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Molecular Carcinogenesis

Chunyan Liu, Junyi Tang, Chang Li, Guangbo Pu, Dongxia Yang, Xiaotian Chang
An increasing amount of evidence indicates that peptidylarginine deiminase isoform 4 (PADI4) plays an important role in tumorigenesis. However, the effects of PADI4 on tumor-bearing mice are unknown, and no studies have investigated this tumorigenic pathway in an animal model. In the present study, ECA109 cells originating from esophageal squamous cell carcinoma (ESCC) were transfected with PADI4-expressing lentivirus and were injected into BALB/c nude mice. Tumor size and weight were significantly increased in the mouse tumors established with PADI4-overexpressing ECA109 cells...
September 22, 2018: Molecular Carcinogenesis
Yangyang Feng, Yue Gao, Juanhan Yu, Guiyang Jiang, Xiupeng Zhang, Xuyong Lin, Qiang Han, Xuezhu Rong, Hongtao Xu, Qingchang Li, Xueshan Qiu, Enhua Wang
Coiled-coil domain containing 85 B (CCDC85B) is involved in diverse biological processes; however, its expression patterns and functions in human cancers are yet unknown. The present study demonstrated that the expression of CCDC85B in the cytoplasm of the non-small cell lung cancer (NSCLC) tumor cells was significantly higher compared to adjacent normal lung tissues (P < 0.05). Furthermore, CCDC85B expression correlated with advanced TNM stage (P = 0.004) and positive regional lymph node metastasis (P = 0...
September 22, 2018: Molecular Carcinogenesis
Sushma Yadav, Claudia M Kowolik, Min Lin, Darren Zuro, Susanta K Hui, Arthur D Riggs, David A Horne
Prostate cancer is one of the most commonly diagnosed cancers and a pressing health challenge in men worldwide. Radiation therapy (RT) is widely considered a standard therapy advanced as well as localised prostate cancer. Although this primary therapy is associated with high cancer control rates, up to one third of patients undergoing radiation therapy becomes radio-resistant and/or has tumor-relapse/recurrence. Therefore, focus on new molecular targets and pathways is essential to develop novel radio-sensitizing agents for the effective and safe treatment of prostate cancer...
September 22, 2018: Molecular Carcinogenesis
Andressa Duarte, Gwennan André-Grégoire, Kilian Trillet, An Thys, Nicolas Bidère, Alfredo Ribeiro-Silva, Julie Gavard
Head and neck squamous cell carcinoma (HNSCC) represent aggressive classes of tumors with a high mortality rate. The mammalian target of rapamycin (mTOR) pathway is instrumental in their initiation and expansion. Although results from pre-clinical models promise mTOR targeting as a potent novel therapeutic approach, its impact on the tumor microenvironment, such as endothelial cells is only scarcely investigated. Here, we first confirmed the effects of mTOR pharmacological inhibition on cell viability, clonogenicity, and proliferation in HNSCC human cell lines, HN26 and HN30...
September 19, 2018: Molecular Carcinogenesis
Carolina Velázquez, Eva M Esteban-Cardeñosa, Enrique Lastra, Luis E Abella, Virginia de la Cruz, Carmen D Lobatón, Mercedes Durán, Mar Infante
BRIP1 is a component of the Fanconi Anemia/BRCA pathway responsible for DNA reparation via helicase activity. Some heterozygous variants in BRIP1 could contribute to Hereditary Breast Cancer through a defective DNA repair. The clinical utility of BRIP1 mutations in a familial cancer context is compromised by the conflicting interpretation of "variants of uncertain significance" (VUS). Defining the clinical significance of variants identified in genetic tests is a major challenge; therefore, studies that evaluate the biological effect of these variants are definitely necessary...
