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Journal of Biomaterials Applications

Qiang Fu, Huaijuan Ren, Chen Zheng, Chao Zhuang, Tong Wu, Jinyan Qin, Zejian Wang, Yantian Chen, Nianmin Qi
Dental pulp stem cell is a new type of mesenchymal stem cell that has a potential for tissue regeneration. Gelatin sponges are often used for hemostasis in dental surgery. In this study, we aimed to evaluate the dental pulp stem cells' proliferation and osteogenic differentiation in different layer-by-layer-modified gelatin sponge scaffolds including the G, G + P (gelatin sponge+ poly-l-lysine modification), G + M (gelatin sponge + mineralization modification), and G + M + P (gelatin sponge + mineralization modification + poly-l-lysine modification) groups in vitro and assessed them in vivo...
September 14, 2018: Journal of Biomaterials Applications
Sahar Balagholi, Mozhgan Rezaei Kanavi, Shaban Alizadeh, Rasul Dabbaghi, Samira Karami, Bahareh Kheiri, Narsis Daftarian
This study was conducted to examine morphological, genotypic, and phenotypic alterations occurring in cultured adult human retinal pigment epithelial cells when encapsulated with different concentrations of fibrin glue. Cultivated adult human retinal pigment epithelial cells were encapsulated with different concentrations of fibrin glue, namely FG1 (42 mg/dl), FG2 (84 mg/dl), FG3 (124 mg/dl), FG4 (210 mg/dl), followed by the evaluation of genetic and cytomorphological changes and protein expression...
September 13, 2018: Journal of Biomaterials Applications
Yude Liu, Lian Rao, Hongguan Zhang, Yanyou Cen, Kaili Cheng
Herb borneol is usually used in clinics for the treatment of central nervous system illness, for its ability of blood-brain barrier permeability, although its poor water solubility and poor bioavailability limit its clinical application to some degree. In this study, we developed a novel nanoparticle combining the benefits of vitamin E d-ɑ-tocopheryl poly(ethylene glycol) succinate (E-TPGS) (or TPGS) and guar gum to get TPGS-g-guar gum as a drug delivery system to carry borneol, which could improve the solubility of borneol and increase the drug-loading capacity efficiently...
September 12, 2018: Journal of Biomaterials Applications
Ashley E Mohrman, Mahmoud Farrag, Rachel K Grimm, Nic D Leipzig
The goal of the present work was to characterize a hydrogel material for localized spinal cord delivery. To address spinal cord injuries, an injectable in situ gelling system was tested utilizing a simple, effective, and rapid cross-linking method via Michael addition. Thiolated chitosan material and maleimide-terminated polyethylene glycol material were mixed to form a hydrogel and evaluated in vitro and in vivo. Three distinct thiolated chitosan precursors were made by varying reaction conditions; a modification of chitosan with Traut's reagent (2-iminothiolane) displayed the most attractive hydrogel properties once mixed with polyethylene glycol...
August 15, 2018: Journal of Biomaterials Applications
Z Ahmadi, D Jha, B Kumar, H K Gautam, Pradeep Kumar
In this study, we have designed and developed two series of bifunctional conjugates by tethering polyethylenimine with streptomycin. By varying the amount of streptomycin, conjugates, polyethylenimine-streptomycin, have been synthesized and characterized spectroscopically. Gel electrophoresis assay revealed a slight decrease in the cationic charge density on the conjugates as these retarded the mobility of pDNA at higher w/w ratios. Further, transfection studies showed that both the series of conjugates transfected the mammalian cells efficiently with low-molecular weight polyethylenimine-streptomycin conjugates were more competent (∼9-fold enhancement with respect to native bPEI) exhibiting high cell viability too...
August 13, 2018: Journal of Biomaterials Applications
Lu Jin, Lei Yao, Yan Zhou, Guangcheng Dai, Wenfang Zhang, Boxin Xue
Ureteral stents are widely used in the department of urology, while the stent could result in many stent-associated complications, such as encrustation, a forgotten stent and patient discomfort. Thus, we developed a novel gradient degradable ureteral stent, which could degrade gradient in vivo, and assessed its effectiveness of the drainage, degradation and biocompatibility in a beagle dog model. In the present study, the degradation time and cytotoxicity were investigated in vitro. And the beagle dogs were inserted with a degradable stent or a biostable stent, and blood studies, liver function tests, renal function tests, urine studies, X-ray, excretory urograms and computerized tomography were performed at immediately, two weeks, four weeks and six weeks postoperative...
August 8, 2018: Journal of Biomaterials Applications
Dong Xie, Leah Howard, Rashed Almousa
Antimicrobial surface is important for the inhibition of bacteria or biofilm formation on biomaterials. The objective of this study was to immobilize a novel hydrophilic polymer containing the antibacterial moiety onto polyurethane surface via a simple surface coating technology to make the surface not only antibacterial but also antifouling. The compound 3,4-dichloro-5-hydroxy-2(5H)-furanone was derivatized, characterized and incorporated onto polyvinylpyrrolidone containing succinimidyl functional groups, followed by coating onto the polyurethane surface...
