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Autoimmunity

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https://www.readbyqxmd.com/read/28749191/disease-related-autoantibody-profile-in-patients-with-systemic-sclerosis
#1
Christos Liaskos, Emmanouela Marou, Theodora Simopoulou, Maria Barmakoudi, Georgios Efthymiou, Thomas Scheper, Wolfgang Meyer, Dimitrios P Bogdanos, Lazaros I Sakkas
BACKGROUND: Autoantibodies (autoAbs) help in diagnosis and predicting clinical phenotypes in systemic sclerosis (SSc). AIM OF THE STUDY: To determine the clinical utility of 13 SSc-related autoAbs in SSc patients. MATERIAL AND METHODS: A total of 131 consecutive patients with SSc (111 female, mean age 58.1 ± 14 years; 49 with diffused cutaneous SSc [dcSSc] and 82 with limited cutaneous SSc [lcSSc]) were analysed by a multiplex line immunoassay (Euroimmun) for autoantibodies (autoAbs) against 13 SSc-related antigens...
July 27, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28737980/nitration-of-h2b-histone-elicits-an-immune-response-in-experimental-animals
#2
Md Asad Khan, Khursheed Alam, Syed Mehdi Hassan, M Moshahid A Rizvi
Histone H2B is an autoantigen that appears in circulation due to altered apoptosis/or insufficient clearance and is likely to be involved in the induction and progression of autoimmune diseases since modified-H2B is immunogenic. Our studies demonstrate that tyrosines of H2B histone spontaneously converts to free and nitrotyrosine bound protein in vivo. Commercially available H2B histone was modified with peroxynitrite in vitro. Modified H2B was found to be more immunogenic than native form in experimental animals...
July 24, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28699799/immunization-of-balb-c-mice-with-pigeon-igy-induces-the-production-of-anti-igg-autoantibodies
#3
Ivan Sammir Aranda-Uribe, Enrique Ortega, Erasmo Martínez-Cordero
The breakdown of immunological tolerance due to the activation of autoreactive B and T cells triggers physiopathological processes. An example of such conditions is the production of IgG autoantibodies specific for the Fc portion of IgG (anti-Fcγ IgG). Previous reports have shown that patients with pigeon-related hypersensitivity pneumonitis exhibit an increase in the serum levels of anti-Fcγ IgG. There is no in vivo model for the study of this condition and the immunological mechanisms of tolerance breakdown associated with sensitization by pigeon antigens are still unknown...
July 12, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28686532/management-of-hydrocephalus-associated-with-autoimmune-diseases-a-series-of-19-cases
#4
Baitao Ma, Hao Wu, Hexiang Yin, Jianbo Chang, Li Wang, Renzhi Wang, Wenbin Ma, Yongning Li, Jian Guan, Jinjing Liu, Junji Wei
OBJECTIVES: To analyze the diagnosis and treatment of hydrocephalus associated with autoimmune diseases and to explore the possible mechanism of hydrocephalus in these patients. METHODS: A retrospective case series study was conducted at Peking Union Medical College Hospital, Beijing, China. Files were retrieved from the hospital archives by screening records from Jan 1990 to Jan 2016. Medical records were screened for data regarding (1) the number of patients diagnosed with hydrocephalus associated with autoimmune diseases, (2) the clinical manifestation of hydrocephalus associated with autoimmune disease, and (3) the outcomes of these patients treated with medication or ventriculoperitoneal shunt (VPS)...
July 7, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28686488/contribution-of-both-b-cell-intrinsic-alterations-as-well-as-non-hematopoietic-derived-factors-in-the-enhanced-immune-response-of-the-nod-mouse
#5
Viqar Showkat Banday, Radha Thyagarajan, Kristina Lejon
The underlying cellular and molecular mechanism for the development of Type 1 diabetes is still to be fully revealed. We have previously demonstrated that the NOD mouse, a model for Type 1 diabetes, display a prolonged and enhanced immune response to both self and non-self-antigens. The molecular explanation for this defect however, has not been determined. In this study we immunized NOD and C57BL/6 (B6) with the conventional antigen i.e. hen egg lysozyme (HEL) and analyzed B cell activation, germinal center reaction and antibody clearance...
