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Journal of Biological Regulators and Homeostatic Agents

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https://www.readbyqxmd.com/read/28685524/colorectal-cancer-an-update-on-the-effects-of-lycopene-on-tumor-progression-and-cell-proliferation
#1
F Carini, S David, G Tomasello, M Mazzola, P Damiani, F Rappa, L Battaglia, A Gerges Geagea, R Jurjus, A Leone
Colorectal cancer (CRC) is one of the most common cancers worldwide. Various factors, including oxidative stress, where excessive productions of reactive oxygen species (ROS) and reactive nitrogen species (RNS) occur, contribute to its pathogenesis. Numerous studies have investigated the effect of antioxidant substances derived from food such as fruits and vegetables; however, data on Lycopene are still rare. Studies on HT-29 colorectal cancer cells and on animal models have shown that lycopene has effects on cell proliferation and on the progression of the CRC by interacting with various cellular signaling pathways...
September 30, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28890831/effects-of-central-fibroblast-growth-factor-21-and-irisin-in-anxiety-like-behavior
#2
LETTER
A Chiavaroli, L Recinella, C Ferrante, S Martinotti, M Vacca, L Brunetti, G Orlando, S Leone
Adipose tissue and skeletal muscle are organs capable of secreting many bioactive molecules, such as adipomiokines that could be possibly involved in mood disorders. In the present work, we investigated the possible behavioral effects of a single intracerebroventricular (i.c.v.) injection of two adipomiokines, fibrobroblast growth factor (FGF)-21 (0.5-5.0 µg) and irisin (0.4-0.6 µg), in male rats tested in the open field and elevated plus maze tests. Prefrontal cortex levels of norepinephrine (NE), dopamine (DA) and serotonin (5-hydroxytryptamine, 5-HT) and the gene expression of catechol-O-methyltransferase (COMT), dopamine transport (DAT) and tyrosine hydroxylase (TH), were measured by high performance liquid chromatography (HPLC) analysis and real-time reverse transcription polymerase chain reaction (RT-PCR)...
September 11, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28889799/in-vitro-protective-effects-of-resveratrol-and-stilbene-alkanoic-derivatives-on-induced-oxidative-stress-on-c2c12-and-mcf7-cells
#3
L Leporini, L Giampietro, R Amororso, A Ammazzalorso, M Fantacuzzi, L Menghini, C Maccallini, C Ferrante, G Orlando, B De Filippis
Resveratrol (3,4’,5-trihydroxy-trans-stilbene) is a natural phytoalexin found in grapes and wine, which has been extensively studied for a wide range of biological effects. A large number of stilbene-containing derivatives have displayed antioxidant and antiproliferative activities on various cancer cell lines. In this study, a series of stilbene hybrids 1-9, previously reported as peroxisome proliferator-activated receptor (PPAR) agonists, were assessed at micromolar concentrations using MTT cell viability assay in C2C12 and MCF7 cell lines...
September 11, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28889734/crocus-sativus-serenoa-repens-and-pinus-massoniana-extracts-modulate-inflammatory-response-in-isolated-rat-prostate-challenged-with-lps
#4
EDITORIAL
A Chiavaroli, L Recinella, C Ferrante, M Locatelli, N Macchione, G Zengin, L Leporini, S Leone, S Martinotti, L Brunetti, M Vacca, L Menghini, G Orlando
Prostatitis is a common prostate disease that could be promoted by bacterial or non-bacterial infectious agents. In addition, inflammatory pathways involved in prostatitis have been increasingly studied, and herbal extracts endowed with anti-inflammatory effects are under investigation, individually or in combination, for their efficacy in alleviating the burden of inflammation, with possible improvements in symptoms. Serenoa repens (Serenoa), in combination with Crocus sativus (Crocus) and Pinus massoniana (Pinus), has previously shown to improve sexual function and limit urinary symptoms in patients suffering from concomitant erectile dysfunction and lower urinary tract symptoms...
