journal
MENU ▼
Read by QxMD icon Read
search

Journal of Pharmacy Practice

journal
https://www.readbyqxmd.com/read/29279030/case-report-of-ipilimumab-induced-diffuse-nonnecrotizing-granulomatous-lymphadenitis-and-granulomatous-vasculitis
#1
Kari Arellano, James C Mosley, Donald C Moore
Ipilimumab is indicated for the treatment of melanoma in both the metastatic and adjuvant setting. Ipilimumab inhibits cytotoxic T-lymphocyte antigen 4, leading to the augmentation of T-cell activity and an antitumor immune system response. The side effect profile of ipilimumab consists of autoimmune-like events such as dermatitis, colitis, and thyroiditis. These immune-related adverse events can be serious, often resulting in the need for systemic immunosuppression with corticosteroids. We present a case of diffuse, nonnecrotizing granulomatous lymphadenitis and granulomatous vasculitis in a heavily pretreated patient with metastatic melanoma...
April 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29279045/ticagrelor-for-neuroendovascular-procedures-a-case-series
#2
Kyle Davis, Christopher Morrison
BACKGROUND: The development of thromboembolism is one of the most common complications of neuroendovascular procedures. Although several small studies have deemed clopidogrel safe and effective in the prevention of intracranial stent thrombosis, ticagrelor has yet to be assessed in this setting. OBJECTIVE: The objective of this study was to retrospectively evaluate the safety and efficacy of ticagrelor in patients undergoing neuroendovascular procedures. METHODS: A retrospective review of patients receiving ticagrelor following neuroendovascular aneurysm repair...
February 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29278993/adherence-to-gold-guidelines-in-the-inpatient-copd-population
#3
Melissa Lipari, Amber Lanae Smith, Pramodini B Kale-Pradhan, Sheila M Wilhelm
PURPOSE: The Global Initiative for Chronic Obstructive Lung Disease guidelines provide recommendations to manage chronic obstructive lung disease (COPD) exacerbations. This study assessed the management of inpatient COPD exacerbations at an urban teaching hospital. METHODS: A retrospective cohort analysis of adults admitted between December 2010 and August 2012 with a COPD exacerbation was conducted. Patient demographics, length of stay (LOS), Charlson comorbidity score, inpatient pulmonary medications, and 30-day readmission were collected...
February 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29278992/comorbidity-polytherapy-and-drug-interactions-in-a-neurological-context-an-example-of-a-multidisciplinary-approach-to-promote-the-rational-use-of-drugs
#4
Giulia Busa, Alessandro Burlina, Vera Damuzzo, Marco Chiumente, Angelo C Palozzo
PURPOSE: A high number of adverse drug reactions (ADRs), mainly caused by drug-drug interactions (DDIs), occur in neurological wards and few data are available about incidence and prevalence of DDIs in this context. This study investigated-(1) the prevalence of drug-drug and drug-disease interactions in patients admitted to a neurological unit in Italy, (2) the risk factors for DDIs, and (3) the diseases and the drug classes mostly involved in drug-drug and drug-disease interactions. METHODS: For 2 months, we performed a retrospective, observational study in the neurological unit of St Bassiano Hospital, enrolling 79 patients who received a drug prescription at discharge...
February 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29278991/managing-nonoperable-intracranial-bleeding-associated-with-apixaban-a-series-of-2-cases
#5
Andrew C Faust, Dang M Tran, Catherine Lo, Sophia Lai, Lyndsay Sheperd, Mary Liu, Tina Denetclaw
OBJECTIVE: To report 2 cases of nonoperable intracranial bleeding associated with apixaban managed by 3-factor prothrombin complex concentrate (PCC3). CASE SUMMARIES: Case 1 presented with a 1.3-cm left parieto-occipital hemorrhage and a thin subdural hematoma (SDH) on the left tentorium of the brain about 6 hours after his last dose of apixaban. Case 2 presented with a 4-mm left parafalcine SDH with time of most recent apixaban dose unknown. The patients received 24...
February 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29278990/clinical-outcomes-in-patients-with-gram-negative-infections-treated-with-optimized-dosing-cefepime-over-various-minimum-inhibitory-concentrations
#6
Jerry Altshuler, David J Guervil, Charles D Ericsson, Audrey Wanger, Samuel L Aitken, Luis Ostrosky-Zeichner
BACKGROUND: The Clinical and Laboratory Standards Institute (CLSI) revised cefepime interpretive criteria, introducing the susceptible dose-dependent category for Enterobacteriaceae with a minimum inhibitory concentration (MIC) of 4 to 8 μg/mL in 2014. Limited clinical data support these new categories. This study compares outcomes of patients treated with standard and high-dose cefepime across various MICs. METHODS: We retrospectively reviewed cases of pneumonia or bacteremia caused by gram-negative organisms treated with adequate doses of cefepime for ≥48 hours...