September 19, 2018: Molecular Carcinogenesis
Jui-Chieh Chen, Cheng Huang, I-Neng Lee, Yu-Ping Wu, Chih-Hsin Tang
Chondrosarcoma is characterized by the ability to produce extracellular matrix of cartilage. Curative surgical resection becomes difficult when high-grade chondrosarcoma metastasizes to other parts of the body. Doxorubicin (Dox) has been widely used clinically to treat many different types of cancers, including chondrosarcomas. However, chondrosarcoma is often resistant to chemotherapy and radiotherapy. New systemic treatment regimens are needed to improve the prognosis. Amphiregulin (AR) has been reported to be involved in cancer metastasis and drug resistance...
September 19, 2018: Molecular Carcinogenesis
Ji-Hong Song, Cheol-Jung Lee, Hyun-Jung An, Sun-Mi Yoo, Han C Kang, Joo Y Lee, Kwang D Kim, Dae J Kim, Hye S Lee, Yong-Yeon Cho
Ras/Raf/MEKs/ERKs and PI3 K/Akt/mTOR signaling pathways have key roles in cancer development and growth processes, as well as in cancer malignance and chemoresistance. In this study, we screened the therapeutic potential of magnolin using 15 human cancer cell lines and combined magnolin sensitivity with the CCLE mutaome analysis for relevant mutation information. The results showed that magnolin efficacy on cell proliferation inhibition were lower in TOV-112D ovarian cancer cells than that in SKOV3 cells by G1 and G2/M cell cycle phase accumulation...
September 19, 2018: Molecular Carcinogenesis
Mei-Xia Zhang, Wei Gan, Chu-Yu Jing, Su-Su Zheng, Yong Yi, Juan Zhang, Xin Xu, Jia-Jia Lin, Bo-Heng Zhang, Shuang-Jian Qiu
S100A11 is reported to associate with progression and poor prognosis in several tumors. We previously reported that S100A11 was highly expressed in intrahepatic cholangiocarcinoma (ICC) cells and promoted TGF-β1-induced EMT through SMAD2/3 signaling pathway. Here, we explored the prognostic role of S100A11 on ICC patients and preliminary molecular mechanisms how S100A11 regulated ICC cell proliferation. Our results showed that S100A11 was obviously increased in ICC tumor tissues. High expression of S100A11 was closely correlated with lymph node metastasis (LNM) and TNM stage and was an independent risk factor for patients' overall survival (OS) and recurrence-free survival (RFS)...
September 4, 2018: Molecular Carcinogenesis
Tao Hu, Jingyang Zhang, Beibei Sha, Miaomiao Li, Longhao Wang, Yi Zhang, Xingge Liu, Ziming Dong, Zhenzhen Liu, Pei Li, Ping Chen
Increasing evidence suggests that deubiquitinase USP7 participates in tumor progression by various mechanisms and serves as a potential therapeutic target. However, its expression and role in esophageal cancer remains elusive; the anti-cancer effect by targeting USP7 still needs to be investigated. Here, we reported that USP7 was overexpressed in esophageal squamous cell carcinoma (ESCC) tissues compared with adjacent tissues, implying that USP7 was an attractive anticancer target of ESCC. Pharmaceutical or genetic inactivation of USP7 inhibited esophageal cancer cells growth in vitro and in vivo and induced apoptosis...
September 4, 2018: Molecular Carcinogenesis
Zhenpeng Qiu, Cong Zhang, Junxuan Zhou, Junjie Hu, Lei Sheng, Xin Li, Liang Chen, Xiang Li, Xukun Deng, Guohua Zheng
Previous studies have demonstrated that the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib shows efficacy against multiple cancers, including hepatocellular carcinoma. However, whether celecoxib is effective in alleviating steatosis during hepatocarcinogenesis is unknown. In a rapid hepatocellular carcinoma (HCC) mouse model established via hydrodynamic transfection of activated forms of AKT and c-Met proto-oncogenes, we investigated the antisteatotic and anticarcinogenic efficacy of celecoxib in vivo...
