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Journal of Biomaterials Applications

Seung Min Ryu, Myun Whan Ahn, Chul Hyun Park, Gun Woo Lee, In Hwan Song, Hyo Sae Ahn, Jooseong Kim, Sukyoung Kim
BACKGROUND: Recently, some authors introduced a water glass (WG, sodium-silicate glass; Na2 O·SiO2 ·nH2 O) coating over tricalcium phosphate (TCP) bioceramic to modulate its resorption rate and enhance the bone cell behaviors. In this study, four different types of granular samples were prepared to evaluate the ability of new bone formation in vivo using micro-computed tomography and histology. METHODS: Four types sample groups: group A (pure HA as a negative resorption control); group B (pure TCP as a positive resorption control); group C (WG-coated TCP as an early resorption model); and group D (same as group C but heat-treated at 500°C as a delayed resorption model)...
November 5, 2018: Journal of Biomaterials Applications
Baoqi Wang, Wei Ruan, Jue Liu, Taomei Zhang, Hailin Yang, Jianming Ruan
The microstructure, mechanical properties, and in vitro biocompatibility of vacuum-sintered Ti-xZr binary alloys (x = 5, 15, 25, 35, 45 wt%) were investigated. The results indicated that α and α' phase existed in Ti-xZr alloys. The hardness of the Ti-Zr alloys increased as the contents increased and ranged from 473 HV (Ti-5Zr) to 525 HV (Ti-45Zr). Increasing Zr content could lead to an increase in compressive and bending strength. Additionally, the Ti-45Zr alloy exhibited the maximum bending strength of 867...
November 5, 2018: Journal of Biomaterials Applications
Min Lai, Ziyang Jin, Mengying Yan, Jing Zhu, Xufeng Yan, Kui Xu
To design titanium (Ti)-based biomaterials with controlled drug-releasing bioactive property, TiO2 nanotubes with a diameter of approximately 110 nm was fabricated by electrochemical anodization. TiO2 nanotubes were then loaded with naringin by direct dropping and coated with chitosan layers. The surface morphologies, chemical compositions and wettability of different substrates were characterized by field emission scanning electron microscopy, atomic force microscope, X-ray photoelectron spectroscopy and contact angle measurement, respectively...
November 2, 2018: Journal of Biomaterials Applications
Wei Ren, Huizi Sha, Jing Yan, Puyuan Wu, Ju Yang, Rutian Li, Hang Zhang, Lixia Yu, Hanqing Qian, Baorui Liu
Paclitaxel is widely used as a radiosensitizer for various tumors, including esophageal cancer, but its therapeutic effect remains to be improved. In this study, we constructed a novel nano-radiosensitizer, anti-EGFR-iRGD-conjugated (iE)-PRNPs, by conjugating the recombinant protein anti-epidermal growth factor receptor (EGFR)-internalizing arginine-glycine-aspartic (iRGD) to the surface of paclitaxel-loaded red blood cell membrane nanoparticles (PRNPs). The iE-PRNPs were confirmed to possess tumor-targeting, high penetrability, and sustained release properties that free paclitaxel does not possess...
November 2, 2018: Journal of Biomaterials Applications
Natalio García-Honduvilla, Alejandro Coca, Miguel A Ortega, Cynthia Trejo, Jesús Román, Juan Peña, M Victoria Cabañas, Maria Vallet Regi, Julia Buján
In this work, we evaluate the tissue response and tolerance to a designed 3D porous scaffold composed of nanocrystalline carbonate-hydroxyapatite and agarose as a preliminary step in bone repair and regeneration. These scaffolds were subcutaneously implanted into rats, which were sacrificed at different times. CD4+, CD8+ and ED1+ cells were evaluated as measurements of inflammatory reaction and tolerance. We observed some inflammatory response early after subcutaneous implantation. The 3D interconnected porosity increased scaffold integration via the formation of granulation tissue and the generation of a fibrous capsule around the scaffold...
November 2, 2018: Journal of Biomaterials Applications
Maryam Soleimani, Shohreh Mashayekhan, Hossein Baniasadi, Ahmad Ramazani, Mohamadhasan Ansarizadeh
Peripheral nervous system in contrary to central one has the potential for regeneration, but its regrowth requires proper environmental conditions and supporting growth factors. The aim of this study is to design and fabricate a conductive polyaniline/graphene nanoparticles incorporated gelatin nanofibrous scaffolds suitable for peripheral nervous system regeneration. The scaffolds were fabricated with electrospinning and the fabrication process was designed with Design-Expert software via response surface methodology...
