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Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria

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https://www.readbyqxmd.com/read/30091741/erythrocyte-sedimentation-rates-and-leukogram-changes-in-canine-model-of-osteoarthritis
#1
R A Ajadi, A A Adebiyi, E B Otesile, O B Kasali
Inflammatory markers such as erythrocyte sedimentation rates (ESR) have been evaluated in humans withosteoarthritis (OA). However, there has been no record of evaluation of ESR during OA in dogs. Changes in erythrocytesedimentation rates (ESR) and leukogram functions were evaluated following experimental knee osteoarthritis (OA).Tendogs of both sexes with (mean weight = 12.4 ± 1.8kg) were used. Experimental OA was induced in the right knee, using thegroove model and confirmed radiographically using evidence of joint space narrowing and presence of osteophytes...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/30091740/changes-in-ocular-perfusion-pressure-in-response-to-short-term-isometric-exercise-in-young-adults
#2
C M Ramya, S M Nataraj, R Rajalakshmi, M C Smitha
Ocular Perfusion Pressure (OPP) is the pressure difference between the Mean Arterial Pressure (MAP) and theIntra Ocular Pressure (IOP). Decreased OPP could be a major risk factor for glaucoma. The aim is to study the effect ofIsometric exercise on OPP in apparently healthy young adults. Forty apparently healthy young adult volunteers comprising20 males and 20 females in the age group of 18-21 years were selected among MBBS Phase I students of JSS Medicalcollege, JSSU, Mysore. IOP and BP were recorded. Mean arterial pressure (MAP) and OPP were calculated...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/30091739/moringa-oleifera-ameliorates-histomorphological-changes-associated-with-cuprizone-neurotoxicity-in-the-hippocampal-cornu-ammonis-ca-3-region
#3
G O Omotoso, R M Kolo, T Afolabi, R Jaji-Sulaimon, I T Gbadamosi
Cuprizone-induced neurotoxicity has severally been used to study demyelinating diseases like multiple sclerosis(MS), adversely affecting both the white and grey matters of the brain. Lesions have been observed in different regions ofthe brain including, corpus callosum, neocortex and the hippocampal formation. The current study explored the role ofMoringa oleifera leaf extract in restoring the resultant histomorphological changes in cuprizone-induced hippocampaldamage in Wistar rats. Twenty adult female Wistar rats with average weight of 163...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/30091738/effects-of-clove-and-fermented-ginger-on-blood-glucose-leptin-insulin-and-insulin-receptor-levels-in-high-fat-dietinduced-type-2-diabetic-rabbits
#4
A Abdulrazak, Y Tanko, A Mohammed, K A Mohammed, N M Sada, A Au Dikko
The aimed of this research is to evaluate the effects of clove and fermented ginger supplements on blood glucose,serum insulin, insulin receptor and Leptin levels of high fat diet-induced type 2 diabetes mellitus in rabbits. Clove and gingerare spices with records of medicinal value over decades. Thirty males rabbits weighing, 1-1.5kg were used for the research.Type 2 diabetes was induced by feeding the animals with a high fat diet for a period of eight weeks. Blood glucose levelswere determined after the induction period and rabbits having 140 mg/dL and above were selected for the study...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/30091737/dichlorvos-induced-oxidative-and-neuronal-responses-in-rats-mitigative-efficacy-of-nigella-sativa-black-cumin
#5
