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BioFactors

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https://www.readbyqxmd.com/read/29064586/a-pivotal-role-of-ampk-signaling-in-medicarpin-mediated-formation-of-brown-and-beige-adipocytes-from-c3h10t1-2-mesenchymal-stem-cells
#1
Khan Mohammad Imran, Dahyeon Yoon, Yong-Sik Kim
Obesity poses a substantial threat of a worldwide epidemic and requires better understanding of adipose-tissue biology as well as necessitates research into the etiology and therapeutic interventions. In this study, Medicarpin (Med), a natural pterocarpan, was selected (by screening) as a small-molecule inducer of adipocyte differentiation among 854 candidates by using C3H10T1/2 mesenchymal stem cell; a cellular model of adipogenesis. Med induced the expression of brown-adipocyte commitment marker Bmp7 as well as the early regulators of brown fat fate Pparγ, Prdm16, and Pgc-1α during differentiation of C3H10T1/2 mesenchymal stem cells...
October 24, 2017: BioFactors
https://www.readbyqxmd.com/read/29048780/magnesium-isoglycyrrhizinate-promotes-the-activated-hepatic-stellate-cells-apoptosis-via-endoplasmic-reticulum-stress-and-ameliorates-fibrogenesis-in-vitro-and-in-vivo
#2
Mianli Bian, Xingran Chen, Chenxi Zhang, Huanhuan Jin, Feixia Wang, Jiangjuan Shao, Anping Chen, Feng Zhang, Shizhong Zheng
Varied pathogenetic elements have been touched upon the liver fibrosis, including inflammatory, stress, apoptosis and unfolded proteins aggregation. Magnesium Isoglycyrrhizinate (MgIG) has been accepted to be a neuroprotective effect, hepatoprotective and anti-inflammatory molecule. In our vitro researches, MgIG was considered to activate hepatic stellate cells (HSCs) apoptosis by promoting endoplasmic reticulum stress (ERS) detrimental response to a certain extent. Consequently, MgIG showed its potential therapeutic capacity in fibrogenesis and counteracted the pathogenetic aspects, which were involved in integrating current treatments correcting liver fibrosis...
October 19, 2017: BioFactors
https://www.readbyqxmd.com/read/29048765/ageratum-conyzoides-l-inhibits-5-alpha-reductase-gene-expression-in-human-prostate-cells-and-reduces-symptoms-of-benign-prostatic-hypertrophy-in-otherwise-healthy-men-in-a-double-blind-randomized-placebo-controlled-clinical-study
#3
Matthew Detering, Elizabeth Steels, Sundar Rao Koyyalamudi, Elena Allifranchini, Elena Bocchietto, Luis Vitetta
A double-blind, randomized, placebo-controlled clinical trial assessed the efficacy and safety of Ageratum conyzoides in treating benign prostatic hypertrophy (BPH). In this study, 109 men with medically diagnosed BPH, aged 41-76 years, were administered the investigational product, A. conyzoides extract at a dose of 250 mg/d or placebo, q.d. for 12 weeks. The primary outcome measures were the International Prostate Symptom Score (IPSS), daily urinary frequency and safety evaluations. The secondary outcome measures were testosterone, dihydrotestosterone, oestradiol, sex hormone binding globulin (SHBG), Dehydroepiandrosterone sulfate (DHEA-S) and cortisol levels, and prostate specific antigen (PSA), lipids, blood glucose, the Aging Male's Symptom (AMS) Score and sexual function assessed by Derogatis Interview for Sexual Functioning-Self Report (DISF-SR)...
October 19, 2017: BioFactors
https://www.readbyqxmd.com/read/28922499/antioxidants-wonder-drugs-or-quackery
#4
REVIEW
Angelo Azzi
An answer to the question posed by the title must be simple not to disturb in his tomb Albert Einstein, who wrote "Man muß die Dinge so einfach wie möglich machen. Aber nicht einfacher". A simple answer (not simpler) can be: Antioxidants are not antioxidants, they are not wonder drugs and they are not all quackery; but they are not nothing. The arguments in support of this conundrumic statement will be developed below. © 2017 BioFactors, 2017.
September 18, 2017: BioFactors
https://www.readbyqxmd.com/read/28881099/renal-protective-and-ameliorating-impacts-of-omega-3-fatty-acids-against-aspartame-damaged-mdck-cells
#5
Muthuraman Pandurangan, Gansukh Enkhtaivan, Muthuviveganandavel Veerappan, Bhupendra Mistry, Rahul Patel, So Hyun Moon, Patnamsetty Chidanandha Nagajyothi, Doo Hwan Kim
Aspartame is widely used artificial sweeteners as food additives. Several researchers have pointed that the controversial report on the use of aspartame over more than decades. Omega-3 fatty acids are essential and unsaturated fatty acids, and it plays a remarkable role in vision, intelligence, neural development, and metabolism of neurotransmitters. Therefore, the present study was aimed to investigate the effect of omega-3 fatty acids on aspartame treated renal cells. Experimental groups were divided into three such as sham control, aspartame treated, and aspartame with omega-3 fatty acids...
