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In Vivo

Syuhei Kushiyama, Katsunobu Sakurai, Naoshi Kubo, Yutaka Tamamori, Takafumi Nishii, Akiko Tachimori, Toru Inoue, Kiyoshi Maeda
BACKGROUND/AIM: The relationship between the preoperative Geriatric Nutritional Risk Index (GNRI) and morbidity of patients with gastric cancer (GC) undergoing gastrectomy has not yet been reported. Our study aimed to investigate whether preoperative GNRI is associated with short-term outcomes in elderly patients with GC. PATIENTS AND METHODS: This study enrolled 348 elderly patients with GC who were more than 75 years old and underwent curative gastrectomy for GC at our Institution between January 2006 and December 2015...
November 2018: In Vivo
Cecilia Bonolo DE Campos, Gleidice Eunice Lavalle, Lidianne Narducci Monteiro, Gabriela Rafaela Arantes Pêgas, Silvia Ligório Fialho, Débora Balabram, Geovanni Dantas Cassali
BACKGROUND/AIM: The aim of the present study was to evaluate a multimodal approach for the treatment of canine malignant mammary gland neoplasms, including surgery, chemotherapy, thalidomide, and metronomic chemotherapy (MC). MATERIALS AND METHODS: Fifty-eight female dogs were submitted to four different treatments: surgery; surgery with chemotherapy; surgery with chemotherapy and thalidomide; and surgery with chemotherapy and metronomic chemotherapy and overall survival was evaluated...
November 2018: In Vivo
Nazan Atalan, Leyla Acar, Nihan Yapici, Turkan Kudsioglu, Arzu Ergen, Seda Gulec Yilmaz, Turgay Isbir
BACKGROUND/AIM: Our aim was to determine serum TLR-9 levels in sepsis and evaluate the relationship between sepsis and serum TLR-9 levels. MATERIALS AND METHODS: The study group consisted of 80 consecutive patients with sepsis and 100 healthy individuals. The demographic characteristics, co-morbidities and hemodynamic data of all patients were recorded. RESULTS: TLR-9 serum levels in sepsis were statistically significantly lower compared to the control group...
November 2018: In Vivo
Vasilios C Constantinides, Maria Martha Papahatzaki, Georgios K Papadimas, Nikos Karandreas, Thomas Zambelis, Panagiotis Kokotis, Panagiota Manda
BACKGROUND/AIM: Diagnostic accuracy of muscle biopsy and electromyography (EMG) in patients with myopathy varies widely among studies. The goal of this study was to examine the diagnostic accuracy of each method in the diagnosis of patients with suspected myopathy, and determine the level of agreement between the two methods. PATIENTS AND METHODS: The files of all patients with a presumed myopathy were retrospectively reviewed. All patients with detailed muscle biopsy and EMG data were included...
November 2018: In Vivo
Satoshi Narihiro, Katsuhito Suwa, Takuro Ushigome, Masamichi Ohtsu, Syunjin Ryu, Yuya Shimoyama, Tomoyoshi Okamoto, Katsuhiko Yanaga
AIM: To retrospectively examine efficacy and safety of oral combination of trifluridine and tipiracil hydrochloride (TAS-102) as the second-line therapeutic agent for unresectable colorectal cancer. PATIENT AND METHODS: Treatment outcomes of 17 patients who had received TAS-102 at our Institution from January 2015 to January 2017 were analyzed. The indications for second-line TAS-102 treatment were intolerance to other multi-drug combination (four patients) or patient refusal of the standard second-line therapy (13 patients)...
November 2018: In Vivo
Jui-Hu Hsiao, Hong-Tai Chang, Yen-Dun Tseng, Chia-Ling Chiang, I-Shu Chen, Yu-Chia Chen, Po-Ming Chang, Being-Whey Wang
BACKGROUND: Patients with liver metastasis from breast cancer (LMBC) are usually offered systemic therapy. However, for those with progressive liver disease and limited extra-hepatic conditions, local liver management becomes an option. Herein we present our experience with hepatic arterial infusion chemotherapy (HAIC). PATIENTS AND METHODS: From 1999 to 2018, 42 patients with LMBC, who had progressive liver metastasis after systemic therapy, were treated with HAIC...
November 2018: In Vivo
Evdoxia Tsigkaropoulou, Athanasios Douzenis, Nikolaos Tsitas, Panagiotis Ferentinos, Ioannis Liappas, Ioannis Michopoulos
BACKGROUND/AIM: To evaluate psychometric properties of the Connor and Davidson Resilience Scale (CD-RISC) in a Greek population. MATERIALS AND METHODS: Internal consistency and test-retest reliability were measured. Global Assessment of Functioning Scale (GAF), World Health Organization Quality of Life (WHOQOL) questionnaire, Perceived Stress Scale (PSS) and General Health Questionnaire (GHQ) were used as measures for convergent reliability. Factors were extracted by using exploratory factor analysis (EFA)...
