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Gynecological Endocrinology

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https://www.readbyqxmd.com/read/28332865/the-association-between-ultrasound-estimated-visceral-fat-deposition-and-uterine-fibroids-an-observational-study
#1
Andrea Ciavattini, Giovanni Delli Carpini, Lorenzo Moriconi, Nicolò Clemente, Francesca Orici, Anna Chiara Boschi, Nina Montik, Laura Mazzanti
Uterine fibroids are the most common neoplasm of the genital tract in reproductive women. Obesity holds a role as risk factor for uterine fibroids, through hormonal and inflammatory mechanisms. Visceral fat is a hormonally active tissue, so an increase in visceral fat may be considered as a risk factor, through the increased production of inflammatory mediators. The aim of the study was, therefore, to evaluate the association between the presence of uterine fibroids and fat tissue distribution, and to assess the efficacy of both anthropometric and instrumental indicators, in particular the sonographic measurement of preperitoneal fat thickness (PFT) and subcutaneous fat thickness (SFT)...
March 23, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28300476/ovarian-steroid-hormones-modulate-the-expression-of-progesterone-receptors-and-histone-acetylation-patterns-in-uterine-leiomyoma-cells
#2
Gabriela Dos Santos Sant'Anna, Ilma Simoni Brum, Gisele Branchini, Lolita Schneider Pizzolato, Edison Capp, Helena von Eye Corleta
Uterine leiomyomas are the most common benign smooth muscle cell tumors in women. Estrogen (E2), progesterone (P4) and environmental factors play important roles in the development of these tumors. New treatments, such as mifepristone, have been proposed. We evaluated the gene expression of total (PRT) and B (PRB) progesterone receptors, and the histone acetyltransferase (HAT) and deacetylase (HDAC) activity after treatment with E2, P4 and mifepristone (RU486) in primary cell cultures from uterine leiomyoma and normal myometrium...
March 16, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28300467/association-of-cyp1a1-and-cyp1b1-polymorphisms-with-bone-mineral-density-variations-in-postmenopausal-mexican-mestizo-women
#3
Bertha Chávez, Felipe Vilchis, David Rojano-Mejía, Ramón Mauricio Coral Vázquez, María Del Carmen Aguirre-García, Patricia Canto
Herein, we investigated potential associations between polymorphisms of genes related to estrogen metabolism and bone mineral density (BMD) in postmenopausal women. This was a cross-sectional study, in which two hundred and ninety postmenopausal Mexican-Mestizo women were studied. The BMD of the lumbar spine (LS), total hip (TH), and femoral neck (FN) was measured. The distribution of the genetic polymorphisms, including rs1799814 and rs1048943 at CYP1A1 as well as rs1056836 at CYP1B1, were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), single-stranded conformational polymorphism (SSCP), and DNA sequencing...
March 16, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28300464/serum-visfatin-vascular-endothelial-growth-factor-and-matrix-metalloproteinase-9-in-women-with-polycystic-ovary-syndrome
#4
Kalliopi Dambala, Dimitrios Vavilis, Eleni Bili, Dimitrios G Goulis, Basil C Tarlatzis
AIM: To evaluate serum concentrations of visfatin, vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in women with polycystic ovary syndrome (PCOS) and to investigate their possible role as early endothelial markers in PCOS. METHODS: Forty-two women with PCOS and 42 controls, matched for age and weight, were included in the study. Serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, total testosterone (tT), Δ4-androstenedione (Δ4A), dehydroepinadrosterone sulphate (DHEA-S), 17-OH-progesterone, sex hormone-binding protein (SHBG), thyroid-stimulating hormone (TSH), free thyroxine (fT4), visfatin, VEGF and MMP-9 were measured in all women; free androgen index (FAI) was calculated as well...
March 16, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277886/can-we-alter-pregnancy-outcome-by-adjusting-progesterone-treatment-at-mid-luteal-phase-a-randomized-controlled-trial
#5
Nardin Aslih, Adrian Ellenbogen, Tal Shavit, Medeia Michaeli, Devora Yakobi, Einat Shalom-Paz
Our study aimed to determine whether mid-luteal serum P concentrations can serve as a predictive factor for in vitro fertilization (IVF) outcomes and whether increasing P dosage for patients with low levels at mid-luteal phase may improve pregnancy rates. It was a prospective, randomized controlled study. A total of 146 patients undergoing IVF treatment were prospectively enrolled and received routine luteal phase support (LPS) regimen of Endometrin® (progesterone) 200 mg/day. Serum P levels were measured 7 days after embryo transfer (ET)...
