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Journal of Human Hypertension

Gennaro Russo, Ilaria Liguori, Luisa Aran, Giulia Bulli, Francesco Curcio, Gianluigi Galizia, Gaetano Gargiulo, Gianluca Testa, Andrea Ungar, Francesco Cacciatore, Domenico Bonaduce, Pasquale Abete
In the last years, guidelines for the treatment of hypertension recommended individualized blood pressure goals for geriatric population because of elderly susceptibility to adverse outcomes and higher mortality rate deriving from the excessive blood pressure lowering, especially in "frail" elderly. Recent findings from the SPRINT study, which demonstrated that intensive blood pressure lowering was associated with lower rates of cardiovascular events and mortality in both hypertensive fit and frail elderly subjects compared to standard treatment, heavily influenced the recent US guidelines...
July 10, 2018: Journal of Human Hypertension
Andreas Rosenblad
High systolic blood pressure (SBP) is often used as a measure of hypertension in epidemiological studies. Alternative blood pressure (BP) indices include diastolic blood pressure (DBP), pulse pressure (PP), mid-blood pressure (MBP) and mean arterial pressure (MAP). The present study compares the predictive ability for all-cause mortality (ACM) of these indices and the novel BP index mean proportional arterial pressure (MPAP), defined as the weighted mean of SBP and DBP where the weights are proportional to SBP's and DBP's contributions to the sum of SBP and DBP...
July 10, 2018: Journal of Human Hypertension
Ya-Jing Pan, Lian He, Si-Jia Zhou, Li-Jie Zhang, Ai-Hua Zhang, Yang-Yu Zhao
The aims of this study are to explore the correlation between the expressions of urotensin II (UII) and autophagic markers (LC3 and P62) in patients with severe preeclampsia (SPE). A total of 64 pregnant subjects were recruited, including 29 healthy pregnancies and 35 preeclamptic patients (7 mild preeclamptic (MPE) patients and 28 SPE patients). UII and autophagic markers expression in placenta specimens was investigated by immunohistochemistry (IHC), RT-qPCR, and western blot. IHC analysis manifested that the expressions of UII and autophagic markers were mainly located in the placental cytotrophoblast and syncytiotrophoblast...
July 10, 2018: Journal of Human Hypertension
Minyi Tan, Li Cai, Jun Ma, Jin Jing, Yinghua Ma, Yajun Chen
Gestational age and birth weight are supposed to associate with childhood blood pressure but remains unclear. This study aimed to investigate the association between gestational age, birth weight, and blood pressure among Chinese children. In all, 49 357 children aged 6-18 years were included from a nationwide survey in China. Gestational age, birth weight, and socioeconomic data were collected by questionnaires. Systolic (SBP) and diastolic (DBP) blood pressure were objectively measured. The associations between birth measures and blood pressure were examined by multivariable linear regression and logistic regression...
June 25, 2018: Journal of Human Hypertension
Eirini Papadopoulou, Elena Angeloudi, Spiridon Karras, Pantelis Sarafidis
The presence of hypertension in patients with diabetes mellitus (DM) substantially increases cardiovascular risk. Blood pressure (BP) decrease in these individuals is associated with large reductions in cardiovascular morbidity and mortality, but the optimal BP levels in DM still remain a matter of important controversy. For almost 20 years, guidelines recommended an office BP target of <130/80 mmHg in diabetic individuals, following evidence from trials randomizing patients to diastolic BP levels. When the action-to-control-cardiovascular-risk-in-diabetes-blood-pressure (ACCORD-BP) study showed that systolic BP (SBP) <120 mmHg was associated with similar risk to SBP < 140 mmHg in type 2 DM, all guidelines stepped back to recommend a SBP < 140 mmHg, despite the obvious limitations of ACCORD-BP, including the surprisingly low event rate and the actual average BP of 133...
June 22, 2018: Journal of Human Hypertension
Gulam Muhammed Al Kibria, Krystal Swasey, Allysha Choudhury, Vanessa Burrowes, Kristen A Stafford, S M Iftekhar Uddin, Mohammadhassan Mirbolouk, Atia Sharmeen, Angela Kc, Dipak K Mitra
We analyzed the Bangladesh Demographic and Health Survey 2011 data to examine absolute differences in hypertension prevalence according to the hypertension definition of the "2017 American College of Cardiology/American Heart Association (2017 ACC/AHA) Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults" and "Seventh Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC7)" 2003 guidelines. Among 7839 participants ≥35 years, the JNC7 and 2017 ACC/AHA classified 25...
June 13, 2018: Journal of Human Hypertension
Nur Liana Ab Majid, Mohd Azahadi Omar, Yi Yi Khoo, Balkish Mahadir Naidu, Jane Ling Miaw Yn, Wan Shakira Rodzlan Hasani, Halizah Mat Rifin, Hamizatul Akmal Abd Hamid, Tania Gayle Robert Lourdes, Muhammad Fadhli Mohd Yusoff
Hypertension is strongly associated with chronic diseases such as myocardial infarction, stroke, heart failure, and renal failure. The objective of this study is to determine the trend of prevalence, awareness, treatment, and control of hypertension among Malaysian population since 2006 to 2015. The study used the data from National Health and Morbidity Survey (NHMS) 2006, 2011, and 2015. It was a cross-sectional with two-stage stratified random sampling throughout Malaysia for eligible respondents 18 years old and above...
