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International Journal of Radiation Biology

Siyuan Tang, Bailong Liu, Jiaqi Liu, Jian Wang, Ya Wang
PURPOSE: To study whether miR-21, an oncogene associated with lung tumorigenesis, affects immune response. MATERIAL AND METHODS: The cancer immune-related 786 mRNA expression was compared in lung tissue from wild type and miR-21 knock-in mice using NanoString technology. The significantly changed genes were verified using real-time PCR. E-Selectin (Sele) was subsequently identified for further examination using immunohistochemistry (IHC) and Western blot in the same lung tissue...
January 11, 2019: International Journal of Radiation Biology
C C Guerrero, I Romero, C Arceo, J E Gonzalez, G E Cortina-Ramírez, O Garcia
PURPOSE: This paper presents a calibration curve for Prematurely Condensed Chromosome Rings (PCC-ring) which are scarce in cytogenetic dosimetry; here we analyzed the behavior of the PCC-ring frequency and PCC index after gamma irradiation in the dose interval from 0 to 20 Gy. MATERIALS AND METHODS: PCC-rings were induced in lymphocytes with Calyculin A. A total of 5788 PCC cells in G1, G2/M and M/A stages were analyzed. RESULTS: The best fitting curve between the frequency of PCC ring (Y) and the Dose (D) was obtained with the equation Y = (0...
January 7, 2019: International Journal of Radiation Biology
John D Boice, Elizabeth D Ellis, Ashley P Golden, Lydia B Zablotska, Michael T Mumma, Sarah S Cohen
BACKGROUND: The study of Japanese atomic bomb survivors, exposed briefly to radiation, finds the risk of radiation-induced lung cancer to be nearly three times greater for women than for men. Because protection standards for astronauts are based on individual lifetime risk projections, this sex-specific difference limits the time women can spend in space. Populations exposed to chronic or fractionated radiation were evaluated to learn whether similar differences exist when exposures occur gradually over years...
January 7, 2019: International Journal of Radiation Biology
Ruwaidah A Mussttaf, David F L Jenkins, Awadhesh N Jha
PURPOSE: Low level laser therapy (LLLT) in the visible to near infrared spectral band (390-1100 nm) is absorption of laser light at the electronic level, without generation of heat. It may be applied in a wide range of treatments including wound healing, inflammation and pain reduction. Despite its potential beneficial impacts, the use of lasers for therapeutic purposes still remains controversial in mainstream medicine. Whilst taking into account the physical characteristics of different qualities of lasers, this review aims to provide a comprehensive account of the current literature available in the field pertaining to their potential impact at cellular and molecular levels elucidating mechanistic interactions in different mammalian models...
January 7, 2019: International Journal of Radiation Biology
Atsushi Shibata, Penny Jeggo
PURPOSE: The International Journal of Radiation Biology (IJRB) is celebrating 60 years of publishing in 2019. IJRB has made an enormous contribution to publishing papers that have enhanced our understanding of the DNA damage response (DDR) activated following exposure to ionising radiation (IR). The IR-induced DDR field has a rich history but many outstanding papers pass unread by young scientists overwhelmed by the current literature. We provide a historical reflection on key advances in the DDR field and interface them with current knowledge...
January 4, 2019: International Journal of Radiation Biology
Robert P Balog, Rowena Bacher, Polly Chang, Michael Greenstein, Songeeta Jammalamadaka, Harold Javitz, Susan J Knox, Shirley Lee, Hua Lin, Thomas Shaler, Lei Shura, Paul Stein, Kathryn Todd, David E Cooper
PURPOSE: In a significant nuclear event, hundreds of thousands of individuals will require rapid triage for absorbed radiation to ensure effective medical treatment and efficient use of medical resources. We are developing a rapid screening method to assess whether an individual received an absorbed dose of ≥2 Gy based on the analysis of a specific panel of blood proteins in a fingerstick blood sample. MATERIALS AND METHODS: We studied a data set of 1051 human blood samples obtained from radiotherapy patients, normal healthy individuals, and several special population groups...
January 3, 2019: International Journal of Radiation Biology
V A Trivillin, A Serrano, M A Garabalino, L L Colombo, E C C Pozzi, A Monti Hughes, P Curotto, S Thorp, R O Farías, S J González, S Bortolussi, S Altieri, M E Itoiz, R F Aromando, D W Nigg, A E Schwint
PURPOSE: Boron neutron capture therapy (BNCT) combines selective accumulation of 10 B carriers in tumor tissue with subsequent neutron irradiation. BNCT has been proposed for the treatment of multiple, non resectable, diffuse tumors in lung. The aim of the present study was to evaluate the therapeutic efficacy and toxicity of BNCT in an experimental model of lung metastases of colon carcinoma in BDIX rats and perform complementary survival studies. MATERIALS AND METHODS: We evaluated tumor control and toxicity in lung 2 weeks post-BNCT at 2 dose levels, including 5 experimental groups per dose level: T0 (euthanized pre-treatment), Boronophenylalanine-BNCT (BPA-BNCT), BPA + Sodium Decahydrodecaborate-BNCT ((BPA + GB-10)-BNCT), Beam only (BO) and Sham (no treatment, same manipulation)...
