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Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria

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https://www.readbyqxmd.com/read/29134985/effects-of-unripe-musa-paradisiaca-on-the-histochemistry-of-the-testis-and-testosterone-levels-in-adult-albino-rats
#1
A S Alabi, G O Omotosho, C N B Tagoe, O B Akinola, B U Enaibe
This study was aimed at determining the effects of the unripe fruit of Musa paradisiaca on the testis andtestosterone levels in male Wistar rats. The animals were grouped into three, comprising a control, and 2 treatment groupsadministered with different doses (500 mg/kg and 1000 mg/kg) daily of the fruit flour over 28 days. Histochemical evaluationof the testes was done using Haematoxylin and Eosin, Periodic acid Schiff's (PAS) and Feulgen staining techniques, whilethe serum and homogenised testicular tissue were evaluated for testosterone levels using Accu-Bind ELISA Kit...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134984/evaluation-of-neuroprotective-effect-of-hibiscus-sabdariffa-linn-aqueous-extract-against-ischaemic-reperfusion-insult-by-bilateral-common-carotid-artery-occlusion-in-adult-male-rats
#2
Olatunde Owoeye, Micheal Oluwatosin Gabriel
Ischaemic brain injury continues to be devastating, causing social, medical and relationship disruption. Oxidativedamage has been reported to be one of the mechanisms for brain damage following ischaemic stroke. The antioxidant activityof Hibiscus sabdariffa L. was investigated for a possible protective effect against ischaemia-induced brain damage in rats.Adult male Wistar rats (n=35) were divided into five groups of 7 rats per group. Group 1 served as control was given tapwater; Group 2: 500 mg/kg daily of Hibiscus sabdariffa L...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134983/anti-hyperglycaemic-effects-of-rutin-on-blood-glucose-oxidative-stress-biomarkers-and-lipid-peroxidation-in-alloxan-induced-hyperglycaemic-wistar-rats
#3
Y Tanko, A I Salisu, K A Mohammed, S A Musa, A Jimoh, R Yusuf
The present study investigated the anti-hyperglycaemic effect of rutin on blood glucose, oxidative stressbiomarkers and lipid peroxidation in alloxan induced hyperglycaemic wistar rats. Diabetes was induced in rats by anintraperitoneal (i.p) injection of alloxan monohydrate 150 mg/kg body weight. Twenty five wistar rats were divided asfollows; Group1 served as diabetic control received distilled water 2 mg/kg, Group served as positive control received 2mg/kg glibenclamide, 3, 4 and 5 received rutin at 50, 100 and 200 mg/kg body weight for 28 days respectively...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134982/electrocardiographic-and-blood-pressure-measurements-in-captive-african-lions-panthera-leo-immobilized-with-xylazine-ketamine-combination
#4
T O Omóbòwálé, P I Otuh, O A Adejumobi, J O Abiola, T Adebiyi, B N Ogunro, A O Adeogun
Electrocardiographic and blood pressure measurements are extremely valuable diagnostic tools in the evaluationof the cardiovascular system of living animals. In this study, 6-lead electrocardiograms were recorded from five male captiveAfrican lions (Panthera leo). Also, blood pressure measurements were recorded and compared from three different sites;fore limb, hind limb and the tail, were recorded. Immobilization was done with a combination of Ketamine Hydrochloride(10mg/kg) and Xylazine (3mg/kg). Measurements were recorded as mean ± standard deviation...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134981/biochemical-hormonal-and-histological-changes-in-prostate-of-wistar-rats-following-long-term-streptozotocin-induced-diabetes-mellitus
#5
Bosede Popoola, Olivia Ashefor, Olubukola Akanni, Oluwatosin Adaramoye
Diabetes mellitus (DM) is characterized by hyperglycemia and endocrine disorder. Diabetes mellitus is knownto promote male infertility by affecting sperm quality through altered steroidogenesis. The role of prostatic fluid in maintenance of sperm quality have been established. However, the effect of DM on prostate health is poorly understood.This study was designed to investigate the biochemical, hormonal and histological changes in prostate of male Wistar ratsafter 3- and 5-months DM. Twenty-six adult male Wistar rats were assigned into three groups...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134980/association-between-adiponectin-serum-lipids-and-obesity-in-a-university-setting-in-nigeria
