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Mycoses

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https://www.readbyqxmd.com/read/30427072/evaluation-of-drug-susceptibility-test-for-efinaconazole-compared-with-conventional-antifungal-agents
#1
Min Seok Hur, Minji Park, Won Hee Jung, Yang Won Lee
BACKGROUND: Superficial fungal infections are one of the most common and burdensome skin problems affecting quality of life in patients. Various conventional antifungal agents have been used to treat fungal infections; however, various problems have been reported including drug interaction, drug resistance and low effectiveness. Efinaconazole is a novel antifungal agent, which has proven to be particularly effective against onychomycosis compared with conventional antifungal agents. However, the antifungal efficacy of Efinaconazole for specific strains has not been analysed...
November 14, 2018: Mycoses
https://www.readbyqxmd.com/read/30426598/developing-definitions-for-invasive-fungal-diseases-in-critically-ill-adult-patients-in-intensive-care-units-protocol-of-the-fungal-infections-definitions-in-icu-patients-fundicu-project
#2
M Bassetti, L Scudeller, D R Giacobbe, F Lamoth, E Righi, V Zuccaro, C Grecchi, C Rebuffi, M Akova, A Alastruey-Izquierdo, S Arıkan Akdagli, E Azoulay, S Blot, O Cornely, C Lass-Flörl, P Koehler, M Cuenca-Estrella, D W de Lange, F G De Rosa, J J De Waele, G Dimopoulos, J Garnacho-Montero, M Hoenigl, S S Kanj, J Maertens, I Martin-Loeches, P Muñoz, B J Kullberg, C Agvald-Ohman, G Poulakou, J Rello, M Sanguinetti, F S Taccone, J-F Timsit, A Torres, J A Vazquez, T Calandra
BACKGROUND: The reliability of diagnostic criteria for invasive fungal diseases (IFD) developed for severely immunocompromised patients is questionable in critically-ill adult patients in intensive care units (ICU). OBJECTIVES: To develop a standard set of definitions for IFD in critically-ill adult patients in ICU. METHODS: Based on a systematic literature review, a list of potential definitions to be applied to ICU patients will be developed by the ESCMID Study Group for Infections in Critically Ill Patients (ESGCIP) and the ESCMID Fungal Infection Study Group (EFISG) chairpersons...
November 13, 2018: Mycoses
https://www.readbyqxmd.com/read/30411397/first-time-isolation-and-quantification-of-basidiobolus-spp-from-reptile-faeces-in-kwazulu-natal-south-africa-using-selective-media
#3
Maike Claussen, Stefan Schmidt
Members of the genus Basidiobolus are potentially pathogenic fungi, known to cause mycoses in tropical and subtropical countries. Basidiobolus spp. can be associated with animals, and reptiles and amphibians are candidate vectors for the distribution of this fungus. The presence of Basidiobolus spp. was described for different reptiles in several African countries, although not for South Africa. In addition, quantitative data are scarce. The aim of this study was to analyse faeces of selected South African reptiles for the presence and quantity of "viable Basidiobolus units"...
November 8, 2018: Mycoses
https://www.readbyqxmd.com/read/30387195/false-positive-bronchoalveolar-lavage-galactomannan-effect-of-host-and-cut-off-value
#4
Dimitrios Farmakiotis, Audrey Le, Zoe Weiss, Nour Ismail, David W Kubiak, Sophia Koo
Invasive aspergillosis (IA) is the most common invasive mold infection (IMI) in patients with hematologic malignancies (HM), solid organ transplantation (SOT) or hematopoietic stem-cell transplantation (HSCT), patients receiving high-dose corticosteroids, and those in intensive care units (ICU). IA is associated with significant morbidity and mortality and may present insidiously. Definitive diagnosis ("proven" IMI) requires invasive procedures, which are often neither practical nor expedient for critically ill, immunocompromised patients...
November 1, 2018: Mycoses
https://www.readbyqxmd.com/read/30367553/perspectives-on-misidentification-of-trichophyton-interdigitale-trichophyton-mentagrophytes-using-internal-transcribed-spacer-region-sequencing-urgent-need-to-update-the-sequence-database
#5
REVIEW
Anuradha Chowdhary, Ashutosh Singh, Pradeep Kumar Singh, Ananta Khurana, Jacques F Meis
The taxonomy of the dermatophytes has been revisited using a novel multilocus phylogenetic approach and several neotypes and reference strains have been assigned for Trichophyton species. A single gene i.e. ITS region sequencing for identification of highly related species T. mentagrophytes/T. interdigitale warrant reassessment. As also the sequence database (Westerdijk and NCBI) that needs to be updated as several incorrect/obsolete entries of reference and neotype strains of T. interdigitale/T. mentagrophytes hampers correct identification of this complex...
