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Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria

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https://www.readbyqxmd.com/read/27574771/serum-levels-of-selected-vitamins-and-trace-elements-in-nigerian-consumers-of-alcoholic-beverage-a-suggestion-for-dna-hypomethylation
#1
A N Ude, V F Edem, A A Onifade, O G Arinola
Folic acid, vitamins and Zinc play essential role in DNA methylation but alcohol consumption is known to affectthe levels of these micronutrients leading to risk of developing various illnesses and certain cancers. This study determinedthe levels of DNA methylation dependent-micronutrients (folate, vitamin B12, vitamin B6, zinc and selenium) andhomocysteine as a suggestion for DNA methylation status in Nigerian alcohol consumers compared with non-consumers ofalcohol. Venous blood (5ml) was obtained from thirty-four males that consume alcoholic beverages for at least 10 years andthirty-two male controls that did not consume alcoholic beverages at least 10 years...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574770/antidepressant-like-potentials-of-buchholzia-coriacea-seed-extract-involvement-of-monoaminergic-and-cholinergic-systems-and-neuronal-density-in-the-hippocampus-of-adult-mice
#2
S A Onasanwo, S O Faborode, K O Ilenre
Buchholzia coriacea, taken by elderly, has phytochemicals that have neuro-active metabolites, and the folkloredocumented its use in neuro-behavioral despairs. Previous study in our laboratory shows that methanol extracts of Buchholziacoriacea (MEBC) seeds possess antidepressant-like potentials in laboratory rodents. This present study was conducted toinvestigate the probable mechanism(s) of action by which MEBC potentiates its effects using laboratory rodents.Involvements of serotonergic, cholinergic and adrenergic systems were studied using Forced Swimming Test (FST) and TailSuspension Test (TST) models of behavioral despair...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574769/conception-of-pharmacological-knowledge-and-needs-amongst-nigerian-medical-students-at-lagos-state-university-college-of-medicine-implication-for-future-biomedical-science-in-africa
#3
Luther Agbonyegbeni Agaga, Theresa Adebola John
In Nigeria, medical students are trained in more didactic environments than their counterparts in researchintensive academic medical centers. Their conception of pharmacology was thus sought. Students who are taking/have takenthe medical pharmacology course completed an 18-question survey within 10min by marking one/more choices fromalternatives. Instructions were: "Dear Participant, Please treat as confidential, give your true view, avoid influences, avoidcrosstalk, return survey promptly." Out of 301 students, 188 (62...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574768/evaluation-of-body-mass-index-and-plasma-lipid-profile-in-boerboel-dogs
#4
Rasheed Adetola Ajadi, Rashidat Oluwatobiloba Ashogbon, Abisola Abosede Adeniyi
This study evaluated the body mass index (BMI) and plasma lipid profile in Boerboel dogs. Body weights (BW),height (H) at shoulder and waist circumference (WC) were obtained from fifty-three Boerboels to determine the BMI while,body condition score (BCS) was determined subjectively. Also 5mls of blood was obtained from the dogs for determinationof total cholesterol (TC), triglycerides (TRIG), low density lipoproteins (LDL) and high density lipoproteins (HDL). Datawere presented as means ± standard deviation and results were compared using analysis of variance...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574767/resveratrol-protects-rabbits-against-cholesterol-diet-induced-hyperlipidaemia
#5
Y Tanko, A Jimoh, A Ahmed, A Mohammed, J O Ayo
The excessive consumption of high cholesterol diet has been associated with an increased incidence oflipidaemia. Lipidaemia is enhanced by formation of oxidative stress, lipid peroxidation and hyperglycaemia. The aim ofthese experiments was to investigate the protective effect of resveratrol co-administered with cholesterol diet inducedhyperlipidaemia in rabbits. Thirty rabbits divided into six groups of five animal (group= 5) each: group 1 = normal control,group 2 = cholesterol diet/high fat diet group only (HFD), group 3 = resveratrol 200 mg/kg (R200), group 4 = resveratrol400 mg/kg (R400), group 5 = HFD + R200 and group 6 = HFD + R400...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574766/sports-participation-anthropometric-and-physiological-profiles-of-university-athletes