A Imam, A Ogunniyi, A Ibrahim, W I Abdulmajeed, L O Aboyeji, A H Lawan, F A Sulaimon, M Y Adana, S M Ajao
Poisoning from Organophosphates (OPs), especially Dichlorvos (DDVP) has become endemic due to theincreasing use in house hold and agricultural pests control, with most marked effects in the nervous system. However, it isevidenced that natural antioxidants are efficacious against OPs toxicity. Thus, this study investigated the possible antidotalefficacy of Nigella sativa oil (NSO) in Dichlovos (DDVP) induced oxidative and neuronal damages in Wistar rats. DDVPwas administered at sub-chronic daily dosage of 8...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/30091736/ameliorative-effects-of-raffia-hookeri-pulp-extract-on-cisplatin-induced-brain-damage-and-consequent-neurobehavioural-changes-in-wistar-rats
#6
O Owoeye, F O Awoyemi, E O Ajiboye
Cisplatin (CIS), a known anticancer drug, has side effects initiated by oxidative damage which hinders its use.Raffia hookeri pulp extract (RHPE), reported to possess antioxidant activity should mitigate cisplatin toxicity. The presentstudy examined the potential of RHPE to reduce brain damage in rats exposed to cisplatin. Forty eight female rats (150 g -220 g) were randomized into four groups (n = 12) viz: Group 1 served as control received distilled water daily, Group 2received 100 mg/kg body weight of RHPE, Group 3 received CIS (7...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/30091735/deteriorating-hemostatic-functions-of-adult-female-wistar-rats-mediated-by-activities-of-non-steroidal-antiinflammatory-drugs-nsaids-piroxicam-and-vitamin-e
#7
E K Nwangwa, K M Anachuna, E I Ekhoye, E Chijiokwu-Agbonifo
The status of hemostatic parameters, are useful physiological markers of organ and tissue damage anddysfunction. This study investigated the effect of Piroxicam on some hemostatic parameters of albino Wistar rats. Twentyfour (24) female albino Wistar rats were used for this study, they were randomly divided into four (4) groups of six (6) ratseach. Group A served as control, Group B and C were rats treated with 0.1 mg/kg and 0.2 mg/kg piroxicam while Group Dserved as 0.2 mg/kg piroxicam treated rats administered with Vitamin E...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/30091734/undergraduate-students-understanding-of-physiology-subject-opinions-and-perception-the-case-of-bayero-university-kano-nigeria
#8
A I Salisu, I J Adama, N W Yusuf, Y Tanko
Human Physiology courses are compulsory in medical education but many students encounter challenges instudying them. This study investigates understandings, opinions and perceptions of students about physiology subject andthe challenges they encounter in their study. Two hundred and eighty (280) students were interviewed using structuredquestionnaire. The data were analyzed using IBM SPSS statistics 22. The mean age of the students was 22.8 ± 4.1 years.Males constituted 174(62.1%), while females were 106 (37...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/30091733/spermatotoxicity-and-testicular-pathology-in-wistar-strain-rats-fed-graded-levels-of-pigeon-pea-diet
#9
K Soetan, O S Ajani, O C Akinsulie, M O Tijani
Pigeon pea is an important grain legume in the tropics and subtropics and it is a valuable source of low-cost plantprotein for humans and animals, but it remains an underutilized legume. Effects of feeding graded levels of raw pigeon pea seed inclusion diets on testicular function in Wistar rats was investigated. Thirty male Wistar rats weighing between 120 and 160 g were assigned into six groups (A-F) of 5 rats each.