March 9, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277814/the-cutoff-values-of-serum-amh-levels-and-starting-recfsh-doses-for-the-individualization-of-ivf-treatment-strategies
#6
Pinar Özcan, Cem Fiçicioğlu, Seda Ateş, Meltem Güner Can, Çiğdem Kaspar, Oya Akçin, Mert Yesiladali
OBJECTIVE: The main purpose of our study is to categorize starting doses of recombinant follicle-stimulating hormone (recFSH) based on various cutoff values of anti-Mullerian hormone (AMH) and to determine the effectiveness of serum AMH levels in the prediction of poor ovarian response. MATERIAL AND METHODS: Prospective data analysis was conducted at IVF center. A total of 323 patients were included. All patients were divided into four groups according to the patients' serum AMH concentrations: Group 1 (AMH < 1 ng/ml; 450 IU/day n = 157); Group 2 (AMH 1-2 ng/ml; 375 IU/day, n = 55); Group 3 (AMH 2-3 ng/ml; 225 IU/day, n = 48); and Group 4 (AMH > 3 ng/ml; 150 IU/day, n = 63)...
March 9, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28266237/frozen-embryo-transfer-cycles-in-women-with-deep-endometriosis
#7
George Queiroz Vaz, Alessandra Viviane Evangelista, Maria Cecilia Almeida Cardoso, Paulo Gallo, Maria Cecilia Erthal, Marco Aurelio Pinho Oliveira
OBJECTIVE: To compare the transfer pregnancy rates with frozen embryos from patients with deep endometriosis and non-endometriosis patients. METHODS: We conducted a retrospective cohort study of review of medical records of 181 women aged 18-40 years, undergoing transfer of frozen embryos into a fertility center. The data collected was from January 2007 to December 2013. RESULTS: Regarding the patients with endometriosis, there was no statistical difference in proportion to compare polycystic ovarian syndrome, male factor, tubal factor and unexplained infertility...
March 7, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28266234/postoperative-desogestrel-for-pelvic-endometriosis-related-pain-a-randomized-controlled-trial
#8
Prasong Tanmahasamut, Ratikorn Saejong, Manee Rattanachaiyanont, Surasak Angsuwathana, Kitirat Techatraisak, Nutchaya Sanga-Areekul
OBJECTIVE: To determine the effectiveness of desogestrel for relieving endometriosis-related pain. METHODS: A double-blinded randomized placebo-controlled trial was conducted in 40 patients who had endometriosis with moderate-to-severe dysmenorrhea or chronic pelvic pain undergoing laparoscopic conservative surgery. After surgery, patients were randomized to desogestrel or placebo group. Outcomes included changes in visual analog scale (VAS) of dysmenorrhea, pelvic pain and dyspareunia, patient satisfaction, and adverse effects...
March 7, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28266227/kisspeptin-a-new-marker-for-human-pre-ovulation
#9
Junyu Zhai, Lingling Ding, Shigang Zhao, Weiping Li, Yinhua Sun, Shizhen Su, Jiangtao Zhang, Han Zhao, Zi-Jiang Chen
Kisspeptin is a polypeptide that plays an important role in reproductive endocrine regulation. The aim of present study was to investigate the dynamic trend of kisspeptin levels during the menstrual cycle and to elucidate the relationship between kisspeptin ovulation. First, 15 female volunteers with regular menstrual cycles were recruited to detect the change in serum and urine kisspeptin levels over one menstrual cycle within each individual. Subsequently, 114 serum samples and 79 urine samples from 114 individuals were randomly collected at the outpatient department to better ascertain the results...
March 7, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277105/the-induction-of-ovulation-by-pulsatile-administration-of-gnrh-an-appropriate-method-in-hypothalamic-amenorrhea
#10
Fotini Christou, Nelly Pitteloud, Fulgencio Gomez
The induction of ovulation by the means of a pump which assures the pulsatile administration of GnRH is a well-known method that applies to women suffering from amenorrhea of hypothalamic origin. Although a simple and efficient method to establish fertility, it is underused. Twelve patients suffering from this condition, 1 Kallmann syndrome, 4 normosmic isolated hypogonadotropic hypogonadism, and 7 functional hypothalamic amenorrhea desiring pregnancy were treated. They underwent one or more cycles of pulsatile GnRH, at a frequency of 90 minutes, either by the intravenous or the subcutaneous route...
