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Mycoses

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https://www.readbyqxmd.com/read/28508389/usefulness-of-techniques-based-on-real-time-pcr-for-the-identification-of-onychomycosis-causing-species
#1
Anissa Z Hafirassou, Clara Valero, Nadia Gassem, Ilhem Mihoubi, Maria J Buitrago
Onychomycosis (OM) is a nail infection caused mainly by dermatophyte species but other species of yeast and moulds are frequently involved as well. Classical diagnosis has limitations thus empirical treatment is common. The usefulness of different real time PCR (RT-PCR) assays for identifying species causing OM was assessed in samples from seventy patients and fifteen controls. Conventional methods and four different RT-PCR assays were used: a panfungal, a pandermatophyte and two specific assays for detecting Candida spp...
May 16, 2017: Mycoses
https://www.readbyqxmd.com/read/28504471/scedosporium-apiospermum-complex-in-cystic-fibrosis-should-we-treat
#2
Maria Noni, Anna Katelari, Aikaterini Kapi, Angeliki Stathi, George Dimopoulos, Stavros-Eleftherios Doudounakis
Species of the Scedosporium apiospermum complex are the second most frequent filamentous fungi after Aspergillus fumigatus that can be found in cystic fibrosis (CF). Mixed colonisation by S. apiospermum complex and A. fumigatus is also quite common. In this study we summarise all CF patients who were colonised by S. apiospermum complex during their childhood and we present two CF patients who were treated as fungal bronchitis due to S. apiospermum complex. The medical records of 400 CF patients were reviewed in order to identify those with positive respiratory cultures for S...
May 15, 2017: Mycoses
https://www.readbyqxmd.com/read/28504456/performance-of-mycology-and-histopathology-tests-for-the-diagnosis-of-toenail-onychomycosis-due-to-filamentous-fungi-dermatophyte-and-non-dermatophyte-moulds
#3
Fernanda G Lavorato, Dávson A Guimarães, Mario G Premazzi, Juan M Piñeiro-Maceira, Andréa R Bernardes-Engemann, Rosane Orofino-Costa
Improvement of laboratory diagnosis of onychomychosis is important so that adequate treatment can be safely implemented. To evaluate and compare the performance of mycological and histopathological examinations in onychomycoses caused by dermatophyte and non-dermatophyte moulds. Patients with lateral/distal subungual onychomycosis in at least one hallux were enrolled in the protocol and assessed via mycological and histopathological tests. The isolation of filamentous fungi was considered the gold standard...
May 15, 2017: Mycoses
https://www.readbyqxmd.com/read/28504318/antifungal-prophylaxis-in-newly-diagnosed-aml-patients-adherence-to-guidelines-and-feasibility-in-a-real-life-setting
#4
Sophie Berking, Daphne Doedens, Heidi Horns, Michael Fiegl, Helmut Ostermann, Christina T Rieger
Antifungal posaconazole prophylaxis for AML patients receiving induction chemotherapy has been routine at our centre since 2009. This retrospective study examined the feasibility and practicability of our prophylaxis guidelines in clinical practice. Data sets of 90 patients undergoing induction-chemotherapy for AML between 2011 and 2014 were evaluated regarding adherence to local guidelines for the administration of antifungal prophylaxis with posaconazole. 75.5% of the 90 patients received posaconazole prophylaxis...
May 15, 2017: Mycoses
https://www.readbyqxmd.com/read/28497621/endomyocardial-and-pericardial-aspergillosis-in-critically-ill-patients
#5
George Dimopoulos, Frantzeska Frantzeskaki, Marinos Kosmopoulos, Fabio Sylvio Taccone, Anne-Marie Van den Abeele, Pierre Bulpa, Frederic Forêt, Dirk Vogelaers, Stijn Blot
Invasive aspergillosis(IA) is a potentially lethal complication of Aspergillus infection affecting mainly immunocompromised hosts; however, during the last two decades its incidence was increasingly observed in critically ill immunocompetent patients. The objective of this study is to describe the clinical characteristics of histologically proven endomyocardial and pericardial invasion, in the context of IA, in critically ill patients. Eight critically ill patients with histopathological confirmation of endomyocardial/pericardial aspergillosis were evaluated...
