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BioFactors

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https://www.readbyqxmd.com/read/28613019/a-mystery-of-a-cup-of-coffee-an-insight-look-by-chemist
#1
REVIEW
Joanna Karpinska, Renata Świsłocka, Włodzimierz Lewandowski
Fruits, vegetables as well as processed food products of plant origin are a rich source of beneficial for human health constituents. Among them the polyphenols constitute a large group of compounds. The presented literature survey is devoted to chlorogenic acid the most abundant representative of cinnamate acids esters. Its chemical as well as biological properties are described. © 2017 BioFactors, 2017.
June 14, 2017: BioFactors
https://www.readbyqxmd.com/read/28612982/anticancer-effects-of-oleuropein
#2
REVIEW
Hesham Shamshoum, Filip Vlavcheski, Evangelia Tsiani
Cancer cells exhibit enhanced proliferation rate and a resistance to apoptosis. Epidemiological studies suggest that olive oil intake is associated with a reduced risk of cancer. Olive oil, olives, and olive leaves contain many polyphenols, including oleuropein. Recently, several studies have demonstrated that oleuropein inhibits proliferation and induces apoptosis in different cancer cell lines. In addition, anticancer effects of oleuropein have been seen in animal studies. These effects are associated with oleuropein's ability to modulate gene expression and activity of a variety of different signaling proteins that play a role in proliferation and apoptosis...
June 14, 2017: BioFactors
https://www.readbyqxmd.com/read/28608644/ezrin-as-a-possible-diagnostic-and-or-prognostic-biomarker-in-mice-lymphatic-metastatic-hepatocellular-carcinoma-in-vivo
#3
Ahmed Musa Hago Bakheet, Salma Abdi Mahmoud, Yuhong Huang, Jun Zhang, Jingwen Wang, Yuanyi Wei, Yaser Gamallat, Annoor Awadasseid, Lawrence Owusu, Yousra Khidir, Li Wang, Shuting Zhou, Pawan Kumar Seewooruttun, Boyi Xin, Wei Xuan, Zhen Su, Jianwu Tang
Hepatocellular carcinoma (HCC) ranks in the top of cancers leading to death. Early diagnosis is the big challenge in the case of HCC. Our in vitro study showed that Ezrin expression in lymphatic metastasis hepatocellular carcinoma (LNM-HCC) was associated with the metastatic rate. Here we aim to evaluate Ezrin expression as diagnostic and/or prognostic biomarker of LNM-HCC in mice. Chinese inbred 615 mice, Hca-F and Hca-P cell lines were used in the study. Histological changes were determined by Hematoxylin and Eosin, while Ezrin expression was assessed by qRT-PCR, western blot, immunohistochemistry, and enzyme-linked immunosorbent assay...
June 13, 2017: BioFactors
https://www.readbyqxmd.com/read/28608594/melatonin-ameliorates-anxiety-and-depression-like-behaviors-and-modulates-proteomic-changes-in-triple-transgenic-mice-of-alzheimer-s-disease
#4
Lulin Nie, Gang Wei, Shengming Peng, Zhongsen Qu, Ying Yang, Qian Yang, Xinfeng Huang, Jianjun Liu, Zhixiong Zhuang, Xifei Yang
Alzheimer's disease (AD) is a devastating neurodegenerative disease accompanied by neuropsychiatric symptoms, such as anxiety and depression. The levels of melatonin decrease in brains of AD patients. The potential effect of melatonin on anxiety and depression behaviors in AD and the underlying mechanisms remain unclear. In this study, we treated 10-month-old triple transgenic mice of AD (3xTg-AD) with melatonin (10 mg/kg body weight/day) for 1 month and explored the effects of melatonin on anxiety and depression-like behaviors in 3xTg-AD mice and the protein expression of hippocampal tissues...
June 13, 2017: BioFactors
https://www.readbyqxmd.com/read/28543688/glycated-human-albumin-alters-mitochondrial-respiration-in-preadipocyte-3t3-l1-cells
#5
Pascal Baret, Fanny Le Sage, Cynthia Planesse, Olivier Meilhac, Anne Devin, Emmanuel Bourdon, Philippe Rondeau
Diabetes and obesity are strongly associated with increased levels of circulating advanced glycation end products (AGEs) and reactive oxygen species (ROS). These two molecular phenomena affect the physiology of adipose tissue, a biological driver of the metabolic syndrome, leading to an inflammatory profile and insulin resistance, which could contribute to obesity/diabetes-associated complications, such as cardiovascular diseases. Herein, we investigated the impact of AGEs on mitochondrial bioenergetics in murine preadipocyte cells (3T3-L1) and cellular redox homeostasis...
