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In Vivo

Amer Afaneh, Michael Yang, Ameer Hamza, Edward Schervish, Richard Berri
Pheochromocytomas are rare tumors arising from chromaffin cells of the adrenal medulla and extramedullary sympathetic ganglia. The incidence of asymptomatic disease is rising due to increased detection rates from widespread use of computed tomography. We describe a case of one of the largest documented pheochromocytomas resected in the United States, an 18-cm tumor in a patient who presented with exertional dyspnea, abdominal pain, constipation, weight loss, and intermittent hypertension. After biochemical and appropriate imaging workup, the patient underwent an open resection of the mass...
May 2018: In Vivo
Nicolae Bacalbasa, Irina Balescu, Vladislav Brasoveanu
Celiac trunk stenosis is a relatively common finding; the most common causes of this obstruction are median arcuate ligament syndrome, pancreatitis, local invasion of various malignancies originating from the pancreatic body, atherosclerosis or it can be idiopathic. However, most such cases remain asymptomatic for a long period of time, especially due to the presence of a patent collateral circulation originating from the superior mesenteric artery. In certain cases, the patient might become symptomatic, diffuse post-prandial pain being reported...
May 2018: In Vivo
Motoaki Yasukawa, Noriyoshi Sawabata, Takeshi Kawaguchi, Norikazu Kawai, Shigeki Taniguchi
BACKGROUND/AIM: Lung biopsies might cause metastasis and/or dissemination. The aim of this study was to review our institutional experience and analyze the outcomes of resection for non-small cell lung cancer (NSCLC), in patients who had received preoperative transbronchial biopsy using fiberoptic bronchoscopy with fluoroscopic imaging (BFS). PATIENTS AND METHODS: The medical records of consecutive patients between 2010 and 2015 were retrospectively reviewed. Patients were divided into two groups (BFS and Non-BFS)...
May 2018: In Vivo
Tsutomu Namikawa, Sachi Tsuda, Kazune Fujisawa, Jun Iwabu, Sunao Uemura, Shigehiro Tsujii, Hiromichi Maeda, Hiroyuki Kitagawa, Michiya Kobayashi, Kazuhiro Hanazaki
Situs inversus totalis (SIT) is a congenital anomaly characterized by a complete mirror-image transposition of the thoracic and abdominal viscera. We report on a rare case of superficial spreading gastric cancer associated with SIT in a 66-year-old woman referred to our hospital for examination of gastric cancer initially diagnosed by medical check-up. Esophagogastroduodenoscopy showed a slightly depressed lesion in the lesser curvature side of the stomach. Abdominal contrast-enhanced computed tomography showed complete transposition of the abdominal viscera, confirming SIT...
May 2018: In Vivo
Chi-Cheng Lu, Wen-Kang Chen, Jo-Hua Chiang, Yuh-Feng Tsai, Yu-Ning Juan, Ping-Chin Lin, Yeu-Sheng Tyan, Jai-Sing Yang
BACKGROUND/AIM: Gadoxetate disodium (Primovist or Eovist) is extensively used as a hepatospecific contrast agent during magnetic resonance imaging (MRI) examinations. However, there is no information determining whether gadoxetate disodium has a cytotoxic impact and/or affects relative gene expression on liver cells. In the current study, we investigated the effects of gadoxetate disodium on cytotoxicity and the levels of gene expression in human normal Chang Liver cells. MATERIALS AND METHODS: The cytotoxic effect was detected via methyl thiazolyl tetrazolium (MTT) assay and 4',6-diamidino-2-phenylindole (DAPI) staining...
May 2018: In Vivo
Nozomi Iimori, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Koji Takada, Katsuyuki Takahashi, Takaharu Hatano, Tsutomu Takashima, Shuhei Tomita, Hisashi Motomura, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Studies have found that patients with cancer exhibit abnormal leukocyte fractions, such as elevated neutrophil count and diminished lymphocyte count, and that the neutrophil-to-lymphocyte ratio (NLR) provides a surrogate marker for prognosis and response to treatment of patients after radical surgery for several different types of cancer. However, few reports have addressed the association between the NLR and response to endocrine therapy. In this study, we carried out a clinical investigation to confirm whether or not the NLR predicted the response to endocrine therapy of stage IV breast cancer...
May 2018: In Vivo
Masaki Tomita, Takanori Ayabe, Ryo Maeda, Kunihide Nakamura
BACKGROUND: The systemic immune-inflammation index (SII) is reported to be associated with clinical outcomes and has been proven to be a promising prognostic indicator in several solid tumor types. To the best of our knowledge, however, no studies regarding SII in patients with resectable non-small cell lung cancer (NSCLC) are available. MATERIALS AND METHODS: Three hundred forty-one patients with NSCLC who underwent surgery at our Institution between 2008 and 2012 were included...