May 12, 2017: Mycoses
https://www.readbyqxmd.com/read/28497502/improving-outcome-of-fungal-diseases-guiding-experts-and-patients-towards-excellence
#6
Oliver A Cornely, Cornelia Lass-Flörl, Katrien Lagrou, Valentina Arsic-Arsenijevic, Martin Hoenigl
Invasive fungal infections are on the rise and during recent years understanding the epidemiology of fungal infections improved. Over 1 billion people are affected and 25 million patients are at imminent risk of severe organ damage or death due to fungal infection. The European Confederation of Medical Mycology (ECMM), founded in 1993, is the roof organisation of 23 National Medical Mycology Societies in Europe. ECMM fights fungal infections at various levels, by creating and distributing scientific knowledge and promoting scientific exchange...
May 12, 2017: Mycoses
https://www.readbyqxmd.com/read/28480990/production-of-trichophyton-rubrum-microspores-in-large-quantities-and-its-application-to-evaluate-amorolfine-azole-compound-interactions-in-vitro
#7
Alexis Laurent, Michel Monod
Trichophyton rubrum is the most frequently isolated dermatophyte species in European countries. The lack or poor sporulation of T. rubrum has always been a major complication and a limiting factor when performing antifungal susceptibility testing. Therefore, we describe an in vitro method aiming to enhance sporulation of various T. rubrum isolates in order to perform antifungigrams. A combination of high CO2 tensions and incubation on PDA growth medium revealed to be optimal for sporulation of all tested T...
May 8, 2017: Mycoses
https://www.readbyqxmd.com/read/28444889/invasive-fungal-infections-in-paediatric-patients-treated-with-macromolecular-immunomodulators-other-than-tumour-necrosis-alpha-inhibitors
#8
REVIEW
Ioannis Kyriakidis, Athanasios Tragiannidis, Ilse Zündorf, Andreas H Groll
An expanding list of immunomodulatory or immunosuppressive monoclonal antibodies (mAbs) and biologic therapeutics is currently entering clinical practice, particularly in the areas of oncology, transplantation and autoimmune disorders. These agents are directed against molecules or cells involved in inflammation and immunity and may therefore be associated with serious and opportunistic infections. The purpose of this review was to critically analyse the literature on invasive fungal infections (IFIs) occurring in association with mAbs and fusion proteins other than tumour necrosis alpha (TNF-α) inhibitors, including therapeutics modulating T-cell-mediated pathologies (muromonab, abatacept, belatacept, ipilimumab, basiliximab, daclizumab), inducing lymphopenia (alemtuzumab), depleting CD20+ B cells (rituximab) and interfering with various targets (anakinra, natalizumab, blodalumab, ixekizumab and others) with a focus on children, and to provide a framework of evaluating the risk for IFIs in this population...
April 26, 2017: Mycoses
https://www.readbyqxmd.com/read/28436564/high-prevalence-of-superficial-white-onychomycosis-by-trichophyton-interdigitale-in-a-japanese-nursing-home-with-a%C3%A2-geriatric-hospital
#9
Seiji Watanabe, Kazushi Anzawa, Takashi Mochizuki
A mycological survey on feet was performed in a nursing home with a geriatric hospital to ascertain the prevalence of tinea lesions. Of 100 subjects, comprising 62 in the nursing home and 38 in the geriatric wing, 70 were diagnosed with tinea pedis, tinea unguium (onychomycosis) or both of which 54 had onychomycosis alone, nine tinea pedis alone and seven had co-existing onychomycosis and tinea pedis. The most common clinical type of onychomycosis was distal lateral subungual onychomycosis (DLSO) at 30 cases, followed by superficial white onychomycosis (SWO) at 23 cases...
April 24, 2017: Mycoses
https://www.readbyqxmd.com/read/28429890/prevalence-of-the-reversed-halo-sign-in-neutropenic-patients-compared-with-non-neutropenic-patients-data-from-a-single-centre-study-involving-27-patients-with-pulmonary-mucormycosis-2003-2016
#10
Jessie Bourcier, Pierre-Marie Heudes, Florent Morio, Thomas Gastinne, Patrice Chevallier, Fanny Rialland-Battisti, Claire Garandeau, Isabelle Danner-Boucher, Patrice Le Pape, Eric Frampas, Philippe Moreau, Claire Defrance, Pierre Peterlin
Pulmonary mucormycosis (PM) is a life-threatening infection and the diagnosis can be challenging. The objective was to retrospectively explore the value of the RHS in our cohort of 27 patients with mucormycosis and its relation to neutropenia. This was a retrospective study including all patients with a diagnosis of probable or proven invasive PM according to the 2008 EORTC/MSG criteria between September 2003 to April 2016. Fisher's exact test and Mann-Whitney test, with a P-value statistically significant under ...
