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In Vivo

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https://www.readbyqxmd.com/read/29475935/prognostic-impact-of-inflammation-related-biomarkers-on-overall-survival-of-patients-with-inoperable-malignant-pleural-mesothelioma
#1
Takehiro Otoshi, Yuki Kataoka, Sawako Kaku, Reika Iki, Masataka Hirabayashi
AIM: The aim of the present study was to assess the prognostic utility of the pretreatment blood neutrophil-to-lymphocyte ratio (NLR) and the C-reactive protein-to-albumin ratio (CAR) in patients with inoperable malignant pleural mesothelioma (MPM). MATERIALS AND METHODS: The medical records of consecutive patients with histologically confirmed MPM from our hospital between January 2007 and August 2017 were retrospectively reviewed. The primary outcome was overall survival (OS)...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475934/-in-vivo-scanning-laser-confocal-microscopy-of-conjunctival-goblet-cells-in-medically-controlled-glaucoma
#2
Silvio DI Staso, Luca Agnifili, Marco Ciancaglini, Gianluca Murano, Enrico Borrelli, Leonardo Mastropasqua
AIM: The aim of this study was to evaluate the goblet cell density (GCD) of conjunctiva in medically-controlled glaucoma using laser scanning confocal microscopy (LSCM). MATERIALS AND METHODS: Fifty-five glaucomatous patients were enrolled and divided into two groups: Group 1 (27 eyes), controlled with one medication; and group 2 (28 eyes), controlled with two medications. Seventeen patients with dry eye disease (DED) and 17 healthy individuals served as controls...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475933/association-of-diaphragmatic-surgery-as-part-of-cytoreductive-effort-in-advanced-stage-ovarian-cancer
#3
Nicolae Bacalbasa, Irina Balescu, Cristian Balalau, Olivia Ionescu, Claudia Stoica
BACKGROUND/AIM: Diaphragmatic surgery in advanced-stage ovarian cancer has been considered since long time to increase the rates of postoperative complications. However, improvement of surgical techniques and perioperative management of these patients has lead in the last decade to a safe association of such procedures as part of debulking process. The aim of the current paper was to report our experience regarding the role of diaphragmatic resections as part of debulking surgery for advanced stage ovarian cancer...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475932/differences-in-urinary-amino-acid-patterns-in-individuals-with-different-types-of-urological-tumor-urinary-amino-acid-patterns-as-markers-of-urological-tumors
#4
Katerina Duskova, Stepan Vesely, Joana DO Carmo Silva, Natalia Cernei, Ondrej Zitka, Zbynek Heger, Vojtech Adam, Klara Havlova, Marek Babjuk
BACKGROUND: Insufficient specificity and invasiveness of currently used diagnostic methods raises the need for new markers of urological tumors. The aim of this study was to find a link between the urinary excretion of amino acids and the presence of urological tumors. MATERIALS AND METHODS: Using ion-exchange chromatography, we tested urine samples of patients with prostate cancer (n=30), urinary bladder cancer (n=28), renal cell carcinoma (n=16) and healthy volunteers (control group; n=21)...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475931/the-influence-of-cardiac-pacemaker-programming-modes-on-exercise-capacity
#5
Bogdan Caloian, Adela Viviana Sitar-Taut, Gabriel Nicolae Gusetu, Dana Pop, Dumitru Tudor Zdrenghea
BACKGROUND/AIM: The cardiac pacing mode influences the atrioventricular synchronicity and the response of the heart rate to physical exercise. The aim of this study was to compare the influence of the most common pacemaker programming modes on exercise capacity. PATIENTS AND METHODS: Fifty-two pacemaker-wearing patients were clinically evaluated and submitted to an exercise stress test. RESULTS: Symptoms of heart failure were more frequently met in the single-chamber pacemaker group compared to the dual-chamber group...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475930/primary-gastric-ebv-positive-diffuse-large-b-cell-lymphoma-dlbcl-of-the-elderly-with-plasmablastic-differentiation
#6
