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In Vivo

Mansour Al-Zghloul, Holger Wenz, Máté Maros, Johannes Böhme, Christoph Groden, Alex Förster
BACKGROUND/AIM: In stroke due to large vessel occlusion, thrombotic material can be demonstrated by the susceptibility vessel sign (SVS), a hypointense signal on T2*-weighted gradient echo magnetic resonance (GRE) images. In the present study, we evaluated the value of GRE for the detection of perforating artery occlusion in hyperacute lacunar infarction (LI). MATERIALS AND METHODS: The presence of SVS on GRE in 58 patients with LI who underwent magnetic resonance imaging within 24 hours after symptom onset was analyzed...
July 2018: In Vivo
Nicolae Bacalbasa, Irina Balescu, Iulian Brezean, Mihaela Vilcu, Vladislav Brasoveanu
Peritoneal carcinomatosis from ovarian cancer is unfortunately a very common finding, especially in patients diagnosed in very late stages of the disease. Nonetheless, it is not the only pathological condition inducing a diffuse involvement of the peritoneum; other entities can have an infectious or miscellaneous origin. However, the association of peritoneal carcinomatosis and parasitic infection has never been reported so far. We present the case of a 50-year-old patient who had been submitted to surgery for a hepatic hydatid cyst...
July 2018: In Vivo
Shintaro Shiba, Masahiko Okamoto, Hiroki Kiyohara, Naoko Okano, Yuya Yoshimoto, Hiroto Murata, Daisuke Irie, Hiroyuki Katoh, Takashi Nakano
BACKGROUND/AIM: The clinical outcomes of post-mastectomy radiation therapy (PMRT) without bolus remain to be fully examined, so that we evaluated clinical outcomes of PMRT without bolus and to measure the chest-wall dose surface histogram (DSH) parameters. PATIENTS AND METHODS: Fifty-two patients with breast cancer who received PMRT without bolus were retrospectively analyzed. DSH values of the percentage of maximum dose (Dmax ) were measured. RESULTS: All patients completed the treatment; the median follow-up period was 22...
July 2018: In Vivo
Haw-En Wang, Chih-Lang Lin, Tai-Long Pan, Chau-Ting Yeh
BACKGROUND/AIM: Our previous cDNA microarray study revealed increased cellular mRNA levels of a panel of genes, including kallikrein-8 (KLK8), after long-term telbivudine treatment in chronic hepatitis B patients. The aim of this study was to verify whether serum protein levels of KLK8, a cancer-related enzyme, are indeed increased after telbivudine treatment. PATIENTS AND METHODS: A total of 83 chronic hepatitis B patients receiving telbivudine for >2 years were retrospectively analyzed...
July 2018: In Vivo
Irene Vraka, Evangelia Panourgias, Emmanouil Sifakis, Andreas Koureas, Petros Galanis, Dionysios Dellaportas, Athanasios Gouliamos, Aristides Antoniou
BACKGROUND/AIM: Little is known about the correlation between contrast-enhanced ultrasound (CEUS) characteristics and pathological prognostic factors in breast cancer. The aim of this study was to explore the correlation between CEUS characteristics and pathological prognostic factors. PATIENTS AND METHODS: A retrospective study with 34 malignant breast lesions was conducted. CEUS characteristics included qualitative characteristics (e.g. lesion's enhancement degree and order, internal lesion homogeneity etc...
July 2018: In Vivo
Michihiro Koizumi, Takeshi Yamada, Seiichi Shinji, Yasuyuki Yokoyama, Goro Takahashi, Takuma Iwai, Kohki Takeda, Keisuke Hara, Keiichiro Ohta, Eiji Uchida, Hiroshi Yoshida
BACKGROUND/AIM: The combination of oxaliplatin, leucovorin and fluorouracil (FOLFOX) has been established as postoperative adjuvant chemotherapy for stage III colon cancer. However, the safety and efficacy of neoadjuvant FOLFOX in patients with rectal cancer are still controversial. This prospective pilot study aimed to evaluate the feasibility of neoadjuvant FOLFOX therapy without radiation for baseline resectable rectal cancer (RC). PATIENTS AND METHODS: The study included 30 patients with clinical stage II/III RC between February 2012 and December 2015...
July 2018: In Vivo
Kota Kida, Tomonori Terada, Nobuhiro Uwa, Yoshihiko Omori, Takashi Fujii, Yasuhiko Tomita, Kenzo Tsuzuki, Hiroki Nishikawa, Masafumi Sakagami
BACKGROUND/AIM: Prognostic impact of p16 expression in patients with oropharyngeal squamous cell carcinoma (OSCC) undergoing surgery is not fully examined. The aim of this study was to clarify these issues. PATIENTS AND METHODS: Sixty-four OSCC subjects were analyzed. Immuno-histochemical staining of p16, a surrogate marker for human papillomavirus (HPV), was performed histopathologically. Data were retrospectively analyzed according to p16 positivity and factors linked to prognosis were also analyzed...