July 7, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28686485/impaired-salivary-gland-activity-in-patients-with-autoimmune-polyendocrine-syndrome-type-i
#6
Bergithe E Oftedal, Mihaela Cuida Marthinussen, Martina M Erichsen, Maria K Tveitarås, Anja Kjellesvik-Kristiansen, Daniel Hammenfors, Malin V Jonsson, Kai Kisand, Roland Jonsson, Anette S B Wolff
Autoimmune polyendocrine syndrome type I (APS-I) is a severe disease caused by mutations in the autoimmune regulator (AIRE) gene. We hypothesized that salivary gland dysfunction could be a possible unexplored component of these patients and here aimed to investigate salivary and lachrymal symptoms in the Norwegian cohort of APS-I patients (N = 41) and the aetiology behind it. Sicca symptoms and possible corresponding underlying factors were assessed by subjective reports combined with objective measures of saliva and tear flow, serological testing, immune fluorescence microscopy, ultrasonography and searching for putative autoantibodies in the salivary glands...
July 7, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28686480/caerulomycin-a-suppresses-the-differentiation-of-na%C3%A3-ve-t-cells-and-alleviates-the-symptoms-of-experimental-autoimmune-encephalomyelitis
#7
Weshely Kujur, Rama Krishna Gurram, Sudeep K Maurya, Sajid Nadeem, Sathi Babu Chodisetti, Nargis Khan, Javed Naim Agrewala
Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS. It is characterized by frequent relapses due to the generation of memory T cells. Caerulomycin A (CaeA) is known to suppress the Th1 cells, Th2 cells, and Th17 cells. Interestingly, it enhances the generation of regulatory T cells (Tregs)...
July 7, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28682648/kinase-inhibitors-of-the-igf-1r-as-a-potential-therapeutic-agent-for-rheumatoid-arthritis
#8
Hiroshi Tsushima, Shinji Morimoto, Maki Fujishiro, Yuko Yoshida, Kunihiro Hayakawa, Takuya Hirai, Tomoko Miyashita, Keigo Ikeda, Ken Yamaji, Kenji Takamori, Yoshinari Takasaki, Iwao Sekigawa, Naoto Tamura
We have previously shown that the inhibition of connective tissue growth factor (CTGF) is a potential therapeutic strategy against rheumatoid arthritis (RA). CTGF consists of four distinct modules, including the insulin-like growth factor binding protein (IGFBP). In serum, insulin-like growth factors (IGFs) bind IGFBPs, interact with the IGF-1 receptor (IGF-1 R), and regulate anabolic effects and bone metabolism. We investigated the correlation between IGF-1 and the pathogenesis of RA, and the inhibitory effect on osteoclastogenesis and angiogenesis of the small molecular weight kinase inhibitor of the IGF-1 R, NVP-AEW541, against pathogenesis of RA in vitro...
July 6, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28675715/identification-of-potential-biomarkers-for-systemic-lupus-erythematosus-diagnosis-using-two-dimensional-differential-gel-electrophoresis-2d-dige-and-mass-spectrometry
#9
Tamara Aparecida Reis Ferreira, Hélida Monteiro de Andrade, Paulo Madureira de Pádua, Maria das Graças Carvalho, Simone da Fonseca Pires, Ivana Helena Rocha Oliveira, Bruna Soares Souza Lima, Luis Carlos Fialho Júnior, Walter Batista Cicarini, Donat Alexander Chapeourouge, Jonas Henrique Perales, Tânia Mara Pinto Dabés Guimarães, Vicente de Paulo Coelho Peixoto de Toledo
Systemic lupus erythematosus (SLE) is an autoimmune disease of the connective tissue with a large spectrum of clinical manifestations. Immune deregulation leads to autoantibody and immune complexes overproduction, complement activation, and persistent tissue inflammation. Considering that the current diagnosis depends on the interpretation of the complex criteria established by the American College of Rheumatology and that the disease course is characterized by unpredictable activations and remissions, each patient develops different manifestations, and therefore, the discovery of specific biomarkers is urgently required...
July 4, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28675712/association-of-the-polymorphisms-in-the-gene-encoding-thyroglobulin-with-the-development-and-prognosis-of-autoimmune-thyroid-disease
#10
Tomoyo Mizuma, Mikio Watanabe, Naoya Inoue, Yuya Arakawa, Saki Tomari, Yoh Hidaka, Yoshinori Iwatani
Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid diseases (AITDs), and the prognosis of AITDs is different for each patient. We examined the association of polymorphisms in the Thyroglobulin (TG) gene with the pathogenesis of AITD. We genotyped TG rs180195G/A, rs853326G/A, rs2076740C/T, rs2703013G/T, rs2958692C/T and rs733735A/G polymorphisms in 137 HD patients, 131 GD patients and 89 healthy controls and also examined the levels of TG mRNA expression and serum TG. The TG rs180195 GG genotype was more frequent in HD patients (p = ...
