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In Vivo

Anastasios Tsekouras, Dimitrios Mantas, Diamantis I Tsilimigras, Demetrios Moris, Michael Kontos, George C Zografos
BACKGROUND: Adipose tissue contains variable amounts of stem cells that have recently attracted increased interest due to their strong proliferative and differentiation capacity. However, significant heterogeneity exists in terms of stem cell yield and viability profile among individuals as well as different donor areas. MATERIALS AND METHODS: Between June 2016 and July 2016, forty (40) women underwent outpatient cosmetic liposuction procedures conferring a total of 53 lipoaspirates; inner thigh (n=13), outer thigh (n=9), abdomen (n=9), waist (n=16) and inner knee (n=6)...
November 2017: In Vivo
Haruhiko Yamazaki, Hiroyuki Iwasaki, Toshinari Yamashita, Tatsuya Yoshida, Nobuyasu Suganuma, Takashi Yamanaka, Katsuhiko Masudo, Hirotaka Nakayama, Kaori Kohagura, Yasushi Rino, Munetaka Masuda
BACKGROUND: Thyroid dysfunction is occasionally reported after the administration of nivolumab. We report on the incidence of and risk factors for nivolumab-induced thyroid dysfunction in patients with non-small lung cancer. PATIENTS AND METHODS: A total of 82 patients who received nivolumab between January 2016 and December 2016 at the Kanagawa Cancer Center were included. Prior to nivolumab treatment, 72 patients had normal thyroid function. RESULTS: Among the 72 patients with normal thyroid function prior to nivolumab treatment, the incidence of thyroid dysfunction was 19...
November 2017: In Vivo
Elena Bargagli, Marco Palazzi, Francesco Perri, Elena Torricelli, Elisabetta Rosi, Alessandra Bindi, Massimo Pistolesi, Luca Voltolini
A patient treated for 4 months with hydroxycarbamide (hydroxyurea) for chronic myelomonocytic leukemia was admitted to hospital for recently developed severe dyspnea and acute respiratory failure. The computed tomographic scan of the chest showed diffuse ground glass opacities, some centrilobular low-density nodules (resembling hypersensitivity pneumonitis-like pattern), and minimal interstitial reticulation of the subpleural region. The analysis of bronchoalveolar lavage fluid excluded infection, as did serological examinations...
November 2017: In Vivo
Hiroshi Fukushima, Masaki Kobayashi, Keizo Kawano, Shinji Morimoto
BACKGROUND/AIM: We investigated the effect of bacteriuria and pyuria on intravesical recurrence (IVR) in patients with upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy (RNU). PATIENTS AND METHODS: Preoperative bacteriuria and pyuria were defined as urine containing ≥5 bacteria/high-power field (HPF) and >5 white blood cells/HPF, respectively. Their associations with IVR were evaluated in 97 patients with UTUC undergoing RNU. RESULTS: Preoperative bacteriuria [n=15 (15%)] was significantly associated with preoperative pyuria [n=42 (43%), p<0...
November 2017: In Vivo
Yoshikazu Kanazawa, Itsuo Fujita, Daisuke Kakinuma, Yuto Aoki, Hitoshi Kanno, Hiroki Arai, Kunihiko Matsuno, Tomohiro Shimoda, Takeshi Matsutani, Nobutoshi Hagiwara, Tsutomu Nomura, Takeshi Yamada, Shunji Kato, Zenya Naito, Hideaki Takasaki, Eiji Uchida
Brain metastases originating from esophageal or gastric cancer are rare, accounting for 2.1-3.3% of all brain tumors registered in Japan. There are no established therapeutic measures for brain metastases, which accordingly have a poor prognosis. We present here a patient who survived for 5 years after surgery and gamma knife treatment of a cerebellar metastasis from esophagogastric adenocarcinoma. The primary gastric cancer was treated by laparotomy with total gastrectomy, splenectomy, and D2 lymphadenectomy...
November 2017: In Vivo
Vania Cuna, Viola Menghi, Giorgia Comai, Maria Cappuccilli, Giuseppe Cianciolo, Concettina Raimondi, Francesco Grammatico, Gabriele Donati, Olga Baraldi, Irene Capelli, Gaetano LA Manna
BACKGROUND/AIM: Clinical and subclinical hypothyroidism is more common in patients with end-stage renal disease (ESRD) than in the general population. Patients with ESRD with hypothyroidism are more susceptible to cardiovascular disease, with an increased risk of mortality than those with normal thyroid function. Moreover, these patients have higher incidence of benign and malignant nodules. PATIENTS AND METHODS: This was a retrospective study on 2,147 patients with ESRD on the renal transplant waiting list between 2000 and 2015 aimed at identifying the presence of hypothyroidism and associated variables...
