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In Vivo

Anna C Lohman, Ingrid VAN Rijn, Christina L Lindhardt, Reinhard Vonthein, Dirk Rades, Niels Henrik Holländer
BACKGROUND/AIM: If blood tests were performed at home, unnecessary trips of patients for chemotherapy could be avoided. The HemoCue® WBC DIFF device was tested at home by 14 patients with breast cancer. MATERIALS AND METHODS: A total of 42 measurements of white blood cell (WBC) and neutrophil counts with the device at home were compared to laboratory measurements performed within 3 hours. Bland-Altman plots were created for limits of agreement that should be less than 1...
September 2018: In Vivo
Ahmed El-Balat, Iryna Schmeil, Thomas Karn, Uwe Holtrich, Loreta Mavrova-Risteska, Achim Rody, Aly Youssef, Lars C Hanker
BACKGROUND/AIM: Totally implanted venous access devices (TIVAD) are increasingly used in the treatment of cancer patients. The aim of this study was to assess the incidence of early and late complications resulting from subcutaneous TIVADs in patients with breast cancer. MATERIALS AND METHODS: Between 2004 and 2009, we reviewed patients with breast cancer who had a TIVAD placed. Early and late complications, as well as risk factors for TIVAD-associated thrombosis were retrospectively assessed...
September 2018: In Vivo
Ichiro Ogino, Shigenobu Watanabe, Kingo Hirasawa, Toshihoro Misumi, Masaharu Hata, Chikara Kunisaki
AIM: To evaluate whether patients with T1 esophageal squamous cell carcinoma receiving definitive radiotherapy can be managed without concurrent chemotherapy, and the role of 18 F-fluorodeoxyglucose positron-emission tomography with computed tomography (FDG-PET/CT) in demonstrating local control (LC). PATIENTS AND METHODS: Twenty-four out of 37 patients with newly-diagnosed T1 EC treated with definitive radiotherapy between July 2009 and July 2016 were retrospectively analyzed...
September 2018: In Vivo
Marilita M Moschos, Konstantinos Laios, Anastasios Lavaris, Christos Damaskos, Nikolaos Garmpis, Ahmed Thabit, Damian Lake, Samer Hamada, Anna Garmpi, Zisis Gatzioufas
BACKGROUND/AIM: Cataract is the leading cause of reversible blindness and visual impairment worldwide. Although cataract surgery using phacoemulsification and intraocular lens (IOL) implantation is one of the commonest surgical procedures, IOL opacification remains a potential complication that can affect the visual outcome of the operation. CASE REPORT: A 50-year-old female patient presented to our clinic complaining of glare and blurry vision in her right eye over the previous 6 weeks...
September 2018: In Vivo
Zita Kreska, Balázs Németh, István Kiss, Iván Péter, Zénó Ajtay, László Hejjel
BACKGROUND: The aim of this study was to investigate the effects of carbon-dioxide treatment on heart rate variability (HRV) parameters: mean RR interval (RRI), standard deviation of RR intervals (SDNN), root mean square of successive RR differences (RMSSD); and Porta and Guzik indices, as measures of heart rate asymmetry. MATERIALS AND METHODS: Twenty patients were enrolled (mean±SD, age=59±7.8 years). Measurements were performed before CO2 treatment, at the beginning of treatment, at 15 min of treatment, immediately after and 1 h after the treatment...
September 2018: In Vivo
Emanuela Zappulo, Maria Pia Riccio, Sandro Binda, Laura Pellegrinelli, Fabrizio Pregliasco, Antonio Riccardo Buonomo, Biagio Pinchera, Giordano D'Urso, Carmela Bravaccio, Guglielmo Borgia, Ivan Gentile
BACKGROUND/AIM: Etiopathogenesis of autism spectrum disorders (ASD) remains to be elucidated. Congenital infections, particularly viral infections, have repeatedly been associated with the onset of such disorders. Our study aimed at assessing the prevalence of herpes simplex type 1 and 2 (HSV1/2) congenital infections in patients with ASD. MATERIALS AND METHODS: In our case-control study, a total of 38 children with ASD were compared to 44 age- and sex-matched controls regarding the presence of HSV1/2 infection though viral DNA polymerase chain reaction performed on dried blood spots collected at birth...
September 2018: In Vivo
Nicolae Bacalbasa, Irina Balescu, Veronica Ilie, Raluca Florea, Andrei Sorop, Vladislav Brasoveanu, Iulian Brezean, Mihaela Vilcu, Simona Dima, Irinel Popescu
BACKGROUND/AIM: Breast cancer remains one of the most frequently encountered malignancies worldwide, which is in most cases diagnosed in early stages of disease. However, although surgery and adjuvant oncological treatment are performed with curative intent, a certain number of cases will develop distant metastases. In cases presenting oligometastatic disease, surgery might be tempted in order to maximize the benefit in terms of survival. The aim of this paper was to identify which cases could benefit most after liver resection for breast cancer liver metastases...
