journal
https://read.qxmd.com/read/38010136/emerging-trends-and-research-priorities-in-premature-ovarian-insufficiency-genes-a-bibliometric-and-visualization-study
#21
REVIEW
Xi Zhao, Wenying Shi, Xiaojuan Liu, Wei Zhang
PURPOSE: To illustrate the results achieved by genes in premature ovarian insufficiency (POI) and collaborations in the field, and to explore key themes and future directions. METHODS: Articles and reviews related to POI genes published between 1990 and 2022 were retrieved from the Web of Science core collection (WoSCC) for the total bibliometric analysis. Tools were analyzed for publication, country, institution, journal, authors, reference, keywords, subject categories, funding agencies, and research hotspots using a bibliometric online analysis platform, Bibliographic Co-occurrence Matrix Builder (BICOMB), CiteSpace V, and VOSviewer...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37967572/expression-of-high-mobility-group-box-1-in-eutopic-ectopic-endometrium-and-correlations-with-inflammation-related-factors-in-adenomyosis
#22
JOURNAL ARTICLE
Xiu-Ni Liu, Zhong-Ping Cheng
OBJECTIVE: To investigate the expression of HMGB1 and toll-like receptor 4 (TLR4) in adenomyosis eutopic/ectopic endometrium. METHODS: Twenty patients with adenomyosis and 20 controls, all undergoing laparoscopy, were recruited from September 2015 to July 2016. Samples were collected from the endometrium without adenomyosis (CE), the eutopic endometrium with adenomyosis (EuE), and the ectopic endometrium with adenomyosis (EE). The mRNA and protein expression of HMGB1 and TLR4, and interleukin-6 (IL-6) and interleukin-8 (IL-8) RNA expression levels were measured...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37935245/association-between-leptin-receptor-polymorphisms-and-polycystic-ovary-syndrome-risk-a-meta-analysis-based-on-11-studies
#23
JOURNAL ARTICLE
Na-Na Wang, Min Tang, Han-Yu Zhang, Qiao-Zhen Yang, Gong-Li Yang
OBJECTIVE: Published evidence indicated that the leptin receptor (LEPR) gene polymorphisms are associated with polycystic ovary syndrome (PCOS) risk. However, studies on the association between the polymorphisms of LEPR gene are inconsistent or even controversial. MATERIAL AND METHODS: We conducted this meta-analysis to explore the more precise relationship between LEPR polymorphisms and PCOS risk. Relevant articles were searched with five online databases up to March 1 2023...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37913814/is-elevated-baseline-shbg-associated-with-increased-ovulation
#24
JOURNAL ARTICLE
Hui Chang, Hang Ge, Qi Wu, Jian Li, Yanli Zhang, Mengyi Zhu, Xi Luo, Yanhua Han, Yong Wang, Chi Chiu Wang, Xiaoke Wu
Sexual hormone binding globulin (SHBG) is associated with the endocrine and reproductive systems. We aimed to investigate the role of SHBG in the reproductive process. Therefore, we conducted a secondary analysis of the PCOSAct (Polycystic Ovary Syndrome and Acupuncture Clinical Trial) study, which involved 21 sites in China and a total of 1000 women with PCOS. Out of these, 954 women with SHBG were included in the analysis. Through multivariate analysis of ovulation predictors, we found that age, BMI, estradiol, testosterone, and SHBG all showed a positive predictive value for ovulation ( p  = 0...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37913790/anti-m%C3%A3-llerian-hormone-promotes-human-osteoblast-differentiation-and-calcification-by-modulating-osteogenic-gene-expression
#25
JOURNAL ARTICLE
Francesca Liuzzi, Marilena Taggi, Serena De Carlini, Antonio La Marca
OBJECTIVE: To investigate whether the Anti-Müllerian Hormone (AMH), an ovarian hormone belonging to the Transforming Growth Factor β superfamily, may represent a possible candidate for use as a bone anabolic factor. METHODS: We performed in vitro studies on Human Osteoblasts (HOb) to evaluate the expression and the functionality of AMHRII, the AMH receptor type-2, and investigate the effects of exogenous AMH exposure on osteogenic gene expression and osteoblast functions...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37884010/vasorin-a-new-molecule-in-human-reproduction
#26
EDITORIAL
Antonio La Marca, Serena De Carlini, Francesca Liuzzi
No abstract text is available yet for this article.