October 26, 2018: Mycoses
https://www.readbyqxmd.com/read/30367528/dc-sign-and-vdr-polymorphisms-are-associated-with-chronic-form-of-paracoccidioidomycosis-with-oral-manifestations
#6
Tertuliano Alves Pereira Neto, Alessandro Antônio Costa Pereira, João Adolfo Costa Hanemann, Luiz Felipe Leomil Coelho, Luiz Cosme Cotta Malaquias
Paracoccidioidomycosis (PCM) is a granulomatous disease caused by fungi of the species complex of the Paracoccidioides genus. One of the main clinical manifestations of PCM is the presence oral lesions with the presence of epithelioid granulomas. In this work, we aimed to evaluate the frequency of SNPs in the TNF-α, JAK1, VDR, DC-SIGN and FcγRIIa genes in patients with chronic PCM and verify possible association of these SNPs with the organization pattern of the granulomas in the oral lesions. A total of 66 samples of DNA were obtained from oral lesions biopsies and 106 DNA samples were obtained from healthy individuals...
October 26, 2018: Mycoses
https://www.readbyqxmd.com/read/30350895/exserohilum-infections-in-australian-queensland-children
#7
Hazel C Dobinson, Gregory Down, Julia E Clark
BACKGROUND: Exserohilum species are environmental molds that can cause skin infection and sinusitis in both normal and immunosuppressed children. This study reviews pediatric cases of Exserohilum infection in Queensland, Australia, to identify the spectrum of disease and its clinical course. METHODS: All culture positive samples of Exserohilum species in children <18 years of age were identified from the Queensland Health Laboratory database (April 2003 - April 2018)...
October 23, 2018: Mycoses
https://www.readbyqxmd.com/read/30341799/genotypic-diversity-and-antifungal-susceptibility-of-cryptococcus-neoformans-isolates-from-pediatric-patients-in-china
#8
Nan Hong, Min Chen, Nan Xu, Abdullah M S Al-Hatmi, Chao Zhang, Wei H Pan, Ferry Hagen, Teun Boekhout, Jianping Xu, Xian B Zou, Wan Q Liao
Cryptococcosis is a life-threatening mycosis primarily occurring in adult patients particularly those with immunosuppression such as HIV infection/AIDS. The number of reported cases of pediatric cryptococcosis has increased in the last decade around the world, including China. However, current information on the characteristics of cryptococcosis in children, particularly the genotypic diversity and antifungal susceptibility of the isolates, is limited. In the present study, a total of 25 pediatric isolates of Cryptococcus neoformans were genotyped using the ISHAM-MLST scheme...
October 19, 2018: Mycoses
https://www.readbyqxmd.com/read/30338581/invasive-mucormycosis-in-children-with-cance-r-a-retrospective-study-from-the-infection-working-group-of-italian-pediatric-hematology-oncology-association
#9
P Muggeo, E Calore, N Decembrino, S Frenos, F De Leonardis, A Colombini, F Petruzziello, K Perruccio, M Berger, R Burnelli, G A Zanazzo, N Santoro, S Cesaro
BACKGROUND: Invasive mucormycosis is a rare but frequently fatal fungal disease. The acute and rapidly progressive evolution causes unfavourable outcome in 22-59% of patients and its treatment represents a clinical challenge, especially in immunocompromised patients. Current data in pediatric oncological patients are limited. OBJECTIVES: The infection Working Group of the Italian Association of Pediatric Hematology and Oncology (AIEOP) analyzed the episodes of invasive mucormycosis occurred between 2009 and 2016...
October 18, 2018: Mycoses
https://www.readbyqxmd.com/read/30338567/a-human-subcutaneous-infection-by-microascus-ennothomasiorum-sp-nov
#10
Jochen Brasch, Vera Beck-Jendroschek, Isabel Iturrieta-González, Karin Voss, Josepa Gené
A 60-year-old woman presented with a nodular granulomatous skin lesion on her right thumb. It had developed after inoculation of a splinter of wood. Because it was resistant to various therapies, the nodule was finally excised. Complete healing followed this surgery and a melanized filamentous fungus with scopulariopsis-like morphology was recovered from the dermal tissue. Fitting with no known species, the fungus was subjected to extensive morphological, physiological and genetic investigations. It was characterised by resistance to cycloheximide, growth at 37 °C, branched conidiophores with cylindrical annellides in brush-like groups producing dark conidia in basipetal chains, and cleistothecia with ellipsoidal to slightly reniform ascospores...