November 2, 2018: Journal of Biomaterials Applications
Eddy, Akira Tsuchiya, Kanji Tsuru, Kunio Ishikawa
Bridging beta-tricalcium phosphate (β-TCP) granules with dicalcium phosphate dihydrate (DCPD) creates a porous, interconnected β-TCP granular cement (GC) that is useful for reconstructing bone defects: the interconnected pores can accelerate new bone ingrowth and the set cement prevents the loss of granules from the bone defect area. However, the setting time of β-TCP GC in an acidic calcium phosphate solution is too short (<1 min) for handling in clinical applications, such as in orthopedic surgery...
October 30, 2018: Journal of Biomaterials Applications
Yawei Gu, Lei Zhang, Xiaoyu Du, Ziwen Fan, Long Wang, Weiyan Sun, Yu Cheng, Yufang Zhu, Chang Chen
Gelatin methacryloyl is a promising material in tissue engineering and has been widely studied in three-dimensional bioprinting. Although gelatin methacryloyl possesses excellent biocompatibility and tunable mechanical properties, its poor printability/processability has hindered its further applications. In this study, we report a reversible physical crosslinking strategy for precise deposition of human chondrocyte-laden gelatin methacryloyl bioink at low concentration without any sacrificial material by using extrusive three-dimensional bioprinting...
October 25, 2018: Journal of Biomaterials Applications
Ivana Postic, Heather Sheardown
Poly(ethylene glycol) is a polymer that is widely used as a biomaterial and has been approved in a host of applications. While generally viewed as inert, recent studies with poly(ethylene glycol) suggest that it may have some effects on cells and tissues, making it potentially attractive as a therapeutic agent. In this study, the effect of poly(ethylene glycol) on the cell viability, membrane transport and apoptotic markers of metastatic melanoma cells was examined. The data were combined with observed effects of the polymer on the cell media, including osmolality and viscosity, in order to elucidate any structure-function relationship between the polymer and cells...
October 25, 2018: Journal of Biomaterials Applications
Eimear B Dolan, Lenka Kovarova, Hugh O'Neill, Martin Pravda, Romana Sulakova, Ivana Scigalkova, Vladimir Velebny, Dorothee Daro, Nathalie Braun, Gerard M Cooney, Gabriella Bellavia, Stefania Straino, Brenton L Cavanagh, Aiden Flanagan, Helena M Kelly, Garry P Duffy, Bruce P Murphy
Injectable hydrogels that aim to mechanically stabilise the weakened left ventricle wall to restore cardiac function or to deliver stem cells in cardiac regenerative therapy have shown promising data. However, the clinical translation of hydrogel-based therapies has been limited due to difficulties injecting them through catheters. We have engineered a novel catheter, Advanced Materials Catheter (AMCath), that overcomes translational hurdles associated with delivering fast-gelling covalently cross-linked hyaluronic acid hydrogels to the myocardium...
October 25, 2018: Journal of Biomaterials Applications
Lin Li, Yan Du, Yi Xiong, Zhengwen Ding, Guoyu Lv, Hong Li, Tielong Liu
Gelatin, as natural macromolecular material, has been used in biomedical fields widely. In this study, various injectable gelatins A, B, and their compound AB microsphere-based gels (A-GMGs, B-GMGs and AB-GMGs) were prepared through water-in-oil emulsion method for hemostasis, and the effects of blood coagulation in vitro and surgical hemostasis (a deep liver wound model) in vivo were evaluated. Furthermore, the influences of gelatin sorts, the size of microsphere, zeta potential (ZP) and viscoelastic properties on hemostasis were also assessed...
October 18, 2018: Journal of Biomaterials Applications
Yang Lei, Yushun Xia, Yunbing Wang
Valvular heart diseases lead to over 300,000 heart valve replacements worldwide each year. Commercially available bioprosthetic heart valves (BHVs) are mostly made from porcine or bovine pericardiums which were crosslinked by glutaraldehyde (GLUT). However, valve failures can occur within 10 years due to progressive degradation and calcification. GLUT could crosslink collagen but it fails to stabilize elastin. In this current study, we developed a new BHVs preparation strategy named as "GLUT/TE/LOXL/EGCG" that utilizes exogenous tropoelastin (TE)/lysyl oxidase (LOXL) and epigallocatechin gallate (EGCG) to increase the elastin content as well as the stabilization of elastin...
October 18, 2018: Journal of Biomaterials Applications
Aylin M Deliormanlı, Mert Türk, Harika Atmaca
In the study, three-dimensional, grid-like silicate-based bioactive glass scaffolds were manufactured using a robotic deposition technique. Inks were prepared by mixing 13-93 bioactive glass particles in Pluronic® F-127 solution. After deposition, scaffolds were dried at room temperature and sintered at 690°C for 1 h. The surface of the sintered scaffolds was coated with graphene nanopowder (1, 3, 5, 10 wt%) containing poly(ε-caprolactone) solution. The in vitro mineralization ability of the prepared composite scaffolds was investigated in simulated body fluid...
