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Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria

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https://www.readbyqxmd.com/read/28262857/a-review-on-the-possible-neuroprotective-effects-of-moringa-oleifera-leaf-extract
#1
REVIEW
O O Igado, J K Olopade
Moringa oleifera is an edible plant that has been reputed to be a miracle plant by numerous authors, with effects on practically every body system. Phytochemical analyses have demonstrated that the leaves are rich in various minerals, vitamins and antioxidants. Its use in some continents dates back to Antiquity. Neurodegeneration are chronic diseases of the nervous system. There is currently an increase in the use of natural products to combat these debilitating diseases. So far, no suitable cure has been found, and conditions are managed and the symptoms treated...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28262856/resting-serum-concentration-of-high-sensitivity-c-reactive-protein-hs-crp-in-sportsmen-and-untrained-male-adults
#2
COMPARATIVE STUDY
F A Niyi-Odumosu, O A Bello, S A Biliaminu, B V Owoyele, T O Abu, O L Dominic
There is an inverse relationship between regular physical activity and concentration of serum inflammatory markers, with variations in resting CRP in trained and untrained subjects. The effect of acute and prolonged exercises has been studied on inflammatory markers with dearth of information and controversies on the resting serum values of high sensitivity CRP (hs-CRP). Therefore, this study sought to identify and compare variations that occur in serum levels of high sensitivity CRP in groups of sportsmen (6) and physically active untrained subjects...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28262855/studies-on-zinc-and-copper-ion-in-relation-to-wound-healing-in-male-and-female-west-african-dwarf-goats
#3
COMPARATIVE STUDY
A K Olaifa, S T Fadason
Wound healing remains a challenging clinical problem for which precise and efficient management is essential in order to curtail morbidity and mortality. Wound healing has been shown to depend upon the availability of appropriate trace elements like copper and zinc which serve as enzyme cofactors and structural components in tissue repair. This study aims at evaluating the distribution of zinc and copper found in the hair as well as skin during epidermal wound healing. Adult and healthy West African dwarf (WAD) goats of both sexes fed with concentrate, grass, cassava peel and water ad libitum were used...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28262854/effect-of-insulin-on-visuo-spatial-memory-and-histology-of-cerebral-cortex-in-the-presence-or-absence-of-nitric-oxide-inhibition
#4
I U Yarube, J O Ayo, M Y Fatihu, R A Magaji, I A Umar, A W Alhassan, M Ia Saleh
Insulin has emerged from its traditional 'peripheral' glucose-lowering function to become increasingly regarded as a brain hormone that controls a wide range of functions including learning and memory. Insulin action on learning and memory is linked to nitric oxide (NO) signalling, but its effects on memory and histology of cerebral cortex in conditions of varied NO availability is unclear. This research sought to determine the effect of insulin on visuo-spatial learning, memory and histology of cerebral cortex during NO deficiency...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28262853/effect-of-low-dose-lead-pb-administration-on-tail-immersion-test-and-formalin-induced-pain-in-wistar-rats-possible-modulatory-role-of-cobalt-ii-chloride
#5
A H Umar, I Suleiman, H Muhammed
Lead (Pb) is cheap and there is a long tradition of its use, but its toxic effects have also been recognized. There is increased public health concern regarding the hazards of low dose Pb exposure to adults and children. Studies have shown the risks for hypertension, decrements in renal function, subtle decline in cognitive function, and adverse reproductive outcome at low blood Pb level. In this study, the possible modulatory role of cobalt (II) chloride (CoCl2) on low level Pb exposure on tail immersion test and formalin induced pain was investigated...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28262852/repeated-acute-oral-exposure-to-cannabis-sativa-impaired-neurocognitive-behaviours-and-cortico-hippocampal-architectonics-in-wistar-rats
#6
A Imam, M S Ajao, O B Akinola, M I Ajibola, A Ibrahim, A Amin, W I Abdulmajeed, Z A Lawal, A Ali-Oluwafuyi
The most abused illicit drug in both the developing and the developed world is Cannabis disposing users to varying forms of personality disorders. However, the effects of cannabis on cortico-hippocampal architecture and cognitive behaviours still remain elusive.  The present study investigated the neuro-cognitive implications of oral cannabis use in rats. Eighteen adult Wistar rats were randomly grouped to three. Saline was administered to the control rats, cannabis (20 mg/kg) to the experimental group I, while Scopolamine (1 mg/kg...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28262851/effects-of-selenium-yeast-on-blood-glucose-and-antioxidant-biomarkers-in-cholesterol-fed-diet-induced-type-2-diabetes-mellitus-in-wistar-rats
#7
Y Tanko, A Jimoh, A Ahmed, A Adam, L Ejeh, A Mohammed, J O Ayo
Selenium is an antioxidant that prevents oxygen radical from damaging cells from chronic diseases that can develop from cell injury and inflammation such as diabetes mellitus. The aim of the study is to investigate the possible protective effect of selenium yeast on cholesterol diet induced type-2 diabetes mellitus and oxidative stress in rats. Twenty male wistar rats were divided in to four groups of five animals each: Group 1: (Negative control) received standard animal feed only, Group 2:  received cholesterol diet (CD) only, Group 3: received CD and 0...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28262850/effects-of-petrol-exposure-on-glucose-liver-and-muscle-glycogen-levels-in-the-common-african-toad-bufo-regularis
