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BioFactors

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https://www.readbyqxmd.com/read/27896891/stat3-targeting-by-polyphenols-novel-therapeutic-strategy-for-melanoma
#1
REVIEW
Saeideh Momtaz, Kamal Niaz, Faheem Maqbool, Mohammad Abdollahi, Luca Rastrelli, Seyed Mohammad Nabavi
Melanoma or malignant melanocytes appear with the low incidence rate, but very high mortality rate worldwide. Epidemiological studies suggest that polyphenolic compounds contribute for prevention or treatment of several cancers particularly melanoma. Such findings motivate to dig out novel therapeutic strategies against melanoma, including research toward the development of new chemotherapeutic and biologic agents that can target the tumor cells by different mechanisms. Recently, it has been found that signal transducer and activator of transcription 3 (STAT3) is activated in many cancer cases surprisingly...
November 29, 2016: BioFactors
https://www.readbyqxmd.com/read/27896883/curcumin-as-a-multifaceted-compound-against-human-papilloma-virus-infection-and-cervical-cancers-a-review-of-chemistry-cellular-molecular-and-preclinical-features
#2
REVIEW
Manouchehr Teymouri, Matteo Pirro, Thomas P Johnston, Amirhosein Sahebkar
Curcumin, the bioactive polyphenolic ingredient of turmeric, has been extensively studied for its effects on human papilloma virus (HPV) infection as well as primary and malignant squamous cervical cancers. HPV infections, especially those related to HPV 16 and 18 types, have been established as the leading cause of cervical cancer; however, there are also additional contributory factors involved in the etiopathogenesis of cervical cancers. Curcumin has emerged as having promising chemopreventive and anticancer effects against both HPV-related and nonrelated cervical cancers...
November 29, 2016: BioFactors
https://www.readbyqxmd.com/read/27862460/intracellular-cysteine-oxidation-is-modulated-by-aquaporin-8-mediated-hydrogen-peroxide-channeling-in-leukaemia-cells
#3
Francesco Vieceli Dalla Sega, Cecilia Prata, Laura Zambonin, Cristina Angeloni, Benedetta Rizzo, Silvana Hrelia, Diana Fiorentini
The modulation of H2 O2 production by NADPH oxidase (Nox), on vascular endothelial growth factor (VEGF) stimulation, affects the redox signaling linked to cancer cell proliferation. H2 O2 signal transduction involves reversible oxidation of thiol proteins, leading to the formation of cysteine sulfenic acids, responsible for the temporary inactivation of many phosphatases. These events imply that H2 O2 reaches its intracellular targets. As Aquaporin-8 (AQP8) has been demonstrated to funnel Nox-produced H2 O2 across the plasma membrane, this study aims to elucidate the role of AQP8 in the redox signaling occurring in human leukaemia B1647 cells that constitutively produce VEGF...
November 15, 2016: BioFactors
https://www.readbyqxmd.com/read/27862450/arachidonic-acid-and-lipoxin-a4-attenuate-alloxan-induced-cytotoxicity-to-rin5f-cells-in-vitro-and-type-1-diabetes-mellitus-in-vivo
#4
Naveen K V Gundala, Vegi G M Naidu, Undurti N Das
OBJECTIVE: We studied whether polyunsaturated fatty acids (PUFAs) can protect rat insulinoma (RIN5F) cells against alloxan-induced apoptosis in vitro and type 1 diabetes mellitus (type 1 DM) in vivo and if so, mechanism of this beneficial action. MATERIAL AND METHODS: In vitro study was conducted using RIN5F cells while in vivo study was performed in Wistar rats. The effect of PUFAs, cyclo-oxygenase and lipoxygenase inhibitors, various eicosanoids and PUFAs metabolites: lipoxin A4 (LXA4), resolvin D2 and protectin against alloxan-induced cytotoxicity to RIN5F cells and type 1 DM was studied...
November 15, 2016: BioFactors
https://www.readbyqxmd.com/read/27859738/serum-albumin-as-a-local-therapeutic-agent-in-cell-therapy-and-tissue-engineering
#5
REVIEW
Dénes B Horváthy, Melinda Simon, Charlotte M Schwarz, Mariana Masteling, Gabriella Vácz, István Hornyák, Zsombor Lacza
Albumin is a major plasma protein that has become ubiquitous in regenerative medicine research. As such, many studies have examined its structure and advantageous properties. However, a systematic and comprehensive understanding of albumin's role, capabilities and therapeutic potential still eludes the field. In the present work, we review how albumin is applied in tissue engineering, including cell culture and storage, in vitro fertilization and transplantation. Furthermore, we discuss how albumin's physiological role extends beyond a carrier for metal ions, fatty acids, pharmacons and growth factors...
