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International Journal of Radiation Biology

Sisko Salomaa, Ohtsura Niwa, Antone L Brooks
No abstract text is available yet for this article.
May 5, 2017: International Journal of Radiation Biology
Elaine M Zeman
No abstract text is available yet for this article.
May 5, 2017: International Journal of Radiation Biology
Soafara Andrianome, Laurent Hugueville, René de Seze, Brahim Selmaoui
THE PURPOSE: The objective of this study was to assess the level of various salivary and urinary markers of patients with EHS and to compare them with those of the healthy control group. MATERIALS AND METHODS: We analyzed samples from 30 EHS individuals and a matched control group of 25 individuals (non EHS) aged between 22 and 66. We quantified cortisol both in saliva and urine, alpha amylase (sAA), immunoglobulin A and C Reactive Protein levels in saliva and neopterin in urine (uNeopterin)...
May 3, 2017: International Journal of Radiation Biology
Noura M Thabet, Enas M Moustafa
PURPOSE: This study was performed to explore the synergistic effect of a seleno-organic compound Ebselen (Ebs) and/or γ-radiation to exert antitumor effects on human breast cancer (MCF-7) cell line in vitro. MATERIALS AND METHODS: Ebs cytotoxicity at various concentration (10, 25, 50 and 75 μg), cell proliferation and clonogenic assay of Ebs and/or γ-radiation (at 1, 3 and 6Gy), expression of p-IκBα and NF-κB, inflammatory cytokines levels (TNF-α, IL-2, INF-γ, IL-10 and TGF-β), apoptotic factors (Caspase-3, Granzyme-B and TRAIL) and angiogenic factor (VEGF) were investigated...
May 2, 2017: International Journal of Radiation Biology
Xiaoyan Chen, Ping Wang, Fei Guo, Xiangdong Wang, Juan Wang, Jinping Xu, Dexiao Yuan, Jianghong Zhang, Chunlin Shao
PURPOSE: Tumor resistance towards radiation has been a big obstacle to patient's poor prognosis of lung cancer. It has been reported that hypoxia and autophagy are contributing to this resistance partly. However, there is controversy over whether autophagy plays positive role in cancer therapy or not. We aim to find out the specific mechanism of radiation resistance. MATERIALS AND METHODS: A549 cells were treated with conditioned medium (CM) under 12h hypoxia or normoxia before irradiation...
May 2, 2017: International Journal of Radiation Biology
Mandar Sengupta, Sarmistha Sen Raychaudhuri
PURPOSE: Environmental changes generate free radicals and reactive oxygen species (ROS) resulting in abiotic stress in plants. This causes alterations in germination, morphology, growth and development ultimately leading to yield loss. Gamma irradiation was used to experimentally induce oxidative damage in an important pulse crop Vigna radiata (L.) Wilczek or Mung bean. Our research is aimed towards augmentation of oxidative stress tolerance through treatment with a group of aliphatic amines known as polyamines...
April 28, 2017: International Journal of Radiation Biology
Magnus Sabel, Marie Kalm, Thomas Björk-Eriksson, Birgitta Lannering, Klas Blomgren
PURPOSE: To explore if hypothermia can reduce the harmful effects of ionizing radiation on the neurogenic regions of the brain in young rats. MATERIAL AND METHODS: Postnatal day 9 rats were randomized into two treatment groups, hypo- and normothermia, or a control group. Treatment groups were placed in chambers submerged in temperature-controlled water baths (30˚C and 36˚C) for 8 h, after receiving a single fraction of 8 Gy to the left hemisphere. Seven days post-irradiation, we measured the sizes of the subventricular zone (SVZ) and the granule cell layer (GCL) of the hippocampus, and counted the number of proliferating (phospho-histone H3+) cells and microglia (Iba1+ cells)...
April 28, 2017: International Journal of Radiation Biology
Karim Khoshgard, Parvaneh Kiani, Abbas Haghparast, Leila Hosseinzadeh, Mohammad Taghi Eivazi
BACKGROUND AND PURPOSE: The aim of radiotherapy is delivering lethal damage to cancerous tissue while preserving adjacent normal tissues. Radiation absorbed dose of the tumoral cells can increase when high atomic nanoparticles are present in them during irradiation. Also the dose-rate is an important aspect in radiation effects that determines the biological results of a given dose. This in-vitro study investigates the dose-rate effect on the induced radiosensitivity by dextran coated iron oxide in cancer cells...
April 28, 2017: International Journal of Radiation Biology
Cong Liu, Jing Liu, Yuhui Hao, Ying Gu, Zhangyou Yang, Hong Li, Rong Li
PURPOSE: 6,7,3',4'-tetrahydroxyisoflavone(T3) is a novel chemically synthesized compound reported in our previous study. This study was designed to explore the radioprotective effect of T3, and if so, its potential mechanisms. MATERIALS AND METHODS: KunMing mice were exposed to various doses of γ irradiation (60 Co) after treated with DMSO or T3. Briefly, survival rate, dose reducing factor (DRF), body weight change (%), spleen index (SI) and thymus index (TI) of irradiated mice with or without different doses of T3 treatment were evaluated routinely...
April 28, 2017: International Journal of Radiation Biology
Marko Miliša, Domagoj Đikić, Tvrtko Mandić, Dino Grozić, Ivan Čolić, Ana Ostojić
PURPOSE: To test the effects of short term exposure of aquatic organisms to electric field (EF) with negligible magnetic component. MATERIALS AND METHODS: We built a plate capacitor that served as a source of EF of strengths that can be found in nature near transmission lines. We exposed two cultured protist species Euglena viridis and Paramecium caudatum to EFs for 24 hours and monitored their abundance, morphology, intracellular superoxide anion (by DHE), hydrogen peroxide by (H2DCF) and MDA contents, catalase (CAT) and superoxide dismutase (SOD) activity...
