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Gynecological Endocrinology

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https://www.readbyqxmd.com/read/28937296/comparison-of-e-cadherin-with-stat3-and-apoptosis-regulators-bak-and-bcl-xl-in-endometrioid-adenocarcinomas-of-different-er-alpha-immunoprofile
#1
Urszula Sulkowska, Andrzej Wincewicz, Luiza Kanczuga-Koda, Mariusz Koda, Stanislaw Sulkowski
E-cadherin is a factor of good prognosis in endometrioid adenocarcinomas, while STAT3 is an oncogenic driver of carcinogenesis. E-cadherin, Bak, Bcl-xL and STAT3 were immunohistochemically detected in 78 human endometrioid adenocarcinomas. E-cadherin correlated with STAT3 (p <. 001, r = 0.537) as well as Bak (p = .005, r = 0.314) and Bcl-xL (p = .002, r = 0.340) in the whole study group. In G2 tumors, E-cadherin associated with Bak (p = .021, r = 0.319), Bcl-xL (p = .026, r = 0...
September 22, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28937295/adropin-levels-in-women-with-polycystic-ovaries-undergoing-ovarian-stimulation-correlation-with-lipoprotein-lipid-profiles
#2
Artemis Bousmpoula, Evangelia Kouskouni, Evangelos Benidis, Styliani Demeridou, Rachil Kapeta-Kourkouli, Anthia Chasiakou, Stavroula Baka
This study aimed to investigate serum and follicular fluid (FF) adropin levels in polycystic ovary syndrome (PCOS) and normal women undergoing controlled ovarian stimulation and correlate them with the lipid and lipoprotein levels. We included 60 women (30 lean and 30 overweight) with diagnosed PCOS, and 60 age and weight-matched non-PCOS controls (30 lean and 30 overweight), under in vitro fertilization (IVF) treatment. Serum lipid and lipoprotein levels were assessed by the Abbott Architect c8000 autoanalyzer while adropin levels were determined by enzyme immunoassay...
September 22, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28937294/hypertensive-crisis-in-pregnancy-due-to-a-metamorphosing-pheochromocytoma-with-postdelivery-cushing-s-syndrome
#3
Katharina Langton, Matthias Gruber, Jimmy Masjkur, Charlotte Steenblock, Mirko Peitzsch, Jörn Meinel, Jacques Lenders, Stefan Bornstein, Graeme Eisenhofer
Pheochromocytomas in pregnancy are rare but potentially lethal. Even rarer is the combination of pheochromocytoma in pregnancy with subsequent development of ectopic Cushing's syndrome. We report a 36-year-old woman, previously diagnosed with essential hypertension, who developed severe hypertension in pregnancy complicated by insulin-dependent gestational diabetes. A cesarean section was performed at 32 weeks following a hypertensive crisis after routine administration of betamethasone. Postnatal persistence of signs and symptoms of catecholamine excess led to the diagnosis of a left adrenal pheochromocytoma...
September 22, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28933575/unexpected-uterine-leiomyosarcoma-in-a-woman-with-multiple-myomas-treated-with-ulipristal-acetate-case-report-and-literature-review
#4
Paola Modaffari, Marta D'alonzo, Marta Garbagnati, Silvia Pecchio, Guido Menato, Nicoletta Biglia
Ulipristal acetate (UPA) has been recognized as an alternative strategy to surgery in the management of symptomatic women with uterine fibroids. We present a case report on a woman with hereditary fibrinogen deficiency exclusively treated with UPA for myoma-related menorrhagia and abdominal pain, who subsequently underwent a hysterectomy because of clinical worsening. A FIGO IB uterine leiomyosarcoma was found among multiple myomas. A review of the literature found two other cases of uterine leiomyosarcoma in patients treated with UPA: clinical data are reported...
September 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28933574/is-there-a-role-for-kisspeptin-in-pathogenesis-of-polycystic-ovary-syndrome
#5
Umit Gorkem, Cihan Togrul, Emine Arslan, Ayla Sargin Oruc, Nuriye Buyukkayaci Duman
AIM: To investigate association of kisspeptin levels in infertile women with different ovarian reserve patterns. MATERIALS AND METHODS: In this prospective cross-sectional study, 157 participants were recruited. The women were divided into three groups: (i) adequate ovarian reserve (AOR) (n = 57), (ii) high ovarian reserve (PCOS) (n = 60), (iii) diminished ovarian reserve (DOR) (n = 40). Weight, height, waist circumference (WC), hip circumference (HC), body mass index (BMI), waist/hip ratio (WHR) were measured...