July 2018: In Vivo
Eftychios Siniorakis, Spyridon Arvanitakis, Christina Tsitsimpikou, Konstantinos Tsarouhas, Panagiotis Tzevelekos, Stamatia Panta, Fotini Aivalioti, Constantinos Zampelis, Filippos Triposkiadis, Sotiria Limberi
BACKGROUND/AIM: Several risk scores can stratify patients with acute heart failure (AHF) at the Emergency Department (ED). Registration of vital signs, such as blood pressure (BP), heart rate (HR) and respiratory rate (RR) upon admission is mandatory. Nevertheless, measurement of RR remains neglected worldwide. PATIENTS AND METHODS: The predictive value of RR in classifying patients with AHF was investigated by processing several vital signs recorded in the ED. RESULTS: HR and RR individually did not discriminate patients according to hospitalization length, Intensive Care Unit (ICU) admittance, mechanical respiratory support or death...
July 2018: In Vivo
Nicolae Bacalbasa, Irina Balescu, Alina Tanase, Mihai Pautov, Iulian Brezean, Mihaela Vilcu, Vladislav Brasoveanu
Splenic artery aneurysms are common arterial lesions which might remain asymptomatic for a long period of time. In certain cases, these lesions might encounter a significant growth and might become symptomatic. Once diagnosed, a therapeutic strategy should be taken in consideration in order to avoid the apparition of life-threatening complications such as aneurysmal rupture. This is a case report of a 45-year-old patient diagnosed with a splenic artery aneurysm who was successfully submitted to an aneurysmal resection en bloc with distal spleno-pancreatectomy and parcelar gastrectomy...
July 2018: In Vivo
Nicolae Bacalbasa, Irina Balescu, Alina Tanase, Iulian Brezean, Mihaela Vilcu, Vladislav Brasoveanu
Paragangliomas, as well as phaeochromocytomas, are vascular neuroendocrine lesions that might be encountered between neck and pelvis. In certain cases, a preoperative diagnosis is difficult to be established, so resection might be needed whenever a suspect mass is discovered at the imaging studies. Moreover, there are cases in which resection and reconstruction of an important vascular structure might be imposed. In this case report a 59-year-old patient was investigated for upper abdominal pain with postprandial features and was diagnosed with a retroperitoneal tumor of 4/6/7cm invading the celiac trunk...
July 2018: In Vivo
Chuang-Chi Liaw, Cheng-Keng Chuang, Ying-Hsu Chang, John Wen-Cheng Chang, Tzu-Yao Liao, Yu-Hsiang Juan
BACKGROUND/AIM: Bladder cancer can spread from the sub-peritoneal space superior and posterolateral to the peritoneal cavity via the peritoneal lining. The aim of this study was to improve the identification of peritoneal spread from bladder urothelial carcinoma based on computed tomography (CT) scans. MATERIALS AND METHODS: This is a retrospective study including patients selected with the following criteria: (i) pathology-confirmed urothelial carcinoma; (ii) peritoneal spread identified on CT scans from axial and corona views, either initially or after radical/partial cystectomy, concomitant chemoradiotherapy (CCRT), or radiotherapy...
July 2018: In Vivo
Hiroaki Iwamoto, Kouji Izumi, Ariunbold Natsagdorj, Tomoyuki Makino, Takahiro Nohara, Kazuyoshi Shigehara, Yoshifumi Kadono, Atsushi Mizokami
BACKGROUND: The effectiveness and safety of pegfilgrastim during bleomycin, etoposide and cisplatin (BEP) chemotherapy have not yet been investigated. PATIENTS AND METHODS: Patients with germ cell tumors (GCTs) who received pegfilgrastim during BEP at the Kanazawa University Hospital between January 2014 and December 2016 were retrospectively analyzed. The frequency of adverse events and effectiveness in inhibiting neutropenia were compared between cycles using pegfilgrastim and those using filgrastim...
July 2018: In Vivo
Carlo M Oranges, Barbara Ling, Mathias Tremp, Reto Wettstein, Daniel F Kalbermatten, Dirk J Schaefer
BACKGROUND: The radial forearm flap (RFF) and the anterolateral thigh flap (ALT) are commonly used for the reconstruction of head and neck soft-tissue defects. The aim of the study was to investigate and compare the surgical outcomes, complications and systemic condition of the patient after reconstruction of extensive head and neck defects with ALT or RFF following cancer extirpation. PATIENTS AND METHODS: Between August 2011 and November 2013, a total of 36 patients affected by head and neck cancer (31 males and five females; mean age=64...
