Read by QxMD icon Read


Lígia de Souza Fernandes, Yuri Martins Amorim, Elton Libério da Silva, Samuel Calixto Silva, Alécia Junia Aparecida Santos, Franciele Natália Peixoto, Luara Moniele Neves Pires, Raquel Yumi Sakamoto, Flávia do Carmo Horta Pinto, Maria Virgínia Costa Scarpa, Marcelo Gonzaga de Freitas Araújo
Owing to the growing resistance among isolates of Candida species to usual antifungal agents and the well-known therapeutic potential of curcumin, the purpose of this study was to develop and validate a vaginal formulation containing this substance and to evaluating its effectiveness in the treatment of experimental vulvovaginal candidiasis METHODS: Curcumin was incorporated in a vaginal cream in three concentrations (0.01, 0.1 and 1.0%). The different concentrations of the cream and its controls were intravaginally administered in an immunosuppressed rat model to evaluate the efficacy in the treatment of experimental vulvovaginal candidiasis...
March 8, 2018: Mycoses
Raimunda Sâmia Nogueira Brilhante, Edmilson Emanuel Monteiro Correia, Glaucia Morgana de Melo Guedes, Jonathas Sales de Oliveira, Débora de Souza Collares Maia Castelo-Branco, Rossana de Aguiar Cordeiro, Adriana de Queiroz Pinheiro, Lúcio Jackson Queiroz Chaves, Waldemiro de Aquino Pereira Neto, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha
BACKGROUND: As shown by recent researches, most of the clinically relevant fungi, including dermatophytes, form biofilms in vitro and in vivo, which may present antimicrobial tolerance favoring recurrent infections. OBJECTIVES: The aim of this study was to determine the minimum inhibitory concentrations (MICs) of itraconazole (ITC), voriconazole (VCZ) and griseofulvin (GRI) against Trichophyton rubrum, Trichophyton tonsurans, Trichophyton mentagrophytes, Microsporum canis and Microsporum gypseum, in planktonic and biofilm growth...
March 8, 2018: Mycoses
Susana Córdoba, Guillermina Isla, Wanda Szusz, Walter Vivot, Alejandra Hevia, Graciela Davel, Cristina E Canteros
We studied 23 clinical and environmental strains of Sporothrix schenckii sensu lato collected from 1984 to 2017 in Argentina. The molecular identification (partial sequencing of a fragment of the calmodulin gene) of the strains was performed. For the yeast and mycelial phases, the in vitro susceptibility testing by a microdilution reference method was determined against eight antifungal drugs. Strains studied were identified as S. schenckii sensu stricto 13 (56.5%), S. brasiliensis 8 (34.7%) and S. globosa 2 (8...
March 3, 2018: Mycoses
Sandeep Kotwal, Geeta Sumbali, Supriya Sharma, Sanjana Kaul
Dermatophytes are considered as the main pathogens responsible for onychomycosis, but recently successive isolations of yeast-like fungi from the infected nails has led to consider these also as primary agents of nail infections. Trichosporon species which are non-candidal, basidiomycetous, yeast-like, anamorphic fungi are commonly isolated from soil but they are also emerging as important etiological agents of onychomycosis. Three species of Trichosporon viz., T. asahii, T. asteroides and T. faecale were isolated from the infected nails of three female members of a family from district Doda of Jammu and Kashmir State...
March 3, 2018: Mycoses
Franqueline Reichert Lima, Luzia Lyra, Lais Pontes, Maria Luiza Moretti, Cau D Pham, Shawn R Lockhart, Angélica Zaninelli Schreiber
Aspergillus spp. are the most common invasive mold infection and are responsible for high mortality. A. fumigatus is currently of interest because resistance to azole antifungals has emerged. The Campinas University Hospital (HC-UNICAMP) receives high-risk patients susceptible to opportunistic infections but there have been no reports of resistant A. fumigatus. This study aimed to assess the susceptibility profile of Aspergillus isolates, specifically looking for azole resistance. ITS and β-tubulin DNA sequencing was performed on 228 sequential clinical isolates...
February 22, 2018: Mycoses
Qi Ni, Chen Wang, Yuan Tian, Danfeng Dong, Cen Jiang, Enqiang Mao, Yibing Peng
BACKGROUND: Recently, Candida glabrata has emerged as a health-threatening pathogen and the rising resistance to antifungal agent in C. glabrata often leads to clinical treatment failure. OBJECTIVE: To investigate the evolution of drug resistance and adherence ability in four paired clinical isolates collected before and after antifungal treatment. METHODS: Sequence analysis, gene disruption, drug-susceptibility, adhesion tests, and real-time quantitative PCR were performed...
