Read by QxMD icon Read

International Journal of Radiation Biology

Ursula Oestreicher, Daniel Samaga, Elizabeth Ainsbury, Ana Catarina Antunes, Ans Baeyens, Leonardo Barrios, Christina Beinke, Philip Beukes, William F Blakely, Alexandra Cucu, Andrea De Amicis, Julie Depuydt, Stefania De Sanctis, Marina Di Giorgio, Katalin Dobos, Inmaculada Dominguez, Pham Ngoc Duy, Marco E Espinoza, Farrah N Flegal, Markus Figel, Omar Garcia, Octávia Monteiro Gil, Eric Gregoire, C Guerrero-Carbajal, İnci Güçlü, Valeria Hadjidekova, Prakash Hande, Ulrike Kulka, Jennifer Lemon, Carita Lindholm, Florigio Lista, Katalin Lumniczky, Wilner Martinez-Lopez, Nataliya Maznyk, Roberta Meschini, Radia M'kacher, Alegria Montoro, Jayne Moquet, Mercedes Moreno, Mihaela Noditi, Jelena Pajic, Analía Radl, Michelle Ricoul, Horst Romm, Laurence Roy, Laure Sabatier, Natividad Sebastià, Jacobus Slabbert, Sylwester Sommer, Monica Stuck Oliveira, Uma Subramanian, Yumiko Suto, Tran Que, Antonella Testa, Georgia Terzoudi, Anne Vral, Ruth Wilkins, LusiYanti Yanti, Demetre Zafiropoulos, Andrzej Wojcik
PURPOSE: Two quality controlled inter-laboratory exercises were organized within the EU project 'Realizing the European Network of Biodosimetry (RENEB)' to further optimize the dicentric chromosome assay (DCA) and to identify needs for training and harmonization activities within the RENEB network. MATERIALS AND METHODS: The general study design included blood shipment, sample processing, analysis of chromosome aberrations and radiation dose assessment. After manual scoring of dicentric chromosomes in different cell numbers dose estimations and corresponding 95% confidence intervals were submitted by the participants...
October 21, 2016: International Journal of Radiation Biology
Zarko Barjaktarovic, Juliane Merl-Pham, Omid Azimzadeh, Stefan J Kempf, Ken Raj, Michael J Atkinson, Soile Tapio
PURPOSE: Ionizing radiation induces cardiovascular disease, the endothelium being the main target. The exact mechanism of the damage is unclear but the involvement of multiple signaling pathways is probable. Reversible lysine acetylation is a posttranslational protein modification that regulates activity across a broad range of signaling pathways. The aim of this study was to determine if a low radiation dose results in acetylome alteration in endothelial cells. MATERIALS AND METHODS: Human coronary artery endothelial cell line was irradiated with Cs-137 gamma-rays (0...
October 21, 2016: International Journal of Radiation Biology
Igor Koturbash, Matt Merrifield, Olga Kovalchuk
PURPOSE: While the effects of high doses of ionizing radiation (IR) are relatively well characterized, the molecular mechanisms underlying cellular responses to prolonged exposure to low doses of radiation remain largely under-investigated. MATERIALS AND METHODS: Here, we addressed the DNA damage and apoptotic response in the spleen tissue of C57BL/6 male mice after fractionated exposure to X-rays within the 0.1-0.5 Gy dose range. RESULTS: The response to initial exposure to 0...
October 19, 2016: International Journal of Radiation Biology
Ulrike Kulka, Andrzej Wojcik
No abstract text is available yet for this article.
October 17, 2016: International Journal of Radiation Biology
Georgina Royle, Nadia Falzone, Radka Chakalova, Katherine Vallis, Sverre Myhra
PURPOSE: A challenge for single-cell dosimetry of internalized Auger electron-emitting (AE) radiopharmaceuticals remains how best to elucidate their spatial distribution. To this end, a method, photoresist autoradiography (PAR), was previously developed to identify the lateral spatial distribution of AE-emitting radionuclides internalized in single cancer cells. In this paper, we present a simple mathematical model based on the radius and depth of radiation-induced patterns in photoresist material to identify the location in the z-plane of an (111)In source capable of generating the pattern...
October 17, 2016: International Journal of Radiation Biology
Charlot Vandevoorde, Julie Depuydt, Liv Veldeman, Wilfried De Neve, Natividad Sebastià, Greet Wieme, Annelot Baert, Sofie De Langhe, Jan Philippé, Hubert Thierens, Anne Vral
PURPOSE: A minority of patients exhibits severe late normal tissue toxicity after radiotherapy (RT), possibly related to their inherent individual radiation sensitivity. This study aimed to evaluate four different candidate in vitro cellular radiosensitivity assays for prediction of late normal tissue reactions, in a retrospective matched case-control set-up of breast cancer patients. METHODS: The study population consists of breast cancer patients expressing severe radiation toxicity (12 cases) and no or minimal reactions (12 controls), with a follow-up for at least 3 years...
