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International Journal of Radiation Biology

Sachin N Hajare, Jyoti Tripathi, Satyendra Gautam
PURPOSE: Current study was aimed to enhance the confidence of consumers as well as entrepreneurs towards food irradiation program. MATERIALS AND METHODS: In this work, safety of high dose (25 kGy) irradiated meat samples (HDIMS) was ascertained by scoring mutation frequency through a long-term sub-culturing study in Escherichia coli MG1655 cells (ATCC 700926) up to 1500 generations (at 1%), 250 generations (at 5 and 10%) and human lymphoblast thymidine kinase heterozygote (TK6) cell line (ATCC CRL-8015) [at two gene loci, tk(-/+) (thymidine kinase) and hprt(+) (Hypoxanthine Phosphoribosyltransferase)] up to 156 generations using goat meat sample...
November 13, 2017: International Journal of Radiation Biology
M Büyükyıldız, M Kurudirek
PURPOSE: In this paper, the effective atomic numbers (Zeff), electron densities (Neff), exposure buildup factor (EBF) and energy absorption buildup factor (EABF) of healthy (H), carcinoma (C) and equivalent (E) breast tissues were investigated to quantify differences in radiological parameters between the tissues in the continuous energy region. For these purposes, Zeffs and Neffs, of healthy, carcinoma and equivalent (H-C-E) breast tissues were calculated for interaction of gamma rays and charged particles with selected tissues...
November 9, 2017: International Journal of Radiation Biology
Deguan Li, Renxiang Chen, Yi-Wen Wang, Albert J Fornace, Heng-Hong Li
PURPOSE: In this study we addressed the question whether radiation-induced adverse effects on T cell activation are associated with alterations of T cell checkpoint receptors. MATERIALS AND METHODS: Expression levels of checkpoint receptors on T cell subpopulations were analyzed at multiple post-radiation time points ranging from one to four weeks in mice receiving a single fraction of 1 or 4 Gy of γ-ray. T cell activation associated metabolic changes were assessed...
November 7, 2017: International Journal of Radiation Biology
Masoumeh Karami, Siamak Asri-Rezaie, Banafshe Dormanesh, Ali Nazarizadeh
PURPOSE: The current study was undertaken to evaluate radioprotective effects of selenium nanoparticles in irradiation induced nephropathy of mice model compared to sodium selenite. MATERIALS AND METHODS: Forty-five mice were divided into 3 major groups including control, selenium nanoparticle and sodium selenite. Each major group was further subdivided into 3 more groups receiving various doses of 0, 2 and 8 Gy gamma irradiation. Both of the supplements were administered intraperitoneally with the dose of 0...
November 7, 2017: International Journal of Radiation Biology
Surajit Pathak, Antara Banerjee, Wen-Jian Meng, Suman Kumar Nandy, Madhumala Gopinath, Xiao-Feng Sun
AIM: To demonstrate the radiation responses of TAZ in colon cancer. METHODS: TAZ expression was examined in colon cancer cell lines SW480, KM12C, SW620 and KM12L4a. We used KM12C and KM12L4a for the experiment by using X-rays and UV rays (mW/cm(2)). We used HCT15 cell line to test the expression of TAZ by using an anti-TAZ drug, viz., 9-fluorenone, which is a hippo-yap/taz signaling inhibitor. The experimentation also involved exposing HCT15 cell line, to radiation...
November 3, 2017: International Journal of Radiation Biology
Mitat Arıcıgil, Mehmet Akif Dündar, Abitter Yücel, Meryem Aktan, Mehmet Akif Alan, Sıdıka Fındık, İbrahim Kılınç
PURPOSE: We aimed to investigate the protective effect of melatonin in radiotherapy-induced thyroid gland injury in an experimental rat model. MATERIALS AND METHODS: Thirty-two rats were divided into 4 groups: the control group, melatonin treatment group, radiotherapy group and melatonin plus radiotherapy group. The neck region of each rat was defined by simulation and radiated with 2 Gray (Gy) per min with 6-MV photon beams, for a total dose of 18 Gy. Melatonin was administered at a dose of 50 mg/kg through intraperitoneal injection, 15 min prior to radiation exposure...
