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International Journal of Radiation Biology

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https://www.readbyqxmd.com/read/28421857/risk-of-solid-cancer-in-low-dose-rate-radiation-epidemiological-studies-and-the-dose-rate-effectiveness-factor
#1
Roy Shore, Linda Walsh, Tamara Azizova, Werner Rühm
PURPOSE: Estimated radiation risks used for radiation protection purposes have been based primarily on the Life Span Study (LSS) of atomic bomb survivors who received brief exposures at high dose rates, many with high doses. Information is needed regarding radiation risks from low dose-rate (LDR) exposures to low linear-energy-transfer (low-LET) radiation. We conducted a meta-analysis of LDR epidemiologic studies that provide dose-response estimates of total solid cancer risk in adulthood in comparison to corresponding LSS risks, in order to estimate a dose rate effectiveness factor (DREF)...
April 19, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28409667/radiobiology-self-assessment-guide
#2
Elaine M Zeman
No abstract text is available yet for this article.
April 14, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28397587/photon-induced-auger-effect-in-biological-systems-a-review
#3
Akinari Yokoya, Takashi Ito
PURPOSE: We review interesting findings reported in the studies of the biological effects induced by inner-shell ionization with the aim of interpreting them from a mechanistic viewpoint of Auger effect of in particular atoms on to the different biological systems. MATERIALS AND METHODS: Cited more than 70 published papers on the Auger effects ranging from DNA related elements (carbon, nitrogen, oxygen and phosphorus) to mammalian cells. Externally administrated bromine, iodine, and platinum have also been cited for the present endeavor...
April 11, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28376642/cardiovascular-sequel-of-neck-irradiation-in-head-and-neck-cancer-patients
#4
Manish Goyal, Pragya Shukla, Deepak Gupta, Shyam Bisht, Nar Singh Verma, Sunita Tiwari, Madan Lal Bhatt
PURPOSE: Introduction: The baroreflex is an important afferent mechanism controlling autonomic functions. As afferent nerves course through the neck, they are susceptible to damage by neck irradiation in the head and neck cancer patients. With increased survival of head and neck cancer patients because of improved therapy, the cardiovascular morbidity and mortality in them have become apparent and is of clinical concern. There are few case reports of baroreflex failure as a chronic sequel to neck irradiation...
April 5, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28346025/guidance-on-radiation-dose-limits-for-the-lens-of-the-eye-overview-of-the-recommendations-in-ncrp-commentary-no-26
#5
Lawrence T Dauer, Elizabeth A Ainsbury, Joseph Dynlacht, David Hoel, Barbara E K Klein, Donald Mayer, Christina R Prescott, Raymond H Thornton, Eliseo Vano, Gayle E Woloschak, Cynthia M Flannery, Lee E Goldstein, Nobuyuki Hamada, Phung K Tran, Michael P Grissom, Eleanor A Blakely
PURPOSE: This review summarizes the conclusions and recommendations of the new National Council on Radiation Protection and Measurements (NCRP) Commentary No. 26 guidance on radiation dose limits for the lens of the eye. The NCRP addressed radiation protection principles in respect to the lens of the eye, discussed the current understanding of eye biology and lens effects, reviewed and evaluated epidemiology, and assessed exposed populations with the potential for significant radiation exposures to the lens while suggesting monitoring and protection practices...
April 3, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28281400/evaluation-of-thiol-disulphide-homeostasis-in-radiation-workers
#6
Ural Koc, Sinan Tan, Ahmet Goktug Ertem, Mehmet Gumus, Betul Ozbek, Ozcan Erel
PURPOSE: To evaluate thiol-disulphide homeostasis - a novel, easily calculated, readily available, and relatively cheap oxidative stress marker - in radiation workers and compare the results with healthy controls. MATERIALS AND METHODS: A total of 108 participants were enrolled in the study including 63 hospital workers occupationally exposed to ionizing radiation in the units of interventional radiology, interventional cardiology and nuclear medicine. A control group consisted of 45 individuals staff in the same hospital...
April 3, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28281393/altered-expression-of-a-metformin-mediated-radiation-response-in-sa-nh-and-fsa-tumor-cells-treated-under-in-vitro-and-in-vivo-growth-conditions
#7
Jeffrey S Murley, Richard C Miller, Raziye Rana Senlik, Alfred W Rademaker, David J Grdina
PURPOSE: To assess the radiosensitizing effect of the biguanide drug metformin used alone or in combination with reactive oxygen species (ROS) modifying agents N-acetyl-L-cysteine (NAC) or emodin, and contrasted to the mitochondrial complex 1 inhibitor rotenone in altering the radiation responses of the p53 wild-type SA-NH and p53 mutant FSa mouse tumor lines grown either in vitro or in vivo. MATERIALS AND METHODS: Tumor cells were grown to confluence in vitro and exposed to a single 4 Gy dose in the presence or absence of metformin (5 mM) and ROS modifiers or to 10 Gy with or without metformin as tumors in the flanks of C3H mice using a tumor growth delay assay...