May 2018: In Vivo
Shohei Yoshiya, Kentaro Iwaki, Akihiro Sakai, Shunsuke Fujita, Takahide Kawasaki, Fumitaka Yoshizumi, Shoji Hiroshige, Masahiro Okamoto, Kengo Fukuzawa, Akira Motohiro, Yoshihiko Maehara
BACKGROUND: Although spontaneous tumour rupture is a life-threatening complication of hepatocellular carcinoma (HCC), staged hepatectomy for HCC controlled after transcatheter arterial embolization (TAE) could provide a better prognosis. Laparoscopic liver resection (LLR) has been accepted worldwide and has been expanded from minor resection to anatomical major resection. We herein report the first case of pure laparoscopic left hepatectomy for ruptured HCC controlled after TAE. CASE REPORT: A 66-year-old man was transferred to our Institute because of abdominal pain and decreased consciousness...
May 2018: In Vivo
Stefania Kokkali, Elli-Sophia Tripodaki, Maria Drizou, Dimitra Stefanou, Elpida Magou, Dimosthenis Zylis, Matthaios Kapiris, Despoina Nasi, Chara Georganta, Alexandros Ardavanis
BACKGROUND/AIM: During recent years, a survival advantage was reported for first-line treatment of advanced pancreatic cancer with two new regimens, FOLFIRINOX and gemcitabine/nab-paclitaxel, over gemcitabine monotherapy. Gemcitabine/nab-paclitaxel administration on days 1, 8 and 15 of a 4-week cycle is associated with some practical disadvantages. We adopted a biweekly regimen with the same dose density. PATIENTS AND METHODS: Patients with Eastern Cooperative Oncology Group performance status 0-2 diagnosed with advanced histologically or cytologically confirmed pancreatic cancer and no prior treatment were included in the study...
May 2018: In Vivo
Nicolae Bacalbasa, Irina Balescu, George Jinescu, Madalina Marcu, Andreea Contolenco, Doina Pop, Dragos Dobritoiu, Olivia Ionescu, Paris Ionescu, Claudia Stoica
Fat-forming solitary fibrous tumors arising from the kidney are extremely rare, with only few cases reported so far. We report the case of a 49-year-old patient investigated for lumbar pain and diagnosed preoperatively with a large retroperitoneal tumor destroying the right kidney. The patient was submitted to surgery, the tumor being resected en bloc with right nephrectomy. The histopathological studies demonstrated the presence of a hemangiopericytoma-like tumor with adipocytary component; the immunohistochemical studies demonstrated the presence of cluster of differentiation 34 (CD34), while human melanoma black (HMB45) staining was negative...
May 2018: In Vivo
Takashi Nonaka, Akiko Fukuda, Kyoichiro Maekawa, Shigeki Nagayoshi, Takayuki Tokunaga, Mitsutoshi Takatsuki, Tomoo Kitajima, Ken Taniguchi, Hikaru Fujioka
BACKGROUND/AIM: Extended total mesorectal excision (ETME) is defined as en bloc resection of the adjacent organs outside the mesorectal fascia, that is indicated in cases with locally advanced lower rectal cancer (T4 tumor). The aim of this study was to evaluate the clinical and oncological outcomes of laparoscopic ETME (L-ETME) for locally advanced lower rectal cancer. PATIENTS AND METHODS: The present study analyzed clinical outcomes and oncological outcomes of 11 consecutive patients who underwent L-ETME for cT4 lower rectal cancer in Nagasaki Medical Center between 2012 and 2015...
May 2018: In Vivo
Michitaka Kawano, Seiji Kaino, Shogo Amano, Shuhei Shinoda, Shigeyuki Suenaga, Manabu Sen-Yo, Isao Sakaida
BACKGROUND/AIM: Gemcitabine (GEM) sensitivity can help select the appropriate treatment for pancreatic cancer. We examined the association between HSP27 expression and GEM sensitivity. MATERIALS AND METHODS: A total of 19 patients with unresectable pancreatic cancer who underwent endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) were enrolled and treated with GEM alone. We measured the expression of heat shock protein 27 (HSP27) and phosphorylated HSP27(p-HSP27) in EUS-FNA samples and evaluated the effects of GEM treatment...
May 2018: In Vivo
Dirk Rades, Liesa Dziggel, Lisa Manig, Stefan Janssen, Mai Trong Khoa, Vuong Ngoc Duong, Vu Huu Khiem, Steven E Schild
BACKGROUND/AIM: This study aimed to create a predictive tool for estimating the remaining lifespan of patients after whole-brain irradiation (WBI) for cerebral metastases from bladder cancer. PATIENTS AND METHODS: In 34 of these patients clinical parameters were analyzed for survival including age at start of WBI, gender, Karnofsky score, number of cerebral metastases and involvement of extra-cranial sites of metastasis. RESULTS: Involvement of extra-cranial sites (14%) and Karnofsky score (9%) showed the greatest difference regarding 6-month survival and were considered for the tool...
May 2018: In Vivo
Ralf Ohlinger, Leonie Gieron, Rico Rutkowski, Thomas Kohlmann, Marek Zygmunt, Julia Unger
BACKGROUND/AIM: Using drains after breast surgery is a preventive, but invasive measure to reduce seroma formation. A polyurethane-based tissue adhesive (TissuGlu®) might facilitate drainage-free wound healing after mastectomy in a non-invasive manner. PATIENTS AND METHODS: Retrospectively, data from 84 patients (42 receiving TissuGlu®, 42 receiving a drainage) who underwent mastectomy, were collected (90 days postoperative follow-up). Study endpoints were defined as the number of fluid-related postoperative clinical interventions, cumulative volume of postoperative wound fluid, duration of hospitalization and postoperative complications...
