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International Journal of Radiation Biology

Tyler A Beach, Angela M Groves, Carl J Johnston, Jacqueline P Williams, Jacob N Finkelstein
PURPOSE: Radiation-induced lung injuries (RILI), namely radiation pneumonitis and/or fibrosis, are dose-limiting outcomes following treatment for thoracic cancers. As part of a search for mitigation targets, we sought to determine if persistent DNA damage is a characteristic of this progressive injury. METHODS: C57BL/6J female mice were sacrificed at 24 h, 1, 4, 12, 16, 24 and 32 weeks following a single dose of 12.5 Gy thorax only gamma radiation; their lungs were compared to age-matched unirradiated animals...
September 21, 2018: International Journal of Radiation Biology
Marko Dinčić, Danijela Z Krstić, Mirjana B Čolović, Jelena Nešović Ostojić, Sanjin Kovačević, Silvio R De Luka, Drago M Djordjević, Saša Ćirković, Predrag Brkić, Jasna Todorović
PURPOSE: It is considered that exposure to static magnetic fields (SMF) may have both detrimental and therapeutic effect, but the mechanism of SMF influence on the living organisms is not well understood. Since the adenosine triphosphatases (ATPases) and acetylcholinesterase (AChE) are involved in both physiological and pathological processes, the modulation of Na+ /K+ -ATPase, ecto-ATPases and AChE activities, as well as oxidative stress responses were followed in synaptosomes isolated from rats after chronic exposure toward differently oriented SMF...
September 21, 2018: International Journal of Radiation Biology
F T J Santos, W N Siqueira, M L O Santos, H A M F Silva, J L F Sá, T S Fernandes, N H Silva, E J França, E B Silva, A M M A Melo
PURPOSE: Some phytochemicals have shown the potential of being radiomodifiers, especially phenolic compounds, such as lichenic secondary metabolites. To evaluate the phytochemical usnic acid as a radiomodifier, embryonic cells of molluscs have been used due to their ease of collection, high sensitivity to physical and chemical agents, well-known embryology and low cost for analysis. MATERIALS AND METHODS: This study aimed to assess the radiosensitizing action of usnic acid on Biomphalaria glabrata embryos...
September 18, 2018: International Journal of Radiation Biology
Hamid Abdollahi, Seied Rabi Mahdavi, Bahram Mofid, Mohsen Bakhshandeh, Abolfazl Razzaghdoust, Afshin Saadipoor, Kiarash Tanha
PURPOSE: To investigate MRI radiomic analysis to assess IMRT associated rectal wall changes and also for predicting radiotherapy induced rectal toxicity. MATERIAL AND METHODS: At first, a machine learning radiomic analysis was applied on T2-weighted (T2W) and apparent diffusion coefficient (ADC) rectal wall MR images of prostate cancer patients' pre- and post-IMRT to predict rectal toxicity. Next, Wilcoxon singed ranked test was performed to find radiomic features with significant changes pre- and post-IMRT...
September 10, 2018: International Journal of Radiation Biology
Parisa Rezaie, Samideh Khoei, Sepideh Khoee, Sakine Shirvalilou, Seied Rabi Mahdavi
PURPOSE: Glioblastoma multiform (GBM) is the most prevalent and aggressive type of primary brain tumor. None of the current conventional treatment methods has improved treatment considerably. Therefore, in this study the effect of magnetic nanoparticles coated with poly (caprolactone)-poly (ethylene glycol) (PCL-PEG) as a 5-iodo 2'deoxyuridine (IUdR) carrier in the presence of hyperthermia and 6 MV (megavoltage) X-ray radiation, were investigated in a spheroid model of U87MG glioblastoma cell line using colony formation assay...
August 21, 2018: International Journal of Radiation Biology
Ilya O Velegzhaninov, Anastasia V Ermakova, Dmitry Yu Klokov
PURPOSE: Exposure to high dose ionizing radiation leads to premature cell senescence and suppression of cell proliferation. In contrast, low dose and low dose-rate gamma-irradiation can lead to stimulation of cell proliferation. We aimed to examine whether the low dose radiation-induced proliferation of normal human fibroblasts can lead to a progressive depletion of proliferation potential and to an early onset of senescence. MATERIALS AND METHODS: Normal human embryonic lung fibroblasts (HELF-104) at passage 22-24 were gamma-irradiated with doses of 0 (sham-irradiation), 10, 30, 50, 90, 120, 150, 200, and 500 mGy as well as 1 and 2 Gy...
