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In Vivo

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November 2016: In Vivo
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November 2016: In Vivo
Charalampos Siristatidis, George Salamalekis, Paraskevi Vogiatzi, Tereza Vrantza, Paraskevi Matsota, Vasileios Pergialiotis, Nikolaos Papantoniou
AIM: To provide results of the use of estradiol pretreatment in a combination of an ultrashort gonadotropin-releasing hormone (GnRH) agonist and antagonist protocol, in an attempt to improve the clinical outcomes in "poor responders", according to the Bologna criteria, undergoing in vitro fertilization (IVF). PATIENTS AND METHODS: We applied estradiol pretreatment to 20 participants before the initiation of a combination of an ultrashort GnRH agonist plus an GnRH antagonist protocol followed by high doses of gonadotropins; the control group consisted of 20 subfertile participants with matching age, body mass index (BMI), basal follicle-stimulating hormone (FSH) and anti-Müllerian hormone (AMH), antral follicle count (AFC) and cause of subfertility, conforming with the same inclusion criteria and treated with a fixed GnRH antagonist protocol...
November 2016: In Vivo
Dimitrios Schizas, Demetrios Moris, Prodromos Kanavidis, Adamantios Michalinos, Athanasios Sioulas, Kitty Pavlakis, Anastasios Machairas, Theodoros Liakakos
BACKGROUND: Epithelial-mesenchymal transition is one of the mechanisms that contribute to the aggressiveness of cancer. CD44 antigen is an emerging biomarker that is currently being evaluated in the literature in the frame of epithelial-mesenchymal transition. The aim of this study was to evaluate the expression of CD44 in relation to several clinicopathological parameters in gastric and esophageal carcinomas. MATERIALS AND METHODS: This historical cohort survey was performed on gastric and esophageal tumors obtained from 86 patients who underwent resection from 2003 until 2011...
November 2016: In Vivo
Francesco Semeraro, Eliana Forbice, Giuseppe Nascimbeni, Marco Taglietti, Vito Romano, Germano Guerra, Ciro Costagliola
AIM: To evaluate in vivo changes after therapy using autologous serum (AS) eye drops in Sjögren's syndrome (SS)-related dry eyes by confocal microscopy. PATIENTS AND METHODS: In this study, 24 patients with SS-related dry eyes [12 in AS eye drop therapy and 12 in artificial tear (AT) therapy] and 24 healthy volunteers were recruited. Ocular Surface Disease Index (OSDI), central corneal thickness, tear film, break-up time, corneal and conjunctival staining, Schirmer's test and corneal confocal microscopy were investigated...
November 2016: In Vivo
Christos Yapijakis, Nikos Pachis, Dimitris Avgoustidis, Mary Adamopoulou, Zoe Serefoglou
BACKGROUND: Thrombophilia-related mutations, such as coagulation factor V Leiden and factor II (G20210A), have been associated with female infertility due to spontaneous abortions during pregnancy. The possible role of mutations of these two factors in male infertility has not been studied to date. MATERIALS AND METHODS: A total of 208 unrelated Greek men were investigated, including 108 infertile men with idiopathic oligozoospermia, azoospermia, and oligozoospermia of various etiologies, as well as 100 fertile male controls...
November 2016: In Vivo
Gen Suzuki, Hideya Yamazaki, Hideya Takenaka, Norihiro Aibe, Koji Masui, Takuya Kimoto, Kotoha Tatekawa, Akihiro Nakashima, Tadashi Takenaka, Jun Asai, Satoshi Komori, Makoto Wada, Norito Katoh, Kei Yamada
AIM: To examine the role of radiation therapy (RT) and factors' influence on tumor control for angiosarcoma of the face and scalp (AS-FS). PATIENTS AND METHODS: We reviewed the records of 14 patients with histopathology proven AS-FS (median age=77 years) who underwent RT between 2000 and 2015. A total dose of 60 to 100 Gy was administered in 24 to 50 fractions. The median calculated biological effective dose (BED) was 93 Gy (range=63.25-120) based on α/β=10. The median follow-up was 16 months (range=5-62)...
