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Journal of Cardiology

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https://www.readbyqxmd.com/read/29439887/a-challenge-for-mutation-specific-risk-stratification-in-long-qt-syndrome-type-1
#1
Noriaki Yagi, Hideki Itoh, Takashi Hisamatsu, Yukinori Tomita, Hiromi Kimura, Yusuke Fujii, Takeru Makiyama, Minoru Horie, Seiko Ohno
BACKGROUND: The relationship between mutation locations in KCNQ1 which is a major gene in long QT syndrome (LQTS) and phenotype has been analyzed and used for risk stratification. Mutations in the transmembrane region (TM) or cytoplasmic-loop (C-loop) are associated with more frequent cardiac events than those in other regions. However, accumulation of LQTS type 1 (LQT1) patients poses the question of whether the location specific risk stratification is really effective. METHODS: The study cohort consisted of 67 KCNQ1 mutation carriers and 13 family members who were suspected as having LQTS due to sudden cardiac death or syncope from 36 unrelated families...
February 10, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29415819/a-new-class-of-drugs-for-heart-failure-sglt2-inhibitors-reduce-sympathetic-overactivity
#2
REVIEW
Motoaki Sano
Even in the presence of excess glucose, the proximal renal tubules continue to resorb more glucose. Sodium glucose cotransporter 2 (SGLT2) inhibitors are drugs that control this "greed" (H. Ito, Keio University, Japan). Negative feedback mechanisms maintain homeostasis for various physiological functions. However, there is no negative feedback mechanism for resorption of glucose by the proximal renal tubules. When food was scarce during human evolution, not limiting nutrient reabsorption was advantageous for survival, but the opposite is true in the era of satiation...
February 4, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29358024/the-association-between-relevant-co-morbidities-and-prevalent-as-well-as-incident-heart-failure-in-patients-with-atrial-fibrillation
#3
Per Wändell, Axel C Carlsson, Martin J Holzmann, Johan Ärnlöv, Jan Sundquist, Kristina Sundquist
BACKGROUND: Congestive heart failure (CHF) is a serious complication in patients with atrial fibrillation (AF). OBJECTIVE: To study associations between relevant co-morbidities and CHF in patients with AF. METHODS: Study population included all adults (n=12,283) ≥45 years diagnosed with AF at 75 primary care centers in Sweden 2001-2007. Logistic regression was used to calculate odds ratios with 95% confidence intervals (CIs) for the associations between co-morbidities, and prevalent CHF...
January 18, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29358023/surgical-strategy-and-outcomes-for-the-delayed-diagnosis-of-pulmonary-atresia-with-intact-ventricular-septum
#4
Xiaomin He, Botao Gao, Guocheng Shi, Huiwen Chen, Xinwei Du, Zhiwei Xu, Jinfen Liu, Zhongqun Zhu, Jinghao Zheng
BACKGROUND: In the present study, we summarize the experiences and evaluate clinical outcomes for the delayed diagnosis of pulmonary atresia with intact ventricular septum (PAIVS) patients when undergoing an initial visit and diagnosis in our heart center. METHODS: Fifty-eight cases of delayed diagnosis of PAIVS in patients aged more than 6 months between January 2006 and June 2016 were reviewed in our hospital. The median age at initial diagnosis was 12.2 months (range, 6...
January 18, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29338896/novel-bioabsorbable-polymer-and-polymer-free-metallic-drug-eluting-stents
#5
REVIEW
Jason Nogic, Liam M McCormick, Rohin Francis, Nitesh Nerlekar, Catherine Jaworski, Nick E J West, Adam J Brown
The introduction of drug-eluting stents (DES) significantly reduced angiographic restenosis and the clinical need for revascularization following percutaneous coronary intervention. However, concerns remain regarding the long-term safety and efficacy of DES. The use of durable polymers for drug elution that have limited biocompatibility is thought to contribute toward DES failure, by promoting an adverse local inflammatory response and vascular toxicity. Biodegradable polymer and polymer-free metallic stents represent two novel technological solutions to this challenging clinical problem...
January 12, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29338895/feasibility-of-total-intravenous-anesthesia-by-cardiologists-with-the-support-of-anesthesiologists-during-catheter-ablation-of-atrial-fibrillation
#6
Takanori Yamaguchi, Yusuke Shimakawa, Shinji Mitsumizo, Akira Fukui, Yuki Kawano, Toyokazu Otsubo, Yuya Takahashi, Kei Hirota, Takeshi Tsuchiya, Kenichi Eshima
BACKGROUND: The optimal methodology for sedation and anesthesia during atrial fibrillation (AF) ablation has not been well established. We assessed the feasibility of total intravenous anesthesia (TIVA) by cardiologists with support from anesthesiologists during AF ablation and quality of pulmonary vein isolation (PVI) and single procedure success rate at 12 months. METHODS: TIVA was performed by cardiologists using IV propofol and fentanyl under controlled ventilation via i-gel™ without neuromuscular blocking drugs in 160 consecutive patients (80 nonparoxysmal) with no anticipated difficult airway or other severe diseases...
