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International Journal of Radiation Biology

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https://www.readbyqxmd.com/read/27910734/targeting-the-akt-cyclin-d1-pathway-to-overcome-intrinsic-and-acquired-radioresistance-of-tumors-for-effective-radiotherapy
#1
Tsutomu Shimura
PURPOSE: Radiotherapy (RT) is a powerful tool in the treatment of cancer, having the advantage of preserving normal tissues. Clinical outcomes of RT are significantly improved by technological advances, enabling increased radiation doses directed very specifically to a tumor. However, tumor radioresistance remains a major impediment to effective RT. We have shown that human tumor cells surviving after repeated exposure to fractionated radiation (FR) of X-rays for 1 month have acquired radioresistance through constitutive activation of AKT and downstream cyclin D1 nuclear retention...
December 2, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27899034/ionizing-radiation-sensitivity-of-the-ocular-lens-and-its-dose-rate-dependence
#2
Nobuyuki Hamada
PURPOSE: In 2011, the International Commission on Radiological Protection reduced the threshold for the lens effects of low linear energy transfer (LET) radiation. On one hand, the revised threshold of 0.5 Gy is much lower than previously recommended thresholds, but mechanisms behind high radiosensitivity remain incompletely understood. On the other hand, such threshold is independent of dose rate, in contrast to previously recommended separate thresholds each for single and fractionated/protracted exposures...
November 30, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27897091/inducing-mutations-through-%C3%AE-irradiation-in-seeds-of-mucuna-pruriens-for-developing-high-l-dopa-yielding-genotypes
#3
Susheel Kumar Singh, Deepti Yadav, Raj Kishori Lal, Madan M Gupta, Sunita Singh Dhawan
PURPOSE: To develop elite genotypes in Mucuna pruriens (L.) DC with high L-DOPA (L-3, 4 dihydroxyphenylalanine) yields, with non-itching characteristics and better adaptability by applying γ-irradiation. Molecular and chemical analysis was performed for screening based on specific characteristics desired for developing suitable genotypes. MATERIALS AND METHODS: Developed, mutant populations were analyzed for L-DOPA % in seeds through TLC (thin layer chromatography), and the results obtained were validated with the HPLC (High performance liquid chromatography)...
November 29, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27892758/gamma-radiation-tolerance-in-different-life-stages-of-the-fruit-fly-drosophila-melanogaster
#4
Jagdish Gopal Paithankar, K Deeksha, Rajashekhar K Patil
PURPOSE: Insects are known to have high levels of radiation tolerance than mammals. The fruit fly, Drosophila provides opportunities for genetic analysis of radiation tolerance in insects. A knowledge of stage-specific sensitivity is required to understand the mechanisms and test the existing hypothesis of insect radiation tolerance. MATERIALS AND METHODS: Drosophila melanogaster were irradiated using gamma rays at different life stages. Irradiation doses were chosen to start from 100 Gy to 2200 Gy with increments of 100 Gy, with a dose rate of 12...
November 28, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27778529/residential-radon-and-copd-an-ecological-study-in-galicia-spain
#5
Raquel Barbosa-Lorenzo, Alberto Ruano-Ravina, Rebeca Ramis, Nuria Aragonés, Karl T Kelsey, Consuelo Carballeira-Roca, Alberto Fernández-Villar, Gonzalo López-Abente, Juan M Barros-Dios
PURPOSE: Radon is a human lung carcinogen but it might be linked with other respiratory diseases. We aimed to assess the relationship between residential radon exposure and COPD (chronic obstructive pulmonary disease) prevalence and hospital admissions at a municipal level. MATERIALS AND METHODS: We designed an ecological study where we included those municipalities with at least three radon measurements. Using mixed Poisson regression models, we calculated the relative risk (RR) for COPD for each 100 Bq/m(3) of increase in radon concentration and also the relative risk for COPD using a cut-off point of 50 Bq/m(3)...
