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Journal of Biological Regulators and Homeostatic Agents

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https://www.readbyqxmd.com/read/29202575/biorevitalization-an-in-vitro-study-on-gingival-fibroblast
#1
A Palmieri, A Avantaggiato, F Cura, M Casale, M A Lopez, F Bressi, L Scapoli
Bio-revitalization is a therapy commonly used in aesthetic medicine to improve skin quality by di¬rectly integrating hyaluronic acid alone or added to other molecules (i.e. vitamins) through intradermal injections. These injections are not aimed to fill roughness but to achieve extracellular matrix optimi¬zation. The injective medical devices used in aesthetic medicine differ for hyaluronic acid content and for the presence of additional molecules that characterize the formulation of a particular company...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202574/effect-of-biostimulation-on-oral-fibroblast-a-pilot-study
#2
A Palmieri, A Avantaggiato, F Cura, R Papalia, M Casale, F Bressi, L Scapoli
Bio-stimulation is a technique in aesthetic medicine in which different drugs such as nucleotides, antioxidants and glucosaminoglycans precursors are injected in the dermis to improving the anabolic function of dermal fibroblasts, i.e., protein synthesis, replication and production of extracellular matrix components. It can be achieved with multiple intra-dermal injections, using two protocols: 1) Polydeoxyribonucleotide (PDRN) plus glucosamine sulphate (Gluc); 2) N-acetylcysteine (NAC) and amino acids (Aa) (named Bio- NAC procedure)...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202573/the-use-of-hyaluronic-acid-as-a-support-of-two-different-micronized-biomaterials-in-crestal-sinus-lift-procedures-a-report-on-two-case-studies-with-volume-comparison
#3
M A Lopez, M Casale, V Candotto, R Papalia, F Bressi, F Carinci
In the context of the trans crestal maxillary sinus lift, a wide variety of biomaterials have been used to fill the sub-antral space over the years. The materials that have a pasty consistency and are smooth and free from lumps are the most suitable to come into contact with the Schneiderian membrane which, if torn, cannot perform its graft containment function. In this study, a micronized heterologous bone in a collagen matrix of two different percentages was used in order to fill the maxillary sinus. Before using biomaterial as filler, a spray form of hyaluronic acid was used to disinfect the surgical site before and after the surgery, along with more consistent and pasty form of gel of hyaluronic acid being used in order to facilitate the detachment of the membrane...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202572/the-use-of-hyaluronic-acid-as-an-adjuvant-in-the-management-of-peri-implantitis
#4
M A Lopez, N Manzulli, A D'Angelo, D Lauritano, R Papalia, V Candotto
It is well known in dentistry that there are numerous chronic conditions that require ongoing and constant management over time, the most noteworthy being periodontal disease, gingivitis and periodontitis. Yet, in recent years, with the increase in the number of implants being placed, mucositis and peri-implantitis have become more and more prevalent pathologies. The results of the statistical analysis demonstrate that there was a slight difference between the pocket depth as measured in the treated sites at time 0 (pre-treatment) and time 1 (15 days post-treatment), although the difference was so small as to render it statistically irrelevant...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202571/the-use-of-hyaluronic-acid-as-an-adjuvant-in-the-management-of-periodontitis
#5
M A Lopez, N Manzulli, A D'Angelo, D Lauritano, M Casale, V Candotto
The emollient and restructuring action exerted on the mucous membranes by hyaluronic acid is of particular significance. This is thanks to its reparative (it stimulates angiogenesis) and soothing properties (hyaluronic acid is used in wound care to improve the processes of wound healing), which are effective in treating the symptoms of local inflammation and irritation. The purpose of this clinical trial is to evaluate the potential efficacy of nebulized hyaluronic acid in the management of chronic periodontitis in adults...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202570/the-use-of-hyaluronic-acid-as-an-adjuvant-in-the-management-of-mucositis
#6
M A Lopez, N Manzulli, A D'Angelo, V Candotto, M Casale, D Lauritano
In recent years, with an increase in the number of implants, there has been a related increase in cases of pathologies related to infections around the implant site and on the implant surface i.e. mucositis and peri-implantitis. The purpose of this pilot study is to evaluate the potential efficacy of nebulized hyaluronic acid in the management of mucositis. The results of the statistical analysis demonstrate that there was no difference between the pocket depth as measured in the treated sites at time 0 (pre-treatment) and time 1 (15 days weeks post-treatment)...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202569/the-use-of-hyaluronic-acid-as-an-adjuvant-in-the-management-of-gingivitis
#7
M A Lopez, N Manzulli, A D'Angelo, V Candotto, M Casale, D Lauritano
