journal
MENU ▼
Read by QxMD icon Read
search

BioFactors

journal
https://www.readbyqxmd.com/read/29322615/melatonin-protects-against-a%C3%AE-induced-neurotoxicity-in-primary-neurons-via-mir-132-pten-akt-foxo3a-pathway
#1
Yue Zhao, Ranran Zhao, Jintao Wu, Qian Wang, Kunkun Pang, Qingqing Shi, Qing Gao, Yanlai Hu, Xiaoguang Dong, Jing Zhang, Jinhao Sun
Alzheimer's disease (AD) is a kind of neurodegenerative disorder associated with age. Investigations suggest that amyliod-β (Aβ) is implicated in the pathogenesis of AD. The accumulation of Aβ in the brain causes oxidative stress and synaptic toxicity, leads to synaptic dysfunction and neuronal death. Previous investigations suggest that melatonin an endogenous hormone can counteract Aβ-induced neurotoxicity. However, the molecular mechanisms of Aβ-induced toxicity and melatonin treatment remain elusive...
January 11, 2018: BioFactors
https://www.readbyqxmd.com/read/29322567/oral-delivery-system-enhanced-the-bioavailability-of-stilbenes-resveratrol-and-pterostilbene
#2
REVIEW
Ru-Min Peng, Guan-Ru Lin, Yuwen Ting, Jing-Yu Hu
Stilbenes are a large group of compounds with the C6 C2 C6 skeleton, in which two aromatic rings are connected by an ethylene bridge. Resveratrol and its structural analog, pterostilbene, are by far the two most widely researched stilbenes in terms of their beneficial bioactivities. However, the bioefficacy of these compounds is greatly reduced when consumed orally due to their poor aqueous solubility, which leads to poor bioavailability. To overcome the limitation, strategies improving their solubility, absorption, and systemic concentration were applied when designing a suitable edible delivery system...
January 11, 2018: BioFactors
https://www.readbyqxmd.com/read/29315886/metabolism-and-pharmacokinetics-of-resveratrol-and-pterostilbene
#3
REVIEW
Pei Wang, Shengmin Sang
Beneficial properties of resveratrol and pterostilbene, a dimethyl ether analog of resveratrol, have attracted increasing interest in recent years. Resveratrol and pterostilbene exhibit many pharmacological similarities and both of them are generally considered to be safe for human consumption. Beyond the structural and general bioactivity similarities between them, large amounts of data are now available to reveal the metabolic fate and pharmacological differences between them. Pterostilbene was found to be more metabolically stable and usually exhibited stronger pharmacological activities than that of resveratrol...
January 8, 2018: BioFactors
https://www.readbyqxmd.com/read/29315906/antiobesity-molecular-mechanisms-of-action-resveratrol-and-pterostilbene
#4
REVIEW
Min-Hsiung Pan, Jia-Ching Wu, Chi-Tang Ho, Ching-Shu Lai
Obesity is a current global epidemic that has led to a marked increase in metabolic diseases. However, its treatment remains a challenge. Obesity is a multifactorial disease, which involves the dysfunction of neuropeptides, hormones, and inflammatory adipokines from the brain, gut, and adipose tissue. An understanding of the mechanisms and signal interactions in the crosstalk between organs and tissue in the coordination of whole-body energy metabolism would be helpful to provide therapeutic and putative approaches to the treatment and prevention of obesity and related complications...
January 5, 2018: BioFactors
https://www.readbyqxmd.com/read/29265673/presynaptic-glp-1-receptors-enhance-the-depolarization-evoked-release-of-glutamate-and-gaba-in-the-mouse-cortex-and-hippocampus
#5
Claudia Rebosio, Matilde Balbi, Mario Passalacqua, Roberta Ricciarelli, Ernesto Fedele
Glucagon-like peptide-1 receptors (GLP-1Rs) have been shown to mediate cognitive-enhancing and neuroprotective effects in the central nervous system. However, little is known about their physiological roles on central neurotransmission, especially at the presynaptic level. Using purified synaptosomal preparations and immunofluorescence techniques, here we show for the first time that GLP-1Rs are localized on mouse cortical and hippocampal synaptic boutons, in particular on glutamatergic and GABAergic nerve terminals...