April 21, 2017: Mycoses
https://www.readbyqxmd.com/read/28429862/epidemiology-of-invasive-fungal-diseases-in-children-with-solid-tumours-undergoing-autologous-haematopoietic-stem-cell-transplantation-a-10-year-experience-in-a-tertiary-italian-centre
#11
Paola Tatarelli, Maura Faraci, Ilaria Caviglia, Roberto Bandettini, Giuliana Cangemi, Gian Michele Magnano, Alberto Garaventa, Claudio Viscoli, Elio Castagnola
The objective of the study was to determine the incidence of invasive fungal disease (IFD) in children undergoing autologous haematopoietic stem cell transplantation (auHSCT) for solid tumours (ST). Retrospective study on auHSCT was performed in children with ST (January 2006-December 2015). Data on the number of patient-days at risk (pdr) during the first 30 and 90 days after auHSCT and cases of proven/probable IFDs were collected. Infection rate (IR, episodes/1000 pdr) and proportions and cumulative risk (CR) of IFD were evaluated...
April 21, 2017: Mycoses
https://www.readbyqxmd.com/read/28429840/non-response-to-fluconazole-maintenance-treatment-recidif-regimen-for-recurrent-vulvovaginal-candidosis-is-not-related-to-impaired-glucose-metabolism
#12
Svitrigaile Grinceviciene, Gert Bellen, Kateryna Ruban, Gilbert Donders
Is non-response to maintenance treatment for recurrent vulvovaginal candidosis (RCVV) related to the impaired glucose metabolism? In the ReCiDiF trial, women with RCVV were given a degressive regimen with fluconazole according to their clinical, microscopic and mycologic response. Data obtained from optimal, suboptimal and non-reponding patients were used for secondary analysis of medical history, physical status and family history for potential glucose impairment. Results were presented in means and percentages...
April 21, 2017: Mycoses
https://www.readbyqxmd.com/read/28425571/clinical-factors-affecting-costs-in-patients-receiving-systemic-antifungal-therapy-in-intensive-care-units-in-greece-results-from-the-estimator-study
#13
A Armaganidis, S Nanas, E Antoniadou, K Mandragos, K Liakou, A Koutsoukou, G Baltopoulos, G Nakos, A Kounougeri, K Ganas, A Prekates, M Kompoti, D Georgopoulos, I Pneumatikos, E Zakynthinos
Invasive fungal infections are common in intensive care units (ICUs) but there is a great variability in factors affecting costs of different antifungal treatment strategies in clinical practice. To determine factors affecting treatment cost in adult ICU patients with or without documented invasive fungal infection receiving systemic antifungal therapy (SAT) we have performed a prospective, multicentre, observational study enrolling patients receiving SAT in participating ICUs in Greece. During the study period, 155 patients received SAT at 14 participating ICUs: 37 (23...
April 20, 2017: Mycoses
https://www.readbyqxmd.com/read/28422366/oral-paracoccidioidomycosis-retrospective-analysis-of-55-brazilian-patients
#14
Aline Heloísa Trindade, Henrique Côrtes Meira, Igor Figueiredo Pereira, Julio César Tanos de Lacerda, Ricardo Alves de Mesquita, Vagner Rodrigues Santos
Paracoccidioidomycosis (PCM) is a rare fungal infection in the world, but endemic and acquired exclusively in Latin America, with the highest prevalence in South America and Brazil, particularly. Changes in oral cavity are common and constitute the first clinical manifestation in many patients. The aim of this study was to describe the prevalence of oral PCM and analyse the profile of the disease and patients. Retrospective research, consisting of information present in the medical records in the period 1998-2015, whose histopathological diagnosis was oral PCM...
