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Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria

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https://www.readbyqxmd.com/read/29485645/correlation-of-serum-estradiol-and-duration-of-anastrazole-therapy-with-treatment-related-adverse-effects-among-postmenopausal-breast-cancer-women-a-cross-sectional-study
#1
M B Abubakar, S H Gan
Although anastrozole (Anas) plays a key role in the management of endocrine sensitive post-menopausal (PM) breast cancer (BC), there is much variability in its efficacy and tolerability. Anas-associated musculoskeletal symptoms (MS) and other adverse reactions, such as hot flashes (HF) and vaginal dryness/dyspareunia (VDD), are common and can affect the quality of life of BC patients, even sometimes leading to treatment withdrawal. The aim of this study was to determine the clinical and demographic factors associated with these adverse events...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485644/serum-troponin-i-levels-among-hypertensive-military-service-personnel-at-a-military-health-facility-in-abuja-nigeria
#2
G O Nwagbara, Abiodun Mathias Emokpae
Hypertension constitutes one of the major metabolic disease in Nigeria especially among military personnel and their families. Myocardial infarction and other cardiovascular diseases may occur in this group of patient due to uncontrolled or poorly controlled hypertension. The objective of this study was to determine serum cardiac Troponin I (cTnI), levels in hypertensive Nigerian Military service personnel attending clinic in a military Health facility.  We measured the serum levels of cTnI in 126 hypertensive subjects [76 males (19-73 years) and 50 females (26-77years)] and 82 normotensive controls [41 males (19-60years) and 41 females (18-53years)] using Latex Enhanced Immunoturbidimetry technique...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485643/ionoregulatory-disruption-and-acetylcholinesterase-activity-in-aluminium-toxicity-effects-of-vitamins-c-and-e
#3
R N Ugbaja, T O Olaniyan, O K Afolabi, B O Onunkwor, O A Dosumu, T F Akinhanmi, A Y Tiamiyu, N O Aliyu-Banjo
To investigate the effects of vitamin C and E on electrolyte profile and the activity of acetylcholinesterase (AChE) in Aluminium (Al) chloride exposed rats, thirty-six male rats were used for this study. The animals were randomly grouped into six (n=6); group I (Control) was given normal saline. Group II (Al only) was exposed to 20mg/kg body weight (BW) of Al. Groups III (Vitamin C only) and IV (Vitamin E only) were administered 200mg/kg BW of vitamin C and vitamin E respectively. Groups V (Al + Vit C) and VI (Al + Vit E) were exposed to 20mg/kg Al and were treated with 200mg/kg vitamin C and vitamin E respectively...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485642/modulatory-role-of-rutin-supplement-on-open-space-forced-swim-test-murine-model-of-depression
#4
Y Yusha'u, U A Muhammad, M Nze, J M Egwuma, O J Igomu, M Abdulkadir
Flavonoids have been demonstrated to possess an anti-depressant effect and less adverse effects than tricyclic anti-depressants. For this reason, flavonoids in natural products have attracted growing attention. Rutin is a glycoside flavonoid which belongs to an important class of flavonoids, abundantly found in plants, such as buckwheat seeds, asparagus, red pepper, apples, citrus fruits and leaves of many herbs such as rosemary, dandelion or sage, and black and green tea.  It is a vital nutritional component of food stuff...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485641/anthropometric-indices-and-serum-micronutrient-status-of-helminth-infected-school-children-from-semi-urban-communities-in-southwestern-nigeria
#5
K S Akinwande, O A Morenikeji, O G Arinola
Adequate nutrition is essential for normal growth of children but helminth infection is proposed to cause nutritional deficiencies. This study was carried out to assess the nutritional status of helminth infected school aged children in semi-urban communities of South-West Nigeria. Two hundred children from primary schools in Akinyele Local Government of Oyo State, Nigeria participated in the study. Anthropometric measurements were analyzed using the WHO AnthroPlus software. Kato Katz method was used to detect ova of helminths in the stool while serum levels of iron, zinc, selenium, ferritin, transferrin, vitamin A, vitamin C and haptoglobin were measured using High Performance Liquid Chromatography and Atomic Absorption Spectophotometry as appropriate...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485640/immunolocalization-and-distribution-pattern-of-estrogen-er%C3%AE-and-er%C3%AE-and-progesterone-pr-receptors-along-the-excurrent-duct-of-male-greater-cane-rat-thryonomys-swinderianus