October 18, 2018: Mycoses
https://www.readbyqxmd.com/read/30329192/diagnostic-workout-to-assess-early-response-indicators-in-invasive-pulmonary-aspergillosis-in-adult-patients-with-hematologic-malignancies
#11
REVIEW
Werner J Heinz, Jörg J Vehreschild, Dieter Buchheidt
In immunocompromised patients with acute leukaemia as well as in allogeneic hematopoietic stem cell transplant patients, pulmonary lesions are commonly seen. Existing guidelines provide useful algorithms for diagnostic procedures and treatment options, but they do not give recommendations on how to evaluate early success or failure and if or when it is best to change therapy. Here we review the diagnostic techniques currently used in association with clinical findings and propose an approach using a combination of computer tomography, clinical and all available biomarkers and inflammation parameters, especially those positive at baseline, to assess early response in invasive pulmonary aspergillosis...
October 17, 2018: Mycoses
https://www.readbyqxmd.com/read/30307067/prevalence-of-low-inflammatory-tinea-genitalis-in-southern-china
#12
Songchao Yin, Xiaoyuan Xie, Meirong Li, Xin Zhou, Ling Wei, Zhirui Chen, Jian Chen, Chun Lu, Sybren de Hoog, Wei Lai, Peiying Feng
BACKGROUND: Emergence of highly inflammatory genital dermatophyte infections has been reported from Southeast Asia. In view of this, knowledge of the non-outbreak fungal flora of the genitals is required as a baseline study. OBJECTIVES: We present our 12-year experience in a tertiary clinic with the diagnosis of scrotal fungal infections. METHODS: A retrospective review was performed of patients with a diagnosis of scrotal fungal infections proven by direct microscopy and culture...
October 11, 2018: Mycoses
https://www.readbyqxmd.com/read/30267601/rhodotorula-species-infections-in-humans-a-systematic-review
#13
REVIEW
Petros Ioannou, Rodanthi Vamvoukaki, George Samonis
BACKGROUND: Fungal infections by Rhodotorula species are increasingly reported in the literature and consist of bloodstream infections, especially in patients with central venous catheters (CVC), as well as central nervous system (CNS), ocular and other less frequent infections. OBJECTIVES: The aim of this systematic review was to record and evaluate all available evidence regarding infections by Rhodotorula species. METHODS: Systematic review of PubMed (through 9 August 2017) for studies providing epidemiological, clinical, microbiological, as well as treatment data and outcomes of Rhodotorula species infections...
September 29, 2018: Mycoses
https://www.readbyqxmd.com/read/30267594/micafungin-may-be-safely-administered-as-outpatient-parenteral-antimicrobial-therapy-for-chronic-pulmonary-aspergillosis
#14
Akaninyene A Otu, Felix Bongomin, Rohit Bazaz, Chris Harris, David W Denning, Chris Kosmidis
BACKGROUND: Intravenous micafungin has been reported as a treatment alternative in patients with chronic pulmonary aspergillosis (CPA) where long-term oral triazole therapy is unfeasible. OBJECTIVES: We evaluated the safety and efficacy of micafungin administered via the outpatient parenteral antimicrobial therapy (OPAT) service for the treatment of CPA. METHODS: We included all CPA patients who received micafungin via OPAT between April 2016 and March 2018...
September 29, 2018: Mycoses
https://www.readbyqxmd.com/read/30256460/epidemiology-of-aspergillus-species-causing-keratitis-in-mexico
#15
Abdullah M S Al-Hatmi, Marino Alcantara Castro, G Sybren de Hoog, Hamid Badali, Victor Flores Alvarado, Paul E Verweij, Jacques F Meis, Virginia Vanzzini Zago
BACKGROUND: The incidence of fungal keratitis has increased in recent years. While the epidemiology and clinical roles of various Candida and Fusarium species has been relatively well-identified in infections of the eye, data regarding keratitis caused by Aspergillus species are scant. Accurate and rapid diagnosis is important for successful management of this infection. OBJECTIVES: To present the first molecular epidemiological data from Mexico during a four-year period of cases admitted with Aspergillus keratitis to a tertiary care eye institution in Mexico City...