September 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28933569/day-two-post-retrieval-1500-iui-hcg-bolus-progesterone-free-luteal-support-post-gnrh-agonist-trigger-a-proof-of-concept-study
#6
Sharon Vanetik, Linoy Segal, Tatiana Breizman, Shahar Kol
Small dose of hCG (1500 IU) on the day of oocyte retrieval, followed by daily progesterone administration, is currently the preferred way to secure adequate luteal support following GnRH agonist trigger. In the current proof-of-concept study, we explored the possibility that a bolus of 1500 IU hCG, given two days after oocyte retrieval, may be sufficient to sustain adequate luteal support without additional progesterone treatment. From February 2015 to August 2016, we obtained 44 pregnancies following GnRHa trigger followed by day 2 hCG (1500 IU) support only (study group)...
September 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28925774/resolution-of-dopamine-agonist-resistant-hyperprolactinemia-by-hysterectomy-a-case-report
#7
Hiroshi Sato, Yuna Asami, Reona Shiro, Miki Yasuda, Saeko Imai, Rie Sakai, Kenji Oida, Kanako Kawaharamura, Nao Taguchi, Takako Suzuki, Masaya Hirose
Prolactin-producing uterine leiomyomas are very rare. Although hyperprolactinemia rapidly improves after removal of such leiomyomas, no preoperative diagnostic test has been established for prolactin-producing uterine leiomyomas. A 45-year-old Japanese woman, gravida 3 para 3, was referred to our hospital for further examination of hyperprolactinemia resistant to a dopamine agonist. A pituitary prolactinoma was undetectable by brain magnetic resonance imaging. A bromocriptine loading test revealed an increased serum prolactin concentration after loading...
September 19, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28925767/anterior-abdominal-wall-parasitic-leiomyoma-case-report
#8
María Fernanda Garrido Oyarzún, Adela Saco, Camil Castelo-Branco
The leiomyomas are a common gynecologic entity that may present unusual growth patterns or unusual locations. Its atypical presentations creates a diagnostic challenge. This is a case report of a parasitic leiomyoma located in the anterior abdominal wall in a 53 years old woman with pelvic compressive and urinary symptoms, with no history of any gynecological surgery. This case illustrates the diagnostic difficulties and describes the complementary images used in the preoperative evaluation.
September 19, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28925754/plasma-urocortin-1-as-a-preoperative-marker-of-endometriosis-in-symptomatic-women
#9
Laura M Maia, Ana L Rocha, Helen L Del Puerto, Felice Petraglia, Fernando M Reis
Accurate noninvasive diagnostic tests for endometriosis are still missing. This study evaluated the predictive value of the neuropeptide urocortin 1 (Ucn1) to detect pelvic endometriosis in symptomatic women. We enrolled prospectively 97 consecutive women submitted to gynecologic laparoscopy for chronic or acute pelvic pain, infertility or adnexal mass. Preoperative blood samples were assayed for Ucn1 using enzyme immunoassay. Patients with endometriosis had higher plasma Ucn1 levels compared to patients with no lesions (median 59 vs...
September 19, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28868943/evaluation-of-pro-oxidant-antioxidant-balance-pab-and-its-association-with-inflammatory-cytokines-in-polycystic-ovary-syndrome-pcos
#10
T Artimani, J Karimi, M Mehdizadeh, M Yavangi, E Khanlarzadeh, M Ghorbani, S Asadi, N Kheiripour
Chronic low-grade inflammation has been suggested as a key contributor of the pathogenesis and development of polycystic ovary syndrome (PCOS). To investigate the association between oxidative stress status and inflammatory cytokines in follicular fluid of 21 PCOS women compared to 21 women with normal ovarian function who underwent intra-cytoplasmic sperm injection. Concentration of IL-6, IL-8, IL-10, and TNF-α was measured using sandwich ELISA. Oxidative stress was examined by measuring total oxidant status (TOS), malondialdehyde (MDA), total antioxidant capacity (TAC), and thiol groups...
