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Journal of Geriatric Psychiatry and Neurology

Patrick M Flanigan, Mitra A Khosravi, James B Leverenz, Babak Tousi
OBJECTIVE: Dementia with Lewy bodies (DLB) is frequently misdiagnosed for Alzheimer dementia (AD), especially in its earlier stages. We characterized color vision impairment (CVI) in patients with DLB versus patients with AD to determine its usefulness in improving accuracy of early diagnosis. METHODS: We retrospectively reviewed charts of patients with AD, DLB, and patients with mild cognitive impairment suspected to be in the prodromal phase of DLB (pro-DLB) or prodromal phase of AD (pro-AD)...
March 2018: Journal of Geriatric Psychiatry and Neurology
Nathália R S Kimura, Maria Alice T Baptista, Raquel L Santos, Maria da Gloria Portugal, Aud Johannenssen, Maria L Barca, Knut Engedal, Jerson Laks, José Pedro Simões, Valeska Marinho Rodrigues, Marcia C N Dourado
BACKGROUND: Quality of life (QoL) is a growing area of interest in dementia research. This study aims to investigate the caregivers' perspective about the QoL of people with young-onset Alzheimer disease (YOAD) and late-onset Alzheimer disease (LOAD). We also aim to investigate factors that might be associated to caregivers' perspective in YOAD and LOAD. METHODS: We included 110 people with Alzheimer disease (PwAD; 53 YOAD) and their primary caregivers. The PwAD completed assessments about their QoL and cognition...
March 2018: Journal of Geriatric Psychiatry and Neurology
Juliana Hack, Daphne Eschbach, Rene Aigner, Ludwig Oberkircher, Steffen Ruchholtz, Christopher Bliemel, Benjamin Buecking
OBJECTIVE: The aim of this study was to identify factors that are associated with cognitive decline in the long-term follow-up after hip fractures in previously nondemented patients. METHODS: A consecutive series of 402 patients with hip fractures admitted to our university hospital were analyzed. After exclusion of all patients with preexisting dementia, 266 patients were included, of which 188 could be examined 6 months after surgery. Additional to several demographic data, cognitive ability was assessed using the Mini-Mental State Examination (MMSE)...
March 2018: Journal of Geriatric Psychiatry and Neurology
Manuel E Machado-Duque, Juan Pablo Castaño-Montoya, Diego A Medina-Morales, Alejandro Castro-Rodríguez, Alexandra González-Montoya, Jorge E Machado-Alba
BACKGROUND/OBJECTIVE: To determine the association between the use of anticholinergic drugs and the risk of falls with hip fracture in a population older than 60 years. METHODS: A case-control study in patients older than 60 years with a diagnosis of hip fracture. All drugs dispensed during the previous 30 days were identified. Sociodemographic, clinical, pharmacological (drugs according to the Anticholinergic Risk Scale [ARS]), and polypharmacy variables were analyzed...
March 2018: Journal of Geriatric Psychiatry and Neurology
Martinus P G Broen, A F G Leentjens, J T Hinkle, A J H Moonen, M L Kuijf, N M Fischer, K Perepezko, A Bakker, G M Pontone
OBJECTIVE: The aim of this work was to investigate marker profiles for proposed anxiety subtypes in Parkinson disease (PD). METHODS: We used the persistent anxiety, episodic anxiety, and avoidance behavior subscales of the Parkinson Anxiety Scale as dependent variables in multivariable linear regression analyses using a cross-sectional data set of 311 patients with PD. Independent variables consisted of a range of demographic, psychiatric, and disease-specific markers...
March 2018: Journal of Geriatric Psychiatry and Neurology
Silvio Peluso, Anna De Rosa, Natascia De Lucia, Antonella Antenora, Maddalena Illario, Marcello Esposito, Giuseppe De Michele
Animal-assisted therapy (AAT) includes a set of nonpharmacological interventions aimed at improving human health through the use of trained or untrained animals. In recent decades, AAT has been trialed for different neurological and psychiatric disorders. In patients with dementia, interaction with animals seems to have a positive influence on aggressiveness and anxiety and to ameliorate quality of life and relationship skills. In psychiatric patients, AAT seems to increase motivation and self-esteem, improve prosocial conduct, and decrease behavioral problems...
January 1, 2018: Journal of Geriatric Psychiatry and Neurology
Sarah Pillemer, George D Papandonatos, Cara Crook, Brian R Ott, Geoffrey Tremont
OBJECTIVE: This study aimed to compare the sensitivity and specificity of a modified version of the Minnesota Cognitive Acuity Screen (MCAS-m), by adding learning and recognition memory components, to the original version MCAS to distinguish amnestic mild cognitive impairment (aMCI) from healthy controls (HCs). METHODS/DESIGN: A total of 30 individuals with aMCI and 30 HCs underwent neuropsychological testing, neurologic examination, laboratory, and brain imaging tests...
