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Journal of Biomaterials Applications

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January 15, 2019: Journal of Biomaterials Applications
Yu Hu, Ziying Li, Wei Shi, Yanxue Yin, Heng Mei, Huafang Wang, Tao Guo, Jun Deng, Han Yan, Xuan Lu
Cerebral thrombosis disease is a worldwide problem, with high rates of morbidity, disability, and mortality. Magnetic resonance imaging diffusion-weighted imaging was used as an important early diagnostic method for cerebral thrombotic diseases; however, its diagnosis time is 2 h after onset. In this study, we designed EGFP-EGF1-NP-Fe3 O4 for earlier diagnosis of cerebral thrombosis by taking advantage of EGFP-EGF1 fusion protein, in which EGF1 can bind with tissue factor and enhanced green fluorescent protein has previously been widely used as a fluorescent protein marker...
January 15, 2019: Journal of Biomaterials Applications
Kentaro Hozumi, Yui Teranishi, Sayaka Enomoto, Fumihiko Katagiri, Yamato Kikkawa, Motoyoshi Nomizu
Extracellular matrix molecules are recognized by several integrin subtypes, making identification of cross-talk among different integrin subtypes difficult. Here, we evaluated the cross-talk of integrin subtypes using four different integrin-binding peptides (FIB1; integrin αvβ3/α5β1, A2G10; integrin α6β1, EF1zz; integrin α2β1, or 531; integrin α3β1) derived from extracellular matrix molecules. Various combinations of two different integrin-binding peptides were mixed and conjugated on a chitosan matrix at various molar ratios and were evaluated for cell attachment activity...
January 12, 2019: Journal of Biomaterials Applications
Srikumar Krishnamoorthy, Zhengyi Zhang, Changxue Xu
Hydrogels have been widely used as extracellular matrix materials in various three-dimensional bioprinting applications. However, they possess limitations such as insufficient mechanical integrity and strength, especially in the vascular applications requiring suture retention and tolerance of systemic intraluminal pressure. Interpenetrating network hydrogels are unique mixtures of two separate hydrogels with enhanced properties. This paper has demonstrated the fabrication of three-dimensional cellular constructs based on gelatin methacrylate-alginate interpenetrating network hydrogels using a microgel-assisted bioprinting method...
January 12, 2019: Journal of Biomaterials Applications
Xiangshun Li, Huijing Zhao
Small-diameter vascular grafts may fail after implantation due to various reasons from mechanical and biological aspects. In order to evaluate the mechanical durability of small-diameter vascular grafts after implantation, an artificial vascular biomimetic environment that can simulate body temperature, the liquid environment outside the vessel, and continuous blood flow and pulsatile pressure was constructed. This device can be used as a "pre-test" prior to animal experiments to explore the changes of mechanical and degradation properties in the long-term in vivo environment...
January 12, 2019: Journal of Biomaterials Applications
Subhadip Basu, Aritri Ghosh, Ananya Barui, Bikramjit Basu
In the perspective of dental restorative applications, co-doped bioceramics have not been explored much. From the clinical perspective, a successful dental implant is expected to interact with peri-prosthetic bones, gingival tissue, and surrounding connective tissues. The interaction of implant and implant coating materials with bone tissue is well studied. However, their interaction with surrounding epithelial components needs scientific validation. In this context, the present study aims at quantitative evaluation of the electrical properties of Fe/Sr co-doped biphasic calcium phosphate (BCP) samples and assessment of their cytocompatibility with epithelial (vero) cells...
January 10, 2019: Journal of Biomaterials Applications
Ning Meng, Yan Gong, Jiefeng Zhang, Xin Mu, Zhimei Song, Runliang Feng, Hua Zhang
Although curcumin possesses anti-atherogenic and anti-inflammatory properties, its application is limited because of its low aqueous solubility and poor oral bioavailability. Recently, our group synthesized a novel linear-dendrimer methoxy-poly (ethylene glycol)-b-poly(ε-caprolactone) copolymer nanoparticle loading curcumin (Cur-NPs) which could improve solubility and release property of curcumin. In the present study, we further evaluated its anti-atherosclerotic effect in apolipoprotein E-/- mice. Our results demonstrated that the Cur-NPs significantly decreased atherosclerotic lesion areas and were more effective in stabilizing vulnerable plaques compared with free curcumin...