#8
G O Isehunwa, I O Yusuf, A Ar Alada
This study investigated the effects of exposure to petrol on blood glucose, liver and muscle glycogen levels in the common African toad Bufo regularis. A total of 126 adult toads of either sex weighing between 70-100g were used for this study. The experiment was divided into three phases. The phase 1 experiment the acute toxicity test consisted of animals divided into six groups of 10 toads per group and were exposed to water (H2O), H2O + Tween 80, 2ml/l, 3ml/l, 5ml/l, and 10ml/l of petrol respectively for 96 hours using the static renewal bioassay system...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28262849/morphological-characterization-of-the-african-giant-rat-cricetomys-gambianus-waterhouse-brain-across-age-groups-gross-features-of-cortices
#9
COMPARATIVE STUDY
M A Olude, O A Mustapha, J K Olopade
This experiment was designed to investigate the morphological characterization of the brain cortices of African giant rats, AGR (Cricetomys gambianus, Waterhouse) across age groups as related to function. A total of 15 male AGR were used for this study comprising of 5 neonates, 5 juveniles and 5 adults. Brains were described as having typical rodent features; the falx cerebri, the dura modification of interest, was partly inserted between the lobes of the olfactory bulb and extended towards the corpus callosum...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28262848/neuronal-function-in-male-sprague-dawley-rats-during-normal-ageing
#10
COMPARATIVE STUDY
A J Idowu, I I Olatunji-Bello, J A Olagunju
During normal ageing, there are physiological changes especially in high energy demanding tissues including the brain and skeletal muscles. Ageing may disrupt homeostasis and allow tissue vulnerability to disease. To establish an appropriate animal model which is readily available and will be useful to test therapeutic strategies during normal ageing, we applied behavioral approaches to study age-related changes in memory and motor function as a basis for neuronal function in ageing in male Sprague Dawley rats...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28262847/iron-status-of-pregnant-women-in-rural-and-urban-communities-of-cross-river-state-south-south-nigeria
#11
MULTICENTER STUDY
I M Okafor, D C Okpokam, A B Antai, E A Usanga
Anaemia in pregnancy is a major public health problem in Nigeria. Iron deficiency is one of the major causes of anaemia in pregnancy.  Inadequate iron intake during pregnancy can be dangerous to both baby and mother. Iron status of pregnant women was assessed in two rural and one urban communities in Cross River State Nigeria. Packed cell volume, haemoglobin, mean cell haemoglobin, mean cell haemoglobin concentration, red cell count, serum iron, total iron binding capacity, transferrin saturation, serum ferritin, soluble transferrin receptor and soluble transferrin receptor/ferritin ratio were measured in plasma/serum of 170 pregnant women within the age range of 15-45 years...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28262846/antiseizure-effects-of-ketogenic-diet-on-seizures-induced-with-pentylenetetrazole-4-aminopyridine-and-strychnine-in-wistar-rats
#12
E O Sanya, A O Soladoye, O O Desalu, P M Kolo, L A Olatunji, J K Olarinoye
The ketogenic diet (KD) is a cheap and effective alternative therapy for most epilepsy. There are paucity of experimental data in Nigeria on the usefulness of KD in epilepsy models. This is likely to be responsible for the poor clinical acceptability of the diet in the country. This study therefore aimed at providing experimental data on usefulness of KD on seizure models.  The study used 64 Wistar rats that were divided into two dietary groups [normal diet (ND) and ketogenic diet (KD)]. Animal in each group were fed for 35days...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28262845/neurobehavioral-deficits-in-progressive-experimental-hydrocephalus-in-neonatal-rats
#13
F E Olopade, M T Shokunbi
Hydrocephalus is usually associated with functional deficits which can be assessed by neurobehavioral tests. This study characterizes the neurobehavioral deficits occurring with increasing duration and severity of ventriculomegaly in an experimental neonatal hydrocephalic rat model. Hydrocephalus was induced in three weeks old albino rats by intracisternal injection of kaolin while controls received sterile water injection. They were sacrificed in batches at one, four and eight weeks post-injection after neurobehavioral tests (forelimb grip strength, open field and Morris water maze tests) were performed...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574771/serum-levels-of-selected-vitamins-and-trace-elements-in-nigerian-consumers-of-alcoholic-beverage-a-suggestion-for-dna-hypomethylation
#14
A N Ude, V F Edem, A A Onifade, O G Arinola
Folic acid, vitamins and Zinc play essential role in DNA methylation but alcohol consumption is known to affectthe levels of these micronutrients leading to risk of developing various illnesses and certain cancers. This study determinedthe levels of DNA methylation dependent-micronutrients (folate, vitamin B12, vitamin B6, zinc and selenium) andhomocysteine as a suggestion for DNA methylation status in Nigerian alcohol consumers compared with non-consumers ofalcohol. Venous blood (5ml) was obtained from thirty-four males that consume alcoholic beverages for at least 10 years andthirty-two male controls that did not consume alcoholic beverages at least 10 years...
