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Journal of Biomaterials Applications

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https://www.readbyqxmd.com/read/28622746/sol-gel-derived-lithium-releasing-glass-for-cartilage-regeneration
#1
Siwei Li, Anthony Lb Maçon, Manon Jacquemin, Molly M Stevens, Julian R Jones
Wnt-signalling cascade is one of the crucial pathways involved in the development and homeostasis of cartilage. Influencing this pathway can potentially contribute to improved cartilage repair or regeneration. One key molecular regulator of the Wnt pathway is the glycogen synthase kinase-3 enzyme, the inhibition of which allows initiation of the signalling pathway. This study aims to utilise a binary SiO2-Li2O sol-gel derived glass for controlled delivery of lithium, a known glycogen synthase kinase-3 antagonist...
July 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28517978/the-effect-of-carbon-nanoparticles-on-biological-properties-of-polyester-nanocomposites
#2
Zygmunt Staniszewski, Agnieszka Piegat, Wieslawa Okroj, Magdalena Walkowiak-Przybylo, Witold Jakubowski, Bogdan Walkowiak, Boguslaw Budner, Waldemar Mroz, Peter Sobolewski, Miroslawa El Fray
The aim of present study was to determine the hemocompatibility, cellular response of endothelial cells and bacterial adhesion to a new polyester nanocomposite. The carbon nanoparticle nanocomposite was prepared via in situ polymerization of monomers to obtain material of hardness 55 Sh D similar to polyurethanes used in medical applications, for example, in heart-assisting devices. The carbon nanoparticle-containing polyester exhibits markedly reduced bacterial colonization, as compared to commercially available polyurethanes...
May 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28517977/injectable-chelate-setting-hydroxyapatite-cement-prepared-by-using-chitosan-solution-fabrication-material-properties-biocompatibility-and-osteoconductivity
#3
Toshiisa Konishi, Michiyo Honda, Masaki Nagaya, Hiroshi Nagashima, Eng San Thian, Mamoru Aizawa
An injectable chelate-setting hydroxyapatite cement (IP6-HAp), formed by chelate-bonding capability of inositol phosphate (IP6), was developed. The effects of ball-milling duration of starting HAp powder and IP6 concentration on the material properties such as injectability and mechanical strength of the cement were examined. The cement powder was prepared by ball-milling the as-synthesized HAp powder for 5 min using ZrO2 beads with a diameter of 10 mm, followed by another 60 min with ZrO2 beads with a diameter of 2 mm, and thereafter surface-modified with 5000 ppm of IP6 solution...
May 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28517976/fabrication-of-micropatterns-on-polypropylene-films-via-plasma-pretreatment-combined-with-uv-initiated-graft-polymerization
#4
Liu Jiang, Huaming Qian, Gang Chen, Chunyan Li, Guangjun Yan, Yanling Luo, Peng Liu, Yashao Chen
In this study, micropatterns on polypropylene films were fabricated via plasma pretreatment and UV-initiated graft polymerization. Firstly, radio-frequency plasma, which does not significantly influence bulk attributes of substrates due to limited penetration depth, was utilized to activate polypropylene films. Then, different sizes of micropatterns of poly(hydroxyethyl methacrylate) (PHEMA) were fabricated on the polypropylene films via UV-initiated graft polymerization of hydroxyethyl methacrylate by using photo-masks...
May 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28447548/preparation-of-wormlike-polymeric-nanoparticles-coated-with-silica-for-delivery-of-methotrexate-and-evaluation-of-anticancer-activity-against-mcf7-cells
#5
Farhad Gharebaghi, Naser Dalali, Ebrahim Ahmadi, Hossein Danafar
Methotrexate is one of the most effective drugs that is commonly used in the treatment of cancer. However, its application is limited due to low solubility, high toxicity and rapid metabolism. Therefore, in the present study, worm-like polymeric nanoparticles as carrier of methotrexate were prepared using biodegradable copolymers (mPEG-PCL). The impact of nanoparticles' geometry on the loading, delivery and drug's anti-cancer activity was investigated. The di-block copolymer mPEG-PCL was being synthesized by a ring opening polymerization of ɛ-caprolactone in the presence of mPEG as the initiator and Sn(oct)2 as the catalyst...