September 24, 2018: Journal of Biomaterials Applications
Qiang Fu, Huaijuan Ren, Chen Zheng, Chao Zhuang, Tong Wu, Jinyan Qin, Zejian Wang, Yantian Chen, Nianmin Qi
Dental pulp stem cell is a new type of mesenchymal stem cell that has a potential for tissue regeneration. Gelatin sponges are often used for hemostasis in dental surgery. In this study, we aimed to evaluate the dental pulp stem cells' proliferation and osteogenic differentiation in different layer-by-layer-modified gelatin sponge scaffolds including the G, G + P (gelatin sponge+ poly-l-lysine modification), G + M (gelatin sponge + mineralization modification), and G + M + P (gelatin sponge + mineralization modification + poly-l-lysine modification) groups in vitro and assessed them in vivo...
September 14, 2018: Journal of Biomaterials Applications
Sahar Balagholi, Mozhgan Rezaei Kanavi, Shaban Alizadeh, Rasul Dabbaghi, Samira Karami, Bahareh Kheiri, Narsis Daftarian
This study was conducted to examine morphological, genotypic, and phenotypic alterations occurring in cultured adult human retinal pigment epithelial cells when encapsulated with different concentrations of fibrin glue. Cultivated adult human retinal pigment epithelial cells were encapsulated with different concentrations of fibrin glue, namely FG1 (42 mg/dl), FG2 (84 mg/dl), FG3 (124 mg/dl), FG4 (210 mg/dl), followed by the evaluation of genetic and cytomorphological changes and protein expression...
September 13, 2018: Journal of Biomaterials Applications
Hosung Joe, Young Joon Seo
Biofilm formation has been implicated as a cause of post-tympanostomy tube otorrhea in patients suffering from otitis media with effusion, and biofilms have been found to adhere to all available types of tympanostomy tubes (TT) made from silicone. In this study, we present a novel stent designed with a reduced surface area and a titanium dioxide (TiO2 ) coating to prevent biofilm formation. Using a radio frequency power supply, tympanostomy stents (TS) made from Nitinol (Nikel-titanium) were coated with TiO2 to form an oxide layer on the metallic target...
October 2018: Journal of Biomaterials Applications
Devika M Varma, Michelle S DiNicolas, Steven B Nicoll
Low back pain is a major cause for disability and is closely linked to intervertebral disc degeneration. Mechanical and biological dysfunction of the nucleus pulposus in the disc has been found to initiate intradiscal degenerative processes. Replacing or enriching the diseased nucleus pulposus with an injectable, stem cell-laden biomaterial that mimics its material properties can provide a minimally invasive strategy for biological and structural repair of the tissue. In this study, injectable, in situ-gelling carboxymethylcellulose hydrogels were developed for nucleus pulposus tissue engineering using encapsulated human marrow-derived mesenchymal stromal cells (hMSCs)...
October 2018: Journal of Biomaterials Applications
Yan-Pin Fan, Jian-Feng Lu, An-Tian Xu, Fu-Ming He
Bovine origin matrix has been widely used in clinical applications and investigated by various research institutions. However, the potential factors that influence bone regeneration are still not thoroughly understood and need further investigations. In this study, bone regeneration properties of anorganic bovine bone matrix (ABBM), organic-containing bovine bone matrix (OBBM), and widely acknowledged anorganic bovine bone matrix (Bio-Oss) were compared. Besides, the correlations between physiochemical characterizations and bone regeneration properties of the three xenografts were also investigated...
October 2018: Journal of Biomaterials Applications
Nicole Edwards, Denis Feliers, Qingwei Zhao, Randolph Stone, Robert Christy, Xingguo Cheng
Chronic wounds complicated by diabetes are a significant clinical issue, and their occurrence is expected to continue to rise due to an increased prevalence of diabetes mellitus, especially type 2 diabetes. Diabetic wounds frequently lead to nonhealing ulcers, and often eventually result in limb amputation due to the high risk of infection of the chronic wound. Here, we present a tissue-engineered treatment that combines a novel electrochemically deposited collagen wound matrix and human adipose-derived stem cells...
October 2018: Journal of Biomaterials Applications
Hossein Semyari, Majid Salehi, Ferial Taleghani, Arian Ehterami, Farshid Bastami, Toktam Jalayer, Hadis Semyari, Mir Hamed Nabavi, Hassan Semyari
In this study, hydroxyapatite nanoparticles containing 10% doxycycline, a structural isomer of tetracycline, was prepared by the co-precipitation method. It was added to collagen solution for the preparation of the scaffold with freeze-casting method in order to develop a composite scaffold with both antibacterial and osteoinductive properties for repairing bone defects. The scaffolds were evaluated regarding their morphology, porosity, degradation and cellular response. The scaffolds for further investigation were added in a rat calvaria defect model...
October 2018: Journal of Biomaterials Applications
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