May 22, 2017: BioFactors
https://www.readbyqxmd.com/read/28509396/anti-inflammatory-antioxidant-and-immunomodulatory-effects-of-curcumin-in-ovalbumin-sensitized-rat
#6
Farzaneh Shakeri, Mohammad Hossein Boskabady
BACKGROUND: Anti-inflammatory and antioxidant properties of curcumin have been shown. In this study, anti-inflammatory, antioxidant, and immunomodulatory effects of curcumin in sensitized rat were evaluated. METHODS: Six groups of rats including control (C), ovalbumin-sensitized (as a rat model of asthma, S), S groups treated with curcumin (Cu 0.15, 0.30, and 0.60 mg/mL), and 1.25 μg/mL dexamethasone (S + D) were studied. Curcumin and dexamethasone were given in animals' drinking water during sensitization period...
May 16, 2017: BioFactors
https://www.readbyqxmd.com/read/28504479/contribution-of-anthocyanin-rich-foods-in-obesity-control-through-gut-microbiota-interactions
#7
REVIEW
Giovana Jamar, Débora Estadella, Luciana Pellegrini Pisani
Obesity is characterized by low-grade inflammation and a number of metabolic disorders. Distal gut microbes' content (microbiota) is not yet fully understood but evidence shows that it is influenced by internal and external factors that modulate its composition and function. The evidence that gut microbiota composition can differ between healthy and obese individuals, as well as for those who maintain specific dietary habits, has led to the study of this environmental factor as a key link between the pathophysiology of obesity and gut microbiota...
May 15, 2017: BioFactors
https://www.readbyqxmd.com/read/28497908/the-molybdenum-cofactor-enzyme-marc-moonlighting-or-promiscuous-enzyme
#8
REVIEW
Angel Llamas, Alejandro Chamizo-Ampudia, Manuel Tejada-Jimenez, Aurora Galvan, Emilio Fernandez
Molybdenum (Mo) is present in the active center of eukaryotic enzymes as a tricyclic pyranopterin chelate compound forming the Mo Cofactor (Moco). Four Moco containing enzymes are known in eukaryotes, nitrate reductase (NR), sulfite oxidase (SO), xanthine oxidoreductase (XOR), and aldehyde oxidase (AO). A fifth Moco enzyme has been recently identified. Because of the ability of this enzyme to convert by reduction several amidoximes prodrugs into their active amino forms, it was named mARC (mitochondrial Amidoxime Reducing Component)...
May 12, 2017: BioFactors
https://www.readbyqxmd.com/read/28497905/flavanones-citrus-phytochemical-with-health-promoting-properties
#9
REVIEW
Davide Barreca, Giuseppe Gattuso, Ersilia Bellocco, Antonella Calderaro, Domenico Trombetta, Antonella Smeriglio, Giuseppina Laganà, Maria Daglia, Silvia Meneghini, Seyed Mohammad Nabavi
Citrus fruit and juices represent one of the main sources of compounds with a high potential for health promoting properties. Among these compounds, flavanones (such as hesperetin, naringenin, eriodictyol, isosakuranetin, and their respective glycosides), which occur in quantities ranging from ∼180 to 740 mg/L (depending on the Citrus species and cultivar) are responsible for many biological activities. These compounds support and enhance the body's defenses against oxidative stress and help the organism in the prevention of cardiovascular diseases, atherosclerosis, and cancer...
May 12, 2017: BioFactors
https://www.readbyqxmd.com/read/28497879/bone-morphogenetic-protein-5-a-key-molecule-that-mediates-differentiation-in-mc3t3e1-osteoblast-cell-line
#10
Viji Vijayan, Sakshi Gupta, Sarika Gupta
Bone morphogenetic protein-5 (BMP-5) is a member of the TGF receptor-β family with osteoinductive property. However, its physiological role in osteoblast differentiation is not defined. This study highlights the importance of BMP-5 in MC3T3E1 osteoblast differentiation. Pre-osteoblasts exposed to osteogenic media (ascorbic acid, 50 µg/ml and β-glycerophosphate, 10 mM) showed high protein expression of BMP-5 in cell lysates and cell culture supernatants, which peaked during early time-points of differentiation and declined with onset of mineralization...