September 26, 2018: Mycoses
https://www.readbyqxmd.com/read/30255665/molecular-identification-and-antifungal-susceptibility-of-clinical-fungal-isolates-from-onychomycosis-uncommon-and-emerging-species
#16
Iman Haghani, Masoomeh Shams-Ghahfarokhi, Abdolhossein Dalimi Asl, Tahereh Shokohi, Mohammad Taghi Hedayati
Onychomycosis is a common nail problem, accounting for up to 50% of all nail diseases. The aim of the present study was to determine the species distribution based on the restriction fragment length polymorphism and susceptibility patterns of the causative agents of onychomycosis. This cross-sectional study was conducted on nail samples collected from 257 patients suspected of onychomycosis during 14 months. Fungal isolates was identified by polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) with the enzymes Msp I, Mva I, Alw I and sequencing...
September 25, 2018: Mycoses
https://www.readbyqxmd.com/read/30230062/the-epidemiology-of-non-candida-yeast-isolated-from-blood-the-asia-surveillance-study
#17
Shang-Yi Lin, Po-Liang Lu, Ban Hock Tan, Arunaloke Chakrabarti, Un-In Wu, Jui-Hsuan Yang, Atul K Patel, Ruo Yu Li, Siriorn P Watcharananan, Zhengyin Liu, Ariya Chindamporn, Ai Ling Tan, Pei-Lun Sun, Li-Yin Hsu, Yee-Chun Chen
BACKGROUND: Current guidelines recommend echinocandins as first-line therapy for candidemia. However, several non-Candida yeast are non-susceptible to echinocandins (echinocandin non-susceptible yeast, ENSY), including Cryptococcus, Geotrichum, Malassezia, Pseudozyma, Rhodotorula, Saprochaete, Sporobolomyces and Trichosporon. In laboratories that are not equipped with rapid diagnostic tools, it often takes several days to identify yeast, and this may lead to inappropriate presumptive use of echinocandins in patients with ENSY fungemia...
September 19, 2018: Mycoses
https://www.readbyqxmd.com/read/30230044/cutaneous-infections-by-dematiaceous-opportunistic-fungi-diagnosis-and-management-in-11-solid-organ-transplant-recipients
#18
C Ferrándiz-Pulido, M T Martin-Gomez, T Repiso, C Juárez, B Ferrer, I López-Lerma, G Aparicio, C González-Cruz, F Moreso, A Román, V García-Patos
BACKGROUND: The incidence of cutaneous infections by dematiaceous fungi is rising in our environment due to the high number of solid organ transplant recipients (SOTR). OBJECTIVE: To review our experience in the management of cutaneous phaeohyphomycoses in a Spanish reference center for dermatological care of SOTR. METHODS: Retrospective clinical, histopathological and microbiological review of all SOTR diagnosed of a phaeohyphomycosis in a 7-year period...
September 19, 2018: Mycoses
https://www.readbyqxmd.com/read/30230043/tolerability-of-isavuconazole-after-posaconazole-toxicity-in-leukaemia-patients
#19
Adam J DiPippo, Caitlin R Rausch, Dimitrios P Kontoyiannis
BACKGROUND: Posaconazole (PCZ) is widely used for prophylaxis or treatment of invasive fungal infections (IFIs) in leukaemia patients. However, issues with PCZ tolerability can result in treatment interruption. Isavuconazole (ISA) has a similar broad spectrum of activity to PCZ; however, real-world data regarding the tolerability of ISA after PCZ toxicity are lacking. OBJECTIVES: To describe the tolerability of ISA after PCZ toxicity in leukaemia patients. PATIENTS/METHODS: We retrospectively assessed tolerability of ISA after PCZ toxicity in adult leukaemia patients (March 2015 to November 2017)...
September 19, 2018: Mycoses
https://www.readbyqxmd.com/read/30204268/arthroderma-chiloniense-sp-nov-isolated-from-human-stratum-corneum-description-of-a-new-arthroderma-species
#20
Jochen Brasch, Vera Beck-Jendroschek, Karin Voss, Andrey Yurkov, Yvonne Gräser
A 68-year-old woman was submitted to our hospital because of erythematous and scaly skin lesions. To exclude tinea samples of stratum corneum were collected and used for mycological investigations. In this material, no fungal elements were detected microscopically, but inoculation on Sabouraud agar with cycloheximide yielded a presumptive dermatophyte fungus. Subsequent detailed investigations with conventional morphological and physiological methods and a phylogenetic analysis of the combined LSU rRNA gene (D1/D2 domains) and ITS region sequences suggested that the fungus represents a hitherto undescribed species of the genus Arthroderma...
September 11, 2018: Mycoses
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