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International Journal of Radiation Biology

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https://www.readbyqxmd.com/read/28306402/the-effect-of-radiation-dose-on-the-onset-and-progression-of-radiation-induced-brain-necrosis-in-the-rat-model
#1
Brad A Hartl, Htet S W Ma, Katherine S Hansen, Julian Perks, Michael S Kent, Ruben C Fragoso, Laura Marcu
PURPOSE: To provide a comprehensive understanding of how the selection of radiation dose affects the temporal and spatial progression of radiation-induced necrosis in the rat model. MATERIALS AND METHODS: Necrosis was induced with a single fraction of radiation exposure, at doses ranging between 20 and 60 Gy, to the right hemisphere of 8-week-old Fischer rats from a linear accelerator. The development and progression of necrosis in the rats was monitored and quantified every other week with T1- and T2-weighted gadolinium contrast-enhanced MRI studies...
March 17, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28299960/molecular-dissection-of-the-response-of-the-rice-systemic-acquired-resistance-deficient-1-sard1-gene-to-different-types-of-ionizing-radiation
#2
In Jung Jung, Jung Eun Hwang, Sung Min Han, Dong Sub Kim, Joon-Woo Ahn, Hong-Il Choi, Soon-Jae Kwon, Si-Yong Kang, Jin-Baek Kim
PURPOSE: Exposure to ionizing radiation induces plant defenses by regulating the expression of response genes. The systemic acquired resistance deficient 1 (SARD1) is a key gene in plant defense response. In this study, the function of Oryza sativa SARD1 (OsSARD1) was investigated after exposure of seeds/plants to ionizing radiation, jasmonic acid (JA) or salicylic acid (SA). MATERIALS AND METHODS: Rice seeds exposed to two types of ionizing radiations (gamma ray [GR] and ion beam [IB]) were analyzed by quantitative reverse transcription PCR (qRT-PCR) to identify the genes that are altered in response to ionizing radiation...
March 16, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28291374/mln4924-and-2dg-combined-treatment-enhances-the-efficiency-of-radiotherapy-in-breast-cancer-cells
#3
Maryam Oladghaffari, Ali Shabestani Monfared, Alireza Farajollahi, Behzad Baradaran, Mohsen Mohammadi, Dariush Shanehbandi, Mohammad Asghari Jafar Abadi, Jalil Pirayesh Islamian
PURPOSE: Two-deoxy-D-glucose (2DG) causes cytotoxicity in the cancer cells by disrupting the thiol metabolism, and MLN4924 inactivates the SCF E3 ligase and so causes the accumulation of its substrates which trigger apoptosis and hence might enhance the efficiency of radiotherapy and overcame on the radioresistance of the cancer cells. MATERIALS AND METHODS: SKBR3 and MCF-7 breast cancer cells were treated with 500 μM 2DG and/or MLN4924 (30, 100, 200 and 300 nM), and in combination in the presence and absence of 1, 1...
March 14, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28290238/ra-226-bioaccumulation-and-growth-indices-in-fish
#4
Xiaopei Shi, Richard Smith, Colin Seymour, Carmel Mothersill
PURPOSE: To determine the accumulated activity of Ra-226 in fathead minnows fed with environmentally relevant levels of Ra-226 for 5 months in water at 20 °C, and to evaluate the influence of this level of Ra-226 on the growth of fathead minnows. METHODS: Fathead minnows were fed with fish food containing 10-10,000 mBq/g Ra-226 for 5 months. At the end of the experiment, the fish were sacrificed, flash frozen in liquid nitrogen and kept at -20 °C. Longitudinal sections of 40 μm thickness were cut at the middle of the fish body using a cryostat...