March 6, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277104/self-diagnosis-of-hyperparathyroidism-during-pregnancy-resulting-in-parathyroidectomy-and-uncomplicated-delivery
#11
Aleksandra Medza, Lukasz Obolonczyk, Anna Lewalska, Tomasz Buss, Rafal Peksa, Malgorzata Siekierska-Hellmann, Monika Berendt-Obolonczyk, Piotr Wisniewski, Krzysztof Sworczak
Primary hyperparathyroidism is a condition with hypercalcemia and elevated parathyroid hormone (PTH). Typically, treating patients with such disease does not pose a problem for doctors, unless the patient is pregnant. Firstly, pregnancy may mask signs of hypercalcemia. Secondly, treatment should be applied with special care for immature fetus. If undiagnosed and untreated, it is life-threatening for the mother and the baby. The main cause of primary hyperparathyroidism is parathyroid adenoma, which should be removed surgically in second trimester...
March 6, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277109/thyroid-peroxidase-identified-in-human-granulosa-cells-another-piece-to-the-thyroid-ovary-puzzle
#12
Patrizia Monteleone, Pinuccia Faviana, Paolo Giovanni Artini
Thyroid hormones seemingly influence the maturation of the human oocyte. Thyroid hormone receptors have been isolated in granulosa mural and cumulus cells and the mature oocyte of the human ovarian follicle. Thyroid hormones are present in follicular fluid in concentrations similar to those in serum. Most importantly, enzymes involved in the chain that regulate the generation of thyroid hormones have been found in granulosa cells. For the first time, we have isolated thyroid peroxidase by immunocytochemistry in the granulosa cumulus cells of the human ovarian follicle, thereby supporting the hypothesis that the human ovarian follicle may be an independent thyroid-hormone producing unit...
March 5, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277108/temporal-effects-of-human-chorionic-gonadotropin-on-expression-of-the-circadian-genes-and-steroidogenesis-related-genes-in-human-luteinized-granulosa-cells
#13
Minghui Chen, Yanwen Xu, Benyu Miao, Hui Zhao, Jun Gao, Canquan Zhou
OBJECTIVE: It has been shown in animal models that circadian clock exists in corpora luteum which is essential for maintaining pregnancy. However, it is unknown whether circadian clock exists in corpora luteum and its relation with steroidogenesis in human ovary. STUDY DESIGN: Human luteinized granulosa cells from patients who underwent in vitro fertilization treatment were purified and cultured in vitro. Accumulation patterns of circadian gene and steroidogenesis-related gene mRNAs in human luteinized granulosa cells were observed during the 48 hours after treatment with human chorionic gonadotropin (hCG) by quantitative PCR...
March 5, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277107/gender-age-and-time-dependent-dosing-of-growth-hormone-in-adults-real-world-data-from-a-decade-of-clinical-practice-in-germany
#14
Peter H Kann, Simona Bergmann, Günter K Stalla, Christina Dimopoulou, Matthias M Weber, Birgitte T Pedersen, Stefanie Meckes-Ferber
We evaluated treatment patterns and gender-dependent dosing of growth hormone (GH) substitution in adults with GH deficiency (AGHD). Data on GH dose were collected (2003-2013) from 509 GH-treated patients (mean age: 48.9 years; 47% female) enroled in the observational German NordiWin study (NCT01543880). The impact of gender, age, treatment duration and calendar year on GH treatment patterns was evaluated by multiple regression analysis. Mean (SD) baseline GH dose (mg/day) was similar between females (0...
March 5, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277106/premenstrual-syndrome-and-fibromyalgia-the-frequency-of-the-coexistence-and-their-effects-on-quality-of-life
#15
Feray Soyupek, Cigdem Aydogan, Mehmet Guney, Seyit Ali Kose
OBJECTIVE: We aimed to investigate the association between Premenstrual syndrome (PMS) and fibromyalgia syndrome (FMS), to assess common symptoms and quality of life (QOL) of them. METHODS: Patients with PMS formed the PMS group and age-matched healthy normal controls were included in the control group. The diagnosis of the FMS and PMS were based on new American College of Rheumatology FMS criteria and DSM-IV PMS criteria. FMS-related symptoms assessed by visual analog scale and number of tender points (TePs) were analyzed...