April 28, 2017: International Journal of Radiation Biology
Roy Shore, Linda Walsh, Tamara Azizova, Werner Rühm
PURPOSE: Estimated radiation risks used for radiation protection purposes have been based primarily on the Life Span Study (LSS) of atomic bomb survivors who received brief exposures at high dose rates, many with high doses. Information is needed regarding radiation risks from low dose-rate (LDR) exposures to low linear-energy-transfer (low-LET) radiation. We conducted a meta-analysis of LDR epidemiologic studies that provide dose-response estimates of total solid cancer risk in adulthood in comparison to corresponding LSS risks, in order to estimate a dose rate effectiveness factor (DREF)...
April 19, 2017: International Journal of Radiation Biology
Akinari Yokoya, Takashi Ito
PURPOSE: We review interesting findings reported in the studies of the biological effects induced by inner-shell ionization with the aim of interpreting them from a mechanistic viewpoint of Auger effect of in particular atoms on to the different biological systems. MATERIALS AND METHODS: Cited more than 70 published papers on the Auger effects ranging from DNA related elements (carbon, nitrogen, oxygen and phosphorus) to mammalian cells. Externally administrated bromine, iodine, and platinum have also been cited for the present endeavor...
April 11, 2017: International Journal of Radiation Biology
Manish Goyal, Pragya Shukla, Deepak Gupta, Shyam Bisht, Nar Singh Verma, Sunita Tiwari, Madan Lal Bhatt
PURPOSE: Introduction: The baroreflex is an important afferent mechanism controlling autonomic functions. As afferent nerves course through the neck, they are susceptible to damage by neck irradiation in the head and neck cancer patients. With increased survival of head and neck cancer patients because of improved therapy, the cardiovascular morbidity and mortality in them have become apparent and is of clinical concern. There are few case reports of baroreflex failure as a chronic sequel to neck irradiation...
April 5, 2017: International Journal of Radiation Biology
Lawrence T Dauer, Elizabeth A Ainsbury, Joseph Dynlacht, David Hoel, Barbara E K Klein, Donald Mayer, Christina R Prescott, Raymond H Thornton, Eliseo Vano, Gayle E Woloschak, Cynthia M Flannery, Lee E Goldstein, Nobuyuki Hamada, Phung K Tran, Michael P Grissom, Eleanor A Blakely
PURPOSE: This review summarizes the conclusions and recommendations of the new National Council on Radiation Protection and Measurements (NCRP) Commentary No. 26 guidance on radiation dose limits for the lens of the eye. The NCRP addressed radiation protection principles in respect to the lens of the eye, discussed the current understanding of eye biology and lens effects, reviewed and evaluated epidemiology, and assessed exposed populations with the potential for significant radiation exposures to the lens while suggesting monitoring and protection practices...
April 3, 2017: International Journal of Radiation Biology
Ural Koc, Sinan Tan, Ahmet Goktug Ertem, Mehmet Gumus, Betul Ozbek, Ozcan Erel
PURPOSE: To evaluate thiol-disulphide homeostasis - a novel, easily calculated, readily available, and relatively cheap oxidative stress marker - in radiation workers and compare the results with healthy controls. MATERIALS AND METHODS: A total of 108 participants were enrolled in the study including 63 hospital workers occupationally exposed to ionizing radiation in the units of interventional radiology, interventional cardiology and nuclear medicine. A control group consisted of 45 individuals staff in the same hospital...
April 3, 2017: International Journal of Radiation Biology
Karol Jelonek, Monika Pietrowska, Piotr Widlak
PURPOSE: Blood is the most common replacement tissue used to study systemic responses of organisms to different types of pathological conditions and environmental insults. Local irradiation during cancer radiotherapy induces whole body responses that can be observed at the blood proteome and metabolome levels. Hence, comparative blood proteomics and metabolomics are emerging approaches used in the discovery of radiation biomarkers. These techniques enable the simultaneous measurement of hundreds of molecules and the identification of sets of components that can discriminate different physiological states of the human body...
March 30, 2017: International Journal of Radiation Biology
Jeffrey S Murley, Richard C Miller, Raziye Rana Senlik, Alfred W Rademaker, David J Grdina
PURPOSE: To assess the radiosensitizing effect of the biguanide drug metformin used alone or in combination with reactive oxygen species (ROS) modifying agents N-acetyl-L-cysteine (NAC) or emodin, and contrasted to the mitochondrial complex 1 inhibitor rotenone in altering the radiation responses of the p53 wild-type SA-NH and p53 mutant FSa mouse tumor lines grown either in vitro or in vivo. MATERIALS AND METHODS: Tumor cells were grown to confluence in vitro and exposed to a single 4 Gy dose in the presence or absence of metformin (5 mM) and ROS modifiers or to 10 Gy with or without metformin as tumors in the flanks of C3H mice using a tumor growth delay assay...
March 28, 2017: International Journal of Radiation Biology
W Rühm, M Eidemüller, J C Kaiser
PURPOSE: Biologically-based mechanistic models that are used in combining current understanding of human carcinogenesis with epidemiological studies were reviewed. Assessment was made of how well they fit the data, whether they account for non-linear radiobiological low-dose effects, and whether they suggest any implications for the dose response at low doses and dose rates. However, the present paper does not make an attempt to provide a complete review of the existing literature on biologically-based models and their application to epidemiological data...
March 27, 2017: International Journal of Radiation Biology
Süleyman Kaplan
No abstract text is available yet for this article.
March 23, 2017: International Journal of Radiation Biology
Sar Mortazavi, Smj Mortazavi, Maryam Paknahad
No abstract text is available yet for this article.
March 23, 2017: International Journal of Radiation Biology
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