March 14, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28287037/uva-radiation-augments-cytotoxic-activity-of-psoralens-in-melanoma-cells
#5
Dorota Wrześniok, Artur Beberok, Jakub Rok, Marcin Delijewski, Anna Hechmann, Martyna Oprzondek, Zuzanna Rzepka, Barbara Bacler-Żbikowska, Ewa Buszman
PURPOSE: Melanoma is an aggressive form of skin cancer. The aim of the study was to evaluate the influence of UVA radiation and psoralens: 5-methoxypsoralen (5-MOP) or 8-methoxypsoralen (8-MOP) on melanoma cells viability. MATERIALS AND METHODS: The amelanotic C32 and melanotic COLO829 human melanoma cell lines were exposed to increasing concentrations of psoralens (0.1-100 μM) in the presence or absence of UVA radiation. Cell viability was evaluated by the WST-1 assay...
March 13, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28287035/biological-basis-of-radiation-protection-needs-rejuvenation
#6
Tatjana Paunesku, Benjamin Haley, Antone Brooks, Gayle E Woloschak
PURPOSE: Human beings encounter radiation in many different situations - from proximity to radioactive waste sites to participation in medical procedures using X-rays etc. Limits for radiation exposures are legally regulated; however, current radiation protection policy does not explicitly acknowledge that biological, cellular and molecular effects of low doses and low dose rates of radiation differ from effects induced by medium and high dose radiation exposures. Recent technical developments in biology and medicine, from single cell techniques to big data computational research, have enabled new approaches for study of biology of low doses of radiation...
March 13, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28287017/oxidative-stress-and-gsts-genetic-polymorphisms-in-medical-staff-professionally-exposed-to-ionizing-radiation
#7
Hajer Doukali, Ghada Ben Salah, Latifa Hamdaoui, Mounira Hajjaji, Mouna Tabebi, Leila Ammar-Keskes, Mohamed-Elarbi Masmoudi, Hassen Kamoun
PURPOSE: Ionizing radiation (IR) is considered as a diagnostic and therapeutic tool in medicine. However, chronic occupational exposure of medical staff to IR may affect the antioxidant status and, as result, DNA damage and cancers as well. The objective of our study was to evaluate the oxidative stress profile caused by IR in 29 Tunisian medical staff from radiology and radiotherapy departments, and to find an association between the GSTM1null, GSTT1null, and GSTP1 Ile105Val polymorphisms and oxidative stress biomarkers...
March 13, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28281400/evaluation-of-thiol-disulphide-homeostasis-in-radiation-workers
#8
Ural Koc, Sinan Tan, Ahmet Goktug Ertem, Mehmet Gumus, Betul Ozbek, Ozcan Erel
PURPOSE: To evaluate a novel, easily calculated, readily available, and relatively cheap oxidative stress marker, thiol-disulphide homeostasis, in radiation workers and compare the results with healthy controls. MATERIALS AND METHODS: A total of 108 participants were enrolled in the study. The study population included 63 hospital workers occupationally exposed to ionizing radiation in the units of interventional radiology, interventional cardiology and nuclear medicine...
March 10, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28281393/altered-expression-of-a-metformin-mediated-radiation-response-in-sa-nh-and-fsa-tumor-cells-treated-under-in-vitro-and-in-vivo-growth-conditions
#9
Jeffrey S Murley, Richard C Miller, Raziye Rana Senlik, Alfred W Rademaker, David J Grdina
PURPOSE: To assess the radio-sensitizing effect of the biguanide drug Metformin used alone or in combination with reactive oxygen species (ROS) modifying agents N-acetyl-L-cysteine (NAC) or emodin, and contrasted to the mitochondrial complex 1 inhibitor rotenone in altering the radiation responses of the p53 wild type SA-NH and p53 mutant FSa mouse tumor lines grown either in vitro or in vivo. MATERIALS AND METHODS: Tumor cells were grown to confluence in vitro and exposed to a single 4 Gy dose in the presence or absence of Metformin (5 mM) and ROS modifiers or to 10 Gy with or without Metformin as tumors in the flanks of C3H mice using a tumor growth delay assay...