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37871609/down-regulation-of-the-fto-gene-in-follicular-fluid-of-infertile-women-with-ovarian-endometriosis
#27
JOURNAL ARTICLE
Yanmei Li, Naihui Wang, Yuanxue Jing, Jiajing He, Fangfang Li, Xuehong Zhang
OBJECTIVE: To evaluate FTO concentrations in follicular fluid (FF) of women with ovarian endometriosis (OE) and controls women without OE undergoing in vitro fertilization-embryo transfer (IVF-ET). METHODS: FTO concentrations in FF were measured in 74 patients (37 in the control group and 37 in the OE group) by ELISA. We measured the expression of FTO in GCs of 40 patients (19 in the control group and 21 in the OE group) by RT-qPCR. The level of m6 A in GCs was measured in 20 patients (10 in the control group and 10 in the OE group) by colorimetry...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37859610/the-effects-of-different-endometrial-preparation-regimens-on-pregnancy-outcomes-in-frozen-thawed-embryo-transfer-cycles-a-prospective-randomized-controlled-study
#28
RANDOMIZED CONTROLLED TRIAL
Jianyun Huang, Xuedan Jiao, Yang You, Yingchen Wu, Haiyan Lin, Qingxue Zhang
OBJECTIVE: An increasing number of research have emerged to compare the pregnancy outcomes between the natural cycle and the hormone replacement therapy (HRT) cycle in preparing the endometrium for frozen-thawed embryo transfer (FET), but the results are controversial. This prospective randomized controlled study was hence designed to obtain more solid evidence. MATERIALS AND METHODS: In this study, patients with regular menstrual cycle length (21-35 days) who underwent FET between January 2010 to December 2017 were recruited for this study...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37859604/estrogen-receptor-related-receptor-%C3%AE-uppresses-hypoxia-induced-angiogenesis-by-regulating-vegfa-in-endometrial-cancer
#29
JOURNAL ARTICLE
Xiao-Xiao Wang, Teng Hua, Hong-Bo Wang
OBJECTIVE: Estrogen receptor-related receptor γ (ERRγ), is implicated in cancer cell proliferation and metastasis. The function of ERRγ in tumor angiogenesis, however, is to be revealed. This study was designed to elaborate the regulatory effect of ERRγ on angiogenesis in endometrial cancer (EC). METHODS: Immunohistochemistry (IHC) was adopted to determine the protein expression of ERRγ, VEGFA, CD31 and hypoxia-inducible factor-1 (HIF-1) in tumor tissues...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37857350/combined-oral-contraceptives-update-recommendations-of-the-latin-american-contraceptive-association
#30
REVIEW
Santiago Palacios, Gabriela Ayala, Gemarilis González, Can L Badilla-Apuy, Jeannette Marchena, Katia Martínez, Desireé Mostajo, María S Vernaza, Alejandro Paradas, Luis Hernández, David Vásquez-Awad, Cuauhtémoc Celis-González, Nilson Roberto de Melo
Background: In recent years, new combined oral contraceptives (COCs) have become available, representing an advance in terms of individualization and compliance by users. Objective: To provide recommendations regarding COCs: formulations, use, efficacy, benefits and safety. Method: For these recommendations, we have used the modified Delphi methodology and carried out a systematic review of studies found in the literature and reviews performed in humans, published in English and Spanish in Pubmed, Medline and advanced medicine and computer networks until the year 2021, using the combination of terms: 'oral contraceptives', 'estroprogestins' and 'combined oral contraceptives'...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37857342/expression-and-significance-of-silent-information-regulator-two-homolog-1-in-the-placenta-and-plasma-of-patients-with-pre-eclampsia-a-meta-analysis
#31
JOURNAL ARTICLE
Hongling Wang, Wenwen Liang, Weihua Su, Hong Cui, Huifeng Wang
