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Immunohematology

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https://www.readbyqxmd.com/read/28425753/applications-of-selected-cells-in-immunohematology-in-a-developing-country-case-studies
#1
Ravi C Dara, Aseem K Tiwari, Dinesh Arora, Subhasis Mitra, Geet Aggarwal, Devi P Acharya, Gunjan Bhardwaj
When an antibody is detected, its specificity should be determined and its likely clinical significance should be assessed. When one antibody has been identified, it becomes necessary to confirm the presence of additional significant antibodies to ensure that compatible blood is provided to the patient. To perform this confirmation, specific reagent red blood cells (RBCs) are selected; these are called selected cells. Though the most common use of selected cells is for antibody confirmation, they can also be used for several other immunohematologic applications...
January 2017: Immunohematology
https://www.readbyqxmd.com/read/28425752/use-of-standard-laboratory-methods-to-obviate-routine-dithiothreitol-treatment-of-blood-samples-with-daratumumab-interference
#2
Nicholas J Lintel, Debra K Brown, Diane T Schafer, Farai M Tsimba-Chitsva, Scott A Koepsell, Sara M Shunkwiler
Daratumumab is an antibody currently used in the treatment of patients with refractory multiple myeloma. Blood samples from patients being treated with daratumumab may show panreactivity during pre-transfusion testing. To facilitate the provision of blood components for such patients, it is recommended that a baseline phenotype or genotype be established prior to starting treatment with daratumumab. If patient red blood cells (RBCs) require phenotyping after the start of daratumumab treatment, dithiothreitol (DTT) treatment of the patient's RBCs should be performed...
January 2017: Immunohematology
https://www.readbyqxmd.com/read/28425751/development-of-red-blood-cell-autoantibodies-following-treatment-with-checkpoint-inhibitors-a-new-class-of-anti-neoplastic-immunotherapeutic-agents-associated-with-immune-dysregulation
#3
Laura L Cooling, John Sherbeck, Jonathon C Mowers, Sheri L Hugan
Ipilimumab, nivolumab, and pembrolizumab represent a new class of immunotherapeutic drugs for treating patients with advanced cancer. Known as checkpoint inhibitors, these drugs act to upregulate the cellular and humoral immune response to tumor antigens by inhibiting T-cell autoregulation. As a consequence, they can be associated with immune-related adverse events (irAEs) due to loss of self-tolerance, including rare cases of immune-related cytopenias. We performed a retrospective clinical chart review, including serologic, hematology, and chemistry laboratory results, of two patients who developed red blood cell (RBC) autoantibodies during treatment with a checkpoint inhibitor...
January 2017: Immunohematology
https://www.readbyqxmd.com/read/28425750/modeling-alloantibody-formation-to-high-incidence-red-blood-cell-antigens-in-immune-responders-using-genotypic-data
#4
Patricia A R Brunker, Keerthana Ravindran, R S Shirey
Alloimmunization to red blood cell antigens is unpredictable and poorly understood. Patients who are negative for high-incidence antigens (HIAs) are at risk for developing the corresponding antibodies. Molecular methods can easily predict the lack of an antigen and thus, the risk of an individual to become immunized. We examined the prevalence and risk factors for HIA alloimmunization in patients at risk based on genotyping results. Genotyping using a molecular method (HEA BeadChip™, Immucor, Warren, NJ) was performed on all patient specimens referred for molecular testing over 45 months; serologic and clinical data were analyzed...
January 2017: Immunohematology
https://www.readbyqxmd.com/read/28425749/hemolytic-transfusion-reaction-attributable-to-anti-dia
#5
Arthur J Joyce, Kelli M Quantock, Ray Banh, Yew W Liew
In situations when a patient's antibody detection test is negative, many institutions have moved from an indirect antiglobulin test (IAT) crossmatch to an electronic crossmatch system. Here we report a case of an acute hemolytic transfusion reaction attributable to anti-Dia in a patient with a negative antibody detection test. A 22-year-old female patient with a diagnosis of β thalassemia and sickle cell anemia commenced a routine exchange transfusion of 5 units of red blood cells (RBCs) in the apheresis unit as part of her regular treatment...