August 21, 2018: International Journal of Radiation Biology
Enis Hidisoglu, Deniz Kantar-Gok, Sukru Ozen, Piraye Yargicoglu
PURPOSE: There is a growing interest in the usage of radiofrequency radiation (RF) as a noninvasive brain stimulation method. Previously reported data demonstrated that RF exposure caused a change in brain oscillations. Therefore, we aimed to investigate effects of RF on brain oscillation by measuring the auditory response of different brain regions in rats. MATERIALS AND METHODS: Rats were randomly divided into three groups (n = 12 per each group): Cage control (C), sham rats (Sh), and rats exposed to 2...
August 21, 2018: International Journal of Radiation Biology
Roland Wunderlich, Paul Friedrich Rühle, Lisa Deloch, Franz Rödel, Rainer Fietkau, Udo S Gaipl, Benjamin Frey
PURPOSE: Previous investigations revealed influences of irradiation up to 2Gy on the cytokine secretion profile of inflammatory and peritoneal mouse macrophages (pMФ). This raised the question if those alterations impact on dendritic cells and consecutive T-cell responses. Further, the impact of irradiation directly on pMФ capacity to induce T-cell responses was analyzed. MATERIALS AND METHODS: pMФ were LPS-activated, irradiated and the expression of activation markers was assessed...
August 21, 2018: International Journal of Radiation Biology
Stéphane Grison, Ghada Elmhiri, Céline Gloaguen, Christelle Elie, Dimitri Kereselidze, Karine Tack, Philippe Lestaevel, Audrey Legendre, Line Manens, Mohamed Amine Benadjaoud, Jean-Marc Lobaccaro, Maâmar Souidi
PURPOSE: A protocol of chronic exposure to low dose of uranium was established in order to distinguish the sexual differences and the developmental process that are critical windows for epigenetic effects over generations. METHODS: Both male and female rats were contaminated through their drinking water with a non-toxic solution of uranyl nitrate for 9 months. The exposed generation (F0) and the following two generations (F1 and F2) were examined. Clinical monitoring, global DNA methylation profile and DNA methyltransferases (DNMTs) gene expression were analyzed in kidneys...
August 15, 2018: International Journal of Radiation Biology
Mohamed A El-Missiry, Azza I Othman, Mamdouh R El-Sawy, Mohamad F Lebede
PURPOSE: This study investigated the potential neuroprotective effect of epigallocatechin-3-gallate (EGCG) on radiation-induced cell death and damage in the hippocampus. MATERIALS AND METHODS: Adult male Wister rats received oral treatment with EGCG at doses of 2.5 and 5 mg/kg/d for 3 d before 4 Gy γ irradiation. RESULTS: The pretreatment of irradiated rats with EGCG significantly ameliorated the increased plasma levels of homocysteine, amyloid β, TNF-α and IL-6 levels and the decrease of dopamine and serotonin...
August 15, 2018: International Journal of Radiation Biology
Nadia Abdel-Magied, Amal G Ahmed, Nahed Abo Zid
PURPOSE: To evaluate the radioprotective efficacy of date (Phoenix dactylifera) pits extract (DPE) against γ-irradiation-induced liver damage in the male albino rats. For this study, 30-day survival, dose reduction factor (DRF), antioxidant status and some biochemical changes in the serum and hepatic tissue were evaluated. MATERIALS AND METHODS: To calculate 30-day survival, median lethal dose of 30 days (LD50/30) and DRF, DPE was orally administered to rats for 21 days before irradiation with different doses (5, 6, 8, 10 and 12 Gy) of γ-rays and the rats were observed for 30 days post-irradiation...
August 10, 2018: International Journal of Radiation Biology
Nitin Motilal Gandhi
PURPOSE: Cellular damage due to low dose of γ-radiation (≤0.1 Gy) is generally extrapolated from observing the effects at higher doses. These estimations are not accurate. This has led to uncertainties while assessing the radiation risk factors at low doses. Although there are reports on the radiation induced adaptive response, the mechanism of action is not fully elucidated, leading to the uncertainties. One of the outcomes of low dose radiation exposure is believed to be an adaptive response...
August 10, 2018: International Journal of Radiation Biology
Ali Masoumi, Narges Karbalaei, S M J Mortazavi, Mohammad Shabani
PURPOSE: There is a great concern regarding the possible adverse effects of electromagnetic radiation (EMR). This study investigated the effects of EMR induced by Wi-Fi (2.45 GHz) on insulin secretion and antioxidant redox systems in the rat pancreas. MATERIALS AND METHODS: Adult male Sprague-Dawley rats in the weight range of 230-260 g were divided into control, sham, Wi-Fi exposed groups. After long-term exposure (4 h/day for 45 days) to Wi-Fi EMR, plasma levels of glucose and insulin during intraperitoneal glucose tolerance test were measured...