July 2018: In Vivo
Kenji Nakahama, Akihiro Tamiya, Shun-Ichi Isa, Yoshihiko Taniguchi, Takayuki Shiroyama, Hidekazu Suzuki, Takako Inoue, Motohiro Tamiya, Tomonori Hirashima, Fumio Imamura, Shinji Atagi
BACKGROUND: Compared to conventional cytotoxic chemotherapy, immune checkpoint inhibitors have shown a significant efficacy in the treatment of lung cancer. Although interstitial lung disease (ILD) is an important adverse event in immunotherapy, risk factors for ILD remain unclear. PATIENTS AND METHODS: In this multicenter cohort study (UMIN000025908), 201 patients who were treated with nivolumab were retrospectively reviewed. Associations between the incidence of ILD and patient characteristics were evaluated...
July 2018: In Vivo
Ioannis D Kostakis, Nikolaos Machairas, Zoe Garoufalia, Anastasia Prodromidou, Georgios C Sotiropoulos
BACKGROUND/AIM: Novel techniques for liver parenchymal transection have emerged and they are available to the hepatobiliary surgeon. The aim of our study was to compare two types of ultrasonic scalpels (Lotus and Harmonic) and examine how they perform either alone or in combination with the SonaStar ultrasonic surgical aspiration system regarding postoperative bleeding and bile leakage. PATIENTS AND METHODS: Our prospectively maintained database of patients who underwent liver resections in our Department was reviewed...
July 2018: In Vivo
Elisabetta Bonzano, Marina Guenzi, Renzo Corvò
AIM: To evaluate cardiotoxicity in patients with human epidermal growth factor receptor 2+ (HER2+) breast cancer (29 left-sided, 23 right-sided) treated with adjuvant whole-breast hypofractionated radiotherapy (HRT) concurrently administered with the humanized monoclonal antibody to HER2, trastuzumab. PATIENTS AND METHODS: From February 2008 to June 2017, 52 patients received three-dimensional conformal RT, with different HRT schemes. Echocardiogram monitoring was used to evaluate the decrease in left ventricular ejection fraction (LVEF)...
July 2018: In Vivo
Nithikoon Aksorn, Sittiruk Roytrakul, Suthathip Kittisenachai, Kawin Leelawat, Pithi Chanvorachote, Supachai Topanurak, Shinjiro Hamano, Usa Lek-Uthai
BACKGROUND/AIM: Early detection of disease is a pivotal factor for determining prognosis and clinical outcome of patients with cancer. As cholangiocarcinoma (CCA) is currently difficult to detect and most cases of such cancer present with late-stage disease at the time of initial diagnosis, we employed proteomic analysis of the bile to identify potential candidate biomarkers for Opisthorchis viverrini (OV)-associated CCA. MATERIALS AND METHODS: Proteins in pooled bile samples from patients with CCA and OV infection, with CCA without OV infection, with OV infection but no CCA, and with neither OV infection nor CCA were separated by 15% sodium dodecyl sulfate-polyacrylamide gel electrophoresis, in-gel trypsin digestion and analyzed by liquid chromatography-tandem mass spectrometry...
July 2018: In Vivo
Chrisanthy Vlachakis, Konstantina Dragoumani, Sofia Raftopoulou, Meropi Mantaiou, Louis Papageorgiou, Spyridon Champeris Tsaniras, Vasileios Megalooikonomou, Dimitrios Vlachakis
BACKGROUND/AIM: The aim of the present study was to examine the relation between understanding of emotions and cardiovascular related diseases, namely coronary heart disease, diabetes mellitus and obesity. The uniqueness of this study lies in the fact that it examined the relationship between the cardiovascular related diseases named above and the understanding of emotions in the context of Emotional Intelligence (EI). PATIENTS AND METHODS: The study was conducted in 300 participants during a 3 year period...
July 2018: In Vivo
Kosuke Kashiwabara, Hiroshi Semba, Shinji Fujii, Shinsuke Tsumura
We reported that epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor re-administration (TKI-R) might be salvage therapy in patients with advanced non-small cell lung cancer after recovery from EGFR-TKI-induced interstitial lung disease (ILD). Here we retrospectively evaluated whether chemotherapy re-administration (CT-R) was effective in patients after chemotherapy-induced ILD. After providing their informed consent due to the risk of severe ILD, five patients received CT-R and six received TKI-R with oral administration of 0...
July 2018: In Vivo
Máté E Maros, Ralf Wenz, Alex Förster, Matthias F Froelich, Christoph Groden, Wieland H Sommer, Stefan O Schönberg, Thomas Henzler, Holger Wenz
BACKGROUND: This feasibility study of text-mining-based scoring algorithm provides an objective comparison of structured reports (SR) and conventional free-text reports (cFTR) by means of guideline-based key terms. Furthermore, an open-source online version of this ranking algorithm was provided with multilingual text-retrieval pipeline, customizable query and real-time-scoring. MATERIALS AND METHODS: Twenty-five patients with suspected stroke and magnetic resonance imaging were re-assessed by two independent/blinded readers [inexperienced: 3 years; experienced >6 years/Board-certified)...
July 2018: In Vivo
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