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In Vivo

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https://www.readbyqxmd.com/read/28882979/multiple-sclerosis-and-subsequent-human-immunodeficiency-virus-infection-a-case-with-the-rare-comorbidity-focus-on-novel-treatment-issues-and-review-of-the-literature
#1
Charalampos Skarlis, Maria Gontika, Serafeim Katsavos, Giorgios Velonakis, Panagiotis Toulas, Maria Anagnostouli
BACKGROUND: The comorbidity between Multiple Sclerosis (MS) and Human Immunodeficiency Virus (HIV) infection is particularly rare. Only a few cases of comorbidity of Clinically Definite(CD)-MS and HIV have been documented worldwide, while the potential beneficial role of antiretroviral therapy regarding MS activity has long been an area of debate. CASE REPORT: We present a 36-year old male, bearing a diagnosis of CD-MS for twelve years. He had been treated for ten years with interferon-beta-1b, when he voluntarily discontinued therapy, claiming clinical stability...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882978/predictive-factors-of-nivolumab-induced-hypothyroidism-in-patients-with-non-small-cell-lung-cancer
#2
Toshiya Maekura, Maiko Naito, Masahiro Tahara, Naoya Ikegami, Yohei Kimura, Shoko Sonobe, Takehiko Kobayashi, Taisuke Tsuji, Shojiro Minomo, Akihiro Tamiya, Shinji Atagi
BACKGROUND/AIM: Although immune checkpoint inhibitors play an important role in the therapy of lung cancer, they are associated with various immune-related adverse events and predictive factors of them are unclear. In this study, we investigated predictive factors of nivolumab-induced hypothyroidism which is one of the adverse events in patients with lung cancer. PATIENTS AND METHODS: Patients with non-small-cell lung cancer who were administered nivolumab at our hospital between December 2015 and May 2016 were retrospectively enrolled...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882977/influence-of-diabetes-on-circulating-apoptotic-microparticles-in-patients-with-chronic-hepatitis-c
#3
Jolanta Zuwala-Jagiello, Monika Pazgan-Simon, Eugenia Murawska-Cialowicz, Krzysztof Simon
BACKGROUND/AIM: Type 2 diabetes mellitus (DM) frequently occurs in patients with chronic hepatitis C (CHC) and is associated with atherosclerosis, in which circulating microparticles (MPs) play an important role. We asked whether the presence of DM affects endothelial-derived (EMPs) and platelet-derived microparticles (PMPs) levels; and whether MPs levels associate with biomarkers of inflammation and oxidative stress in patients with CHC. MATERIALS AND METHODS: Overall, 136 patients were enrolled in the study, 86 CHC patients (41 with DM with moderate glycemic control), 20 outpatients with DM and 30 controls...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882976/endobronchial-carcinoid-tumor-totally-occluding-the-left-main-bronchus-without-producing-symptoms-of-bronchial-obstruction
#4
Diamantis I Tsilimigras, Demetrios Moris, Ioannis Ntanasis-Stathopoulos, Davide Patrini, Nikolaos Panagiotopoulos
BACKGROUND: Bronchial carcinoid tumors (BCTs) are rare neuroendocrine neoplasms of the lung that mainly have a central distribution. They are classified as typical and atypical, with the former variant generally conferring a more favorable survival. Central tumors are usually symptomatic with features of bronchial obstruction, whereas peripheral tumors may remain silent. CASE REPORT: A 36-year-old woman presented to our hospital due to an episode of massive hemoptysis 5 days prior to admission...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882975/gastric-tube-reconstruction-with-superdrainage-using-indocyanine-green-fluorescence-during-esophagectomy
#5
Hiroyuki Kitagawa, Tsutomu Namikawa, Jun Iwabu, Kazuhiro Hanazaki
We report a case of gastric tube reconstruction with superdrainage using indocyanine green fluorescence during esophagectomy for esophageal cancer. A 53-year-old man with a history of early esophageal cancer treated with endoscopic mucosal dissection experienced esophageal cancer recurrence. There was no evidence of lymph node involvement or distant metastasis on computed tomography; therefore, we performed thoracoscopic esophagectomy. After thoracoscopic esophagectomy, we created a gastric tube. When pulling up the gastric tube through the post-mediastinum route, a root of the right gastroepiploic vein was injured...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882974/lymph-node-size-on-computed-tomography-images-is-a-predictive-indicator-for-lymph-node-metastasis-in-patients-with-colorectal-neuroendocrine-tumors