December 12, 2018: Journal of Biomaterials Applications
Eun-Ho Song, Yun-Jeong Seong, Cheonil Park, In-Gu Kang, Hyoun-Ee Kim, Seol-Ha Jeong
Thiolated biodegradable polyurethane (TG-DPU) was synthesized using a one-pot reaction with thioglycerol adopted as a functionalized chain extender. After characterization of the chemical structure of TG-DPU using proton nuclear magnetic resonance spectroscopy, bone morphogenetic protein (BMP-2) was loaded in the TG-DPU under oxidative conditions to form disulfides between the free thiol of TG-DPU and BMP-2. The interaction between TG-DPU and BMP-2, so-called bioconjugates, was investigated using X-ray photoelectron spectroscopy analysis; the appearance of disulfide (S-S) linkage indicated the formation of a polymer/growth factor conjugate system...
December 11, 2018: Journal of Biomaterials Applications
Aarón de Jesus Palacios-Rodríguez, Mauricio Flores-Moreno, Laura Edith Castellano, Ramón Carriles, Iraís Quintero-Ortega, Mario Murguía-Pérez, Guillermo Cruz, Juan Vargas-Mancilla, Arturo Vega-González, Birzabith Mendoza-Novelo
The stability and bioactivity of biologic implants rely mainly on the control of the crosslinking process of collagen. However, the most common methods have no control on the crosslinking degree producing it excessively. This study outlines the role of crosslinking of collagen-based implants with oligourethane on the host response following reconstruction of a rat full-thickness abdominal wall defect. We decellularized and crosslinked bovine pericardial tissue to achieve two crosslinking degrees. For the decellularized implants, named as non-crosslinked (N-CL), the collagen-amines were 0...
December 10, 2018: Journal of Biomaterials Applications
Toni Matson, Jonathan Gootee, Colten Snider, John Brockman, David Grant, Sheila A Grant
Soy lecithin has been shown to play a critical role in cell signaling and cellular membrane structure. In addition, it has been shown to increase biocompatibility, hydrophilicity, and decrease cytotoxicity. Gold nanoparticles have also shown to improve cellularity. Lecithin, gold nanoparticles, and polycaprolactone (PCL) solutions were electrospun in order to develop unique mesh materials for the treatment of osteoarthritis. The electrospinning parameters were optimized to achieve different solution ratios for fiber optimization...
December 6, 2018: Journal of Biomaterials Applications
Saba Zahid, Abdul Samad Khan, Aqif Anwar Chaudhry, Sarah Ghafoor, Qurat Ul Ain, Ahtasham Raza, Muhammad Imran Rahim, Oliver Goerke, Ihtesham Ur Rehman, Asma Tufail
Development of a guided occlusive biodegradable membrane with controlled morphology in order to restrict the ingrowth of epithelial cells is still a challenge in dental tissue engineering. A bilayer membrane with a non-porous upper layer (polyurethane) and porous lower layer (polycaprolactone and bioactive glass composite) with thermoelastic properties to sustain surgery treatment was developed by lyophilization. Morphology, porosity, and layers attachment were controlled by using the multi-solvent system. In vitro and in vivo biocompatibility, cell attachment, and cell proliferation were analyzed by immunohistochemistry and histology...
December 3, 2018: Journal of Biomaterials Applications
Gangquan Chen, Yaling Wu, Dongping Yu, Rubing Li, Wenyuan Luo, Guifu Ma, Chao Zhang
Poor blood circulation makes it difficult for antitubercular drugs to achieve effective bactericidal concentration at tuberculose focus. The residual Mycobacterium tuberculosis around surgical wound would multiply, resulting in nonunion or sinus formation. Carbon nanotubes have strong tissue penetration and can cross many kinds of physiological barriers. Here, we constructed a chitosan/carbon nanotubes nanoparticles to control slow release of isoniazid. Transmission electron microscopy and nanoparticle tracking and analysis results showed that the diameter of chitosan/carbon nanotubes nanoparticles was between 150 and 250 nm...
December 3, 2018: Journal of Biomaterials Applications
Gang Li, Shuhao Qin, Xiaonan Liu, Daohai Zhang, Min He
Biodegradable polymers, because their degradation products are small molecules that do not cause immune system rejection, have been increasingly used by researchers to explore the preparation of scaffold with excellent mechanical properties, biocompatibility and biodegradability. In this study, nano-hydroxyapatite and polybutylene succinate were mixed by solution-blending to prepare a porous scaffold that could be used in the biomedical industry. Based on the viewpoint of bionics, porous scaffold with well pore structure and uniform dispersion of nano-hydroxyapatite particles was prepared using ethanol as a porogen...
November 27, 2018: Journal of Biomaterials Applications
Atul A Chaudhari, Sameer Joshi, Komal Vig, Rajnish Sahu, Saurabh Dixit, Rade Baganizi, Vida A Dennis, Shree R Singh, Shreekumar Pillai
OBJECTIVE: To investigate the toxicity and antibacterial application of antimicrobial peptide-functionalized silver-coated carbon nanotubes against Staphylococcus infection using a full thickness human three-dimensional skin model. MATERIALS AND METHODS: The three-dimensional skin formation on the scaffolds was characterized by electron microscopy and investigation of several skin cell markers by real time-reverse transcriptase polymerase chain reaction. Functionalized silver-coated carbon nanotubes were prepared using carboxylated silver-coated carbon nanotubes with antimicrobial peptides such as TP359, TP226 and TP557...