November 2, 2017: International Journal of Radiation Biology
Olga Komova, Eugene Krasavin, Elena Nasonova, Larisa Mel'nikova, Nina Shmakova, Micaela Cunha, Etienne Testa, Michaël Beuve
PURPOSE: Our study aimed at evaluating: 1) whether well established variability in radioadaptive response (AR) in various donor blood lymphocytes might be attributed to inter-individual differences in radiosensitivity to different low dose levels; 2) whether AR is reproducibly present over time in the lymphocytes of AR-positive individuals. Experimental procedure: Whole blood samples of 3 donors were exposed to low doses (2-30 cGy) of γ-radiation alone (G0 phase) or followed by a 1 Gy challenge dose (late S/early G2 phase), and chromosome aberration were scored to assess the dose-response relationship and adaptive response, correspondingly...
November 2, 2017: International Journal of Radiation Biology
Georgy Malinovsky, Ilia Yarmoshenko, Michael Zhukovsky
OBJECTIVES: Cohen's ecological analyses revealed negative correlation between the lung cancer mortality and average indoor radon concentration in the US counties, that contradicts to linear non-threshold (LNT) model and is inconsistent with results of case-control studies. The aim of the study was to analyze dependence between radon exposure and lung cancer mortality rate taking into account more complete data on smoking and new findings on association of the lung cancer with human papillomavirus (HPV) infection...
November 2, 2017: International Journal of Radiation Biology
Carmel Mothersill, Andrej Rusin, Cristian Fernandez-Palomo, Colin Seymour
PURPOSE: This review, which arose from a Radiation Research Society History symposium, traces the history of "bystander effects" or "indirect effects" (also known as "abscopal effects", "clastogenic effects" and more recently "the secretosome"). In 1905, Murphy first drew attention to effects caused by the injection of irradiated cells into animals. In the present day, bystander effects are seen as part of the secretosome, where they coordinate responses to stressors at the tissue, organism, and population level...
November 2, 2017: International Journal of Radiation Biology
T J Welsh, L D Stringer, R Caldwell, J E Carpenter, D M Suckling
PURPOSE: Brown marmorated stink bugs, Halyomorpha halys Stål (Hemiptera: Pentatomidae), are regularly intercepted, but there are few eradication tools. Currently, no sterile insect technique program exists for Hemiptera. MATERIALS AND METHODS: Adult males were irradiated at 4-60 Gy, mated and their progeny reared for two generations, with mortality assessed at F1 egg, F1 adult and F2 egg stages. RESULTS: The F1 eggs showed a dose response to irradiation between 4 and 36 Gy, with 97% sterility at 16 Gy, and higher doses producing complete egg mortality...
November 2, 2017: International Journal of Radiation Biology
Murat Kurudirek
PURPOSE: Characterization of soft tissue, water and air in terms of effective atomic number (Zeff) with respect to the interactions of hadrons, leptons and isotopes of hydrogen. METHOD: Mass collision stopping powers (MCSPs) were calculated first using Bethe formula. Then, these values were used to estimate Zeff using linear-logarithmic interpolation. A scale equation was also used to calculate MCSP. RESULTS: Variation in Zeff, over the 0...
November 2, 2017: International Journal of Radiation Biology
Steven B Zhang, Shanmin Yang, Zhenhuan Zhang, Amy Zhang, Mei Zhang, Liangjie Yin, Katherine Casey-Sawicki, Steven Swarts, Sadasivan Vidyasagar, Lurong Zhang, Paul Okunieff
PURPOSE: To investigate the late effects of thoracic region irradiation (TRI) on mouse body weight. MATERIALS AND METHODS: Female C57BL/6 mice were divided into nonirradiated, 5 Gy total body irradiation, 9 Gy sub-total body irradiation, and 12.5 Gy thoracic region irradiation (TRI) groups. Changes in mouse weight were monitored every other week at similar time points for 12 months. The anatomical characteristics of abdominal visceral fat distribution were recorded, and mitochondrial DNA copy number in the hearts and livers and lipid metabolic signaling in the liver were analyzed...
October 24, 2017: International Journal of Radiation Biology
Bruce F Kimler
This paper provides a historical perspective on the origin and development of Target Theory and how its central concepts have influenced the thought processes of radiation biologists for almost a century.