#6
Toshiaki Tanaka, Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Tomomichi Kiyomatsu, Takeshi Nishikawa, Kensuke Otani, Kazuhito Sasaki, Koji Murono, Toshiaki Watanabe
BACKGROUND: Colorectal neuroendocrine tumors (NET) are a rare manifestation of colorectal neoplasia, requiring for radical dissection of the regional lymph nodes along with colorectal resection similar to that required for colorectal cancer. However, thus far, no reports have described the ability of computed tomography (CT) to predict lymph node involvement. In this study, we revealed the prediction rate of lymph node metastasis using contrast-enhanced CT. PATIENTS AND METHODS: A total of 21 patients with colorectal NET undergoing colorectal resection were recruited from January 2010 to June 2016...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882973/elevated-serum-aa-epa-ratio-as-a-predictor-of-skeletal-muscle-depletion-in-cachexic-patients-with-advanced-gastro-intestinal-cancers
#7
Moeko Kitagawa, Seiji Haji, Teruyoshi Amagai
BACKGROUND: In recent years, the number of cancer patients has increased. Cancer patients are prone to sarcopenia as a result of the decrease in muscle mass and muscle weakness which occurs in cancer cachexia. Attention has been given on the effects of fatty acid administration on cancer patients. MATERIALS AND METHODS: We conducted a retrospective chart-review study of consecutive patients with unresectable advanced GI cancer (stage IV) (n=46) receiving chemotherapy treatment in an outpatient or in-hospital setting between December 2012 and September 2015 at our Institution...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882972/ileocecal-obstruction-due-to-endometriosis-a-case-report-and-literature-review
#8
Nicolae Bacalbasa, Irina Balescu, Alexandru Filipescu
Endometriosis is a common finding in premenopausal women and a significant number of cases presenting digestive tract involvement at the time of diagnosis. However, most of these patients present pelvic nodules involving the rectosigmoidian junction, other digestive tract segments being less commonly affected. We present the case of a 37-year-old nulliparous woman who presented for diffuse abdominal pain and vomiting; she was diagnosed with complete ileocecal obstruction due to an endometriosis nodule in association with bilateral ovarian endometriosis lesions invading the rectosigmodian wall...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882971/mouse-hemokinin-1-decapeptide-subjected-to-a-brain-specific-post-translational-modification
#9
Georgia Deliconstantinos, Stephen Barton, Mikhail Soloviev, Nigel Page
BACKGROUND/AIM: The tachykinin mouse hemokinin-1, expressed by the mouse Tac4 gene, produces either analgesia or nociception, interacting with the neurokinin 1 receptor. TAC4 precursor processing is not identical to the processing of the TAC1 precursor, for the release of substance P (amidated undecapeptide). The characterization of the mouse hemokinin-1 sequence was required. MATERIALS AND METHODS: We developed anti-tachykinin-specific antibodies for the immunoaffinity purification of tachykinins...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882970/management-of-a-fulminant-upper-gastrointestinal-bleeding-exteriorized-through-hemobilia-due-to-arteriobiliary-fistula-between-the-common-bile-duct-and-a-right-hepatic-artery-aneurysm-a-case-report
#10
Nicolae Bacalbasa, Iulian Brezean, Claudiu Anghel, Ion Barbu, Mihai Pautov, Irina Balescu, Vladislav Brasoveanu
Right hepatic artery aneurysms are rare events that might remain asymptomatic for a long period of time. However, in cases presenting large lesions, symptoms might develop especially due to the association of compression of the surrounding elements. Most often these symptoms and signs include diffuse abdominal pain, jaundice or portal vein compression signs. In rare cases life-threatening complications might develop due to the aneurysmal erosion of the biliary duct, portal vein or due to the aneurysmal rupture in the peritoneal cavity...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882969/successful-resection-and-vascular-ligation-of-a-large-hepatic-artery-aneurysm-a-case-report-and-literature-review