March 28, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28346027/biologically-based-mechanistic-models-of-radiation-related-carcinogenesis-applied-to-epidemiological-data
#8
W Rühm, M Eidemüller, J C Kaiser
PURPOSE: Biologically-based mechanistic models that are used in combining current understanding of human carcinogenesis with epidemiological studies were reviewed. Assessment was made of how well they fit the data, whether they account for non-linear radiobiological low-dose effects, and whether they suggest any implications for the dose response at low doses and dose rates. However, the present paper does not make an attempt to provide a complete review of the existing literature on biologically-based models and their application to epidemiological data...
March 27, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28332427/response-to-letter-by-s-m-j-mortazavi-s-a-r-mortazavi-and-m-paknahad
#9
Süleyman Kaplan
No abstract text is available yet for this article.
March 23, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28332426/comments-on-neuroprotective-effects-of-melatonin-and-omega-3-on-hippocampal-cells-prenatally-exposed-to-900%C3%A2-mhz-electromagnetic-fields
#10
Sar Mortazavi, Smj Mortazavi, Maryam Paknahad
No abstract text is available yet for this article.
March 23, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28306402/the-effect-of-radiation-dose-on-the-onset-and-progression-of-radiation-induced-brain-necrosis-in-the-rat-model
#11
Brad A Hartl, Htet S W Ma, Katherine S Hansen, Julian Perks, Michael S Kent, Ruben C Fragoso, Laura Marcu
PURPOSE: To provide a comprehensive understanding of how the selection of radiation dose affects the temporal and spatial progression of radiation-induced necrosis in the rat model. MATERIALS AND METHODS: Necrosis was induced with a single fraction of radiation exposure, at doses ranging between 20 and 60 Gy, to the right hemisphere of 8-week-old Fischer rats from a linear accelerator. The development and progression of necrosis in the rats was monitored and quantified every other week with T1- and T2-weighted gadolinium contrast-enhanced MRI studies...
March 17, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28299960/molecular-dissection-of-the-response-of-the-rice-systemic-acquired-resistance-deficient-1-sard1-gene-to-different-types-of-ionizing-radiation
#12
In Jung Jung, Jung Eun Hwang, Sung Min Han, Dong Sub Kim, Joon-Woo Ahn, Hong-Il Choi, Soon-Jae Kwon, Si-Yong Kang, Jin-Baek Kim
PURPOSE: Exposure to ionizing radiation induces plant defenses by regulating the expression of response genes. The systemic acquired resistance deficient 1 (SARD1) is a key gene in plant defense response. In this study, the function of Oryza sativa SARD1 (OsSARD1) was investigated after exposure of seeds/plants to ionizing radiation, jasmonic acid (JA) or salicylic acid (SA). MATERIALS AND METHODS: Rice seeds exposed to two types of ionizing radiations (gamma ray [GR] and ion beam [IB]) were analyzed by quantitative reverse transcription PCR (qRT-PCR) to identify the genes that are altered in response to ionizing radiation...
March 16, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28291374/mln4924-and-2dg-combined-treatment-enhances-the-efficiency-of-radiotherapy-in-breast-cancer-cells
#13
Maryam Oladghaffari, Ali Shabestani Monfared, Alireza Farajollahi, Behzad Baradaran, Mohsen Mohammadi, Dariush Shanehbandi, Mohammad Asghari Jafar Abadi, Jalil Pirayesh Islamian
PURPOSE: Two-deoxy-D-glucose (2DG) causes cytotoxicity in the cancer cells by disrupting the thiol metabolism, and MLN4924 inactivates the SCF E3 ligase and so causes the accumulation of its substrates which trigger apoptosis and hence might enhance the efficiency of radiotherapy and overcame on the radioresistance of the cancer cells. MATERIALS AND METHODS: SKBR3 and MCF-7 breast cancer cells were treated with 500 μM 2DG and/or MLN4924 (30, 100, 200 and 300 nM), and in combination in the presence and absence of 1, 1...
March 14, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28290238/ra-226-bioaccumulation-and-growth-indices-in-fish
#14
Xiaopei Shi, Richard Smith, Colin Seymour, Carmel Mothersill
PURPOSE: To determine the accumulated activity of Ra-226 in fathead minnows fed with environmentally relevant levels of Ra-226 for 5 months in water at 20 °C, and to evaluate the influence of this level of Ra-226 on the growth of fathead minnows. METHODS: Fathead minnows were fed with fish food containing 10-10,000 mBq/g Ra-226 for 5 months. At the end of the experiment, the fish were sacrificed, flash frozen in liquid nitrogen and kept at -20 °C. Longitudinal sections of 40 μm thickness were cut at the middle of the fish body using a cryostat...
