Sheida Koohsari, Faranak Ebrahimian Sadabad, Brian Pittman, Jean-Dominque Gallezot, Richard E Carson, Christopher H van Dyck, Chiang-Shan R Li, Marc N Potenza, David Matuskey
Previous research reported an age-related decline in brain norepinephrine transporter (NET) using (S, S)-[11C]O-methylreboxetine ([11C]MRB) as a radiotracer. Studies with the same tracer have been mixed in regard to differences related to body mass index (BMI). Here, we investigated potential age-, BMI-, and gender-related differences in brain NET availability using [11C]MRB, the most selective available radiotracer. Forty-three healthy participants (20 females, 23 males; age range 18-49 years), including 12 individuals with normal/lean weight, 15 with overweight, and 16 with obesity were scanned with [11C]MRB using a positron emission tomography (PET) high-resolution research tomograph (HRRT)...
June 29, 2023: Synapse