January 2, 2019: International Journal of Radiation Biology
Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara
PURPOSE: Ionizing irradiation has several long-term effects including progressive cognitive impairment. Cognitive deterioration generally appears to be caused by abnormalities in the hippocampal dentate gyrus, with abnormal function of parvalbumin-expressing interneurons (PV neurons) in the cerebral cortex. PV neurons are vulnerable to oxidative stress, which can be caused by ionizing irradiation. We speculated that selective impairment of specific brain regions due to ionizing irradiation may alter the degree of cognitive impairment...
January 2, 2019: International Journal of Radiation Biology
Kunwoo Cho, Tatsuhiko Imaoka, Dmitry Klokov, Tatjana Paunesku, Sisko Salomaa, Mandy Birschwilks, Simon Bouffler, Antone L Brooks, Tom K Hei, Toshiyasu Iwasaki, Tetsuya Ono, Kazuo Sakai, Andrzej Wojcik, Gayle E Woloschak, Yutaka Yamada, Nobuyuki Hamada
PURPOSE: For more than a century, ionizing radiation has been indispensable mainly in medicine and industry. Radiation research is a multidisciplinary field that investigates radiation effects. Radiation research was very active in the mid- to late 20th century, but has then faced challenges, during which time funding has fluctuated widely. Here we review historical changes in funding situations in the field of radiation research, particularly in Canada, European Union countries, Japan, South Korea, and the US...
January 2, 2019: International Journal of Radiation Biology
Yi Wang, Laura A Bannister, Soji Sebastian, Yevgeniya Le, Youssef Ismail, Candice Didychuk, Richard B Richardson, Farrah Flegal, Laura Paterson, Patrick Causey, Ali Fawaz, Heather Wyatt, Nicholas Priest, Dmitry Klokov
PURPOSE: Health risks associated with the exposure of humans to low-dose ionizing radiation are currently estimated using the Linear-No-Threshold model. Over the last few decades, however, this model has been widely criticized for inconsistency with a large body of experimental evidence. Substantial efforts have been made to delineate biological mechanisms and health related outcomes of low-dose radiation. These include a large DOE funded Low Dose program operated in the 2000s, as well as the EU funded programs, previously NOTE and DOREMI and currently MELODI...
December 24, 2018: International Journal of Radiation Biology
Brian L Fish, Thomas J MacVittie, Aniko Szabo, John E Moulder, Meetha Medhora
PURPOSE: Defined animal models are needed to pursue the FDA Animal Rule for approval of medical countermeasure for radiation injuries. This study compares WAG/RijCmcr rat and non-human primate (NHP) models for acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE). MATERIALS AND METHODS: Irradiation models include total body irradiation, partial body irradiation with bone marrow sparing and whole thorax lung irradiations. Organ specific sequelae of radiation injuries were compared using dose-response relationships...
December 21, 2018: International Journal of Radiation Biology
José L Soriano, Ana C Calpena, Eliana B Souto, Beatriz Clares
PURPOSE: Radiologic accidents or terrorist acts involving radioactive material, as well as radiation exposure in medical or industrial procedures are potential sources of risk for human health. All these risks share a common element, exposure to ionizing radiation. The extent of ionizing radiation injury will depend on a number of independent variables such as dose, type of radiation and tissue, etc. As a result of ionizing radiation exposure, biological effects can take place in acute or long term manner...
December 20, 2018: International Journal of Radiation Biology
S Anand Narayanan, John Ford, David C Zawieja
PURPOSE: Although the microvascular system is a significant target for radiation-induced effects, the lymphatic response to radiation has not been extensively investigated. This is one of the first investigations characterizing the lymphatic endothelial response to ionizing radiation. MATERIALS AND METHODS: Rat mesenteric lymphatic endothelial cells (RMLECs) were exposed to X-ray doses of 0, 0.5, 1, 1.5, and 2 Gy. RMLEC cellular response was assessed 24 and 72-h post-irradiation via measures of cellular morphometry and junctional adhesion markers...
December 20, 2018: International Journal of Radiation Biology
Maryna V Kryvokhyzha, Konstantin V Krutovsky, Namik M Rashydov
PURPOSE: Chronic and acute irradiations have drastic effects on flowering stage that plays an important role in the further seed development and can determine seed yield. The expression of the key flowering genes, AP1, CO, GI, FT, FLC, and LFY, sensitive to irradiation repair gene RAD51 and the proliferation gene PCNA2 were studied in the wild type Arabidopsis thaliana (Columbia ecotype) under chronic and acute irradiations. MATERIALS AND METHODS: Chronic irradiation was performed using the radioactive isotope 137 СsCl in two total doses of 3 cGy and 17 cGy, with the dose rate of 10-7 cGy/sec and 6...
