journal
https://read.qxmd.com/read/38545756/novel-peripheral-blood-mononuclear-cell-mrna-signature-for-ifn-beta-therapy-responsiveness-prediction-in-multiple-sclerosis
#1
JOURNAL ARTICLE
Yang Xue, Pengqi Yin, Hongping Chen, Guozhong Li, Di Zhong
Interferon-beta (IFN-<mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>) is one of the classical drugs for immunomodulatory therapy in relapsing-remitting multiple sclerosis (RRMS) patients, but the drug responsiveness of different patients varies. Currently, there is no valid model to predict IFN-<mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math> responsiveness...
December 2024: Autoimmunity
https://read.qxmd.com/read/38515381/innovate-therapeutic-targets-for-autoimmune-diseases-insights-from-proteome-wide-mendelian-randomization-and-bayesian-colocalization
#2
JOURNAL ARTICLE
Qiubai Jin, Feihong Ren, Ping Song
BACKGROUND: Despite growing knowledge regarding the pathogenesis of autoimmune diseases (ADs) onset, the current treatment remains unsatisfactory. This study aimed to identify innovative therapeutic targets for ADs through various analytical approaches. RESEARCH DESIGN AND METHODS: Utilizing Mendelian randomization, Bayesian co-localization, phenotype scanning, and protein-protein interaction network, we explored potential therapeutic targets for 14 ADs and externally validated our preliminary findings...
December 2024: Autoimmunity
https://read.qxmd.com/read/38497343/the-association-of-25-oh-d-interleukin-4-interleukin-5-and-interleukin-13-levels-with-the-burden-of-soil-transmitted-helminth-infection-in-stunted-children-aged-24-59-months
#3
JOURNAL ARTICLE
Riyadi Adrizain, Monika Verena Nagari, Djatnika Setiabudi, Afiat Berbudi, Budi Setiabudiawan
Soil-transmitted helminth (STH) among children aged 24-59 months is one cause of chronic infection that could lead to stunting. The association of 25(OH)D and immune responses during chronic infection in stunted populations has not yet been well established. An association study of case-control data was conducted in Bandung district from October 2019 to January 2023. Sociodemographic factors, stool samples, and serum levels of 25(OH)D, interleukin-4 (IL-4), interleukin-5 (IL-5), and interleukin-13 (IL-13) were assessed...
December 2024: Autoimmunity
https://read.qxmd.com/read/38477884/animal-models-of-lupus-nephritis-the-past-present-and-a-future-outlook
#4
REVIEW
Divya Katikaneni, Laurence Morel, Yogesh Scindia
Lupus nephritis (LN) is the most severe end-organ pathology in Systemic Lupus Erythematosus (SLE). Research has enhanced our understanding of immune effectors and inflammatory pathways in LN. However, even with the best available therapy, the rate of complete remission for proliferative LN remains below 50%. A deeper understanding of the resistance or susceptibility of renal cells to injury during the progression of SLE is critical for identifying new targets and developing effective long-term therapies. The complex and heterogeneous nature of LN, combined with the limitations of clinical research, make it challenging to investigate the aetiology of this disease directly in patients...
December 2024: Autoimmunity
https://read.qxmd.com/read/38466182/identification-of-macrophage-related-molecular-subgroups-and-risk-signature-in-colorectal-cancer-based-on-a-bioinformatics-analysis
#5
JOURNAL ARTICLE
Qi Liu, Li Liao
Macrophages play a crucial role in tumor initiation and progression, while macrophage-associated gene signature in colorectal cancer (CRC) patients has not been investigated. Our study aimed to identify macrophage-related molecular subgroups and develop a macrophage-related risk model to predict CRC prognosis. The mRNA expression profile and clinical information of CRC patients were obtained from TCGA and GEO databases. CRC patients from TCGA were divided into high and low macrophage subgroups based on the median macrophage score...
December 2024: Autoimmunity
https://read.qxmd.com/read/38465789/functions-of-igm-fc-receptor-fc%C3%A2%C2%B5r-related-to-autoimmunity
#6
REVIEW
Hiromi Kubagawa, Pedram Mahmoudi Aliabadi, Khlowd Al-Qaisi, Peter K Jani, Kazuhito Honjo, Shozo Izui, Andreas Radbruch, Fritz Melchers
Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of autoantibodies of IgM and IgG isotypes. In this essay, we reiterate the autoimmune phenotypes observed in mutant mice, ie IgM homeostasis, dysregulated humoral immune responses including autoantibodies, and Mott cell formation. We also propose the potential phenotypes in individuals with FCMR deficiency and the model for FcµR-mediated regulation of self-reactive B cells...