September 7, 2017: BioFactors
https://www.readbyqxmd.com/read/28845600/implications-of-impaired-zinc-homeostasis-in-diabetic-cardiomyopathy-and-nephropathy
#6
REVIEW
Robertina Giacconi, Lu Cai, Laura Costarelli, Maurizio Cardelli, Marco Malavolta, Francesco Piacenza, Mauro Provinciali
Impaired zinc homeostasis is observed in diabetes mellitus (DM2) and its complications. Zinc has a specific role in pancreatic β-cells via insulin synthesis, storage, and secretion. Intracellular zinc homeostasis is tightly controlled by zinc transporters (ZnT and Zip families) and metallothioneins (MT) which modulate the uptake, storage, and distribution of zinc. Several investigations in animal models demonstrate the protective role of MT in DM2 and its cardiovascular or renal complications, while a copious literature shows that a common polymorphism (R325W) in ZnT8, which affects the protein's zinc transport activity, is associated with increased DM2 risk...
August 27, 2017: BioFactors
https://www.readbyqxmd.com/read/28984393/in-memory-of-tommaso-galeotti
#7
Angelo Azzi
No abstract text is available yet for this article.
September 10, 2017: BioFactors
https://www.readbyqxmd.com/read/28759135/acute-and-long-term-administration-of-palmitoylcarnitine-induces-muscle-specific-insulin-resistance-in-mice
#8
Edgars Liepinsh, Marina Makrecka-Kuka, Elina Makarova, Kristine Volska, Karlis Vilks, Eduards Sevostjanovs, Unigunde Antone, Janis Kuka, Reinis Vilskersts, Daina Lola, Einars Loza, Solveiga Grinberga, Maija Dambrova
Acylcarnitine accumulation has been linked to perturbations in energy metabolism pathways. In this study, we demonstrate that long-chain (LC) acylcarnitines are active metabolites involved in the regulation of glucose metabolism in vivo. Single-dose administration of palmitoylcarnitine (PC) in fed mice induced marked insulin insensitivity, decreased glucose uptake in muscles, and elevated blood glucose levels. Increase in the content of LC acylcarnitine induced insulin resistance by impairing Akt phosphorylation at Ser473...
September 10, 2017: BioFactors
https://www.readbyqxmd.com/read/28753257/caffeic-acid-attenuates-the-inflammatory-stress-induced-by-glycated-ldl-in-human-endothelial-cells-by-mechanisms-involving-inhibition-of-age-receptor-oxidative-and-endoplasmic-reticulum-stress
#9
Laura Toma, Gabriela M Sanda, Loredan S Niculescu, Mariana Deleanu, Camelia S Stancu, Anca V Sima
Type 2 diabetes mellitus is a worldwide epidemic and its atherosclerotic complications determine the high morbidity and mortality of diabetic patients. Caffeic acid (CAF), a phenolic acid present in normal diets, is known for its antioxidant properties. The aim of this study was to investigate CAF's anti-inflammatory properties and its mechanism of action, using cultured human endothelial cells (HEC) incubated with glycated low-density lipoproteins (gLDL). Levels of the receptor for advanced glycation end-products (RAGE), inflammatory stress markers (C reactive protein, CRP; vascular cell adhesion molecule-1, VCAM-1; monocyte chemoattractant protein-1, MCP-1), and oxidative stress and endoplasmic reticulum stress (ERS) markers were evaluated in gLDL-exposed HEC, in the presence/absence of CAF...
September 10, 2017: BioFactors
https://www.readbyqxmd.com/read/28742266/p-coumaric-acid-a-dietary-polyphenol-ameliorates-inflammation-and-curtails-cartilage-and-bone-erosion-in-the-rheumatoid-arthritis-rat-model
#10
Manoj Kumar Neog, Samuel Joshua Pragasam, Moorthy Krishnan, Mahaboobkhan Rasool
This study was designed to explore the underlying mechanism of p-coumaric acid (CA), a dietary polyphenol in adjuvant-induced arthritis (AIA) rat model with reference to synovitis and osteoclastogenesis. Celecoxib (COX-2 selective inhibitor) (5 mg/kg b.wt) was used as a reference drug. CA remarkably suppressed the paw edema, body weight loss and inflammatory cytokine and chemokine levels (TNF-α, IL-1β, IL-6, and MCP-1) in serum and ankle joint of arthritic rats. Consistently, CA reduced the expression of osteoclastogenic factors (RANKL and TRAP), pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-17), and inflammatory enzymes (iNOS and COX-2) in arthritic rats...