March 10, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28281358/synchrotron-microtomography-to-evaluate-effects-of-different-polychemotherapy-drugs-to-cortical-bone-structure
#10
L P Nogueira, R Alessio, A Mantuano, G Sena, C E de Almeida, G Tromba, A P Almeida, C Salata, M V G Colaço, D Braz, R C Barroso
PURPOSE: In the present work, femur diaphysis of rats, treated with two different chemotherapy drugs, AC (doxorubicin + cyclophosphamide) and TC (docetaxel + cyclophosphamide) were evaluated by 3D morphological analysis using synchrotron radiation microtomography. MATERIALS AND METHODS: Wistar rats were classified into three groups. One group received doses of docetaxel and cyclophosphamide (G1) - TC regimen; another group received doses of doxorubicin and cyclophosphamide (G2) - AC regimen; while control group (G0) received no further treatment...
March 10, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28281355/systemic-effects-of-ionizing-radiation-at-the-proteome-and-metabolome-levels-in-the-blood-of-cancer-patients-treated-with-radiotherapy-the-influence-of-inflammation-and-radiation-toxicity
#11
Karol Jelonek, Monika Pietrowska, Piotr Widlak
Purpose Blood is the most common replacement tissue used to study systemic responses of organisms to different types of pathological conditions and environmental insults. Local irradiation during cancer radiotherapy induces whole body responses that can be observed at the blood proteome and metabolome levels. Hence, comparative blood proteomics and metabolomics are emerging approaches used in the discovery of radiation biomarkers. These techniques enable the simultaneous measurement of hundreds of molecules and the identification of sets of components that can discriminate different physiological states of the human body...
March 10, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28264626/quantitative-changes-in-the-protein-and-mirna-cargo-of-plasma-exosome-like-vesicles-after-exposure-to-ionizing-radiation
#12
Ramesh Yentrapalli, Juliane Merl-Pham, Omid Azimzadeh, Lisa Mutschelknaus, Carsten Peters, Stefanie M Hauck, Michael J Atkinson, Soile Tapio, Simone Moertl
PURPOSE: Multiple cell types secrete exosome-like extracellular vesicles (ELVs) to the extracellular environment. Pathological conditions can produce characteristic changes to the vesicle cargo. We investigated if ionizing radiation is capable of inducing changes in the protein and microRNA (miRNA) cargo of ELVs. MATERIALS AND METHODS: Whole blood samples from healthy donors were irradiated with 2 Gy gamma rays and then peripheral blood mononuclear cells and plasma were separated from residual blood and co-cultivated for 24 h...
March 7, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28264623/cellular-detection-of-50%C3%A2-hz-magnetic-fields-and-weak-blue-light-effects-on-superoxide-levels-and-genotoxicity
#13
Anne Höytö, Mikko Herrala, Jukka Luukkonen, Jukka Juutilainen, Jonne Naarala
PURPOSE: We tested the hypothesis that the effects of 50 Hz magnetic fields (MFs) on superoxide levels and genotoxicity depend on the presence of blue light. MATERIALS AND METHODS: Human SH-SY5Y neuroblastoma cells were exposed to a 50 Hz, 100 μT MF with or without non-phototoxic level of blue light for 24 h. We also studied whether these treatments alter responses to menadione, an agent that induces mitochondrial superoxide (O2(• -)) production and DNA damage...
March 7, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28276897/computational-modeling-of-radiobiological-effects-in-bone-metastases-for-different-radionuclides
#14
Francisco D C Guerra Liberal, Adriana Alexandre S Tavares, João Manuel R S Tavares
PURPOSE: Computational simulation is a simple and practical way to study and to compare a variety of radioisotopes for different medical applications, including the palliative treatment of bone metastases. This study aimed to evaluate and compare cellular effects modelled for different radioisotopes currently in use or under research for treatment of bone metastases using computational methods. METHODS: Computational models were used to estimate the radiation-induced cellular effects (Virtual Cell Radiobiology algorithm) post-irradiation with selected particles emitted by Strontium-89 ((89)Sr), Samarium-153 ((153)Sm), Lutetium-177 ((177)Lu), and Radium-223 ((223)Ra)...