April 19, 2017: Mycoses
https://www.readbyqxmd.com/read/28378904/otomastoiditis-caused-by-candida-auris-case-report-and-literature-review
#15
REVIEW
Hyoung Il Choi, Jin An, Jae Joon Hwang, Soo-Youn Moon, Jun Seong Son
Fungal otomastoiditis is a rare disease, but can be fatal for immunocompromised patients. Recently, there have been increasing cases of otologic infection caused by Candida auris. Candida auris can be easily misdiagnosed for other species and treatment is difficult due to multidrug resistance. Clinician should be aware of this rare pathogen, and it should be treated with appropriate antifungal agent with surgical debridement.
April 5, 2017: Mycoses
https://www.readbyqxmd.com/read/28370502/the-impact-of-real-life-treatment-strategies-for-candida-peritonitis-a-retrospective-analysis
#16
S Dubler, M Laun, C Koch, A Hecker, S Weiterer, B H Siegler, R Röhrig, M A Weigand, C Lichtenstern
Candida species are commonly detected isolates from abdominal foci. The question remains as to who would benefit from early empiric treatment in cases of Candida peritonitis. This study collected real-life data on critically ill patients with Candida peritonitis to estimate the relevance of the chosen treatment strategy on the outcome of these patients. One hundred and thirty-seven surgical intensive care unit (ICU) patients with intra-abdominal invasive Candidiasis were included in the study. Fifty-six patients did not get any antifungal agent...
April 3, 2017: Mycoses
https://www.readbyqxmd.com/read/28370366/new-insights-on-the-antibacterial-efficacy-of-miconazole-in-vitro
#17
P Nenoff, D Koch, C Krüger, C Drechsel, P Mayser
Miconazole is a broad-spectrum antifungal used in topical preparations. In the present investigation the minimal inhibitory concentration (MIC) of miconazole for eighty wild type strains of gram-positive and gram-negative bacteria isolated from infected skin lesions was assessed using a modified agar dilution test (adapted to CLSI, Clinical Laboratory Standards Institute). 14 ATCC reference strains served as controls. Miconazole was found efficacious against gram-positive aerobic bacteria (n=62 species), the MICs against Staphylococcus (S...
March 30, 2017: Mycoses
https://www.readbyqxmd.com/read/28338249/epidemiology-species-distribution-clinical-characteristics-and-mortality-of-candidaemia-in-a-tertiary-care-university-hospital-in-turkey-2007-2014
#18
Ayşegül Yeşilkaya, Özlem Azap, Mehtap Aydın, Mehtap Akçil Ok
Candidaemia still continues to be a serious medical concern and the epidemiology of candidaemia varies according to geographical areas. We aim to determine the incidence, local epidemiology, Candida species distribution and crude mortality rates of candidaemia. We retrospectively evaluated candidaemia episodes in between January 2007 and August 2014. We compared demographic, clinical, microbiological findings and mortality rates of episodes caused by Candida albicans and non-albicans Candida species. Overall the candidaemia incidences were 1...
March 24, 2017: Mycoses
https://www.readbyqxmd.com/read/28338245/infective-capacity-of-cryptococcus-neoformans-and-cryptococcus-gattii-in-a-human-astrocytoma-cell-line
#19
M C Olave, J C Vargas-Zambrano, A M Celis, E Castañeda, J M González
Pathogenesis of cryptococcosis in the central nervous system (CNS) is a topic of ongoing research, including the mechanisms by which this fungus invades and infects the brain. Astrocytes, the most common CNS cells, play a fundamental role in the local immune response. Astrocytes might participate in cryptococcosis either as a host or by responding to fungal antigens. To determine the infectivity of Cryptococcus neoformans var. grubii and Cryptococcus gattii in a human astrocytoma cell line and the induction of major histocompatibility complex (MHC) molecules...
March 24, 2017: Mycoses
https://www.readbyqxmd.com/read/28321926/evaluation-of-30-cases-of-mucormycosis-at-a-university-hospital-in-iran
#20
Reza Samarei, Naser Gharebaghi, Salar Zayer
Mucormycosis is a deadly invasive fungal infection and mainly affects immunocompromised patients. To investigate the clinical features of patients who developed mucormycosis and to determine the parameters, which influenced the outcome following mycotic infection. The current investigation retrospectively evaluated the demographic characteristics, clinical features, therapeutic data, as well as the outcomes of treatment in all cases of proven and probable mucormycosis diagnosed from 2002 until 2016 in our hospital...
March 20, 2017: Mycoses
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