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Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy

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https://www.readbyqxmd.com/read/11608133/-not-available
#1
J Benedum
No abstract text is available yet for this article.
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693271/-preliminary-results-of-the-2nd-multicenter-study-thrombocytapheresis-with-the-fresenius-as-104-blood-cell-separator-and-ring-study-of-cell-counting-section-of-therapeutic-and-preparative-hemapheresis-of-the-dgti
#2
MULTICENTER STUDY
N Müller, V Kretschmer, H J Neumann, T Weisswange
Only multicenter studies on cell separators give valid data to compare different cell separators. The aim of the 2nd multicenter study was to evaluate the separation protocol, software version V 4.61, of the Fresenius AS-104 cell separator for efficiency and deviation from predicted yields. Plateletpheresis data from twelve hemapheresis centers, using identical apheresis protocols and cell counting methods, were registered and statistically analyzed. Additionally, the counting methods of the centers were controlled by a ring study with biweekly external cell count trials...
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693270/-thrombocyte-substitution-in-hematologic-patients
#3
M Wiesneth
Worldwide, platelet transfusions have increased substantially, especially in hematological patients. The prophylactic and therapeutic indications for platelet substitution as well as the choice of platelet preparation are discussed for patients with acute leukemia or aplastic anemia who need the highest platelet support. Here we present our current strategy, i.e., prophylactic transfusions with random platelets in acute leukemia and therapeutic transfusions with filtered random platelets in aplastic anemia patients only...
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693269/-substitution-of-thrombocyte-concentrates-in-polytransfused-patients
#4
REVIEW
W Mempel, M Böck
The routine use of platelet concentrates has greatly increased during the last years. Most of the concentrates are transfused to hematologic patients, who frequently receive additional red blood cells. These polytransfusion regimens often result in the formation of HLA- or platelet-specific antibodies, which lead to refractoriness to further platelet support. In order to avoid this problem, the number of HLA antigens transmitted should be reduced. Therefore, a consequent leukocyte depletion of all blood products administered to multitransfused patients seems to be necessary...
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693268/-indications-for-fresh-frozen-plasma-evaluation-of-virus-inactivating-preparations
#5
REVIEW
G Pindur, H Kiesewetter, U T Seyfert, E Wenzel
When no specific factor concentrate is available fresh-frozen plasma (FFP) is indicated in the treatment of clinically relevant hemorrhagic diathesis. These disorders include congenital factor V and XI deficiencies, multiple factor defects, as disseminated intravascular coagulation and severe liver disease, and patients receiving massive transfusions, when bleeding occurs and severe abnormalities on coagulation testing are evident. FFP is beneficial when used with plasma exchange in thrombotic thrombocytopenic purpura and related disorders...
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693267/-indications-for-irradiated-blood-components-dose-and-side-effects
#6
REVIEW
T H Eiermann
Transfusion-associated graft versus host disease (ta-GvHD) is a rare but almost lethal complication of blood transfusion in immunocompromised patients. To prevent ta-GvHD, irradiated blood products should be given to patients at risk: patients after bone marrow transplantation, newborns and children in the 1st year, patients with severe combined immunodeficiency, and patients receiving blood from first-degree relatives. Blood products should be irradiated at least with 30 Gy just before transfusion. With this regime in practice for 4 years, no complications and side effects were seen...
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693266/-washing-and-filtration-of-blood-components-which-indications-are-established
#7
REVIEW
J Neppert
The washing of cells in blood components for transfusion is necessary (1) in cases of severe incompatibility to constituents of plasma in these components and (2) in cases of maternal antibodies to blood cells of the child when the child needs maternal blood components, e.g. in many cases of neonatal alloimmune thrombocytopenia. A single washing step is recommended in certain cases: paroxysmal nocturnal hemoglobinuria and T activation of red blood cells. There is no indication that components should be washed in cases of autoimmune hemolytic anemia...
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693265/transfusion-induced-immunosuppression-and-perioperative-infections
#8
REVIEW
P I Tartter
No abstract text is available yet for this article.
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693264/-hiv-prevalence-and-hiv-incidence-in-blood-donors-in-baden-w%C3%A3-rttemberg
#9
C Maurer, W Kiehl, D Altmann
Since several years the frequency of HIV infections among screened blood donors in Baden-Württemberg (a state in southwest Germany) shows no remarkable differences between the German Red Cross donors and the donors of other blood banks. The authors advocate the hypothesis that different HIV rates among donors depend on their social environment. The number of HIV infections expected increases with the size of the donors' places of residence. The donor populations of different blood banks of Baden-Württemberg seem to be equal...
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693263/-risk-of-immunization-to-blood-cells-and-diagnostic-and-therapeutic-implications
#10
REVIEW
V Kiefel
Transfusion of blood and blood components may be fraught with serious immunologically mediated side effects. Acute hemolytic reactions are still the most common cause of fatal transfusion sequelae. The incidence of alloimmunization against erythrocyte antigens as studied in long-term transfused patients with thalassemia depends on the age at the beginning of transfusion therapy. HLA alloimmunization is often associated with refractoriness to platelet transfusions and febrile transfusion reactions. Neonatal alloimmune thrombocytopenia and post-transfusion purpura are elicited by platelet-specific antibodies reacting with determinants on platelet glycoproteins IIb/IIIa, Ib/IX, and Ia/IIa...