March 3, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28276896/skin-absorption-of-actinides-influence-of-solvents-or-chelates-on-skin-penetration-ex-vivo
#15
Anissa Tazrart, Marie-Alexandrine Bolzinger, Sylvie Coudert, Stephanie Lamart, Brian W Miller, Jaime F Angulo, Stéphanie Briançon, Nina M Griffiths
PURPOSE: To evaluate skin penetration and retention of americium (Am) and plutonium (Pu), in different chemical forms relevant to the nuclear industry and to treatment by chelation. MATERIALS AND METHODS: Percutaneous penetration of different Am and Pu forms were evaluated using viable pig skin with the Franz cell diffusion system. The behavior of the complex Pu-tributyl phosphate (Pu-TBP), Am or Pu complexed to the chelator Diethylene triamine pentaacetic acid (DTPA) and the effect of dimethyl sulfoxide (DMSO) was assessed...
March 3, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28276898/association-of-ribosomal-protein-s6-kinase-1-with-cellular-radiosensitivity-of-non-small-lung-cancer
#16
Ye Wang, Hong Mei, Qiang Shao, Jian Wang, Zhenyu Lin
PURPOSE: Ribosomal S6 kinase 1 (S6K1) plays an important role in cell proliferation, protein translation and cell survival. This study investigated the possibility of using S6K1 as a new target in the radiotherapy of non-small cell lung cancer (NSCLC) and its potential mechanism. MATERIALS AND METHODS: shRNA interference technology was applied to silence the expression of S6K1 in A549 and H460, and clonogenic assay was performed to measure the radiosensitizing effects...
March 2, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28134023/effects-of-ionizing-radiation-on-dna-methylation-from-experimental-biology-to-clinical-applications
#17
Isabelle R Miousse, Kristy R Kutanzi, Igor Koturbash
PURPOSE: Ionizing radiation (IR) is a ubiquitous environmental stressor with genotoxic and epigenotoxic capabilities. Terrestrial IR, predominantly a low-linear energy transfer (LET) radiation, is being widely utilized in medicine, as well as in multiple industrial applications. Additionally, an interest in understanding the effects of high-LET irradiation is emerging due to the potential of exposure during space missions and the growing utilization of high-LET radiation in medicine. CONCLUSIONS: In this review, we summarize the current knowledge of the effects of IR on DNA methylation, a key epigenetic mechanism regulating the expression of genetic information...
February 21, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28276899/multidisciplinary-european-low-dose-initiative-an-update-of-the-melodi-program
#18
Sisko Salomaa, Jean-René Jourdain, Michaela Kreuzer, Thomas Jung, Jacques Repussard
PURPOSE: This paper provides an update and summary on the organization of European research in the field of low dose risk and radiation protection. To address declining resources and competence in radiation protection and related research across European countries, a High Level and Expert Group (HLEG) was established in 2007. The HLEG identified key policy and scientific questions to be addressed through a strategic research agenda for low dose radiation risk. This initiated the establishment of a European Research Platform, called MELODI (Multidisciplinary European Low Dose Research Initiative)...
February 8, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28151050/can-radiation-research-impact-the-estimation-of-risk
#19
R Julian Preston
PURPOSE: This review is a contribution to the memory of Dr William (Bill) Morgan and highlights an area of research and deliberation that he considered extremely important in support of the setting of protective radiation dose limits. Biological research has generally played a minor role in the estimation of adverse health outcomes following exposure to low doses and low dose rates of radiation. The reliance has been on the available, quite extensive data base of epidemiology studies...
February 2, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28151038/cardiovascular-disease-among-atomic-bomb-survivors
#20
Kotaro Ozasa, Ikuno Takahashi, Eric J Grant, Kazunori Kodama
PURPOSE: The profile of cardiovascular disease in Japan has been different from that in Western countries. Hypertension was the major cause not only for hemorrhagic stroke but also for ischemic stroke and heart disease in the past, and the influence of hypertension has decreased with calendar years because of reduced salt intake and westernization of lifestyle, and also improved medical care. The health status of atomic bomb survivors has reflected this profile as well as radiation effects...
February 2, 2017: International Journal of Radiation Biology
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