December 19, 2017: BioFactors
https://www.readbyqxmd.com/read/29220106/chemoprevention-by-resveratrol-and-pterostilbene-targeting-on-epigenetic-regulation
#6
REVIEW
Pei-Sheng Lee, Yi-Shiou Chiou, Chi-Tang Ho, Min-Hsiung Pan
Epigenetic mechanisms are essential in regulating normal cellular functions and play an important role during the disease developmental stages. However, aberrant epigenetic mechanisms may lead to pathological consequences such as cancer, neurological disorders, bone and skeletal diseases, cardiovascular dysfunction, and metabolic syndrome. The molecular mechanisms of epigenetic modification include DNA methylation, histone modification (acetylation, methylation and phosphorylation), and microRNAs (miRNAs). Unlike genetic modifications, epigenetic states of genes are reversible and can be altered by certain intrinsic and extrinsic factors...
December 8, 2017: BioFactors
https://www.readbyqxmd.com/read/29220105/less-fibrosis-in-elderly-subjects-supplemented-with-selenium-and-coenzyme-q10-a-mechanism-behind-reduced-cardiovascular-mortality
#7
Urban Alehagen, Jan Aaseth, Jan Alexander, Erland Svensson, Peter Johansson, Anders Larsson
BACKGROUND: In an intervention study where 221 healthy elderly persons received selenium and coenzyme Q10 as a dietary supplement, and 222 received placebo for 4 years we observed improved cardiac function and reduced cardiovascular mortality. As fibrosis is central in the aging process, we investigated the effect of the intervention on biomarkers of fibrogenic activity in a subanalysis of this intervention study. MATERIAL AND METHODS: In the present subanalysis 122 actively treated individuals and 101 controls, the effect of the treatment on eight biomarkers of fibrogenic activity were assessed...
December 8, 2017: BioFactors
https://www.readbyqxmd.com/read/29210129/effect-of-resveratrol-and-pterostilbene-on-aging-and-longevity
#8
REVIEW
Yi-Rong Li, Shiming Li, Chi-Chien Lin
Over the past years, several studies have found that foods rich in polyphenols protect against age-related disease, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension and Alzheimer's disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as anti-aging compounds through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence...
December 6, 2017: BioFactors
https://www.readbyqxmd.com/read/29205560/targeting-cancer-stem-cells-and-signaling-pathways-by-resveratrol-and-pterostilbene
#9
REVIEW
Lingling Zhang, Xiang Wen, Mengmeng Li, Shiming Li, Hui Zhao
In past decades, increasing evidence regarding cancer stem cells (CSCs) may account for carcinogenesis, tumor drug-resistant, and metastasis. CSCs are even considered as the root causes of tumor recurrence and metastases. Targeting CSCs may provide a new clue to cure cancer. Epidemiological and clinical studies have suggested that intake of dietary natural products may bring health benefits including lowering risk of cancer incidence. In this review, we have particularly focused on targeting signaling pathways of CSCs by natural resveratrol and its dimethylated derivative pterostilbene...
December 4, 2017: BioFactors
https://www.readbyqxmd.com/read/29193391/dihydromyricetin-inhibits-nlrp3-inflammasome-dependent-pyroptosis-by-activating-the-nrf2-signaling-pathway-in-vascular-endothelial-cells
#10
Qin Hu, Ting Zhang, Long Yi, Xi Zhou, Mantian Mi
Increasing evidence demonstrates that pyroptosis, pro-inflammatory programmed cell death, is linked to atherosclerosis; however, the underlying mechanisms remain to be elucidated. Dihydromyricetin (DHM), a natural flavonoid, was reported to exert anti-oxidative and anti-inflammatory bioactivities. However, the effect of DHM on atherosclerosis-related pyroptosis has not been studied. In the present study, palmitic acid (PA) treatment led to pyroptosis in human umbilical vein endothelial cells (HUVECs), as evidenced by caspase-1 activation, LDH release, and propidium iodide-positive staining; enhanced the maturation and release of proinflammatory cytokine IL-1β and activation of the NLRP3 inflammasome; and markedly increased intracellular reactive oxygen species (ROS) and mitochondrial ROS (mtROS) levels...