September 11, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28889722/effects-of-central-fibroblast-growth-factor-21-fgf21-in-energy-balance
#5
L Recinella, S Leone, C Ferrante, A Chiavaroli, C Di Nisio, S Martinotti, M Vacca, L Brunetti, G Orlando
Fibroblast growth factor 21 (FGF21) is known as a major metabolic regulator of glucose and lipid homeostasis. Continuous intracerebroventricular (i.c.v.) administration of FGF21 was found to modulate feeding and energy expenditure in rats with diet-induced obesity, suggesting a central effect by the peptide. In this context, in the present work, we studied the effects of a single central FGF21 administration (0.5-5 µg) on feeding and energy expenditure by evaluating locomotor activity, interscapular brown adipose tissue (BAT) weight, gene expression of uncoupling protein-1 (UCP-1) in BAT and plasma norepinephrine (NE) levels in Sprague-Dawley fed rats...
September 11, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28758382/colorectal-cancer-an-update-on-the-effects-of-lycopene-on-tumor-progression-and-cell-proliferation
#6
LETTER
F Carini, S David, G Tomasello, M Mazzola, P Damiani, F Rappa, L Battaglia, F Cappello, A Jurjus, A Gerges Geagea, R Jurjus, A Leone
Colorectal cancer (CRC) is one of the most common cancers worldwide. Various factors, including oxidative stress, where excessive productions of reactive oxygen species (ROS) and reactive nitrogen species (RNS) occur, contribute to its pathogenesis. Numerous studies have investigated the effect of antioxidant substances derived from food such as fruits and vegetables; however, data on Lycopene are still rare. Studies on HT-29 colorectal cancer cells and on animal models have shown that lycopene has effects on cell proliferation and on the progression of the CRC by interacting with various cellular signaling pathways...
July 31, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28726358/colorectal-cancer-and-inflammatory-bowel-diseases-effects-of-diet-and-antioxidants
#7
LETTER
F Carini, G Tomasello, A Jurjus, A Geagea, S Al Kattar, P Damiani, E Sinagra, F Rappa, S David, F Cappello, M Mazzola, A Leone
It is well established that oxidative stress is common in inflammatory bowel diseases (IBDs). Accordingly, antioxidants are recommended for treatment. The aim of this study is to compare the effects of antioxidants contained in the various types of tea on symptoms and evolution of IBD and colorectal cancer (CRC). Analysis of the literature revealed that the theaflavin-3, 30-digallate (TFDG) contained in black tea, and epigallocatechin-3-O-gallate (EGCG) contained in green tea have protective effects against oxidative stress...
July 20, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702987/quality-of-life-and-psychological-disturbances-in-adults-with-atopic-dermatitis-in-the-czech-republic
#8
E Březinová, M Nečas, V Vašků
Atopic dermatitis (AD) leads to severe psychosocial disturbances that are quite frequently underestimated. We evaluate the quality of life (QoL) of adult patients with AD and their family members using DLQI, B-IPQ, FDLQI questionnaires, observe psychopathological features with CAQ II questionnaire and evaluate correlations between QoL, psychological disturbances and objective/subjective parameters of disease severity. A reduction in QoL has been proven by all questionnaires with statistically significant relationships between all of them...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702982/chronic-inflammation-therapy-combined-with-low-dose-cytokines-in-the-treatment-of-chronic-ulcers-of-lower-limbs
#9
S E Aragona, P Amori, G Mereghetti, J Lotti, T Lotti, G V L Colombo
Prevalence of chronic venous leg ulcers has increased from 55% to 75% in 10 years. We treat chronic vascular lesions according to a cyclic multiphase method that follows the instrumental and differential etiologic diagnosis of ulcers of the lower limbs. The AIMED (Anti Inflammatory Regenerative Medicine) operating model follows the diagnostic phase and is structured in 5 interconnected phases. Mare evaluation, pH control, biofilm removal and prevention and infections are approached according to the International Guidelines...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702981/between-history-and-gossip-the-state-of-women-relative-to-syphilis-a-traditionally-male-disease
