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Journal of Geriatric Psychiatry and Neurology

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https://www.readbyqxmd.com/read/28639878/exploring-the-phenotype-in-mild-cognitive-impairment-to-aid-the-prediction-of-those-at-risk-of-transitioning-to-parkinson-disease-and-dementia-with-lewy-bodies
#1
Jennifer Y Y Szeto, Glenda M Halliday, Sharon L Naismith, Simon J G Lewis
To date, only limited research has concurrently investigated the presence of rapid eye movement sleep behavior disorder (RBD) and other features associated with Parkinson disease (PD) and dementia with Lewy bodies (DLB) in people presenting with mild cognitive impairment (MCI). As a first step towards a longitudinal research project, the present study explored the relationships between MCI, RBD, and depression in 108 older adults who presented with subjective memory complaints but were not known to have a neurodegenerative condition...
July 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28639877/mild-cognitive-impairment-and-changes-in-everyday-function-over-time-the-importance-of-evaluating-both-speed-and-accuracy
#2
Caroline L Lassen-Greene, Kayla Steward, Ozioma Okonkwo, Ellen Porter, Michael Crowe, David E Vance, H Randall Griffith, Karlene Ball, Daniel C Marson, Virginia G Wadley
OBJECTIVES: Research estimates that a significant percentage of individuals with mild cognitive impairment (MCI) experience functional difficulties. In addition to reduced accuracy on measures of everyday function, cross-sectional research has demonstrated that speed of performing instrumental activities of daily living (IADLs) is slowed in individuals with MCI. The present study investigated whether baseline and longitudinal changes in speed and accuracy of IADL performance differed between persons with MCI and cognitively normal peers...
July 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28639876/meta-analysis-of-social-cognition-in-mild-cognitive-impairment
#3
Emre Bora, Görsev G Yener
Social cognitive abilities are impaired in Alzheimer disease and other dementias. Recent studies suggested that social cognitive abilities might be also impaired in mild cognitive impairment (MCI). Current meta-analysis aimed to summarize available evidence for deficits in theory of mind (ToM) and emotion recognition in MCI. In this meta-analysis of 17 studies, facial emotion recognition and ToM performances of 513 individuals with MCI and 693 healthy controls were compared. Mild cognitive impairment was associated with significant impairments falling in the medium effect sizes range in ToM ( d = 0...
July 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28553757/motor-disturbances-in-elderly-medical-inpatients-and-their-relationship-to-delirium
#4
Dimitrios Adamis, Geraldine McCarthy, Edmond O'Mahony, David Meagher
Motor disturbances in delirious patients are common, but their relationship to cognition and severity of illness has not been studied. We examined motor subtypes in an older age inpatient population, their relationship to clinical variables including delirium, and their association with 1-year mortality in a prospective study, using the Confusion Assessment Method, Acute Physiology and Chronic Health Evaluation II, Montreal Cognitive Assessment (MoCA), Barthel Index, and Delirium Rating Scale-Revised 98 (DRS-R98)...
July 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28421897/negative-bias-in-the-perception-and-memory-of-emotional-information-in-alzheimer-disease
#5
Gomez-Gallego Maria, Gomez-Garcia Juan
BACKGROUND: There is some controversy about the ability of patients with Alzheimer disease (AD) to experience and remember emotional stimuli. This study aims to assess the emotional experience of patients with AD and the existence of emotional enhancement of memory. We also investigated the influence of affective state on these processes. METHODS: Sixty pictures from the International Affective Picture System were administered to 106 participants (72 patients with AD and 54 controls)...
May 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28421896/anosognosia-and-its-relation-to-psychiatric-symptoms-in-early-onset-alzheimer-disease
#6
MULTICENTER STUDY
Bora Yoon, Yong S Shim, Yun Jeong Hong, Seong Hye Choi, Hee Kyung Park, Sun Ah Park, Jee Hyang Jeong, Soo Jin Yoon, Dong-Won Yang
BACKGROUND: We investigated differences in the prevalence of anosognosia and neuropsychiatric symptoms (NPSs) characteristics according to disease severity in patients with early-onset Alzheimer disease (EOAD). METHODS: We recruited 616 patients with EOAD. We subdivided participants into 2 groups based on the presence or absence of anosognosia and then again by Clinical Dementia Rating (CDR) scale. We compared the differences in the Neuropsychiatric Inventory (NPI) scores according to anosognosia and disease severity...
May 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28355946/dysexecutive-symptoms-in-primary-progressive-aphasia-beyond-diagnostic-criteria
#7
Joël Macoir, Monica Lavoie, Robert Laforce, Simona M Brambati, Maximiliano A Wilson
Primary progressive aphasia (PPA) is a heterogeneous neurodegenerative condition in which the most prominent clinical feature is language difficulties. Other cognitive domains have been described to remain unaffected at the early stages of the disease and, therefore, excluded from diagnostic criteria. However, we show in this article that executive function (EF) disorders may be present in the 3 variants (nonfluent/agrammatic, logopenic, and semantic) of PPA. We also illustrate changes in language and EF by means of a 3-year behavioral and neuroimaging longitudinal study of a patient suffering from the semantic variant of PPA...
