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Journal of Human Hypertension

Cesare Cuspidi, Carla Sala, Marijana Tadic, Elisa Gherbesi, Guido Grassi, Giuseppe Mancia
The association between pre-hypertension (pre-HTN) and subclinical carotid damage is poorly defined. We performed a meta-analysis of ultrasonographic studies assessing carotid intima-media thickness (IMT) in untreated pre-HTN subjects. The OVID-MEDLINE, PubMed, and Cochrane CENTRAL databases were searched for English-language articles without time restriction up to February 2018 through focused, high sensitive search strategies. Studies were identified by crossing the following search terms: "pre-hypertension", "high normal blood pressure", "carotid intima-media thickness", "carotid atherosclerosis", "ultrasonography"...
September 21, 2018: Journal of Human Hypertension
Wenjia Gan, Wenbin Lin, Jianjun Ouyang, Yuzhe Li, Dubo Chen, Zhenrong Yao, Pinning Feng
The aldosterone-to-renin ratio (ARR) is extensively used for primary aldosteronism detection. Chemiluminescence immune assay (CLIA) is newly applied in aldosterone and renin detection for calculating the aldosterone-to-renin ratio. The performance of new ARR in aldosteronism detection is poorly evaluated. We aim to estimate the diagnostic value of this new aldosterone-to-renin ratio by highly standardized and clinically based protocol. Four hundred and forty-two patients were enrolled in our retrospective study...
September 21, 2018: Journal of Human Hypertension
Eliza Prodel, Thales C Barbosa, Iuri Galdino, Antonio C Nobrega, Lauro C Vianna
Augmentation index (AIx), derived from aortic pulse waveform, is related to arterial stiffness and increased cardiac workload. Sex differences were observed in the relationship between blood pressure (BP) and AIx at rest. In addition, positive correlation between BP and AIx in men during a pressor stimulus was observed previously. However, whether BP is important to acute changes of AIx also in women is yet to be investigated. Therefore, we sought to investigate whether there are sex differences on the relationship between BP and AIx...
September 20, 2018: Journal of Human Hypertension
Michael Abou-Dakn, Sabine Wenzel
The present study examines the performance of the ambulatory blood pressure monitor PHYSIO-PORT UP in pregnant and preeclamptic women. The systolic blood pressure (SBP) and the diastolic blood pressure (DBP) of 33 subjects (among them 13 with preeclampsia) were sequentially measured and compared to reference measurements. Those reference measurements were taken by two observers using a mercury sphygmomanometer. Subject recruitment and evaluation of the measurement results were performed according to the European Society of Hypertension International Protocol revision 2010 (ESH-IP 2010)...
September 19, 2018: Journal of Human Hypertension
Yazmín Estela Torres-Paz, Claudia Huesca-Gómez, Fausto Sánchez-Muñoz, Rocío Martínez-Alvarado, Ma Elena Soto, Margarita Torres-Tamayo, Giovanny Fuentevilla-Álvarez, Ricardo Gamboa
miR-33a has been described as a key regulator in the initiation and progression of atherosclerosis. However, its role in arterial hypertension (HTA) has not been elucidated. Therefore, the aim of this study was to determine the association between the expression of miR-33a (5p and 3p) and the carotid intima-media thickness (cIMT) in samples of monocytes and serum from hypertensive patients. The miR-33a-5p and miR-33a-3p expression in monocytes and serum from Mexican hypertensive patients were examined by RT-PCR...
September 19, 2018: Journal of Human Hypertension
Renuka Shanmugalingam, Annemarie Hennessy, Angela Makris
Aspirin is widely used in preventing early onset preeclampsia in women who are identified as being high risk. Although the benefit of aspirin is increasingly evident and acknowledged, there remains many unanswered questions with regards to its optimal application in pregnancy. The issues mainly centre around the relatively modest risk reduction that is observed with the use of aspirin prophylactically. We aim to explore the reasons behind the conservative rate of benefit and aim to explore factors that are likely to influence the outcomes with the use of aspirin...
