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International Journal of Radiation Biology

Marcos Tassano, Natalia Oddone, Marcelo Fernández, Williams Porcal, María Fernanda García, Wilner Martínez, Juan Claudio Benech, Pablo Cabral
PURPOSE: Study of rhenium-188 labeling of polyamidoamine (PAMAM) generation 4 (G4) dendrimer and its evaluation on biodistribution and chromosomal aberrations in melanoma cells induced by ionizing radiation as potential treatment agent. MATERIALS AND METHODS: Dendrimers were first conjugated with Suc-HYNIC (Succinimidyl 6-hydrazinopyridine-3-carboxylic acid hydrochloride). Dendrimer-HYNIC was then incubated with 188 ReO4 - . Biodistribution were performed administrating 188 Re-dendrimer to normal (NM) or melanoma-bearing mice (MBM)...
May 18, 2018: International Journal of Radiation Biology
Valentina Pinzi, Ilaria Bisogno, Francesco Prada, Emilio Ciusani, Laura Fariselli
PURPOSE: Meningiomas account for one third of primary intracranial tumors, nevertheless information on meningioma cell lines and in vivo models is scant. Although radiotherapy is one of the most relevant therapeutic options for the treatment patients with meningioma, radiobiological research to understand tumor responses to this treatment is far from being thoroughly understood. The aim of this report is to provide a comprehensive picture of the current literature on this field, so as to foster s research in this regard...
May 18, 2018: International Journal of Radiation Biology
Manuel Higueras, J E González, Marina Di Giorgio, J F Barquinero
PURPOSE: To present Poisson exact goodness-of-fit tests as alternatives and complements to the asymptotic u-test, which is the most widely used in cytogenetic biodosimetry, to decide whether a sample of chromosomal aberrations in blood cells comes from an homogeneous or inhomogeneous exposure. MATERIALS AND METHODS: Three Poisson exact goodness-of-fit test from the literature are introduced and implemented in the R environment. A Shiny R Studio application, named GOF Poisson, has been updated for the purpose of giving support to this work...
May 18, 2018: International Journal of Radiation Biology
Ville Jäntti, Tuomo Ylinen, Narayan Puthanmadam Subramaniyam, Kotoe Kamata, Arvi Yli-Hankala, Pasi Kauppinen, Eila Sonkajärvi
Purpose - Anesthesiologists have increasingly started to use EEG based indexes to estimate the level and type of unconsciousness. However, the physiology and biophysics are poorly understood in anesthesiological literature. Methods - EEG was recorded from electrodes on the surface of head, including scalp, as well as DBS (deep brain stimulation) electrodes implanted deep in the brain. Mathematical modeling with a realistic head model was performed to create illustrative images of the sensitivity of electrode montages...
May 18, 2018: International Journal of Radiation Biology
Poushali Bhattacharya, Neena G Shetake, Badri N Pandey, Amit Kumar
PURPOSE: One of the most important implications of 'Radiation Biology' research is to improve cancer radiotherapy with minimum side effects. In this regard, combination of chemotherapy with radiation has significantly improved tumor control as well as overall survival in a variety of cancers. However, this has been achieved at the cost of significant normal tissue toxicity, due to the lack of specificity of chemotherapy. Membrane-localized receptor tyrosine kinases (RTKs) have been found to play a driving role in various hallmarks of cancer...
May 18, 2018: International Journal of Radiation Biology
Maie Bachmann, Laura Päeske, Andreas A Ioannides, Jaanus Lass, Hiie Hinrikus
PURPOSE: This feasibility study is aimed to clarify the possibility of detection of microwave radiation (MWR) induced event related potential (ERP) in electroencephalographic (EEG) signal. METHODS: To trigger onset and offset effects in EEG, repetitive MWR stimuli were used. Four EEG recordings on a single subject were performed, each about one month apart. The subject was exposed to 450 MHz MWR modulated at 40 Hz at the 1 g peak spatial average specific absorption rate of 0...
May 18, 2018: International Journal of Radiation Biology
Ki Moon Seong, TaeWoo Kwon, Jina Park, BuHyun Youn, Hyuck-Jin Cha, Yonghwan Kim, Changjong Moon, Seung-Sook Lee, Young Woo Jin
PURPOSE: Since the 2011 Fukushima nuclear power plant accident, Korean radiation experts have agreed that reliable data on health risks of low-dose radiation (LDR) are needed to ease the anxiety of lay people. The intent of this study was to devise a sustainable biological program suited for the research environment in Korea and aimed at the health effects of radiation exposures <100 millisieverts (mSv). To address pressing public concerns over LDR risk, we investigated the current understanding of LDR effects by analyzing the previous reports of international authorities for radiation protection and research publications that appeared after the Chernobyl accident...