February 21, 2018: Mycoses
Juergen Prattes, Martin Hoenigl, Stefanie E-M Zinke, Sven Heldt, Susanne Eigl, Gemma L Johnson, Stephen Bustin, Evelyn Stelzl, Harald H Kessler
The newly developed AspID PCR assay for detection of Aspergillus spp. was evaluated with an interlaboratory quality control program panel and human bronchoalveolar lavage fluid (BALF) samples. With the quality control program, eight out of nine panel members were correctly identified. With the clinical study, 36 BALF samples that had been obtained from 18 patients with invasive pulmonary aspergillosis (IPA) and 18 without IPA were investigated. Sensitivity, specificity, positive and negative likelihood ratio for the AspID assay were 94...
February 20, 2018: Mycoses
Jochen Brasch, Vera Beck-Jendroschek, Viktoria Mahn
BACKGROUND: Recently we had shown that conidia-derived growth of many dermatophytes can be inhibited by curcumin plus exposure to visible light. OBJECTIVES: This method of photo inactivation should be developed further aiming for an option to stop mycelial growth in superficial tinea. METHODS: Wells of microtiter plates were inoculated with either mycelial or conidial elements collected from 5 strains of T. rubrum. Then either micellar curcumin or curcumin dissolved with DMSO was added and after 20 min the wells were filled up with Sabouraud broth...
February 20, 2018: Mycoses
Hamed Fakhim, Afsane Vaezi, Eric Dannaoui, Anuradha Chowdhary, Davood Nasiry, Leila Faeli, Jacques F Meis, Hamid Badali
The incidence of invasive fungal infections (IFIs) caused by uncommon Candida species with diverse virulence and susceptibility profiles has increased in recent years. Due to scarce clinical and experimental data on the pathogenicity of Candida auris, the aim of this study was to evaluate and compare the virulence of two rare clinically relevant species, C. auris and Candida haemulonii with Candida glabrata and Candida albicans in an immunocompetent murine model of disseminated infection. Immunocompetent ICR female mice were infected with three inoculum sizes (1×105 , 1×106 and 1×107 CFU/mouse) of two C...
February 19, 2018: Mycoses
George A Stamatiades, Petros Ioannou, George Petrikkos, Constantinos Tsioutis
BACKGROUND: Despite reports of fungal infections in patients with inflammatory bowel disease (IBD), their clinical and microbiological characteristics remain unknown. OBJECTIVES: The aim of this systematic review is to examine all available evidence regarding fungal infections in patients with IBD. METHODS: Systematic search of PubMed (through 27 May 2017) for studies providing data on clinical, microbiological, treatment and outcome data of fungal infections in patients with IBD...
February 17, 2018: Mycoses
Jade Couchepin, Anne-Sophie Brunel, Katia Jaton, Pascal Meylan, Pierre-Yves Bochud, Frédéric Lamoth
Invasive aspergillosis (IA) is a life-threatening infection affecting hematologic cancer patients with chemotherapy-induced neutropenia. The diagnosis of IA often relies on the detection of galactomannan (GM) in serum or bronchoalveolar lavage fluid (BAL). Bi-weekly serum GM screening has been proposed for a preemptive therapeutic approach of IA in patients not receiving mold-active prophylaxis. We have analyzed all IA cases among patients with hematologic malignancies and prolonged chemotherapy-induced neutropenia (>14 days) in our institution over a 10-year period (2007-2017)...
February 17, 2018: Mycoses
Khaled Alobaid, Mostafa Faty, Ahmed El-Nahas, Abdullatif Al-Terki, Zia Khan
Candida fungus ball is a rare presentation of urinary tract infections among adult patients and is associated with considerable morbidity. Because clinical signs are not specific, diagnosis is often delayed. Furthermore, treatment is occasionally difficult, and the approach to such cases varies widely among different centers. In this report, we describe a patient with retroperitoneal fibrosis who developed a renal fungus ball. Management of this challenging case is discussed, and review of the literature is presented...
February 12, 2018: Mycoses
Lucia Rangel-Gamboa, Fernando Martinez-Hernandez, Pablo Maravilla, Ana Flisser
BACKGROUND: Sporotrichosis is a subcutaneous mycosis that is caused by diverse species of Sporothrix. High levels of genetic diversity in Sporothrix isolates have been reported, but few population genetics analyses have been documented. AIM: To analyze the genetic variability and population genetics relations of Sporothrix schenckii Mexican clinical isolates and to compare them with other reported isolates. METHODS: We studied the partial sequences of calmodulin and calcium/calmodulin-dependent kinase genes in 24 isolates; 22 from Mexico, one fromColombia, and one ATCC® 6331™ ; the latter was used as a positive control...
February 2, 2018: Mycoses
Wesley J Hoffmann, Ian McHardy, George R Thompson
We describe a case of apparent mineralocorticoid excess (hypertension, hypokalemia, metabolic alkalosis, and low plasma renin activity) secondary to itraconazole therapy. Inhibition of 11β-hydroxysteroid dehydrogenase 2 was demonstrated, and withholding itraconazole led to resolution of adverse effects that did not recur with voriconazole. This report adds to a growing body of evidence linking apparent mineralocorticoid excess with certain triazoles. This article is protected by copyright. All rights reserved...