Ming Hu, Jose Trevino, Lijun Yang, Dengfeng Cao, Xiuli Liu, Jinping Lai
Epstein-Barr virus (EBV)-positive diffuse large B cell lymphoma (DLBCL) of the elderly is a rare subtype of B-cell neoplasms. Primary gastric EBV-positive DLBCL of the elderly with partial plasmablastic phenotype is extremely rare. Differentiation of EBV-positive DLBCL of the elderly with partial plasmablastic phenotype from true plasmablastic lymphoma (PBL) is difficult and very important from the therapeutic and prognostic point of view. Here we report a case of a 59-year-old man with upper gastrointestinal bleeding...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475929/effect-of-androgen-deprivation-therapy-on-bone-mineral-density-in-japanese-patients-with-prostate-cancer
#7
Yoshiyuki Miyazawa, Yoshitaka Sekine, Takahiro Syuto, Masashi Nomura, Hidekazu Koike, Hiroshi Matsui, Yasuhiro Shibata, Kazuto Ito, Kazuhiro Suzuki
BACKGROUND/AIM: To evaluate bone mineral density (BMD) in Japanese patients with prostate cancer (PCa) after administering androgen deprivation therapy (ADT) for 2 years. PATIENTS AND METHODS: A total of 84 Japanese patients with PCa were enrolled in this study during the period 2008-2011. BMD was measured by dual energy X-ray absorptiometry, every 6 months. The fracture risk assessment tool (FRAX) score was calculated before starting ADT. We evaluated the change in BMD over a 2-year period and the relationship between this change, the FRAX score, and the estimated glomerular filtration rate (eGFR)...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475928/tear-film-osmolarity-in-subjects-with-acute-allergic-rhinoconjunctivitis
#8
Eirini Nitoda, Anastasios Lavaris, Konstantinos Laios, Sophia Androudi, Chris D Kalogeropoulos, Michael Tsatsos, Christos Damaskos, Nikolaos Garmpis, Marilita M Moschos
BACKGROUND/AIM: Acute allergic rhinoconjuctivitis is the most common form of ocular allergies. The pathogenetic mechanisms are based on an immunoglobulin E (IgE)-mediated hypersensitivity reaction. On the other hand, tear osmolarity has been suggested to be an index of ocular surface damage and inflammation. These data were the motive to investigate the levels of tear osmolarity in subjects with acute allergic rhinoconjuctivitis, before and after administration of artificial tears. PATIENTS AND METHODS: Forty-five subjects with acute allergic rhinoconjuctivitis were randomly divided into three groups, based on the type of artificial tears that they received: Group A (Thera tears), Group B (Wet therapy) and Group C (Tears Naturale free)...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475927/increase-in-serum-amylase-and-resistive-index-after-kidney-transplant-are-biomarkers-of-delayed-graft-function
#9
Giorgia Comai, Olga Baraldi, Vania Cuna, Valeria Corradetti, Andrea Angeletti, Seidju Brunilda, Irene Capelli, Maria Cappuccilli, Gaetano LA Manna
BACKGROUND: Both amylase and resistive index (RI) are routinely measured after kidney transplant and proposed as markers of delayed graft function (DGF). MATERIAL AND METHODS: This retrospective cross-sectional study analyzed amylase and RI in 269 renal transplant recipients before and after transplantation, and at discharge. An increase above 20% of total amylase with/without RI>0.7 were evaluated as prognostic markers of DGF, hospitalization length and risk of rejection...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475926/cullin-1-and-2-protein-expression-in-colorectal-cancer-correlation-with-clinicopathological-variables
#10
Othon Michail, Demetrios Moris, Stamatios Theocharis, John Griniatsos
BACKGROUND/AIM: The cullin (CUL) family of proteins is involved in the ubiquitin/mediated degradation of proteins, regulating cell proliferation, cell-cycle control, migration, invasion and metastasis in the process of tumor progression. The aim of the present study was to examine if there is any correlation between the immunohistochemical (IHC) expression of Cullin-1 and -2 proteins in colorectal cancer tissue specimens with several clinicopathological variables. MATERIALS AND METHODS: Between January 2012 and December 2014, 96 consecutive adenocarcinoma patients were submitted to oncological colectomy, as the first therapeutic option, with a curative intent...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475925/normal-size-ovary-carcinoma-syndrome-with-inguinal-ovarian-cancer-lymph-node-metastases-a-case-report-and-literature-review
