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International Journal of Radiation Biology

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https://www.readbyqxmd.com/read/28067111/extremely-low-level-microwaves-attenuate-immune-imbalance-induced-by-inhalation-exposure-to-low-level-toluene-in-mice
#1
Elena G Novoselova, Olga V Glushkova, Maxim O Khrenov, Tatyana V Novoselova, Sergey M Lunin, Eugeny E Fesenko
PURPOSE: To clarify whether extremely low-level microwaves (MW) alone or in combination with p38 inhibitor affect immune cell responses to inhalation exposure of mice to low-level toluene. MATERIALS AND METHODS: The cytokine profile, heat shock proteins expression, and the activity of several signal cascades, namely, NF-κB, SAPK/JNK, IRF-3, p38 MAPK, and TLR4 were measured in spleen lymphocytes of mice treated to air-delivered toluene (0.6 mg/m(3)) or extremely low-level microwaves (8...
January 9, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28067097/evidences-for-amelioration-of-reserpine-induced-fibromyalgia-in-rat-by-low-dose-of-gamma-irradiation-and-duloxetine
#2
Eman E Shibrya, Rasha R Radwan, Mai A Abd El Fattah, Esmat A Shabaan, Sanaa A Kenawy
OBJECTIVE: Fibromyalgia is a prevalent disorder characterized by chronic widespread pain and complex symptoms. This study was conducted to investigate the potential therapeutic effect of low-dose irradiation (LDI) alone or in combination with duloxetine on the reserpine-induced fibromyalgia in rats. METHODS: Fibromyalgia was induced by administration of reserpine (1 mg/kg/s.c) for 3 consecutive days. Duloxetine (30 mg/kg, p.o) was administered 60 min before a forced swimming test (FST), and rats were exposed to a single dose of γ-radiation (0...
January 9, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28067096/differential-response-of-normal-and-transformed-mammary-epithelial-cells-to-combined-treatment-of-anti-mir-21-and-radiation
#3
Vanja Radulovic, Theresa Heider, Sabine Richter, Simone Moertl, Michael J Atkinson, Nataša Anastasov
PURPOSE: MicroRNA miR-21 has emerged as a therapeutic target in the treatment of breast cancer. This study was designed to compare the responses of breast cancer cells and non-transformed breast epithelial cells to a combined regimen of miR-21 inhibition and radiation. MATERIALS AND METHODS: The MDA-MB-361 (breast cancer) and MCF-10A (non-transformed mammary epithelial) cell lines were used for the comparison in this in vitro study. The stable knockdown of miR-21 was performed by using lentiviral approach...
January 9, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28067089/metabolomic-applications-in-radiation-biodosimetry-exploring-radiation-effects-through-small-molecules
#4
Evan L Pannkuk, Albert J Fornace, Evagelia C Laiakis
PURPOSE: Exposure of the general population to ionizing radiation has increased in the past decades, primarily due to long distance travel and medical procedures. On the other hand, accidental exposures, nuclear accidents, and elevated threats of terrorism with the potential detonation of a radiological dispersal device or improvised nuclear device in a major city, all have led to increased needs for rapid biodosimetry and assessment of exposure to different radiation qualities and scenarios...
January 9, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28054831/lessons-learned-from-an-unstable-genomic-landscape
#5
Charles L Limoli
PURPOSE: This brief historical perspective will highlight the many accomplishments of the late William "Bill" Morgan, and how his laboratory during the mid-1990s shaped the field of genomic instability. Bill focused on the processes responsible for radiation-induced genomic instability, and while ionizing radiation was known to induce this phenomenon, the precise causes were poorly understood. Here we revisit Bill's unique approach to these problems, as he advocated the use of novel mammalian cell lines to tease apart the mechanisms responsible for destabilizing an otherwise stable nuclear genome...