#6
A O Adebayo, A K Akinloye, A O Ihunwo, V O Taiwo, B O Oke
The excurrent duct, which plays vital roles in the reproductive biology of all male mammals, shows some structural variations among different species. Some hormones such as testosterone, estrogen and progesterone, through their different receptors, have been known to be involved in the normal functioning of the excurrent duct. Here we evaluated the presence, localization and patterns of distribution of three hormone receptors, estrogen alpha (ERα), estrogen beta (ERβ) receptors and progesterone receptors (PR) along the excurrent duct of sexually matured male greater cane rats...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485639/effects-of-salmon-calcitonin-and-omega-3-fatty-acids-on-glucoregulatory-indices-lipid-profile-and-antioxidant-markers-in-experimental-knee-osteoarthritis-in-wistar-rats
#7
W J Adeyemi, L A Olayaki
It has been opined that a combined therapeutic approach should be considered in the optimal management ofosteoarthritis (OA). Therefore, the study investigated the effects of salmon calcitonin (Sct) and/or omega-3 fatty acids (N-3), relative to diclofenac sodium (DF) on selected biochemical parameters in induced osteoarthritic rats. Forty (40) adultmale Wistar rats were used for this study. The rats were divided into 8 groups (n=5), viz: Group 1-Normal control; Group 2-OA control; Group 3-OA+N-3 (200 mg/kg, p...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485638/potential-link-between-complement-5a-receptor-and-mood-disorders-in-mouse-exposed-to-experimental-malaria-in-utero
#8
Akhabue K Okojie, O E Okobi, Hamza Dar, Hurmat Malik, Mehreen Arif, Khalid Rauf, Eghosa E Iyare
In Africa, a large number of pregnancies are exposed to Plasmodium falciparum infection. The in-utero environment extremely influences childhood neurodevelopment and behaviour. The complement 5a receptor (C5aR) is linked to several disease conditions. However, the influence of Plasmodium berghei during pregnancy on maternal complement 5a receptor and subsequently on fetal behaviour is unknown. Pregnant mice were intra-peritoneally inoculated on gestational day 13 with 1.02x105 infected red blood cells (iRBCs)...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485637/influence-of-tramadol-on-anaesthetic-indices-and-physiological-parameters-of-epidural-lignocaine-in-west-african-dwarf-sheep-undergoing-laparo-ovariectomy
#9
R A Ajadi, O A Sobanke, A A Adeniyi, A A Adeusi, A Adebiyi, A K Akinloye
The influence of tramadol on the anaesthetic indices and physiological parameters of epidural injection of lignocaine was evaluated in West African Dwarf (WAD) sheep undergoing laparo-ovariectomy. Ten female sheep weighing (16.2 ± 1.3 kg) were randomly allocated into anaesthesia with epidural injection of lignocaine (4mg/kg) (LIG), or lignocaine (2mg/kg) and tramadol (2mg/kg) (LIG-TRA). Following anaesthesia, they were aseptically prepared and subjected to laparo-ovariectomy. Behavioural changes were noted as they occur, and onset of drug action (OAN) (time between epidural injection and loss of pedal reflex), duration of analgesia (DAN) (time between disappearance and reappearance of pedal reflex) were determined...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485636/glucose-tolerance-in-non-diabetic-adult-subjects-of-an-urban-west-african-population
#10
B Awede, S Lawani, G Adehan, J Akakpo, E Dossou, M Amoussou-Guenou, F Djrolo
The present study was carried out to determine glucose tolerance and insulin sensitivity in adult subjects of a west African population. 103 subjects recruited in the town of Cotonou were included in the study. After anthropometric measurement, they were subjected to an oral glucose tolerance test (OGTT). Serum glucose and insulin levels were determined throughout the OGTT. Homeostatic model of assessment of insulin resistance (HOMA-IR), MATSUDA insulin sensitivity index (MATSUDA-ISI) and insulinogenic index (IGI) have been determined to evaluate insulin sensitivity and beta cells function...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485635/skull-typology-and-morphometrics-of-the-nigerian-local-dog-canis-lupus-familiaris