#11
Nicolae Bacalbasa, Iulian Brezean, Claudiu Anghel, Ion Barbu, Mihai Pautov, Irina Balescu, Vladislav Brasoveanu
The occurrence of hepatic artery aneurysms is rare and might be incidentally diagnosed, as the patient remains asymptomatic for a long period of time. However, due to the fact that these lesions are associated with a high risk of developing life threatening complications, such as intraperitoneal rupture, it has been stated that all cases should be submitted to treatment by endovascular or surgical approach. We present the case of a 68-year-old patient, who presented with recurrent upper digestive tract bleedings and was diagnosed with a large aneurysm of the common and the proper hepatic artery, and the gastroduodenal artery...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882968/rectosigmoidian-involvement-in-advanced-stage-ovarian-cancer-intraoperative-decisions
#12
Nicolae Bacalbasa, Irina Balescu, Simona Dima
BACKGROUND/AIM: Ovarian cancer remains one of the most commonly encountered malignancies affecting women worldwide, that is unfortunately commonly diagnosed in advanced stages of the disease. In these stages, the tumoral process usually involves the surrounding viscera throughout contiguity or induces the apparition of distant metastases via peritoneal, lymphatic or hematogenous spread, multiple resections being needed in order to achieve a good control of the disease. PATIENTS AND METHODS: In the present study, we present a case series of 12 patients in whom various surgical procedures on the rectosigmoidian loop were performed in order to achieve debulking surgery to no residual disease...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882967/influenza-among-breast-cancer-survivors-in-south-korea-a-nationwide-population-based-study
#13
Jaesung Heo, Mison Chun, Young-Taek Oh, O Kyu Noh, Logyoung Kim
BACKGROUND/AIM: In this study, we analyzed the prevalence of influenza disease in breast cancer survivors using claims data from the Health Insurance Review and Assessment Service (HIRA) in South Korea. PATIENTS AND METHODS: We defined influenza among a nationwide cohort of 87,843 patients who were diagnosed with breast cancer and underwent surgery from January 1, 2010 to December 31, 2014, based on HIRA claim data. Descriptive statistics were calculated to estimate the frequency of influenza disease using diagnostic code and utilization pattern at medical institutions...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882966/predictive-factors-of-late-onset-rectal-mucosal-changes-after-radiotherapy-of-prostate-cancer
#14
Edy Ippolito, Alessandra Guido, Gabriella Macchia, Francesco Deodato, Lucia Giaccherini, Andrea Farioli, Alessandra Arcelli, Dajana Cuicchi, Leonardo Frazzoni, Savino Cilla, Milly Buwenge, Giovanna Mantini, Anna R Alitto, Marianna Nuzzo, Vincenzo Valentini, Marcello Ingrosso, Alessio G Morganti, Lorenzo Fuccio
BACKGROUND/AIM: The Vienna Rectoscopy Score (VRS; from 0, absence of rectal mucosal changes, to 5) assessed 1 year after radiotherapy is a surrogate end-point of late rectal toxicity. The aim of this study was to investigate the association between treatment-related factors and 1-year VRS. PATIENTS AND METHODS: We performed a retrospective analysis of prospectively collected data. Patients with prostate adenocarcinoma treated with definitive or postoperative radiotherapy (RT) underwent endoscopy 1 year after RT...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882965/rotating-gamma-system-irradiation-a-promising-treatment-for-low-grade-brainstem-gliomas
#15
Pham Cam Phuong, Nguyen Quang Hung, Tran Bao Ngoc, Dirk Rades, Mai Trong Khoa
AIM: To evaluate the role of rotating gamma system (RGS) radiosurgery for low-grade brainstem gliomas. PATIENTS AND METHODS: Thirty-seven patients undergoing RGS radiosurgery at the Bach Mai Hospital Hanoi for low-grade brainstem glioma were included in this prospective interventional study. The median RGS dose was 12 Gy (range=8-16 Gy). Endpoints included response to RGS radiosurgery given as change in glioma size (maximum diameter), survival and adverse events...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882964/impact-of-time-factors-on-outcome-in-patients-with-head-and-neck-cancer-treated-with-definitive-radio-chemo-therapy