April 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28447547/urinary-bladder-extracellular-matrix-hydrogels-and-matrix-bound-vesicles-differentially-regulate-central-nervous-system-neuron-viability-and-axon-growth-and-branching
#6
Anne Faust, Apoorva Kandakatla, Yolandi van der Merwe, Tanchen Ren, Luai Huleihel, George Hussey, Juan Diego Naranjo, Scott Johnson, Stephen Badylak, Michael Steketee
Central nervous system neurons often degenerate after trauma due to the inflammatory innate immune response to injury, which can lead to neuronal cell death, scarring, and permanently lost neurologic function. Extracellular matrix bioscaffolds, derived by decellularizing healthy tissues, have been widely used in both preclinical and clinical studies to promote positive tissue remodeling, including neurogenesis, in numerous tissues, with extracellular matrix from homologous tissues often inducing more positive responses...
April 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28447546/application-of-an-indicator-immobilized-gel-sheet-for-measuring-the-ph-surrounding-a-calcium-phosphate-based-biomaterial
#7
Taisuke Masuda, Hisataka Maruyama, Fumihito Arai, Takahisa Anada, Kaori Tsuchiya, Toshio Fukuda, Osamu Suzuki
The present study was designed to investigate the local microenvironment of octacalcium phosphate in a granule form upon biomolecules adsorption utilizing an indicator-immobilized-gel-sheet for measuring pH. We previously showed that octacalcium phosphate enhances bone regeneration during its progressive hydrolysis into hydroxyapatite if implanted in bone defects. The gel-sheet was made from a photocrosslinkable prepolymer solution, which can easily immobilize a pH indicator (bromothymol blue; BTB) in the hydrogel...
April 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28274194/the-combined-effects-of-nanotopography-and-sr-ion-for-enhanced-osteogenic-activity-of-bone-marrow-mesenchymal-stem-cells-bmscs
#8
Dandan Hu, Kai Li, Youtao Xie, Houhua Pan, Jun Zhao, Liping Huang, Xuebin Zheng
Both surface topography and chemistry have a significant influence on the biological performance of orthopedic implant coatings. In our study, a surface modification strategy embodying bioactive trace element incorporation and nanotopography construction was employed to enhance the osteogenic activity of calcium silicate (Ca-Si) coatings. We developed strontium-loaded nanolayer on plasma sprayed Ca-Si (CS) coating via hydrothermal treatment which was denoted as Sr-NT-CS. The original CS coating and the CS coating modified with similar nanotopography (NT-CS) were studied in parallel...
March 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28274193/a-peptide-based-biological-coating-for-enhanced-corrosion-resistance-of-titanium-alloy-biomaterials-in-chloride-containing-fluids
#9
Noah Muruve, Yuanchao Feng, Jaye Platnich, Daniel Hassett, Randall Irvin, Daniel Muruve, Frank Cheng
Titanium alloys are common materials in the manufacturing of dental and orthopedic implants. Although these materials exhibit excellent biocompatibility, corrosion in response to biological fluids can impact prosthesis performance and longevity. In this work, a PEGylated metal binding peptide (D-K122-4-PEG), derived from bacteria Pseudomonas aeruginosa, was applied on a titanium (Ti) alloy, and the corrosion resistance of the coated alloy specimen was investigated in simulated chloride-containing physiological fluids by electrochemical impedance spectroscopy and micro-electrochemical measurements, surface characterization, and biocompatibility testing...
March 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28274192/immersed-multilayer-biodegradable-ureteral-stent-with-reformed-biodegradation-an-in-vitro-experiment
#10
Ganggang Yang, Hua Xie, Yichen Huang, Yiqing Lv, Mingqing Zhang, Yafeng Shang, Junmei Zhou, Liping Wang, Jin-Ye Wang, Fang Chen
Objective The aim of this study was to develop a novel immersed multilayer biodegradable ureteral stent with reformed biodegradation and evaluate it in vitro. Methods Poly(glycolic-co-lactic acid) (PGLA), microsphere zein and BaSO4 were employed to produce a multilayer biodegradable stent using immersion technology. Tests of the biodegradable stents and conventional control stents were conducted in human urine in vitro to evaluate the biodegradable properties. The biocompatibility was assessed by the morphology and proliferation of urine-derived cells cultured with extracted media from the biodegradable stent and a latex material positive control...
