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International Journal of Radiation Biology

Abdulhamid Chaikh, Valentin Calugaru, Pierre-Yves Bondiau, Juliette Thariat, Jacques Balosso
PURPOSE: The aim of this study is to evaluate the impact of normal tissue complication probability (NTCP)-based radiobiological models on the estimated risk for late radiation lung damages. The second goal is to propose a medical decision-making approach to select the eligible patient for particle therapy. MATERIALS AND METHODS: Fourteen pediatric patients undergoing cranio-spinal irradiation were evaluated. For each patient, two treatment plans were generated using photon and proton therapy with the same dose prescriptions...
July 16, 2018: International Journal of Radiation Biology
Parisa Rezaie, Samideh Khoei, Sepideh Khoee, Sakine Shirvalilou, Seied Rabi Mahdavi
PURPOSE: Glioblastoma multiform (GBM) is the most prevalent and aggressive type of primary brain tumor. None of the current conventional treatment methods has improved treatment considerably. Therefore, in this study the effect of magnetic nanoparticles coated with poly (caprolactone)-poly (ethylene glycol) (PCL-PEG) as a 5-iodo 2'deoxyuridine (IUdR) carrier in the presence of hyperthermia and 6 MV (megavoltage) X-ray radiation, were investigated in a spheroid model of U87MG glioblastoma cell line using colony formation assay...
July 9, 2018: International Journal of Radiation Biology
Nadia Abdel-Magied, Amal A Gharib, Nahed Abo Zid
PURPOSE: To evaluate the radioprotective efficacy of date (Phoenix dactylifera) pits extract (DPE) against γ-irradiation induced liver damage in the male albino rats. For this study, 30-day survival, dose reduction factor (DRF), antioxidant status and some biochemical changes in the serum and hepatic tissue were evaluated. MATERIAL AND METHODS: To calculate 30-day survival, median lethal dose of 30 days (LD50/30) and DRF, DPE was orally administered to rats for 21 days before irradiation with different doses (5, 6, 8, 10 and 12 Gy) of γ-rays and the rats were observed for 30 days post- irradiation...
July 3, 2018: International Journal of Radiation Biology
Hamid Abdollahi, Seied Rabi Mahdavi, Bahram Mofid, Mohsen Bakhshandeh, Abolfazl Razzaghdoust, Afshin Sadipour, Kiarash Tanha
PURPOSE: To investigate MRI radiomic analysis to assess IMRT associated rectal wall changes and also for predicting radiotherapy induced rectal toxicity. MATERIAL AND METHODS: At first, a machine learning radiomic analysis was applied on T2 weighted (T2W) and apparent diffusion coefficient (ADC) rectal wall MR images of prostate cancer patients' pre and post-IMRT to predict rectal toxicity. Next, Wilcoxon singed rank-test was performed to find radiomic features with significant changes pre-post-IMRT...
July 3, 2018: International Journal of Radiation Biology
Stéphane Grison, Ghada Elmhiri, Céline Gloaguen, Christelle Elie, Dimitri Kereselidze, Karine Tack, Philippe Lestaevel, Audrey Legendre, Line Manens, Mohamed Amine Benadjaoud, Jean-Marc Lobaccaro, Maâmar Souidi
PURPOSE: A protocol of chronic exposure to low dose of uranium was established in order to distinguish the sexual differences and the developmental process that are critical windows for epigenetic effects over generations. METHODS: Both male and female rats were contaminated through their drinking water with a non-toxic solution of uranyl nitrate for nine months. The exposed generation (F0) and the two following generations (F1 and F2) were examined. Clinical monitoring, global DNA methylation profile and DNA methyltransferases (DNMTs) gene expression were analyzed in kidneys...
July 2, 2018: International Journal of Radiation Biology
Al Maqsudur Rashid, Latha Ramalingam, Arwa Al-Jawadi, Naima Moustaid-Moussa, Hanna Moussa
PURPOSE: Recently, new studies have brought to light the potential risks of low dose radiation (LDR) in cancer. In this review, we discuss in detail the detrimental effects of LDR in some model organisms and animal models, as well as potential risks to human beings from some routine medical screening procedures. Furthermore, cellular mechanisms by which LDR exerts its negative effects like endoplasmic reticulum stress, epigenetic changes and microRNAs are also reviewed. A few studies are discussed that have reported some benefits of LDR through changes in energy metabolism...
