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Gynecological Endocrinology

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https://www.readbyqxmd.com/read/28749309/correction-to-stracquadanio-and-ciotta-low-birth-weight-is-a-pcos-risk-factor-for-southern-italian-women
#1
(no author information available yet)
No abstract text is available yet for this article.
July 27, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28749253/randomized-crossover-study-investigating-daily-versus-on-demand-vulvar-visnadine-spray-in-women-affected-by-female-sexual-arousal-disorder
#2
Salvatore Caruso, Diletta Mauro, Maria Cariola, Valentina Fava, Agnese Maria Chiara Rapisarda, Antonio Cianci
The aim of the study was to verify the efficacy of vulvar Visnadine spray in premenopausal women affected by female sexual arousal disorder (FSAD). Thirty-eight women aged 25-40 years affected by FSAD were enrolled in the randomized crossover study, by two possible sequences: on-demand, washout, daily (A sequence); and daily, washout, on-demand (B sequence). The Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale (FSDS) were used to assess sexual function and sexual distress, respectively...
July 27, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28723303/folate-serum-levels-in-italian-women-entering-an-in-vitro-fertilization-program
#3
Adalisa Ponzano, Gian Mario Tiboni
Italian public health authorities recommend women of childbearing age to assume a daily dose of 0.4 mg of folic acid (FA) from at least one month before conception in order to reduce the risk of having children affected by neural tube defects (NTDs). In this study, folate, homocysteine and vitamin B12 serum levels were determined in 77 women entering an in vitro fertilization program. About 75% of patients had serum folate values compatible with the intake of the recommended dose of FA for at least three months, whereas only the 61% of them reached or exceeded the serum folate concentration regarded as the optimal concentration during the periconceptional period...
July 19, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28704124/%C3%AE-cell-function-and-insulin-resistance-in-lean-cases-with-polycystic-ovary-syndrome
#4
Arunkumar R Pande, Ashwani Kumar Guleria, Sudhanshu Dev Singh, Manoj Shukla, Preeti Dabadghao
Obesity is a major factor in development of insulin resistance (IR) and metabolic features in polycystic ovary syndrome (PCOS) patients. Nearly two-thirds patients with PCOS (30 of 37 confirmed cases of PCOS) in our previous community based study were lean, in contrast to Caucasians. Metabolic parameters including IR and β cell function have not been characterized well in this group of lean PCOS. To study the metabolic features including IR and β cell function in lean PCOS patients, 53 patients with BMI, <23 kg/m(2) were compared with 71 obese PCOS and 45 age and body mass index matched controls...
July 13, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28696807/association-between-polycystic-ovary-syndrome-and-the-risk-of-stroke-and-all-cause-mortality-insights-from-a-meta-analysis
#5
Yaqiong Zhou, Xiaoyun Wang, Yongrong Jiang, Honglan Ma, Li Chen, Chenglin Lai, Chunrong Peng, Caiyun He, Chaofeng Sun
Many epidemiologic literatures have investigated the link between PCOS and long-term stroke risk and all-cause mortality, but the results are surprisingly conflicting. A meta-analysis was performed to examine the link between polycystic ovary syndrome (PCOS) and the risk of stroke, death from any cause, and assessed whether BMI might explain a higher risk of stroke. We searched the PUBMED, EMBASE, and Cochrane Library databases with no restrictions. Nine Cohort studies were identified, involving a total of 237,647 subjects...
July 11, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28682646/embryo-pooling-a-promising-strategy-for-managing-insufficient-number-of-embryos-in-preimplantation-genetic-diagnosis
#6
Xiaokun Hu, Chenhui Ding, Duoduo Zhang, Wen Zhou, Jing Wang, Yanhong Zeng, Jie Lv, Yan-Wen Xu, Can-Quan Zhou
This retrospective study evaluated the embryo pooling strategy for managing insufficient number of embryos in preimplantation genetic diagnosis (PGD) through serial vitrification of cleavage-stage embryos from consecutive cycles, and simultaneous blastocysts biopsy in combination with blastocysts obtained in ultimate fresh cycle. A retrospective analysis of the cumulative pregnancy rate of 68 patients underwent cleavage-stage embryos accumulation (Embryo Pooling Group) and 94 patients underwent one stimulation cycle (Control Group) over a 2-year period were conducted...