#11
Nicolae Bacalbasa, Irina Balescu, Cristian Balalau, Olivia Ionescu, Claudia Stoica
Inguinal lymph node mass as the first sign in patients with ovarian cancer represents a rare situation, with only few cases being reported so far. We present the case of a 46-year-old patient who presented for the apparition of bilateral inguinal tumoral masses in the absence of any other pathological signs. The biopsy revealed the presence of an adenocarcinoma with probable genital origin; however, neither the gynaecological examination nor the computed tomography demonstrated the presence of any suspect lesion...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475924/validation-of-a-survival-score-for-patients-receiving-radiosurgery-or-fractionated-stereotactic-radiotherapy-for-1-to-3-brain-metastases
#12
Dirk Rades, Oliver Blanck, Mai Trong Khoa, Pham VAN Thai, Nguyen Quang Hung, Liesa Dziggel, Steven E Schild
BACKGROUND/AIM: We developed a scoring system to predict 1-year survival after radiosurgery for 1-3 brain metastases. This study aimed to validate this system. PATIENTS AND METHODS: Seventy-six new patients were included in this validation study. Like in the original scoring-system, three factors (age, performance status, extra-cranial metastases) were used. For each factor, 1-year survival rates in % were divided by 10, and the three scoring-points were added for each patient...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475923/determinants-of-survival-after-emergency-intrapericardial-cisplatin-treatment-in-cancer-patients-with-recurrent-hemodynamic-instability-after-pericardiocentesis
#13
Szymon Darocha, Michał Wilk, Anna Walaszkowska-Czyż, Jarosław Kępski, Rafał Mańczak, Marcin Kurzyna, Adam Torbicki, Sebastian Szmit
BACKGROUND: Pericardial effusion is associated with high mortality in oncology. The etiology of infectious pericarditis and iatrogenic effects of previous radio-/chemotherapy may be always suspected, especially when a subsequent episode is observed. PATIENTS AND METHODS: The study included 17 hemodynamically-unstable patients with cancer due to recurrent pericardial bloody effusion after previous pericardiocentesis and analyzed survival determinants after intrapericardial chemotherapy with cisplatin...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475922/dclk1-expression-in-colorectal-polyps-increases-with-the-severity-of-dysplasia
#14
Aki Takiyama, Toshiaki Tanaka, Shinsuke Kazama, Hiroshi Nagata, Kazushige Kawai, Keisuke Hata, Kensuke Otani, Takeshi Nishikawa, Kazuhito Sasaki, Manabu Kaneko, Shigenobu Emoto, Koji Murono, Hirotoshi Takiyama, Hiroaki Nozawa
BACKGROUND: The expression of doublecortin-like kinase 1 (DCLK1) has been investigated in cancer; however not in precancerous adenomatous polyps. MATERIALS AND METHODS: Immunohistological expression of DCLK1 was evaluated in various grades of adenomas, cancerous polyps, and hyperplastic polyps in resected human tissue specimens. RESULTS: Ninety-two specimens were positive for DCLK1 and 134 were negative. Cancerous polyps showed a high DCLK1 positivity rate compared to adenomas (68...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475921/clinical-impact-of-a-surgical-energy-device-in-advanced-ovarian-cancer-surgery-including-bowel-resection
#15
Giuseppe Vizzielli, Carmine Conte, Massimo Romano, Anna Fagotti, Barbara Costantini, Claudio Lodoli, Salvatore Gueli Alletti, Khaled Gaballah, Fabio Pacelli, Alfredo Ercoli, Giovanni Scambia, Valerio Gallotta
AIM: To evaluate the clinical impact of the use of the Caiman® articulating energy device in advanced ovarian cancer (AOC) including rectosigmoid resection [e.g. modified posterior exenteration (MPE)]. PATIENTS AND METHODS: This was a prospective single-institution observational study with women undergoing MPE where all soft-tissue dissections and vessel ligations were performed using the Caiman® device. Intraoperative and postoperative surgical data were collected...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475920/the-difference-in-prognostic-outcomes-between-de-novo-stage-iv-and-recurrent-metastatic-patients-with-hormone-receptor-positive-her2-negative-breast-cancer
