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Mycoses

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https://www.readbyqxmd.com/read/29325218/equal-candida-score-an-ecmm-score-derived-from-current-guidelines-to-measure-quality-of-clinical-candidemia-management
#1
Sibylle C Mellinghoff, Martin Hoenigl, Philipp Koehler, Anil Kumar, Katrien Lagrou, Cornelia Lass-Flörl, Jacques F Meis, Vidya Menon, Riina Rautemaa-Richardson, Oliver A Cornely
Candida species frequently cause blood stream infections and are reported to be the third to tenth most commonly isolated pathogens. Guidelines and standardized treatment algorithms provided by professional organisations aim to facilitate decision-making regarding diagnosis, management, and treatment of candidemia. In routine clinical practise, however, it may be challenging to comply with these guidelines. The reasons include lack of familiarity or feasibility to adherence, but also their length and complexity...
January 11, 2018: Mycoses
https://www.readbyqxmd.com/read/29314357/vitamin-d-levels-in-asthmatic-patients-with-and-without-allergic-bronchopulmonary-aspergillosis
#2
Ritesh Agarwal, Inderpaul S Sehgal, Sahajal Dhooria, Ashutosh N Aggarwal, Naresh Sachdeva, Sanjay K Bhadada, Mandeep Garg, Digambar Behera, Arunaloke Chakrabarti
Vitamin D deficiency is believed to a pathogenetic factor in patients with allergic bronchopulmonary aspergillosis (ABPA) and cystic fibrosis. Whether vitamin D deficiency is also prevalent in ABPA complicating asthma, remains unknown. Herein, we evaluate vitamin D levels in asthmatic patients with and without ABPA. In a prospective study, plasma vitamin D (25[OH]D) levels were measured in consecutive subjects with asthma (n=75), ABPA (n=158) and healthy volunteers (n=50). Vitamin D levels <20 ng/mL were considered as vitamin D deficiency...
January 4, 2018: Mycoses
https://www.readbyqxmd.com/read/29314351/epidemiology-of-dermatophyte-infections-among-school-children-in-menoufia-governorate-egypt
#3
Azza G A Farag, Mostafa A Hammam, Reda A Ibrahim, Reda Z Mahfouz, Nada F Elnaidany, Masroor Qutubuddin, Rehab R E Tolba
BACKGROUND: Most superficial mycotic infections of human skin are due to dermatophytes. Children are frequently affected due to different predisposing factors, particularly overcrowding in classrooms. OBJECTIVES: To estimate the prevalence of dermatophytes infections and their related risk factors among school children in Menoufia Governorate, Egypt. SUBJECTS AND METHODS: Six public primary and preparatory schools were randomly selected and their pupils (n= 3464) were asked to complete a predesigned questionnaire covering both personal data and suspected risk factors for superficial dermatophyte infections...
January 4, 2018: Mycoses
https://www.readbyqxmd.com/read/29285801/tinea-faciei-in-a-central-portuguese-hospital-a-9-year-survey
#4
Ana Borges, Ana Brasileiro, Célia Galhardas, Margarida Apetato
Tinea faciei is a relatively uncommon dermatophytosis that affects the glabrous skin of the face. The aim of this study was to analyse the epidemiologic, clinical and mycological features of tinea faciei cases diagnosed at the Dermatology and Venereology Department of Hospital Santo António dos Capuchos (Lisbon, Portugal). Consecutive cases diagnosed between 2008 and 2016 were studied retrospectively. A total of 72 tinea faciei cases have been diagnosed, involving 37 male and 35 female, aged between 8 months and 86 years...
December 28, 2017: Mycoses
https://www.readbyqxmd.com/read/29284182/cryptococcosis-and-cryptococcal-meningitis-new-predictors-and-clinical-outcomes-at-a-united-states-academic-medical-center
#5
Bahar H Kashef Hamadani, Carlos Franco-Paredes, Bruce McCollister, Leland Shapiro, David Beckham, Andrés F Henao-Martínez
Since the diagnosis of cryptococcosis is challenging in low prevalence settings, uncovering predictive factors can improve early diagnosis and timely treatment. The aim of the study was to relate clinical outcomes to predictive variables for the presence of cryptococcosis. A retrospective case-control study matching by collection date, age, and gender at a 1:2 ratio (55 cases and 112 controls) was performed in case patients diagnosed with Cryptococcus infection at the University of Colorado Hospital between 2000 and 2017 (n=167)...