September 4, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28868946/vitamin-d-receptor-gene-polymorphisms-and-risk-of-polycystic-ovary-syndrome-in-south-indian-women
#11
Swapna Siddamalla, Tumu Venkat Reddy, Suresh Govatati, Nagendram Erram, Mamata Deenadayal, Sisinthy Shivaji, Manjula Bhanoori
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of reproductive age women. Emerging evidence suggests that Vitamin D Receptor (VDR) might be a causal factor for characteristics associated with PCOS such as obesity and type 2 diabetes. Present study investigated association between VDR gene BsmI A/G (rs1544410), ApaI A/C (rs7975232) and TaqI T/C (rs731236) single nucleotide polymorphisms and PCOS risk in South Indian women. Genotyping of VDR gene SNPs was carried out in PCOS patients (n = 95) and controls (n = 130) by PCR-RFLP method and confirmed by sequencing analysis...
September 3, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28868939/characterization-of-a-suboptimal-ivf-population-and-clinical-outcome-after-two-ivf-cycles
#12
Beatriz Alvaro Mercadal, Ignacio Rodríguez, Gemma Arroyo, Francisca Martínez, Pedro Nolasco Barri, Buenaventura Coroleu
The number of oocytes retrieved in in vitro fertilization (IVF) cycles is an independent factor influencing pregnancy rate (PR), and optimal number of oocytes would be between 10 and 15. This has led to the hypothesis that the identification of a suboptimal group of responders beforehand (4-9 oocytes retrieved) would allow physicians to optimize their PR. A retrospective observational study counting on 735 women doing an IVF treatment in our center was performed. Multivariable logistic regression was used to analyze the relationship between anti-Mullerian hormone (AMH) and antral follicle count (AFC), within suboptimal and optimal responders...
September 3, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28857628/correlation-between-allopregnanolone-levels-and-depressive-symptoms-during-late-menopausal-transition-and-early-postmenopause
#13
Radoslaw Slopien, Nicola Pluchino, Alina Warenik-Szymankiewicz, Stefan Sajdak, Michele Luisi, Panagiotis Drakopoulos, Andrea R Genazzani
OBJECTIVES: This observational, cross-sectional study included 140 women with climacteric symptoms. The aim of the study was to evaluate the correlation between the presence and severity of depressive symptoms and allopregnanolone levels in women during late menopausal transition and early postmenopause. METHODS: The study group was divided into two groups: 45 women in late menopausal transition and 95 early postmenopausal women. We evaluated Kupperman index, Hamilton scale and serum follicle-stimulating hormone, luteinizing hormone, 17β-estradiol, prolactin, total testosterone, dehydroepiandrosterone sulfate and allopregnanolone levels...
August 31, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28853624/prevention-of-recurrent-lower-urinary-tract-infections-in-postmenopausal-women-with-genitourinary-syndrome-outcome-after-6-months-of-treatment-with-ospemifene
#14
Michele Carlo Schiavi, Anna Di Pinto, Valentina Sciuga, Pierangelo Faiano, Chiara Di Tucci, Ottavia D'oria, Angela Martoccia, Giovanni Prata, Carlo Carraro, Rosa Ostuni, Marzio Angelo Zullo, Ludovico Muzii, Pierluigi Benedetti Panici
Aim of this study was to evaluate the efficacy of ospemifene in the prevention of recurrent lower urinary tract infections in postmenopausal women with vulvovaginal atrophy. The study have a retrospective design. Thirty-nine patients were enrolled. Patients underwent clinical examination and urine culture. The urinary symptoms and the quality of life were evaluated with UTISA score, PUF and SF-36 questionnaires before and after treatment. All 39 patients received ospemifene 60 mg one tablet/daily for 6 months...
August 30, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28850273/therapeutic-approach-for-metabolic-disorders-and-infertility-in-women-with-pcos
#15
G Morgante, M G Massaro, A Di Sabatino, V Cappelli, V De Leo
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 5-10% of women of reproductive age. It generally shows with oligo/amenorrhea, anovulatory cycles, clinical o biochemical hirsutism, polycystic ovaries and, in a significant percentage of cases, insulin resistance. PCOS is defined as a multifactorial pathology, determined by the association of many factors: genetic, endocrine and environmental. The first and most effective treatment of PCOS is to change life-style and lose weight. The use of oral contraceptives has been shown effective in reducing acne and hirsutism and regulates the menstrual cycle...