November 29, 2017: BioFactors
https://www.readbyqxmd.com/read/29193444/morin-exerts-neuroprotection-via-attenuation-of-ros-induced-oxidative-damage-and-neuroinflammation-in-experimental-diabetic-neuropathy
#11
Pragna Bachewal, Chayanika Gundu, Veera Ganesh Yerra, Anil Kumar Kalvala, Aparna Areti, Ashutosh Kumar
Morin, a bioflavonoid with diverse pharmacological effects against various diseases; in most cases morin protective effects were attributed to its detoxifying effect against reactive oxygen species (ROS). Diabetic neuropathy (DN) is a chronic, debilitating neuronal pain associated with intense generation of free radicals and proinflammatory cytokine accumulation in peripheral neurons. We investigated the pharmacological effect of morin against metabolic excess mediated mitochondrial ROS generation and corresponding effect on Nrf2, NF-κB pathways in Streptozotocin (STZ)-induced diabetic rats and in high glucose insulted Mouse neuroblastoma cell line, Neuro 2A (N2A)...
November 28, 2017: BioFactors
https://www.readbyqxmd.com/read/29193412/role-of-resveratrol-in-regulation-of-cellular-defense-systems-against-oxidative-stress
#12
REVIEW
Van-Long Truong, Mira Jun, Woo-Sik Jeong
Resveratrol, a natural polyphenolic compound, is found in various kinds of fruits, plants, and their commercial products such as red wine. It has been demonstrated to exhibit a variety of health-promoting effects including prevention and/or treatment of cardiovascular diseases, inflammation, diabetes, neurodegeneration, aging, and cancer. Cellular defensive properties of resveratrol can be explained through its ability of either directly neutralizing reactive oxygen species/reactive nitrogen species (ROS/RNS) or indirectly upregulating the expression of cellular defensive genes...
November 28, 2017: BioFactors
https://www.readbyqxmd.com/read/29168580/resveratrol-pterostilbene-and-dementia
#13
REVIEW
Klaus W Lange, Shiming Li
Resveratrol is a natural phytoestrogen with neuroprotective properties. Polyphenolic compounds including resveratrol exert in vitro antioxidant, anti-inflammatory, and antiamyloid effects. Resveratrol and its derivative pterostilbene are able to cross the blood-brain barrier and to influence brain activity. The present short review summarizes the available evidence regarding the effects of these polyphenols on pathology and cognition in animal models and human subjects with dementia. Numerous investigations in cellular and mammalian models have associated resveratrol and pterostilbene with protection against dementia syndromes such as Alzheimer's disease (AD) and vascular dementia...
November 23, 2017: BioFactors
https://www.readbyqxmd.com/read/29064586/a-pivotal-role-of-ampk-signaling-in-medicarpin-mediated-formation-of-brown-and-beige-adipocytes-from-c3h10t1-2-mesenchymal-stem-cells
#14
Khan Mohammad Imran, Dahyeon Yoon, Yong-Sik Kim
Obesity poses a substantial threat of a worldwide epidemic and requires better understanding of adipose-tissue biology as well as necessitates research into the etiology and therapeutic interventions. In this study, Medicarpin (Med), a natural pterocarpan, was selected (by screening) as a small-molecule inducer of adipocyte differentiation among 854 candidates by using C3H10T1/2 mesenchymal stem cell; a cellular model of adipogenesis. Med induced the expression of brown-adipocyte commitment marker Bmp7 as well as the early regulators of brown fat fate Pparγ, Prdm16, and Pgc-1α during differentiation of C3H10T1/2 mesenchymal stem cells...
October 24, 2017: BioFactors
https://www.readbyqxmd.com/read/29048780/magnesium-isoglycyrrhizinate-promotes-the-activated-hepatic-stellate-cells-apoptosis-via-endoplasmic-reticulum-stress-and-ameliorates-fibrogenesis-in-vitro-and-in-vivo
#15
Mianli Bian, Xingran Chen, Chenxi Zhang, Huanhuan Jin, Feixia Wang, Jiangjuan Shao, Anping Chen, Feng Zhang, Shizhong Zheng
Varied pathogenetic elements have been touched upon the liver fibrosis, including inflammatory, stress, apoptosis and unfolded proteins aggregation. Magnesium Isoglycyrrhizinate (MgIG) has been accepted to be a neuroprotective effect, hepatoprotective and anti-inflammatory molecule. In our vitro researches, MgIG was considered to activate hepatic stellate cells (HSCs) apoptosis by promoting endoplasmic reticulum stress (ERS) detrimental response to a certain extent. Consequently, MgIG showed its potential therapeutic capacity in fibrogenesis and counteracted the pathogenetic aspects, which were involved in integrating current treatments correcting liver fibrosis...