November 2017: In Vivo
Katarina Kolostova, Adam Rzechonek, Jan Schützner, Robert Grill, Robert Lischke, Pavel Hladik, Jan Simonek, Vladimir Bobek
BACKGROUND: In general, the presence of circulating tumor cells (CTCs) in peripheral blood (PB) is associated with a relative shorter overall survival in cancer patients. The clinical utility of CTC diagnostics is changing: from prognostic test to an assay predicting therapy response, enabling the right choice of therapy and monitoring the effect of administered therapy. We present two case reports of patients with suspicion of lung and pancreatic cancer, without obtainable preoperative biopsy for histological verification...
November 2017: In Vivo
Ioannis Bountouris, Demetrios Moris, Diamantis I Tsilimigras, George Laoutaris, Georgia Kritikou, Viktoria-Varvara Palla, Georgios Karaolanis
BACKGROUND/AIM: Cytomegalovirus (CMV) infection is a common disease especially in young adults. Thromboembolism like deep vein thrombosis and pulmonary embolism is increased among patients with CMV infection. Most cases represent immunocompromised patients usually treated with low molecular weight heparin. CASE REPORT: Herein, we describe a 25-year-old immunocompetent male who presented at the emergency department with sudden onset of chest pain. One month prior to admission, he had developed persistent fever and cough and the diagnosis of CMV infection had been established...
November 2017: In Vivo
Jens Büntzel, Irene Kusterer, Yvonne Rudolph, Thomas Kubin, Oliver Micke, Jutta Hübner
BACKGROUND/AIM: Physical activities are an essential part of patients' rehabilitation in oncology. For cancer patients special sport groups for rehabilitation exist and are reimbursed by the statutory health system. The aim of our study was to evaluate patients' knowledge and acceptance of these offers and their actual sportive engagement. PATIENTS AND METHODS: We used a standardized questionnaire which was distributed in medical oncology and ENT oncology practice...
November 2017: In Vivo
Ali Gür, Hakan Oguzturk, Adem Köse, M Gökhan Turtay, Veysel Ersan, Yaşar Bayindir, Volkan Ince, Sukru Gurbuz, Neslihan Yucel
BACKGROUND/AIM: Infections are one of the most important causes of mortality and morbidity after liver transplantation as in all transplantations. Infectious complications are known to be among the preventable causes with appropriate diagnosis and treatment. So early prediction of the risk of infections will provide an effective approach to determine the local antimicrobial resistance and prevention of specific risk factors. The aim of this study was to deterimne whether specific markers are useful or not to deterimne a suspected infection in patients that have undergone liver transplantation...
November 2017: In Vivo
Marnonette Marallag, Amitkumar Patel, Myunghan Choi, Mark N Wong, Anil B Seetharam
BACKGROUND/AIM: The neutrophil-lymphocyte ratio (NLR) has gained attention as an index of inflammation in patients with chronic hepatitis B virus (HBV); however, changes with nucleoside analog therapy require investigation. PATIENTS AND METHODS: We carried out a retrospective study identifying monoinfected HBV patients initiated on therapy with NLR follow-up over 1 year. Biochemistries recorded at treatment initiation and 1 year included alanine aminotransferase (ALT), Model for End Stage Liver Disease (MELD) score, and NLR...
November 2017: In Vivo
Christos Damaskos, Nikolaos Garmpis, Anna Garmpi, Afroditi Nonni, Stratigoula Sakellariou, Georgios-Antonios Margonis, Eleftherios Spartalis, Dimitrios Schizas, Nikolaos Andreatos, Eleni Magkouti, Alexandros Grivas, Konstantinos Kontzoglou, Matthew J Weiss, Efstathios A Antoniou
BACKGROUND/AIM: Epithelioid angiomyolipoma of the liver is a rare benign mesenchymal tumor that usually presents in adult female patients. It most frequently occurs in the kidney, with the liver being the second most common site of involvement. Angiomyolipoma belongs to a family of tumors arising from perivascular epithelioid cells, but in rare cases may also have cystic features. We report our experience via the first case of hepatic angiomyolipoma treated by laparoscopic approach. PATIENTS AND METHODS: We present the case of a 50-year-old female patient complaining of abdominal pain...
November 2017: In Vivo
Iván Péter, Anna Jagicza, Zénó Ajtay, Imre Boncz, István Kiss, Katalin Szendi, Péter Kustán, Balázs Németh
BACKGROUND/AIM: This study aimed to report a balneotherapy-based psoriasis rehabilitation protocol and assess its effectivity. PATIENTS AND METHODS: Eighty psoriatic patients who underwent a 3-week-long inward balneotherapy-based rehabilitation were enrolled. Psoriasis Area and Severity Index (PASI) score and high sensitivity C-reactive protein (CRP) were determined on admission and before discharge. RESULTS: The mean PASI score and CRP level -determined on admission and before discharge-decreased significantly after the 3-week-long rehabilitation 7...