March 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28178904/cit-cus-fe3o4-based-and-enzyme-responsive-magnetic-nanoparticles-for-tumor-chemotherapy-photothermal-and-photodynamic-therapy
#11
Xiali Zhu, Heqing Huang, Yingjie Zhang, Huijuan Zhang, Lin Hou, Zhenzhong Zhang
Safe and efficient drug delivery in a controllable fashion, especially remote and repeatable switch of on-demand drug release, is the subject of widespread attention. A kind of magnetic nanoparticles (DOX-Cit/CuS@Fe3O4-NPs) simultaneously consisted of Cit/CuS@Fe3O4 and doxorubicin (DOX) was presented. The drug release from DOX-Cit/CuS@Fe3O4-NPs could be successfully triggered by the presence of gelatinase, showing great promise for tumor-targeted drug release through an enzymatic degradation mechanism. Compared with free DOX, DOX-Cit/CuS@Fe3O4-NPs could not only specially deliver Cit/CuS@Fe3O4 and DOX into MCF-7 cells, but also could greatly improve the quantity of ROS produced in MCF-7 cells under of 980 nm laser irradiation...
February 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28178903/polymeric-micelles-based-on-pegylated-chitosan-g-lipoic-acid-as-carrier-for-efficient-intracellular-drug-delivery
#12
Gongyan Liu, Kaijun Li, Haibo Wang
To develop a drug delivery system with long circulation and controlled drug release in cancer cells, polymeric micelles based on PEGylated chitosan-g-lipoic acid were prepared to use as a drug delivery platform. These micelles possessed good stability and were stable in physiological environment and high salt concentrations. The in vitro drug release results implied that the drug carrier could maintain their stability and minimize the payload leakage in systemic circulation, but release drugs faster under intracellular redox condition...
February 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28178902/nanobiomaterials-applications-in-neurodegenerative-diseases
#13
Daniela Silva Adaya, Lucinda Aguirre-Cruz, Jorge Guevara, Emma Ortiz-Islas
The blood-brain barrier is the interface between the blood and brain, impeding the passage of most circulating cells and molecules, protecting the latter from foreign substances, and maintaining central nervous system homeostasis. However, its restrictive nature constitutes an obstacle, preventing therapeutic drugs from entering the brain. Usually, a large systemic dose is required to achieve pharmacological therapeutic levels in the brain, leading to adverse effects in the body. As a consequence, various strategies are being developed to enhance the amount and concentration of therapeutic compounds in the brain...
February 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28178901/cellular-interaction-influenced-by-surface-modification-strategies-of-gelatin-based-nanoparticles
#14
Wai Hei Tse, Laszlo Gyenis, David W Litchfield, Jin Zhang
Theranostic applications of gelatin nanospheres require two major components, a method of detection and good biocompatibility. We characterized the response of UTA-6 human osteosarcoma cells to the introduction of functionalized 90 bloom-based gelatin nanospheres (158 ± 49 nm) modified with three elements in different order: (a) hybridization with cadmium-based quantum dots for optical detection, (b) bioconjugation with anti-human IgG FAB (anti-IgG) for cell targeting, with/without (c) capping with polyethylene glycol on the surface for enhanced biocompatibility...
February 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28077052/examinations-of-a-new-long-term-degradable-electrospun-polycaprolactone-scaffold-in-three-rat-abdominal-wall-models
#15
Hanna Jangö, Søren Gräs, Lise Christensen, Gunnar Lose
Alternative approaches to reinforce native tissue in reconstructive surgery for pelvic organ prolapse are warranted. Tissue engineering combines the use of a scaffold with the regenerative potential of stem cells and is a promising new concept in urogynecology. Our objective was to evaluate whether a newly developed long-term degradable polycaprolactone scaffold could provide biomechanical reinforcement and function as a scaffold for autologous muscle fiber fragments. We performed a study with three different rat abdominal wall models where the scaffold with or without muscle fiber fragments was placed (1) subcutaneously (minimal load), (2) in a partial defect (partial load), and (3) in a full-thickness defect (heavy load)...