January 2017: Immunohematology
https://www.readbyqxmd.com/read/28425748/a-field-analysis-trial-comparing-the-turnaround-times-of-routine-and-stat-red-blood-cell-immunohematology-testing
#6
COMPARATIVE STUDY
Katie Sackett, Andrea Kjell, Abigail M Schneider, Claudia S Cohn
The turnaround time (TAT) for pre-transfusion testing is important for prompt clinical decision-making. TAT includes the time between the arrival of the sample and the initiation of testing, plus the processing time (PT) required to generate and report a result. The TAT in larger blood banks is mostly dependent upon the capability of the analyzer used. In smaller blood banks, where manual work is often performed, the TAT is dependent on availability and experience of staff, testing resources, and workload. Our site performed a comparative analysis of the ORTHO VISION® (Ortho Clinical Diagnostics, Raritan, NJ) and the Echo® (Immucor, Norcross, GA) blood bank analyzers, using the TAT and PT of standard blood bank tests as the outcome metrics...
January 2017: Immunohematology
https://www.readbyqxmd.com/read/28257231/trends-of-abo-and-rh-phenotypes-in-transfusion-dependent-patients-in-pakistan
#7
Nida Anwar, Munira Borhany, Saqib Ansari, Sana Khurram, Uzma Zaidi, Imran Naseer, Muhammad Nadeem, Tahir Shamsi
No abstract text is available yet for this article.
December 2016: Immunohematology
https://www.readbyqxmd.com/read/28257230/a-detailed-flow-cytometric-method-for-detection-of-low-level-in-vivo-red-blood-cell-bound-igg-iga-and-igm
#8
Wendy Beres, Geralyn M Meny, Sandra Nance
No abstract text is available yet for this article.
December 2016: Immunohematology
https://www.readbyqxmd.com/read/28257229/human-platelet-antigen-allelic-diversity-in-peninsular-malaysia
#9
Wan Ubaidillah W Syafawati, Zulkafli Zefarina, Zafarina Zafarina, Mohd Nazri Hassan, Mohd Nor Norazmi, Sundararajulu Panneerchelvam, Geoffrey K Chambers, Hisham Atan Edinur
No abstract text is available yet for this article.
December 2016: Immunohematology
https://www.readbyqxmd.com/read/28257228/acute-hemolytic-transfusion-reaction-attributed-to-anti-ata
#10
Jay S Raval, Sarah K Harm, Bethann Wagner, Darrell J Triulzi, Mark H Yazer
No abstract text is available yet for this article.
December 2016: Immunohematology
https://www.readbyqxmd.com/read/28257227/distribution-of-blood-groups-in-the-iranian-general-population
#11
Ehsan Shahverdi, Mostafa Moghaddam, Ali Talebian, Hassan Abolghasemi
No abstract text is available yet for this article.
December 2016: Immunohematology
https://www.readbyqxmd.com/read/27834485/the-h-blood-group-system
#12
Erwin A Scharberg, Coral Olsen, Peter Bugert
The H blood group system, ISBT symbol H (018), consists of a single antigen (H) defined by a terminal fucose residue found on red blood cells and in secretions formed by the action of α-1,2-fucosyltransferases 1 (α2FucT1) and 2 (α2FucT2), respectively. Mutant alleles of the corresponding FUT1 and FUT2 genes result in either a H– phenotype (Bombay phenotype, Oh) or a weak H phenotype (para-Bombay, H+w). In addition, the FUT2 gene is the molecular basis of the secretor (Se) status, and homozygosity or compound heterozygosity for null alleles is associated with the nonsecretor (se) status...
September 2016: Immunohematology
https://www.readbyqxmd.com/read/27834484/laboratory-management-of-perinatal-patients-with-apparently-new-anti-d
#13
Judith L Hannon, Gwen Clarke
Despite the existence of long-standing, well-organized programs for Rh immune globulin (RhIG) prophylaxis, immune anti-D continues to be detected in the D– perinatal population. Between 2006 and 2008, 91 prenatal patients, found to have a previously unidentified anti-D, were followed up with a survey to their treating physician and with additional serologic testing where possible. The physician survey requested pregnancy and RhIG history information, including recent or distant potential alloimmunizing events, and the physicians were asked their opinion on the likely cause for the anti-D...