January 5, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28051886/static-magnetic-field-reduces-blood-pressure-short-term-variability-and-enhances-baro-receptor-reflex-sensitivity-in-spontaneously-hypertensive-rats
#6
Tatjana Tasić, Drago M Djordjević, Silvio R De Luka, Alexander M Trbovich, Nina Japundžić-Žigon
Purpose It has been shown that chronic exposure of young spontaneously hypertensive rats to static magnetic field (SMF) delays the development of overt hypertension. Therefore the aim of the present work was to investigate the effects of SMF on autonomic cardiovascular control in adult spontaneously hypertensive rats. Materials and methods Experiments were performed in freely moving spontaneously hypertensive rats equipped with femoral arterial catheter for blood pressure recording. Spontaneously hypertensive rats were exposed for 30 days to upward oriented SMF (n = 17) or downward oriented SMF (n = 17) of 16 mT intensity...
January 4, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28045339/imaging-biodistribution-and-efficacy-evaluation-of-188-re-human-serum-albumin-microspheres-via-intraarterial-route-in-an-orthotopic-hepatoma-model
#7
Liang-Cheng Chen, Ya-Jen Chang, Su-Jung Chen, Wan-Chi Lee, Chih-Hsien Chang, Te-Wei Lee, Jui-Hung Shien
Purpose Liver cancer is the second most common cause of death worldwide. This study was to investigate the SPECT/CT, ultrasound, biodistribution and therapeutic evaluation of (188)Re-human serum albumin microspheres ((188)Re-HSAM) in the GP7TB orthotopic hepatoma rat model. Materials and methods HSAM was labeled with (188)Re by using home-made kit and microwave system. The (188)Re-HSAM was administered via intraarterial route. The in vivo distribution of (188)Re-HSAM was determined by biodistribution analysis and nanoSPECT/CT system...
January 3, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28044470/gold-nanoparticles-as-dose-enhancement-agent-for-kilovoltage-x-ray-therapy-of-melanoma
#8
So-Ra Kim, Eun-Hee Kim
PURPOSE: Melanoma is mainly treated by surgery and rarely with radiation because of the high radio-resistance of this tumor. Nevertheless, radiotherapy is the preferred treatment modality for unresectable lesions and avoiding cosmetic disfigurement caused by surgical excision. This study investigated the therapeutic advantage of gold nanoparticles (AuNPs) for kilovoltage X-ray treatment of melanoma. MATERIALS AND METHODS: Commercial AuNPs were evaluated for cytotoxicity and cellular internalization...
January 3, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28044469/epigenetic-silencing-and-activation-of-transcription-influence-on-the-radiation-sensitivity-of-glioma-cell-lines
#9
A Sak, D Kübler, K Bannik, M Groneberg, S Strunz, R Kriehuber, M Stuschke
PURPOSE: To uncover the role of EZH2 and its opponent ASHL2, a polycomb and trithorax group protein, respectively on the radioresponsiveness of glioma cell lines. MATERIAL AND METHODS: Expression of EZH2 and ASHL2 was inhibited by siRNA in glioma cell lines. The effect on histone methylation, gene expression, DNA damage repair signaling, cell cycle checkpoints, apoptosis and tumor control were evaluated. RESULTS: Inhibition of EZH2 (EZH2i) led to a transcriptional dysregulation with upregulation of 544 and downregulation of 445 genes...
January 3, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27899034/ionizing-radiation-sensitivity-of-the-ocular-lens-and-its-dose-rate-dependence
#10
Nobuyuki Hamada
PURPOSE: In 2011, the International Commission on Radiological Protection reduced the threshold for the lens effects of low linear energy transfer (LET) radiation. On one hand, the revised threshold of 0.5 Gy is much lower than previously recommended thresholds, but mechanisms behind high radiosensitivity remain incompletely understood. On the other hand, such a threshold is independent of dose rate, in contrast to previously recommended separate thresholds each for single and fractionated/protracted exposures...
December 22, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28000521/proteomic-analysis-of-irradiated-lung-tissue-of-mice-using-gel-based-proteomic-approach
#11
Shabir Hussain, Ajaswrata Dutta, Ashish Sarkar, Abhinav Singh, Manju Lata Gupta, Sagarika Biswas
PURPOSE: Exposure to radiation causes severe alterations of protein expression level inside the cell, thus it may influence the biological events and stress response. In the present investigation, we have demonstrated the effect of radiation on mice lung tissues. MATERIALS AND METHODS: Two-dimensional gel electrophoresis (2-DE) coupled with MALDI-TOF/TOF was used to check the expression changes in lung proteome profile of strain 'A' female mice after exposure to lethal doses of gamma irradiation at different time periods (24 and 48 h)...