November 24, 2018: Journal of Biomaterials Applications
Xiaoman Han, Guihua Meng, Qian Wang, Lin Cui, Hao Wang, Jianning Wu, Zhiyong Liu, Xuhong Guo
All kinds of commercially available wound dressings are clinically used as fleshly obstacles and therapeutic materials in opposition to microbial incursion. Few researches focused on effective-bleeding and anti-bacteria at the same time. In order to better solve this problem, two hydrogels were synthetized in this study. One is phosphate buffer solution-activated dopamine-modified-γ-poly glutamic acid (PBS-PD) hydrogel, the other one is cirsium setosum extracts-activated dopamine-modified-γ-poly glutamic acid (CSE-PD) hydrogel...
November 22, 2018: Journal of Biomaterials Applications
Reza Moonesi Rad, Engin Pazarçeviren, Elif Ece Akgün, Zafer Evis, Dilek Keskin, Sıla Şahin, Ayşen Tezcaner
Every year, many dental restoration methods are carried out in the world and most of them do not succeed. High cost of these restorations and rejection possibility of the implants are main drawbacks. For this reason, a regenerative approach for repairing the damaged dentin-pulp complex or generating a new tissue is needed. In this study, the potential of three-dimensional cellulose acetate/oxidized pullulan/gelatin-based dentin-like constructs containing 10 or 20% bioactive glass nanoparticles was studied to explore their potential for dentin regeneration...
November 20, 2018: Journal of Biomaterials Applications
Ahmad Safwan Ahmad Latfi, Sumit Pramanik, Chi Tat Poon, Ahmad Mohammed Gumel, Khin Wee Lai, Mohamad Suffian Mohamad Annuar, Belinda Pingguan-Murphy
Natural biopolymers have many attractive medical applications; however, complications due to fibrosis caused a reduction in diffusion and dispersal of nutrients and waste products. Consequently, severe immunocompatibility problems and poor mechanical and degradation properties in synthetic polymers ensue. Hence, the present study investigates a novel hydrogel material synthesized from caprolactone, ethylene glycol, ethylenediamine, polyethylene glycol, ammonium persulfate, and tetramethylethylenediamine via chemo-enzymatic route...
November 20, 2018: Journal of Biomaterials Applications
Alisa Palaveniene, Sedef Tamburaci, Ceren Kimna, Kristina Glambaite, Odeta Baniukaitiene, Funda Tihminlioğlu, Jolanta Liesiene
Recently, usage of marine-derived materials in biomedical field has come into prominence due to their promising characteristics such as biocompatibility, low immunogenicity and wide accessibility. Among these marine sources, cuttlebone has been used as a valuable component with its trace elemental composition in traditional medicine. Recent studies have focused on the use of cuttlebone as a bioactive agent for tissue engineering applications. In this study, hydroxyapatite particles were obtained by hydrothermal synthesis of cuttlebone and incorporated to cellulose scaffolds to fabricate an osteoconductive composite scaffold for bone regeneration...
November 19, 2018: Journal of Biomaterials Applications
Wenlan Qiao, Lu Lu, Guangxue Wu, Xianglian An, Dong Li, Jing Guo
Since synthetic nerve conduits do not exhibit ideal regeneration characteristics, they are generally inadequate substitutes for autologous nerve grafts in the repair of long peripheral nerve defects. To resolve this problem, in this study, a nerve regeneration acellular nerve graft (ANG) with homologous dental pulp stem cells (DPSCs) was constructed. Xenogeneic ANG was processed by Myroilysin to completely remove cells and myelin sheath, while preserving extracellular matrix (ECM) microstructure of the natural nerve...
November 17, 2018: Journal of Biomaterials Applications
Jingwen Wu, Guohou Miao, Zhichao Zheng, Zhengmao Li, Wen Ren, Caijuan Wu, Yuanjing Li, Zhu Huang, Lan Yang, Lvhua Guo
Drug delivery and release are a major challenge fabricating bone tissue engineering. In this study, we fabricated new sustained release hydrogel scaffolds composited of mesoporous bioactive glass, sodium alginate and gelatin by a three-dimensional printing technique. Naringin and calcitonin gene-related peptide were used as drugs to prepare drug-loaded scaffolds by direct printing or surface absorption. The physicochemical properties of the scaffolds and the drug release profiles of the two drug-loading models were investigated...
November 14, 2018: Journal of Biomaterials Applications
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