August 30, 2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574770/antidepressant-like-potentials-of-buchholzia-coriacea-seed-extract-involvement-of-monoaminergic-and-cholinergic-systems-and-neuronal-density-in-the-hippocampus-of-adult-mice
#15
S A Onasanwo, S O Faborode, K O Ilenre
Buchholzia coriacea, taken by elderly, has phytochemicals that have neuro-active metabolites, and the folkloredocumented its use in neuro-behavioral despairs. Previous study in our laboratory shows that methanol extracts of Buchholziacoriacea (MEBC) seeds possess antidepressant-like potentials in laboratory rodents. This present study was conducted toinvestigate the probable mechanism(s) of action by which MEBC potentiates its effects using laboratory rodents.Involvements of serotonergic, cholinergic and adrenergic systems were studied using Forced Swimming Test (FST) and TailSuspension Test (TST) models of behavioral despair...
August 30, 2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574769/conception-of-pharmacological-knowledge-and-needs-amongst-nigerian-medical-students-at-lagos-state-university-college-of-medicine-implication-for-future-biomedical-science-in-africa
#16
Luther Agbonyegbeni Agaga, Theresa Adebola John
In Nigeria, medical students are trained in more didactic environments than their counterparts in researchintensive academic medical centers. Their conception of pharmacology was thus sought. Students who are taking/have takenthe medical pharmacology course completed an 18-question survey within 10min by marking one/more choices fromalternatives. Instructions were: "Dear Participant, Please treat as confidential, give your true view, avoid influences, avoidcrosstalk, return survey promptly." Out of 301 students, 188 (62...
August 30, 2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574768/evaluation-of-body-mass-index-and-plasma-lipid-profile-in-boerboel-dogs
#17
Rasheed Adetola Ajadi, Rashidat Oluwatobiloba Ashogbon, Abisola Abosede Adeniyi
This study evaluated the body mass index (BMI) and plasma lipid profile in Boerboel dogs. Body weights (BW),height (H) at shoulder and waist circumference (WC) were obtained from fifty-three Boerboels to determine the BMI while,body condition score (BCS) was determined subjectively. Also 5mls of blood was obtained from the dogs for determinationof total cholesterol (TC), triglycerides (TRIG), low density lipoproteins (LDL) and high density lipoproteins (HDL). Datawere presented as means ± standard deviation and results were compared using analysis of variance...
August 30, 2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574767/resveratrol-protects-rabbits-against-cholesterol-diet-induced-hyperlipidaemia
#18
Y Tanko, A Jimoh, A Ahmed, A Mohammed, J O Ayo
The excessive consumption of high cholesterol diet has been associated with an increased incidence oflipidaemia. Lipidaemia is enhanced by formation of oxidative stress, lipid peroxidation and hyperglycaemia. The aim ofthese experiments was to investigate the protective effect of resveratrol co-administered with cholesterol diet inducedhyperlipidaemia in rabbits. Thirty rabbits divided into six groups of five animal (group= 5) each: group 1 = normal control,group 2 = cholesterol diet/high fat diet group only (HFD), group 3 = resveratrol 200 mg/kg (R200), group 4 = resveratrol400 mg/kg (R400), group 5 = HFD + R200 and group 6 = HFD + R400...
August 30, 2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574766/sports-participation-anthropometric-and-physiological-profiles-of-university-athletes
#19
M O Moses, B M Duduyemi
Sports participation has been adjudged to enhance healthy living. This study described anthropometric andphysiological (A-P) profiles of university athletes based on types of sports (ToS) and duration (in years) of participation(DoP). One hundred and twenty-nine athletes (69 males, 60 females), aged l5-36, who had played averagely for5.78±0.29years, from nine games and preparing for Ghana University Sports Association (GUSA) 2014 participated in thestudy. Ex-post facto research design was adopted. Data on ToS, DoP, age, height, weight, body mass index, waist and hipcircumference, body fat and water, blood pressure and heart rate were collected, entered into SPSS Data Editor 17...
August 30, 2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27574765/effect-of-vitamin-c-supplementation-on-platelet-aggregation-and-serum-electrolytes-levels-in-streptozotocin-induced-diabetes-mellitus-in-rats
#20
Daniel U Owu, Chukwuemeka R Nwokocha, Daniel E Ikpi, Emmanuel I Ogar
Diabetes mellitus (DM) is a disease condition characterised by hyperglycemia; free radical and abnormalhaematological indices. Vitamin C can reduce free radical generation and ameliorate adverse conditions of diabetes mellitus.The aim of the present study is to investigate the effect of vitamin C on platelet aggregation and electrolyte levels in Type 1DM. Male Wistar rats were divided into four groups namely control, DM, DM +Vitamin C and Vitamin C groups. Rats weremade diabetic with a single dose of streptozotocin (65 mg/kg) intraperitoneally...
August 30, 2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
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