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/30091732/serum-levels-of-inflammatory-cytokines-in-helminth-infested-pregnant-women-and-cord-blood-of-their-babies-in-relation-to-pregnancy-outcome
#10
O A Olateru-Olagbegi, E C Omoruyi, R A Dada, V F Edem, O G Arinola
Pregnancy places a very high demand on physical, physiological and immunological responses of females,especially when aggravated by parasitic infestation. There is strong evidence that maternal infestations with helminth haveprofound effects on immunity to helminths and other pathogens. This case-control study involved 245 pregnant women aged18-40 years (>30 weeks of gestation) recruited from three secondary level hospitals in Ibadan, Nigeria. Morning stoolsamples collected from pregnant women were examine for intestinal helminths using formol-ether concentration method...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/30091731/metabolic-fate-of-the-glucose-taken-up-by-the-intestine-during-induced-hyperglycaemia-in-dogs
#11
S T Shittu, A R A Alada, D D O Oyebola
Available data showed that the intestine increases it glucose uptake in response to hyperglycemia induced by anycause. However, what the intestine does with the glucose is not known. This study investigated the metabolic fate of theglucose taken up by the intestine during hyperglycaemia in dogs. Experiments were carried out on fasted, male, anaesthetizedmongrel dogs divided into 4 groups. The control (group 1, n=5) received normal saline (0.2 ml/kg) while groups 2-4(subdivided into two as low or high dose, n=5 each) received adrenaline (1 μg/kg or 5 μg/kg), glucagon (3 ng/kg or 8 ng/kg)and glucose (10 mg/kg/min or 20 mg/kg/min)...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/30091730/haemostatic-indices-as-markers-for-monitoring-pulmonary-tuberculosis-treatment
#12
Patience A Akpan, Josephine O Akpotuzor, Eme E Osim
Tuberculosis (TB) is an infectious disease inducing a state of chronic inflammation which could affect thehaemostatic mechanism as part of host defences against infection. Proper diagnosis and monitoring of tuberculosis patientsundergoing therapy is still a challenge especially in a poor resource country such as Nigeria. This study aims to assess somehaemostatic indices of tuberculosis patients and their possible use as markers in monitoring response to anti-tuberculosistreatment. One hundred and twenty TB patients aged 15-60 years and 120 apparently healthy (control) subjects age andgender-matched were studied...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/30091729/ahaptoglobinaemia-in-a-nigerian-cohort
#13
Chidiebere C Eluke, Blessing C Eluke, Ndidiamaka I Okereke, Chukwugozie Okwuosa, Silas Ufelle
Ahaptoglobinaemia have been indicated in blacks from West Africa. Owing to the clinical and biologicimportance of haptoglobin (hpt), this work explores the situation in a Nigerian cohort since there are no published values ofhaptoglobin levels of individuals in this locality. The study was aimed at determining the amount of haptoglobin in the bloodof normal healthy Nigerians. Haptoglobin was quantitatively estimated in one hundred and fifty-two apparently healthyindividuals using highly sensitive immunoassay technology...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/30091728/effect-of-chronic-caffeine-consumption-on-cardiac-tissue-metabolism-in-the-rabbit
#14
E W Nabofa, A R A Alada
Previous studies on the ability of caffeine to enhance endurance and boost performance have focused on theenergy substrates that are utilized by the skeletal muscle and the brain but nothing of such has been reported on cardiactissue. This study was designed to investigate the effect of caffeine on cardiac tissue metabolism in the rabbit. The study wascarried out on adult male New Zealand rabbits divided into 3 groups (n=5). Group I rabbits served as control and were given0.5ml/Kg of normal saline while group II and III rabbits were administered with 2mg/Kg and 6mg/kg of caffeine respectivelyfor 28 days...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/30091727/heparin-enhances-the-effects-of-mesenchymal-stem-cell-transplantation-in-a-rabbit-model-of-acute-myocardial-infarction
#15
Behshid Ghadrdoost, Roya Khoshravesh, Nahid Aboutaleb, Abdolah Amirfarhangi, Somayeh Dashti, Yaser Azizi
