journal
MENU ▼
Read by QxMD icon Read
search

Current Opinion in Infectious Diseases

journal
https://www.readbyqxmd.com/read/27922853/heart-sink-topics-in-sexually-transmitted-infections-vaccinations-anal-cancer-screening-and-overlapping-infection-epidemics-in-eastern-europe
#1
Karen E Rogstad
No abstract text is available yet for this article.
December 2, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27922852/hiv-associated-changes-in-the-enteric-microbial-community-potential-role-in-loss-of-homeostasis-and-development-of-systemic-inflammation
#2
David B Gootenberg, Jeffrey M Paer, Jesus-Mario Luevano, Douglas S Kwon
PURPOSE OF REVIEW: Despite HIV therapy advances, average life expectancy in HIV-infected individuals on effective treatment is significantly decreased relative to uninfected persons, largely because of increased incidence of inflammation-related diseases, such as cardiovascular disease and renal dysfunction. The enteric microbial community could potentially cause this inflammation, as HIV-driven destruction of gastrointestinal CD4 T cells may disturb the microbiota-mucosal immune system balance, disrupting the stable gut microbiome and leading to further deleterious host outcomes...
December 2, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27922851/future-prospects-for-new-vaccines-against-sexually-transmitted-infections
#3
Sami L Gottlieb, Christine Johnston
PURPOSE OF REVIEW: This review provides an update on the need, development status, and important next steps for advancing development of vaccines against sexually transmitted infections (STIs), including herpes simplex virus (HSV), Neisseria gonorrhoeae (gonorrhea), Chlamydia trachomatis (chlamydia), and Treponema pallidum (syphilis). RECENT FINDINGS: Global estimates suggest that more than a million STIs are acquired every day, and many new and emerging challenges to STI control highlight the critical need for development of new STI vaccines...
December 2, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27870645/where-next-with-preexposure-prophylaxis
#4
Diarmuid Nugent, Richard Gilson
PURPOSE OF REVIEW: Controlling the HIV epidemic remains a major public health challenge, and there is an urgent need for novel prevention strategies. Preexposure prophylaxis (PrEP) refers to the use of antiretrovirals in HIV-negative people at high risk to prevent infection and has the potential to be an important component in the global effort to end the HIV epidemic by 2030. We review the current evidence for the safety and efficacy of PrEP in its different forms and address emergent issues and concerns regarding its implementation...
November 18, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27828809/epidemiology-diagnosis-and-treatment-of-brain-abscesses
#5
Matthijs C Brouwer, Diederik van de Beek
PURPOSE OF REVIEW: This article describes the epidemiology, diagnosis, and treatment of brain abscesses focusing on studies published in the past 2 years. RECENT FINDINGS: In the recent literature, advances have been made in describing the disease, ancillary investigations, and treatment, mostly by combining previously available literature in meta-analyses. These studies identified Staphylococcus and Streptococcus species as the most frequent cause of brain abscess...
November 18, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27849636/the-potential-role-of-wolbachia-in-controlling-the-transmission-of-emerging-human-arboviral-infections
#6
Joseph Kamtchum-Tatuene, Benjamin L Makepeace, Laura Benjamin, Matthew Baylis, Tom Solomon
PURPOSE OF REVIEW: Wolbachia is a genus of Gram-negative intracellular bacteria that is naturally found in more than half of all arthropod species. These bacteria cannot only reduce the fitness and the reproductive capacities of arthropod vectors, but also increase their resistance to arthropod-borne viruses (arboviruses). This article reviews the evidence supporting a Wolbachia-based strategy for controlling the transmission of dengue and other arboviral infections. RECENT FINDINGS: Studies conducted 1 year after the field release of Wolbachia-infected mosquitoes in Australia have demonstrated the suppression of dengue virus (DENV) replication in and dissemination by mosquitoes...
November 15, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27849635/new-initiatives-to-develop-self-testing-for-hiv
#7
T Charles Witzel, Alison J Rodger
PURPOSE OF REVIEW: The purpose is to describe the most recent literature associated with HIV self-testing (HIVST). RECENT FINDINGS: HIVST is acceptable to a range of populations in a variety of contexts, particularly if users' values and preferences are taken into account in intervention development. Approaches being explored in ongoing and planned studies are the efficacy of HIVST to increase diagnosis of long-standing prevalent infections and to reduce the interval between HIV transmission and diagnosis, particularly in high-incidence groups...