November 2018: In Vivo
Barbara Lattanzi, Peter Ott, Allan Rasmussen, Karen Raben Kudsk, Manuela Merli, Gerda Elisabeth Villadsen
BACKGROUND: Biliary complications (BC) are frequently observed following liver transplantation. The aim of the present retrospective study, conducted at an outpatients' tertiary care hospital, was to determine the incidence of biliary complications and risk factors associated with their development in liver transplantation (lT) patients. MATERIALS AND METHODS: The medical records were reviewed for all patients who underwent liver transplantation at the Rigshospitalet, Copenhagen, Denmark, from 2000 to 2011 and were referred to the Aarhus University Hospital for follow-up...
November 2018: In Vivo
Maria Schwab, Rainer Hofmann, Hendrik Heers, Axel Hegele
BACKGROUND/AIM: Since the advent of targeted therapeutics, paradigms in metastatic renal cell carcinoma (mRCC) treatment have changed. We investigated if efficacy and safety data from randomized controlled trials can be transferred into real-world settings. PATIENTS AND METHODS: All patients with mRCC treated from 2006-2015 at the Department of Urology (Marburg-Germany) were retrospectively analyzed. Collected data include: Patient demographics, tumor characteristics, efficacy, safety, and used therapy sequences...
November 2018: In Vivo
Ichiro Ogino, Masakazu Kitagawa, Shigenobu Watanabe, Hiroshi Yoshida, Masaharu Hata
BACKGROUND/AIM: Calcium phosphate cement (CPC) is used to fill bone voids in dental, orthopedic, and craniofacial applications. This study evaluated CPC marker as an injectable non-metallic fiducial marker. MATERIALS AND METHODS: Six patients received 3-5 injections of CPC paste placed at a depth of 10 mm into tumors of the cervix before treatment planning CT (TPCT). Patients were treated with external-beam radiotherapy (EBRT) and high-dose rate brachytherapy (BT)...
November 2018: In Vivo
Anda Militaru, Adina Avram, Anca Maria Cimpean, Mircea Iurciuc, Petru Matusz, Daniel Lighezan, Marius Militaru
Aim To assess the onset of early left ventricular (LV) systolic and diastolic function impairment and the subclinical atherosclerosis following chemotherapy in patients diagnosed with acute myeloid leukemia (AML). MATERIALS AND METHODS: Thirty patients diagnosed with AML with no cardiac history, having LV ejection fraction (LVEF) >50%, were evaluated at baseline and 6 months after starting four cycles of chemotherapy. We measured LV function, global longitudinal strain and subclinical atherosclerosis markers: intima-media thickness (IMT), arterial stiffness aortic pulse wave velocity (PWVAo) and ankle-brachial index (ABI)...
November 2018: In Vivo
Chun-Chi Lai, Shang-Yu Wang, Chien-Hung Liao, Jun-Te Hsu, Kun-Chun Chiang, Ta-Sen Yeh, Tsann-Long Hwang, Chun-Nan Yeh
BACKGROUND: For pancreatic ductal adenocarcinoma (PDAC), surgical margin status is an important pathological factor for evaluating surgical adequacy. In this study, we attempted to investigate predictive factors for the survival impact of positive surgical margins. MATERIALS AND METHODS: From February 2004 to December 2013, 204 patients were diagnosed with PDAC and underwent surgery with radical intent; 189 patients fulfilled our selection criteria and were enrolled for analysis...
November 2018: In Vivo
Hironori Yoshida, Young Hak Kim, Hiroaki Ozasa, Yuichi Sakamori, Takahiro Tsuji, Takashi Nomizo, Yuto Yasuda, Tomoko Yamamoto, Hitomi Ajimizu, Toyohiro Hirai
BACKGROUND: Alectinib is a new standard treatment for treatment-naïve anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC); however, resistance ultimately develops in almost all patients, and data regarding the efficiency of ceritinib for such patients are insufficient. PATIENTS AND METHODS: Patients with ALK-positive NSCLC treated at the Kyoto University Hospital from January 2012 to March 2017 were reviewed. Patients who were treated with ceritinib after alectinib were identified, and the efficacy of ceritinib after alectinib was retrospectively evaluated...
November 2018: In Vivo
Hiroshige Yoshioka, Yoshihito Kogure, Masahiko Ando, Chiyoe Kitagawa, Masahiro Iwasaku, Takashi Niwa, Hideo Saka
BACKGROUND: Amrubicin hydrochloride is administered as second- or third-line therapy for small cell lung cancer, and is known to cause severe myelotoxicity. This study evaluated the efficacy and safety of weekly amrubicin for refractory/relapsed small cell lung cancer. PATIENTS AND METHODS: A single-arm, open-label, multicenter, phase II study of weekly amrubicin was performed in 21 patients at seven centers in Japan from 2012 through 2015. RESULTS: A partial response (PR) was noted in one out of the first 18 patients...