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693262/-production-of-factor-viii-by-genetic-techniques
#11
O Neutzling
The human factor VIII gene and the human von Willebrand factor gene have been isolated, and were transfected into a mammalian cell line (Chinese Hamster Ovary Cells = CHO Cells). The resulting factor VIII producing cell line was thoroughly characterized. No differences were found in the recombinant factor VIII compared to plasma-derived factor VIII. For factor VIII production the cells are grown in serum-free defined medium, the recombinant factor VIII is purified by immunoaffinity chromatography plus two subsequent ion exchange steps...
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693261/-recombinant-plasma-proteins-for-therapeutic-use-status-and-developmental-trends
#12
REVIEW
H Storch
The enormous progress made in biotechnology and purification of plasma proteins (pp) and the demands to avoid risks of transmitting HIV, hepatitis and other virus infections by these have resulted in the development of numerous recombinant human (rh) pp, which are now about to be used as replacement therapy in transfusion medicine. Human rh albumin has been used in clinical trials last year, a competition to serum albumin can be expected in the next time. During the last decade, the genes or cDNA have been cloned and characterized for all relevant pp involved in blood coagulation...
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693260/-optimizing-parameters-in-photodynamic-virus-inactivation-of-fresh-frozen-plasma
#13
H Mohr, B Lambrecht, H Schmitt
Fresh plasma from single-blood donations is virus-inactivated by illuminating the plasma units in their respective plastic bags with visible light for 1 h in the presence of 1 microM of the photoactive dye methylene blue. For "soft" viruses, e.g. the togavirus Semliki Forest, 0.3 microM are sufficient to achieve complete inactivation within 5-10 min. The infectious titer is reduced by 5-6 log 10 steps. To achieve the same degree of reduction in infectivity for more resistant viruses, e.g. vesicular stomatitis virus or SV 40, the virus-containing plasma at a dye concentration of 1 microM has to be light-treated for 30-45 min...
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693259/-current-status-of-isbt-standardization
#14
C Gabriel
No abstract text is available yet for this article.
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693258/-walkaway-systems-in-general-practice-behring-elisa-processor-iii
#15
G Lanzer, J Beyer, D Weisshaar
The evaluation of a new Walkaway instrument (Behring Elisa Processor III) for testing HBsAG, anti-HCV and anti-HIV 1/2 in three blood transfusion services with different sample volumes (from 60,000 to 450,000/year) gave the following results: the instrument fulfills the promises of being a real Walkaway system under routine conditions, saving labor and gaining security. The instrument must work in agreement with GLP rules, and all test steps are documented. The organization of the laboratory becomes more transparent and less flexible...
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693257/-experiences-with-the-es-600-equipment
#16
D Weisshaar
We report on the adaptation of a 'Walkaway' instrument (ES 600, Boehringer Mannheim) to be used in a blood transfusion service for donor screening of HBsAG and anti-HIV 1 + 2. Anti-CMV is obtainable, and anti-HCV will be available in the near future. Sample processing is done by a Tecan 8051 ID from barcoded primary tubes into ES 600 carousels. The capacity of this instrument is limited to 150 specimens and 600 tests per run. After mounting of reagents and control specimens, the tests are performed fully automatically without a technician...
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693256/virus-safety-of-pooled-fresh-frozen-plasma-inactivated-by-solvent-detergent-treatment
#17
A M Prince, B Horowitz
No abstract text is available yet for this article.
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693255/-autologous-blood-transfusion-as-whole-blood-or-blood-components
#18
V Kretschmer, M Weippert-Kretschmer
Modern haemotherapy is equivalent to restrictive use of blood components. Therefore, transfusion of whole blood in homologous transfusion generally cannot be accepted. In autologous blood transfusion blood components also are preferable if they can be separated appropriately. In order to have broad application of preoperative autologous blood deposits, close cooperation to transfusion services should be established guaranteeing optimal production of blood components. If this cooperation is impossible there are no objections against the use of autologous whole blood as long as the expected blood consumption is less than 3 red cell units...
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693254/-quality-assurance-in-autologous-blood-collection-from-critically-ill-patients
#19
H Kiesewetter, F Jung, J Koscielny, G Pindur, E Wenzel
Quality controls of autologous blood collections in critically ill patients comprise the control of blood products, blood collection, and of the patients themselves. The control of products is defined in European guidelines, the AMG (law governing the manufacture and prescription of medicine) and GMP regulations. The products are described in the monograph of the Federal Health Office. The quality control of blood collection in patients with a critical vascular disease is important since vagotonic or hypertensive crises may occur frequently (in 10-15% of cardiosurgical patients)...
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
https://www.readbyqxmd.com/read/7693253/-quality-assurance-in-preoperative-autologous-blood-collection-from-the-viewpoint-of-the-anesthetist
#20
REVIEW
G Singbartl, W Schleinzer
From the anesthetist's point of view the following safety measures regarding autologous blood donation have to be considered: [1] inclusion/exclusion criteria for the patient's selection; [2] quality control of the autologous product itself and [3] adequate technical standards of the equipment applied. There is no doubt, the criteria used for the patient's selection of an autologous predeposit program have a great impact both on the number and the severity of complications that might occur. Anesthetists consider a patient eligible for an autologous predeposit program if he/she is considered eligible for an elective operative procedure, too; since this means that this patient demonstrates compensated organ functions (e...
1993: Beiträge Zur Infusionstherapie, Contributions to Infusion Therapy
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