September 2016: Immunohematology
https://www.readbyqxmd.com/read/27834483/autoanti-c-in-a-patient-with-primary-sclerosing-cholangitis-and-autoimmune-hemolytic-anemia-a-rare-presentation
#14
Meenu Bajpai, Ashish Maheshwari, Shruti Gupta, Chhagan Bihari
Primary sclerosing cholangitis (PSC) is rarely associated with autoimmune hemolytic anemia (AIHA), and the presence of specific autoantibodies has not been reported previously. We present a unique case report of PSC associated with AIHA implicating autoanti-C. A 17-year-old girl was admitted to our hospital with PSC along with AIHA. Her blood sample demonstrated a positive direct antiglobulin test and a positive autocontrol in the antihuman globulin phase, confirming the patient had warm-reactive AIHA. Further testing showed the possibility of anti-C...
September 2016: Immunohematology
https://www.readbyqxmd.com/read/27834482/the-augustine-blood-group-system-48-years-in-the-making
#15
Geoffrey Daniels
The high-prevalence antigen, Ata, was first identified in 1967, but it was not until 2015 that Ata became AUG1 of a new blood group system, Augustine (AUG). The new system was established after the identification of the gene encoding Ata and the recognition of a null phenotype (AUG:–1,–2) in an At(a–) patient with an antibody (anti-AUG2) reactive with At(a–) red blood cells. The At(a–) phenotype is very rare and, with the exception of the one family with the null phenotype, has only been found in individuals of African origin...
September 2016: Immunohematology
https://www.readbyqxmd.com/read/27834481/how-to-recognize-and-resolve-reagent-dependent-reactivity-a-review
#16
Gavin C Patch, Charles F Hutchinson, Nancy A Lang, Ghada Khalife
Reagent-dependent reactivity can be described as agglutination of red blood cells (RBCs) in serologic testing that is not related to the interaction of RBC antigens and antibodies that the test system is intended to detect. In other words, reagent-dependent reactivity results in false-positive agglutination reactions in serologic testing. These false-positive reactions can cause confusion in antigen typing and RBC antibody detection and identification procedures, and may result in delays in patient transfusion...
September 2016: Immunohematology
https://www.readbyqxmd.com/read/27834480/a-caucasian-jk-a-jk-b-woman-with-jk-a-b-red-blood-cells-anti-jkb-and-a-novel-jk-b-allele-c-1038delg
#17
Glenn Ramsey, Ricardo D Sumugod, Paul F Lindholm, Jules G Zinni, Jessica A Keller, Trina Horn, Margaret A Keller
The Kidd blood group on the red blood cell (RBC) glycoprotein urea transporter-B has a growing number of weak and null alleles in its gene SLC14A1 that are emerging from more widespread genotyping of blood donors and patients. We investigated a 64-year-old Caucasian woman of Polish-Czech descent who developed anti-Jkb detected in solid-phase RBC adherence testing within 12 days after 7 units of RBCs were transfused. Her RBCs subsequently typed Jk(a+b–) by licensed reagents and human antisera. Nevertheless, in RBC genotyping (BioArray HEA BeadChip, Immucor, Warren, NJ) performed in our transfusion service on all patients with alloantibodies, her Kidd typing was JK*A/JK*B based on the Jka/Jkb single nucleotide polymorphism in exon 9 (c...
September 2016: Immunohematology
https://www.readbyqxmd.com/read/27901574/miracles-do-happen-meeting-the-challenges-of-providing-rare-blood-through-the-american-rare-donor-program
#18
Cynthia Flickinger
No abstract text is available yet for this article.
June 2016: Immunohematology
https://www.readbyqxmd.com/read/27901573/the-american-rare-donor-program
#19
REVIEW
Cynthia Flickinger
No abstract text is available yet for this article.
June 2016: Immunohematology
https://www.readbyqxmd.com/read/27901572/the-united-kingdom-national-rare-donor-panel
#20
REVIEW
Nicole M Thornton
No abstract text is available yet for this article.
June 2016: Immunohematology
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