July 6, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28678568/testosterone-is-associated-with-insulin-resistance-index-independently-of-adiposity-in-women-with-polycystic-ovary-syndrome
#7
Kari Luotola, Terhi T Piltonen, Johanna Puurunen, Laure C Morin-Papunen, Juha S Tapanainen
OBJECTIVE: To study the associations between androgens, glucose homeostasis, inflammation and statin treatment in women with polycystic ovary syndrome (PCOS). DESIGN AND METHODS: Oral glucose tolerance tests, androgens, hs-CRP and interleukin-1 receptor antagonist (IL-1Ra) were analyzed at baseline and after 6 months of atorvastatin (20 mg/d) or placebo treatment in 27 women with PCOS. RESULTS: Testosterone associated with insulin resistance measured with ISIMatsuda independently of BMI, age and SHBG concentrations and the full model, including IL-1Ra, hs-CRP and HDL-C, also showed independency of BMI and waist circumference (p ≤ ...
July 5, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28675713/obesity-in-pregnancy-as-a-model-to-identify-women-at-risk-for-later-metabolic-syndrome
#8
C Neri, C Di Cesare, A Labianca, M Viggiano, A Caruso, G Paradisi
The aim of our study is to identify - in a cohort of obese women - cardiovascular and clinical risk factors in women with previous complicated pregnancies and protective factors in women with previous physiological pregnancies. A total of 135 nonpregnant obese women referring to Policlinico Gemelli in Rome were prospectively collected in 2009-2010. Thirty-two women matched inclusion criteria: 16 reported a previous physiological pregnancy and 16 reported previous obstetric complications. A clinical, instrumental and laboratory evaluation has been performed for each patient...
July 4, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28675705/assessment-of-insulin-resistance-in-chinese-pcos-patients-with-normal-glucose-tolerance
#9
Jing Gao, Li Zhou, Jie Hong, Chen Chen
The study aimed to investigate insulin resistance (IR) status in polycystic ovary syndrome (PCOS) women with normal glucose tolerance (NGT), and further to evaluate feasible diagnostic method for those patients. Three hundred and twenty-five PCOS women with NGT and ninety-five healthy age-matched controls were recruited with Rotterdam criterion and 75 g oral glucose tolerance test (OGTT). IR status was estimated following a glycemic and insulinemic OGTT (0, 30, 60, 120, and 180 min). A modified HOMA-IR formula was applied to each time-course value of glycemia and insulinemia...
July 4, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28675704/the-metabolic-syndrome-is-associated-with-carotid-atherosclerosis-and-arterial-stiffness-in-asymptomatic-nondiabetic-postmenopausal-women
#10
Irene Lambrinoudaki, Aikaterini Kazani, Eleni Armeni, Demetrios Rizos, Areti Augoulea, Georgios Kaparos, Andreas Alexandrou, Georgios Georgiopoulos, Ioannis Kanakakis, Kimon Stamatelopoulos
The menopause transition is associated with adverse changes in cardiometabolic risk factors. We aimed to examine the association of the metabolic syndrome (MS) and its features with indices of vascular structure and function in a population of asymptomatic postmenopausal women. A total of 473 informed-consenting, nondiabetic postmenopausal women were included in the study. The MS was defined according to the Joint Definition. We evaluated the association between the presence of MS and indices of vascular structure (carotid artery intima-media thickness (IMT); atherosclerotic plaques) and function (flow-mediated dilatation (FMD); pulse wave velocity (PWV))...