November 11, 2016: BioFactors
https://www.readbyqxmd.com/read/27801960/inhibition-of-the-sphk1-s1p-signaling-pathway-by-melatonin-in-mice-with-liver-fibrosis-and-human-hepatic-stellate-cells
#6
Bárbara González-Fernández, Diana I Sánchez, Irene Crespo, Beatriz San-Miguel, Marcelino Álvarez, María J Tuñón, Javier González-Gallego
The sphingosine kinase 1/sphingosine 1-phosphate (SphK1/S1P) system is involved in different pathological processes, including fibrogenesis. Melatonin abrogates activation of hepatic stellate cells (HSCs) and attenuates different profibrogenic pathways in animal models of fibrosis, but it is unknown if protection associates with its inhibitory effect on the SphK1/S1P axis. Mice in treatment groups received carbon tetrachloride (CCl4 ) 5 μL g(-1) body wt i.p. twice a week for 4 or 6 weeks. Melatonin was given at 5 or 10 mg kg(-1)  day(-1) i...
November 1, 2016: BioFactors
https://www.readbyqxmd.com/read/27801955/curcumin-prevents-mitochondrial-dynamics-disturbances-in-early-5-6-nephrectomy-relation-to-oxidative-stress-and-mitochondrial-bioenergetics
#7
Omar Emiliano Aparicio-Trejo, Edilia Tapia, Eduardo Molina-Jijón, Omar Noel Medina-Campos, Norma Angélica Macías-Ruvalcaba, Juan Carlos León-Contreras, Rogelio Hernández-Pando, Fernando E García-Arroyo, Magdalena Cristóbal, Laura Gabriela Sánchez-Lozada, José Pedraza-Chaverri
Five-sixths nephrectomy (5/6NX) is a widely used model to study the mechanisms leading to renal damage in chronic kidney disease (CKD). However, early alterations on renal function, mitochondrial dynamics, and oxidative stress have not been explored yet. Curcumin is an antioxidant that has shown nephroprotection in 5/6NX-induced renal damage. The aim of this study was to explore the effect of curcumin on early mitochondrial alterations induced by 5/6NX in rats. In isolated mitochondria, 5/6NX-induced hydrogen peroxide production was associated with decreased activity of complexes I and V, decreased activity of antioxidant enzymes, alterations in oxygen consumption and increased MDA-protein adducts...
November 1, 2016: BioFactors
https://www.readbyqxmd.com/read/27801948/cooperation-between-the-bacterial-derived-short-chain-fatty-acid-butyrate-and-interleukin-22-detected-in-human-caco2-colon-epithelial-carcinoma-cells
#8
Malte Bachmann, Carlotta Meissner, Josef Pfeilschifter, Heiko Mühl
By generating biologically active factors luminal microbiota shape the intestinal micro-milieu thereby regulating pathological processes such as inflammation and carcinogenesis. Preclinical data suggest that bacterial-derived butyrate and the signal transducer and activator of transcription (STAT)-3 activating cytokine interleukin (IL)-22 display concordant protective properties at the inflamed colonic epithelium. Herein, biochemical cooperation between the short-chain fatty acid butyrate and IL-22 was investigated by focusing on human Caco2 colon epithelial/carcinoma cells...
November 1, 2016: BioFactors
https://www.readbyqxmd.com/read/27671897/blebbishields-and-mitotic-cells-exhibit-robust-macropinocytosis
#9
Goodwin G Jinesh, Ashish M Kamat
Cancer stem cells can survive and undergo transformation after apoptosis by initiating robust endocytosis. Endocytosis in-turn drives formation of serpentine filopodia, which promote construction of blebbishields from apoptotic bodies. However, the status and role of macropinocytosis in blebbishields is not known. Here, we show by scanning electron microscopy and by macropinocytosis assays that blebbishields exhibit robust macropinocytosis. Inhibiting dynamin-mediated endocytosis does not affect macropinocytosis in blebbishields or in mitotic cells...
September 27, 2016: BioFactors
https://www.readbyqxmd.com/read/27663177/effect-of-mahanimbine-an-alkaloid-from-curry-leaves-on-high-fat-diet-induced-adiposity-insulin-resistance-and-inflammatory-alterations
#10
Sneha Jagtap, Pragyanshu Khare, Priyanka Mangal, Kanthi Kiran Kondepudi, Mahendra Bishnoi, Kamlesh Kumar Bhutani
Spices and condiments, small but an integral part of the daily diet, are known to affect physiological functions. This study evaluated the effects of mahanimbine, a major carbazole alkaloid from Murraya koenigii (curry leaves), against progression of high-fat diet (HFD)-induced metabolic complications in mice (male and female). Mahanimbine at 2 mg/kg (HFD + LD) and 4 mg/kg (HFD + HD) of body weight was administered daily along with HFD feeding for 12 weeks. At the end of the study, male HFD + LD and HFD + HD groups showed 51...