#11
Olumayowa O Igado
Understanding skull anatomy and morphometry is crucial to the diagnosis and treatment of some osteology disorders. This study investigated the morphometry and skull typology of the skull of the Nigerian local dog as a skull prototype for the dolichocephalic breed of dogs. A total of sixteen adult dogs (7 males, 9 females), of about 2 years were used. A total of 20 parameters were measured on each skull, and two indices (cephalic and orbital) calculated. The males had higher values for nine parameters (two of which were calculated indices), including the maximum width of the skull, length of the mandibular symphysis, height of the tympanic bulla and height of the external auditory opening, although no statistically significant difference was observed (p > 0...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485634/melatonin-modulates-neuronal-mitochondria-function-during-normal-ageing-in-mice
#12
A J Idowu, S L Kumar, B Yidong, R Russel
Mitochondrial dysfunction has been shown to be associated with normal ageing and may account for age-related vulnerability to disease. The increasing number of old people worldwide has created the need to find effective therapeutic agents to reduce the incidence of age-related disease. In the current report, we carried out an assessment of mitochondrial function in established young, middle-aged and old synaptosomal mitochondria bearing cybrids without or with melatonin treatment. The cybrids were generated by transferring isolated mitochondria from synaptosomes of brain cortical cells in mice to rho-zero mtDNA-less cells...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485633/effects-of-fermented-ginger-rhizome-zingiber-officinale-and-fenu-greek-trigonella-foenum-graceum-supplements-on-oxidative-stress-and-lipid-peroxidation-biomarkers-in-poloxamer-407-induced-hyperlipidemic-wistar-rats
#13
Y Tanko, A Kabiru, A Abdulrasak, K A Mohammed, A I Salisu, A Jimoh, N M Gidado, N M Sada
This research was aimed at investigating the Effects of Fermented Ginger Rhizome (Zingiber officinale) and Fenu Greek (Trigonella foenum-graceum) on Oxidative stress and Lipid Peroxidation Biomarkers in Poloxamer 407Induced-Hyperlipidemic Wistar Rats. Hyperlipidaemia was induced with poloxamer P407 (1.5 g/kg   b.w. i.p.) The Animals were grouped into six of five animals each group. Group 1 normal control, Group 2 served as the hyperlipidemic control, Group 3 administered 0.26 g/kg cholestyramine, Group 4 fed on Fenugreek 25% supplement...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485632/effects-of-lipopolysaccharide-and-high-saline-intake-on-blood-pressure-angiogenic-factors-and-liver-enzymes-of-pregnant-rats
#14
G O Oludare, O J Ilo, B A Lamidi
This study investigated the effect of high salt water intake and lipopolysaccharide injection as probable rat models of preeclampsia during pregnancy. Thirty-three female Sprague-Dawley rats weighing between 150-170g were divided into 4 groups of the control (normal saline), high salt water intake (1.8% NaCl from days 13-18 of pregnancy), lipopolysaccharide group (40 µg/kg b.w. ip injection from day 16-18 of pregnancy) and high salt water (1.8% NaCl) and lipopolysaccharide injection (40 µg/kg b.w i.p. from days 16-18 of pregnancy)...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485631/a-comparison-of-surface-infrared-with-rectal-thermometry-in-dogs
#15
T O Omóbòwálé, B N Ogunro, E A Odigie, P I Otuh, B O Olugasa
Accurate determination of temperature is crucial in the diagnosis of febrile conditions. Although fewer techniques have proven as useful and reliable a predictor of core body temperature as the rectal thermometry, the process of obtaining the rectal temperature could be stressful in dogs. The infrared thermometry is a noncontact device used for measuring body temperature, with advantages which include speed, convenience, and reduced stress to the animals and reduced occupational risks to the animal handler...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485630/differential-kolaviron-attenuated-contractile-responses-to-agonists-on-isolated-rabbit-aorta-in-na-k-pump-blockade