February 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28077051/facile-preparation-of-antibacterial-highly-elastic-silvered-polyurethane-nanofiber-fabrics-using-silver-carbamate-and-their-dermal-wound-healing-properties
#16
Suk-Min Hong, Jong-Wan Kim, Jonathan C Knowles, Myoung-Seon Gong
In this study, polycarbonate diol/isosorbide-based antibacterial polyurethane nanofiber fabrics containing Ag nanoparticles were prepared by electrospinning process. Bio-based highly elastic polyurethane was prepared from hexamethylene diisocyanate and isosorbide/polycarbonate diol (8/2) by a simple one-shot bulk polymerization. Ag nanoparticles were formed using simple thermal reduction of silver 2-ethylhexylcarbamate at 120℃. The structural and morphological properties of polyurethane/Ag nanofibers were characterized by X-ray diffraction and scanning electron microscopy...
February 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28077049/evaluation-on-biological-compatibility-of-carboxymethyl-chitosan-as-biomaterials-for-antitumor-drug-delivery
#17
Zhiwen Jiang, Baoqin Han, Wanshun Liu, Yanfei Peng
Carboxymethyl-chitosan, a water-soluble derivative of chitosan, has emerged as a promising candidate for biomedical applications due to its excellent water solubility, biodegradation, biocompatibility, hydrating, antimicrobial, and nontoxicity. In this paper, the antitumor proliferation and metastasis was studied in vitro and in vivo to evaluate biocompatibility of carboxymethyl-chitosan as biomaterials for antitumor drug delivery. The results showed that carboxymethyl-chitosan could significantly reduce the clone formation and tumor migration of human cancer cells including kidney cancer cell line OS-RC-2, gastric cancer cell line SGC-7901, colon cancer cell line HT-29, and nonsmall cell lung cancer cell line NCI-H1650 in vitro...
February 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28068861/a-reformative-shear-precipitation-procedure-for-the-fabrication-of-vancomycin-loaded-poly-lactide-co-glycolide-microspheres
#18
Lei Wang, Qinmeng Yang, Yirong Chen, Yu Chai, Jiao Jiao Li, Lin Du, Ruizhe Tan, Shenyu Yang, Mei Tu, Bin Yu
This study reports the encapsulation of vancomycin, as a model hydrophilic drug, into poly(lactide-co-glycolide) microspheres using a novel reformative shear precipitation procedure. In contrast to the external aqueous phase used in the conventional microencapsulation technique based on emulsion solvent evaporation/extraction, the reformative shear precipitation procedure explored in this study uses a shear medium composed of glycerol as the viscous medium and ethanol as polymer antisolvent, which is relatively immiscible with the hydrophilic drug...
February 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28056602/the-potential-of-stromal-cell-derived-factor-1-delivery-using-a-collagen-membrane-for-bone-regeneration
#19
Tadahiro Takayama, Jisen Dai, Keita Tachi, Ryutaro Shohara, Hironori Kasai, Kentaro Imamura, Seiichi Yamano
Stromal cell-derived factor-1 (SDF-1) is a cytokine that is important in stem and progenitor cell recruitment in tissue repair after injury. Regenerative procedures using collagen membranes (CMs) are presently well established in periodontal and implant dentistry. The objective of this study is to test the subsequent effects of the released SDF-1 from a CM on bone regeneration compared to platelet-derived growth factor (PDGF) in vitro and in vivo. For in vitro studies, cell proliferation, alkaline phosphatase activity, and osteoblastic differentiation marker genes were assessed after MC3T3-E1 mouse preosteoblasts were cultured with CMs containing factors...
February 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/27932702/incorporation-of-cerium-oxide-into-hydroxyapatite-coating-regulates-osteogenic-activity-of-mesenchymal-stem-cell-and-macrophage-polarization
#20
Kai Li, Qingyi Shen, Youtao Xie, Mingyu You, Liping Huang, Xuebin Zheng
Biomedical coatings for orthopedic implants should facilitate osseointegration and mitigate implant-induced inflammatory reactions. Cerium oxide (CeO2) ceramics possess anti-oxidative properties and can be used to decrease mediators of inflammation, which makes them attractive for biomedical applications. In our work, two kinds of CeO2 incorporated hydroxyapatite coatings (HA-10Ce and HA-30Ce) were prepared via plasma spraying technique and the effects of CeO2 addition on the responses of bone mesenchymal stem cells (BMSCs) and RAW264...
February 2017: Journal of Biomaterials Applications
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