December 2024: Autoimmunity
https://read.qxmd.com/read/38439147/integrated-bioinformatics-analysis-identifies-autophagy-associated-genes-as-candidate-biomarkers-and-reveals-the-immune-infiltration-landscape-in-psoriasis
#7
JOURNAL ARTICLE
Sixian Bai, Hongyu Cheng, Hao Li, Peng Bo
Autophagy is implicated in the pathogenesis of psoriasis. We aimed to identify autophagy-related biomarkers in psoriasis via an integrated bioinformatics approach. We downloaded the gene expression profiles of GSE30999 dataset, and the "limma" package was applied to identify differentially expressed genes (DEGs). Then, differentially expressed autophagy-related genes (DEARGs) were identified via integrating autophagy-related genes with DEGs. CytoHubba plugin was used for the identification of hub genes and verified by the GSE41662 dataset...
December 2024: Autoimmunity
https://read.qxmd.com/read/38425093/cd5l-induces-inflammation-and-survival-in-ra-fls-through-erk1-2-mapk-pathway
#8
JOURNAL ARTICLE
Huiqing Yang, Yan Luo, Xiaofei Lai
OBJECTIVE: To explore the effect of CD5-like molecule (CD5L) on rheumatoid arthritis (RA) fibroblast-like synoviocytes (RA-FLS) and the relative molecular mechanism of CD5L in it. METHODS: Recombinant protein CD5L was used to stimulate the cultured RA-FLS cells. The inflammation-related cytokines were determined by real time-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). The signal molecules and apoptosis-related molecules were detected by western blot assay (WB), and cell counting kit-8 (CCK-8) was used to detect the proliferation...
December 2024: Autoimmunity
https://read.qxmd.com/read/38409788/identification-of-new-hub-ferroptosis-related%C3%A2-genes-in-lupus-nephritis
#9
JOURNAL ARTICLE
Xiao-Jie Zheng, Ying Chen, Li Yao, Xiao-Li Li, Da Sun, Yan-Qiu Li
Background : Lupus Nephritis (LN) is the primary causation of kidney injury in systemic lupus erythematosus (SLE). Ferroptosis is a programmed cell death. Therefore, understanding the crosstalk between LN and ferroptosis is still a significant challenge. Methods : We obtained the expression profile of LN kidney biopsy samples from the Gene Expression Omnibus database and utilised the R-project software to identify differentially expressed genes (DEGs). Then, we conducted a functional correlation analysis. Ferroptosis-related genes (FRGs) and differentially expressed genes (DEGs) crossover to select FRGs with LN...
December 2024: Autoimmunity
https://read.qxmd.com/read/38404066/dysregulated-cxcl12-expression-in-osteoblasts-promotes-b-lymphocytes-preferentially-homing-to-the-bone-marrow-in-mrl-lpr-mice
#10
JOURNAL ARTICLE
Wenjuan Zheng, Yu Tang, Mengwei Cheng, Cui Ma, Xiaoming Fei, Wei Shi
Objective: Todetect the abnormal distribution of B-lymphocytes between peripheral and bone marrow (BM) compartments and explore the mechanism of abnormal chemotaxis of B-lymphocytes in lupus subjects. Methods: The proportions of CXC chemokine receptor (CXCR)4+ B cells and CFDA-labeled MRL/lpr-derived B cells were detected by flow cytometry. The levels of CXC chemokine ligand (CXCL)12in peripheral blood (PB)were measured by ELISA. The migrated B cells to osteoblasts (OBs) was measured by transwell migration assay...
December 2024: Autoimmunity
https://read.qxmd.com/read/38389178/ogt-induced-o-glcnacylation-of-nek7-protein-aggravates-osteoarthritis-progression-by-enhancing-nek7-nlrp3-axis
#11
JOURNAL ARTICLE
Chunlei He, Qiang Wu, Zhaogan Zeng, Yadong Yang, Huabin He, Meiyu Hu, Sheng Liu
BACKGROUNDS: The role of O-GlcNAc transferase (OGT)-induced O-linked N-acetylglucosaminylation (O-GlcNAcylation) has been reported in multiple human diseases. However, its specific functions in osteoarthritis (OA) progression remain undetermined. OBJECTIVE: This study focused on the target proteins of OGT-induced O-GlcNAcylation in OA and the specific functional mechanism. METHODS: The levels of total O-GlcNAc and OGT were measured in both in vitro and in vivo OA models using western blot...