July 4, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28670921/progesterone-progesterone-estradiol-and-art-outcomes-in-day-5-transfer-cycles
#11
Ritika Arora, Crystal Chan, Xiang Y Ye, Ellen M Greenblatt
The objective of this study was to assess the effects of elevated luteal-phase progesterone levels (PE) and high progesterone/estradiol ratio ('P/E2' ratio) on IVF outcomes, exclusively in GnRH-antagonist cycles with day-5 embryo transfer. PE was not found to have a significant effect on implantation or clinical pregnancy rate (CPR) (OR 0.56, 95% CI 0.25-1.25, p = .16). Elevated 'P/E2' ratio (≥0.55) on trigger day was associated with a poorer response to stimulation and lower clinical pregnancy rates (OR 0...
July 2, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28656791/impact-of-laparoscopy-on-the-biological-behavior-and-gene-expression-of-endometrial-adenocarcinoma-cells
#12
Shouguo Huang, Jie Qin, Jin Chen, Hong Cheng, Qiu Meng, Jing Zhang, Haiyan Wang
The current study investigated the effect of laparoscopy on the biological behavior and gene expression of endometrial adenocarcinoma cells. Totally, 40 patients with stage I endometrial adenocarcinoma and 20 patients with benign uterine diseases were enrolled in this study. For patients with endometrial adenocarcinoma, laparoscopy was performed in 20 cases and laparotomy was carried out in the other 20 cases. Total laparoscopic hysterectomy was performed in patients with benign diseases. Cell apoptotic rate and the gene expression of N-myc, Fas, metastasis-associated protein 1 (MTA1), and nm23-H1 were determined in the normal and cancerous endometrial tissues both preoperatively and postoperatively...
June 28, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28650773/a-successful-live-birth-with-in-vitro-fertilization-and-thawed-embryo-transfer-after-conservative-treatment-of-recurrent-endometrial-cancer
#13
Sung Woo Kim, Hoon Kim, Seung-Yup Ku, Chang Suk Suh, Seok Hyun Kim, Young Min Choi
Estrogen-dependent early stage endometrial cancer is relatively common in young women of reproductive age. The standard treatment is hysterectomy and bilateral salpingo-oophorectomy (BSO), even in early stage well-differentiated endometrial cancer patients. This surgical option results in permanent loss of fertility. There have been some reports of live births using in vitro fertilization after conservative management of endometrial cancer with high-dose progestin for the purpose of fertility preservation. However, most were not recurrent cases and pregnancy was achieved through conventional in vitro fertilization, which usually raises serum estradiol levels and may lead to the recurrence of endometrial cancer...
June 26, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28649890/alteration-of-ghrelin-obestatin-ratio-in-adolescence-with-polycystic-ovarian-syndrome
#14
Weiguang Wu, Xiaobin Fan, Yuecheng Yu, Zheng Wang, Yingchun Wang
Ghrelin, an endoggenous for the growth hormone secretagogue receptor, has been shown to participate in the regulation of energy homeostasis and pituitary hormone secretion. Obestatin, encoded by the same gene as ghrelin, is described as a physiological opponent of ghrelin. Ghrelin and obestatin are altered in polycystic ovary syndrome (PCOS), which is characterized by insulin resistance and pituitary hormone secretion disorder. The aim of this study was to evaluate ghrelin/obestatin imbalance in relation to insulin resistance and pituitary hormone in adolescence with PCOS...
June 24, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28649885/can-the-source-of-hyperandrogenism-in-adolescents-with-polycystic-ovary-syndrome-predict-metabolic-phenotype
#15
Alaa Al Nofal, Lyndsay D Viers, Asma Javed
In this study, we demonstrated an association between adrenal hyperandrogenism, as determined by dehydroepiandrostenedione-to-free testosterone (DHEA-S/FT) ratio, and metabolic phenotype in obese and lean adolescents with polycystic ovary syndrome (PCOS). We compared 64 overweight/obese adolescents with PCOS (PCOS-O) with 18 lean (PCOS-L) adolescents. We analyzed the association between DHEA-S/FT ratios and metabolic parameters. Patients in the PCOS-O group were younger (median [interquartile range]) than those in the PCOS-L group (15 [15-17] vs...
