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Journal of Biological Regulators and Homeostatic Agents

F Diomede, I Merciaro, S Martinotti, M Cavalcanti, S Caputi, E Mazzon, O Trubiani
miR-2861 endorsing osteoblast differentiation through the overexpression of Runt-related transcription factor 2 (RUNX2) protein has been recently described. In this study we evaluated: the performance of living construct, composed by human Periodontal Ligament Stem Cells (hPDLSCs) and 3D scaffold (EXg), and the behaviour of miR-2861/RUNX2 expression pathway on the osteogenic commitment. Human PDLSCs were seeded with and without EXg scaffold and cultured under basal and osteogenic conditions. Morphological features, adhesiveness and differentiation abilities were analysed using scanning electron and confocal laser scanning microscopy...
November 16, 2016: Journal of Biological Regulators and Homeostatic Agents
F Proietti, G De Bernardo, M Longini, D Sordino, G Scaramuzzini, M L Tataranno, E Belvisi, F Bazzini, S Perrone, G Buonocore
With advancing gestation, partial pressure of oxygen (pO2) and pH fall significantly. Hypoxia is a main factor inducing free radical generation and thereby oxidative stress (OS). Placental and fetal tissue response when oxygen becomes restricted is complex and partially known. We tested the hypothesis that changes in umbilical artery and vein blood gas concentrations modulate OS occurrence in the newborn. Seventy umbilical artery and vein plasma samples were collected from healthy term newborns immediately after delivery...
July 2016: Journal of Biological Regulators and Homeostatic Agents
A Mazza, A F Cicero, E Ramazzina, S Lenti, L Schiavon, E Casiglia, G Gussoni
Although the role of homocysteine (HCys) in secondary cardiovascular prevention has been scaled down, hyper-homocysteinemia remains a risk factor for cerebrovascular events. The aim of this study was to investigate the efficacy of nutraceuticals in lowering HCys serum levels versus a conventional vitamin supplementation in hypertensive subjects at low cardiovascular risk. One-hundred and four patients (mean age 62.8±14.5 years, 63.5% males), 52 for each treatment group, were enrolled. The study recruited patients with stage 1 essential hypertension and hyper-homocysteinemia (HCys ≥15 μmol/L), without a history of cardiovascular and cerebrovascular disease...
July 2016: Journal of Biological Regulators and Homeostatic Agents
Y Yangue, G Gambaracci, P Floridi, A Fiacca, A Guerriero, M Giansanti, M Scialpi
Immunoglobulin G4 (IgG4)-related hypertrophic pachymeningitis, which is a focally or diffusely thickened dura mater and lymphoplasmacytic infiltration with increased IgG4 bearing plasma cells, is a rare disease, and cases involving the whole cervical spine are even rarer. Here, we describe a case of probable IgG4-related hypertrophic pachymeningitis involving the whole cervical spine and the auditory canals in an 18-year-old male. The patient, who had a history of paresthesia and had previously experienced weakness, presented with generalized tonic seizures...
July 2016: Journal of Biological Regulators and Homeostatic Agents
M Focardi, V Pinchi, B Defraia, B Gualco, G Varvara, G A Norelli
Starting from an international overview of the current status of screening programs, the present paper focuses on the legal situation in Italy and the great differences among Italian regions. Since the introduction of tandem mass spectrometry (MS/MS) in the ‘90s the paradigm “one spot-one disease” changed. Only recently, some regions issued legislative acts to promote expanded newborn screening with MS/MS. This approach raises medico-legal and ethical issues because a fast neonatal diagnosis of an inborn error of metabolism (IEM) could increase chances of an early treatment and reduce disabilities, therefore citizens ought to have the same access to care countrywide...
July 2016: Journal of Biological Regulators and Homeostatic Agents
S Taurone, G Ripandelli, A Minni, R Lattanzi, S Miglietta, N Pepe, L Fumagalli, A Micera, F S Pastore, M Artico
The aim of this paper is to study the morphology and the distribution of the monoamine oxidase enzymatic system in the optic nerve of 4 month-old Wistar (young) and 28 month-old Wistar (old) rats. The optic nerve was harvested from 20 young and old rats. The segment of optic nerve was divided longitudinally into two pieces, each 0.1 mm in length. The first piece was used for transmission electron microscopy. The second piece was stained with histochemical reaction for monoamine oxidase. The agerelated changes in the optic nerve of rats include micro-anatomical details, ultrastructure and monoamine oxidase histochemical staining...