May 2018: In Vivo
Hiroshi Ohtani, Kiyoshi Maeda, Shinya Nomura, Osamu Shinto, Yoko Mizuyama, Hiroji Nakagawa, Hisashi Nagahara, Masatsune Shibutani, Tatsunari Fukuoka, Ryosuke Amano, Kosei Hirakawa, Masaichi Ohira
BACKGROUND/AIM: A meta-analysis was conducted to evaluate and compare the short- and long-term outcomes of robot-assisted (RAS) and conventional laparoscopic surgery (LAS) for rectal cancer. MATERIALS AND METHODS: We searched MEDLINE for relevant papers published between 2010 and December 2017 by using specific search terms. We analyzed outcomes over short- and long-term periods. RESULTS: We identified 23 papers reporting results that compared RAS for rectal cancer with LAS...
May 2018: In Vivo
Sho Sato, Chikara Kunisaki, Hideaki Suematsu, Yusaku Tanaka, Hiroshi Miyamoto, Takashi Kosaka, Norio Yukawa, Kuniya Tanaka, Kei Sato, Hirotoshi Akiyama, Itaru Endo
BACKGROUND: Esophageal cancer often involves direct invasion of adjacent organs and patient survival rates are low. Sarcopenia has been reported to be associated with a poor prognosis in several types of malignancies. However, the impact of sarcopenia on the long-term survival of patients with unresectable locally advanced esophageal cancer remains unclear. PATIENTS AND METHODS: A total of 48 patients undergoing definitive chemoradiotherapy at our Institution from October 2012 to December 2015 were enrolled; their data were compared according to patient skeletal muscle index (SMI): low SMI (sarcopenia group), n=34; normal SMI (non-sarcopenia group), n=14...
May 2018: In Vivo
Hiroaki Soyama, Morikazu Miyamoto, Masashi Takano, Hideki Iwahashi, Kento Kato, Takahiro Sakamoto, Mika Kuwahara, Hiroki Ishibashi, Hiroko Matuura, Tomoyuki Yoshikawa, Tadashi Aoyama, Hitoshi Tsuda, Kenichi Furuya
BACKGROUND/AIM: The purpose of this study was to compare the clinical behavior of several grades of endometrioid carcinoma (EC) compared to high-grade serous carcinoma (HGSC), based on World Health Organization 2014 criteria. MATERIALS AND METHODS: Clinicopathological features were compared between all grades of EC and HGSC, and between HGSC and either grade 1/2 or grade 3 EC. RESULTS: Sixty-five patients with EC and 214 with HGSC were identified...
May 2018: In Vivo
Carlo M Oranges, Mathias Tremp, Wenjin Wang, Srinivas Madduri, Pietro G DI Summa, Reto Wettstein, Dirk J Schaefer, Daniel F Kalbermatten
BACKGROUND: Gracilis muscle flap is commonly used for the reconstruction of defects of the lower extremities. Preoperative evaluation of gracilis muscle dimension is a key aspect in surgical planning. This study aimed to determine whether patient height, weight, body mass index (BMI) and age are reliable proxy measurements of the mass of gracilis muscle flap. PATIENTS AND METHODS: Twenty-two patients treated for lower extremity reconstruction with free gracilis flap between December 2010 and December 2014 were considered...
May 2018: In Vivo
Masaharu Abe, Hiroaki Kawaguchi, Naoki Miura, Kohei Akioka, Miharu Ushikai, Sayumi Oi, Airo Yukawa, Tetsuya Yoshikawa, Hiroyuki Izumi, Masahisa Horiuchi
BACKGROUND/AIM: The aim of this study was to develop a method for sequentially collecting cerebrospinal fluid (CSF) from an unanesthetized microminipig, which shares many physiological and anatomical similarities with humans, such as diurnality, and investigate the diurnal variation of melatonin concentration in the CSF. MATERIALS AND METHODS: A catheter was placed percutaneously into the subarachnoid space of an anesthetized animal, and the tip of the catheter was placed into the cisterna magna under X-ray...
May 2018: In Vivo
Jueun Park, Song Kwon, Nathaniel S Hwang, Byung-Jae Kang
Bone morphogenetic protein-2 (BMP-2) effectively induces bone healing. However, the efficacy of BMP-2 relies heavily on its delivery vehicle because of its short half-life. We utilized a microcarrier fabricated by the cryopolymerization of gelatin methacrylate (cryoGelMA) infused with bone morphogenetic protein-2 (cryoGelMA-BMP-2) for the sustained and localized release of growth factors. Two dogs with radius and ulnar fractures were treated with implanted cryoGelMA-BMP-2 to accelerate bone healing. The cases were followed up for 6 months and 2 months after surgery, respectively...
May 2018: In Vivo
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