#6
F L Ciroma, J O Ayo, A Mohammed, M B Akor-Dewu, M A Kana, S N Kase
Obesity is an energy imbalance condition, which is accompanied by metabolic and cardiovascular complications.Adiponectin, produced by adipocytes, is an important adipokine involved in carbohydrate and lipid metabolism. Adiponectinlevel is altered in obesity in various populations. In Nigeria, very few studies regarding adiponectin exist, and none, to thebest of our knowledge, investigated the relationship between adiponectin and lipid profile and obesity. Therefore, this studyaims to evaluate changes in adiponectin level and serum lipids with body mass index, and investigate the relationship betweenadiponectin, serum lipids and obesity in Nigerian adults...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134979/amlodipine-corrects-changes-in-blood-pressure-and-baroreceptor-reflex-sensitivity-in-sprague-dawley-rats-fed-a-high-salt-diet
#7
A A Adejare, O A Sofola
High dietary salt ingestion causes elevated blood pressure both in humans and in experimental animals.Following reports that Calcium Channel Blockers may exhibit differences in the response of blood vessels to pressor agents,this study sought to test the effects of amlodipine on blood pressure (BP) and baroreceptor reflex sensitivity (BRS) responsesto high salt ingestion. Three groups of weanling Sprague-Dawley rats i.e. control rats (CR), salt loaded rats (SR) and saltloaded rats concomitantly administered orally with amlodipine (SR+Am) were used...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134978/testicular-and-epididymal-histology-of-rats-chronically-administered-high-doses-of-phosphodiesterase-5-inhibitors-and-tramadol
#8
Victor U Nna, Augustine L Udefa, Emmanuel O Ofutet, Eme O Osim
Testicular oxidative stress, endocrine disruption and abnormal spermatogenesis in rats exposed to high doses ofphosphodiesterase-5 inhibitors (PDE5i) and opioids, with poor reversibility following withdrawal of treatment had beenreported. In this study, we examined the histopathological effects of high doses of sildenafil, tadalafil, tramadol andsildenafil+tramadol on the testes and epididymis of rats. Seventy male rats (180 - 200 g b.w) were assigned to one of fivegroups (n = 14), namely; A: control (0.2 mL normal saline), B: sildenafil (1 mg/100g b...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134977/metformin-effects-are-augmented-by-chronic-intermittent-cold-stress-in-high-fat-diet-fed-male-wistar-rats
#9
A O Ige, O I Iwaloye, E O Adewoye
This study investigated the effects of metformin on some glucose regulatory indices in high fat diet (HFD) fedmale Wistar rats exposed to room temperature and chronic intermittent cold stress (CICS). Thirty rats were randomly dividedinto 5 groups. Group 1(control) was maintained on standard rat chow while groups 2-5 were maintained on HFD for 8weeksrespectively prior to experimental procedures. Control, group 2(HFD untreated) and group 3(HFD+metformin (250mg/kg)were exposed to room temperature while groups 4(HFD untreated+CICS) and 5(HFD+CICS+metformin) were exposed toCICS for 21days...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134976/uptake-of-zinc-by-pteridium-aquilinum-bracken-fern-and-response-of-clarias-gariepinus-juveniles-during-chronic-and-sub-lethal-exposure
#10
F E Olaifa, A A Fabusoro
Zinc is an essential trace element but can be toxic to fish at elevated concentrations. This study was carried out to assess the uptake of zinc by Clarias gariepinus juveniles and Pteridium aquilinum during chronic exposure to sub lethal concentrations. Two experiments were undertaken simultaneously in static renewal bioassays for 28 days.Haematology, histology, zinc accumulation in tissues of C.gariepinus and P. aquilinum were recorded fortnightly. Packed Cell Volume, haemoglobin concentration, Red Blood Cells, White blood cells, Lymphocytes, Neutrophils, Mean Corpuscular Volume, Mean Corpuscular Haemoglobin Concentration and Mean Corpuscular Haemoglobin of C...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134975/plasma-interleukin-1%C3%AE-il-1%C3%AE-concentrations-at-the-different-phases-of-the-oestrus-cycle-in-clomiphene-treated-female-rats