June 13, 2018: Journal of Human Hypertension
Prateek Sharma, Robert D Brook
High blood pressure (BP) affects over one billion people and is the leading risk factor for global mortality. While many lifestyle and genetic risk factors are well-accepted to increase BP, the role of the external environment is typically overlooked. Mounting evidence now supports that numerous environmental factors can promote an elevation in BP. Broadly speaking these include aspects of the natural environment (e.g., cold temperatures, higher altitude, and winter season), natural disasters (e.g., earthquakes, volcanic eruptions), and man-made exposures (e...
June 13, 2018: Journal of Human Hypertension
Fabio Angeli, Giorgio Gentile, Monica Trapasso, Paolo Verdecchia, Gianpaolo Reboldi
Hypertension is a key risk factor for chronic kidney disease (CKD), but can also be a detrimental consequence of established CKD. Unsurprisingly, the majority of subjects with abnormal creatinine in the general population are also hypertensive, with a huge toll on national health care systems worldwide due to a staggering increase in the risk of cardiovascular complications and end-stage renal disease requiring renal replacement therapy. In this setting, a comprehensive and careful assessment of the whole 24-h blood pressure (BP) profile could be of paramount importance in ensuring a timely diagnosis of hypertension and an optimal therapeutic control...
June 13, 2018: Journal of Human Hypertension
Xiao Cui, Quanhui Zhao, Junxing Yu, Ruiying Zhang, Wei Li, Lu Song, Chunhui Li, Hualing Zhao, Aiping Wu, Shouling Wu, Jun Cai
The association between cumulative mean arterial blood pressure (MAP) and risks of adverse cardiac and cerebrovascular events (CCVEs) has not been characterized. This prospective cohort study included 53,813 participants, free of prior myocardial infarction or stroke in or before 2010 (baseline) from a community-based cohort including 101,510 participants. Cumulative MAP was defined as the summed average MAP for each pair of consecutive examinations multiplied by the time interval with the data from previous surveys (2006- 2007, 2008 to 2009, 2010-2011)...
June 11, 2018: Journal of Human Hypertension
Yan Yang, Qi-Hong Wu, Yan Li, Ping-Jin Gao
Recent research suggested that certain small leucine-rich repeat proteoglycans (SLRPs) were involved in the development of atherosclerosis. The present study investigated the relationship between carotid atherosclerosis plaque and the circulating levels of some SLRPs, including decorin, lumican, and osteoglycin, in essential hypertension. In total, 176 essential hypertensive patients were recruited (mean age 62.1 ± 9.4, male 56.8%) in this study and were classified into two groups: patients with carotid artery plaque (n = 105, 60%) and patients without carotid artery plaque (n = 71, 40%)...
June 5, 2018: Journal of Human Hypertension
Li Ren, Min Shi, Yanan Wu, Jingxian Ni, Lingling Bai, Hongyan Lu, Jun Tu, Jinghua Wang, Xianjia Ning
We aimed to explore the impact of blood pressure (BP) levels on atherosclerosis in a rural Chinese population with a low-education level, low income, high incidence of stroke, and high prevalence of hypertension. B-mode ultrasonography was used to measure carotid intima-media thickness (CIMT) in adults aged ≥ 45 years with no history of stroke or cardiovascular disease. A total of 5403 eligible subjects were included in this study. The mean CIMT was 0.57 mm overall, 0.58 mm for men and 0.56 mm for women...
June 5, 2018: Journal of Human Hypertension
J N Liu, M Dolikun, J Štambuk, I Trbojević-Akmačić, J Zhang, H Wang, D Q Zheng, X Y Zhang, H L Peng, Z Y Zhao, D Liu, Y Sun, Q Sun, Q H Li, J X Zhang, M Sun, W J Cao, A Momčilović, G Razdorov, L J Wu, A Russell, Y X Wang, M S Song, G Lauc, W Wang
Hypertension results from the interaction of genetic and acquired factors. IgG occurs in the form of different subclasses, of which the effector functions show significant variation. The detailed differences between the glycosylation profiles of the individual IgG subclasses may be lost in a profiling method for total IgG N-glycosylation. In this study, subclass-specific IgG Fc glycosylation profile was investigated in the four northwestern Chinese minority populations, namely, Uygur (UIG), Kazak (KZK), Kirgiz (KGZ), and Tajik (TJK), composed of 274 hypertensive patients and 356 healthy controls...