August 29, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28850271/unexpected-repeat-immature-oocyte-response-after-ivf-stimulation-a-case-report
#16
Vandana Mishra, Lakshmi Chirumamilla
The purpose of ovarian stimulation in IVF is to recover mature oocytes at metaphase II stage which are capable of fertilization either when mixed with sperm or after ICSI. However, there have been instances when even after controlled ovarian stimulation (COS) and correct administration of human chorionic gonadotrophin (hCG) trigger for final oocyte maturation, the oocytes were found to be arrested at germinal vesicle (GV) or metaphase I (MI) stage. Similar dilemma is faced in cases of empty follicle syndrome (either genuine or due to inadequate response), however, in this condition, there is no retrieval of oocytes despite presence of mature looking follicles...
August 29, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28846055/homeostatic-model-assessment-of-beta-cell-function-predicting-abnormal-oral-glucose-tolerance-testing-in-pregnancy-a-systematic-review-and-meta-analysis
#17
Jonas Ellerbrock, Jolijn M H A Bohnen, Veronica A Lopes van Balen, Eva G Mulder, Robert Aardenburg, Marc E A Spaanderman
BACKGROUND: Gestational diabetes mellitus (GDM) complicates 1-14% of pregnancies and relates to increased risk of adverse obstetric outcomes. Currently GDM is diagnosed using an oral glucose tolerance test (OGTT), which is burdensome and time intensive. OBJECTIVE: To compare current literature on whether the homeostatic model assessment beta cell function (HOMA-β) is an accurate predictor of an abnormal OGTT in pregnant women. METHODS: Pubmed, Cochrane and Embase were searched...
August 28, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28828894/correction-to-leeaunkulsathean-et%C3%A2-al-the-effect-of-different-progestogens-on-sleep-in-postmenopausal-women-a-randomized-trial
#18
(no author information available yet)
No abstract text is available yet for this article.
August 22, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28792788/age-related-decline-in-amh-is-assay-dependent-limiting-clinical-interpretation-of-repeat-amh-measures-across-the-reproductive-lifespan
#19
Lukasz Plociennik, Scott M Nelson, Aron Lukaszuk, Michal Kunicki, Agnieszka Podfigurna, Blazej Meczekalski, Krzysztof Lukaszuk
PURPOSE: The aim of the study was to determine whether the assays exhibit an interaction with age and exhibit heterogeneous age related declines in AMH. Apart of chronological age, AMH variation was investigated with relation to menstrual cycle day (MCD). The goal implicates two questions: Are distributions of AMH concentrations homogenous after adjustment for the specific AMH assay? Does age-assay product has an effect on AMH depletion? METHODS: The study was conducted by examining results of AMH tests performed for 12,917 women with four types of AMH assays: Immunotech I generation kit (IMI, 4016 samples), Beckman Coulter II generation kit RUO (BCII RUO, 3430 samples), Beckman Coulter II generation kit with IVD certificate (BCII IVD, 830 samples), and Ansh Labs I generation kit (AnshLabs, 4641 samples)...
August 9, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28762851/concentration-of-sulfated-glycosaminoglycans-in-the-mammary-tissue-of-female-rats-with-the-aging-and-about-hormonal-influence
#20
Sueli M P S Torres, Helena B Nader, Ricardo S Simões, Edmund C Baracat, Manuel de J Simões, Luiz F P Fuchs, José Maria Soares-Jr, Regina Célia T Gomes
It was to evaluate the concentration of sulfate glycosaminoglycans (GAG) in mammary tissue of the young and adult female rats and ovariectomized females rats after hormonal stimulation. For this purpose, 60 female rats were divided into six groups with 10 animals/each: nonovariectomized groups: G1 (5 months), and G2 (15 months) and ovariectomized groups: OG (vehicle); EG: (estradiol, 7 days of treatment), PG (progesterone acetate, 23 days of treatment) and EPG: (estradiol (7 days of treatment) and next progesterone acetate (23 days of treatment)...
August 1, 2017: Gynecological Endocrinology
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