September 2018: In Vivo
Nikolaos Georgakopoulos, Panagiotis Diamantopoulos, Francesca Micci, Nefeli Giannakopoulou, Konstantinos Zervakis, Aglaia Dimitrakopoulou, Nora-Athina Viniou
This is a case report of a 46-year-old man diagnosed with early pre-B acute lymphoblastic leukemia (ALL), bearing the translocation t(12;17)(p13;q21) as the sole chromosomal abnormality. This is a rare chromosomal abnormality that has been reported in approximately 25 cases worldwide. FISH analysis revealed a rearrangement of ZNF384 (12p13) and TAF15 (17q12) genes, which is usually associated with a pre-B ALL phenotype with co-expression of the myeloid markers CD13 and/or CD33. ZNF384 encodes a zinc finger protein, which acts as a transcription factor, regulating the expression of several matrix metalloproteinases and TAF15 belongs to the FET (FUS, EWS, and TAF15) family, consisting of RNA and DNA-binding proteins...
September 2018: In Vivo
Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Toshiaki Tanaka, Takeshi Nishikawa, Kensuke Otani, Kazuhito Sasaki, Manabu Kaneko, Shigenobu Emoto, Koji Murono
BACKGROUND/AIM: Several risk factors for recurrence have been identified in stage II colorectal cancer. However, in contrast to stage III, the benefits of adjuvant chemotherapy for these patients remain controversial. We hypothesized that the different impacts of chemotherapy may be due to different patterns of recurrence between these stages. The aim of this study was to characterize recurrence in high-risk stage II colorectal cancer (CRC) in comparison with stage III. PATIENTS AND METHODS: A total of 442 patients with curatively resected stage III and high-risk stage II CRCs were evaluated...
September 2018: In Vivo
Filippo Crimì, Giulia Camporese, Carmelo Lacognata, Giuseppe Fanelli, Diego Cecchin, Marco Zoccarato
This is a case report of a 17-year-old girl affected by N-methyl-D-aspartate-receptor (NMDAR) encephalitis suspected for a paraneoplastic syndrome. Ultrasound (US) and computed tomography (CT) imaging identified an ovarian lesion compatible with teratoma. 18 F-fluorodeoxyglucose (FDG) positron emission tomography/magnetic resonance imaging (PET/MRI), performed to evaluate metabolic activity of the brain and of the ovarian mass, correctly changed the diagnosis to uterine malformation that was later histologically proven...
September 2018: In Vivo
Simo Karhi, Ossi Nerg, Tuuli Miettinen, Emmi Mäkipaakkanen, Mikko Taina, Hannu Manninen, Ritva Vanninen, Pekka Jäkälä
AIM: Recent trials have established the benefit of endovascular treatment (EVT) for patients with acute ischemic stroke (AIS) due to large artery occlusion (LAO). However, older patients were often excluded from trials. EVT outcomes were retrospectively compared between octogenarians and younger patients treated for LAO in a tertiary hospital. PATIENTS AND METHODS: A total of 199 consecutive patients with anterior circulation AIS that underwent EVT between 2009 and 2015 in the Kuopio University Hospital were included...
September 2018: In Vivo
Nicolae Bacalbasa, Irina Balescu, Mihai Pautov, Julian Brezean, Mihaela Vilcu, Vladislav Brasoveanu
BACKGROUND: A proper knowledge of the anatomy of the liver (including its vascular particularities) is mandatory in cases which are going to be submitted to major hepatic resection, including living donor liver transplantation. CASE REPORT: We present the case of a living donor liver transplantation in which a particularity of the anatomy of the hepatic veins was reported for the donor: two inferior hepatic veins for segments 5 and 6. This particularity imposed the need for creation of a supplemental anastomosis in the recipient: a phleboplasty of the two inferior veins followed by direct re-implantation into the inferior cava vein...
September 2018: In Vivo
Tsutomu Namikawa, Nobuko Ishida, Sachi Tsuda, Kazune Fujisawa, Eri Munekage, Jun Iwabu, Masaya Munekage, Sunao Uemura, Shigehiro Tsujii, Hiromichi Maeda, Hiroyuki Kitagawa, Michiya Kobayashi, Kazuhiro Hanazaki
A pathological complete response (pCR) to treatment for gastric cancer is a rare event, even when powerful treatment regimens are used. Herein, a case of 61-year-old male referred to our hospital with advanced gastric cancer who achieved a pCR following chemotherapy using S-1, and subsequently underwent total gastrectomy is reported. His initial esophagogastroduodenoscopy (EGD) revealed an irregular, nodular, ulcerated lesion in the upper third of the stomach that was analyzed by biopsy to be a moderately differentiated adenocarcinoma...