December 20, 2018: International Journal of Radiation Biology
Richard W Leggett, Keith F Eckerman, Michael Bellamy
BACKGROUND: As part of the Million Person Study (MPS), dose reconstructions for internal emitters have been performed for several U.S. facilities where large quantities of radionuclides were handled. The main challenges and dominant sources of potential error in retrospective dose estimates for internally exposed workers have been found to vary from site to site. This paper discusses some important issues encountered in dose reconstructions performed for selected MPS sites and the approaches used to address those issues...
December 18, 2018: International Journal of Radiation Biology
Laura E Ewing, Isabelle R Miousse, Rupak Pathak, Charles M Skinner, Stanley Kosanke, Marjan Boerma, Martin Hauer-Jensen, Igor Koturbash
PURPOSE: Growing rates of metabolic syndrome and associated obesity warrant the development of appropriate animal models for better understanding of how those conditions may affect sensitivity to IR exposure. MATERIALS AND METHODS: We subjected male NZO/HlLtJ mice, a strain prone to spontaneous obesity and diabetes, to 0, 5.5, 6.37, 7.4 or 8.5 Gy (137 Cs) of total body irradiation (TBI). Mice were monitored for 30 days, after which proximal jejunum and colon tissues were collected for further histological and molecular analysis...
December 18, 2018: International Journal of Radiation Biology
Shin-Ichiro Masunaga, Yoshinori Sakurai, Hiroki Tanaka, Takushi Takata, Minoru Suzuki, Yu Sanada, Keizo Tano, Akira Maruhashi, Koji Ono
PURPOSE: To examine the effect of a change in reactor power on the response of solid tumors, referring to impact on quiescent (Q) tumor cell population. MATERIALS AND METHODS: Tumor-bearing mice received 5-bromo-2-deoxyuridine (BrdU) to label all proliferating (P) tumor cells, and were treated with boronophenylalanine-10 B (BPA) or sodium mercaptododecaborate-10 B (BSH). After reactor neutron beam irradiation at a power of 1 or 5 MW with an identical beam spectrum, cells from tumors were isolated and incubated with a cytokinesis blocker...
December 17, 2018: International Journal of Radiation Biology
Gunnar Boysen, Azemat Jamshidi-Parsian, Mary A Davis, Eric R Siegel, Rajshekhar A Kore, Ruud P M Dings, Robert J Griffin
PURPOSE: The purpose of this study was to translate our in vitro therapy approach to an in vivo model. Increased glutamine uptake is known to drive cancer cell proliferation, making tumor cells glutamine-dependent. Studying lymph-node aspirates containing malignant lung tumor cells showed a strong correlation between glutamine consumption and glutathione (GSH) excretion. Subsequent experiments with A549 and H460 lung tumor cell lines provided additional evidence for glutamine's role in driving synthesis and excretion of GSH...
December 17, 2018: International Journal of Radiation Biology
Haruo Fujinaga, Yoshio Sakai, Tatsuya Yamashita, Kuniaki Arai, Takeshi Terashima, Takuya Komura, Akihiro Seki, Kazunori Kawaguchi, Alessandro Nasti, Keiko Yoshida, Takashi Wada, Kazutaka Yamamoto, Kyo Kume, Takashi Hasegawa, Takushi Takata, Masao Honda, Shuichi Kaneko
BACKGROUND: Radiation therapy is an important alternative treatment for advanced cancer. The aim of the current study was to disclose distinct alterations of the biological characteristics of gene expression features in pancreatic cancer cells, MIAPaCa-2, following proton and X-ray irradiation. MATERIALS AND METHODS: Using cDNA microarray, we examined the gene expression alterations of MIAPaCa-2 cells following proton or X-ray irradiation. We also isolated the surviving MIAPaCa-2 cells after irradiation and analyzed their gene expression profiles...
December 17, 2018: International Journal of Radiation Biology
Mohammed Javed, Anshika Sinha, Lata Israni Shukla
BACKGROUND: The miRNA398 (microRNA398) post transcriptionally regulates the superoxide dismutase (Cu/Zn-SOD). MATERIALS AND METHODS: The miRNA398 level were quantitated in gamma irradiated 20Gy and 200Gy and nitrogen stressed seedlings by stem-loop RT-PCR (Real Time- Polymerase chain reaction). The positional preference of nucleotide for miR398 families and new targets was done. The superoxide dismutase enzyme was assayed in native PAGE (Polyacrylamide gel electrophoresis)...
December 17, 2018: International Journal of Radiation Biology
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