November 15, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27845953/facing-new-challenges-to-promote-long-term-health-for-people-living-with-hiv
#8
David H Dockrell
No abstract text is available yet for this article.
November 10, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27845952/human-papillomavirus-as-a-cause-of-anal-cancer-and-the-role-of-screening
#9
Karien C M Gosens, Olivier Richel, Jan M Prins
PURPOSE OF REVIEW: Anal cancer is a serious health problem in HIV-positive men who have sex with men, and precursor lesions, anal intraepithelial neoplasia, are well defined. Given the similarities with cervical cancer, screening for and treatment of anal intraepithelial neoplasia might prevent anal cancer. Screening programmes should meet the Wilson and Jungner criteria. We used these criteria to evaluate the current body of evidence supporting a screening programme for anal dysplasia...
November 10, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27828810/community-acquired-bacterial-meningitis
#10
Joost M Costerus, Matthijs C Brouwer, Merijn W Bijlsma, Diederik van de Beek
PURPOSE OF REVIEW: Bacterial meningitis is a medical emergency and is associated with a high disease burden. We reviewed recent progress in the management of patients with community-acquired bacterial meningitis. RECENT FINDINGS: The worldwide burden of disease of bacterial meningitis remains high, despite the decreasing incidence following introduction of routine vaccination campaigns. Delay in diagnosis and treatment remain major concerns in the management of acute bacterial meningitis...
November 8, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27828808/managing-chronic-kidney-disease-in-the-older-adults-living-with-hiv
#11
Frank A Post
PURPOSE OF REVIEW: HIV replication and immunodeficiency are important risk factors for chronic kidney disease (CKD). Widespread use of antiretrovirals that may affect kidney function underscores the need for monitoring kidney function, allowing early detection of drug-induced kidney injury and identification of patients who may benefit from antiretroviral therapy switches. RECENT FINDINGS: Several cohorts have reported an increased incidence of CKD with tenofovir [tenofovir disoproxil fumarate (TDF)], atazanavir, and lopinavir, and CKD risk scores have been developed to identify those most at risk of kidney disease progression while receiving these agents...
November 8, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27820708/lyme-neuroborreliosis
#12
Uwe Koedel, Hans-Walter Pfister
PURPOSE OF REVIEW: Lyme disease is a multistage and multisystem disease. Neurological manifestations [termed Lyme neuroborreliosis (LNB)] occur in about 10% of patients with Lyme disease. Diagnostics and treatment of early and late LNB are widely established. However, the management of persistent symptoms is still fraught with controversies, and therefore is the focus of this review. RECENT FINDINGS: The incidence of Lyme disease seems to be much higher than previously assumed...
November 4, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27798498/hiv-associated-neurocognitive-disorder
#13
David B Clifford
PURPOSE OF REVIEW: HIV-associated neurocognitive disease is the most active topic for neuroAIDS investigations at present. Although impairment is mild in patients successfully treated with modern antiviral regimens, it remains an ongoing problem for HIV patients. It is important to update the emerging research concerning HIV-associated neurocognitive disease. RECENT FINDINGS: The virus enters the brain during acute infection, with evidence for abnormal functioning that may occur early and often persists...
October 27, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27798497/recent-advances-in-the-diagnosis-and-management-of-tuberculous-meningitis
#14
Nguyen T H Mai, Guy E Thwaites
PURPOSE OF REVIEW: Tuberculous meningitis is a devastating infection that is hard to diagnose and treat. We have reviewed tuberculous meningitis original research published within the past 18 months, selecting studies which we consider have most advanced knowledge. RECENT FINDINGS: We review advances in diagnostic methods, anti-tuberculosis chemotherapy, and the common complications of tuberculous meningitis. New commercial molecular diagnostic tests, such as GeneXpert MTB/RIF, have an important role in tuberculous meningitis diagnosis, but as with all other available tests, they lack sensitivity and cannot rule out the disease...