October 19, 2017: BioFactors
https://www.readbyqxmd.com/read/29048765/ageratum-conyzoides-l-inhibits-5-alpha-reductase-gene-expression-in-human-prostate-cells-and-reduces-symptoms-of-benign-prostatic-hypertrophy-in-otherwise-healthy-men-in-a-double-blind-randomized-placebo-controlled-clinical-study
#16
Matthew Detering, Elizabeth Steels, Sundar Rao Koyyalamudi, Elena Allifranchini, Elena Bocchietto, Luis Vitetta
A double-blind, randomized, placebo-controlled clinical trial assessed the efficacy and safety of Ageratum conyzoides in treating benign prostatic hypertrophy (BPH). In this study, 109 men with medically diagnosed BPH, aged 41-76 years, were administered the investigational product, A. conyzoides extract at a dose of 250 mg/d or placebo, q.d. for 12 weeks. The primary outcome measures were the International Prostate Symptom Score (IPSS), daily urinary frequency and safety evaluations. The secondary outcome measures were testosterone, dihydrotestosterone, oestradiol, sex hormone binding globulin (SHBG), Dehydroepiandrosterone sulfate (DHEA-S) and cortisol levels, and prostate specific antigen (PSA), lipids, blood glucose, the Aging Male's Symptom (AMS) Score and sexual function assessed by Derogatis Interview for Sexual Functioning-Self Report (DISF-SR)...
October 19, 2017: BioFactors
https://www.readbyqxmd.com/read/28922499/antioxidants-wonder-drugs-or-quackery
#17
REVIEW
Angelo Azzi
An answer to the question posed by the title must be simple not to disturb in his tomb Albert Einstein, who wrote "Man muß die Dinge so einfach wie möglich machen. Aber nicht einfacher". A simple answer (not simpler) can be: Antioxidants are not antioxidants, they are not wonder drugs and they are not all quackery; but they are not nothing. The arguments in support of this conundrumic statement will be developed below. © 2017 BioFactors, 2017.
September 18, 2017: BioFactors
https://www.readbyqxmd.com/read/28984393/in-memory-of-tommaso-galeotti
#18
Angelo Azzi
No abstract text is available yet for this article.
September 10, 2017: BioFactors
https://www.readbyqxmd.com/read/28759135/acute-and-long-term-administration-of-palmitoylcarnitine-induces-muscle-specific-insulin-resistance-in-mice
#19
Edgars Liepinsh, Marina Makrecka-Kuka, Elina Makarova, Kristine Volska, Karlis Vilks, Eduards Sevostjanovs, Unigunde Antone, Janis Kuka, Reinis Vilskersts, Daina Lola, Einars Loza, Solveiga Grinberga, Maija Dambrova
Acylcarnitine accumulation has been linked to perturbations in energy metabolism pathways. In this study, we demonstrate that long-chain (LC) acylcarnitines are active metabolites involved in the regulation of glucose metabolism in vivo. Single-dose administration of palmitoylcarnitine (PC) in fed mice induced marked insulin insensitivity, decreased glucose uptake in muscles, and elevated blood glucose levels. Increase in the content of LC acylcarnitine induced insulin resistance by impairing Akt phosphorylation at Ser473...
September 10, 2017: BioFactors
https://www.readbyqxmd.com/read/28753257/caffeic-acid-attenuates-the-inflammatory-stress-induced-by-glycated-ldl-in-human-endothelial-cells-by-mechanisms-involving-inhibition-of-age-receptor-oxidative-and-endoplasmic-reticulum-stress
#20
Laura Toma, Gabriela M Sanda, Loredan S Niculescu, Mariana Deleanu, Camelia S Stancu, Anca V Sima
Type 2 diabetes mellitus is a worldwide epidemic and its atherosclerotic complications determine the high morbidity and mortality of diabetic patients. Caffeic acid (CAF), a phenolic acid present in normal diets, is known for its antioxidant properties. The aim of this study was to investigate CAF's anti-inflammatory properties and its mechanism of action, using cultured human endothelial cells (HEC) incubated with glycated low-density lipoproteins (gLDL). Levels of the receptor for advanced glycation end-products (RAGE), inflammatory stress markers (C reactive protein, CRP; vascular cell adhesion molecule-1, VCAM-1; monocyte chemoattractant protein-1, MCP-1), and oxidative stress and endoplasmic reticulum stress (ERS) markers were evaluated in gLDL-exposed HEC, in the presence/absence of CAF...
September 10, 2017: BioFactors
journal
journal
29880
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"