January 31, 2018: Mycoses
Guanzhao Liang, Yongnian Shen, Guixia Lv, Hailin Zheng, Huan Mei, Xiaoli Zheng, Xue Kong, Oliver Blechert, Dongmei Li, Weida Liu
We report a case of imported pulmonary coccidioidomycosis caused by Coccidioides posadasii in a patient who was misdiagnosed as tuberculosis and mistreated with antituberculosis medications for 18 months. The symptoms were not relieved until antifungal treatment was started. An extensive review of the coccidioidomycosis cases occurring in China reveals 38 cases, 16 of which had no associated history of travel to any traditional endemic areas. We speculate that some factors may drive Coccidioides spp. transference to China, which then causes those domestic infections...
January 31, 2018: Mycoses
Felix Bongomin, Rita O Oladele, Sara Gago, Caroline B Moore, Malcolm D Richardson
Fluconazole is the most commonly used antifungal agent for both the treatment of cryptococcal meningitis, and for prophylaxis against the disease. However, its prolonged use has the potential to exert selection pressure in favour of fluconazole-resistant strains. We evaluated the prevalence of fluconazole resistance of Cryptococcus spp. clinical isolates in 29 studies from 1988 to May 2017 included in EMBASE and MEDLINE databases. A total of 4,995 Cryptococcus isolates from 3,210 patients constituted this study; 248 (5...
January 29, 2018: Mycoses
Pranatharthi Chandrasekar, Bhawna Sirohi, Nita L Seibel, Jack W Hsu, Nkechi Azie, Chunzhang Wu, Markus Ruhnke
Neutropenia is linked to the development of invasive candidiasis/candidaemia, for which micafungin has demonstrated efficacy, but evidence in patients with neutropenia is limited. The aim of this study was to evaluate the efficacy of micafungin for the treatment of invasive candidiasis/candidaemia in patients with neutropenia (<500 neutrophils/μL) and without neutropenia. This pooled, post hoc analysis of 2 Phase 3 trials compared micafungin 100 mg/d (adults) and 2 mg/kg/d (paediatrics) with L-AmB 3 mg/kg/d (NCT00106288) and micafungin 100 mg/d and 150 mg/d with caspofungin 70 mg/d followed by 50 mg/d (adults) (NCT00105144); treatment duration 2-4 weeks (≤8 weeks for chronic disseminated candidiasis)...
January 24, 2018: Mycoses
Sibylle C Mellinghoff, Martin Hoenigl, Philipp Koehler, Anil Kumar, Katrien Lagrou, Cornelia Lass-Flörl, Jacques F Meis, Vidya Menon, Riina Rautemaa-Richardson, Oliver A Cornely
Candida species frequently cause blood stream infections and are reported to be the third to tenth most commonly isolated pathogens. Guidelines and standardised treatment algorithms provided by professional organisations aim to facilitate decision-making regarding diagnosis, management and treatment of candidaemia. In routine clinical practise, however, it may be challenging to comply with these guidelines. The reasons include lack of familiarity or feasibility to adherence, but also their length and complexity...
January 11, 2018: Mycoses
Ritesh Agarwal, Inderpaul S Sehgal, Sahajal Dhooria, Ashutosh N Aggarwal, Naresh Sachdeva, Sanjay K Bhadada, Mandeep Garg, Digambar Behera, Arunaloke Chakrabarti
Vitamin D deficiency is believed to a pathogenetic factor in patients with allergic bronchopulmonary aspergillosis (ABPA) and cystic fibrosis. Whether vitamin D deficiency is also prevalent in ABPA complicating asthma, remains unknown. Herein, we evaluate vitamin D levels in asthmatic patients with and without ABPA. In a prospective study, plasma vitamin D (25[OH]D) levels were measured in consecutive subjects with asthma (n=75), ABPA (n=158) and healthy volunteers (n=50). Vitamin D levels <20 ng/mL were considered as vitamin D deficiency...
January 4, 2018: Mycoses
Azza G A Farag, Mostafa A Hammam, Reda A Ibrahim, Reda Z Mahfouz, Nada F Elnaidany, Masroor Qutubuddin, Rehab R E Tolba
BACKGROUND: Most superficial mycotic infections of human skin are due to dermatophytes. Children are frequently affected due to different predisposing factors, particularly overcrowding in classrooms. OBJECTIVES: To estimate the prevalence of dermatophytes infections and their related risk factors among school children in Menoufia Governorate, Egypt. SUBJECTS AND METHODS: Six public primary and preparatory schools were randomly selected and their pupils (n= 3464) were asked to complete a predesigned questionnaire covering both personal data and suspected risk factors for superficial dermatophyte infections...
January 4, 2018: Mycoses
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"