August 8, 2018: Journal of Biomaterials Applications
Alaa Aldaadaa, Mustafa Al Qaysi, George Georgiou, Rachel Ma Leeson, Jonathan C Knowles
Phosphate glass is continuing to gain more attention as potential bone substitutes. The ternary (P2 O5 -CaO-Na2 O) is investigated in terms of both physical properties and biocompatibility by doping different percentages of SiO2 and TiO2 . Two groups were prepared; the first has different percentages of TiO2 and SiO2 , whereas the second group compositions have 5 mol% TiO2 and 5 mol% SiO2 being added to compensate the network-forming oxide P2 O5 and the network-modifying oxide CaO. Density, mass loss, pH, DTA, XRD, and cation release experiments were performed to study the physicochemical properties of the compositions, while MG63 and hMS cells were used within in vitro cell culture to study their biocompatibility...
August 2018: Journal of Biomaterials Applications
Ryo Mizuta, Tetsushi Taguchi
Hemorrhaging often occurs during cardiac surgery, and postoperative bleeding is associated with medical complications or even death. Medical complications resulting from hemorrhaging can lead to longer hospital stays, thus increasing costs. Hemostatic agents are the main treatment for bleeding. In the present study, hemostatic agents composed of aldehyde groups and hydrophobically modified with hyaluronic acid (ald-hm-HyA) and hydrophobically modified gelatin (hm-ApGltn) were developed and their hemostatic effects were evaluated...
August 2018: Journal of Biomaterials Applications
Tuck-Yun Cheang, Yi-Yan Lei, Zhan-Qiang Zhang, Hong-Yan Zhou, Run-Yi Ye, Ying Lin, Shenming Wang
Gene therapy with herpes simplex virus thymidine kinase gene (HSV-TK), which is also known as "suicide" gene therapy, is effective in various tumor models. The lack of a safe and efficient gene delivery system has become a major obstacle to "suicide" gene therapy. In this study, the cytotoxicity and transfection efficiency of graphene oxide-hydroxyapatite (GO-Hap) were analyzed by MTS and flow cytometry, respectively. A series of assays were performed to evaluate the effects of GO-HAp/p-HRE/ERE-Sur-TK combined with ganciclovir treatment on growth of human breast normal and cancer cells...
August 2018: Journal of Biomaterials Applications
S S Patil, K C Nune, Rdk Misra
A covalently cross-linked injectable hybrid hydrogel, namely, alginate/poly(amidoamine) (PAMAM), with the objective of cell delivery was innovatively designed and synthesized using tetra-amino-functional PAMAM dendrimer as the cross-linker. With the increase in percentage of PAMAM cross-linker, the pore size and swelling ratio of hydrogels were in the range of 57 ± 18 μm to 88 ± 25 μm and 110 ± 16 to 157 ± 20, respectively. The study of attachment and proliferation of MC3T3-E1 pre-osteoblasts using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay through indirect and direct contact methods indicated a continuous increase in metabolically active live cells with time, implying non-cytotoxicity of the synthesized hydrogel...
August 2018: Journal of Biomaterials Applications
Thanh Dinh Nguyen, Gaoke Feng, Xin Yi, Yongnan Lyu, Zhiyuan Lan, Jinggang Xia, Tim Wu, Xuejun Jiang
Objective Using coronary angiography and intravascular ultrasound methods to evaluate the performance of the novel fully bioabsorbable scaffold (NFBS) composed of poly-L-lactic acid/amorphous calcium phosphate (PLLA/ACP) at six-month follow-up by comparing with PLLA scaffolds Methods Twelve PLLA/ACP scaffolds and 12 PLLA scaffolds were implanted into the coronary arteries of 12 miniature pigs. Quantitative coronary angiography (QCA) was used to measure the reference vessel diameter (RVD), mean lumen diameter (MLD) and late lumen loss (LLL)...
August 2018: Journal of Biomaterials Applications
Garima Tripathi, Yuki Sugiura, Aivaras Kareiva, Edita Garskaite, Kanji Tsuru, Kunio Ishikawa
Although sintered β-tricalcium phosphate blocks have been used clinically as artificial bone substitutes, the crystallinity of β-tricalcium phosphate, which might dominate biocompatibility, is extremely high. The objective of this study is to evaluate the feasibility of fabricating low-crystallinity β-tricalcium phosphate blocks, which are expected to exhibit good biocompatibility via a dissolution-precipitation reaction of α-tricalcium phosphate blocks as a precursor under hydrothermal conditions at 200°C for 24 h...