September 4, 2018: Molecular Carcinogenesis
Gang Yuan, Tingjia Chen, Haiqing Zhang, Qinghua Cao, Yun Qiu, Biao Que, Sui Peng, Minhu Chen, Weidong Ji
Circular RNAs (circRNAs) have received increasing attention for their involvement in the pathogenesis of cancer; however, the characterization and function of circRNAs in colitis-induced colon carcinoma remains largely unknown. A colitis-induced colon carcinoma model was established in mice treated with azoxymethane-dextran sodium sulfate (AOM-DSS), and the circRNA profile was screened by next generation sequencing. Bioinformatic tools, including Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and network analysis were used to predict the functions of differentially expressed circRNAs and potentially coexpressed target genes...
September 4, 2018: Molecular Carcinogenesis
Yi Zhang, Beifang Yang, Xiang Cheng, Li Liu, Ying Zhu, Yajie Gong, Yang Yang, Jianbo Tian, Xiating Peng, Danyi Zou, Lan Yang, Shufang Mei, Xiaoyang Wang, Jiao Lou, Juntao Ke, Jiaoyuan Li, Jing Gong, Jiang Chang, Peng Yuan, Rong Zhong
Despite the successes of genome-wide association study (GWAS) in identifying breast cancer (BC) risk-associated variants, only a small fraction of the heritability can be explained. The greatest challenge in the post-GWAS is to identify causal variants and underlying mechanisms responsible for BC susceptibility. In this study, we integrated functional genomic data from ENCODE ChIP-seq, ANNOVAR, and the TRANSFAC matrix to identify potentially regulatory variants with modulating FOXA1-binding affinity across the whole genome, and then conducted a two-stage case-control study including 2164 cases and 2382 controls to investigate the associations between candidate SNPs and BC susceptibility...
September 4, 2018: Molecular Carcinogenesis
Zi-Qi Zhou, Jing-Jing Zhao, Chang-Long Chen, Yuan Liu, Jian-Xiong Zeng, Zheng-Rong Wu, Yan Tang, Qian Zhu, De-Sheng Weng, Jian-Chuan Xia
The HUS1 checkpoint clamp component (HUS1), which is a member of an evolutionarily conserved, genotoxin-activated checkpoint complex (Rad9-Rad1-Hus1 [9-1-1] complex), is involved in cell cycle arrest and DNA repair in response to DNA damage. We conducted this study to investigate the biological significances of HUS1 expression in hepatocellular carcinoma (HCC) development. The mRNA and protein expression levels of HUS1 were determined using Real-time PCR and Western blot, respectively. One hundered and twenty four paraffin sections from HCC tissues were analyzed by immunohistochemistry to assess the association between HUS1 expression and clinicopathological characteristics of patients...
September 4, 2018: Molecular Carcinogenesis
Ze-Bin Jiang, Bing-Qiang Ma, Shao-Guang Liu, Jing Li, Guang-Ming Yang, Ya-Bo Hou, Ruo-Huang Si, Peng Gao, Hui-Ting Yan
Liver cancer stem cells (CSCs) were involved in tumorigenesis, progression, recurrence and drug resistance of hepatocellular carcinoma (HCC). miR-365 was downregulated in hepatocellular carcinoma and inhibited HCC cell proliferation and invasion. However, the role of miR-365 in liver cancer stem cells was unknown. Herein, we observed a remarkable decrease of miR-365 expression in CD133 or EpCAM-positive liver CSCs as well as in CSC-enriched hepatoma spheres. Up-regulated miR-365 suppressed liver CSC expansion by inhibiting the dedifferentiation of hepatoma cells and decreasing the self-renewal ability of liver CSCs...
September 4, 2018: Molecular Carcinogenesis
Pan Jiang, Chuyue Xu, Lijun Chen, Aochang Chen, Xiaoyue Wu, Ming Zhou, Ijaz Ul Haq, Zahula Mariyam, Qing Feng
Non-small cell lung cancer (NSCLC) remains one of the most aggressive tumors with low life expectancy worldwide. The existence of cancer stem cells (CSCs) contributes to the failure of cancer treatment resulted from drug resistance. Altered microRNA expression has been observed in human tumors due to its role in tumor growth, progression, and metastasis. Hence, the aim of our present study was to investigate the effects of miR-485 on the CSC-like traits in NSCLC A549-cisplatin resistant cells and concentrate on the underlying molecular mechanism...