#11
S Co Nwangwu, S J Josiah, C U Urom-Ndubuisi, S I Owoeye, P E Osagiede, A W Oyeyemi, D R Omotosho
Interleukin - 1β (IL-1β) is a signal molecule known for its role in inflammation and immune response. However,there are reports on the possible effects of IL-1β in ovulation and various aspects on female reproduction. It was thereforenecessary to determine plasma IL-1β levels in female rats administered ovulation inducing agent clomiphene citrate. In thiswork, a total of forty (40) female wistar rats weighing between 150g and 225g were used. Twenty of the rats wereadministered 0.14mg/kg clomiphene citrate orally daily for five days while the other twenty which served as control, receivednormal saline...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134974/differences-in-physical-physiological-and-motor-performance-traits-between-volleyball-and-basketball-athletes-in-a-university-in-ghana
#12
A Obour, M O Moses, B Baffour-Awuah, B Asamoah, P K Sarpong, F Osei, L G Akwa, E J Appiah
Physical, physiological and motor performance traits play substantial role in both volleyball (VB) and basketball(BB) competitions. The differences in these traits among University athletes in Ghana have not been reported. Hence, thisstudy documents and compares the physical, physiological and motor performance traits of VB and BB university athletes.Purposive sampling technique involving thirty-five university athletes (24 males and 11 females) with mean age of 21.77 ±2.03years was used. Height, weightn, waist and hip circumferences, waist to hip ratio (WHR), body mass index (BMI), heartrate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP), shoulder muscular endurance (SME), abdominal muscular endurance (AME), left and right Arm Strength, Leg Power, Reaction time, Agility and Speed traits were measured...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134973/effect-of-cortisol-on-plasma-lactate-levels-following-cortisolinduced-hyperglycaemia-in-common-african-toad-bufo-regularis
#13
G O Isehunwa, O T Oladun, J E Akpan, A R A Alada
Previous studies in man have shown that cortisol induces hyperglycemia through gluconeogenesis. However,the metabolic substrates involved in cortisol-induced hyperglycemia and the role of adrenergic receptors in lactate productionin toads have not been well studied. This study investigated the effects of adrenergic receptor blockers in cortisol-inducedhyperglycemia and blood lactate levels in the common African toad (Bufo regularis). Each toad was fasted and anaesthetizedwith sodium thiopentone given intraperitoneally (50mg/kg/i...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134972/oestrual-phase-at-first-exposure-to-predator-induced-stress-determines-pattern-of-alterations-in-oestrous-cycle-and-endocrine-response-in-the-rat
#14
O O Medubi, B O Iranloye, O A Adegoke
Stress has been acknowledged as one of the aetiologies of female reproductive dysfunction, yet the mechanismsinvolved are not totally elucidated. Based on the paucity of information on how predator-induced stress (PS) affects oestrouscycle in rats, this study was designed to investigate the effect of PS on the oestrous cycle in rats. Forty-eight (48) SpragueDawley rats were used for this study. They were randomly divided into Control and PS group. Each group was divided intofour subgroups (n=6/group) according to the phases of oestrous cycle...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134971/detection-of-dna-fragmentation-in-liver-of-goats-exposed-to-lead-poisoning-in-bagega-district-of-zamfara-state-nigeria
#15
A T Jubril, O A Fagbohun, A A Adekola
The ubiquitous presence of lead (Pb) and its release by anthropogenic activities has remained a majorenvironmental pollution risk to both humans and animals. Lead toxicity has been associated with different systemic toxicitiesand biochemical impacts (such as oxidative stress and DNA damaging effects) with dire health consequences. In Nigeria,the health problem associated with lead toxicity has been overwhelming in the Bagega District of Zamfara State whereartisanal gold mining has resulted in widespread environmental lead contamination...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134970/circadian-potassium-excretion-is-unaffected-following-furosemide-induced-increase-in-sodium-delivery-to-the-distal-nephron