June 5, 2018: Journal of Human Hypertension
M D Sekgala, K D Monyeki, A Mogale, Z J Mchiza, W Parker, S R Choma, H M Makgopa
The study aimed to investigate the association between metabolic syndrome (MetS) and lifestyle risk factors among Ellisras adults. A cross-sectional study was conducted on 624 adults (306 males and 318 females). MetS was defined according to the criteria of the International Diabetes Federation. The prevalence of MetS was 23.1% (8.6% males and 36.8 % females). Females appeared to have higher mean values for waist circumference (WC), fasting blood glucose (FBG), total cholesterol (TCHOL) and low-density lipoprotein cholesterol (LDL-C), while males had high mean values for high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), systolic blood pressure (SBP) and diastolic blood pressure (DBP)...
June 5, 2018: Journal of Human Hypertension
Ioanna Eleftheriadou, George C Drosos, Anastasios Tentolouris, Konstantonis George, Petros P Sfikakis, Athanasios D Protogerou, Nikolaos Tentolouris
The main aim of this cross-sectional study was to investigate the association between pulse pressure amplification (PPA) and cardiac autonomic activity (baroreflex sensitivity (BRS) and heart rate variability (HRV)) in patients with type 2 diabetes mellitus (T2DM). In addition, we examined the association between cardiac autonomic activity and central hemodynamic parameters that may affect PPA such as augmentation index (AIx), aortic stiffness (pulse wave velocity (PWV)), and common carotid artery stiffness distensibility coefficient (DC)...
May 23, 2018: Journal of Human Hypertension
Sara Q C Giampá, Rodrigo P Pedrosa, Carolina C Gonzaga, Adriana Bertolami, Celso Amodeo, Sofia F Furlan, Luiz A Bortolotto, Geraldo Lorenzi-Filho, Luciano F Drager
Obstructive sleep apnoea (OSA) is the main secondary form associated with resistant hypertension (RH), but it is largely underdiagnosed and consequently undertreated in clinical practice. The Berlin questionnaire (BQ) is a useful tool among general population, but seems to not perform well among patients with RH. Recently, NoSAS score was validated in a large population, however, has not been tested in the cardiovascular scenario. Thus, we aimed to compare BQ versus the NoSAS score as screening tools for OSA in RH...
May 23, 2018: Journal of Human Hypertension
Wenjun Cao, Guoqiang Hou, Chongzheng Guo, Ying Guo, Jianzhong Zheng
Hypertension (HTN) related to health-promoting behaviors (HPB) and quality of life (QOL) in older Chinese has not been clearly identified. We sought to compare the HPB and QOL of elderly adults (aged ≥60) living with HTN in China to a community normotensive control group. Using multistage stratified cluster sampling, a sample of 543 elderly people with HTN and 550 with normotension were randomly selected and asked to complete questionnaires. The Chinese version of the Health Promoting Lifestyle Profile (HPLP-IICR) and The World Health Organization Quality of life-BREF instrument (WHOQOL-BREF) were used to evaluate the HPB and QOL of elderly adults...
May 23, 2018: Journal of Human Hypertension
Xiaoyu Shu, Mei Mei, Linqiang Ma, Zhihong Wang, Shumin Yang, Jinbo Hu, Ying Song, Wenwen He, Ting Luo, Qingfeng Cheng, Yue Wang, Qianna Zhen, Qifu Li
Plasma aldosterone/renin ratio (ARR) is a useful method for primary aldosteronism (PA) screening. However some confounders, such as medications and dietary, affect plasma renin and aldosterone levels, resulting in false-negative or -positive plasma ARR. This study investigated the association between postmenopausal osteoporosis (PMO) and plasma ARR. Bone mineral density (BMD) was measured by dual-energy X-ray-absorptiometry (DXA) in 324 normotensive postmenopausal women. Based on clinical characteristics and BMD, 186 and 96 subjects were diagnosed as PMO and osteopenia respectively, and the remaining 42 subjects were grouped as normal BMD...
May 22, 2018: Journal of Human Hypertension
Yi Zhang, Dian-Zhong Zhang
The objective of this study was to examine the associations of red meat, poultry, and egg consumption with the risk of hypertension (HTN). The electronic databases of PubMed, Web of Science, and Embase were searched up to August 2017, for prospective cohort studies on the associations between red meat, poultry, or egg consumption with the risk of HTN. The pooled relative risk (RR) of HTN for the highest vs. lowest category of red meat, poultry, and egg consumption as well as their corresponding 95% confidence interval (CI) were calculated...
May 4, 2018: Journal of Human Hypertension
Ganmi Wang, Yujie Chen, Liangjin Li, Wenlu Tang, James M Wright
First-line renin-angiotensin system (RAS) inhibitors are recommended for diabetic patients because of their potential nephron-protective properties. For hypertensive patients with type 2 diabetes mellitus, little is known about first-line RAS inhibitors vs. other first-line antihypertensive agents in terms of cardiovascular outcomes. We performed a meta-analysis of randomized controlled trials (RCTs) to assess the comparative efficacy of first-line RAS inhibitors vs. other first-line antihypertensive drug classes in hypertensive patients with type 2 diabetes mellitus...
May 1, 2018: Journal of Human Hypertension
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