May 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28355945/late-life-depression-modifications-of-brain-resting-state-activity
#8
Filippo Cieri, Roberto Esposito, Nicoletta Cera, Valentina Pieramico, Armando Tartaro, Massimo di Giannantonio
Late-life depression (LLD) is a common emotional and mental disability in the elderly population characterized by the presence of depressed mood, the loss of interest or pleasure in daily activities, and other depression symptoms. It has a serious effect on the quality of life of elderly individuals and increases their risk of developing physical and mental diseases. It is an important area of research, given the growing elderly population. Brain functional connectivity modifications represent one of the neurobiological biomarker for LLD even if to date remains poorly understood...
May 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28351200/diagnostic-accuracy-and-confidence-in-the-clinical-detection-of-cognitive-impairment-in-early-stage-parkinson-disease
#9
Kathryn A Wyman-Chick, Phillip K Martin, Matthew J Barrett, Carol A Manning, Scott A Sperling
BACKGROUND/AIMS: Mild cognitive impairment (MCI) is present in up to 34% of patients with early-stage Parkinson disease (PD); however, it is difficult to detect subtle impairment without objective cognitive testing. METHODS: Data were obtained from the Parkinson Progression Marker Initiative. All 341 participants were administered the Montreal Cognitive Assessment (MoCA) and a brief neuropsychological battery. Participants were classified as PD-MCI if MoCA was <26 or if they scored ≥1 standard deviation below the normative mean in 2 or more domains, based upon established criteria...
May 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28351199/pharmacological-management-of-psychiatric-symptoms-in-frontotemporal-dementia-a-systematic-review
#10
REVIEW
Massimiliano Buoli, Marta Serati, Alice Caldiroli, Daniela Galimberti, Elio Scarpini, Alfredo Carlo Altamura
Psychiatric symptoms in patients with frontotemporal dementia (FTD) are highly prevalent and may complicate clinical management of these patients. Purpose of the present article is to present and discuss available data about the pharmacological treatment of psychiatric symptoms in patients with FTD. A research in the main database sources has been conducted to obtain an overview of the pharmacological management of psychiatric symptoms in patients with FTD. The search strategy included the following terms-"FTD and psychiatry," "FTD and behavioural disturbances," and "FTD and treatment"...
May 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28077010/positive-aspects-of-caregiving-questionnaire
#11
Ibrahim Abdollahpour, Saharnaz Nedjat, Maryam Noroozian, Yahya Salimi, Reza Majdzadeh
OBJECTIVE: The potential role of positive aspects of caregiving in enhancing caregivers' health is an important issue. The aim of this study was to develop and validate Positive Aspects of Caregiving Questionnaire (PACQ) in caregivers of patients with dementia in Iran. METHODS: Content validation process was used to content valid development. Cronbach α and intraclass correlation coefficient (ICC) were calculated as reliability indices. We used exploratory factor analysis to extract potential latent factors and evaluate the factor structure of PACQ...
March 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28077009/cognitive-decline-body-mass-index-and-waist-circumference-in-community-dwelling-elderly-participants
#12
Jorge Mario Rodríguez-Fernández, Emily Danies, José Martínez-Ortega, William C Chen
OBJECTIVE: The aim of this study was to explore the association of body mass index (BMI), waist circumference (WC), and BMI and WC changes over time with cognitive decline in a nationally representative sample. METHODS: A total of 5239 participants (≥65 years) were followed for 3 years as part of the National Health and Aging Trends Study. Cox proportional hazard regression was applied to model the risk of cognitive decline. RESULTS: BMI, after adjusting for WC and main confounders, was associated with reduced risk of cognitive decline (hazard ratio [HR] 0...
March 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28073327/nonmotor-symptoms-in-parkinson-disease-a-descriptive-review-on-social-cognition-ability
#13
REVIEW
Rosanna Palmeri, Viviana Lo Buono, Francesco Corallo, Maria Foti, Giuseppe Di Lorenzo, Placido Bramanti, Silvia Marino
Parkinson disease (PD) is a neurodegenerative disorder characterized by motor and nonmotor symptoms. Nonmotor symptoms include cognitive deficits and impairment in emotions recognition ability associated with loss of dopaminergic neurons in the substantia nigra and with alteration in frontostriatal circuits. In this review, we analyzed the studies on social cognition ability in patients with PD. We searched on PubMed and Web of Science databases and screening references of included studied and review articles for additional citations...
March 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28073326/hierarchical-decline-of-the-initiative-and-performance-of-complex-activities-of-daily-living-in-dementia
#14
Clarissa M Giebel, Caroline Sutcliffe, David Challis
OBJECTIVES: While basic activities of daily living hierarchically decline in dementia, little is known about the decline of individual instrumental activities of daily living (IADLs). The objective of this study was to assess initiative and performance deficits in IADLs in dementia. METHODS: A total of 581 carers completed the revised Interview for Deterioration in Daily Living Activities in Dementia 2 to rate their relative's everyday functioning. RESULTS: Initiating and performing IADLs deteriorated hierarchically, while people with dementia were consistently most impaired in initiating using the computer and managing finances...