September 24, 2016: BioFactors
https://www.readbyqxmd.com/read/27662823/comparative-effects-of-torasemide-and-furosemide-on-gap-junction-proteins-and-cardiac-fibrosis-in-a-rat-model-of-dilated-cardiomyopathy
#11
Kenichi Watanabe, Remya Sreedhar, Rajarajan A Thandavarayan, Vengadeshprabhu Karuppagounder, Vijayasree V Giridharan, Shanish Antony, Meilei Harima, Masahiko Nakamura, Kenji Suzuki, Hiroshi Suzuki, Hirohito Sone, Somasundaram Arumugam
Cardiac fibrosis is the major hallmark of adverse cardiac remodeling in chronic heart failure (CHF) and its therapeutic targeting might help against cardiac dysfunction during chronic conditions. Diuretic agents are potentially useful in these cases, but their effects on the cardiac fibrosis pathogenesis are yet to be identified. This study was designed to identify and compare the effects of diuretic drugs torasemide and furosemide on cardiac fibrosis in a rat model of dilated cardiomyopathy induced by porcine cardiac myosin mediated experimental autoimmune myocarditis...
September 24, 2016: BioFactors
https://www.readbyqxmd.com/read/27658353/mangiferin-a-review-of-sources-and-interventions-for-biological-activities
#12
Jyotshna, Puja Khare, Karuna Shanker
Xanthones are naturally synthesized in various biological systems such as plants, lichens, and fungi and are stored as by-products. In addition to taxonomic significance they are also important in the treatment/management of a number of human disorders. Mangiferin and its derived lead molecule have never qualified for use in a clinical trial despite a number of pharmacological studies that have proven its effectiveness as an antioxidant, analgesic, antidiabetic, antiproliferative, chemopreventive, radioprotective, cardiotonic, immunomodulatory, and diuretic...
September 23, 2016: BioFactors
https://www.readbyqxmd.com/read/27628030/deoxyelephantopin-induces-apoptosis-in-hepg2-cells-via-oxidative-stress-nf-%C3%AE%C2%BAb-inhibition-and-mitochondrial-dysfunction
#13
Tahir Mehmood, Amara Maryam, He Zhang, Yongming Li, Muhammad Khan, Tonghui Ma
Deoxyelephantopin (DET), a naturally occurring sesquiterpene lactone present in Chinese medicinal herb, Elephantopus scaber has been shown to exert anti-inflammatory as well as anticancer effects in various cancer cells of human origin in vitro. However, the exact molecular mechanism underlying DET-induced apoptosis remains largely unexplored, particularly in human hepatocellular carcinoma G2 (HepG2) cells. In the present study, we found that DET inhibits proliferation and induces apoptosis in HepG2 cells in a dose-dependent manner...
September 15, 2016: BioFactors
https://www.readbyqxmd.com/read/27619846/mir-346-and-mir-582-3p-regulated-eg-vegf-expression-and-trophoblast-invasion-via-matrix-metalloproteinases-2-and-9
#14
Mei-Tsz Su, Pei-Yin Tsai, Hui-Ling Tsai, Yi-Chi Chen, Pao-Lin Kuo
Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is an important regulator for embryo implantation and placental development, and is clinically associated with several obstetric disorders related to insufficient or inappropriate trophoblast invasion, such as recurrent abortion, preeclampsia, and intrauterine fetal growth restriction. This study was performed to identify the microRNAs targeting EG-VEGF, and evaluate the regulatory effect on trophoblast biology. miR-346 and miR-582-3p were initially identified via bioinformatic tools, and their specific binding sites on the EG-VEGF 3'UTR were further confirmed using dual luciferase and a co-transfection assays...
September 13, 2016: BioFactors
https://www.readbyqxmd.com/read/27774668/bio-and-chemical-syntheses-of-mangiferin-and-congeners
#15
Teddy Stephen Ehianeta, Stéphane Laval, Biao Yu
Mangiferin (2C-β-d-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone) is a xanthone C-glycoside occurring in many plant species. Composed of a glucose unit C1→2 linked to a 1,3,6,7-tetrahydroxyxanthone aglycone, mangiferin exhibits a wide range of biological activities, which recently renewed its interest as a potential pharmacophore. Mangiferin is mainly isolated after extraction procedures from natural sources alongside with its isoforms isomangiferin, homomangiferin, and neomangiferin. However, enzymatic and chemical approaches have been developed to access these phytochemicals, which address the challenging construction of the C-glycosidic linkage...