November 17, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27834112/restorative-role-of-persimmon-leaf-diospyros-kaki-to-gamma-irradiation-induced-oxidative-stress-and-tissue-injury-in-rats
#6
Omaima M Ashry, Elham M Hussein, Afrag Sh Abd El-Azime
PURPOSE: This study tends to evaluate the efficacy of persimmon leaf extract) PL (as a rich plant source in modulation of radiation induced liver injury and some metabolic variations in gamma irradiated rats. MATERIAL AND METHODS: PL at the dose of 1000 mg/kg body weight (P1000) was administered to male albino rats via gastric intubation for 15 days after whole body γ- irradiation (6Gy). RESULTS: Irradiated rats showed significant decreases in hepatic glutathione content (GSH), superoxide dismutase (SOD), catalase (CAT) and xanthine dehydrogenase (XDH) activities with significant increases in malondialdehyde (MDA) level and xanthine oxidase (XO) activity designating oxidative stress...
November 11, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27834104/upregulating-dab2ip-expression-via-egr-1-inhibition-a-new-approach-for-overcoming-fractionated-irradiation-induced-cross-tolerance-to-ionizing-radiation-and-mitomycin-c-in-tumor-cells
#7
Rulve Chang, Hui He, Guangmin Mao, Zhaolu Kong
PURPOSE: In this study, we evaluated the effect of fractionated irradiation (FI) on tumor cells sensitivity to ionizing radiation (IR) and antineoplastic drugs, and examined the potential of early growth response-1 (EGR-1) inhibition to sensitize tumor cells to IR. MATERIALS AND METHODS: PC3 and HepG2 cells were subjected to γ-rays at 2 Gy for ten times. Survived cells were named PC3/R and HepG2/R, respectively. Cells sensitivity to irradiation and chemotherapeutic drugs, including cisplatin (PT), doxorubicin (DOX), mitomycin C (MMC) and 5-fluorouracil (5-FU) were identified by colony formation assay and MMT method, respectively...
November 11, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27827272/the-inhibitory-effect-of-meadowsweet-filipendula-ulmaria-on-radiation-induced-carcinogenesis-in-rats
#8
Vladimir G Bespalov, Valery A Alexandrov, Alexandr L Semenov, Elena G Kovan'ko, Sergey D Ivanov, Galina I Vysochina, Vera А Kostikova, Denis A Baranenko
PURPOSE: To examine the ability of the meadowsweet preparation to inhibit carcinogenesis induced by ionizing radiation in female rats. MATERIALS AND METHODS: The chemical composition of meadowsweet (Filipendula ulmaria) raw material (ethanol and aqueous extracts of meadowsweet flowers) has been studied for the presence of flavonoids, tannins and catechins. In animal experiments adult female LIO strain rats were subjected to a single whole body γ-irradiation at a dose of 4 Gy...
November 9, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27827005/injectable-gossypol-loaded-pluronic-p85-micelles-for-cancer-chemoradiotherapy
#9
Keishiro Tomoda, Hsin C Chiang, Kevin R Kozak, Glen S Kwon
PURPOSE: The goal of tumor-specific chemoradiotherapy is to achieve synergistic anticancer effects with clinically acceptable toxicity. Our previous studies showed that Pluronic P85 augments radiation cancer cell killing of (±)-gossypol in vitro. In this study, radiosensitizing effect of (-)-gossypol, more potent Bcl protein inhibitor, with Pluronic P85 was investigated. MATERIALS AND METHODS: The inhibitory effect of (-)-gossypol solubilized Pluronic P85 with 0-8 Gy of radiation on clonogenic survival rate of A549 human lung adenocarcinoma cells was investigated in vitro...
November 9, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27822977/corrigendum
#10
(no author information available yet)
No abstract text is available yet for this article.
November 8, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27807995/the-withers-archive-online-availability-of-h-rodney-withers-data
#11
Howard D Thames, Nancy R Hunter, Kathryn A Mason
We have collected lab notebooks from Rod Wither's many years of experimentation, from laboratories in Houston and Los Angeles, as well as from several of his collaborators in the USA and overseas. The contents have been digitized, and in this note we explain the mechanism that has been set up to make the 'Withers Archive' available online.