October 17, 2016: International Journal of Radiation Biology
Hongjuan Zhang, Fang Wang, Chunjie Mao, Zuncheng Zhang, Shengjun Fu, Jianzhong Lu, Zhenxing Zhai, Renju Li, Shuwen Li, Ron Rodriguez, Zhiping Wang
PURPOSE: Gene therapy combined with radiation has shown promising potential for the treatment of tumors. This paper aimed to clarify the synergistic effect of radiotherapy combined with the bladder cancer tissue-specific oncolytic adenovirus (Ad-PSCAE-UPII-E1A) on bladder cancer cells and to study the underlying synergy mechanisms of the combined treatment. MATERIALS AND METHODS: The Adenovirus carrying E1A under control of UPII promoter and prostate stem cell antigen enhancer (PSCAE) were successfully constructed...
October 14, 2016: International Journal of Radiation Biology
François Trompier, Marion Baumann, Lleonard Barrios, Eric Gregoire, Michael Abend, Elizabeth Ainsbury, Stephen Barnard, Joan Francesc Barquinero, Juan Antonio Bautista, Beata Brzozowska, Jose Perez-Calatayud, Cinzia De Angelis, Inmaculada Domínguez, Valeria Hadjidekova, Ulrike Kulka, Juan Carlos Mateos, Roberta Meschini, Octávia Monteiro Gil, Jayne Moquet, Ursula Oestreicher, Alegria Montoro Pastor, Roel Quintens, Natividad Sebastià, Sylwester Sommer, Orlin Stoyanov, Hubert Thierens, Georgia Terzoudi, Juan Ignacio Villaescusa, Anne Vral, Andrzej Wojcik, Demetre Zafiropoulos, Laurence Roy
PURPOSE: In the frame of the QA program of RENEB, an inter-laboratory comparison (ILC) of calibration sources used in biological dosimetry was achieved to investigate the influence of calibration practices and protocols on the results of the dose estimation performance as a first step to harmonization and standardization of dosimetry and irradiation practices in the European biological dosimetry network. MATERIALS AND METHODS: Delivered doses by irradiation facilities used by RENEB partners were determined with EPR/alanine dosimetry system...
October 13, 2016: International Journal of Radiation Biology
Min Liu, Hongyan Wang, Solah Lee, Bailong Liu, Lihua Dong, Ya Wang
PURPOSE: To clarify which DNA double-strand break repair pathway, non-homologous end-joining (NHEJ), homologous recombination repair (HRR) or both, plays a key role in potentially lethal damage repair (PLDR). METHODS AND MATERIALS: Combining published data and our new potentially lethal damage repair (PLDR) data, we explain whether similar to sublethal damage repair (SLDR), PLDR also mainly depends on NHEJ versus HRR. The PLDR data used the same cell lines: wild type, HRR or NHEJ-deficient fibroblast cells, as those SLDR data published by our laboratory previously...
October 13, 2016: International Journal of Radiation Biology
Junko Takahashi, Masaki Misawa, Hitoshi Iwahashi
PURPOSE: 5-Aminolevulinic acid (ALA) is a precursor of the photosensitizer protoporphyrin (PpIX) used in photodynamic therapy. In our previous work, PpIX enhanced the generation of reactive oxygen species by X-ray irradiation. In this study, we evaluated the potential of ALA as an endogenous sensitizer to X-ray irradiation. METHODOLOGY: Tumor-bearing C57BL/6J mice implanted with B16-BL6 melanoma cells were subsequently treated with irradiation (3 Gy/day for 10 days; total, 30 Gy) plus local administration of 50 mg/kg ALA 24 hours prior to each irradiation (ALA-XT)...
October 12, 2016: International Journal of Radiation Biology
Wei Lu, Ke Wu, Xiangjun Hu, Xiangdong Xie, Jing Ning, Changzhen Wang, Hongmei Zhou, Guoshan Yang
PURPOSE: Intracellular electroporation occurs when the cells are exposed to nanosecond pulsed electric field (nsPEF). It is believed the electroporation (formation and extension of pores on the membrane induced by external electric field) is affected significantly by the transmembrane potential. This paper analyzed transmembrane potential induced by nsPEF in the term of pulse frequency spectrum, aiming to provide a theoretical explanation to intracellular bio-effects. METHODS: Based on the double-shelled spherical cell model, the frequency dependence of transmembrane potential was obtained by solving Laplace's equation, while the time course of transmembrane potential was obtained by a method combined with discrete Fourier transform and Laplace transform...