OBJECTIVE: This study aimed to collect, organize, and conduct a meta-analysis of the literature on the expression of silent information regulator two homolog 1 (SIRT1) in the placental tissue and plasma of patients with pre-eclampsia. METHODS: The enrolled patients were divided into two groups: the pre-eclampsia group and the healthy group. This study summarized and analyzed the demographic characteristics of the two groups, including pregnancy age, gestational weeks, parity, gravidity, blood pressure, Body Mass Index, newborn weight, placental weight, and SIRT1 expression in placental tissue and maternal plasma...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37855244/lipus-combined-with-tfsc-alleviates-premature-ovarian-failure-by-promoting-autophagy-and-inhibiting-apoptosis
#32
JOURNAL ARTICLE
Weimei Zhou, Aixue Chen, Yongju Ye, Yuefang Ren, Jiali Lu, Feilan Xuan, Ruiying Jin
OBJECTIVE: Premature ovarian failure (POF), also known as primary ovarian insufficiency, is a major cause of infertility in female worldwide. Excessive apoptosis and impaired autophagy in ovarian granulosa cells are the main pathological mechanisms of POF. The total flavonoids from semen cuscutae (TFSC) are often used in the treatment of gynecological endocrine disorders. In addition, low intensity pulsed ultrasound (LIPUS) is report as an effective method to improve ovarian function...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37849277/effect-of-bushen-huoxue-recipe-on-serum-metabolomics-in-polycystic-ovary-syndrome-rats
#33
JOURNAL ARTICLE
Junjie Li, Hongqiu Zhu, Ying Zhu, Peijuan Wu, Hanxue Wu, Haiyan Chen
OBJECTIVE: To investigate the effect of Bushen Huoxue Recipe (BSHXR) on serum metabolomics in polycystic ovary syndrome rat (PCOSR). METHODS: In our study, twenty-four 6-week-old Sprague-Dawley (SD) female rats were randomly divided into three groups: treatment group, model group and blank group. The blank group and other groups were gavaged in different ways each morning, and the rats were treated with normal saline or BSHXR containing liquid each afternoon. Liquid chromatography-mass spectrometry (LC-MS) was employed to study serum metabolites in the treatment group after the study as well as in the model and blank groups...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37846544/estrogen-promotes-the-proliferation-and-migration-of-endometrial-cancer-cells-by-upregulating-the-expression-of-lncrna-hotair
#34
JOURNAL ARTICLE
Huixiao Wang, Xulan Ma, Ziwen Jiang, Di Xia, Feng Sui, Fengxian Fu, Yinmei Dai
OBJECTIVE: Estrogen (E2) is the main contributor to the progression of endometrial cancer (EC). The long noncoding RNA HOX antisense intergenic RNA (HOTAIR) is emerging as a new regulator in several cancer types. This study aimed to investigate the role of HOTAIR in EC development and identify the underlying molecular mechanisms. METHODS: HOTAIR expression levels in human EC tissues and the corresponding adjacent tissues and human EC Ishikawa cells were determined by quantitative PCR...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37844908/cocktail-treatment-by-gnrh-antagonist-letrozole-and-mifepristone-for-the-prevention-of-ovarian-hyperstimulation-syndrome-a-prospective-randomized-trial
#35
JOURNAL ARTICLE
Qianrong Qi, Yi Xia, Jin Luo, Yaqin Wang, Qingzhen Xie
OBJECTIVE: This study is aimed to determine the efficacy of a cocktail style treatment by combining GnRH-antagonist, letrozole, and mifepristone on the prevention of ovarian hyperstimulation syndrome (OHSS) in high-risk women. METHODS: This prospective, randomized controlled clinical trial was performed between January 2018 and December 2018. A total of 170 women who identified as high risk of OHSS during the ovarian hyperstimulation and underwent cryopreservation of whole embryos...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37811796/vulvovaginal-atrophy-in-the-creta-study-the-healthcare-professionals-perception
#36
JOURNAL ARTICLE
María J Cancelo, Rafael Sánchez Borrego, Santiago Palacios, Laura Baquedano, Tanit Corbacho Garza, Noelia Fernández Aller, Carmen García Ferreiro, Juan José Quijano Martín, A Javier González Calvo