August 2018: Journal of Biomaterials Applications
Lukas Raddatz, Marline Kirsch, Dominik Geier, Jörn Schaeske, Kevin Acreman, Rafael Gentsch, Scott Jones, Andreas Karau, Tommy Washington, Meike Stiesch, Thomas Becker, Sascha Beutel, Thomas Scheper, Antonina Lavrentieva
Biodegradable materials play a crucial role in both material and medical sciences and are frequently used as a primary commodity for implants generation. Due to their material inherent properties, they are supposed to be entirely resorbed by the patients' body after fulfilling their task as a scaffold. This makes a second intervention (e.g. for implant removal) redundant and significantly enhances a patient's post-operative life quality. At the moment, materials for resorbable and biodegradable implants (e...
August 2018: Journal of Biomaterials Applications
Sargon Barkarmo, Anna-Karin Östberg, Carina Birgitta Johansson, Sebastian Franco-Tabares, Petra Hammarström Johansson, Ulf Dahlgren, Victoria Stenport
Objective To investigate the cytokine expression profiles of blood cells exposed to polyetheretherketone and titanium-6 aluminum-4 vanadium materials in vitro. Materials and methods Coin-shaped samples composed of titanium-6 aluminum-4 vanadium, polyetheretherketone, and blasted polyetheretherketone were manufactured. The surfaces of the coins were characterized using optical interferometry, scanning electron microscopy, and contact angle measurements. Peripheral blood mononuclear cells collected from 10 blood donors were cultured for one, three, and six days in the presence or absence of the coins, and then assayed for cytokine production...
August 2018: Journal of Biomaterials Applications
Sabiniano Roman, Christopher Hillary, Brenda Narice, Anthony J Bullock, Dilly Oc Anumba, Sheila MacNeil
Preterm premature rupture of fetal membranes is a leading cause of preterm delivery. Preterm labour can compromise fetal survival, and even if a pregnancy affected by preterm premature rupture of fetal membrane continues, major complications associated with leakage of amniotic fluid and risk of infection can affect the normal development and survival of the baby. There are limited management options for preterm premature rupture of fetal membrane other than delivery of the baby if ascending infection (chorioamnionitis) is suspected...
August 2018: Journal of Biomaterials Applications
Yong-Su Kwon, Jin-Woo Park
This study investigated the osteogenic functionality of multipotent mesenchymal stem cells (MSCs) modulated by a chemically modified super-hydrophilic titanium (Ti) bone implant surface to elucidate the biological mechanism underlying the bone healing capacity of this modified Ti surface. A microstructured Ti surface incorporating bioactive ions (in this study, phosphate (P) ions) was prepared by wet chemical treatment. The results showed that the hydrothermally obtained crystalline P-incorporated Ti surface (P surface) displayed long-term super-hydrophilicity (water contact angles <5°) during a 36-week observation period...
August 2018: Journal of Biomaterials Applications
Qiannan Li, Wenjie Zhang, Guangdong Zhou, Yilin Cao, Wei Liu, Zhi-Yong Zhang
Insufficient neo-vascularization of in vivo implanted cell-seeded scaffold remains a major bottleneck for clinical translation of engineered bone formation. Demineralized bone matrix is an ideal bone scaffold for bone engineering due to its structural and biochemical components similar to those of native bone. We hypothesized that the microcarrier form of demineralized bone matrix favors ingrowth of vessels and bone regeneration upon in vivo implantation. In this study, a rat model of femoral vessel pedicle-based bone engineering was employed by filling the demineralized bone matrix scaffolds inside a silicone chamber that surrounded the vessel pedicles, and to compare the efficiency of vascularized bone regeneration between microcarrier demineralized bone matrix and block demineralized bone matrix...
August 2018: Journal of Biomaterials Applications
Seung Min Ryu, Suk Young Kim, In Hwan Song, Myun Whan Ahn, Chan Hee Lee, Jae Hui Jeon, Hyo Sae Ahn
Background In this study, the properties of the water glass (WG, sodium-silicate glass) were utilized to control the biodegradability of the beta tricalcium phosphate materials by the WG coating on the tricalcium phosphate disc surface with various coating thickness, chemistry, and heat-treatment. Methods Four types of disc specimens were prepared. A sample group A consisted of pure hydroxyapatite (HA) as a negative resorption control; a sample group B consisted of pure beta tricalcium phosphate as a positive resorption control; a sample group C consisted of beta tricalcium phosphate coated with WG as an early resorption model; and a sample group D consisted beta tricalcium phosphate coated with WG and heat-treated at 500°C as a delayed resorption model...
August 2018: Journal of Biomaterials Applications
Hongying Su, Wen Zhang, Yayun Wu, Xiaodong Han, Gang Liu, Qingming Jia, Shaoyun Shan
Stimuli-responsive hydrogels have been widely researched as carrier systems, due to their excellent biocompatibility and responsiveness to external physiologic environment factors. In this study, dextran-based nanogel with covalently conjugated doxorubicin (DOX) was developed via Schiff base formation using the inverse microemulsion technique. Since the Schiff base linkages are acid-sensitive, drug release profile of the DOX-loaded nanogel would be pH-dependent. In vitro drug release studies confirmed that DOX was released much faster under acidic condition (pH 2...
August 2018: Journal of Biomaterials Applications
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