September 10, 2017: BioFactors
https://www.readbyqxmd.com/read/28719149/cadmium-induced-toxicity-is-rescued-by-curcumin-a-review
#11
REVIEW
Mohammad Mohajeri, Mehdi Rezaee, Amirhossein Sahebkar
Cadmium (Cd) is one of the most common environmental and occupational heavy metals with extended distribution. Exposure to Cd may be associated with several deleterious consequences on the liver, bones, kidneys, lungs, testes, brain, immunological, and cardiovascular systems. Overproduction of reactive oxygen species (ROS) as the main mechanism behind its toxicity causes oxidative stress and subsequent damages to lipids, proteins, and DNA. Therefore, antioxidants along with chelating agents have shown promising outcomes against Cd-induced toxicity...
September 10, 2017: BioFactors
https://www.readbyqxmd.com/read/28718997/mesenchymal-stem-cell-derived-factors-immuno-modulatory-effects-and-therapeutic-potential
#12
REVIEW
Vladislav Volarevic, Marina Gazdic, Bojana Simovic Markovic, Nemanja Jovicic, Valentin Djonov, Nebojsa Arsenijevic
Stem cell-based therapy is considered to be a new hope in transplantation medicine. Among stem cells, mesenchymal stem cells (MSCs) are, due to their differentiation and immuno-modulatory characteristics, the most commonly used as therapeutic agents in the treatment of immune-mediated diseases. MSCs migrate to the site of inflammation and modulate immune response. The capacity of MSC to alter phenotype and function of immune cells are largely due to the production of soluble factors which expression varies depending on the pathologic condition to which MSCs are exposed...
September 10, 2017: BioFactors
https://www.readbyqxmd.com/read/28703385/arsenite-induces-dna-damage-via-mitochondrial-ros-and-induction-of-mitochondrial-permeability-transition
#13
Andrea Guidarelli, Mara Fiorani, Liana Cerioni, Maddalena Scotti, Orazio Cantoni
Arsenite is an established DNA-damaging agent and human carcinogen. We initially selected conditions in which the metalloid causes DNA strand scission in the absence of detectable apoptotic DNA degradation in U937 cells. This response was suppressed by catalase and by treatments (rotenone and ascorbic acid), or manipulations (respiration-deficient phenotype), preventing the mitochondrial formation of O2-. ( mitoO2-.). MitoO2-., and its dismutation product, H2 O2 , are therefore critically involved in the arsenite-dependent DNA-damaging response...
September 10, 2017: BioFactors
https://www.readbyqxmd.com/read/28613019/a-mystery-of-a-cup-of-coffee-an-insight-look-by-chemist
#14
REVIEW
Joanna Karpinska, Renata Świsłocka, Włodzimierz Lewandowski
Fruits, vegetables as well as processed food products of plant origin are a rich source of beneficial for human health constituents. Among them the polyphenols constitute a large group of compounds. The presented literature survey is devoted to chlorogenic acid the most abundant representative of cinnamate acids esters. Its chemical as well as biological properties are described. © 2017 BioFactors, 43(5):621-632, 2017.
September 10, 2017: BioFactors
https://www.readbyqxmd.com/read/28608644/ezrin-as-a-possible-diagnostic-and-or-prognostic-biomarker-in-mice-lymphatic-metastatic-hepatocellular-carcinoma-in-vivo
#15
Ahmed Musa Hago Bakheet, Salma Abdi Mahmoud, Yuhong Huang, Jun Zhang, Jingwen Wang, Yuanyi Wei, Yaser Gamallat, Annoor Awadasseid, Lawrence Owusu, Yousra Khidir, Li Wang, Shuting Zhou, Pawan Kumar Seewooruttun, Boyi Xin, Wei Xuan, Zhen Su, Jianwu Tang
Hepatocellular carcinoma (HCC) ranks in the top of cancers leading to death. Early diagnosis is the big challenge in the case of HCC. Our in vitro study showed that Ezrin expression in lymphatic metastasis hepatocellular carcinoma (LNM-HCC) was associated with the metastatic rate. Here we aim to evaluate Ezrin expression as diagnostic and/or prognostic biomarker of LNM-HCC in mice. Chinese inbred 615 mice, Hca-F and Hca-P cell lines were used in the study. Histological changes were determined by Hematoxylin and Eosin, while Ezrin expression was assessed by qRT-PCR, western blot, immunohistochemistry, and enzyme-linked immunosorbent assay...