December 28, 2017: Mycoses
https://www.readbyqxmd.com/read/29280202/environmental-distribution-of-cryptococcus-species-and-some-other-yeast-like-fungi-in-india
#6
Anupam Prakash, Harbans Singh Randhawa, Zia Uddin Khan, Suhail Ahmad, Ferry Hagen, Jacques F Meis, Anuradha Chowdhary
A study of environmental distribution revealed the occurrence of Cryptococcus neoformans and C. gattii in 9% and 3%, respectively, of 611 samples investigated. C. neoformans showed the highest isolation frequency from tree trunk hollows in Delhi (31%), whereas, C. gattii occurred in 12% of the samples in Delhi and 5% in Rajasthan. In addition, Cryptococcus laurentii (=Papiliotrema laurentii), C. rajasthanensis (=Papiliotrema rajasthanensis), C. podzolicus (=Saitozyma podzolica) and C. flavescens (=Papiliotrema flavescens), occurred in 0...
December 27, 2017: Mycoses
https://www.readbyqxmd.com/read/29280198/candiduria-in-kidney-transplant-recipients-is-antifungal-therapy-useful
#7
Blandine Denis, Dorothée Chopin, Prescillia Piron, Matthieu Resche-Rigon, Stéphane Bretagne, Maud Gits-Muselli, Marie-Noelle Peraldi, Imad Abboud, Jean-Michel Molina
A French single-center retrospective study between 2010-2014 was undertaken to assess candiduria's incidence in kidney transplant recipients (KTR), and the use and impact of antifungal treatment on outcome. Candiduria was defined as a urine culture with ≥ 103 cfu/mL of Candida species. Candiduria clearance, severe complications and death rates were estimated by Kaplan-Meier methods and the effect of treatment by Cox models. 52/1223 (4.3%) KTR had ≥ 1 episode of candiduria, 42 (81%) were female, 18 (35%) had diabetes, with an incidence of 2...
December 27, 2017: Mycoses
https://www.readbyqxmd.com/read/29280197/fulminant-cryptococcus-neoformans-infection-with-fatal-pericardial-tamponade-in-a-patient-with-chronic-myelomonocytic-leukemia-who-was-treated-with-ruxolitinib-case-report-and-review-of-fungal-pericarditis
#8
Jing Liu, Elie Mouhayar, Jeffrey J Tarrand, Dimitrios P Kontoyiannis
Cryptococcus neoformans is a saprophytic fungal pathogen that can cause serious illness in immune-compromised hosts and it presents with a wide variety of clinical symptoms. We present a fatal case of fulminant C. neoformans infection presenting as pericardial tamponade in a 71-year-old male with chronic myelomonocytic leukemia undergoing chemotherapy with the JAK-STAT inhibitor ruxolitinib. We also review the published cases of fungal pericarditis/tamponade. In addition to illustrating an atypical presentation of C...
December 27, 2017: Mycoses
https://www.readbyqxmd.com/read/29274093/interactions-between-candida-albicans-and-candida-glabrata-in-biofilms-influence-of-the-strain-type-culture-medium-and-glucose-supplementation
#9
Thayse Yumi Hosida, Thamires Priscila Cavazana, Mariana Henriques, Juliano Pelim Pessan, Alberto Carlos Botazzo Delbem, Douglas Roberto Monteiro
The relationship among Candida species may be influenced by several factors. Thus, this study evaluated the interactions between Candida albicans and Candida glabrata in biofilms, varying the strain type, culture medium and glucose supplementation. Biofilms were formed for 48 h in SDB or RPMI 1640, supplemented with 0, 1 or 5% glucose. Each strain of C. albicans was combined with two strains of C. glabrata, generating 4 biofilm associations, which were quantified by colony-forming units (CFUs), total biomass and metabolic activity...
December 23, 2017: Mycoses
https://www.readbyqxmd.com/read/29274090/case-of-femoral-pseudarthrosis-due-to-scedosporium-apiospermum-in-an-immunocompetent-patient-with-successful-conservative-treatment-and-review-of-literature
#10
Aurélien Dinh, Olivier Demay, Martin Rottman, Fabrice Gaudot, Marie-Elisabeth Bougnoux, Frédérique Bouchand, Hélène Coignard, Claire Rouzaud, Benjamin Davido, Clara Duran, Christophe Nich
Scedosporium apiospermum is a ubiquitous filamentous fungus, commonly found in soil, sewage, and polluted waters. It is rarely pathogenic but can cause a broad spectrum of clinical diseases, which can be localized or disseminate to distant organs. The disseminated form of the disease is mostly seen among immunocompromised patients. However, some rare cases of disseminated disease have been reported in immunocompetent individuals. Treatment of these infections is challenging because of their natural resistance to many antifungal agents...