May 18, 2018: International Journal of Radiation Biology
Hiie Hinrikus, Maie Bachmann, Jaanus Lass
PURPOSE: This topic review aims to explain the mechanism of low-level microwave radiation effect based on published research results. The review presents the analysis of theoretical and experimental results comprising underlying physics and derived biological-physiological consequences supported by experimental data. CONCLUSIONS: The rotation of dipolar molecules causes polarization of dielectric medium and restructuring of hydrogen bonds between these molecules...
May 18, 2018: International Journal of Radiation Biology
Halina Lisowska, Lei Cheng, Alice Sollazzo, Lovisa Lundholm, Aneta Wegierek-Ciuk, Sylwester Sommer, Anna Lankoff, Andrzej Wojcik
PURPOSE: Low temperature at exposure has been shown to act in a radioprotective manner at the level of cytogenetic damage. It was suggested to be due to an effective transformation of DNA damage to chromosomal damage at low temperature. The purpose of the study was to analyze the kinetics of aberration formation during the first hours after exposing human peripheral blood lymphocytes to ionizing radiation at 0.8 °C and 37 °C. MATERIALS AND METHODS: To this end, we applied the technique of premature chromosome condensation...
May 3, 2018: International Journal of Radiation Biology
Savneet Kaur Bains, Kim Chapman, Scott Bright, Anish Senan, Munira Kadhim, Predrag Slijepcevic
PURPOSE: To investigate the effects of ionizing radiation on telomere length and telomerase activity in human lens epithelial cells. There are studies suggesting evidence of telomere length in association with opacity of the lens; however, these studies have been conducted on Canine Lens cells. Our study was designed to understand further the effects of different doses of ionizing radiation on telomere length and telomerase activity in cultured human lens epithelium cells from three Donors...
May 3, 2018: International Journal of Radiation Biology
M Dos Santos, V Paget, M Ben Kacem, F Trompier, M Benadjaoud, A François, O Guipaud, M Benderitter, F Milliat
PURPOSE: The main objective of radiobiology is to establish links between doses and radiation-induced biological effects. In this context, well-defined dosimetry protocols are crucial to the determination of experimental protocols. This work proposes a new dosimetry protocol for cell irradiation in a SARRP and shows the importance of the modification of some parameters defined in dosimetry protocol for physical dose and biological outcomes. MATERIALS AND METHODS: Once all parameters of the configuration were defined, dosimetry measurements with ionization chambers and EBT3 films were performed to evaluate the dose rate and the attenuation due to the cell culture medium...
April 27, 2018: International Journal of Radiation Biology
Dithu Thekkekkara, Duraiswamy B, Sudhir Chandna, M J Nanjan
PURPOSE: Exposure to ionizing radiation causes damage to the genomic integrity and stability of the cell. Though a large number of molecules have been studied for their radioprotective capability, no single agent is available today that meets all the requirements of a good radiprotector. In this study, we have investigated a combination of Resveratrol (RSV) and 3, 3'-Diindolyl methane (DIM) for its efficacy for radioprotection. It is our hypothesis that this combination that possesses less toxicity than synthetic compounds, free radical scavenging potential and the capacity to interfere with the several of the signalling cascades that trigger damage to cell by ionizing radiation, may possess good radioprotective capability...
April 19, 2018: International Journal of Radiation Biology
Barbara S van der Meij, Laisa Teleni, Marielle Pkj Engelen, Nicolaas Ep Deutz
PURPOSE: Amino acids are involved in many physiological processes in the body and serve as building blocks of proteins which are the main component of muscle mass. Often patients with cancer experience muscle wasting, which is associated with poor outcomes. The purpose of this paper is to discuss amino acid kinetics in cancer, review the evidence on the response to nutrition in patients with cancer, and to give recommendations on the appropriate level of amino acid or protein intake in cancer...
April 18, 2018: International Journal of Radiation Biology
Liyuan Sun, Liangjing Chen, Lina Bai, Yongpeng Xia, Xiaobo Yang, Wei Jiang, Wenjun Sun
PURPOSE: Exposure to extremely low frequency electromagnetic fields (ELF-MFs) could elicit biological effects including carcinogenesis. However, the detailed mechanisms by which these ELF-MFs interact with biological system are currently unclear. Previously, we found that a 50-Hz magnetic field (MF) exposure could induce epidermal growth factor receptor (EGFR) clustering and phosphorylation on cell membranes. In the present experiment, the possible roles of reactive oxygen species (ROS) in MF-induced EGFR clustering were investigated...