November 2017: In Vivo
Susanne Wiegand, Afshin Teymoortash, Holger Hanschmann
BACKGROUND: Bilateral vocal fold paralysis can result in shortness of breath and severe dyspnea which can be life-threatening. PATIENTS AND METHODS: Thirty-five patients with bilateral vocal fold paralysis who underwent endo-extralaryngeal laterofixation according to Lichtenberger were retrospectively analyzed regarding etiology, symptoms, treatment and complications. RESULTS: In 27 patients, laterofixation of the vocal cord alone was performed...
November 2017: In Vivo
Stefan Baumann, Marlon Rutsch, Tobias Becher, Philipp Kryeziu, Holger Haubenreisser, Nils Vogler, Celi Anne Schoenike, Martin Borggrefe, Stefan O Schoenberg, Ibrahim Akin, Thomas Henzler, Dirk Lossnitzer
BACKGROUND/AIM: To evaluate the hypothesis that patients with suspected coronary artery disease (CAD) assessed using rest dual-energy computed tomography-derived myocardial perfusion imaging (DECT-P), could have fewer invasive coronary angiographies (ICA), showing non-obstructive CAD. MATERIALS AND METHODS: Patients who had undergone coronary computed tomography angiography (cCTA), rest DECT-P and ICA were analyzed. RESULTS: We evaluated 51 patients (62...
November 2017: In Vivo
Yuki Naito, Yutaka Yoshikawa, Katsuhiko Yoshizawa, Akiko Takenouchi, Hiroyuki Yasui
BACKGROUND/AIM: Metabolic syndrome-induced lifestyle-related diseases include diabetes mellitus (DM) and hypertension, and Zn-based compounds have effects on DM. We aimed to investigate the ameliorating effects of bis(hinokitiolato)Zn, [Zn(hkt)2] on lipid metabolism in the liver and kidney, histopathologically. MATERIALS AND METHODS: We used a high-fat diet (HFD)-fed C57BL/6J mouse model and administered a diet containing 10-20 mg Zn/kg body weight (BW) or 20 mg pioglitazone/kg BW as the positive control...
November 2017: In Vivo
Şerban Comşa, Raluca Amalia Ceaușu, Roxana Popescu, Anca Maria Cîmpean, Marius Raica
BACKGROUND/AIM: To analyze the interaction between the human mesenchymal stem cells (hMSC) and the chick embryo chorioallantoic membrane (CAM), in order to assess the still obscure process of vasculogenesis. MATERIALS AND METHODS: We implanted hMSC onto CAM and we analyzed the morphology and the immunohistochemical profile of CAM. RESULTS: hMSC adhered to CAM, few of them entered the chorionic epithelium and the mesoderm and developed a CD44(-)/Ki67(-) status...
November 2017: In Vivo
Maria Kyriakidou, Jane Anastassopoulou, Aristeidis Tsakiris, Maria Koui, Theophile Theophanides
BACKGROUND/AIM: Mid-infrared spectroscopy (4000-500 cm-1) was used to analyze the spectral changes and differences of the characteristic absorption bands of the skin components due to cancer development for early clinical diagnosis. MATERIALS AND METHODS: Human biopsies from basal cell carcinoma, malignant melanoma, and nevus were used, while normal skin tissue served as a control. RESULTS: The high quality of Fourier-transform infrared (FT-IR) spectra showed that upon cancer development the intensity of the absorption band at approximately 3062 cm-1 was increased, indicating that most of the proteins had the configuration of amide B and the β-sheet protein structure predominated...
November 2017: In Vivo
Keumyoung So, Yoonyoung Chung, Sun-Kyoung Yu, Yonghyun Jun
BACKGROUND/AIM: Neurogenesis is a complex process to generate new neurons from neural progenitor cells. Neural progenitor cells are observed in two principal neurogenic regions of the forebrain, the subventricular zone and the subgranular zone of the hippocampal dentate gyrus. The cerebral cortex also plays a role as the neurogenic zone under hypoxic conditions. Hypoxia has many effects on neurogenesis, but the effect of chronic prenatal hypoxia on paired box 6 (Pax6), a protein that plays an important role in neurogenesis, has not been studied in vivo...
November 2017: In Vivo
Seung-Jun Lee, Min-Ok Ryu, Min-Soo Seo, Sang-Bum Park, Jin-Ok Ahn, Sei-Myoung Han, Kyung-Sun Kang, Dong-Ha Bhang, Hwa-Young Youn
BACKGROUND/AIM: The kidney excretes waste materials and regulates important metabolic functions, and renal disorders constitute a significant medical problem and can result in fatalities. In the present study, mesenchymal stem cells derived from canine umbilical cord blood (cUCB-MSCs) were isolated and evaluated for their ability to improve renal function in a canine model of acute kidney injury (AKI). MATERIALS AND METHODS: The canine AKI model was developed by i...
November 2017: In Vivo
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