December 23, 2017: Mycoses
https://www.readbyqxmd.com/read/29274088/autopsy-and-biopsy-study-of-paracoccidioidomycosis-and-neuroparacoccidioidomycosis-with-and-without-hiv-coinfection
#11
Sergio Monteiro de Almeida, Thiago Henrique Roza, Gabriel L O Salvador, Luís Felipe Izycki, Giuliana Locatelli, Isaias Dos Santos, Afonso Aragão, Luis Fernando Bleggi Torres, Lucia Helena de Noronha
BACKGROUND: Paracoccidioidomycosis (PCM) is a systemic mycosis prevalent among immunocompetent patients in Latin America. OBJECTIVE: This study aimed to describe the frequency, demographics, and clinical characteristics of central nervous system PCM (NPCM) and PCM in an endemic region, and the impact of human immunosuppression virus (HIV) co-infection. PATIENTS/METHODS: This was a retrospective study of autopsy and biopsy reports from the Medical Pathology Section of the Hospital de Clinicas, UFPR, Curitiba, Southern Brazil, between 1951 and 2014...
December 23, 2017: Mycoses
https://www.readbyqxmd.com/read/29272049/candida-glabrata-prosthetic-joint-infection-successfully-treated-with-anidulafungin-a-case-report-and-review-of-the-literature
#12
Christos Koutserimpas, George Samonis, Emmanouil Velivassakis, Stylliani Iliopoulou-Kosmadaki, Georgios Kontakis, Diamantis P Kofteridis
Non-albicans Candida prosthetic joint infection (PJI) is extremely rare. A case of a Candida glabrata knee PJI in a 68 years old splenectomized female smoker, suffering from chronic obstructive pulmonary disease (COPD) and alcoholism is reported. The patient presented with a peri-prosthetic fracture, 15 years after total knee replacement surgery. Cultures of the intraoperative peri-prosthetic tissue and materials yielded C. glabrata, as well as a methicillin resistant S. epidermitis. The patient was treated with with anidulafungin and vancomycin...
December 22, 2017: Mycoses
https://www.readbyqxmd.com/read/29205524/cerebral-phaeohyphomycosis-due-to-rhinocladiella-mackenziei-in-persian-gulf-region-a-case-and-review
#13
Rasoul Mohammadi, Abdolrasoul Mohammadi, Fereshteh Ashtari, Farzin Khorvash, Atousa Hakamifard, Afsane Vaezi, Javad Javidnia, Jacques F Meis, Hamid Badali
Cerebral phaeohyphomycosis is frequently a fatal disease caused by truly neurotropic dematiaceous fungi. Although rare, this infection occurs especially among immunocompetent patients, and the clinical symptoms are often misdiagnosed as a cerebral tumour or bacterial brain abscess. The appropriate diagnosis and therapy of cerebral infections by melanized fungi are very challenging if they are caused by mysterious fungi with unknown ecological niche. We reported the second case of cerebral phaeohyphomycosis due to Rhinocladiella mackenziei in Iran and the first culture-confirmed case...
December 5, 2017: Mycoses
https://www.readbyqxmd.com/read/29193377/evaluation-of-a-new-fluorescent-reagent-fluorescent-brightener-85-for-the-diagnosis-of-suspected-onychomycosis-compared-with-potassium-hydroxide
#14
Xueping Yue, Aiping Wang, Hongwei Wang, Qing Li, Xiuling Yue
BACKGROUND: Onychomycosis is a common fungal infection in dermatology clinics. The commonly used diagnostic method, potassium hydroxide (KOH) direct microscopy, does not have a high positive detection rate. Therefore, a new diagnostic method is needed to confirm onychomycosis. OBJECTIVES: The objective of this research was to use fluorescent brightener 85 (FB 85), a new fluorescent reagent for fungi detection, and to evaluate this new method based on the diagnostic positive rate, accuracy and efficiency in suspected onychomycosis compared with the KOH method...
November 29, 2017: Mycoses
https://www.readbyqxmd.com/read/29178398/successful-treatment-of-chromoblastomycosis-of-10-year-duration-due-to-fonsecaea-nubica
#15
Liya He, Jianchi Ma, Xin Mei, Sha Lu, Xiqing Li, Liyan Xi
We report a case of chromoblastomycosis due to presence of large plaque and verrucous hyperplasia lesions on the left upper limb, with elbow abnormal activities, in a 56-year-old male. The diagnosis of chromoblastomycosis was based on gross and microscopic morphologies, histopathological examination and clinical manifestation. Molecular tools were applied to identifying the causative agent: Fonsecaea nubica, which is rarely reported to be associated with chromoblastomycosis. The patient was initially treated orally with terbinafine (250 mg/day) and itraconazole (200 mg/day), subsequently patient received thermotherapy (45-50 °C, 3 hours/day) for one month...