December 21, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27892758/gamma-radiation-tolerance-in-different-life-stages-of-the-fruit-fly-drosophila-melanogaster
#12
Jagdish Gopal Paithankar, K Deeksha, Rajashekhar K Patil
PURPOSE: Insects are known to have higher levels of radiation tolerance than mammals. The fruit fly Drosophila provides opportunities for genetic analysis of radiation tolerance in insects. A knowledge of stage-specific sensitivity is required to understand the mechanisms and test the existing hypothesis of insect radiation tolerance. MATERIALS AND METHODS: Drosophila melanogaster were irradiated using gamma rays at different life stages. Irradiation doses were chosen to start from 100-2200 Gy with increments of 100 Gy, with a dose rate of 12...
December 20, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27827272/the-inhibitory-effect-of-meadowsweet-filipendula-ulmaria-on-radiation-induced-carcinogenesis-in-rats
#13
Vladimir G Bespalov, Valery A Alexandrov, Alexandr L Semenov, Elena G Kovan'ko, Sergey D Ivanov, Galina I Vysochina, Vera A Kostikova, Denis A Baranenko
PURPOSE: To examine the ability of the meadowsweet preparation to inhibit carcinogenesis induced by ionizing radiation in female rats. MATERIALS AND METHODS: The chemical composition of meadowsweet (Filipendula ulmaria) raw material (ethanol and aqueous extracts of meadowsweet flowers) has been studied for the presence of flavonoids, tannins and catechins. Adult female LIO strain rats were subjected to a single whole body γ-irradiation at a dose of 4 Gy in animal experiments...
December 15, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27834112/restorative-role-of-persimmon-leaf-diospyros-kaki-to-gamma-irradiation-induced-oxidative-stress-and-tissue-injury-in-rats
#14
Omaima M Ashry, Elham M Hussein, Afrag Sh Abd El-Azime
PURPOSE: To evaluate the efficacy of persimmon leaf extract (PL (as a rich plant source) in modulation of radiation-induced liver injury and some metabolic variations in gamma-irradiated rats. MATERIALS AND METHODS: PL at a dose of 1000 mg/kg body weight (P1000) was administered to male albino rats via gastric intubation for 15 days after whole body γ-irradiation (6 Gy). RESULTS: Irradiated rats showed significant decreases in hepatic glutathione content (GSH), superoxide dismutase (SOD), catalase (CAT) and xanthine dehydrogenase (XDH) activities with significant increases in malondialdehyde (MDA) level and xanthine oxidase (XO) activity designating oxidative stress...
December 14, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27813704/temporal-variability-of-the-quality-of-taraxacum-officinale-seed-progeny-from-the-east-ural-radioactive-trace-is-there-an-interaction-between-low-level-radiation-and-weather-conditions
#15
Vera N Pozolotina, Elena V Antonova
HYPOTHESIS: The multiple stressors, in different combinations, may impact differently upon seed quality, and low-level doses of radiation may enhance synergistic or antagonistic effects. RESULTS: During 1991-2014 we investigated the quality of the dandelion (Taraxacum officinale s.l.) seed progeny growing under low-level radiation exposure at the East-Ural Radioactive Trace (EURT) area (result of the Kyshtym accident, Russia), and in plants from areas exposed to background radiation...
December 12, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27935337/induction-of-interleukin-1%C3%AE-by-mouse-mammary-tumor-irradiation-promotes-triple-negative-breast-cancer-cells-invasion-and-metastasis-development
#16
Gina Bouchard, Hélène Therriault, Rachel Bujold, Caroline Saucier, Benoit Paquette
PURPOSE: Radiotherapy increases the level of inflammatory cytokines, some of which are known to promote metastasis. In a mouse model of triple negative breast cancer (TNBC), we determined whether irradiation of the mammary tumor increases the level of key cytokines and favors the development of lung metastases. MATERIAL AND METHODS: D2A1 TNBC cells were implanted in the mammary glands of a Balb/c mouse and then 7 days old tumors were irradiated (4x6 Gy). The cytokines IL-1β, IL-4, IL-6, IL-10, IL-17 and MIP-2 were quantified in plasma before, midway and after irradiation...