October 10, 2016: International Journal of Radiation Biology
Robson B Freitas, Paquita González, Nara Maria B Martins, Edson R Andrade, María Jesús Cesteros Morante, Iban Conles Picos, Serafín Costilla García, Liliane F Bauermann, Juan Pablo Barrio
PURPOSE: Whole brain irradiation (WBI) causes a variety of secondary side-effects including anorexia and bone necrosis. We evaluated the radiomodifying effect of black grape juice (BGJ) on WBI alterations in rats measuring food and water intake, body weight, hemogram, and morphological and histological mandibular parameters. MATERIALS AND METHODS: Forty male rats (200-250 g) were exposed to eight sessions of cranial X-ray irradiation. The total dose absorbed was 32 Gy delivered over 2 weeks...
October 7, 2016: International Journal of Radiation Biology
Ulrike Kulka, Michael Abend, Elizabeth Ainsbury, Christophe Badie, Joan Francesc Barquinero, Lleonard Barrios, Christina Beinke, Emanuela Bortolin, Alexandra Cucu, Andrea De Amicis, Inmaculada Domínguez, Paola Fattibene, Anne Marie Frøvig, Eric Gregoire, Kamile Guogyte, Valeria Hadjidekova, Alicja Jaworska, Ralf Kriehuber, Carita Lindholm, David Lloyd, Katalin Lumniczky, Fiona Lyng, Roberta Meschini, Simone Mörtl, Sara Della Monaca, Octávia Monteiro Gil, Alegria Montoro, Jayne Moquet, Mercedes Moreno, Ursula Oestreicher, Fabrizio Palitti, Gabriel Pantelias, Clarice Patrono, Laure Piqueret-Stephan, Matthias Port, María Jesus Prieto, Roel Quintens, Michelle Ricoul, Horst Romm, Laurence Roy, Géza Sáfrány, Laure Sabatier, Natividad Sebastià, Sylwester Sommer, Georgia Terzoudi, Antonella Testa, Hubert Thierens, Istvan Turai, François Trompier, Marco Valente, Pedro Vaz, Philippe Voisin, Anne Vral, Clemens Woda, Demetre Zafiropoulos, Andrzej Wojcik
PURPOSE: A European network was initiated in 2012 by 23 partners from 16 European countries with the aim to significantly increase individualized dose reconstruction in case of large-scale radiological emergency scenarios. RESULTS: The network was built on three complementary pillars: (1) an operational basis with seven biological and physical dosimetric assays in ready-to-use mode, (2) a basis for education, training and quality assurance, and (3) a basis for further network development regarding new techniques and members...
October 6, 2016: International Journal of Radiation Biology
Shin-Ichi Bando, Osamu Hatano, Hiroshi Takemori, Nobuo Kubota, Ken Ohnishi
PURPOSE: This study examined the enhancing effects of syringetin on the radiosensitivity of normal and cancer cells, and the related mechanism. MATERIALS AND METHODS: We used normal human lung and mouse fibroblasts as well as human lung and mouse cancer cells derived from the above normal fibroblasts. Cell radiosensitivity was measured using a colony formation assay. Apoptosis was analyzed with DAPI staining and Western blots. DNA lesions were analyzed with γH2AX immunofluorescent staining...
October 6, 2016: International Journal of Radiation Biology
Iyo Shiraishi, Naoya Shikazono, Masao Suzuki, Kentaro Fujii, Akinari Yokoya
PURPOSE: To clarify whether initial base excision repair processes at clustered DNA damage sites comprising multiple base lesions affect subsequent excision processes via the formation of additional strand breaks by glycosylase and apurinic/apyrimidinic (AP) endonuclease base excision enzymes. MATERIALS AND METHODS: Plasmid DNA (pUC18) as a model DNA molecule was exposed to high-linear-energy-transfer (LET) ionizing radiation (He(2+) or C(6+) ions) or low-LET ionizing radiation (X-rays) under various conditions to produce varied radical-scavenging effects...