Stem cell transplantation in combination with administration of bioactive compounds has shown promising resultsin treating myocardial infraction (MI). In the current study, we investigated the effect of combining mesenchymal stem cells(MSCs) transplantation with heparin into the infarcted heart rabbits. For this purpose, 35 male New Zealand white rabbitswere randomly divided into five groups: sham, MI, MI+ MSCs, MI+ heparin and MI+MSCs+ heparin. MI was induced by30 min ligation of the left anterior descending coronary artery...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/30091726/effect-of-caffeine-on-serum-tumour-necrosis-factor-alpha-and-lactate-dehydrogenase-in-wistar-rats-exposed-to-cerebral-ischaemia-reperfusion-injury
#16
Mubarak Muhammad, A B El-Ta'alu, M A Mohammed, I U Yarube, J M Nuhu, I Yusuf, U A Daneji
Caffeine is known to confer neuro-protection via A1 and A2A adenosine receptor antagonism in which adenosine neuro-modulates excitotoxic release of glutamate. Currently, it is unclear whether caffeine modulates inflammation in ischaemic stroke model. The present study examined effects of caffeine following ischaemia-reperfusion injury on neuro-inflammatory tumour necrosis alpha (TNF-α), lactate dehydrogenase (LDH), as well as effect of caffeine against brain ischaemic damage on histology. Thirty three adult male Wistar rats (180-300 g) were used in this study...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485645/correlation-of-serum-estradiol-and-duration-of-anastrazole-therapy-with-treatment-related-adverse-effects-among-postmenopausal-breast-cancer-women-a-cross-sectional-study
#17
M B Abubakar, S H Gan
Although anastrozole (Anas) plays a key role in the management of endocrine sensitive post-menopausal (PM) breast cancer (BC), there is much variability in its efficacy and tolerability. Anas-associated musculoskeletal symptoms (MS) and other adverse reactions, such as hot flashes (HF) and vaginal dryness/dyspareunia (VDD), are common and can affect the quality of life of BC patients, even sometimes leading to treatment withdrawal. The aim of this study was to determine the clinical and demographic factors associated with these adverse events...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485644/serum-troponin-i-levels-among-hypertensive-military-service-personnel-at-a-military-health-facility-in-abuja-nigeria
#18
G O Nwagbara, Abiodun Mathias Emokpae
Hypertension constitutes one of the major metabolic disease in Nigeria especially among military personnel and their families. Myocardial infarction and other cardiovascular diseases may occur in this group of patient due to uncontrolled or poorly controlled hypertension. The objective of this study was to determine serum cardiac Troponin I (cTnI), levels in hypertensive Nigerian Military service personnel attending clinic in a military Health facility.  We measured the serum levels of cTnI in 126 hypertensive subjects [76 males (19-73 years) and 50 females (26-77years)] and 82 normotensive controls [41 males (19-60years) and 41 females (18-53years)] using Latex Enhanced Immunoturbidimetry technique...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485643/ionoregulatory-disruption-and-acetylcholinesterase-activity-in-aluminium-toxicity-effects-of-vitamins-c-and-e
#19
R N Ugbaja, T O Olaniyan, O K Afolabi, B O Onunkwor, O A Dosumu, T F Akinhanmi, A Y Tiamiyu, N O Aliyu-Banjo
To investigate the effects of vitamin C and E on electrolyte profile and the activity of acetylcholinesterase (AChE) in Aluminium (Al) chloride exposed rats, thirty-six male rats were used for this study. The animals were randomly grouped into six (n=6); group I (Control) was given normal saline. Group II (Al only) was exposed to 20mg/kg body weight (BW) of Al. Groups III (Vitamin C only) and IV (Vitamin E only) were administered 200mg/kg BW of vitamin C and vitamin E respectively. Groups V (Al + Vit C) and VI (Al + Vit E) were exposed to 20mg/kg Al and were treated with 200mg/kg vitamin C and vitamin E respectively...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485642/modulatory-role-of-rutin-supplement-on-open-space-forced-swim-test-murine-model-of-depression
#20
Y Yusha'u, U A Muhammad, M Nze, J M Egwuma, O J Igomu, M Abdulkadir
Flavonoids have been demonstrated to possess an anti-depressant effect and less adverse effects than tricyclic anti-depressants. For this reason, flavonoids in natural products have attracted growing attention. Rutin is a glycoside flavonoid which belongs to an important class of flavonoids, abundantly found in plants, such as buckwheat seeds, asparagus, red pepper, apples, citrus fruits and leaves of many herbs such as rosemary, dandelion or sage, and black and green tea.  It is a vital nutritional component of food stuff...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
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