November 2018: In Vivo
Rolandas Zablockis, Edvardas Žurauskas, Edvardas Danila, Vygantas Gruslys
BACKGROUND/AIM: The prognostic role of thyroid transcription factor-1 (TTF1) in advanced lung cancer is not clearly established. The present study aimed to evaluate the associations between clinicopathological characteristics, TTF1 expression, and overall survival (OS) of patients with advanced lung adenocarcinoma. MATERIALS AND METHODS: One hundred and seventy-two patients were enrolled in this retrospective study. OS was assessed according to immunohistochemical TTF1 expression in lung adenocarcinoma tissue, age, gender, performance status (PS), smoking history and status, disease stage, tumor differentiation, epidermal growth factor receptor (EGFR) mutation and EGFR tyrosine kinase inhibitor (TKI) treatment status...
November 2018: In Vivo
Heejae Lee, Hee Jin Lee, In Hye Song, Won Seon Bang, Sun-Hee Heo, Gyungyub Gong, In Ah Park
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs) are prognostic markers in triple-negative breast cancer (TNBC). Our study analyzed the relationship between cluster of differentiation (CD)11c-positive dendritic cells (DCs) and TILs and TLSs to elucidate mechanisms of TIL influx. MATERIALS AND METHODS: Immunohistochemical staining for CD4, CD8, and CD11c in tissue microarrays from 681 patients with TNBC was performed. The proportions of TILs and TLSs were reviewed...
November 2018: In Vivo
Balázs Németh, István Kiss, Bella Ajtay, Iván Péter, Zita Kreska, Attila Cziráki, Iván G Horváth, Zénó Ajtay
AIM: We aimed to investigate the effects of a single carbon dioxide (CO2 ) treatment on arterial stiffness by monitoring the changes of aortic pulse-wave velocity (PWV) and aortic augmentation index (AIXao), which are indicators of arterial stiffness. PATIENTS AND METHODS: PWV and AIXao were measured by an invasively validated oscillometric device. The measurements of stiffness parameters were performed before the CO2 treatment, and at 1, 4 and 8 h after the first treatment...
November 2018: In Vivo
Sarka Svobodova, Marie Karlikova, Ondrej Topolcan, Ladislav Pecen, Martina Pestova, Otto Kott, Vladislav Treska, David Slouka, Radek Kucera
AIM: The aim of this study was to evaluate the clinical contribution of protein induced by vitamin K absence (PIVKA-II) for hepatocellular carcinoma (HCC) diagnostics and compare it with alpha-foetoprotein (AFP), a routinely used tumour marker. MATERIALS AND METHODS: A total of 332 participants were enrolled in this study: 64 with HCC, 48 with liver metastases of colorectal cancer origin, 42 with liver cirrhosis and 178 healthy individuals. Serum levels of PIVKA-II were measured using the chemiluminescent assay of the Architect 1000i System (Abbott, USA) and AFP levels using the chemiluminescent assay by DxI 800 (Beckman Coulter, USA)...
November 2018: In Vivo
Kazuki Takada, Gouji Toyokawa, Koichi Azuma, Shinkichi Takamori, Tomoko Jogo, Fumihiko Hirai, Tetsuzo Tagawa, Akihiko Kawahara, Jun Akiba, Isamu Okamoto, Yoichi Nakanishi, Yoshinao Oda, Tomoaki Hoshino, Yoshihiko Maehara
AIM: Programmed cell death-ligand 1 and 2 (PD-L1 and PD-L2) are ligands of the programmed cell death-1 (PD1) receptor. PD1/PD-L1 inhibitors have shown clinical efficacy in non-small cell lung cancer (NSCLC). However, relatively little is known about the expression of PD-L2, or its association with the clinicopathological features of NSCLC. Here, the radiological features of PD-L2-positive lung adenocarcinoma were evaluated. MATERIALS AND METHODS: PD-L1 and PD-L2 expression were evaluated by immunohistochemical staining of surgically-resected specimens from 393 patients with primary lung adenocarcinoma who underwent preoperative thin-section computed tomography (CT), 222 of whom also underwent 18 F-fluorodeoxyglucose positron-emission tomography/CT (18 F-FDG-PET/CT)...
November 2018: In Vivo
Chih-Po Hsu, Li-Yu Lee, Jun-Te Hsu, Yu-Pao Hsu, Yu-Tung Wu, Shang-Yu Wang, Chun-Nan Yeh, Tse-Ching Chen, Tsann-Long Hwang
BACKGROUND/AIM: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive types of digestive cancer. Recurrence within one year after surgery is inevitable in most PDAC patients. Recently, cluster of differentiation 44 (CD44) has been shown to be associated with tumor initiation, metastasis and prognosis. This study aimed to explore the correlation of CD44 expression with clinicopathological factors and the role of CD44 in predicting early recurrence (ER) in PDAC patients after radical surgery...
November 2018: In Vivo
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