October 6, 2016: International Journal of Radiation Biology
Mehdi Mousavi, Hassan Ali Nedaei, Samideh Khoei, Samira Eynali, Karim Khoshgard, Mostafa Robatjazi, Rasoul Iraji Rad
PURPOSE: Gold nanoparticles (GNP) have significant potential as radiosensitizer agents due to their distinctive properties. Several studies have shown that the surface modification of nanoparticles with methyl polyethylene glycol (mPEG) can increase their biocompatibility. However, the present study investigated the radiosensitization effects of mPEG-coated GNP (mPEG-GNP) in B16F10 murine melanoma cells under irradiation of 6 MeV Electron beam. MATERIALS AND METHODS: The synthesized GNP were characterized by UV-Visible spectroscopy, dynamic light scattering, transmission electron microscopy, and zeta potential...
October 5, 2016: International Journal of Radiation Biology
Joan Francesc Barquinero, Christina Beinke, Mireia Borràs, Iwona Buraczewska, Firouz Darroudi, Eric Gregoire, Rositsa Hristova, Ulrike Kulka, Carita Lindholm, Mercedes Moreno, Jayne Moquet, Ursula Oestreicher, M Jesús Prieto, Mònica Pujol, Michelle Ricoul, Laure Sabatier, Sylwester Sommer, Mingzhu Sun, Andrzej Wojcik, Leonardo Barrios
PURPOSE: In the framework of RENEB, several biodosimetry exercises were conducted analyzing different endpoints. Among them, the analysis of translocations is considered the most useful method for retrospective biodosimetry due to the relative stability of their frequency with post irradiation time. The aim of this study was to harmonize the accuracy of translocation-based biodosimetry within the RENEB consortium. MATERIALS AND METHODS: An initial telescoring exercise analyzing FISH metaphase images was done to harmonize chromosome aberration descriptions...
October 5, 2016: International Journal of Radiation Biology
Jukka Luukkonen, Anne Höytö, Miiko Sokka, Anu Liimatainen, Juhani Syväoja, Jukka Juutilainen, Jonne Naarala
PURPOSE: In our previous studies, exposure to extremely low frequency (ELF) magnetic fields (MF) altered responses to DNA damage caused by menadione. The aim of this study was to evaluate possible ELF MF induced changes in proteins involved in DNA damage responses and in cell cycle distribution. MATERIALS AND METHODS: Based on our previous studies, the exposure protocol included pre-exposure of human SH-SY5Y neuroblastoma cells to a 50 Hz, 100 μT MF for 24 h prior to a 3-h menadione treatment...
October 5, 2016: International Journal of Radiation Biology
Octávia Monteiro Gil, Pedro Vaz, Horst Romm, Cinzia De Angelis, Ana Catarina Antunes, Joan-Francesc Barquinero, Christina Beinke, Emanuela Bortolin, Christopher Ian Burbidge, Alexandra Cucu, Sara Della Monaca, Mercedes Moreno Domene, Paola Fattibene, Eric Gregoire, Valeria Hadjidekova, Ulrike Kulka, Carita Lindholm, Roberta Meschini, Radhia M'Kacher, Jayne Moquet, Ursula Oestreicher, Fabrizio Palitti, Gabriel Pantelias, Alegria Montoro Pastor, Irina-Anca Popescu, Maria Cristina Quattrini, Michelle Ricoul, Kai Rothkamm, Laure Sabatier, Natividad Sebastià, Sylwester Sommer, Georgia Terzoudi, Antonella Testa, François Trompier, Anne Vral
PURPOSE: To identify and assess, among the participants in the RENEB (Realizing the European Network of Biodosimetry) project, the emergency preparedness, response capabilities and resources that can be deployed in the event of a radiological or nuclear accident/incident affecting a large number of individuals. These capabilities include available biodosimetry techniques, infrastructure, human resources (existing trained staff), financial and organizational resources (including the role of national contact points and their articulation with other stakeholders in emergency response) as well as robust quality control/assurance systems...
October 4, 2016: International Journal of Radiation Biology
Alihossein Saberi, Daryoush Shahbazi-Gahrouei, Mahdi Abbasian, Mehrafarin Fesharaki, Azam Baharlouei, Zahra Arab-Bafrani
PURPOSE: Gold nanoparticles (GNPs) act as a radiosensitizer in radiation therapy. However, recent studies have shown contradictory evidence in terms of radiosensitization in the presence of GNPs combined with x-ray megavoltage energy (MV) on different cell types. In this study, the effect of GNPs on radiosensitization enhancement of HT-29 human colorectal cancer cells at MV x-ray energy was evaluated. MATERIAL AND METHODS: The cytotoxicity and radiosensitization of GNPs were evaluated in HT-29 human colorectal cancer cells by MTS-assay and multiple MTS-assay, respectively...
October 3, 2016: International Journal of Radiation Biology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"