June 24, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28649879/a-protocol-for-ovulation-delay-in-women-who-cannot-use-estrogen-including-jewish-women-with-niddah-issues-and-a-pilot-study
#16
Benjamin S Rehany, Michael H Dahan
Orthodox Jewish women abstain from sexual intercourse from the commencement of menstruation until seven days after the end of menstrual bleeding at which point they can immerse themselves in a ritual bath and recommence relations. For women who ovulate prior to commencing intercourse this results in religious infertility. The traditional treatment for religious infertility is oral estrogens in the early follicular phase to delay ovulation. However, certain groups of women have contraindications to oral estrogens...
June 24, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28644709/pcos-and-diabetes-mellitus-from-insulin-resistance-to-altered-beta-pancreatic-function-a-link-in-evolution
#17
Rosita A Condorelli, Aldo E Calogero, Maurizio Di Mauro, Sandro La Vignera
No abstract text is available yet for this article.
June 23, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28617148/outcomes-of-ivf-cycles-coupled-with-pgs-by-acgh-of-embryos-from-donor-and-autologous-oocytes-transferred-after-vitrification-to-women-of-advanced-maternal-age
#18
Elena M Fedorova, Svetlana A Shlykova, Ksenia V Shunkina, Olga G Zaitceva, Elena N Lapina, Taras V Yanchuk, Alla S Kalugina
It is well documented that aneuploidy rate in preimplantation embryos increases with the mother's age, and at the same time the number of oocytes diminishes. Consequently, for patients of advanced maternal age two options are available to overcome these limitations: use of oocytes from young donors, or use of own oocytes coupled with preimplantation genetic screening (PGS) for 24 chromosomes. However, it is not clear which strategy might be more effective. The aim of this retrospective study was to evaluate outcomes of IVF cycles coupled with transfer of vitrified embryos from donor or autologous oocytes, both with or without PGS...
June 15, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28609197/the-glu331del-mutation-in-the-cyp17a1-gene-causes-atypical-congenital-adrenal-hyperplasia-in-a-46-xx-female
#19
Giulia Lanzolla, Giuseppe Vancieri, Silvia Lanciotti, Federica Sangiuolo, Elisa Menegatti, Luca Federici, Costanzo Moretti, Francesco Brancati
17α-Hydroxylase deficiency is an uncommon type of congenital adrenal hyperplasia (CAH) caused by mutations in the CYP17A1 gene encoding both 17α-hydroxylase and 17,20-lyase, essential for sex steroids production. Main clinical features include lack of pubertal development, hypertension, and hypokalemia. We report the first case of a 46,XX female homozygote for the p.Glu331del mutation in the CYP17A1 gene showing an atypical clinical presentation. She was evaluated the first time for primary amenorrhea and delayed puberty in the presence of low levels of androgens, 17β-estradiol, serum cortisol, and high levels of progesterone and gonadotropins...
June 13, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28609128/the-effect-of-different-progestogens-on-sleep-in-postmenopausal-women-a-randomized-trial
#20
Ekachai Leeaunkulsathean, Tawiwan Pantasri, Somsak Chaovisitseree, Nuntana Morakot
BACKGROUND: While progesterone affects sleep, different types of it might affect sleep differently. METHODS: One hundred Thai women, who complained of insomnia, visited the Menopause Clinic at Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Thailand from February 2014 to March 2015, and were divided randomly into two groups. Both groups received daily hormonal treatment that included estradiol valerate (progynova) at 1 mg. The first group also received dydrogesterone (duphaston(®)) at 10 mg and the second group micronized progesterone (utrogestran(®)) at 100 mg...
June 13, 2017: Gynecological Endocrinology
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