October 27, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27798496/how-recent-findings-on-the-pharmacokinetics-and-pharmacodynamics-of-integrase-inhibitors-can-inform-clinical-use
#15
Emilie Elliot, Mimie Chirwa, Marta Boffito
PURPOSE OF REVIEW: This review of recent published literature and data presented at scientific meetings on integrase stand transfer inhibitors (InSTIs) examines how these findings may impact on their future clinical use. RECENT FINDINGS: Elvitegravir (EVG), raltegravir (RAL) and dolutegravir (DTG) are InSTIs recommended as first-line options for treatment naive patients by the European AIDS Clinical Society, British HIV Association, International AIDS Society-USA and DHHS...
October 27, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27755143/syphilis-hepatitis-c-and-hiv-in-eastern-europe
#16
Heather Bailey, Anna Turkova, Claire Thorne
PURPOSE OF REVIEW: Eastern Europe and Central Asia (EECA) has experienced large-scale epidemics of syphilis, hepatitis C virus (HCV) and HIV over the past few decades. Here, we review recent evidence on the epidemiology of and the response to these intersecting epidemics. RECENT FINDINGS: The HIV epidemic in EECA continues to expand, with new infections increasing by more than 50% between 2010 and 2015. HCV is now in the top 10 causes of death in EECA, with Russia accounting for more than half of the global burden of HCV infections, but access to direct-acting antivirals remains a major obstacle for control of the epidemic...
October 15, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27753690/bronchiectasis-and-other-chronic-lung-diseases-in-adolescents-living-with-hiv
#17
Engi F Attia, Robert F Miller, Rashida A Ferrand
PURPOSE OF REVIEW: The incidence of pulmonary infections has declined dramatically with improved access to antiretroviral therapy (ART) and cotrimoxazole prophylaxis, but chronic lung disease (CLD) is an increasingly recognized but poorly understood complication in adolescents with perinatally acquired HIV. RECENT FINDINGS: There is a high prevalence of chronic respiratory symptoms, abnormal spirometry and chest radiographic abnormalities among HIV-infected adolescents in sub-Saharan Africa, wherein 90% of the world's HIV-infected children live...
October 7, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27753688/the-hepatitis-d-satellite-virus-of-hepatitis-b-virus-half-opening-a-new-era-to-control-viral-infection
#18
Natali Abeywickrama-Samarakoon, Jean-Claude Cortay, Paul Dény
PURPOSE OF REVIEW: To highlight new concepts and therapeutic approaches concerning hepatitis D virus (HDV) infection. RECENT FINDINGS: Common receptor for hepatitis B virus (HBV) and HDV has been elucidated, deciphering of HDV replication is still in progress, preliminary results of phase II proof-of-concept clinical assays for entry inhibitors and cellular farnesyl transferase inhibitors are now available. SUMMARY: Hepatitis D infection remains a severe acute and chronic liver illness with the only currently approved therapy (Peg-αIFN) achieving disappointingly low rates of sustained viral response and clinical improvement...
October 7, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27749368/retroviral-restriction-nature-s-own-solution
#19
Christopher E Jones, Áine McKnight
PURPOSE OF REVIEW: The present review will discuss recent advances in the development of anti-HIV therapies inspired by studies of the mechanisms of host restriction factor-mediated resistance to HIV infection. RECENT FINDINGS: Manipulating the interplay between host cell restriction factors and viral accessory factors that overcome them can potentially be therapeutically useful. Preliminarily successful therapies - some of which are entering clinical trials - either inhibit the ability of virus to evade restriction factor-mediated immunity, or promote intracellular levels of restriction factors...
October 5, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27673713/new-antihepatitis-b-virus-drugs-under-development-and-evaluation
#20
Jiaqian Pan, Shuangmei Tong, Lei Kang, Jing Tang
PURPOSE OF REVIEW: Although available therapies can effectively inhibit hepatitis B virus (HBV) replication in patients with active chronic hepatitis B (CHB) infection, therapeutic efficacy is limited because of potential drug resistance, and an inability to mediate viral clearance and to rectify immune impairment in CHB patients. This review will summarize the state-of-the-art for anti-HBV drugs and focus on potential drugs and targets under development and evaluation. RECENT FINDINGS: New developing drugs are evaluated for their antiviral effects in the areas of interference with the viral replication cycle, elimination of closed circular DNA, modulation of host immunity and identification of the La protein and its regulator casein kinase as possible targets for the development of anti-HBV therapies...
September 26, 2016: Current Opinion in Infectious Diseases
journal
journal
29932
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"