Recently, a specifically designed device was proposed that is able to nebulize particles with a diameter of approximately 16 micrometres to be used mainly in the management of diseases of the upper airway respiratory tract. The purpose of this pilot study is to evaluate the potential efficacy of nebulized hyaluronic acid in the management of gingivitis. The results of the statistical analysis demonstrate that there was no difference between the pocket depth as measured in the treated sites at time 0 (pre-treatment) and time 1 (15 days post-treatment)...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202568/hybrid-hyaluronic-acid-versus-high-molecular-weight-hyaluronic-acid-for-the-treatment-of-osteoarthritis-in-obese-patients
#8
R Papalia, F Russo, G Torre, E Albo, V Grimaldi, G Papalia, S Sterzi, G Vadalà, F Bressi, V Denaro
Osteoarthritis (OA) of the knee is one of the most relevant and debilitating health problems. Obesity represents one of the major risk factor for early development of OA. In the obese population, knee replacement should be delayed and eventually avoided and prefer conservative treatments including intrarticular hyaluronic acid (HA) viscosupplementation. In the present clinical randomized trial, we present a comparison between two groups of 24 obese patients which were randomized to be treated with two intrarticular injections of hybrid (low and high molecular weight) hyaluronic acid (Group A) or two injections of high molecular weight hyaluronic acid (Group B)...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202567/the-use-of-hyaluronic-acid-in-the-treatment-of-ankle-osteoarthritis-a-review-of-the-evidence
#9
R Papalia, E Albo, F Russo, A Tecame, G Torre, S Sterzi, F Bressi, V Denaro
Ankle osteoarthritis (OA) is a progressive degenerative joint disease that causes ankle pain and functional limitation especially during walking. It tends to involve younger people with high functional request and has often a post-traumatic origin. Symptoms control through conservative treatment is essential to procrastinate as long as possible the need for surgery. Although few data are present in literature about the use of local viscosupplementation in ankle OA, their potential use for ankle OA has been suggested...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202566/post-operative-nebulized-sodium-hyaluronate-versus-spray-after-functional-endoscopic-sinus-surgery-for-chronic-rhinosinusitis
#10
M Casale, A Pace, A Moffa, P Vella, L Sabatino, M A Lopez, F Salvinelli
We prospectively evaluated the efficacy of nebulized Hyaluronic Acid (HA) as an adjuvant treatment to hasten the improvement of nasal respiration and to minimize patients’ discomfort in the postoperative functional endoscopic sinus surgery (FESS) for chronic rhino-sinusitis (CRS). We enrolled 33 CRS adult patients who underwent endoscopic functional sinus surgery. They were randomly assigned into two groups: Spray-Sol group (18 patients) with HA nebulized with a new nasal device named Spray-Sol and Spray group (15 patients) with a HA nebulized with a common spray...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202565/the-efficacy-of-topical-hyaluronan-in-rhinosinusitis-a-systematic-review
#11
M Casale, P Vella, A Moffa, V Grimaldi, L Sabatino, V Rinaldi, M A Lopez, P Baptista, F Salvinelli
Rhinosinusitis is one of the most common inflammatory conditions of the nasal cavity and paranasal sinuses and is one of the most common causes of absence from work and for visits to the family doctor. The treatment strategy in both acute rhinosinusitis (ARS) and chronic rhinosinusitis (CRS) is to reduce the severity of the symptoms, minimize the duration of the disease and prevent complications. Topical therapy has become an important tool in otolaryngologists’ armamentarium for rhinosinusitis treatment. Recently, topical hyaluronic acid (HA), the major component of many extracellular matrices that promotes tissue healing, including activation and moderation of the inflammatory responses, cell proliferation, migration and angiogenesis, has been proposed for ARS and CRS adjuvant tool...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202564/systematic-review-the-efficacy-of-topical-hyaluronic-acid-on-oral-ulcers
#12
M Casale, A Moffa, P Vella, V Rinaldi, M A Lopez, V Grimaldi, F Salvinelli
The management of oral ulcers is a challenge for clinicians. Whilst there is widespread use of topical corticosteroids, antibiotics and antimicrobial, there is only weak evidence for the effectiveness of any of the topical treatments. Hyaluronic Acid (HA) has been recently proposed for topical administration in the treatment of oral ulcers and other painful oral lesions. The aim of the study is to systematically review the published literature regarding all the therapeutic effects of HA on painful oral lesions such as oral ulcers and oral lichen planus...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202563/topical-hyaluronic-acid-in-rhinitis-medicamentosa-could-our-perspective-be-changed
#13
M Casale, P Vella, A Moffa, L Sabatino, V Rinaldi, V Grimaldi, F Salvinelli
This study was designed to prospectively evaluate the role of nebulized hyaluronic acid (HA) administered for 10 days as treatment for patients with rhinitis medicamentosa (RM). RM is a pathological condition of the nasal mucosa induced by prolonged, excessive or improper use of topical decongestants. It is characterized by persistent nasal congestion that can lead the patient to increase the frequency of application and the quantity of the substance being applied, resulting in dependence on topical nasal decongestants...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202562/intrarticular-injections-of-hyaluronic-acid-for-trapezio-metacarpal-osteoarthritis-a-systematic-review
#14
R Papalia, L A Diaz, G Torre, E Albo, A Tecame, S Sterzi, F Bressi, V Denaro