#16
B P Ilenwabor, E O Asowata, L F Obika
The mineralocorticoid aldosterone is widely accepted as a key regulator of K+ balance as well as urinary K+excretion. However, recent evidence suggests that the circadian control of K+ excretion is independent of aldosterone. Thedelivery of Na+ to the distal nephron is known to be an important determinant of aldosterone mediated secretion of K+ in thissegment of the nephron. Examining the link between distal Na+ delivery and K+ excretion; and how this link affect circadianK+ excretion will advance what is currently known about the maintenance of K+ homeostasis...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28262857/a-review-on-the-possible-neuroprotective-effects-of-moringa-oleifera-leaf-extract
#17
REVIEW
O O Igado, J K Olopade
Moringa oleifera is an edible plant that has been reputed to be a miracle plant by numerous authors, with effects on practically every body system. Phytochemical analyses have demonstrated that the leaves are rich in various minerals, vitamins and antioxidants. Its use in some continents dates back to Antiquity. Neurodegeneration are chronic diseases of the nervous system. There is currently an increase in the use of natural products to combat these debilitating diseases. So far, no suitable cure has been found, and conditions are managed and the symptoms treated...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28262856/resting-serum-concentration-of-high-sensitivity-c-reactive-protein-hs-crp-in-sportsmen-and-untrained-male-adults
#18
COMPARATIVE STUDY
F A Niyi-Odumosu, O A Bello, S A Biliaminu, B V Owoyele, T O Abu, O L Dominic
There is an inverse relationship between regular physical activity and concentration of serum inflammatory markers, with variations in resting CRP in trained and untrained subjects. The effect of acute and prolonged exercises has been studied on inflammatory markers with dearth of information and controversies on the resting serum values of high sensitivity CRP (hs-CRP). Therefore, this study sought to identify and compare variations that occur in serum levels of high sensitivity CRP in groups of sportsmen (6) and physically active untrained subjects...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28262855/studies-on-zinc-and-copper-ion-in-relation-to-wound-healing-in-male-and-female-west-african-dwarf-goats
#19
COMPARATIVE STUDY
A K Olaifa, S T Fadason
Wound healing remains a challenging clinical problem for which precise and efficient management is essential in order to curtail morbidity and mortality. Wound healing has been shown to depend upon the availability of appropriate trace elements like copper and zinc which serve as enzyme cofactors and structural components in tissue repair. This study aims at evaluating the distribution of zinc and copper found in the hair as well as skin during epidermal wound healing. Adult and healthy West African dwarf (WAD) goats of both sexes fed with concentrate, grass, cassava peel and water ad libitum were used...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28262854/effect-of-insulin-on-visuo-spatial-memory-and-histology-of-cerebral-cortex-in-the-presence-or-absence-of-nitric-oxide-inhibition
#20
I U Yarube, J O Ayo, M Y Fatihu, R A Magaji, I A Umar, A W Alhassan, M Ia Saleh
Insulin has emerged from its traditional 'peripheral' glucose-lowering function to become increasingly regarded as a brain hormone that controls a wide range of functions including learning and memory. Insulin action on learning and memory is linked to nitric oxide (NO) signalling, but its effects on memory and histology of cerebral cortex in conditions of varied NO availability is unclear. This research sought to determine the effect of insulin on visuo-spatial learning, memory and histology of cerebral cortex during NO deficiency...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
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