September 10, 2016: BioFactors
https://www.readbyqxmd.com/read/27534809/mangiferin-modulation-of-metabolism-and-metabolic-syndrome
#16
REVIEW
Ekaterina Vladimirovna Fomenko, Yuling Chi
The recent emergence of a worldwide epidemic of metabolic disorders, such as obesity and diabetes, demands effective strategy to develop nutraceuticals or pharmaceuticals to halt this trend. Natural products have long been and continue to be an attractive source of nutritional and pharmacological therapeutics. One such natural product is mangiferin (MGF), the predominant constituent of extracts of the mango plant Mangifera indica L. Reports on biological and pharmacological effects of MGF increased exponentially in recent years...
September 10, 2016: BioFactors
https://www.readbyqxmd.com/read/27591048/differential-inhibition-of-human-erythrocyte-acetylcholinesterase-by-polyphenols-epigallocatechin-3-gallate-and-resveratrol-relevance-of-the-membrane-bound-form
#17
Paula B Salazar, Alejandro de Athayde Moncorvo Collado, Verónica Canal-Martínez, Carlos J Minahk
The activity of acetylcholinesterase (AChE) from human erythrocytes was tested in the presence of the phenolic compounds resveratrol and epigallocatechin-3-gallate (EGCG). Even though the stilbene barely changed this enzymatic activity, EGCG did inhibit AChE. Importantly, it preferentially acted on the membrane-bound enzyme rather than on its soluble form. Actually, it was shown that this flavonoid may bind to the red blood cell membrane surface, which may improve the interaction between EGCG and AChE. Therefore, caution should be taken when screening AChE inhibitors...
September 3, 2016: BioFactors
https://www.readbyqxmd.com/read/27580701/nutrigenomics-of-extra-virgin-olive-oil-a-review
#18
Marta Piroddi, Adriana Albini, Roberto Fabiani, Lisa Giovannelli, Cristina Luceri, Fausta Natella, Patrizia Rosignoli, Teresa Rossi, Agnese Taticchi, Maurizio Servili, Francesco Galli
Nutrigenomics data on the functional components of olive oil are still sparse, but rapidly increasing. Olive oil is the main source of fat and health-promoting component of the Mediterranean diet. Positive effects have been observed on genes involved in the pathobiology of most prevalent age- and lifestyle-related human conditions, such as cancer, cardiovascular disease and neurodegeneration. Other effects on health-promoting genes have been identified for bioactive components of olives and olive leafs. Omics technologies are offering unique opportunities to identify nutritional and health biomarkers associated with these gene responses, the use of which in personalized and even predictive protocols of investigation, is a main breakthrough in modern medicine and nutrition...
September 1, 2016: BioFactors
https://www.readbyqxmd.com/read/27580587/cardamonin-a-chalcone-inhibits-human-triple-negative-breast-cancer-cell-invasiveness-by-downregulation-of-wnt-%C3%AE-catenin-signaling-cascades-and-reversal-of-epithelial-mesenchymal-transition
#19
Shweta Shrivastava, Manish Kumar Jeengar, Dinesh Thummuri, Alexey Koval, Vladimir L Katanaev, Srujan Marepally, Naidu V G M
Cardamonin (CD), an active chalconoid, has shown potent anticancer effects in preclinical studies; however, the effect and underlying mechanism of CD for the treatment of triple negative breast cancer (TNBC) is unclear. This study aims to examine the cytotoxic effects of CD and investigate the underlying mechanism in human TNBC cells. The results show that CD exhibits cytotoxicity by inducing apoptosis and cell cycle arrest in TNBC cells via modulation of Bcl-2, Bax, cyt-C, cleaved caspase-3, and PARP. We find that CD significantly increases expression of the epithelial marker E-cadherin, while reciprocally decreasing expression of mesenchymal markers such as snail, slug, and vimentin in BT-549 cells...
September 1, 2016: BioFactors
https://www.readbyqxmd.com/read/27548886/the-effect-of-dietary-intake-of-coenzyme-q10-on-skin-parameters-and-condition-results-of-a-randomised-placebo-controlled-double-blind-study
#20
Katja Žmitek, Tina Pogačnik, Liljana Mervic, Janko Žmitek, Igor Pravst
Coenzyme Q10 (CoQ10) is a natural constituent of foods and is also often used in both functional foods and supplements. In addition, it is a common ingredient of cosmetics where it is believed to reduce the signs of skin ageing. However, the existing data about the effect of dietary intake of CoQ10 on skin parameters and condition are scarce. To gain an insight into this issue, we conducted a double-blind, placebo-controlled experiment with 33 healthy subjects. Our objective was to investigate the effects of 12 weeks of daily supplementation with 50 and 150 mg of CoQ10 on skin parameters and condition...
August 22, 2016: BioFactors
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