#6
M O Moses, B M Duduyemi
Sports participation has been adjudged to enhance healthy living. This study described anthropometric andphysiological (A-P) profiles of university athletes based on types of sports (ToS) and duration (in years) of participation(DoP). One hundred and twenty-nine athletes (69 males, 60 females), aged l5-36, who had played averagely for5.78±0.29years, from nine games and preparing for Ghana University Sports Association (GUSA) 2014 participated in thestudy. Ex-post facto research design was adopted. Data on ToS, DoP, age, height, weight, body mass index, waist and hipcircumference, body fat and water, blood pressure and heart rate were collected, entered into SPSS Data Editor 17...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574765/effect-of-vitamin-c-supplementation-on-platelet-aggregation-and-serum-electrolytes-levels-in-streptozotocin-induced-diabetes-mellitus-in-rats
#7
Daniel U Owu, Chukwuemeka R Nwokocha, Daniel E Ikpi, Emmanuel I Ogar
Diabetes mellitus (DM) is a disease condition characterised by hyperglycemia; free radical and abnormalhaematological indices. Vitamin C can reduce free radical generation and ameliorate adverse conditions of diabetes mellitus.The aim of the present study is to investigate the effect of vitamin C on platelet aggregation and electrolyte levels in Type 1DM. Male Wistar rats were divided into four groups namely control, DM, DM +Vitamin C and Vitamin C groups. Rats weremade diabetic with a single dose of streptozotocin (65 mg/kg) intraperitoneally...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574764/plasma-adenosine-deaminase-enzyme-reduces-with-treatment-of-pulmonary-tuberculosis-in-nigerian-patients-indication-for-diagnosis-and-treatment-monitoring
#8
O Ige, V F Edem, O G Arinola
Tuberculosis(TB)-specific host biomarkers for diagnosis and monitoring of treatment response have been identified as priorities for TB research. Macrophage and T cell lymphocytes play vital roles in Mycobacterium tuberculosis immune response and their associated biomarkers could form good candidates for diagnosis and treatment monitoring. The enzyme adenosine deaminase (ADA) is produced mainly by monocytes and macrophages and increase in biological fluids in the course of infection with microorganisms infecting macrophages...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574763/frequency-of-hepatitis-b-and-c-co-infection-in-chronic-liver-disease-patients-in-calabar-cross-river-state-nigeria
#9
M Kooffreh-Ada, D C Okpokam, Z A Okaormhe, V U Nna
Hepatitis B (HBsAg) and C (HCV) virus are becoming a significant causative factors in the aetiology of chronic liver disease (CLD) worldwide. However, the information on the frequency of HBsAg and HCV virus co-infection in CLD is sparsely reported in Nigeria. In this study, we assessed the frequency of HBsAg and HCV co-infection in CLD. One hundred and eleven subjects aged 19 - 76 years, comprising of 76 CLD patients and 35 apparently healthy subjects without CLD were tested for both HBsAg and HCV virus antibodies using ELISA test kits...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574762/effect-of-surgical-and-immunological-castration-on-haematological-variables-reproductive-hormones-and-ejaculate-characteristics-in-mongrel-dogs
#10
Temitope A Ajadi, Oladele S Gazal
Welfare concerns are growing regarding surgical castration (SC) in pets, necessitating the need for non-surgical alternatives. Administration of vaccines against gonadotropins releasing hormone (GnRH) have been reported as alternative to SC. This study determined the effect of surgical and immunological castrations (IC) on complete blood counts, plasma testosterone (T), luteinizing hormone (LH) concentrations and ejaculate characteristics in mongrel dogs. Ten intact male dogs were randomly divided into two groups (A & B)...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574761/bronchoalveolar-lavage-fluid-cellular-and-haematological-changes-in-different-types-of-caprine-pneumonia