#10
M Rovesti, F Satolli, A Zucchi, M Gandolfi, M Fioranelli, M G Roccia, M Boccalari, K França, J Lotti, N Zerbinati, T Lotti, C Feliciani
Despite the new World Health Organization data remind us how syphilis is a disease which affects both sexes equally, this pathology has always been mainly considered a male disease. While several famous men are known to be affected by syphilis, there are very few women affected by this pathology of which we have historical records. Through the lives of Mary Todd Lincoln, Catherine of Aragon, Karen Blixen and Florence Foster Jenkins, this article would like to grant dignity to all the women who contracted syphilis in the wrong historical era where, for a woman, admitting to contracting it was shameful...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702980/a-short-novel-about-the-spread-of-two-important-diseases-in-history-syphilis-and-sars
#11
M Rovesti, F Satolli, A Zucchi, M Gandolfi, M Fioranelli, M G Roccia, M Boccalari, K França, J Lotti, N Zerbinati, T Lotti, C Feliciani
Throughout the centuries, the undefended nature of man has very often manifested in cases of epidemics, which have determined scenarios of suffering and death. Through “historical” observation lens, it is possible to understand the relationship between the spread of viruses, bacteria and parasites responsible for these epidemics and the displacement of ancient or contemporary travellers. We have analysed two infective diseases, syphilis and SARS, and their role in history and in medicine.
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702977/laser-treatment-of-leg-ulcers-selected-concepts
#12
N Zerbinati, G Tchernev, U Wollina, J Lotti, K França, T Lotti, S Gianfaldoni
An overview on different laser devices, available for the treatment of the different phases of wound healing: debridement, wound repair and scars correction.
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702976/a-new-hyaluronic-acid-polymer-in-the-augmentation-and-restoration-of-labia-majora
#13
N Zerbinati, R G Haddad, A Bader, R Rauso, E D'Este, G Cipolla, A Calligaro, P Gonzalez, S Salvatore, D Serafin
Aesthetic surgery of female external genitalia has gained increasing popularity over the past decade, with reduction of the labia minora (labiaplasty) being the procedure most commonly requested and performed. Female external genitalia lose elasticity and volume with age, but few studies describe the techniques for labia majora augmentation. Currently, very few studies have investigated the effectiveness and safety of labia majora augmentation with hyaluronic acid (HA) injection. This study aims to evaluate the effectiveness and safety of labia majora augmentation with hyaluronic acid filler injection...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702975/spontaneous-retrospective-clinical-evaluation-of-a-new-phytoestrogen-based-cosmetic-gel-cream-on-postmenopausal-women%C3%A2-s-skin
#14
P Amori, J Lotti, T Lotti, G Vitiello
The purpose of this study is to evaluate the efficacy of daily application of a new phytoestrogen-based cosmetic gel cream on postmenopausal women’s skin. Sixty postmenopausal women were evaluated. Each subject was initially (T0) submitted to a hydration and sebometry test. A quantity of 50 ml of phytoestrogen-containing gel cream was given for one month to each patient. At the end of the month (T1), the tests were repeated. At the end of the study, 85% of the women showed an improvement of facial skin hydration...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702974/clinical-evaluation-of-a-new-cosmetic-cream-containing-pepha%C3%A2-tight-on-the-skin-of-childbearing-women
#15
P Amori, J Lotti, T Lotti, G Vitiello
The purpose of this study is to evaluate the efficacy of daily application of a new cosmetic cream on the skin of childbearing women. Fifty-two childbearing women were evaluated and each subject was initially (T0) prepared using an hydration and sebometry test. A quantity of 50 ml of cosmetic cream was applied for 1 month on each patient. At the end of the month (T1), the tests were repeated. At the end of the study, all enrolled women showed an improvement of facial skin hydration and sebum normalization and reduction of skin aging...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702972/laser-treatment-of-post-thyroidectomy-scar