July 4, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28675711/modification-of-anti-tumor-immunity-by-tolerogenic-dendritic-cells
#11
Liying Chen, Mohammad Sharif Hasni, Mikael Jondal, Konstantin Yakimchuk
Immunosuppressive functions of glucocorticoids (GC) can be mediated via various mechanisms, including the modulation of dendritic cells (DC). Our study investigates the effects of tolerogenic GC-treated DCs on NK and T cell anti-tumor responses in OT-1/Rag(-/-) mice, expressing a transgenic TCR in CD8(+) T cells. The effects caused by GC-treated DCs were compared to the responses to immunogenic, CpG-activated DCs. The effects of DCs on anti-tumor immune responses were analyzed using the EG7 tumor model, where the tumor cells express the peptide epitope recognized by OT-1 T cells...
July 4, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28665157/sex-related-differences-in-autoimmune-induced-lung-lesions-in-mrl-mpj-fas-lpr-mice-are-mediated-by-the-development-of-mediastinal-fat-associated-lymphoid-clusters
#12
Yaser Hosny Ali Elewa, Osamu Ichii, Yasuhiro Kon
MRL/MpJ-Fas(lpr) (lpr) mice are a model for autoimmune diseases such as systemic lupus erythematosus (SLE). These diseases mainly affect women, with a 10:1 female-to-male ratio, and cause pleuropulmonary lesions. We previously revealed a correlation between mediastinal fat-associated lymphoid cluster (MFALC) development and cellular infiltration in the lungs of lpr male mice; however, we did not report on MFALCs in females. The purpose of this investigation was to reveal sex-related differences in MFALCs in lpr mice...
June 30, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28648105/abnormal-distribution-of-aqp4-in-minor-salivary-glands-of-primary-sj%C3%A3-gren-s-syndrome-patients
#13
Margherita Sisto, Loredana Lorusso, Giuseppe Ingravallo, Beatrice Nico, Domenico Ribatti, Simona Ruggieri, Dario Domenico Lofrumento, Sabrina Lisi
A decreased saliva production occurs in primary Sjögren's syndrome (pSS), an autoimmune disease characterized by oral and ocular dryness due to dysfunction of the lacrimal and salivary glands (SGs). Since water movement is involved in saliva secretion, the expression, localization, and function of the water channels aquaporins (AQPs) have been extensively studied in SGs. To date, the presence of AQP4 remains controversial and ambiguous in human SGs. We investigated by immunohistochemistry, high-resolution confocal microscopy and quantitative image analysis, Western blot and real-time RT-PCR, the presence of the AQP4 gene, and the distribution of AQP4 protein in healthy controls and pSS SG biopsies...
June 24, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28557628/identification-of-endothelin-converting-enzyme-2-as-an-autoantigen-in-autoimmune-polyendocrine-syndrome-type-1
#14
Casey J A Smith-Anttila, Sophie Bensing, Mohammad Alimohammadi, Frida Dalin, Mikael Oscarson, Ming-Dong Zhang, Jaakko Perheentupa, Eystein S Husebye, Jan Gustafsson, Peyman Björklund, Anette Fransson, Gunnel Nordmark, Lars Rönnblom, Antonella Meloni, Rodney J Scott, Tomas Hökfelt, Patricia A Crock, Olle Kämpe
Autoimmune polyendocrine syndrome type 1 (APS1) is a rare monogenic autoimmune disorder caused by mutations in the autoimmune regulator (AIRE) gene. High titer autoantibodies are a characteristic feature of APS1 and are often associated with particular disease manifestations. Pituitary deficits are reported in up to 7% of all APS1 patients, with immunoreactivity to pituitary tissue frequently reported. We aimed to isolate and identify specific pituitary autoantigens in patients with APS1. Immunoscreening of a pituitary cDNA expression library identified endothelin-converting enzyme (ECE)-2 as a potential candidate autoantigen...
May 30, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28553742/antiribonuclease-h2-antibodies-are-an-immune-biomarker-for-systemic-lupus-erythematosus
#15
Kazuhisa Nozawa, Kentaro Doe, Kaori Uomori, Iwao Sekigawa, Yoshinari Takasaki, Ken Yamaji, Naoto Tamura
We previously reported that autoantibodies against the proliferating cell nuclear antigen protein (PCNA)-binding protein chromatin assembly factor-1 (CAF-1) are specifically found in patients with systemic lupus erythematosus (SLE). PCNA and its complex constituents elicit autoimmune responses in patients with SLE, suggesting that autoantibody diversification likely occurs owing to epitope spreading. Therefore, we sought to clarify whether patients with SLE exhibit an autoimmune response to Ribonuclease H2 (RNase H2), another PCNA-binding protein that regulates cell division...