January 1, 2018: Journal of Geriatric Psychiatry and Neurology
Diana Duro, Miguel Tábuas-Pereira, Sandra Freitas, Beatriz Santiago, Maria Amália Botelho, Isabel Santana
The Clock Drawing Test (CDT) has a known potential for the detection of cognitive impairment in populations with dementia, especially Alzheimer disease (AD). Our aim was to compare the clinical utility of 3 CDT scoring systems (Rouleau, Cahn, and Babins) in several pathologies with cognitive compromise from a tertiary center memory clinic. We selected patients with a clinical diagnosis of mild stage AD, behavioral variant frontotemporal dementia (FTD), vascular dementia (VaD), dementia with Lewy bodies (DLB), and Parkinson disease with dementia (PDD)...
January 1, 2018: Journal of Geriatric Psychiatry and Neurology
Giulia Grande, Davide Liborio Vetrano, Ilaria Cova, Simone Pomati, Daniele Mattavelli, Laura Maggiore, Valentina Cucumo, Roberta Ghiretti, Nicola Vanacore, Claudio Mariani, Debora Rizzuto
INTRODUCTION: Social isolation and living alone have been associated with negative outcomes, especially in the older population. We aim to investigate the effect of living alone on the development of dementia in people with mild cognitive impairment (MCI). MATERIALS AND METHODS: In this longitudinal study, we enrolled 345 outpatients with MCI evaluated at baseline through a clinical and neuropsychological protocol. Data on living situation (living alone vs. living with someone) were also collected...
January 1, 2018: Journal of Geriatric Psychiatry and Neurology
(no author information available yet)
Narayan SW, Jamieson HA, Nishtala PS. Evaluation of the National Minimum Data Set for Neurological Conditions in Older Adults. Journal of Geriatric Psychiatry and Neurology. 2017; 30(6):331-336. doi: 10.1177/0891988717732154 In the above-referenced article, the corresponding author's qualifications were incorrectly listed as BPharm, MPharm, PG DipClinPharm, PhD which is an overlap of another author's qualifications. The online and print versions have been updated to reflect the correct qualification of the corresponding author as BPharm, MPharmPrac...
January 1, 2018: Journal of Geriatric Psychiatry and Neurology
Martine Paquette, Yascara Grisel Luna Saavedra, Judes Poirier, Louise Théroux, Doris Dea, Alexis Baass, Robert Dufour
BACKGROUND: Hypercholesterolemia is a major risk factor for the late-onset form of Alzheimer disease (AD). Loss-of-function (LOF) mutations of PCSK9 and PCSK9 inhibitors lower low-density lipoprotein cholesterol (LDL-C) and have been associated with a reduced risk of cardiovascular disease. The aim of this study was to examine the effect of PCSK9 LOF variants on risk and age of onset of AD. METHODS: A total of 878 participants (410 controls and 468 AD cases) from the Quebec Founder Population were included in the study...
January 1, 2018: Journal of Geriatric Psychiatry and Neurology
Xin Xu, Cheuk Ni Kan, Tien Yin Wong, Ching-Yu Cheng, M Kamran Ikram, Christopher Li-Hsian Chen, Narayanaswamy Venketasubramanian
OBJECTIVE: Sleep disturbances were found to be associated with more behavioral and psychological symptoms (BPS) in early patients with Alzheimer's disease (AD). However, data on preclinical stages of dementia are lacking. Hence, the present study sought to investigate the association between sleep disturbances and BPS in dementia-free elderly with varying severity of cognitive impairment in an Asian sample. METHODS: Community-living elderly were recruited and administered a comprehensive cognitive battery (vascular dementia battery [VDB]) and the Neuropsychiatric Inventory to assess symptoms of sleep disturbances and BPS...
January 1, 2018: Journal of Geriatric Psychiatry and Neurology
Panagiota Voskou, Athanasios Douzenis, Alexandra Economou, Sokratis G Papageorgiou
INTRODUCTION: The increase in the aging population and the number of patients with dementia led to the research in older adults' capacity assessment over the last 3 decades. Many cases of contested wills occur due to lack of testamentary capacity (TC), especially in cases of dementia. AIM: Purpose of the present study was to overview the legal, medical, and neuropsychological aspects of TC as well as the instruments used for TC assessment. FINDINGS: The testator/testatrix with intact TC has realistic perception of his or her property value, lack of psychopathology affecting contact with reality, and intact intention of how and to whom he or she will dispose his or her assets...
January 2018: Journal of Geriatric Psychiatry and Neurology
Natalie J Sachs-Ericsson, Greg Hajcak, Julia L Sheffler, Ian H Stanley, Edward A Selby, Guy G Potter, David C Steffens
BACKGROUND: Individuals with major depressive disorder (MDD) may exhibit smaller striatal volumes reflecting deficits in the reward circuit. Deficits may change with age and be more pronounced among the melancholic subtype. Limited research has investigated striatal volume differences in older adults and by depression subtypes. METHOD: We used baseline data from the Neurocognitive Outcomes of Depression in the Elderly study. We examined volumetric differences in the putamen and caudate nucleus among older adults (60 years and older), comparing healthy control participants (n = 134) to depressed participants (n = 226), and comparing nonmelancholic depressed participants (n = 93) to melancholic depressed participants (n = 133)...