November 2016: In Vivo
Dirk Rades, Lena Sehmisch, Amira Bajrovic, Stefan Janssen, Steven E Schild
BACKGROUND/AIM: Most patients with multiple brain metastases from melanoma receive whole-brain irradiation. In a previous study, doses >30 Gy resulted in better outcomes than 10×3 Gy. However, the optimal dose-fractionation regimen has not yet been defined. This study compared 20×2 Gy over four weeks, which was used in the previous study, to 12×3 Gy over two-and-a-half weeks. PATIENTS AND METHODS: Eleven patients treated with 20×2 Gy for multiple brain metastases were compared to 12 patients treated with 12×3 Gy...
November 2016: In Vivo
Alexander Kumar
AIM: HIV infections occur across the Arctic but their incidence among aboriginal populations varies vastly. At the time this research was initiated there were no data on their occurrence, risk of HIV/AIDS or preventive strategies among Inuit living in the Nunavut territory of Canada. This review is the first to assess the risk of HIV infection among Inuit and evaluate current prevention strategies among Canadian-Inuit populations. MATERIALS AND METHODS: The contents of this article are based on the author's own research, undertaken during 3 visits to the Canadian Arctic and the published literature...
November 2016: In Vivo
Balázs Németh, Lóránd Kellényi, István Péterfi, Tamás Simor, Diána Ruzsa, Holczer Lőrinc, István Kiss, Iván Péter, Zénó Ajtay
BACKGROUND/AIM: The signal-averaging (SA) technique is used to record high-resolution electrocardiograms (HRECGs) showing cardiac micropotentials. We aimed to develop a non-invasive signal-averaging-based portable bedside device to determine His-ventricle interval. PATIENTS AND METHODS: After amplifying the HRECG recordings, signal duration and voltage can be measured up to four decimal precision. To validate our system, comparison of the invasively and non-invasively determined HV intervals has been performed in 20 patients...
November 2016: In Vivo
Masanobu Nakajima, Masakazu Takahashi, Yasushi Domeki, Hitoshi Satomura, Hiroto Muroi, Maiko Kikuchi, Hideo Ogata, Satoru Yamaguchi, Kinro Sasaki, Makoto Sakai, Makoto Sohda, Tatsuya Miyazaki, Hiroyuki Kuwano, Hiroyuki Kato
BACKGROUND/AIM: Adequate mediastinal lymphadenectomy during thoracoscopic esophagectomy (TE) requires an extensive operating field. In order to rectify this problem, we developed slender tracheal forceps that can pass through a 12-mm trocar. PATIENTS AND METHODS: TE in the prone position was performed in 58 patients with esophageal cancer using slender tracheal forceps. Perioperative and postoperative clinical data were compared against those of 61 patients who underwent transthoracic open esophagectomy (OE)...
November 2016: In Vivo
Tomoyuki Nagata, Yuen Nakase, Kei Nakamura, Akira Sougawa, Satoshi Mochiduki, Shozo Kitai, Seishiro Inaba
BACKGROUND: Nutritional status influences cancer prognosis. Measurement of the area of the psoas muscle on computed tomography is useful for evaluation of skeletal muscle mass and prediction of prognosis. PATIENTS AND METHODS: The psoas muscle index (PMI) was determined in 42 patients undergoing surgery for stage 4 colorectal cancer. Patients were classified into high and low PMI groups using a cutoff of 5.5×10(-4) cm(2) m(-2) Relationships of PMI with prognosis, chemotherapy period, and postoperative complications were examined...
November 2016: In Vivo
Carsten Nieder, Astrid Dalhaug, Adam Pawinski, Bård Mannsåker, Ellinor Haukland
BACKGROUND/AIM: Patients with bone-only metastases survive longer than patients with widespread visceral disease. We analyzed the prognostic impact of different baseline parameters, such as abnormal blood tests and receptor status in patients who received local radiotherapy, in addition to contemporary systemic treatment, according to national guidelines. PATIENTS AND METHODS: Retrospective uni- and multivariate analyses of 57 consecutive female patients treated in the time period 2007-2014 (median follow-up=29 months)...
November 2016: In Vivo
Muthita Hirunsai, Tossaporn Yimlamai, Apichart Suksamrarn
BACKGROUND/AIM: 20-Hydroxyecdystone (20E) is an ecdysteroid hormone which controls molting and reproduction in arthropods. 20E also produces a variety of effects in vertebrates, including enhancing protein synthesis and skeletal muscle regeneration. The effect of 20E on disuse muscle atrophy has not been reported to date. This study examined the proteolytic regulation of 20E in tenotomized rat slow soleus and fast plantaris muscles. MATERIALS AND METHODS: Male Wistar rats were randomly divided into three groups: sedentary control (CON), tenotomy without 20E treatment (TEN), and tenotomy with treatment of 5 mg/kg BW of 20E (TEN+20E)...
