gender (men vs women)...
December 5, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30497313/development-implementation-and-evaluation-of-introductory-pharmacy-practice-experiences-at-an-academic-medical-center
#6
Ashley Thompson-Quan, Judie T Tran, Valerie Clinard
PURPOSE: Introductory pharmacy practice experiences (IPPEs) for pharmacy students are required by the Accreditation Council for Pharmacy Education, but guidance for rotational structure is limited. OBJECTIVE: To describe the design, implementation, and evaluation of IPPE rotations at a large, multisite, academic medical center. CONCLUSION: A large IPPE program was successfully implemented and sustained. Rapid cycle changes were made based on post rotational surveys completed by both preceptors and IPPE students to assess and modify the rotations until the average experience was rated at least a 4 on a 5 point scale, illustrating a mutually beneficial collaboration between the Medical Center and the School of Pharmacy...
November 29, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30486709/reducing-medication-administration-frequency-in-veteran-community-living-centers
#7
Jesus Melendez, Rita Bodine, Karen Park
BACKGROUND: A quality improvement initiative of the Veterans Health Administration (VHA) aims to reduce frequency of medication administration to Veterans per day. Medication administration practices in our community living center (CLC) units are similar to an acute care medical unit versus a home environment. The objective of this project was to reduce medication administration frequency in order to minimize the number of interruptions to both Veterans and nurses. METHODS: A retrospective chart review was conducted for Veterans residing in a pilot CLC from January through March 2018...
November 28, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30453817/influenza-and-intentions-to-vaccinate-in-an-underserved-hispanic-population-the-role-of-theoretically-derived-constructs
#8
Margie E Padilla, Gabriel Frietze, Jessica M Shenberger-Trujillo, Melissa Carrillo, Amanda M Loya
BACKGROUND: Past research has focused on understanding influenza vaccine acceptance in non-Hispanic white populations; however, research on the social causes of influenza vaccine acceptance rates in Hispanic populations is slowly developing. OBJECTIVE: The purpose of this study was to assess theoretically driven predictors (i.e. attitudes, perceptions, behaviors, etc.) on influenza and the intention to vaccinate. METHODS: A survey was administered to assess predictors of intentions to receive the influenza vaccine...
November 19, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30428760/impact-of-physician-pharmacist-covisits-at-a-primary-care-clinic-in-patients-with-uncontrolled-diabetes
#9
Jasmine Peterson, April Hinds, Aida Garza, Jamie Barner, Lucas Hill, Michelle Nguyen, Phillip Lai, Tyler Gums
PURPOSE: A popular method for enhancing medication management within a patient-centered medical home (PCMH) is the physician-pharmacist collaborative management (PPCM) model. To improve efficiency of health-care delivery within 4 federally qualified health centers (FQHCs), the PPCM model was implemented through coordinated physician-pharmacist covisits. OBJECTIVE: To evaluate the impact of physician-pharmacist covisits on clinical outcomes among patients with uncontrolled diabetes...
November 14, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30428759/pharmacist-initiated-management-of-a-suspected-case-of-risperidone-induced-neuroleptic-malignant-syndrome-in-an-aged-care-resident-the-role-of-residential-medication-management-reviews-in-medication-safety
#10
Michael Morcos, Jonathan Corns, Jodie Belinda Hillen
A 70-year-old female aged-care resident was referred by her general practitioner for a residential medication management review after nurses reported difficulties with swallowing, episodes of hyperthermia, elevated blood pressure, and tachycardia. These symptoms were accompanied by increasing confusion and drowsiness. Risperidone had recently been prescribed to treat behavioral and psychological symptoms of dementia. This case study describes the pharmacist-initiated management of the symptoms through a national medication review program...
November 14, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30352534/emerging-topics-in-vaccine-therapeutics-for-adolescents-and-adults-an-update-for-immunizing-pharmacists
#11
Joseph P Fava, Brittany Stewart, Kathryn M Dudzinski, Michelle Baker, Lucio Volino
Vaccine therapeutics and the practice of immunization provision are ever-changing. As pharmacy-based immunization services continue to flourish in the United States, more and more patients are requesting both routine and travel vaccines in community pharmacies. However, vaccine recommendations from the Centers for Disease Control and Prevention/Advisory Committee on Immunization Practices (CDC/ACIP) can sometimes differ from product-specific US Food and Drug Administration (FDA)-indicated uses. In addition, changes in vaccine schedules, product availability, and disease outbreaks can present immunizing pharmacists with scenarios requiring a high level of clinical judgment...
October 23, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30343617/measuring-the-impact-of-medication-related-interventions-on-30-day-readmission-rates-in-a-skilled-nursing-facility
#12
Priya B Amin, Chad D Bradford, Albert L Rizos, Bijal M Shah
BACKGROUND: There is a lack of published literature that measures the impact of transitional care pharmacist (TCP) medication-related interventions within the skilled nursing facility (SNF) setting. OBJECTIVES: To evaluate the impact of TCP medication-related interventions on 30-day hospital readmissions among SNF patients compared to current standard of care. METHODS: This was a retrospective pilot study. All patients included in the study were discharged from an inpatient facility to a SNF...
October 21, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30343615/evaluation-of-clinical-pharmacist-services-in-a-transitions-of-care-program-provided-to-patients-at-highest-risk-for-readmission
#13
Jessica E Fennelly, Antoinette B Coe, Kellie A Kippes, Tami L Remington, Hae Mi Choe
BACKGROUND: An ambulatory transition of care program, including a pharmacist-provided comprehensive medication review (CMR), was implemented. OBJECTIVES: The objectives were to: (1) compare 30-day hospital readmission rates between those who received the pharmacist CMR versus eligible patients not scheduled, (2) describe identified problems and recommendations, and (3) quantify recommendation acceptance rates. METHODS: A retrospective cohort study was conducted between March and October 2016...