September 19, 2018: Journal of Human Hypertension
Eleni Georgianou, Panagiotis I Georgianos, Konstantinos Petidis, Vasilios G Athyros, Pantelis A Sarafidis, Asterios Karagiannis
Despite the proven benefits of strict blood pressure (BP) control on primary and secondary prevention of stroke, management of acute hypertensive response in the early post-stroke period is surrounded by substantial controversy. Observational studies showed that raised BP on ischemic stroke onset is prognostically associated with excess risk for early adverse events and mortality. By contrast, randomized controlled trials and recent meta-analyses showed that although antihypertensive therapy effectively controls elevated BP in the acute stage of ischemic stroke, this BP-lowering effect is not translated into improvement in the risk of death or dependency...
September 19, 2018: Journal of Human Hypertension
Durairaj Sekar
No abstract text is available yet for this article.
September 19, 2018: Journal of Human Hypertension
Monesha Gupta-Malhotra, Sanjay Shete, Michelle S Barratt, Dianna Milewicz, Syed Shahrukh Hashmi
The knowledge of epidemiology of a disease is paramount in identifying preventive measures. Currently there is a paucity of literature on the epidemiologic determinants of childhood onset essential hypertension (EH). We evaluated children with EH, ascertained in a rigorous manner, in a large multiethnic population in a tertiary pediatric hypertension clinic. We enrolled children with and without EH and obtained data by in-person interview of their parents and by direct anthropometric measurements including blood pressures...
September 17, 2018: Journal of Human Hypertension
Yu-Chen Han, Yan Tu, Le-Ting Zhou, Ming-Ming Pan, Bin Wang, Hong Liu, Ri-Ning Tang, Bi-Cheng Liu
Blood pressure (BP) management posed great challenge in hemodialysis (HD) population. We conducted a dose-response meta-analysis to investigate the quantitative features and the potential threshold effect of the associations between peridialysis BP levels and all-cause mortality risk in HD population. We searched all of the prospective cohort studies (published before 18 March 2017) on the associations between peridialysis BP levels and all-cause mortality risk. A total of 229,688 prevalent HD patients from 8 studies were included...
September 12, 2018: Journal of Human Hypertension
Wei Li, Ricong Xu, Yating Wang, Jiani Shen, Zhijian Li, Xueqing Yu, Haiping Mao
The association of body mass index (BMI) and blood pressure (BP) control and their interaction with cardiovascular (CV) mortality in continuous ambulatory peritoneal dialysis (CAPD) patients is unclear. We retrospectively analyzed a consecutive series of 1595 incident CAPD patients with hypertension from 2006 to 2013, and followed up through December 2015. The BMI was categorized according to the World Health Organization classification for Asian population. Binary logistic regression was used to assess the relationship between BMI and BP control...
September 12, 2018: Journal of Human Hypertension
Sepideh Mahboobi, Catherine Tsang, Shahla Rezaei, Sadegh Jafarnejad
The objective of this study was to systematically investigate the efficacy of oral L-citrulline supplementation on systolic and diastolic blood pressure. Studies were identified by a search of electronic databases from inception to April 2018, and combined and stratified analyses were used. Fifteen trials were identified, and data from 424 participants were included. Pooled analysis showed significant reductions in systolic blood pressure by -7.54 mmHg (95% confidence interval (CI): -9.44, -5.63; P < 0...
September 11, 2018: Journal of Human Hypertension
Chao Han, Zunsong Hu, Fangchao Liu, Xueli Yang, Tanika N Kelly, Jing Chen, Jianfeng Huang, Chung-Shiuan Chen, Jiang He, Shufeng Chen, Xigui Wu, Dongfeng Gu, Xiangfeng Lu
Genetic mechanisms involved in the susceptibility to salt sensitivity have not been completely clarified. This study aimed to comprehensively examine the association between genetic variants in the cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG/PRKG) genes and blood pressure (BP) responses to dietary sodium intervention in a Chinese population. A 7-day low-sodium intervention followed by a 7-day high-sodium intervention was conducted among 1906 Han participants from rural areas of northern China...
September 4, 2018: Journal of Human Hypertension
Ben J Smith, Alice J Owen, Danny Liew, Darren J Kelly, Christopher M Reid
This study investigated the prevalence of physical activity prescriptions in the management of high blood pressure (BP), the characteristics of people given these, and whether prescriptions were associated with the physical activity beliefs and practices of patients. A retrospective cohort study was undertaken, involving 365 general practitioners (GPs) from across Australia. The records of up to 20 patients per GP with high BP (N = 6512) were audited to identify physical activity and pharmacological prescriptions over four consecutive consultations...