May 12, 2017: BioFactors
https://www.readbyqxmd.com/read/28419584/context-dependent-function-of-ros-in-the-vascular-endothelium-the-role-of-the-notch-pathway-and-shear-stress
#11
REVIEW
Francesco Vieceli Dalla Sega, Giorgio Aquila, Francesca Fortini, Mauro Vaccarezza, Paola Secchiero, Paola Rizzo, Gianluca Campo
Reactive oxygen species (ROS) act as signal molecules in several biological processes whereas excessive, unregulated, ROS production contributes to the development of pathological conditions including endothelial dysfunction and atherosclerosis. The maintenance of a healthy endothelium depends on many factors and on their reciprocal interactions; in this framework, the Notch pathway and shear stress (SS) play two lead roles. Recently, evidence of a crosstalk between ROS, Notch, and SS, is emerging. The aim of this review is to describe the way ROS interact with the Notch pathway and SS protecting from-or promoting-the development of endothelial dysfunction...
April 17, 2017: BioFactors
https://www.readbyqxmd.com/read/28401997/neuroprotective-effects-of-phloretin-and-its-glycosylated-derivative-on-rotenone-induced-toxicity-in-human-sh-sy5y-neuronal-like-cells
#12
Davide Barreca, Monica Currò, Ersilia Bellocco, Silvana Ficarra, Giuseppina Laganà, Ester Tellone, Maria Laura Giunta, Giuseppa Visalli, Daniela Caccamo, Antonio Galtieri, Riccardo Ientile
Phloretin and phlorizin are the two strong natural antioxidants whose biological and pharmacological applications are rapidly growing in different human pathological conditions. The neuroprotective activity of the two flavonoids has been analyzed on cell culture of neuroblastoma cells. The neuroprotective activity of the two flavonoids has been analyzed on cell culture of neuroblastoma cells and evaluated by testing cell vitality, mitochondrial transmembrane potential and ROS production, antioxidant enzymes detection, activation of caspase 3, DNA damage, protein carbonylation, lipid peroxidation, and superoxide anion scavenging activity...
April 12, 2017: BioFactors
https://www.readbyqxmd.com/read/28394038/hydrogen-sulfide-attenuates-homocysteine-induced-cognitive-deficits-and-neurochemical-alterations-by-improving-endogenous-hydrogen-sulfide-levels
#13
Mohit Kumar, Manish Modi, Rajat Sandhir
Hyperomocysteinemia (HHcy) has been associated with mild cognitive impairment and dementia. Hydrogen sulfide (H2 S) has been suggested to be an endogenous modulator of neuronal functions. However, the effect and mechanisms involved in beneficial effect of H2 S has not been investigated in homocysteine (Hcy)-induced cognitive deficits. This study has been designed to evaluate the effect of exogenous H2 S on behavioral deficits and neurochemical alterations in HHcy animals. Hcy levels were significantly elevated in plasma, cortex, and hippocampus of Hcy administered animals...
April 10, 2017: BioFactors
https://www.readbyqxmd.com/read/28128482/piceatannol-extends-the-lifespan-of-caenorhabditis-elegans-via-daf-16
#14
Peiyi Shen, Yiren Yue, Quancai Sun, Nandita Kasireddy, Kee-Hong Kim, Yeonhwa Park
Piceatannol is a natural stilbene with many beneficial effects, such as antioxidative, anti-inflammatory, antiatherogenic activities; however, its role on aging is not known. In this study, we used Caenorhabditis elegans as an animal model to study the effect of piceatannol on its lifespan and investigated the underlying mechanisms. The results showed that 50 and 100 µM piceatannol significantly extended the lifespan of C. elegans without altering the growth rate, worm size and progeny production. Piceatannol delayed the age-related decline of pumping rate and locomotive activity, and protected the worms from heat and oxidative stress...
May 6, 2017: BioFactors
https://www.readbyqxmd.com/read/28317262/hydroxytyrosol-restores-proper-insulin-signaling-in-an-astrocytic-model-of-alzheimer-s-disease
#15
M Carmen Crespo, Joao Tomé-Carneiro, Cristina Pintado, Alberto Dávalos, Francesco Visioli, Emma Burgos-Ramos
Recent epidemiological evidence demonstrated that diabetes is a risk factor for AD onset and development. Indeed, meta-analyses of longitudinal epidemiologic studies show that diabetes increases AD risk by 50-100%, being insulin resistance (IR) the main binding link between diabetes and AD. Astrocytes are the foremost cerebral macroglial cells and are responsible for converting glucose into lactate and transfer it to neurons that use it as fuel, but Aβ(1-42) impairs insulin signaling and glycogen storage. Recent prospective studies showed that the Mediterranean diet is associated with lower incidence of AD...