March 14, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28287037/uva-radiation-augments-cytotoxic-activity-of-psoralens-in-melanoma-cells
#15
Dorota Wrześniok, Artur Beberok, Jakub Rok, Marcin Delijewski, Anna Hechmann, Martyna Oprzondek, Zuzanna Rzepka, Barbara Bacler-Żbikowska, Ewa Buszman
PURPOSE: Melanoma is an aggressive form of skin cancer. The aim of the study was to evaluate the influence of UVA radiation and psoralens: 5-methoxypsoralen (5-MOP) or 8-methoxypsoralen (8-MOP) on melanoma cells viability. MATERIALS AND METHODS: The amelanotic C32 and melanotic COLO829 human melanoma cell lines were exposed to increasing concentrations of psoralens (0.1-100 μM) in the presence or absence of UVA radiation. Cell viability was evaluated by the WST-1 assay...
March 13, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28287035/biological-basis-of-radiation-protection-needs-rejuvenation
#16
Tatjana Paunesku, Benjamin Haley, Antone Brooks, Gayle E Woloschak
PURPOSE: Human beings encounter radiation in many different situations - from proximity to radioactive waste sites to participation in medical procedures using X-rays etc. Limits for radiation exposures are legally regulated; however, current radiation protection policy does not explicitly acknowledge that biological, cellular and molecular effects of low doses and low dose rates of radiation differ from effects induced by medium and high dose radiation exposures. Recent technical developments in biology and medicine, from single cell techniques to big data computational research, have enabled new approaches for study of biology of low doses of radiation...
March 13, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28287017/oxidative-stress-and-gsts-genetic-polymorphisms-in-medical-staff-professionally-exposed-to-ionizing-radiation
#17
Hajer Doukali, Ghada Ben Salah, Latifa Hamdaoui, Mounira Hajjaji, Mouna Tabebi, Leila Ammar-Keskes, Mohamed-Elarbi Masmoudi, Hassen Kamoun
PURPOSE: Ionizing radiation (IR) is considered as a diagnostic and therapeutic tool in medicine. However, chronic occupational exposure of medical staff to IR may affect the antioxidant status and, as result, DNA damage and cancers as well. The objective of our study was to evaluate the oxidative stress profile caused by IR in 29 Tunisian medical staff from radiology and radiotherapy departments, and to find an association between the GSTM1null, GSTT1null, and GSTP1 Ile105Val polymorphisms and oxidative stress biomarkers...
March 13, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28281358/synchrotron-microtomography-to-evaluate-effects-of-different-polychemotherapy-drugs-to-cortical-bone-structure
#18
L P Nogueira, R Alessio, A Mantuano, G Sena, C E de Almeida, G Tromba, A P Almeida, C Salata, M V G Colaço, D Braz, R C Barroso
PURPOSE: In the present work, femur diaphysis of rats, treated with two different chemotherapy drugs, AC (doxorubicin + cyclophosphamide) and TC (docetaxel + cyclophosphamide) were evaluated by 3D morphological analysis using synchrotron radiation microtomography. MATERIALS AND METHODS: Wistar rats were classified into three groups. One group received doses of docetaxel and cyclophosphamide (G1) - TC regimen; another group received doses of doxorubicin and cyclophosphamide (G2) - AC regimen; while control group (G0) received no further treatment...
March 10, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28281355/systemic-effects-of-ionizing-radiation-at-the-proteome-and-metabolome-levels-in-the-blood-of-cancer-patients-treated-with-radiotherapy-the-influence-of-inflammation-and-radiation-toxicity
#19
Karol Jelonek, Monika Pietrowska, Piotr Widlak
Purpose Blood is the most common replacement tissue used to study systemic responses of organisms to different types of pathological conditions and environmental insults. Local irradiation during cancer radiotherapy induces whole body responses that can be observed at the blood proteome and metabolome levels. Hence, comparative blood proteomics and metabolomics are emerging approaches used in the discovery of radiation biomarkers. These techniques enable the simultaneous measurement of hundreds of molecules and the identification of sets of components that can discriminate different physiological states of the human body...
March 10, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28264626/quantitative-changes-in-the-protein-and-mirna-cargo-of-plasma-exosome-like-vesicles-after-exposure-to-ionizing-radiation
#20
Ramesh Yentrapalli, Juliane Merl-Pham, Omid Azimzadeh, Lisa Mutschelknaus, Carsten Peters, Stefanie M Hauck, Michael J Atkinson, Soile Tapio, Simone Moertl
PURPOSE: Multiple cell types secrete exosome-like extracellular vesicles (ELVs) to the extracellular environment. Pathological conditions can produce characteristic changes to the vesicle cargo. We investigated if ionizing radiation is capable of inducing changes in the protein and microRNA (miRNA) cargo of ELVs. MATERIALS AND METHODS: Whole blood samples from healthy donors were irradiated with 2 Gy gamma rays and then peripheral blood mononuclear cells and plasma were separated from residual blood and co-cultivated for 24 h...
March 7, 2017: International Journal of Radiation Biology
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