September 4, 2018: Molecular Carcinogenesis
Yunxiao Liu, Yanyan Dong, Liping Zhao, Lihong Su, Kexin Diao, Xiaoyi Mi
TRIM59 has been recently implicated in the carcinogenesis of several cancers such as lung cancer, gastric cancer, and bladder cancer. However, its expression pattern and clinical significance has not been investigated in human breast cancer. In the present study, we examined TRIM59 protein expression in 95 cases of breast cancer tissues using immunohistochemistry. We found that TRIM59 was upregulated in 42 out of 95 cases and correlated with TNM stage (P = 0.0056), lymph node metastasis (P = 0.0088) and poor prognosis (P = 0...
September 3, 2018: Molecular Carcinogenesis
Xinmiao Yu, Minghao Wang, Qiang Han, Xiupeng Zhang, Xiaoyun Mao, Xu Wang, Xiaoying Li, Wei Ma, Feng Jin
The biological role and underlying mechanism of action of zinc-finger protein 326 (ZNF326) in malignant tumors, including breast cancer, are still not clear. In this study, we detected high expression of ZNF326 in breast cancer specimens (60/111, 54.1%) and breast cancer cell lines (7/7); the expression level of ZNF326 was inversely associated with advanced pTNM stage (P = 0.002), positive lymph node metastasis (P = 0.004), poor prognosis in patients with breast cancer (P = 0.0097), and ER/PR/Her2 status (P = 0...
September 3, 2018: Molecular Carcinogenesis
Yi Pan, Joanna H M Tong, Wei Kang, Raymond W M Lung, Wing Po Chak, Lau Ying Chung, Feng Wu, Hui Li, Jun Yu, Anthony W H Chan, Ka Fai To
Colorectal cancer (CRC) is a heterogeneous disease with complex mechanisms of pathogenesis. Classification systems have been proposed based on molecular features of tumors in clinical practice. Thus, more molecular markers associated with development and progression of CRC might serve as useful tools for early diagnosis even for providing more accurate molecular classification. Frequent gain of chromosome 8q was detected in CRC by array-CGH and overexpression of exosome component 4 (EXOSC4) in this region was revealed by expression microarray analysis...
August 29, 2018: Molecular Carcinogenesis
Yuejin Li, Kunyu Ju, Weiwei Wang, Zheliang Liu, Haitao Xie, Yuan Jiang, Guanmin Jiang, Jinping Lu, Zigang Dong, Faqing Tang
Nasopharyngeal carcinoma (NPC) has a high metastatic clinicopathological feature. As a carcinogen factor, N,N'-dinitrosopiperazine (DNP) is involved in NPC metastasis, but its precise mechanism has not been fully elucidated. Herein, we showed that DNP promotes NPC metastasis through upregulating miR-149. DNP was found to decrease Plakophilin3 (PKP3) expression, further DNP-decreased PKP3 was verified to be through upregulating miR-149. We also found that DNP induced proliferation, adhesion, migration and invasion of NPC cell, which was inhibited by miR-149-inhibitor...
August 25, 2018: Molecular Carcinogenesis
Jyotsana Singhal, Shireen Chikara, David Horne, Ravi Salgia, Sanjay Awasthi, Sharad S Singhal
Consumption of citrus-fruits is associated with reduced incidence of breast cancer (BC), the most common cancer diagnosed in women across the globe. In this study, we investigated the anticancer potential of 2-Hydroxyflavanone (2HF) in BC. 2HF, a citrus-bioflavonoid, has demonstrated anticancer properties in various cancers, but its anticancer role in BC has not been well studied. We investigated the in vitro and in vivo growth inhibitory effects of 2HF in an array of BC lines and in xenograft mouse models of ER-positive and HER2-positive BC cells...
August 22, 2018: Molecular Carcinogenesis
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