November 2016: In Vivo
Gellért Gerencsér, Tímea Varjas, Katalin Szendi, Csaba Varga
Comet assay was used for testing the potential genotoxicity of multi-walled carbon nanotubes after ingestion. Three rat strains were treated through oral gavage with 50 mg/kg/weekly nanoparticles for 90 days. Induced DNA lesions were studied in lymphocytes at 24 and 48 h following the first treatment. This was repeated at the end of the subchronic treatment in lymphocytes as well as peritoneal macrophages. A significant increase in the level of DNA lesions was measured in lymphocytes of Fischer-344 and Long-Evans rats in the first 24 h...
November 2016: In Vivo
Marta Wójcik, Joanna Wessely-Szponder, Halina Cichoż-Lach, Krzysztof Celiński, Ryszard Bobowiec
Macrophages have multiple functions in both inhibiting and promoting hepatocarcinogenesis, which are dependent on their phenotypes. Thus, we were interested in clarifying the 'training' proinflammatory effects exerted by barley β-glucan (BBG) on monocyte-derived macrophages from patients with hepatocellular carcinoma (HCC-Mfs). After isolation and differentiation HCC-Mfs were treated with different concentrations of BBG and functional assays were then conducted after 24 h, and 3 and 5 days of incubation. The release of reactive oxygen species, arginase concentration and cell morphology were analyzed...
November 2016: In Vivo
Mariana M Braz, Maria Cristina Roque-Barreira, Fernando S Ramalho, Carlos A Oliveira, Marlei J Augusto, Leandra N Z Ramalho
ArtinM is a d-mannose-binding lectin found in the seeds of Artocarpus heterophyllus (jackfruit) that interacts with N-glycans, that is associated with receptors on the surface of phagocytic cells and induces the production of inflammatory mediators. Some of them are especially important because they may be required for antitumor immune response. This study aimed to evaluate the effect of ArtinM on hepatocellular preneoplastic foci. Wistar rats received 50 mg/kg of diethyl-nitrosamine (DEN) intraperitoneal weekly for 12 weeks...
November 2016: In Vivo
Seiichi Takeda, Takao Toda, Kazuki Nakamura
We investigated the radical scavenging ability of heparin (HE), medium molecular weight heparinyl phenylalanine (MHF) and medium molecular weight heparinyl leucine (MHL) in the blood of mice. The extracellular superoxide dismutase (EC-SOD) activity was measured according to the method by Oyanagui and Sato. As a result, HE significantly increased the EC-SOD activity with a significant prolongation of activated partial thromboplastin time (APTT), while MHF and MHL significantly increased the EC-SOD activity without a prolongation of APTT...
November 2016: In Vivo
Chul Ho Jang, Cheol Hee Choi, Yong Beom Cho
The aim of this study was to evaluate the synergistic effect of platelet-rich plasma (PRP) and recombinant human bone morphogenic protein (BMP)-2 on accelerated osteogenesis of hydroxyapatite/β-tricalcium phosphate mixture and biphasic calcium phosphate (BCP) in mastoid obliteration. To the best of our knowledge, there have been no studies reporting the enhancing effects of BCP, combined with BMP2 and PRP, on osteogenesis in mastoid obliteration. Mastoid obliteration was performed in a control group (BCP only, n=7), a group treated with BMP2 and BCP (experimental group I, n=7), and a group treated with BMP2, PRP and BCP (experimental group II, n=7)...
November 2016: In Vivo
António Nogueira, Ana Faustino Rocha, Mario Ginja, Paula Alexandra Oliveira, Maria João Pires
AIM: To characterize the kidney alterations associated with renal mass reduction by two-dimensional ultrasound and assess the correlation of the ultrasonographic parameters with the histological and biochemical findings. MATERIALS AND METHODS: Rats were divided into two groups: sham-operated animals (n=13), and animals which underwent renal mass reduction (RMR) through 5/6 nephrectomy (n=14). Renal length, renal thickness, cortical thickness, medullary length and echogenicity of the kidneys were evaluated by ultrasonography at 3 and 6 months after the RMR...
November 2016: In Vivo
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