November 8, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27813725/dose-assessment-intercomparisons-within-the-reneb-network-using-g0-lymphocyte-prematurely-condensed-chromosomes-pcc-assay
#12
Georgia I Terzoudi, Gabriel Pantelias, Firouz Darroudi, Katarzyna Barszczewska, Iwona Buraczewska, Julie Depuydt, Dimka Georgieva, Valeria Hadjidekova, Vasiliki I Hatzi, Ioanna Karachristou, Maria Karakosta, Roberta Meschini, Radhia M'Kacher, Alegria Montoro, Fabrizio Palitti, Antonio Pantelias, Gaetano Pepe, Michelle Ricoul, Laure Sabatier, Natividad Sebastià, Sylwester Sommer, Anne Vral, Demetre Zafiropoulos, Andrzej Wojcik
PURPOSE: Dose assessment intercomparisons within the RENEB network were performed for triage biodosimetry analyzing G0-lymphocyte PCC for harmonization, standardization and optimization of the PCC assay. MATERIALS AND METHODS: Comparative analysis among different partners for dose assessment included shipment of PCC-slides and captured images to construct dose-response curves for up to 6 Gy γ-rays. Accident simulation exercises were performed to assess the suitability of the PCC assay by detecting speed of analysis and minimum number of cells required for categorization of potentially exposed individuals...
November 4, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27813704/temporal-variability-of-the-quality-of-taraxacum-officinale-seed-progeny-from-the-east-ural-radioactive-trace-is-there-an-interaction-between-low-level-radiation-and-weather-conditions
#13
Vera N Pozolotina, Elena V Antonova
Hypothesis The multiple stressors, in different combinations, may impact differently upon seed quality, and low-level doses of radiation may enhance synergistic or antagonistic effects. Results During 1991-2014 we investigated the quality of the dandelion (Taraxacum officinale s.l.) seed progeny growing under low-level radiation exposure at the East-Ural Radioactive Trace (EURT) area (result of the Kyshtym accident, Russia), and in plants from areas exposed to background radiation. The viability of the dandelion seed progeny was assessed according to chronic radiation exposure, accounting for the variability of weather conditions among years...
November 4, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27813697/radioprotective-effect-of-green-tea-and-grape-seed-extracts-mixture-on-gamma-irradiation-induced-immune-suppression-in-male-albino-rats
#14
W El-Desouky, A H Mahmoud, M M Abbas
: Green tea extract (GTE) and grape seed extract (GSE) have antioxidant and radioprotective effects. The current study aimed to investigate the radioprotective effect of GTE and GSE mixture on radiation induced immune suppression in rats. METHOD: 35 male albino rats were divided into five groups: group 1 (control rats). The 2(nd) and 3(rd) groups rats were exposed to a single dose of gamma radiation (5 and 10Gy) respectively. The 4(th) and 5(th) groups of rats were gamma irradiated with 5 and 10Gy respectively, then administrated by gavage with GTE and GSE mixture (100 mg: 200 mg/kg B...
November 4, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27809636/apoptosis-inducing-factor-aif-nuclear-translocation-mediated-caspase-independent-mechanism-involves-in-x-ray-induced-mcf-7-cell-death
#15
Shana Yang, Jianrong Huang, Pan Liu, Jianhua Li, Shenting Zhao
PURPOSE: Breast cancer is the most common cancer among women and radiotherapy is a conventional therapy following surgery. Previous studies have demonstrated that except the caspase-dependent pathway, caspase-independent pathway is also involved in the cell death responding to irradiation, despite the unclear mechanism. The purpose of the present study is to observe the role of apoptosis-inducing factor (AIF), the first identified caspase-independent molecule, in X-ray induced breast cancer cell (MCF-7) cell death...
November 4, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27807992/radiation-induced-surge-of-macrophage-foam-cell-formation-oxidative-damage-and-cytokine-release-is-attenuated-by-a-nanoformulation-of-curcumin
#16
Behrooz Soltani, Narges Bodaghabadi, Nasser Ghaemi, Majid Sadeghizadeh
PURPOSE: We examined the potential of a dendrosomal nanoformulation of curcumin (DNC) for intervention of ionizing radiation (IR)-induced damage (particularly leading to atherosclerosis), employing an irradiated THP-1 macrophage model. MATERIALS AND METHODS: Differentiated THP-1 macrophages were irradiated and treated with curcumin or DNC nanoformulation (and oxidized low density lipoprotein, ox-LDL, to promote foam cells). Chemical, biochemical, and genetics tools including viability and apoptosis, multiple ELISA, real-time PCR, Western blotting, enzyme activity, and fluorimetry assays were employed to illustrate IR damage as well as the DNC intervention potential...