September 10, 2017: BioFactors
https://www.readbyqxmd.com/read/28817221/neuroprotective-effects-of-honokiol-from-chemistry-to-medicine
#16
REVIEW
Sylwia Talarek, Joanna Listos, Davide Barreca, Ester Tellone, Antoni Sureda, Seyed Fazel Nabavi, Nady Braidy, Seyed Mohammad Nabavi
The incidence of neurological disorders is growing in developed countries together with increased lifespan. Nowadays, there are still no effective treatments for neurodegenerative pathologies, which make necessary to search for new therapeutic agents. Natural products, most of them used in traditional medicine, are considered promising alternatives for the treatment of neurodegenerative diseases. Honokiol is a natural bioactive phenylpropanoid compound, belonging to the class of neolignan, found in notable amounts in the bark of Magnolia tree, and has been reported to exert diverse pharmacological properties including neuroprotective activities...
August 17, 2017: BioFactors
https://www.readbyqxmd.com/read/28817203/the-combination-of-digoxin-and-gsk2606414-exerts-synergistic-anticancer-activity-against-leukemia-in-vitro-and-in-vivo
#17
Xue-Hong Zhang, Xin-Yu Wang, Zhi-Wei Zhou, Hua Bai, Lin Shi, Yin-Xue Yang, Shu-Feng Zhou, Xiao-Chun Zhang
Digoxin is a member of cardiac glycosides and recent studies show that digoxin plays anticancer role in several types of cancer. However, the anticancer effects and mechanism of digoxin in leukemia is largely unknown. Her, our data show that digoxin treatment significantly inhibits leukemia cell viability. In addition, digoxin treatment significantly induced apoptosis and G2/M cell cycle arrest in leukemia cells. Furthermore, we demonstrated that digoxin treatment inactivate that oncogenic pathway Akt/mTOR signaling in leukemia cells...
August 17, 2017: BioFactors
https://www.readbyqxmd.com/read/28799667/coadministration-of-isomalto-oligosaccharides-augments-metabolic-health-benefits-of-cinnamaldehyde-in-high-fat-diet-fed-mice
#18
Dhirendra Pratap Singh, Pragyanshu Khare, Vandana Bijalwan, Ritesh Kumar Baboota, Jagdeep Singh, Kanthi Kiran Kondepudi, Kanwaljit Chopra, Mahendra Bishnoi
Bacteriostatic properties of a potential anti-obesity agent cinnamaldehyde (CMN) may present untoward effects on the resident gut microbiota. Here, we evaluated whether the combination of Isomalto-oligosaccharides (IMOs) with CMN prevents unwanted effects of CMN on gut microbiota and associated metabolic outcomes in HFD-fed mice. Male Swiss albino mice divided into four groups (n = 10), were fed on normal chow, or HFD (58% fat kcal), HFD + CMN (10 mg kg(-1) ) and HFD + CMN (10 mg kg(-1) ) + IMOs (1 g kg(-1) ) for 12 weeks...
August 11, 2017: BioFactors
https://www.readbyqxmd.com/read/28786551/differentially-activated-src-kinase-in-chemo-na%C3%A3-ve-human-primary-osteosarcoma-cells-and-effects-of-a-src-kinase-inhibitor
#19
Marcella Laschi, Giulia Bernardini, Michela Geminiani, Fabrizio Manetti, Mattia Mori, Adriano Spreafico, Domenico Campanacci, Rodolfo Capanna, Silvia Schenone, Maurizio Botta, Annalisa Santucci
The therapeutic treatment of osteosarcoma (OS), a rare malignant teenage cancer of the skeletal system, still represents a great challenge as patient survival after conventional protocol chemotherapy treatment has not improved in the last four decades leaving poor patient prognoses. Therefore, many efforts have been done to find increasingly reliable OS cell models and to identify "druggable" targets in OS, in order to identify novel effective therapeutic approaches and treatment strategies. In this contest, the more successful use of patient-derived cell cultures in respect to human commercial lines and findings of Src kinase deregulation in cancer, prompted us to study for the first time the activation state of Src and the potential activity of our Src inhibitor SI-83 in a number of chemo-naïve patient-derived primary OS cells...
August 8, 2017: BioFactors
https://www.readbyqxmd.com/read/28753256/a-novel-moonlight-function-of-glyceraldehyde-3-phosphate-dehydrogenase-gapdh-for-immunomodulation
#20
Toshiaki Nakano, Shigeru Goto, Yuki Takaoka, Hui-Peng Tseng, Takashi Fujimura, Seiji Kawamoto, Kazuhisa Ono, Chao-Long Chen
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an energy metabolism-related enzyme, which generates NADH in glycolysis. Our previous study revealed a novel role of exogenous GAPDH in the amelioration of lipopolysaccharide (LPS)-induced sepsis-related, severe acute lung injury (ALI) in mice. Here, we show the effect of extracellular GAPDH on the physiological functions of macrophages, which play an important role in the onset of sepsis and ALI. GAPDH has no effect on cell viability, while it strongly suppressed cell adhesion, spreading, and phagocytic function of LPS-stimulated macrophages...
July 28, 2017: BioFactors
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