OBJECTIVES: The objective is to assess the perception of gynecologists regarding patients' adherence to vulvovaginal atrophy (VVA) treatments, to evaluate the gynecologists' opinions on what their patients think about treatment adherence, and to compare the gynecologists' opinions with the patients' own perceptions within the CRETA study. METHODS: Spanish gynecologists who participated in the CRETA study were asked to fill out an online 41-item questionnaire to evaluate their views on VVA management...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37798837/tpoab-positivity-can-impact-ovarian-reserve-embryo-quality-and-ivf-icsi-outcomes-in-euthyroid-infertile-women
#37
JOURNAL ARTICLE
Shi-Xi Wei, Ling Wang, Yu-Bing Liu, Qiu-Lin Fan, Yu Fan, Kun Qiao
The aim of this study was to investigate the effects of positive anti-thyroid peroxidase (TPO) antibodies on fertility, embryo quality, and pregnancy outcomes in women with normal thyroid function. A cross-sectional study of 1223 infertile women who received assisted reproductive technology (ART) treatment for the first time was conducted at our hospital from January 2019 to March 2022. Overall, 263 infertile women were included, comprising 263 cycles and 1813 embryos, and were divided into a positive group and a control group based on TPO antibody levels...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37706434/the-ameliorating-effects-of-guizhi-fuling-wan%C3%A2-combined-with-rosiglitazone-in-a-rat-ovarian-model-of-polycystic-ovary-syndrome-by-the-pi3k-akt-nf-%C3%AE%C2%BAb-and-nrf2-ho-1-pathways
#38
JOURNAL ARTICLE
Yongju Ye, Weimei Zhou, Yuefang Ren, Jiali Lu, Aixue Chen, Ruiying Jin, Feilan Xuan
OBJECTIVE: GuizhiFulingWan (GFW) has been reported to be effective against polycystic ovary syndrome (PCOS) by possessing oxidative stress and inflammation which related to PI3K/AKT/NF-κB, Nrf2/HO-1 pathway. This study aims to probe the effects and mechanisms of GFW combined with rosiglitazone on PCOS via PI3K/AKT/NF-κB and Nrf2/HO-1 pathways. METHODS: A rat PCOS model established by dehydroepiandrosterone (DHEA) injection. The experiment was allocated to control, DHEA, GFW, rosiglitazone, GFW + rosiglitazone groups...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37673102/association-between-endometriosis-and-metabolic-syndrome-a-cross-sectional-study-based-on-the-national-health-and-nutrition-examination-survey-data
#39
JOURNAL ARTICLE
Baijia Li, Yuxue Zhang, Liuhang Zhang, Lingyan Zhang
BACKGROUND: Endometriosis has been reported to be associated with metabolism-related diseases, such as hypercholesterolemia and diabetes, while no studies have reported the association between endometriosis and metabolic syndrome. OBJECTIVE: This study aims to explore the association between endometriosis and metabolic syndrome. Also, the association between endometriosis and single metabolic syndrome indicator was explored. METHODS: This was a cross-sectional study based on the National Health and Nutrition Examination Survey (NHANES)...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37673099/prevalence-of-metabolic-syndrome-and-its-components-in-chinese-women-with-premature-ovarian-insufficiency
#40
JOURNAL ARTICLE
Jing Jin, Xiangyan Ruan, Lin Hua, Alfred O Mueck
OBJECTIVES: To assess the prevalence of metabolic syndrome (MetS) and its components in Chinese women with premature ovarian insufficiency (POI) and to explore the metabolic profile of Chinese women with POI. METHODS: 118 POI women aged 20-38 years and 151 age-and-BMI-matched control women were recruited. Measurements included body height, weight, waist circumference (WC), hip circumference (HC), blood pressure, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG) and fasting insulin (FINS)...
December 2023: Gynecological Endocrinology
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