#16
O K Uche, J O Ofeimun
The mechanism of kolaviron-induced vascular smooth muscles (VSMs) responses has not been fullycharacterised. The present study investigated the effect and mode of action of kolaviron a biflavanoid-complex and majorcomponent of Garcinia Kola-fraction on differential contractile responses to agonists-[phenylephrine (PHE) and histamine(HIST)] on VSMs of rabbit isolated aortic rings in K+-free physiological salt solution (KFPSS). Cumulative concentrationresponses to PHE and HIST were examined on 2 mm ring segments of the thoracic aortae which were suspended in 20 mlorgan baths containing physiological salt solution (PSS) for measurement of isometric contractions, at 370C and pH 7...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29485629/osmoregulatory-adaptations-during-lactation-thirst-arginine-vasopressin-and-plasma-osmolality-responses
#17
Emmanuel Amabebe, F O Robert, L F O Obika
Pregnancy and lactation are accompanied by an increase in circulating blood volume secondary to a 10 mOsmol/kgH20 decrease in plasma osmolality, decrease in the osmotic threshold for thirst and arginine vasopressin (AVP) release, prolactin-induced AVP, oxytocin and aldosterone release, as well as increased water intake and retention. The increased blood volume as a result of increased thirst; drinking and fluid retention could be beneficial for milk production and secretion during lactation. Furthermore, AVP can directly initiate milk ejection similar to oxytocin by interacting with both vasopressin and oxytocin receptors located in myoepithelial cells of the mammary gland...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134985/effects-of-unripe-musa-paradisiaca-on-the-histochemistry-of-the-testis-and-testosterone-levels-in-adult-albino-rats
#18
A S Alabi, G O Omotosho, C N B Tagoe, O B Akinola, B U Enaibe
This study was aimed at determining the effects of the unripe fruit of Musa paradisiaca on the testis andtestosterone levels in male Wistar rats. The animals were grouped into three, comprising a control, and 2 treatment groupsadministered with different doses (500 mg/kg and 1000 mg/kg) daily of the fruit flour over 28 days. Histochemical evaluationof the testes was done using Haematoxylin and Eosin, Periodic acid Schiff's (PAS) and Feulgen staining techniques, whilethe serum and homogenised testicular tissue were evaluated for testosterone levels using Accu-Bind ELISA Kit...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134984/evaluation-of-neuroprotective-effect-of-hibiscus-sabdariffa-linn-aqueous-extract-against-ischaemic-reperfusion-insult-by-bilateral-common-carotid-artery-occlusion-in-adult-male-rats
#19
Olatunde Owoeye, Micheal Oluwatosin Gabriel
Ischaemic brain injury continues to be devastating, causing social, medical and relationship disruption. Oxidativedamage has been reported to be one of the mechanisms for brain damage following ischaemic stroke. The antioxidant activityof Hibiscus sabdariffa L. was investigated for a possible protective effect against ischaemia-induced brain damage in rats.Adult male Wistar rats (n=35) were divided into five groups of 7 rats per group. Group 1 served as control was given tapwater; Group 2: 500 mg/kg daily of Hibiscus sabdariffa L...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134983/anti-hyperglycaemic-effects-of-rutin-on-blood-glucose-oxidative-stress-biomarkers-and-lipid-peroxidation-in-alloxan-induced-hyperglycaemic-wistar-rats
#20
Y Tanko, A I Salisu, K A Mohammed, S A Musa, A Jimoh, R Yusuf
The present study investigated the anti-hyperglycaemic effect of rutin on blood glucose, oxidative stressbiomarkers and lipid peroxidation in alloxan induced hyperglycaemic wistar rats. Diabetes was induced in rats by anintraperitoneal (i.p) injection of alloxan monohydrate 150 mg/kg body weight. Twenty five wistar rats were divided asfollows; Group1 served as diabetic control received distilled water 2 mg/kg, Group served as positive control received 2mg/kg glibenclamide, 3, 4 and 5 received rutin at 50, 100 and 200 mg/kg body weight for 28 days respectively...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
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