Osteoarthritis (OA) of the base of the thumb, also known as Trapezio-Metacarpal (TM) OA, is a disabling condition, which mainly affects women and manual workers. When TM OA is not adequately treated, patients develop deformity and loss of function of the thumb. The surgical approach is a widespread strategy to treat this condition, but there is still no consensus on the most effective procedure. Therefore, several conservative strategies are commonly used, such as nonsteroidal anti-inflammatory drugs (NSAIDs) administration, thumb strengthening exercise, splinting, steroid (CS) and hyaluronic acid (HA) intrarticular injections...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202561/meniscal-extrusion-as-booster-of-osteoarthritis
#15
R Papalia, G Papalia, F Russo, L A Diaz, F Bressi, S Sterzi, V Denaro
Meniscal extrusion (ME) has shown to play a critical but still unclear role in osteoarthritis (OA) development. ME has been described as an important risk factor in the progression of knee OA, as it is involved in the thinning of articular cartilage, joint space narrowing, spontaneous osteonecrosis of the knee and subchondral bone marrow lesions. Meniscal damage of any degree of severity could cause ME in both compartments, but it is commonly associated with severe meniscal tears or root tears mainly in the medial meniscus...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202560/the-use-of-hyaluronic-acid-in-the-treatment-of-shoulder-capsulitis-a-systematic-review
#16
R Papalia, A Tecame, G Vadalà, F Russo, M Perna, G Papalia, F Bressi, S Sterzi, V Denaro
Adhesive capsulitis (AC) is a common pathological condition of the shoulder characterized by painful restriction of range of motion (ROM) of the glenohumeral joint. Currently, no consensus has been reached regarding the best treatment. Hyaluronic acid (HA) injection is a safe procedure that can result in significant improvement in active and passive ROM, alleviating pain and improving shoulder function. We systematically reviewed current literature in order to evaluate the best evidence about the effectiveness of intra-articular HA injection for the treatment of primary AC...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202559/hyaluronan-an-overview
#17
F Abbruzzese, F Basoli, M Costantini, S M Giannitelli, M Gori, P Mozetic, A Rainer, M Trombetta
Hyaluronic acid (HA) is a polyanionic natural polymer occurring as a linear polysaccharide composed of glucuronic acid and N-acetylglucosamine repeats. Hyaluronic acid has a wide range of applications with its excellent physicochemical properties such as biodegradability, biocompatibility, non-toxicity, non-immunogenicity and serves as an excellent tool in biomedical applications such as osteoarthritis surgery, ocular surgery, plastic surgery, tissue engineering and drug delivery. This work provides an overview on hyaluronic acid, its chemistry and biochemistry and its medical applications...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202558/malar-region-rejuvenation-through-non-invasive-techniques-hyaluronic-acid-fillers-and-lipofilling
#18
M Pascali, D Quarato, T Marianetti, F Carinci
Contour enhancements of the midface make up a dominant aspect of aesthetic surgery. The goal of midface rejuvenation is to decrease the prominence of grooves and creases as well as to provide volume to atrophied tissue. There are various options, including autologous tissue grafts, allogenic tissue grafts and alloplastic materials. In turn, patients’ needs have led to an increasing trend of less invasive treatments. In the present study, 82 implants were used for midface augmentation in 41 patients (38 women, 3 men) between January 2014 and January 2016...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29254328/role-of-biomarkers-in-adult-sepsis-and-their-application-for-a-good-laboratory-practice-a-pilot-study
#19
V Sargentini, D Collepardo, M D Alessandro, G Petralito, G Ceccarelli, F Alessandri, A Piciocchi, A Angeloni, M Venditti, A Bachetoni
This study measured Procalcitonin (PCT), Presepsin (PRE-S) and pro-Adrenomedullin (pro-ADM) in intensive care unit (ICU) patient’s blood to assess their contribution to accurate diagnosis of sepsis and potential predictive impact on prognosis. The final aim was to improve the use of infection biomarkers for optimizing the impact of laboratory medicine on clinical outcomes, focusing on the good management of resources designed to produce maximum effectiveness and efficiency. Sixty-four adult patients were studied during their hospitalization in ICU; blood samples were collected and categorized according to their clinical diagnosis and illness severity, and sepsis marker levels were measured on automated immunoassay platforms...
October 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29254327/safety-and-tolerability-of-intra-articular-hyaluronic-acid-sinovial%C3%A2-gelsyn-3tm-injections-in-the-treatment-of-knee-osteoarthritis
#20
M Abate, V Salini
Osteoarthritis (OA) is a progressively degenerative joint disease, with a very high prevalence rate that is expected to increase worldwide with the ageing of the population. Considering that OA requires long-term treatment, therapies with minimal side effects and which can be repeated as needed are warranted. Hyaluronic acid (HA), a natural glycosaminoglycan with viscoelastic properties, is a major component of synovial fluid and the extracellular matrix of the joint cartilage, and plays key roles in maintaining synovial fluid viscosity and the bio-mechanical integrity of healthy cartilage...
October 2017: Journal of Biological Regulators and Homeostatic Agents
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