December 9, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27827005/injectable-gossypol-loaded-pluronic-p85-micelles-for-cancer-chemoradiotherapy
#17
Keishiro Tomoda, Hsin C Chiang, Kevin R Kozak, Glen S Kwon
PURPOSE: The aim of tumor-specific chemoradiotherapy is to achieve synergistic anticancer effects with clinically acceptable toxicity. Our previous studies showed that Pluronic P85 augments radiation cancer cell killing of (±)-gossypol in vitro. In this study, the radiosensitizing effect of (-)-gossypol, more potent Bcl protein inhibitor, with Pluronic P85 was investigated. MATERIALS AND METHODS: The inhibitory effect of (-)-gossypol solubilized Pluronic P85 with 0-8 Gy of radiation on clonogenic survival rate of A549 human lung adenocarcinoma cells was investigated in vitro...
December 9, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27924669/effects-of-15%C3%A2-hz-square-wave-magnetic-fields-on-the-voltage-gated-sodium-and-potassium-channels-in-prefrontal-cortex-pyramidal-neurons
#18
Yu Zheng, Jun-Rong Dou, Yang Gao, Lei Dong, Gang Li
PURPOSE: Although magnetic fields have significant effects on neurons, little is known about the mechanisms behind their effects. The present study aimed to measure the effects of magnetic fields on ion channels in cortical pyramidal neurons. MATERIALS AND METHODS: Cortical pyramidal neurons of Kunming mice were isolated and then subjected to 15 Hz, 1 mT square wave (duty ratio 50%) magnetic fields stimulation. Sodium currents (INa), transient potassium currents (IA) and delayed rectifier potassium currents (IK) were recorded by whole-cell patch clamp method...
December 7, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27834104/upregulating-dab2ip-expression-via-egr-1-inhibition-a-new-approach-for-overcoming-fractionated-irradiation-induced-cross-tolerance-to-ionizing-radiation-and-mitomycin-c-in-tumor-cells
#19
Rulve Chang, Hui He, Guangmin Mao, Zhaolu Kong
PURPOSE: To evaluate the effect of fractionated irradiation (FI) on tumor cells' sensitivity to ionizing radiation (IR) and antineoplastic drugs, and examine the potential of early growth response-1 (EGR-1) inhibition to sensitize tumor cells to IR. MATERIALS AND METHODS: PC3 and HepG2 cells were subjected 10 times to γ-rays at 2 Gy. The surviving cells were named PC3/R and HepG2/R, respectively. The cells' sensitivity to irradiation and chemotherapeutic drugs, including cisplatin (PT), doxorubicin (DOX), mitomycin C (MMC) and 5-fluorouracil (5-FU), were identified by colony formation assay and MMT method, respectively...
December 7, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27921519/different-responses-of-drosophila-subobscura-isofemale-lines-to-extremely-low-frequency-magnetic-field-50%C3%A2-hz-0-5%C3%A2-mt-fitness-components-and-locomotor-activity
#20
Danica Zmejkoski, Branka Petković, Sofija Pavković-Lučić, Zlatko Prolić, Marko Anđelković, Tatjana Savić
PURPOSE: Extremely low frequency (ELF) magnetic fields as essential ecological factor may induce specific responses in genetically different lines. The subject of this study was to investigate the impact of ELF magnetic field on fitness components and locomotor activity of five Drosophila subobscura isofemale (IF) lines. MATERIALS AND METHODS: Each D. subobscura IF line, arbitrarily named: B16/1, B24/4, B39/1, B57/2 and B69/5, was maintained in five full-sib inbreeding generations...
December 6, 2016: International Journal of Radiation Biology
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