May 27, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28548588/injection-of-inactive-bordetella-pertussis-and-complete-freund-s-adjuvant-with-torpedo-californica-achr-increases-the-occurrence-of-experimental-autoimmune-myasthenia-gravis-in-c57bl-6-mice
#16
Takahiro Maruta, Minako Oshima, Dennis R Mosier, M Zouhair Atassi
An animal model of myasthenia gravis (MG), termed experimental autoimmune MG (EAMG), is an important tool for investigations of disease mechanisms and/or methods of treatment for this disease. EAMG can be induced in C57BL/6 (B6, H-2(b)) mice by 2-3 times injections at 4 weeks intervals with Torpedo californica (t) acetylcholine receptor (AChR) in complete Freund's adjuvant (CFA). However, the protocol especially with a two-injection schedule occasionally produces a poor incidence of EAMG. We have investigated the efficacy of the additional adjuvant, inactive organisms of Bordetella pertussis (iBP), on the induction with a two-injection schedule...
May 26, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28534443/cd59-polymorphisms-are-associated-with-gene-expression-and-different-sexual-susceptibility-to-pemphigus-foliaceus
#17
Amanda Salviano-Silva, Maria Luiza Petzl-Erler, Angelica Beate Winter Boldt
Pemphigus foliaceus (PF) is an autoimmune disease, endemic in Brazilian rural areas, characterized by acantholysis and accompanied by complement activation, with generalized or localized distribution of painful epidermal blisters. CD59 is an essential complement regulator, inhibiting formation of the membrane attack complex, and mediating signal transduction and activation of T lymphocytes. CD59 has different transcripts by alternative splicing, of which only two are widely expressed, suggesting the presence of regulatory sites in their noncoding regions...
May 23, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28534442/genotype-and-haplotype-analysis-of-abcb1-at-1236-2677-and-3435-among-systemic-sclerosis-patients
#18
Małgorzata Barańska, Mariola Rychlik-Sych, Jadwiga Skrętkowicz, Michał Dudarewicz, Bożena Dziankowska-Bartkowiak, Jacek Owczarek, Elżbieta Waszczykowska
Systemic sclerosis (SSc) belongs to the group of systemic diseases of the connective tissue, which are characterized by a chronic autoimmune inflammatory process. P-glycoprotein, initially associated with the drug resistance in patients with cancer, becomes more and more often a subject of considerations in terms of its significance in the development of illnesses, including autoimmune diseases. The aim of the study was an attempt to answer the question whether there was a relationship between ABCB1 polymorphisms and morbidity of systemic sclerosis in a Polish population...
May 23, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28276715/inflammation-in-sj%C3%A3-gren-s-syndrome-cause-or-consequence
#19
Ana Raquel Rodrigues, Raquel Soares
Sjögren's syndrome (SS) is an autoimmune disease most commonly characterized by ocular and oral dryness. Despite the high prevalence of SS, generation and perpetuation of this disease is still unclear in many aspects. Inflammation, nonetheless, seems to play a central role in this pathology especially in the form of Th-1, Th-2 and Th-17 cytokines release within different aspects, concentrations and connections involved in the maintenance of the syndrome. Moreover, the chronically created pro-inflammatory environment appears to promote glandular atrophy and irreparable architectural modifications...
May 2017: Autoimmunity
https://www.readbyqxmd.com/read/28434265/adipose-tissue-infiltration-in-minor-salivary-glands-of-patients-with-sj%C3%A3-gren-s-syndrome-lack-of-significant-correlation-with-the-disease-an-image-analysis-of-174-cases
#20
Krisztián Katona, Nelli Farkas, Gábor Sütő, Tamás Tornóczky
Fatty infiltration in minor salivary gland biopsies and its correlation to systemic autoimmune diseases are controversial in the literature. Presence and extent of fatty infiltration in minor salivary glands of 107 Sjögren's syndrome patients and 67 age-matched sicca controls were compared with statistical analyses. No significant difference was found regarding the presence or the extent of fatty infiltration between the two groups. Fatty infiltration seems to be unrelated to Sjögren's syndrome thus its examination in salivary gland biopsy samples cannot improve the diagnostic accuracy of the disease...
April 23, 2017: Autoimmunity
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