March 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28073325/the-moderating-role-of-insulin-like-growth-factor-1-in-the-relationship-between-cognitive-and-aerobic-endurance-change
#15
Jason R Anderson, Dayana Calvo, Ellen Glickman, John Gunstad, Mary Beth Spitznagel
BACKGROUND: Improvements in cognition often accompany fitness improvements in older adults, and research suggests insulin-like growth factor 1 (IGF-1) may influence this association. No prior work has examined this in mild cognitive impairment (MCI). We predicted that IGF-1 would moderate the relationship between cognition and aerobic endurance improvement, such that greater baseline IGF-1 would accompany a stronger relationship between cognition and aerobic endurance change. METHOD: Twenty-seven individuals with MCI completed assessments of aerobic endurance (2-minute step test [2MST]) and global cognition (Modified Mini-Mental State [3MS]) before and after a 6-month period of twice-weekly exercise...
March 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28067106/retrospective-neuropsychological-profile-of-patients-with-parkinson-disease-prior-to-developing-visual-hallucinations
#16
Alana J Muller, Claire O'Callaghan, Courtney C Walton, James M Shine, Simon J G Lewis
Visual hallucinations (VH) are a common feature of Parkinson disease (PD); however, the cognitive profile preceding the onset of VH has not yet been established. The present study investigated longitudinal neuropsychological performance of patients with PD who developed VH during follow-up compared to a group who did not develop VH. The patient groups were matched for demographic and disease severity variables at their baseline assessments. Patients who developed VH displayed impaired performance at baseline on measures of psychomotor speed, executive functioning, reaction time, and attention compared to patients who did not develop VH...
March 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28013571/short-montreal-cognitive-assessment
#17
A J Larner
The diagnostic accuracy of the short Montreal Cognitive Assessment (s-MoCA), a cognitive screening instrument recently derived by item response theory and computerized adaptive testing from the original MoCA, for the diagnosis of dementia and mild cognitive impairment (MCI) was assessed in 2 patient cohorts referred to a dedicated memory clinic in order to examine the validity and reproducibility of s-MoCA. Diagnosis used standard clinical diagnostic criteria for dementia and MCI as reference standard (prevalence of cognitive impairment = 0...
March 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28747137/modified-pfeffer-questionnaire-for-functional-assessment-in-parkinson-disease
#18
Kelson James Almeida, Lívio Pereira de Macêdo, Janine Lemos de Melo Lobo Jofili Lopes, Edson Bor-Seng-Shu, Raimundo Nonato Campos-Sousa, Egberto Reis Barbosa
INTRODUCTION: It was proposed to modify the Pfeffer questionnaire (PQ) for functional assessment in patients with Parkinson disease (PD). AIM: To determine the cutoff score for diagnosis of functional impairment in patients with PD by modified PQ (mPQ). METHODS: A total of 110 patients with PD were enrolled into the study, and a neuropsychological test battery was performed to assess their cognitive status. Regarding functional assessment, the mPQ has been applied, and their results were compared to the functional assessment by Informant Questionnaire on Cognitive Decline in the Elderly adapted for use in Brazil (IQCODE-BR)...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28747136/the-relationship-between-apolipoprotein-%C3%AE%C2%B54-carrier-status-and-sleep-characteristics-in-cognitively-normal-older-adults
#19
Melike Kahya, Eric Vidoni, Jeffrey M Burns, Ashley N Thompson, Kayla Meyer, Catherine F Siengsukon
The apolipoprotein (APOE) ε4 allele, a well-described genetic risk factor for late-onset Alzheimer disease (AD), is associated with sleep disturbances even in cognitively normal older adults, although it is not clear whether this association is independent of sleep apnea. We sought to extend previous studies by examining whether cognitively normal older adults without self-reported sleep apnea who carry the APOE ε4 allele have altered sleep characteristics compared to noncarriers. Data from N = 36 (APOE ε4 carriers [n = 9], noncarriers [n = 27]) cognitively normal older adults (Clinical Dementia Rating [CDR] scale = 0) without self-reported sleep apnea were used for these analyses...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28747135/high-burden-and-depression-among-late-stage-idiopathic-parkinson-disease-and-progressive-supranuclear-palsy-caregivers
#20
Christian Schmotz, Carmen Richinger, Stefan Lorenzl
OBJECTIVES: Caregivers of patients with late-stage idiopathic Parkinson disease (IPD) and late-stage progressive supranuclear palsy (PSP) often suffer from severe psychological strain themselves. This study investigates the influence of the different kind of symptoms in IPD and PSP on the psychological burden of the caregivers. METHODS: Twenty patients with late-stage IPD and 20 patients with late-stage PSP and their caregivers were investigated. To measure the degree of motor, cognitive, and affective impairment of the patients, the instruments Subscale III of the Unified Rating Scale for Parkinsonism (UPDRS-III), a shortened 24-item version of the Mini-Mental State Examination, and the Geriatric Depression Scale (GDS-30) were used...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
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