#16
Sören Dahlke, Diana Steinmann, Hans Christiansen, Martin Durisin, Andre Eckardt, Gerd Wegener, Michael Bremer, Andreas Meyer
AIM: To evaluate treatment-related factors such as overall treatment time (OTT) and radiation treatment time (RTT) in head-and-neck cancer. PATIENTS AND METHODS: A total of 216 patients with locoregionally advanced inoperable head and neck cancer were treated with definitive radio(chemo)therapy. Mean follow-up was 37 months. RESULTS: Median time from diagnosis to start of radiotherapy (total waiting time) was 34 days, and comprised of referral waiting time and time for preparatory work...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882963/risk-factors-for-transumbilical-wound-complications-in-laparoscopic-gastric-and-colorectal-surgery
#17
Kodai Tomioka, Masahiko Murakami, Akira Fujimori, Makoto Watanabe, Tomotake Koizumi, Satoru Goto, Koji Otsuka, Takeshi Aoki
AIM: To investigate the risk factors of transumbilical incision for organ removal in laparoscopic surgery. PATIENTS AND METHODS: We enrolled 643 consecutive patients undergoing laparoscopic surgery from 2010 to 2013. Superficial surgical site infection (SSI) and transumbilical port site hernia were recorded. RESULTS: The participants underwent gastric (n=253) and colorectal (n=390) resections. SSI was observed in 17 cases (colorectal in 15; gastric in two) (2...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882962/prospective-analysis-of-a-sterile-semi-automated-tissue-biopsy-homogenization-method-in-the-diagnosis-of-prosthetic-joint-infections
#18
Christian Suren, Norbert Harrasser, Florian Pohlig, Ingo J Banke, Ulrich Lenze, Florian Lenze, Carolin Knebel, Rüdiger VON Eisenhart-Rothe, Johannes Schauwecker, Heinrich M L Mühlhofer
BACKGROUND/AIM: Prosthetic joint infection (PJI) remains a serious complication of total joint arthroplasty. To effectively treat PJI, it is essential to identify the microorganism causing it and be able to combine correct surgical and anti-infective treatments. This cannot always be achieved with the currently employed diagnostic methods. The aim of this study was to evaluate a semi-automated tissue biopsy bead milling method (Ultra-TurrAX, Axonlab AG; Reichenbach, Germany) based on the hypothesis that the results are more sensitive for microbe detection and less prone to contamination...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882961/efficacy-of-n-acetylcysteine-d-mannose-and-morinda-citrifolia-to-treat-recurrent-cystitis-in-breast-cancer-survivals
#19
Debora Marchiori, Pier Paolo Zanello
BACKGROUND/AIM: Breast cancer survivors in adjuvant therapy, frequently experience the estrogen deficiency with genitourinary symptoms mostly represented by recurrent bacterial cystitis. The objective of the present study was to evaluate the effectiveness of N-acetylcysteine, D-mannose and Morinda citrifolia fruit extract (NDM), when associated to antibiotic therapy, in reducing the persistence of recurrent cystitis in this risk population. PATIENTS AND METHODS: Sixty breast cancer survived women with recurrent cystitis were retrospectively examined...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882960/parathyroid-carcinoma-in-patients-that-have-undergone-surgery-for-primary-hyperparathyroidism
#20
Petr Libánský, Svatopluk Adámek, Petr Broulík, Martina Fialová, Josef Kubinyi, Robert Lischke, Ondřej Naňka, Pavel Pafko, Jiří Šedý, Vladimír Bobek
BACKGROUND/AIM: Parathyroid carcinoma is a rare clinical entity, which represents one of the main reasons, why surgery should be performed in specialized centres. Preoperatively, it is very difficult to distinguish between benign and malignant hyperparathyroidism. PATIENTS AND METHODS: During the years 1996-2016, we performed 2,220 operations in 2,075 patients with a diagnosis of primary hyperparathyroidism. RESULTS: Among these 2,220 operations, there were 16 operations for parathyroid carcinoma...
September 2017: In Vivo
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