October 16, 2017: International Journal of Radiation Biology
So-Ra Kim, Eun-Hee Kim
PURPOSE: Despite the high radioresistance of melanoma, unresectable lesions can be subjected to radiation treatment with the use of gold nanoparticles (AuNPs) as a dose-enhancing agent preferentially loaded on these lesions. The modality of single high-dose treatment has been investigated to confirm its therapeutic efficiency for AuNP-treated melanoma cells. This study explores the feasibility of utilizing AuNPs in fractionated radiation therapy of melanoma for further therapeutic gain...
October 16, 2017: International Journal of Radiation Biology
M A Acosta-Elías, A J Burgara-Estrella, J A Sarabia-Sainz, E Silva-Campa, A Angulo-Molina, K J Santacruz-Gómez, B Castaneda, D Soto-Puebla, A I Ledesma-Osuna, R Melendrez-Amavizca, M Pedroza-Montero
PURPOSE: Storage and ionizing radiation of human red blood cells (RBC) produce alterations on RBC membranes and modify their normal shape and functionality. We investigated early morphological and biochemical changes in RBC due to those stressing agents at the nanoscale level and their impact on blood quality. MATERIALS AND METHODS: Whole blood samples from healthy donors were γ-irradiated with 15, 25, 35 and 50 Gy. Non-irradiated and non-stored RBC were used as control samples...
October 16, 2017: International Journal of Radiation Biology
Satomi Sumikawa, Shinichi Watanabe, Mamoru Tanaka, Akihiro Tanaka, Hiroaki Araki
PURPOSE: Oral mucositis is a frequent and dose-limiting side effect of radiotherapy or chemotherapy in cancer patients. We investigated the effect of basic fibroblast growth factor on radiation-induced oral mucositis in male Syrian hamsters. METHOD: Oral mucositis was induced in male Syrian hamsters by a single dose of 30-Gy irradiation. Eight days after irradiation, treatment with gel containing trafermin (basic fibroblast growth factor) at 1 µg or 10 µg up to day-21 was initiated...
October 16, 2017: International Journal of Radiation Biology
Nicholas J Rancilio, Shaun Dahl, Ilektra Athanasiadi, Carlos J Perez-Torres
PURPOSE: The goal of this study was to design a positioning device that would allow for selective irradiation of the mouse brain with a clinical linear accelerator. METHODS: We designed and fabricated an immobilization fixture that incorporates three functions: head stabilizer (through ear bars and tooth bar), gaseous anesthesia delivery and scavenging, and tissue mimic/bolus. Cohorts of five mice were irradiated such that each mouse in the cohort received a unique dose between 1000 and 3000 cGy...
October 5, 2017: International Journal of Radiation Biology
R N Sharan, Kamlesh Asotra
No abstract text is available yet for this article.
October 2, 2017: International Journal of Radiation Biology
John E Moulder, Colin Seymour
PURPOSE: Review the historical basis for the use of fractionated radiation in radiation oncology. CONCLUSION: The history of dose fractionation in radiation oncology is long and tortuous, and the radiobiologist's understanding of why fractionation worked came decades after radiation oncologists had adopted multi-week daily-dose fractionation as 'standard'. Central to the history is the search for 'isoeffective' formulas that would allow different radiation schedules to be compared...
October 2, 2017: International Journal of Radiation Biology
Susan Cheraghi, Alireza Nikoofar, Mohsen Bakhshandeh, Samideh Khoei, Saeid Farahani, Hamid Abdollahi, Seied Rabi Mahdavi
PURPOSE: The aim of this study was to generate the dose-response curves by six normal tissue complication probability (NTCP) models and ranking the models for prediction of radiation induced sensorineural hearing loss (SNHL) caused by head and neck radiation therapy (RT). METHODS AND MATERIALS: Pure tone audiometry (PTA) was performed on 70 ears of patients for 12 months after the completion of radiation therapy. The SNHL was defined as a threshold shift ≤15 dB at 2 contiguous frequencies according to the common toxicity criteria for adverse events scoring system...
October 2, 2017: International Journal of Radiation Biology
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