July 2, 2018: International Journal of Radiation Biology
I O Velegzhaninov, A V Ermakova, D Y Klokov
PURPOSE: Exposure to high dose ionizing radiation leads to premature cell senescence and suppression of cell proliferation. In contrast, low dose and low dose-rate gamma-irradiation can lead to stimulation of cell proliferation. We aimed to examine whether the low dose radiation-induced proliferation of normal human fibroblasts can lead to a progressive depletion of proliferation potential and to an early onset of senescence. MATERIALS AND METHODS: Normal human embryonic lung fibroblasts (HELF-104) at passage 22-24 were gamma-irradiated with doses of 0 (sham-irradiation), 10, 30, 50, 90, 120, 150, 200, 500 mGy as well as 1 and 2 Gy...
June 28, 2018: International Journal of Radiation Biology
Nitin Motilal Gandhi
PURPOSE: Cellular damage due to low dose of γ-radiation (≤0.1 Gy) is generally extrapolated from observing the effects at higher doses. These estimations are not accurate. This has led to uncertainties while assessing the radiation risk factors at low doses. Although there are reports on the radiation induced adaptive response, the mechanism of action is not fully elucidated, leading to the uncertainties. One of the outcomes of low dose radiation exposure is believed to be adaptive response...
June 26, 2018: International Journal of Radiation Biology
F T J Santos, W N Siqueira, M L O Santos, H A M F Silva, J L F Sá, T S Fernandes, N H Silva, E J França, E B Silva, A M M A Melo
PURPOSE: Some phytochemicals have shown the potential of being radiomodifiers, especially phenolic compounds, such as lichenic secondary metabolites. To evaluate the phytochemical usnic acid as a radiomodifier, embryonic cells of molluscs have been used due to their ease of collection, high sensitivity to physical and chemical agents, well-known embryology and low cost for analysis. MATERIALS AND METHODS: This study aimed to assess the radiosensitizing action of usnic acid on Biomphalaria glabrata embryos...
June 25, 2018: International Journal of Radiation Biology
Mohamed A El-Missiry, Azza I Othman, Mamdouh R El-Sawy, Mohamad F Lebede
PURPOSE: The present study investigated the potential neuroprotective effect of epigallocatechin-3-gallate (EGCG) on radiation-induced cell death and damage in the hippocampus. MATERIALS AND METHODS: Adult male Wister rats received oral treatment with EGCG at doses of 2.5 and 5 mg/kg/day for 3 days before 4 Gy γ irradiation. RESULTS: The pretreatment of irradiated rats with EGCG significantly ameliorated the increased plasma levels of homocysteine, amyloid β, TNF-α and IL-6 levels and the decrease of dopamine and serotonin...
June 25, 2018: International Journal of Radiation Biology
Enis Hidisoglu, Deniz Kantar-Gok, Sukru Ozen, Piraye Yargicoglu
PURPOSE: There is a growing interest in usage of radiofrequency radiation (RF) as a noninvasive brain stimulation method. Previous reported data demonstrated that RF exposure caused a change in brain oscillations. Therefore, we aimed to investigate effects of RF on brain oscillation by measuring auditory response of different brain regions in rats. Material Methods: Rats were randomly divided into three groups (n = 12 per each group): Cage control (C), sham rats (Sh), and rats exposed to 2...
June 25, 2018: International Journal of Radiation Biology
Melis Karabulutoglu, Rosemary Finnon, Tatsuhiko Imaoka, Anna A Friedl, Christophe Badie
PURPOSE: The review aims to discuss the prominence of dietary and metabolic regulators in maintaining HSC function, long-term self-renewal and differentiation. RESULTS: Most adult stem cells are preserved in a quiescent, non-motile state in vivo which acts as a "protective state" for stem cells to reduce endogenous stress provoked by DNA replication and cellular respiration as well as exogenous environmental stress. The dynamic balance between quiescence, self-renewal and differentiation is critical for supporting a functional blood system throughout life of an organism...
June 22, 2018: International Journal of Radiation Biology
Ville Jäntti, Tuomo Ylinen, Narayan Puthanmadam Subramaniyam, Kotoe Kamata, Arvi Yli-Hankala, Pasi Kauppinen, Eila Sonkajärvi
PURPOSE: Anesthesiologists have increasingly started to use EEG-based indexes to estimate the level and type of unconsciousness. However, the physiology and biophysics are poorly understood in anesthesiological literature. METHODS: EEG was recorded from electrodes on the surface of head, including scalp, as well as DBS (deep brain stimulation) electrodes implanted deep in the brain. Mathematical modeling with a realistic head model was performed to create illustrative images of the sensitivity of electrode montages...