February 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29278987/impact-of-pharmacist-intervention-on-selection-and-timing-of-appropriate-antimicrobial-therapy-in-septic-shock
#7
Melanie E Laine, Jeremy D Flynn, Alexander H Flannery
BACKGROUND: Current guidelines for septic shock management recommend administration of appropriate, broad-spectrum antimicrobials within 1 hour of recognition. OBJECTIVE: To evaluate the interventions pharmacists make as part of a sepsis response team and to determine if these interventions increase the proportion of patients with appropriate empiric antimicrobial therapy. METHODS: A retrospective cohort study was undertaken reviewing adult patients in a large, academic medical center with confirmed septic shock who had an order for a "sepsis bundle," which includes notification of a pharmacist to assess adequacy of empiric therapy...
February 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29278982/the-use-of-kcentra-%C3%A2-in-the-reversal-of-coagulopathy-of-chronic-liver-disease
#8
Deepika Pereira, Eric Liotta, Ahmed A Mahmoud
We aim to describe our experience with the four-factor prothrombin complex concentrates (4F-PCC) Kcentra® at differing doses in patients with liver cirrhosis requiring emergent hemostasis in the setting of major or life-threatening bleeding. An automated query of patients who received Kcentra between January 2014 and March 2016 was performed. Patients who had clinically significant bleeding and received Kcentra for treatment of coagulopathy of chronic liver disease (CCLD) were included in the study. Baseline patient demographics, administration indication, pertinent laboratory values, and other reversal therapies were collected...
February 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29278980/clinic-level-population-health-intervention-by-pgy2-ambulatory-care-pharmacy-residents-to-optimize-medication-management-in-a-self-insured-employer-health-plan-population
#9
Joseph Vande Griend, Danielle R Fixen, Cy W Fixen, Jason Zupec, Joseph J Saseen
BACKGROUND: Postgraduate year 2 ambulatory care pharmacy residents (PGY2 residents) may be able to improve healthcare quality by providing clinical pharmacy services provided to self-insured employer health plan patients. The objectives of this study are to describe this care delivery in a family medicine clinic, and to identify patients most likely to benefit from the service. METHODS: From October 1, 2014 till June 30, 2015, comprehensive medication review was completed by PGY2 residents for patients insured by CU Anthem at the University of Colorado Westminster Family Medicine...
February 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29278971/prevention-strategies-against-hiv-transmission-a-proactive-approach
#10
Antonio J Carrion, Jovan D Miles, Juan F Mosley, Lillian L Smith, April S Prather, Marcus M Gurley, Linh D Phan, Emily C Everton
Human immunodeficiency virus (HIV) has now transformed into a manageable chronic condition. Highly active antiretroviral therapy (HAART) has proven efficacious at controlling the disease progression. Based on compelling evidence, the Department of Health and Human Services (DHHS) and the Infectious Disease Society of America (IDSA) developed guidelines for the management of persons infected with HIV. However, there are approximately 50 000 new cases of HIV in the United States each year. In this article, we review proactive methods to reduce the transmission of HIV, which include reinforcing patient education, gel-coated condoms that destroy HIV, HIV vaccinations, and adequately utilizing pre-exposure prophylaxis (PrEP), and post-exposure prophylaxis (PEP)...
February 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28430016/the-use-of-intravenous-lidocaine-for-the-management-of-acute-pain-secondary-to-traumatic-ankle-injury-a-case-report
#11
Billy Sin, Diana Gritsenko, Grace Tam, Kimberly Koop, Eva Mok
Sports-related injuries are a frequent cause of visits to the emergency department (ED) across the United States. A majority of these injuries affect the lower extremities with the ankle as the most frequently reported site. Most sports-related injuries are not severe enough to require inpatient hospitalization; however, they often lead to acute distress and pain which require prompt treatment with analgesics. Approximately 22% of patients who presented to the ED required pharmacotherapy for acute pain management...
February 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28125922/ace-inhibitor-induced-angioedema-of-the-small-bowel-a-case-report-and-review-of-the-literature
#12
Kent L Wilin, Michael J Czupryn, Richard Mui, Anas Renno, Julie A Murphy
Angiotensin-converting enzyme (ACE) inhibitors are known to cause angioedema. Most ACE inhibitor-induced angioedema cases describe swelling in the periorbital region, tongue, and pharynx. We describe a case of a 62-year-old female with presumed angioedema of the small bowel after more than a 2-year history of lisinopril use (with no recent changes in her dose of 40 mg orally twice daily). The patient presented with nausea and intermittent left middle and upper quadrant abdominal pain and denied history of angioedema or swelling with any medications or any history of abdominal pain...