#16
F Borgia, M Vaccaro, L Gasco, J Lotti, T Lotti, C Guarneri
A good aesthetic result in thyroid surgery is one of the main goals, as this procedure usually involves young women affected in clearly visible anatomical areas. To minimize the detrimental effects of scarring outcome, several therapeutic options have been employed. Lasers may be an alternative choice for prevention and treatment of post-surgical thyroidectomy scar. This paper reviews literature and the current knowledge on this topic. A comprehensive search in the Cochrane Library, MEDLINE and PUBMED databases was performed to identify relevant literature investigating the role of laser therapy in both prevention and treatment of unappealing scarring after thyroid surgery...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702970/a-novel-cad-cam-based-surgical-template-for-mandibular-osteoplasty-and-guided-implant-insertion
#17
G B Menchini Fabris, F Gelpi, E Giammarinaro, E Velasco Ortega, S Marconcini, U Covani
Bone shaping is often a necessary procedure prior to implant insertion in mandibular full-arch rehabilitations. Adopting guided surgery procedures is necessary to use two distinct templates: one for bone shaping, a second for guided implant insertion. The present report describes the case of a 60-year-old patient requiring a full-arch, immediately loaded implant-supported mandibular rehabilitation. A CAD/CAM-bone supported surgical template for osteoplasty was used to develop a template for guided implant during an all-on-six immediate-loaded computer-aided implant surgery...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702969/bi-layered-collagen-nano-structured-membrane-prototype-collagen-matrix-10826%C3%A2-for-soft-tissue-regeneration-in-rabbits-an-in-vivo-ultra-structural-study-of-the-early-healing-phase
#18
D De Santis, G B Menchini Fabris, J Lotti, C Palumbo, M Ferretti, R Castellani, T Lotti, G Zanotti, F Gelpi, C Covani, P F Nocini
Collagen Matrix (CM) 10826 is a nanostructured bi-layered collagen membrane obtained from type I and III porcine collagen, which in vitro has shown to have the potential to be a substitute and/or stimulant for soft oral tissue regeneration. The objective of this study was to evaluate the in vivo potential and safety of this membrane for soft tissue regeneration in the early stage of wound healing. Two soft tissue wounds (test and control) were created on the back skin of 5 rabbits (female New Zealand White Rabbits specific pathogen free)...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702968/in-vitro-evaluation-of-collagen-production-on-human-fibroblasts-treated-with-hyaluronic-acid-peg-cross-linked-with-micromolecules-of-calcium-hydroxyapatite-in-low-concentration
#19
N Zerbinati, R Rauso, P Gonzalez, M Cherubino, E D'Este, A Calligaro, S Sommatis, C Maccario, R Mocchi
Neauvia Stimulate® is a biocompatible, injectable hyaluronic acid (HA) filler (26 mg/ml) PEG cross-linked with 1% of calcium hydroxyapatite (CaHA) for facial soft-tissue augmentation that provides volume to tissues, followed by a process of neocollagenesis for improving skin quality. The aim of the present study is to evaluate the possible modulation of collagen synthesis after treating human fibroblasts cultured in vitro with the product (Lot. 160517-26-1/2 PEG). The experimental model proposed, despite being an in vitro system, allows the derivation of useful information to predict the possible activity of the product in further in vivo application...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702967/morphological-evidences-following-pegylated-filler-treatment-in-human-skin
#20
N Zerbinati, E D'Este, A Farina, R Rauso, M Cherubino, A Calligaro
In this study, microscopic, histochemical and ultrastructural observations in human skin are presented, 8 months after an injection of a novel PEGylated filler. Morphological features demonstrated an excellent integration of the filler with the connective tissue components and an effective interpenetration with the ground substance. The filler appears uniformly distributed inside the hypodermis. No segregation or encapsulation of cells and other structures was observed nor evidence of immunological adverse reaction...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
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