December 2024: Autoimmunity
https://read.qxmd.com/read/38389171/effects-of-autoimmune-abnormalities-on-fertility-and-placental-morphology-in-mice
#12
JOURNAL ARTICLE
Risa Yamanaka, Osamu Ichii, Teppei Nakamura, Yuki Otani, Takashi Namaba, Yasuhiro Kon
Autoimmune diseases (AIDs) alter the placental immune environment leading to fetal loss. This study investigated the effects of AIDs on pregnancy and the placenta in AID-prone MRL/MpJ- Faslpr/lpr mice and wild-type MRL/MpJ, which were mated with male MRL/MpJ and MRL/MpJ- Faslpr/lpr at five months and defined as moLpr and moMpJ, respectively. AID indices (spleen weight and serum autoantibody levels) and fertility status (number and size of fetuses, morphology, and comprehensive gene expression of placentas) were evaluated on gestational day 15...
December 2024: Autoimmunity
https://read.qxmd.com/read/38377122/research-progress-in-the-construction-of-animal-models-of-autoimmune-thyroiditis
#13
REVIEW
Ke Liu, Pei Zhang, Ling Zhou, Lin Han, Linhua Zhao, Xiaotong Yu
Autoimmune thyroiditis (AIT), also known as Hashimoto's thyroiditis (HT), is an autoimmune disease that is characterised by elevated thyroid-specific antibody titres. The incidence of AIT is increasing year over year, making it urgent to establish a suitable animal model for this condition, in order to better explore its pathogenesis and potential pharmaceutical mechanisms for treatment. Owing to a lack of basic research on this disease, problems such as disparate modelling methods with unclear and varying success rates make it difficult for researchers to obtain effective information on AIT in the short term...
December 2024: Autoimmunity
https://read.qxmd.com/read/38347676/single-cell-analysis-with-childhood-and-adult-systemic-lupus-erythematosus
#14
JOURNAL ARTICLE
Jing Wang, Xiran Yang, Yanhua Zhang, Xuemei Jiang, Yanfang Li, Jingjing Cui, Yabin Liao
Patients with systemic lupus erythematosus (SLE), a heterogeneous and chronic autoimmune disease, exhibit unique changes in the complex composition and transcriptional signatures of peripheral blood mononuclear cells (PBMCs). While the mechanism of pathogenesis for both childhood-onset SLE (cSLE) and adult-onset SLE (aSLE) remains unclear, cSLE patients are considered more unpredictable and dangerous than aSLE patients. In this study, we analysed single-cell RNA sequencing data (scRNA-seq) to profile the PBMC clusters of cSLE/aSLE patients and matched healthy donors and compared the PBMC composition and transcriptional variations between the two groups...
December 2024: Autoimmunity
https://read.qxmd.com/read/38332696/the-role-of-nlrp3-inflammasome-in-type-2-inflammation-related-diseases
#15
REVIEW
Shenming Xu, Dan Wang, Lina Tan, Jianyun Lu
Type 2 inflammation related diseases, such as atopic dermatitis, asthma, and allergic rhinitis, are diverse and affect multiple systems in the human body. It is common for individuals to have multiple co-existing type 2 inflammation related diseases, which can impose a significant financial and living burden on patients. However, the exact pathogenesis of these diseases is still unclear. The NLRP3 inflammasome is a protein complex composed of the NLRP3 protein, ASC, and Caspase-1, and is activated through various mechanisms, including the NF-κB pathway, ion channels, and lysosomal damage...
December 2024: Autoimmunity
https://read.qxmd.com/read/38332666/bioinformatics-and-systems-biology-approach-to-identify-common-pathogenic-mechanisms-for-covid-19-and-systemic-lupus-erythematosus
#16
JOURNAL ARTICLE
Yinlan Wu, Yanhong Li, Yu Zhou, Xiufeng Bai, Yi Liu
BACKGROUND: The Coronavirus disease 2019 (COVID-19) pandemic has brought a heavy burden to the world, interestingly, it shares many clinical symptoms with systemic lupus erythematosus (SLE). It is unclear whether there is a similar pathological process between COVID-9 and SLE. In addition, we don't know how to treat SLE patients with COVID-19. In this study, we analyse the potential similar pathogenesis between SLE and COVID-19 and explore their possible drug regimens using bioinformatics and systems biology approaches...