March 20, 2017: BioFactors
https://www.readbyqxmd.com/read/28317253/correlation-between-the-potency-of-flavonoids-for-cytochrome-c-reduction-and-inhibition-of-cardiolipin-induced-peroxidase-activity
#16
Ricardo Lagoa, Alejandro K Samhan-Arias, Carlos Gutierrez-Merino
There are large differences between flavonoids to protect against apoptosis, a process in which cytochrome c (Cyt c) plays a key role. In this work, we show that 7 of 13 flavonoids studied have a capacity to reduce Cyt c similar or higher than ascorbate, the flavonols quercetin, kaempferol and myricetin, flavanol epigallocatechin-gallate, anthocyanidins cyanidin and malvidin, and the flavone luteolin. In contrast, the kaempferol 3(O)- and 3,4'(O)-methylated forms, the flavanone naringenin, and also apigenin and chrysin, had a negligible reducing capacity...
March 20, 2017: BioFactors
https://www.readbyqxmd.com/read/28251705/selenium-supplementation-modulates-apoptotic-processes-in-thyroid-follicular-cells
#17
Immacolata C Nettore, Emma De Nisco, Silvio Desiderio, Carmela Passaro, Luigi Maione, Mariarosaria Negri, Luigi Albano, Rosario Pivonello, Claudia Pivonello, Giuseppe Portella, Paola Ungaro, Annamaria Colao, Paolo E Macchia
Selenium (Se) is an essential micronutrient modulating several physiopathological processes in the human body. The aim of the study is to characterize the molecular effects determined by Se-supplementation in thyroid follicular cells, using as model the well-differentiated rat thyroid follicular cell line FRTL5. Experiments have been performed to evaluate the effects of Se on cell growth, mortality and proliferation and on modulation of pro- and antiapoptotic pathways. The results indicate that Se-supplementation improves FRTL5 growth rate...
March 2, 2017: BioFactors
https://www.readbyqxmd.com/read/28419655/cytokine-and-adipokine-are-biofactors-can-act-in-blood-and-colostrum-of-obese-mothers
#18
Mahmi Fujimori, Eduardo Luzia França, Tassiane Cristina Morais, Vanessa Fiorin, Luiz Carlos de Abreu, Adenilda Cristina Honório-França
Breast milk contains bioactive components that contribute to newborn development. However, colostrum may undergo biochemical and immunological changes as a function of maternal overweight and obesity. To investigate this hypothesis, this study determined the levels of hormones and immunological markers in the serum and colostrum of overweight and obese mothers. Colostrum and serum samples were collected from 15 normoweight, 15 overweight, and 15 obese women for determination of leptin, adiponectin, cytokines (TNF-α, IL-6, IL-10), and C-reactive protein (CRP)...
March 2017: BioFactors
https://www.readbyqxmd.com/read/28247504/epigallocatechin-3-gallate-augments-the-therapeutic-effects-of-benzo-a-pyrene-mediated-lung-carcinogenesis
#19
Meghan M Cromie, Zhongwei Liu, Weimin Gao
Our previous study found curcumin and vitamin E to have protective effects against benzo[a]pyrene (BaP) exposure in human normal lung epithelial BEAS-2B cells. The first objective of this study was to determine whether epigallocatechin-3-gallate (EGCG) elicited the same response. Co-treatment with 5 µM BaP and 20 µM EGCG in BEAS-2B promoted a significant reduction in cell viability and greater G2/M cell cycle arrest, induction of ROS, and reductions in BaP-induced CYP1A1/CYP1B1/COMT, EGFR, p-Akt (Ser473), p-p53 (Thr55), and survivin mRNA/protein expression, as well as an increase in p-p53 (Ser15)...
March 1, 2017: BioFactors
https://www.readbyqxmd.com/read/28186649/bone-morphogenetic-protein-7-bmp-7-augments-insulin-sensitivity-in-mice-with-type-ii-diabetes-mellitus-by-potentiating-pi3k-akt-pathway
#20
Tandrika Chattopadhyay, Rajiv Ranjan Singh, Sarika Gupta, Avadhesha Surolia
A direct link between development of insulin resistance and the presence of chronic inflammation, in case of obesity exists, with cytokines playing an important role in glucose metabolism. Members of TGF-β superfamily, including bone morphogenetic proteins (BMPs), have been shown to be involved in islet morphogenesis, establishment of β-cell mass and adipose cell fate determination. Here, we demonstrate a novel and direct role of BMP-4 and -7 in the regulation of glucose homeostasis and insulin resistance...
March 2017: BioFactors
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