November 25, 2017: Mycoses
https://www.readbyqxmd.com/read/29178247/isavuconazole-shortens-the-qtc-interval
#16
Sibylle C Mellinghoff, Matteo Bassetti, Daniela Dörfel, Stefan Hagel, Nicola Lehners, Andrzej Plis, Enrico Schalk, Antonio Vena, Oliver A Cornely
BACKGROUND: Isavuconazole is a novel antifungal drug, approved for treatment of adults with invasive aspergillosis and mucormycosis. While azoles as a class effect are known to prolong QTc interval, clinical trials have shown that isavuconazole administration may cause shortening in a dose-related manner. Here, we assessed the effects of isavuconazole on the length of QTc interval. OBJECTIVES: To describe changes of the QTc interval induced by isavuconazole treatment...
November 25, 2017: Mycoses
https://www.readbyqxmd.com/read/29125660/primary-prophylaxis-of-invasive-fungal-infections-with-posaconazole-or-itraconazole-in-patients-with-acute-myeloid-leukemia-or-high-risk-myelodysplastic-syndromes-undergoing-intensive-cytotoxic-chemotherapy-a-real-world-comparison
#17
Mar Tormo, Ariadna Pérez-Martínez, Marisa Calabuig, Juan Carlos Hernández-Boluda, Paula Amat, David Navarro, Carlos Solano
This is an observational-retrospective study comparing the real-world outcomes associated with posaconazole vs. itraconazole as prophylaxis treatments. Two hundred and ninety-three patient admissions attributable to 174 patients were included in the study. Patients were treated with itraconazole (n = 114 admissions; 39%) or posaconazole (n = 179; 61%). Antifungal prophylaxis failure (APF) due to treatment-related adverse events (in 34 out of 293 patient admissions; 11.6%) was more frequent in the posaconazole group (6...
November 10, 2017: Mycoses
https://www.readbyqxmd.com/read/29125646/epidural-abscess-caused-by-schizophyllum-commune-a-rare-case-of-rhinogenic-cranial-complication-by-a-filamentous-basidiomycete
#18
Kazuya Tone, Ryuichi Fujisaki, Shigehiro Hagiwara, Takashi Tamura, Shinobu Ishigaki, Mohamed Mahdi Alshahni, Makoto Takehisa, Takehiro Watanabe, Takuya Yasui, Takuo Tokairin, Toshiyo Sagawa, Tetsuya Sakamoto, Ken Ito, Kazuyoshi Kuwano, Koichi Makimura
Central nervous system (CNS) infections due to filamentous basidiomycetes are extremely rare. We encountered a case of epidural abscess due to Schizophyllum commune that extended from sinusitis. A 53-year-old Japanese man presented at our hospital with a headache. Computed tomography (CT) of the cranium and sinuses showed ethmoid and sphenoid sinusitis with no intracranial abnormalities. The patient was diagnosed with acute sinusitis and underwent antibiotic treatment. However, the symptoms deteriorated, and the patient came to our hospital again with consciousness disturbance...
November 10, 2017: Mycoses
https://www.readbyqxmd.com/read/29112326/real-world-challenges-and-unmet-needs-in-the-diagnosis-and-treatment-of-suspected-invasive-pulmonary-aspergillosis-in-patients-with-hematological-diseases-an-illustrative-case-study
#19
Martin Hoenigl, Juergen Prattes, Peter Neumeister, Albert Wölfler, Robert Krause
Recent years have seen important advances in the diagnosis of invasive pulmonary aspergillosis (IPA), complemented by the introduction of new therapies. Despite this, IPA remains a major cause of infection-related mortality in patients with hematological diseases. There are two main reasons for this. First, diagnosis of IPA remains a challenge, since risk factors and the clinical, radiological and mycological presentations vary not only by fungal disease stage, but also by patient group (e.g. neutropenic versus non-neutropenic patients)...
November 7, 2017: Mycoses
https://www.readbyqxmd.com/read/29110351/posaconazole-liquid-vs-tablet-formulation-in-lung-transplant-recipients
#20
D Telzer, A Weber, F Ihle, S Matthes, F Ceelen, G Zimmermann, N Kneidinger, R Schramm, H Winter, M Zoller, M Vogeser, J Behr, C Neurohr
BACKGROUND: Posaconazole is an extended-spectrum triazole antifungal used in the treatment and prophylaxis of Aspergillus infections. It is available as oral suspension (POS-Liq) and delayed-release tablets (POS-Tab). OBJECTIVES: The aim of this longitudinal, retrospective study was to compare the clinical effectiveness, toxicity, and pharmacokinetics of POS-Liq vs. POS-Tab in lung transplant recipients (LTx-recipients), who were treated with both formulations subsequently...
November 6, 2017: Mycoses
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