September 2018: In Vivo
Moegi Komura, Shigehiro Yagishita, Kota Nakamura, Naoko Arano, Tomohito Takeshige, Keiko Muraki, Osamu Nagashima, Hiroshi Izumi, Shigeki Tomita, Shinichi Sasaki, Kazuhisa Takahashi
A 28-year-old woman who was 34 weeks pregnant was admitted with complaints of cough and blood-stained sputum. After delivery of the baby at 37 weeks gestation, computed tomography and magnetic resonance imaging revealed a tumor in the right lung and a 15-mm brain metastasis. A diagnosis of lung adenocarcinoma was made, cT4N3M1b (stage IV disease) by pleural fluid cytology. Additional testing for anaplastic lymphoma kinase (ALK) fusion protein showed a strongly positive result, which was then confirmed by fluorescence in situ hybridization...
September 2018: In Vivo
Yoshihito Kogure, Fumie Shigematsu, Masahide Oki, Hideo Saka
BACKGROUND/AIM: The aim of this study was to evaluate the relationship between T790M status and the characteristics of non-small cell lung cancer (NSCLC) patients undergoing rebiopsy after initial epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy and whether the site of rebiopsy has an effect on the detection rate for T790M in these patients. MATERIALS AND METHODS: We retrospectively reviewed the clinical data from stage IV or recurrent NSCLC patients who harbored EGFR mutations and who had initially received EGFR-TKI at our Center from January 2009 to December 2016...
September 2018: In Vivo
Hidenori Suzuki, Tsuneo Tamaki, Masami Nishio, Shintaro Beppu, Nobuaki Mukoyama, Nobuhiro Hanai, Daisuke Nishikawa, Yusuke Koide, Yasuhisa Hasegawa
BACKGROUND/AIM: To predict survival outcomes of different patients with the same stage of disease is difficult. The possible correlation between 18 F-fluorodeoxyglucose (18 F-FDG) uptake parameters and survival outcomes was investigated in oral squamous cell carcinoma patients by multivariate analysis adjusted for the pathological stage according to the 8th edition of the tumor-node-metastasis (TNM) classification of the Union for International Cancer Contro. PATIENTS AND METHODS: 18 F-FDG-uptake parameters of 28 patients were assessed by positron emission tomography with computed tomography (PET/CT)...
September 2018: In Vivo
Hirofumi Kamachi, Yousuke Tsuruga, Tatsuya Orimo, Kenji Wakayama, Shingo Shimada, Akihisa Nagatsu, Hideki Yokoo, Toshiya Kamiyama, Norio Katoh, Akinobu Taketomi
BACKGROUND: Local antitumor efficacy and the outcome of neoadjuvant chemoradiotherapy (NACRT) with low-dose gemcitabine and wide irradiation area for borderline resectable and unresectable pancreatic cancer were evaluated. PATIENTS AND METHODS: Thirty-four cases of borderline resectable and unresectable pancreatic cancer were recruited. Three-dimensional conformal radiotherapy to the pancreatic bed and the region scheduled for lymph node dissection was performed to a total dose of 50...
September 2018: In Vivo
Aleksandra Sobczyńska-Rak, Beata Żylińska, Łukasz Jarosz, Adam Brodzki, Marcin Tatara
BACKGROUND/AIM: Neoplastic lesions of perianal glands account for approximately 10% of all skin cancer cases in dogs. They occur in many dog breeds, usually in male animals aged over 6 years. Due to their hormone-dependency, tamoxifen can be used in antineoplastic treatment. The aim of the study was to measure epidermal growth factor (EGF) levels in the serum of dogs with perianal tumours after tamoxifen treatment and to use it as a prognostic factor for further treatment. MATERIALS AND METHODS: The study was performed on 19 male dogs aged between 6 and 14 years, diagnosed with neoplastic hyperplasia in the perianal region...
September 2018: In Vivo
Yoshiki Negi, Kozo Kuribayashi, Norihiko Funaguchi, Hiroshi Doi, Koji Mikami, Toshiyuki Minami, Teruhisa Takuwa, Takashi Yokoi, Seiki Hasegawa, Takashi Kijima
BACKGROUND/AIM: A strategy for improving survival of malignant pleural mesothelioma (MPM) patients is earlier diagnosis paired with earlier stage implementation of therapeutic interventions. This study aimed to determine the clinical signs of early-stage MPM to aid an earlier diagnosis and earlier-stage intervention. MATERIALS AND METHODS: Out of the 72 cases in our institution, 40 cases with 18 F-FDG-PET/CT-negative MPM were retrospectively identified between 2007 and 2015...
September 2018: In Vivo
Florian Lenze, Chlodwig Kirchhoff, Florian Pohlig, Carolin Knebel, Hans Rechl, Birgit Marten-Mittag, Peter Herschbach, Rüdiger V Eisenhart-Rothe, Ulrich Lenze
BACKGROUND/AIM: Psycho-oncological distress is a relevant clinical problem. The aim of this study was to administer a standardized psycho-oncological distress screening for early identification and indication-based treatment of highly distressed orthopedic cancer patients as well as the evaluation of distress patterns. PATIENTS AND METHODS: In total, 35 patients with cancer were psycho-oncologically screened using a cancer-specific expert rating scale (Basic Documentation for Psycho-Oncology Short Form) at three different time points (day of admission, day before discharge, 3 months postoperatively)...
September 2018: In Vivo
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