January 2018: Journal of Geriatric Psychiatry and Neurology
D Santos-García, E Suárez-Castro, J Ernandez, I Expósito-Ruiz, C Tuñas-Gesto, M Aneiros-Díaz, T de Deus-Fonticoba, M López-Fernández, D Núñez-Arias
BACKGROUND AND OBJECTIVE: The aim of this study is to identify risk factors for mortality in a community-based cohort of nondemented patients with Parkinson disease (PD) during prospective long-term follow-up, while also comparing the effect of motor complications to nonmotor symptoms (NMS) on risk of mortality. METHODS: One hundred forty seven nondemented patients with PD (57.1% males; 70.9 ± 8.6 years old) were included in this 48 month follow-up, longitudinal, single, evaluation study...
January 2018: Journal of Geriatric Psychiatry and Neurology
Tatiana Belfort, Pedro Simões, Maria Fernanda Barroso de Sousa, Raquel Luiza Santos, Isabel Barbeito, Bianca Torres, Marcia Cristina N Dourado
A large body of evidence highlights the social cognitive impairment in neurodegenerative diseases such Alzheimer disease (AD). This study investigated the relationship among social and emotional functioning (SEF), awareness of disease, and other clinical aspects in people with AD (PwAD). A consecutive series of 50 people with mild to moderate AD and their 50 family caregivers were assessed. There was a significant difference between self-rated SEF and informant-rated SEF. In 56% of PwAD, self-rated SEF is lower than informant-rated SEF...
January 2018: Journal of Geriatric Psychiatry and Neurology
Ibrahim Abdollahpour, Saharnaz Nedjat, Yahya Salimi
BACKGROUND: Now positive aspect of caregiving (PAC) is well-defined as caregiver gains, satisfaction, meaningful life, and enhanced family relationship. The adjusted association of PAC and caregiver burden is not well acknowledged. This study investigated the association of caregiver burden and PAC adjusting for potential confounders. METHODS: This was a cross-sectional study that recruited 132 caregivers. A linear regression model with PAC was used to estimate the adjusted associations...
January 2018: Journal of Geriatric Psychiatry and Neurology
Renee J Flores, Adalberto Campo-Arias, Jim P Stimpson, Claudia M Chalela, Carlos A Reyes-Ortiz
To explore the association between past sexual abuse and depression in elders living in Bogotá, Colombia, we used data from the SABE (Salud, Bienestar y Envejecimiento [Health, Well-being, and Aging]) Bogotá Study. Participants were 2000 community-dwelling adults aged 60 years and older in 2012. Sexual abuse was assessed by self-report. Depression was measured by the Geriatric Depression Scale. The weighted prevalence estimate was 2.6% for past sexual abuse and 23.4% for depression. Multivariate data analyses showed significantly higher odds of depression for past sexual abuse (odds ratio [OR] = 3...
January 2018: Journal of Geriatric Psychiatry and Neurology
Sevdenur Cizginer, Edward Marcantonio, Sarinnapha Vasunilashorn, Alvaro Pascual-Leone, Mouhsin Shafi, Eva M Schmitt, Sharon K Inouye, Richard N Jones
We evaluated the role of cognitive and brain reserve markers in modifying the risk of postoperative delirium associated with a pathophysiologic marker. The Successful Aging after Elective Surgery study (SAGES) enrolled 556 adults age ≥70 years without dementia scheduled for major surgery. Patients were assessed preoperatively and daily during hospitalization for delirium. We used C-reactive protein (CRP) as a pathophysiologic marker of inflammation, previously associated with delirium. Markers of reserve included vocabulary knowledge, education, cognitive activities, occupation type and complexity, head circumference, intracranial volume, and leisure activities...
November 2017: Journal of Geriatric Psychiatry and Neurology
Raphael Breder, Marco Antonio Araujo Leite, Jony Arrais Pinto, Igor Pinto Cavalcante, Bruno Lima Pessoa, Marco Antônio Orsini Neves
INTRODUCTION: Recent publications have highlighted the low sensitivity of the Mini-Mental State Examination (MMSE) for the cognitive assessment of patients with Parkinson disease (PD). The Montreal Cognitive Assessment (MoCA), otherwise, has shown greater sensitivity when compared to the MMSE. Based on this, we have searched for the cognitive impairment measurable by the MoCA and the functional performance on activities of daily living in a sample of Brazilian patients with PD and normal MMSE...
November 2017: Journal of Geriatric Psychiatry and Neurology
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