October 21, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30336720/lacosamide-pharmacokinetics-in-a-critically-ill-patient-during-continuous-renal-replacement-therapy
#14
Patrick M Wieruszewski, Arnaldo Lopez-Ruiz, Robert C Albright, Jennifer E Fugate, Erin Frazee Barreto
The objective of this study is to describe the pharmacokinetics of lacosamide in a critically ill adult during continuous venovenous hemofiltration (CVVH). A 78-year-old male developed sepsis and acute kidney injury following cardiac surgery. He was initially treated with intermittent hemodialysis but developed nonconvulsive status epilepticus at the end of the first session and was subsequently initiated on CVVH. In addition to lorazepam boluses, levetiracetam, and midazolam infusion, he was loaded with lacosamide 400 mg intravenously and started on 200 mg intravenously twice daily as maintenance therapy...
October 18, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30326771/continuous-infusion-ampicillin-for-the-outpatient-management-of-enterococcal-endocarditis-a-case-report-and-literature-review
#15
Paul O Lewis, Abigail Jones, Rachel J Amodei, Dima Youssef
Treatment of enterococcal endocarditis requires up to 6 weeks of intravenous (IV) antimicrobial therapy. When susceptible, an ampicillin-based regimen is preferred. Studies evaluating ampicillin stability utilizing high-pressure liquid chromatography have indicated enhanced stability (greater than 24 hours at room temperature), supporting outpatient administration. Thus, we report the successful treatment of a 30-year-old male with tricuspid valve enterococcal endocarditis in an outpatient setting using continuous infusion ampicillin via an ambulatory infusion pump...
October 16, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30296875/improved-medication-management-with-introduction-of-a-perioperative-and-prescribing-pharmacist-service
#16
Anny D Nguyen, Alice Lam, Iouri Banakh, Skip Lam, Tyron Crofts
BACKGROUND: The medication lists in pre-admission clinic (PAC) questionnaires completed by patients prior to surgery are often inaccurate, potentially leading to medication errors during hospitalization. Studies have shown pharmacists are more accurate when obtaining a medication history and transcribing prescription orders, thereby reducing errors. OBJECTIVE: To evaluate the impact of a PeRiopErative and Prescribing (PREP) pharmacist on postoperative medication management...
October 8, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30278817/characteristics-of-mail-order-pharmacy-users-results-from-the-medical-expenditures-panel-survey
#17
Junyi Ma, Li Wang
BACKGROUND: There is a paucity of research on the population characteristics of mail-order pharmacy users. OBJECTIVE: This study utilized a nationally representative sample to examine the characteristics of mail-order pharmacy users. METHODS: This study used data from the 2012 Medical Expenditure Panel Survey (MEPS). The outcome variable was defined as whether the participant had used a mail-order pharmacy during the study year. Logistic regression was conducted to determine the factors which influence mail-order pharmacy use...
October 2, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30278813/carfilzomib-induced-tumor-lysis-syndrome-and-other-adverse-events
#18
El Bitar Sandy, Chanudi Weerasinghe, Terenig Terjanian
In the area of multiple myeloma (MM) therapy, proteasome inhibitors (PI) have emerged with promising responses both in the first- and second-line setting. Carfilzomib (CFZ) is a second-generation, selective PI approved in 2012 for the treatment of relapsed/refractory multiple myeloma (RRMM) in patients who received 2 prior therapies or have evidence of disease progression within 60 days of completion of last therapy. Its safety profile reported adverse events (AEs) ranging from drug-related AEs (nausea and vomiting), hematologic AEs (neutropenia and thrombocytopenia), and nonhematologic AEs (electrolyte imbalances)...
October 2, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30270723/combined-insulin-and-glp-1-receptor-agonists-simplifying-treatment-or-adding-obstacles
#19
Tianrui Yang, B Tate Cutshall, Alexandra Tatara, Melanie Ruegger
The US Food and Drug Administration recently approved 2 combination products containing a basal insulin and a glucagon-like peptide 1 receptor agonist: insulin glargine/lixisenatide and insulin degludec/liraglutide. These agents were shown to be noninferior in lowering hemoglobin A1c compared to basal insulin and are indicated for patients inadequately controlled on basal insulin or glucagon-like peptide 1 receptor agonists alone. The clinical implications of these agents are unclear due to limitations in the clinical trials and limited recommendations in current guidelines...
October 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30253682/risk-of-nephrotoxicity-associated-with-nonrenally-adjusted-intravenous-polymyxin-b-compared-to-traditional-dosing
#20
Bejoy P Maniara, Lauren E Healy, Thien-Ly Doan
BACKGROUND: Polymyxin B's package insert recommends renal adjustment. Contemporary studies suggest it does not require renal adjustment. OBJECTIVE: To determine whether time to acute kidney injury (AKI) differs between renally adjusted and nonadjusted intravenous (IV) polymyxin B. METHODS: This retrospective chart review compared time to AKI after renally adjusted and nonadjusted IV polymyxin B administration. It included patients who were 18 years or older, received IV polymyxin B, and had creatinine clearance below 80 mL/min, and excluded ones who had AKI, received renal replacement therapy, or were pregnant...
September 25, 2018: Journal of Pharmacy Practice
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