#11
A T Jarikre, O B Emikpe, G O Ohore, A T Akinremi, O S Akpavie
Goats in the tropics are often reared under the traditional extensive and semi-intensive management systems. These and other factors influence the pattern of pneumonia complex in goats. We investigated the bronchoalveolar lavage fluid (BALf) cellular changes and haematological response in different types of caprine pneumonia in Nigeria. Haematological indices and BALf cells were analysed from 300 goats randomly selected from 700 goats comprising different breed, age and body scores. The pneumonia status was well characterised using standard pathological tools...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574760/restraint-stress-impairs-glucose-homeostasis-through-altered-insulin-signalling-in-sprague-dawley-rat
#12
Ayodele O Morakinyo, Kolawole I Ajiboye, Gabriel O Oludare, Titilola A Samuel
The study investigated the potential alteration in the level of insulin and adiponectin, as well as the expression of insulin receptors (INSR) and glucose transporter 4 GLUT-4 in chronic restraint stress rats. Sprague-Dawley rats were randomly divided into two groups: the control group and stress group in which the rats were exposed to one of the four different restraint stressors; 1 h, twice daily for a period of 7 days (S7D), 14 days (S14D) and 28 days (S28D). Glucose tolerance and insulin sensitivity were evaluated following the final stress exposure...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574759/the-deterioration-seen-in-myelin-related-morphophysiology-in-vanadium-exposed-rats-is-partially-protected-by-concurrent-iron-deficiency
#13
Ifukibot Levi Usende, Dominque F Leitner, Elizabeth Neely, James R Connor, James O Olopade
Oligodendrocyte development and myelination occurs vigorously during the early post natal period which coincides with the period of peak mobilization of iron. Oligodendrocyte progenitor cells (OPCs) are easily disturbed by any agent that affects iron homeostasis and its assimilation into these cells. Environmental exposure to vanadium, a transition metal can disrupt this iron homeostasis. We investigated the interaction of iron deficiency and vanadium exposure on the myelination infrastructure and its related neurobehavioural phenotypes, and neurocellular profiles in developing rat brains...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574758/chemopreventive-effect-of-tadalafil-in-cisplatin-induced-nephrotoxicity-in-rats
#14
A A Adeneye, A S Benebo
Nephrotoxicity remains a common untoward effect of cisplatin therapy with limited effective chemopreventive options available till date. This study aims to evaluate the possible chemopreventive effect and mechanism(s) of action of 2 mgkg-1 and 5 mgkg-1 of Tadalafil in cisplatin-induced nephrotoxic rats. In this study, twenty-five male Wistar rats were randomly divided into five groups (n = 5 rats per group) and daily pretreated with oral doses of distilled water (10 mLkg-1), ascorbic acid (100 mgkg-1), Tadalafil (2 mgkg-1 and 5 mgkg-1) for 7 days before cisplatin (5 mgkg-1, intraperitoneal) was administered...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27507782/effect-of-ethanolic-leaf-extract-of-senna-fistula-on-some-haematological-parameters-lipid-profile-and-oxidative-stress-in-alloxan-induced-diabetic-rats
#15
Tayo Maryam Ayinla, Victor B Owoyele, Toyin M Yakubu
Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. The disease is also known to adversely affect some haematological parameters and cause dyslipidemia. This study was designed to investigate the effect of chronic administration of ethanolic leave extract of Senna fistula on haematological values, oxidative stress and dyslipidemia in experimental diabetic rats. Twenty-four albino rats weighing 120-150 g were divided into 4 experimental groups of six rats each; control, diabetic untreated, diabetic treated with glibenclamide and diabetic treated with 100 mg/kg b...