April 16, 2018: International Journal of Radiation Biology
Arif Osman Tokat, Aylin Akbulut, Deniz Billur, Gokhan Koca, Pinar Bayram, Serdar Kuru, Sezgin Karasu, Suheyla Aydogmus, Hüseyin Cakmak, Sengul Ozmert, Meliha Korkmaz
PURPOSE: Radioactive I131 (RAI) therapy is a standard method to ablate the remnant thyroidal tissue after total thyroidectomy and its metastases in differentiated thyroid carcinomas, however, I131 also accumulates in non-thyroidal tissue, which may cause adverse effects and limit the I131 dose required for treatment. We hypothesized that montelukast, a known agent with anti-inflammatory and anti-oxidant properties, would ameliorate the radiation-induced histopathological characteristics such as pneumonitis and fibrosis in rat lungs after RAI...
April 16, 2018: International Journal of Radiation Biology
Jelena Pajic, Branislav Rovcanin, Dusan Kekic, Dubravka Jovicic, Aleksandar Ps Milovanovic
PURPOSE: Ionizing radiation (IR) can act on atomic structures, producing damage to biomolecules. Earlier investigations evaluating individual radiosensitivity in vitro were focused on cytogenetic biomarkers (chromosomal aberrations - CA and micronuclei - MN). Since IR can also cause oxidative damage by producing reactive oxygen species, the main goal of this investigation was to establish the influence of redox status on CA and MN frequency in human peripheral blood lymphocytes. MATERIALS AND METHODS: Blood samples from 56 healthy donors were irradiated at doses of 0, 0...
April 16, 2018: International Journal of Radiation Biology
M A Motaleb, Adli A Selim, M El-Tawoosy, M H Sanad, M A El-Hashash
PURPOSE: dioxime derivative is reported to exhibit high affinity towards tumor cells. The objective of the present study is to synthesis a new dioxime derivative to be labeled with technetium-99m for using as solid tumor marker. MATERIALS AND METHODS: ((2E,2'E,3E,3'E)-3,3'-(cyclohexane-1,2-diylbis (azanylylidene)) bis-(butan-2-one)dioxime was synthesized by condensation of Butan-2,3-dione monooxime and diaminocyclohexane and labeled with 99m Tc, The in-vivo distribution of the agent were studied by carrying out biodistribution in tumor bearing Albino mice...
April 16, 2018: International Journal of Radiation Biology
Apurva Watve, Mamta Gupta, Subash Khushu, Poonam Rana
PURPOSE: Radiation induced white matter changes are well known and vastly studied. However, radiation induced gray matter alterations are still a research question. In the present study, these changes were assessed in a longitudinal manner using Diffusion Tensor Imaging (DTI) and further compared for cranial and whole body radiation exposure. MATERIALS AND METHODS: Male mice (C57BL/6) were irradiated with cranial or whole body radiation followed by DTI study at 7T animal MRI system during pre-dose, sub-acute and early delayed phases of radiation sickness...
April 16, 2018: International Journal of Radiation Biology
A López-Furelos, A Salas-Sanchez, F J Ares-Pena, J Leiro-Vidal, E López-Martín
PURPOSE: The aim of this study was to determine whether exposure to radiation from single or multiple radio-frequency (RF) signals at 900 and 2450 MHz would induce effects in the RAW 264.7 cell line. MATERIALS AND METHODS: Cell cultures were exposed to single or combined RF for 4, 24, 48 or 72 hours in a GTEM electromagnetic test chamber. At the end of the radiation exposure time, viability and cell growth were analyzed by flow cytometry, nitric oxide (NO) production was measured by colorimetry, the expression of HSP70 and TNF-α was ascertained by qPCR and phagocytic activity was observed by microscopy...
April 16, 2018: International Journal of Radiation Biology
Thomas E Woolley, Juan Belmonte-Beitia, Gabriel F Calvo, John W Hopewell, Eamonn A Gaffney, Bleddyn Jones
PURPOSE: To estimate, from experimental data, the retreatment radiation 'tolerances' of the spinal cord at different times after initial treatment. MATERIALS AND METHODS: A model was developed to show the relationship between the biological effective doses (BED) for two separate courses of treatment with the BED of each course being expressed as a percentage of the designated 'retreatment tolerance' BED value, denoted BED1 and BED2 . The primate data of Ang et al (2001) was used to determine the fitted parameters...
April 5, 2018: International Journal of Radiation Biology
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