September 4, 2018: Journal of Human Hypertension
Hartesh S Battu, Raj Bhopal, Charles Agyemang
Blood pressure (BP) and hypertension prevalence differences between UK South Asians (Bangladeshis, Indians and Pakistanis) and White Europeans exist in childhood and adulthood. This meta-analysis sought to quantify these differences. We searched MEDLINE (1946-2017), EMBASE (1974-2017) and GLOBAL HEALTH (1973-2017) for comparative studies and pooled the data with Revman (Cochrane Collaboration). Twenty-two studies were included-fourteen on adults and eight on children. South Asian adults had lower systolic and slightly lower diastolic BP...
September 4, 2018: Journal of Human Hypertension
Atieh Abedin Do, Emran Esmaeilzadeh, Mona Amin-Beidokhti, Reihaneh Pirjani, Milad Gholami, Reza Mirfakhraie
The multifactorial basis of preeclampsia (PE) implies that there are several genes and risk factors that are important in the development of the disease. Therefore, the exact etiology and pathogenesis of preeclampsia remains unclear. It is suggested that inappropriate regulation of the renin-angiotensin system (RAS) is a risk factor for hypertension during pregnancy. The angiotensin I-converting enzyme (ACE) serum level, a key component of the RAS, affects the blood pressure. It is hypothesized that the ACE gene polymorphisms contribute to preeclampsia development...
August 20, 2018: Journal of Human Hypertension
Yutaka Igarashi, Nobuhiko Akazawa, Seiji Maeda
The aim of the current study was to perform a systematic review and meta-analysis to evaluate the relationship between step count and changes in blood pressure (BP). Studies involving healthy adults and an intervention in the form of brisk walking with a pedometer were included. Net changes in BP and step count in each trial were calculated and pooled. In addition, the pooled net changes of two categories (trials that achieved walking 10,000 steps a day and those that did not) were compared. A meta-regression analysis was performed to examine the relationship between net changes in BP and step count...
August 20, 2018: Journal of Human Hypertension
Yu-Qing Huang, Cheng Huang, Jie Li, Bin Zhang, Ying-Qing Feng
Recently, miRNAs have emerged as new indirect markers of inflammation that are associated with adverse outcomes in cardiovascular disease. The aim of the study was to evaluate the relationship between miR29a and proteinuria in hypertension. Fifty patients with normal albuminuria, fifty patients with micro-albuminuria, and fifty patients with macro-albuminuria were enrolled. The highest levels of miR-29a and transforming growth factor-β1 (TGF-β1) were observed in the macro-albuminuria group, followed by the micro-albuminuria and the normal albuminuria groups...
August 20, 2018: Journal of Human Hypertension
Anna C Breeuwsma, Laura C Hartog, Adriaan M Kamper, Klaas H Groenier, Henk J G Bilo, Nanne Kleefstra, Kornelis J J Van Hateren
Orthostatic hypotension (OH) is defined as a drop in systolic blood pressure (SBP) of ≥20 mm Hg and/or a drop in diastolic blood pressure (DBP) of ≥10 mm Hg within 3 min of standing. The international guidelines recommend ideally diagnosing OH with a continuous blood pressure (BP) measurement device, although in daily practice interval BP measurement devices are used more often. We aimed to investigate the difference in observed prevalence of OH between an interval and a continuous BP measurement device...
August 14, 2018: Journal of Human Hypertension
Yingyi Qin, Yibin Guo, Yuanjun Tang, Cheng Wu, Xinji Zhang, Qian He, Yanfang Zhao, Jia He
The aim of our study was to investigate the effect of hypertension on health-related quality of life (HRQoL) among different age subgroups of people in Shanghai using subpopulation treatment effect pattern plot (STEPP) methodology. We utilized data from the fifth Health Service Survey of Shanghai, 2013, which utilizes a cross-sectional study design. The participants were selected into the survey by using a three-stage, stratified, random sampling method. HRQoL was evaluated by the EuroQol five-dimensional 3 level (EQ-5D-3L) questionnaire, and the EuroQol-visual analog scales (EQ-VAS) score was the main outcome...
August 6, 2018: Journal of Human Hypertension
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