March 5, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277113/mild-versus-conventional-antagonist-ovarian-stimulation-protocols-in-expected-normal-responders-undergoing-ivf-icsi-a-case-control-study
#16
Charalampos Siristatidis, Konstantinos Dafopoulos, Tereza Vrantza, George Salamalekis, George Basios, Paraskevi Vogiatzi, Vasileios Pergialiotis, Nikolaos Papantoniou
Mild controlled ovarian hyperstimulation (COH) protocols combining clomiphene citrate (CC) or letrozole with gonadotropins were introduced as an effective alternative of conventional COH in normal responders undergoing IVF/ICSI. In this case-control study, we compared 41 participants treated with a mild stimulation protocol receiving gonadotropins combined with either CC (n = 24) or letrozole (n = 17) with 71 subfertile participants with matching baseline characteristics, conforming with the same inclusion criteria and treated with a conventional antagonist protocol...
March 3, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277112/myo-inositol-administration-positively-effects-ovulation-induction-and-intrauterine-insemination-in-patients-with-polycystic-ovary-syndrome-a-prospective-controlled-randomized-trial
#17
Özlen Emekçi Özay, Ali Cenk Özay, Erkan Çağlıyan, Recep Emre Okyay, Bülent Gülekli
Objectıve: The aim of the study is to investigate the effect of myo-inositol (MYO) on pregnancy rates of patients diagnosed with polycystic ovary syndrome (PCOS) who undergone controlled ovulation induction and intrauterine insemination (IUI). METHODS: A total of 196 infertile patients diagnosed with PCOS and admitted to Dokuz Eylul University Faculty of Medicine were included in the study between March 2013 and May 2016. The patients in group 1 (n = 98) were given 4 g MYO and 400 μg folic acid before and during ovulation induction...
March 3, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277111/inter-cycle-and-inter-observer-variability-of-the-antral-follicle-count-in-routine-clinical-practice
#18
Jessica Subirá, Jose Alberola-Rubio, María Jose Núñez, Alicia Marzal Escrivá, Antonio Pellicer, Vicente Montañana, César Díaz-García
Antral follicle count (AFC) is a reliable predictor of ovarian response to stimulation and its inter-cycle and inter-observer variability has been extensively studied on in vitro fertilization (IVF), mostly in highly selected populations within studies not originally designed for this purpose. In this retrospective cohort study, we assess the inter-cycle variation of AFC in a setting similar to that of the daily practice. We included only patients undergoing mild stimulation for intrauterine insemination (IUI)...
March 3, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277110/effect-of-normal-sperm-morphology-rate-nsmr-on-clinical-outcomes-for-rescue-icsi-r-icsi-patients
#19
Mingzhao Li, Hui Wang, Wei Li, Juanzi Shi
PURPOSE: To investigate whether the normal sperm morphology rate (NSMR) can affect the clinical outcomes of rescue-ICSI(R-ICSI) patients. METHODS: Based on different NSMR, the patients were divided into two groups as follows: NSMR < 4% and NSMR ≥ 4% group. Main outcomes compared were fertilization, cleavage, normal fertilization, high-quality embryo, transferrable embryo, no transferrable embryo cycles, implantation, clinical pregnancy and abortion rate...
March 3, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277116/regulation-of-endometrial-cell-proliferation-by-estrogen-induced-bdnf-signaling-pathway
#20
Fangzheng Dong, Qiyao Zhang, Wei Kong, Jun Chen, Junlan Ma, Li Wang, Yanian Wang, Yan Liu, Yan Li, Ji Wen
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin growth factors family. Recent studies indicated that the level of BDNF in follicular fluid is a marker for oocyte quality and infertility. Here, we intend to further investigate the function of BDNF and its signaling pathway in the regulation of endometrial cells proliferation. We found that BDNF is a critical growth factor in endometrial cells. Activation of signal transducer and activator of transcription 3 signaling pathway is required for BNDF-regulated endometrial cell proliferation...
March 2, 2017: Gynecological Endocrinology
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