July 2016: Journal of Biological Regulators and Homeostatic Agents
G Traina, L Menchetti, F Rappa, P Casagrande-Proietti, O Barbato, L Leonardi, F Carini, F Piro, G Brecchia
Inflammatory bowel diseases (IBD) are characterized by inflammatory conditions of the intestine. Probiotic bacteria (PB) can have beneficial effects in several gastrointestinal disorders. The objectives of this study were: (i) to provide an acute experimental IBD model induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) in CD-1 mice, and (ii) to assess the preventive effects of Citogenex (Lactobacillus casei and Bifidobacterum lactis) supplementation on intestinal tissues and microbiota. Mice were inoculated intrarectally with saline, ethanol or different TNBS solutions...
July 2016: Journal of Biological Regulators and Homeostatic Agents
T Ruggiero, R Pol, D Camisassa, V Arata, I Martino, L Giaccone, S Carossa
Oral mucositis (OM) may occur in up to 100% of patients undergoing condition regimen to hematopoietic stem cell transplant (HSCT). From the patient’s perspective, OM is one of the most debilitating side effects of transplantation. It is commonly thought that oral hygiene can modify the incidence and severity of oral mucositis, therefore professional oral health care (POHC) is recommended prior to conditioning regimen for HSCT. A new strategy for the treatment of OM is sodium hyaluronate (SH) combined with amino acid precursors of collagen (Aas) (Mucosamin®)...
July 2016: Journal of Biological Regulators and Homeostatic Agents
C Ferrante, G Orlando, L Recinella, S Leone, A Chiavaroli, C Di Nisio, R Shohreh, F Manippa, A Ricciuti, M Vacca, L Brunetti
The 77 amino prepropeptide apelin has been isolated from bovine stomach tissue and several smaller fragments, including apelin-13, showed high affinity for the orphan APJ receptor. The distribution of apelinergic fibers and receptors in the hypothalamus may suggest a role of apelin-13 on energy balance regulation, albeit the studies reporting the acute effects of apelin on feeding control are inconsistent. Considering the possible involvement of apelinergic system on hypothalamic appetite controlling network, in the present study we evaluated in the rat the effects of intrahypothalamic apelin-13 injection on food intake and the involvement of orexigenic and anorexigenic hypothalamic peptides and neurotransmitters...
July 2016: Journal of Biological Regulators and Homeostatic Agents
L Imperiale, L Manganaro, A Ticino, I Piacenti, E Anastasi, S Resta, P Benedetti Panici, M G Porpora
Glanzmann’s thrombasthenia (GT) is a rare bleeding syndrome characterized by deficiency or defect of platelet aggregation complex. The pathogenesis of endometriosis is controversial but the strongest evidence leans towards retrograde menstruation. GT probably predisposes to endometriosis. The management of women affected by this disease can be difficult due to the risk of bleeding complications, especially during surgical treatment. We describe the cases of three sisters affected by endometriosis and GT, referred to our Department, who received different therapeutic management...
July 2016: Journal of Biological Regulators and Homeostatic Agents
M A Mazzei, G Bettini, C Pozzessere, S Guerrini, M Defina, M R Ambrosio, L Aprile, M Bocchia, L Volterrani
T-cell Acute Lymphoblastic Leukemia (T-cell ALL) is a rare haematological neoplasia, that affects children and less commonly adults. Female genital tract and particularly uterus involvement in acute ALL is rare. This report presents the CT features of a 64-year-old woman with uterine relapse of T-cell ALL, occurring 11 months after the diagnosis, as a second, unique relapse of disease. The patient was asymptomatic when a CT examination showed a homogenous thickness of the uterine wall in comparison with the previous CT examination...
July 2016: Journal of Biological Regulators and Homeostatic Agents
G Vicenti, L Moretti, S De Giorgi, I Caruso, M La Malfa, M Carrozzo, G Solarino, B Moretti
The association between thyroid disorders and musculoskeletal diseases has long been suspected, but it is still debated whether they have a role in the pathogenesis of shoulder diseases. In vivo and in vitro studies describe the role of thyroid hormones in bone, cartilage and tendon biology. Retrospective studies and case reports suggest that thyroid diseases should be considered as risk factors and hold prognostic value in some of the most common causes of shoulder pain. Thus, it is advisable to search for underlying thyroid disorders in these patients...
July 2016: Journal of Biological Regulators and Homeostatic Agents
V Crincoli, A Ballini, L Fatone, M B Di Bisceglie, G M Nardi, F R Grassi
The association between oral and systemic health has highlighted the importance of periodontal health and treatment, with the consequence that dental assessment and attention to oral hygiene have assumed an increasingly important part in the clinical management of patients with diabetes mellitus and rheumatoid arthritis. The aim of this work was to assess genotype frequencies in polymorphisms of genes of IL-1α-889 and IL-1β-511 in a case-controlled study population of patients affected by periodontal disease and rheumatoid arthritis or diabetes mellitus...