December 2024: Autoimmunity
https://read.qxmd.com/read/38321980/circ_0036490-and-dkk1-competitively-bind-mir-29a-to-promote-lipopolysaccharides-induced-human-gingival-fibroblasts-injury
#17
JOURNAL ARTICLE
Yeke Wu, Bin Li, Disi Deng, Hongling Zhou, Min Liu, Huangping Ai, Yilin Xin, Weihan Hua, Lixing Zhao, Li Li
MicroRNA (miRNA) plays a regulatory role in periodontitis. This study aimed to explore whether miR-29a could affect lipopolysaccharides (LPSs)-induced injury in human gingival fibroblasts (HGFs) through the competitive endogenous RNAs (ceRNA) mechanism. Periodontal ligament (PDL) tissues and HGFs were derived from patients with periodontitis and healthy volunteers. Periodontitis cell model was established by treating HGFs with LPS. Expression levels of circ_0036490, miR-29a, and DKK1 were evaluated by the reverse transcription quantitative real-time PCR (RT-qPCR) method...
December 2024: Autoimmunity
https://read.qxmd.com/read/38269483/circnrip1-promotes-proliferation-migration-and-phenotypic-switch-of-ang-ii-induced-ha-vsmcs-by-increasing-cxcl5-mrna-stability-via-recruiting-igf2bp1
#18
JOURNAL ARTICLE
Xianzhao Cao, Hongyan Fang, Longshu Zhou
Circular RNA (circRNA) has been found to be differentially expressed and involved in regulating the processes of human diseases, including thoracic aortic dissection (TAD). However, the role and mechanism of circNRIP1 in the TAD process are still unclear. GEO database was used to screen the differentially expressed circRNA and mRNA in type A TAD patients and age-matched normal donors. Angiotensin II (Ang II)-induced human aortic vascular smooth muscle cells (HA-VSMCs) were used to construct TAD cell models...
December 2024: Autoimmunity
https://read.qxmd.com/read/38254314/circ_0011058-alleviates-ra-pathology-through-the-circ_0011058-mir-335-5p-cul4b-signal-axis
#19
JOURNAL ARTICLE
Xiaomei Wang, Qiuyun Xue, Qiangjun Duan, Ziyi Sun, Yajie Wu, Shuo Yang, Pengfei Xu, Huibo Cao, Faxue Liao, Xiao Wang, Chenggui Miao
Our previous study found that Cullin 4B (CUL4B) inhibited rheumatoid arthritis (RA) pathology through glycogen synthase kinase-3beta (GSK3β)/canonical Wnt signalling pathway. In this work, pre-experiment and bioinformatics analysis suggested that circ_0011058 may lead to the up-regulation of CUL4B expression by inhibiting miR-335-5p. Therefore, we studied whether circ_0011058 can promote the expression of CUL4B through sponging the miR-335-5p and further promote the pathological development of RA. Bioinformatics prediction, real-time quantitative PCR (RT-qPCR), western blot (WB), double luciferase reporter gene and other relevant methods were used to study the inhibition of circ_0011058 on RA pathology and its molecular mechanism...
December 2024: Autoimmunity
https://read.qxmd.com/read/38155490/kiss-1-knockdown-inhibits-cell-growth-migration-and-invasion-in-htr-8-svneo-cells-by-regulating-the-grp54-mediated-pi3k-akt-signaling-pathway
#20
JOURNAL ARTICLE
Lingna Chen, Yuying Ruan, Liping Ni, Guiting Wang, Yajuan Gao, Jindi Zhang, Dingheng Li, Haiou Xu
Recurrent spontaneous abortions (RSA) affect reproductive health and increase the risk of subsequent abortions. To investigate the role of KISS-1/GPR-54 signaling in RSA progression. Villus tissue was collected from RSA patients, and human trophoblastic HTR-8/SVneo cells were used. KISS-1 and GRP54 levels were detected using RT-qPCR and immunohistochemistry. Western blotting was performed to analyze ZO-1 and ZEB1 levels. Cell proliferation was determined via CCK-8 and cell clone formation assays. Transwell assays were performed to assess cell migration and invasion abilities...
December 2024: Autoimmunity
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