June 22, 2018: International Journal of Radiation Biology
Maie Bachmann, Laura Päeske, Andreas A Ioannides, Jaanus Lass, Hiie Hinrikus
PURPOSE: This feasibility study is aimed to clarify the possibility of detection of microwave radiation (MWR)-induced event related potential (ERP) in electroencephalographic (EEG) signal. METHODS: To trigger onset and offset effects in EEG, repetitive MWR stimuli were used. Four 30-channel EEG recordings on a single subject were performed, each about one month apart. The subject was exposed to 450 MHz MWR modulated at 40 Hz at the 1 g peak spatial average specific absorption rate of 0...
June 20, 2018: International Journal of Radiation Biology
Marcos Tassano, Natalia Oddone, Marcelo Fernández, Williams Porcal, María Fernanda García, Wilner Martínez-López, Juan Claudio Benech, Pablo Cabral
PURPOSE: To study the rhenium-188 labeling of polyamidoamine (PAMAM) generation 4 (G4) dendrimer and its evaluation on biodistribution and chromosomal aberrations in melanoma cells induced by ionizing radiation as potential treatment agent. MATERIALS AND METHODS: Dendrimers were first conjugated with Suc-HYNIC (succinimidyl 6-hydrazinopyridine-3-carboxylic acid hydrochloride). Dendrimer-HYNIC was then incubated with 188 ReO4 - . Biodistribution was performed administrating 188 Re-dendrimer to normal (NM) or melanoma-bearing mice (MBM)...
June 19, 2018: International Journal of Radiation Biology
Valentina Pinzi, Ilaria Bisogno, Francesco Prada, Emilio Ciusani, Laura Fariselli
PURPOSE: Meningiomas account for one third of primary intracranial tumors; nevertheless information on meningioma cell lines and in vivo models is scant. Although radiotherapy is one of the most relevant therapeutic options for the treatment of patients with meningioma, radiobiological research to understand tumor response to this treatment is far from being thoroughly figured out. The aim of this report is to provide a comprehensive picture of the current literature on this field, so as to foster research in this regard...
June 19, 2018: International Journal of Radiation Biology
Poushali Bhattacharya, Neena G Shetake, Badri N Pandey, Amit Kumar
PURPOSE: One of the most important implications of 'Radiation Biology' research is to improve cancer radiotherapy with minimum side effects. In this regard, combination of chemotherapy with radiation has significantly improved tumor control as well as overall survival in a variety of cancers. However, this has been achieved at the cost of significant normal tissue toxicity, due to the lack of specificity of chemotherapy. Membrane-localized receptor tyrosine kinases (RTKs) have been found to play a driving role in various hallmarks of cancer...
June 19, 2018: International Journal of Radiation Biology
Ki Moon Seong, TaeWoo Kwon, Jina Park, BuHyun Youn, Hyuk-Jin Cha, Yonghwan Kim, Changjong Moon, Seung-Sook Lee, Young Woo Jin
PURPOSE: Since the 2011 Fukushima nuclear power plant accident, Korean radiation experts have agreed that reliable data on health risks of low-dose radiation (LDR) are needed to ease the anxiety of lay people. The intent of this study was to devise a sustainable biological program suited for the research environment in Korea and aimed at the health effects of radiation exposures <100 millisieverts (mSv). To address pressing public concerns over LDR risk, we investigated the current understanding of LDR effects by analyzing the previous reports of international authorities for radiation protection and research publications that appeared after the Chernobyl accident...
June 19, 2018: International Journal of Radiation Biology
Ahmed I Hasaballah
PURPOSE: The aim was to evaluate the effects of irradiation of Culex pipiens irradiated as pupae on the larval and pupal mortality percentages, the larval and pupal duration, adult emergence percentages and ovarian development in comparison with the un-irradiated group. MATERIAL AND METHODS: the mosquito, C. pipiens Linnaeus (L) was irradiated as pupae with three gamma doses 40, 60 and 80 Gy. Different biological aspects include the ovarian development of irradiated females tested...
June 18, 2018: International Journal of Radiation Biology
Ali Masoumi, Narges Karbalaei, S M J Mortazavi, Mohammad Shabani
PURPOSE: There is a great concern regarding the possible adverse effects of electromagnetic radiation (EMR). This study investigated the effects of EMR induced by Wi-Fi (2.45GHz) on insulin secretion and antioxidant redox systems in the rat pancreas. MATERIALS AND METHODS: Adult male Sprague-Dawley rats in the weight range of 230 to 260 g were divided into control, sham, Wi-Fi exposed groups. After long term exposure (4 h/day for 45 days) to Wi-Fi electromagnetic radiation, plasma levels of glucose and insulin during intraperitoneal glucose tolerance test were measured...
June 18, 2018: International Journal of Radiation Biology
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