2015: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27507781/genistein-precipitated-hypothyroidism-altered-leptin-and-c-reactive-protein-synthesis-in-pregnant-rats
#16
F O Awobajo, B O Onokpite, Y M Ali, T A Babaleye, P O Uzor, K O Tijani
Genistein is an isoflavone constituent of soya. This study examined the mechanism by which genistein produced adverse effects in pregnant laboratory rats. Pregnant rats were divided into control (Con) and genistein (Gen) force fed (2 mg/kg) groups. At terminal gestation day (GD) ranging from 0-20, the rats were sacrificed, and blood samples and amniotic fluids were collected. Thyroid hormone, C-reactive protein (CRP) and leptin assay was carried using the blood samples. Leptin was also assayed in the placenta and amniotic fluid supernatant...
2015: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27507780/healing-potentials-of-oral-moringa-oleifera-leaves-extract-and-tetracycline-on-methicillin-resistant-staphylococcus-aureus-infected-wounds-of-wistar-rats
#17
Oghenemega D Eyarefe, Aderayo Idowu, Jeremiah M Afolabi
The effects of oral dose of aqueous extract of Moringa oleifera and tetracycline antibiotics on cutaneous wounds infected with Staphylococcus aureus were studied in eighteen adult wistar rats (159±31.5g) randomized into three groups: Group A, n = 6, Moringa oleifera-(300 mg/kg). Group B, n = 6, tetracycline (9.4 mg/kg) and Group C, n = 6, Sterile water (control). Six millimetres diameter nape wound, created on each rat under 2% xylazine (5 mg/kg) and 5% ketamine (35 mg/kg), was contaminated with Staphylococcus aureus (108 Colony Forming Unit (CFU)...
2015: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27507779/honey-attenuates-the-detrimental-effects-of-nicotine-on-testicular-functions-in-nicotine-treated-wistar-rats
#18
T A Kolawole, W A Oyeyemi, C Adigwe, B Leko, C Udeh, D V Dapper
Effect of honey on reproductive functions of male rats exposed to nicotine was examined in this study. Thirty-two adult male wistar rats (n=8/Group) were grouped as Control (distilled water), Nicotine (1.0mg/kg bwt), Honey (100mg/kg bwt) and Nicotine with Honey. The animals were orally treated for 35 days consecutively. Epididymis sperm motility, viability, morphology and counts were estimated, serum Follicle Stimulating Hormone (FSH), Leutinizing Hormone (LH) and Testosterone were assayed using ELISA method and testicular histology were also assessed...
2015: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27507778/vitamin-c-prevents-sleep-deprivation-induced-elevation-in-cortisol-and-lipid-peroxidation-in-the-rat-plasma
#19
L A Olayaki, S O Sulaiman, N B Anoba
Sleep deprivation (SD) is biological stressor that alters metabolic parameters, induced oxidative stress and lipid peroxidation. Previous studies have shown that antioxidants substances such as melatonin, tryptophan, vitamin E and vitamin C improved stress tolerance in laboratory animals. In this study, we examined the potential protective effects of administration of vitamin C on acute and chronic sleep deprivation-induced metabolic derangement. In addition, possible processes involved in vitamin C effects on acute and chronic sleep deprivation-induced metabolic derangement were determined...
2015: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27506178/effects-of-maternal-dexamethasone-exposure-during-lactation-on-metabolic-imbalance-and-oxidative-stress-in-the-liver-of-male-offsprings-of-wistar-rats
#20
S O Jeje, Yinusa Raji
It has been reported in human and animal studies that early exposure to glucocorticoids could retard growth and subsequent development of cardio metabolic diseases. Chronic exposure to glucocorticoids induced oxidative stress. Therefore, the role of oxidative stress in some of the observed metabolic imbalance needs to be elucidated. This study examined the effects of lactational dexamethasone exposure on metabolic imbalance and oxidative stress marker in the liver of male offspring of exposed mother. Twenty lactating dams were divided into 4 groups of 5 animals each...
2015: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
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