July 2016: Journal of Biological Regulators and Homeostatic Agents
L Bottalico, M Tatullo, M Marrelli, L Santacroce
The increase in oral rehabilitation by means of dental implants has required an evolution of the related managing protocols and correct updating of the skills of dental professionals. Postsurgical management of the clinical case is aimed to stabilize the obtained results and preserve them from adverse conditions: a healthy implant prosthesis is maintained thanks to the huge number of consolidated protocols of oral hygiene. This practice plays a decisive role in the prevention of perimplant pathologies, forming a strong basis to ensure long implant life and avoid unnecessary and painful new surgical procedures...
July 2016: Journal of Biological Regulators and Homeostatic Agents
M Gelardi, G Abbattista, V N Quaranta, N Quaranta, V Seccia, S Buttafava, F Frati, G Ciprandi
Nitric oxide (NO) is a molecule that performs many functions in the human body. The entire respiratory tract can produce NO, but the highest production occurs in the upper respiratory tract, in the paranasal sinuses in particular. The aim of the present study was to assess a new nasal NO (nNO) measurement method using the Niox MINO Nasal® device (Aerocrine AB, Solna, Sweden) and a special procedure, in order to compare the nNO values obtained in 32 healthy subjects with the values found in the international literature...
July 2016: Journal of Biological Regulators and Homeostatic Agents
A Laforgia, M Corsalini, G Stefanachi, S Tafuri, A Ballini, F Pettini, D Di Venere
The aim of the present study is to investigate the periodontal status of people with scleroderma and their response to non-surgical treatment protocol aimed at controlling the evolution of the disease. The response to non-surgical periodontal treatment was tested on patients belonging to a scleroderma group and a control group: the data show an improvement of the periodontal conditions of all these patients in response to treatment. When compared on the same diagram, a slight remission of the periodontal disease was obtained in both scleroderma and healthy patients...
July 2016: Journal of Biological Regulators and Homeostatic Agents
B H Liu, M X Sun, N Zhou, Y P Li, M Z Wang, J Yu, H S Zhou
The purpose of this study was to observe the change in plasma D-dimer of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The patients were divided into three groups, i.e., AECOPD group, stable COPD group (COPD kept stable after treatment) and a healthy control group. The content of plasma fibrinogen (FIB) and D-dimer of all research subjects was detected and the difference between groups was analyzed. Moreover, pulmonary functions of patients in the AECOPD group and the stable COPD group, including forced expiratory volume in 1 second (FEV1%) and forced vital capacity rate of 1 second (FEV1/FVC), and blood gas (oxygen partial pressure (PO2) and partial pressure of carbon dioxide (PaCO2), were detected; and the differences between the two groups and the possible correlation were analyzed...
July 2016: Journal of Biological Regulators and Homeostatic Agents
P J Song, Q Y Lu, M Y Li, X Li, F Shen
Glioma is the most common type of brain tumor. Malignant gliomas tend to have an increasingly higher incidence and are difficult to treat. Therefore, an accurate diagnosis of the grade of glioma before surgery is very important for planning surgery and determining prognosis. To compare the values of (18)F-deoxyglucose positron emission tomography/computer tomography ((18)F-FDG PET-CT) and magnetic resonance imaging (MRI) for identifying and grading gliomas, we selected 70 patients who were diagnosed as having a primary glioma or suspected glioma at the People’s Hospital of Liaocheng in Shandong, China, and divided them into an observation group, which was examined by (18)F-FDG PET-CT and a control group, which was examined by MRI...
July 2016: Journal of Biological Regulators and Homeostatic Agents
L Huang, J Zhou, Y J Zhao, G C Hu
There is growing evidence that vitamin D (VitD) plays a role in the pathophysiological mechanism of every patient undergoing hemodialysis, and this role is significantly altered in a microinflammatory state. However, it is unclear whether supplementation dosage or route of administration should be altered due to this state. Thus, the objective of our mini review and meta-analysis was to re-consider supplementation of VitD in HD patients exhibiting micro-inflammatory state. Pubmed, Web of Science and Google Scholar were searched up to January 19, 2016...
July 2016: Journal of Biological Regulators and Homeostatic Agents
X F Jia, Z Hong, J H Fan, Y M Zhang
This study aims to explore the clinical effect of mechanical fragmentation combined with recombinant tissue plasminogen activator (rt-PA) artery thrombolysis on acute cerebral infarction (ACI). One hundred and thirty-two cases of ACI patients were randomly divided into an experimental group (66 patients) and a control group (66 patients). The experimental group was treated with mechanical fragmentation combined with rt-PA artery thrombolysis method, while the control group was treated with only the rt- PA artery thrombolysis method...
July 2016: Journal of Biological Regulators and Homeostatic Agents
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