November 3, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27805454/ferulic-acid-fa-abrogates-ionizing-radiation-induced-oxidative-damage-in-murine-spleen
#17
Ujjal Das, Sushobhan Biswas, Aaveri Sengupta, Krishnendu Manna, Anindita Chakraborty, Sanjit Dey
PURPOSE: Spleen is a crucial organ manifesting immune functions. Thus, radiation induced oxidative challenge is vulnerable for spleen. Our major objective was to protect the spleen from radiation induced anomalous situations and to identify the signaling pathways involved. MATERIALS AND METHODS: Swiss albino mice were treated with ferulic acid (FA) once in a day at a dose of 50 mg/kg body weight for 5 consecutive days before exposing them to single dose of 10 Gy irradiation...
November 2, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27778526/the-reneb-operational-basis-complement-of-established-biodosimetric-assays
#18
Andrzej Wojcik, Ursula Oestreicher, Lleonard Barrios, Anne Vral, Georgia Terzoudi, Elizabeth Ainsbury, Kai Rothkamm, Francois Trompier, Ulrike Kulka
PURPOSE: To set up an operational basis of the Realizing the European Network of Biodosimetry (RENEB) network within which the application of seven established biodosimetric tools (the dicentric assay, the FISH assay, the micronucleus assay, the PCC assay, the gamma-H2AX assay, electron paramagnetic resonance and optically stimulated luminescence) will be compared and standardized among the participating laboratories. METHODOLOGY: Two intercomparisons were organized where blood samples and smartphone components were irradiated, coded and sent out to participating laboratories for dosimetric analysis...
October 25, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27766931/reneb-intercomparisons-applying-the-conventional-dicentric-chromosome-assay-dca
#19
Ursula Oestreicher, Daniel Samaga, Elizabeth Ainsbury, Ana Catarina Antunes, Ans Baeyens, Leonardo Barrios, Christina Beinke, Philip Beukes, William F Blakely, Alexandra Cucu, Andrea De Amicis, Julie Depuydt, Stefania De Sanctis, Marina Di Giorgio, Katalin Dobos, Inmaculada Dominguez, Pham Ngoc Duy, Marco E Espinoza, Farrah N Flegal, Markus Figel, Omar Garcia, Octávia Monteiro Gil, Eric Gregoire, C Guerrero-Carbajal, İnci Güçlü, Valeria Hadjidekova, Prakash Hande, Ulrike Kulka, Jennifer Lemon, Carita Lindholm, Florigio Lista, Katalin Lumniczky, Wilner Martinez-Lopez, Nataliya Maznyk, Roberta Meschini, Radia M'kacher, Alegria Montoro, Jayne Moquet, Mercedes Moreno, Mihaela Noditi, Jelena Pajic, Analía Radl, Michelle Ricoul, Horst Romm, Laurence Roy, Laure Sabatier, Natividad Sebastià, Jacobus Slabbert, Sylwester Sommer, Monica Stuck Oliveira, Uma Subramanian, Yumiko Suto, Tran Que, Antonella Testa, Georgia Terzoudi, Anne Vral, Ruth Wilkins, LusiYanti Yanti, Demetre Zafiropoulos, Andrzej Wojcik
PURPOSE: Two quality controlled inter-laboratory exercises were organized within the EU project 'Realizing the European Network of Biodosimetry (RENEB)' to further optimize the dicentric chromosome assay (DCA) and to identify needs for training and harmonization activities within the RENEB network. MATERIALS AND METHODS: The general study design included blood shipment, sample processing, analysis of chromosome aberrations and radiation dose assessment. After manual scoring of dicentric chromosomes in different cell numbers dose estimations and corresponding 95% confidence intervals were submitted by the participants...
October 21, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27653672/low-dose-radiation-differentially-regulates-protein-acetylation-and-histone-deacetylase-expression-in-human-coronary-artery-endothelial-cells
#20
Zarko Barjaktarovic, Juliane Merl-Pham, Omid Azimzadeh, Stefan J Kempf, Ken Raj, Michael J Atkinson, Soile Tapio
PURPOSE: Ionizing radiation induces cardiovascular disease, the endothelium being the main target. The exact mechanism of the damage is unclear but the involvement of multiple signaling pathways is probable. Reversible lysine acetylation is a posttranslational protein modification that regulates activity across a broad range of signaling pathways. The aim of this study was to determine if a low radiation dose results in acetylome alteration in endothelial cells. MATERIALS AND METHODS: Human coronary artery endothelial cell line was irradiated with Cs-137 gamma-rays (0...
October 21, 2016: International Journal of Radiation Biology
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