February 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29673294/prophylactic-use-of-steroids-and-antibiotics-in-acute-hydrocarbon-poisoning-in-children
#13
Saibal Das, Sapan Kumar Behera, Alphienes Stanley Xavier, Sandhiya Selvarajan
Ingestion of hydrocarbons is a common cause of childhood poisoning in low and middle-income countries. Although mild ingestions are usually devoid of complications, the morbidity and mortality associated with such poisoning are primarily related to pulmonary aspiration. Subsequent complications, most importantly, secondary bacterial infections can worsen the clinical condition. Standard treatment protocol for acute accidental hydrocarbon poisoning does not advocate routine use of steroids or antibiotics. However, some studies have demonstrated beneficial effects of prophylactic steroid and antibiotic to prevent chemical pneumonitis...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29673293/systemic-thrombolytic-therapy-for-massive-and-submassive-pulmonary-embolism
#14
Lauren A Igneri, John M Hammer
OBJECTIVE: To critically evaluate the published literature assessing the safety and efficacy of thrombolytic therapy for massive and submassive pulmonary embolism (PE). METHODS: A search of human trials in the English-language (September 2017) was conducted through the MEDLINE database using the following terms: PE, tissue plasminogen activator, tenecteplase, and alteplase. 67 unique articles were identified, of which 24 clinical trials discussing clinical outcomes related to administration of either intravenous tenecteplase or alteplase were included...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29665720/community-pharmacist-preferences-in-transition-of-care-communications
#15
Mackenzie A Dolan, Chelsea P Renfro, Stefanie P Ferreri, Betsy B Shilliday, Timothy J Ives, Jamie J Cavanaugh
OBJECTIVE: To determine community pharmacist preferences in transition of care (TOC) communications. METHODS: In this cross-sectional study, data were gathered via electronic survey of community pharmacists regarding their preferences for TOC communications. The survey was distributed via email by the North Carolina Board of Pharmacy. Results were analyzed using descriptive statistics. RESULTS: Survey responses were received from 343 community pharmacists (response rate = 6...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29665719/hyperinflation-of-isoproterenol
#16
Julie D'Ambrosi, Nilesh Amin
The hyperinflation of isoproterenol, a 75-year-old drug, in early 2015 was unbelievable. The attention of health-care professionals, health system administrators, legislators, and the general public was quickly focused on Valeant Pharmaceuticals, purchaser of several generics solely to raise their price. With isoproterenol easily launched toward the top of drug expenditures, pharmacists in many hospitals were forced to engage stakeholders in the investigation and implementation of alternatives, explore utilization and optimize inventory, reduce cost through sterile product preparation, where possible, restrict use to settings that were beneficial to their budget, and become legislative advocates...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29661063/calcitonin-stewardship-strategies
#17
Steven L Allison, Kevin W Davis
Despite being approved by the Food and Drug Administration for over 30 years, calcitonin salmon has seen a dramatic increase in acquisition cost over the last few years. Being commonly used for the treatment of hypercalcemia of malignancy, health systems must implement stewardship strategies in order to curtail usage. This review is intended to provide a background on calcitonin usage for hypercalcemia of malignancy and associated strategies to ensure appropriateness of utilization within health systems.
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29656678/validation-of-the-meduseq-a-self-administered-screener-for-older-adults-to-assess-medication-use-problems
#18
Rebecca L Berman, Madelyn Iris, Kendon J Conrad, Carrie Robinson
BACKGROUND: Older adults taking multiple prescription and nonprescription drugs are at risk for medication use problems, yet there are few brief, self-administered screening tools designed specifically for them. OBJECTIVE: The study objective was to develop and validate a patient-centered screener for community-dwelling older adults. METHODS: In phase 1, a convenience sample of 57 stakeholders (older adults, pharmacists, nurses, and physicians) participated in concept mapping, using Concept System® Global MAXTM , to identify items for a questionnaire...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29642733/warfarin-patients-with-anemia-show-trend-of-out-of-range-international-normalized-ratio-frequency-with-point-of-care-testing-in-an-anticoagulation-clinic
#19
Christina E DeRemer, Bliss McMichael, Henry N Young
INTRODUCTION: Many factors influence international normalized ratio (INR); however, few studies have examined the impact of anemia in warfarin patients. The primary objective of this study was to explore the relationship between in-clinic anemia and the control of INR within an anticoagulation clinic. METHODS: A retrospective chart review was performed on a random sample of patients seen in an academic medical center pharmacy-managed anticoagulation clinic. Hemochron® Signature Elite machine was utilized to monitor point-of-care (POC) INR...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29642732/evaluation-of-appropriate-sodium-polystyrene-sulfonate-use-with-a-hyperkalemia-order-set-a-pilot-study
#20
Zachary T Mueller, Andrew J Crannage
BACKGROUND: No consensus guidelines exist to assist practitioners in the management of hyperkalemia. Sodium polystyrene sulfonate (SPS) is a common treatment option for hyperkalemia. To aid health-care professionals, a hyperkalemia order set was created at a 979-bed community teaching hospital. OBJECTIVE: The objective of this study was to determine whether use of a hyperkalemia order set is associated with appropriate use of SPS. METHODS: Orders for SPS were evaluated for appropriateness in this retrospective cohort of adult patients...
January 1, 2018: Journal of Pharmacy Practice
journal
journal
30014
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"