#16
Jun Yamamura, Shunji Kamigaki, Junya Fujita, Hiroki Osato, Yoshifumi Komoike
BACKGROUND/AIM: Patients with de novo stage IV and recurrent metastatic breast cancer are often treated with the same strategies, although the difference in prognostic outcomes remains unclear. The objective of this retrospective chart review study was to compare the prognostic outcomes between two types of patients with hormone receptor-positive (HR+), HER2-negative (HER2-) breast cancer. PATIENTS AND METHODS: We estimated overall survival of the two groups and evaluated the progressive course of the disease using disease-free interval (DFI) and interval from the end of adjuvant treatment to the first recurrence (AFI)...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475919/thyrotoxicosis-and-adrenocortical-hormone-deficiency-during-immune-checkpoint-inhibitor-treatment-for-malignant-melanoma
#17
Hiroyuki Ariyasu, Hidefumi Inaba, Takayuki Ota, Hiroyuki Yamaoka, Yasushi Furukawa, Hiroshi Iwakura, Naotaka Doi, Yuki Yamamoto, Takashi Akamizu
BACKGROUND: Immune-checkpoint inhibitors (ICIs) are novel promising agents for the treatment of malignant tumors. However, critical endocrine immune-related adverse events (irAEs) by ICIs often occur. CASE REPORT: A 63-year-old woman with advanced malignant melanoma had received anti-PD-1 antibody (nivolumab, 2 mg/kg every 3 weeks) for 8 cycles (from day 0 to day 147). On day 168, nivolumab was switched to anti-CTLA-4 antibody (ipilimumab, 3mg/kg every 3 weeks)...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475918/pulmonary-tumor-embolism-due-to-squamous-cell-carcinoma-of-the-uterine-cervix-a-case-report
#18
Shohei Okazaki, Takanori Abe, Natsuko Takayanagi, Masanori Yasuda, Fumikazu Sakai, Kunihiko Kobayashi, Shingo Kato
BACKGROUND/AIM: We report on a case of pulmonary tumor embolism caused by squamous cell carcinoma of the uterine cervix. PATIENTS AND METHODS: A 60-year-old female diagnosed with stage IVB (cT4N1M1) squamous cell carcinoma of the uterine cervix was admitted to our institution with a chief complaint of progressive dyspnea that developed within a few days after admission. RESULTS: A chest CT scan showed dilated pulmonary arteries, right ventricular enlargement and mosaic ground-glass opacities in both lungs...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475917/how-should-palliative-thoracic-radiotherapy-be-fractionated-for-octogenarians-with-lung-cancer
#19
Carsten Nieder, Rosalba Yobuta, Bård Mannsåker, Astrid Dalhaug
BACKGROUND/AIM: Geriatric oncology practice should be based on dedicated studies and real-world experience. Therefore, we evaluated survival outcomes after palliative thoracic radiotherapy in octogenarian patients with lung cancer and analyzed prognostic factors. PATIENTS AND METHODS: We carried out a retrospective analysis of 51 patients with a median age of 83 years. Three different fractionation regimens were compared: two fractions of 8.5 Gy, 10 fractions of 3 Gy, and higher doses than 30 Gy (maximum biologically equivalent dose in 2-Gy fractions (EQD2) was always lower than 50 Gy)...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29475916/does-marital-status-influence-levels-of-anxiety-and-depression-before-palliative-radiotherapy
#20
Carsten Nieder, Thomas A Kämpe
BACKGROUND/AIM: To evaluate whether or not single patients report increased levels of anxiety and depression, compared to married or partnered patients scheduled to receive palliative radiotherapy. In principle, different levels of social support might cause such disparities. PATIENTS AND METHODS: Retrospective comparison of two groups of patients (28% single, overall 100 patients), who scored their symptoms before palliative radiotherapy with the Edmonton symptom assessment system (ESAS)...
March 2018: In Vivo
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