August 10, 2018: International Journal of Radiation Biology
Ahmed I Hasaballah
PURPOSE: The aim was to evaluate the effects of irradiation of Culex pipiens irradiated as pupae on the larval and pupal mortality percentages, the larval and pupal duration, adult emergence percentages and ovarian development in comparison with the un-irradiated group. MATERIAL AND METHODS: The mosquito, C. pipiens Linnaeus (L) was irradiated as pupae with three gamma doses 40, 60 and 80 Gy. Different biological aspects include the ovarian development of irradiated females tested...
July 29, 2018: International Journal of Radiation Biology
Seong Hee Kang, Seong Pyo Hong, Bo Sun Kang
PURPOSE: This report presents novel nanoparticle-based drug delivery system (NPDDS) aiming to targeting chemo-proton therapy (TCPT) to improve the therapeutic efficacy on brain cancer treatments. MATERIALS AND METHODS: A NPDDS, superparamagnetic iron oxide nanoparticles conjugated with folate and paclitaxel, was synthesized and applied to C6 brain cancer cell line that was prepared for targeting chemo-proton therapy. The characterization of NPDDS was analyzed by transmission electron microscope (TEM) and Fourier transform infrared (FTIR) spectroscopy...
July 23, 2018: International Journal of Radiation Biology
Brahim Selmaoui, Soafara Andrianome, Rania Ghosn, René de Seze
PURPOSE: The present study aimed to determine the effect of acute exposure to electromagnetic fields (EMF) emitted by a mobile phone on electrodermal activity (EDA) in response to an auditory stimulus. MATERIALS AND METHODS: The EDA of 28 young volunteers was recorded following 26 min of exposure to a GSM mobile phone (900 MHz). Palmar sensors enabled repeat recording of 2 min 45 s in the pre-exposure, exposure and post-exposure phases in response to sound stimuli...
July 20, 2018: International Journal of Radiation Biology
Birşen Bilgici, Seda Gun, Bahattin Avci, Ayşegül Akar, Begüm K Engiz
PURPOSE: To investigate the inflammatory effect and testicular damage on rats exposed to low level of electromagnetic fields (EMF) at 2.45 GHz microwave radiation. METHODS: Twenty two Wistar rats were divided into two groups. Group 1 was the control group and not exposed to EMF. Group 2 was exposed to low level EMF (average E-field 3.68± 0.36 V/m, whole body average SAR, 0.0233W/kg, in 10g tissue) at 2.45 GHz for 1 hour/day for 30 consecutive days. At the end of the study, interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-32 (IL-32), C-reactive protein (CRP) were measured in rat serum and IL-6, IL-10, IL-32 were measured in rat testis tissue...
July 20, 2018: International Journal of Radiation Biology
Joanna Wyszkowska, Tomasz Jędrzejewski, Jakub Piotrowski, Anna Wojciechowska, Maria Stankiewicz, Wieslaw Kozak
PURPOSE: Epidemiological data suggest that there is a link between exposure to extremely low-frequency magnetic fields (ELF-MFs), immune response and the occurrence of neurodegenerative diseases. The exact nature of this phenomenon remains speculative and requires detailed laboratory investigation. In the present study we evaluate changes in plasma concentration of pro-inflammatory and regulatory cytokines as well as alternations of the haematological parameters in rats exposed to an ELF-MF...
July 20, 2018: International Journal of Radiation Biology
Ursula Oestreicher, David Endesfelder, Maria Gomolka, Ausra Kesminiene, Peter Lang, Carita Lindholm, Ute Rößler, Daniel Samaga, Ulrike Kulka
PURPOSE: Automated detection of dicentric chromosomes from a large number of cells was applied to study age-dependent radiosensitivity after in vitro CT exposure of blood from healthy donors Materials and Methods: Blood samples from newborns, children (2-5 y.) and adults (20 - 50 y.) were exposed in vitro to 0 mGy, 41 mGy and 978 mGy using a CT equipment. In this study automated scoring based on 13,000-31,000 cells/dose point/age group was performed. Results for control and low dose points were validated by manually counting about 26,000 cells/dose point/age group Results: For all age groups, the high number of analyzed cells enabled the detection of a significant increase in the frequency of radiation induced dicentric chromosomes in cells exposed to 41 mGy as compared to control cells...
July 20, 2018: International Journal of Radiation Biology
Abdulhamid Chaikh, Valentin Calugaru, Pierre-Yves Bondiau, Juliette Thariat, Jacques Balosso
PURPOSE: The aim of this study is to evaluate the impact of normal tissue complication probability (NTCP)-based radiobiological models on the estimated risk for late radiation lung damages. The second goal is to propose a medical decision-making approach to select the eligible patient for particle therapy. MATERIALS AND METHODS: Fourteen pediatric patients undergoing cranio-spinal irradiation were evaluated. For each patient, two treatment plans were generated using photon and proton therapy with the same dose prescriptions...
July 16, 2018: International Journal of Radiation Biology
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