January 12, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29331221/mechanisms-of-changes-in-functional-mitral-regurgitation-by-preload-alterations
#7
Atsuko Furukawa, Yukio Abe, Kazato Ito, Shingo Hosogi, Katsuhito Yamamoto, Hiroshi Ito
BACKGROUND: This study aimed to investigate the mechanisms of acute changes in functional mitral regurgitation (FMR) by preload alterations. METHODS: Twenty-two consecutive patients with left ventricular ejection fraction <40% and at least mild FMR underwent transthoracic echocardiography. Passive leg lifting and sublingual administration of nitroglycerin were performed to alter preload. Mitral regurgitant volume (MRV) was assessed using the Doppler method. RESULTS: MRV changed in parallel with preload alterations...
January 10, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29317133/ability-of-the-prognostic-model-of-j-access-study-to-predict-cardiac-events-in-a-clinical-setting-the-approach-study
#8
Isao Aburadani, Kazuo Usuda, Hisashi Sumiya, Satoru Sakagami, Hiroaki Kiyokawa, Shinro Matsuo, Masayuki Takamura, Hisayoshi Murai, Shinichiro Takashima, Teppei Kitano, Koichi Okuda, Kenichi Nakajima
BACKGROUND: In patients with coronary artery disease (CAD), one of the risk models available in Japan was a multivariate risk prediction model based on a Japanese multicenter database: the Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS). The aim of this study was to clinically validate the accuracy of this risk model. METHODS: We evaluated the performance of the J-ACCESS model using data derived from the Assessment of the Predicted value of PROgnosis of cArdiaC events in Hokuriku (APPROACH) registry...
January 6, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29317132/author-s-reply
#9
LETTER
Birgid Gonska, Julia Seeger, Wolfgang Rottbauer, Jochen Wöhrle
No abstract text is available yet for this article.
January 6, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29305187/cardiac-arrest-and-ventricular-arrhythmia-in-adults-with-ebstein-anomaly-and-left-ventricular-non-compaction
#10
Magdalena Kumor, Magdalena Lipczyńska, Elzbieta Katarzyna Biernacka, Anna Klisiewicz, Anna Wójcik, Marek Konka, Katarzyna Kożuch, Piotr Szymański, Piotr Hoffman
BACKGROUND: Ebstein anomaly is a complex, congenital heart defect that is associated with a variety of cardiac abnormalities. Studies found a similar sarcomere gene mutation in patients with Ebstein anomaly (EA) and patients with isolated left ventricular non-compaction (LVNC). AIM: We aimed to show the prevalence of LVNC and its potential relationship with severe cardiac events (VT - ventricular tachycardia, cardiac arrest) in adult patients with EA. METHODS: We conducted a retrospective search of our institutional database from 2010 to 2014 for patients with EA and reviewed patients' medical records (age, sex, clinical presentation, electrocardiographic, echocardiographic, and CMR - cardiac magnetic resonance features)...
January 2, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29289431/guiding-the-percutaneous-mitral-valve-repair-by-real-time-three-dimensional-transesophageal-echocardiography-beyond-procedural-navigation
#11
EDITORIAL
Nozomi Watanabe
No abstract text is available yet for this article.
December 27, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29287809/a-novel-scoring-system-to-predict-delirium-and-its-relationship-with-the-clinical-course-in-patients-with-acute-decompensated-heart-failure
#12
Taiki Sakaguchi, Mayumi Watanabe, Chika Kawasaki, Itomi Kuroda, Haruhiko Abe, Motoo Date, Yasunori Ueda, Yoshio Yasumura, Yukihiro Koretsune
BACKGROUND: Delirium is known to be a poor prognostic factor in patients with acute decompensated heart failure (ADHF). The purpose of this study was to determine predictors of delirium on admission of ADHF patients, and to establish a scoring formula to identify patients at high risk for delirium. METHODS AND RESULTS: We recorded the Intensive Care Delirium Screening Checklist (ICDSC) score in 120 ADHF patients during their stay in the coronary care unit (CCU)...
December 26, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29287808/clinical-implications-of-hemodynamic-assessment-during-left-ventricular-assist-device-therapy
#13
REVIEW
Teruhiko Imamura, Ben Chung, Ann Nguyen, Gabriel Sayer, Nir Uriel
Left ventricular assist devices (LVADs) significantly improve outcomes of advanced heart failure patients. However, patients continue to have high readmission rates due to complications ranging from bleeding, thrombosis, heart failure, and infection. Considering that the hallmark benefit of LVAD therapy is improvement in hemodynamics (cardiac unloading and increased cardiac output), hemodynamic assessment on LVAD support is key to better understand these difficult complications and may serve as a tool to resolving them...
December 26, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29279291/initial-pathological-responses-of-second-generation-everolimus-eluting-stents-implantation-in-japanese-coronary-arteries-comparison-with-first-generation-sirolimus-eluting-stents
#14
Rika Kawakami, Hiroyuki Hao, Takahiro Imanaka, Masahiko Shibuya, Yasunori Ueda, Masahiko Tsujimoto, Hatsue Ishibashi-Ueda, Seiichi Hirota
BACKGROUND: The clinical benefit of second-generation drug-eluting stents (2nd DES) has been established, compared to first-generation drug-eluting stents (1st DES). However, pathological response after 2nd DES implantation remains unclear, particularly in the Japanese population. METHODS: Using specimens obtained by autopsy, we compared the histology between 2nd DES (41 sections) and 1st DES (38 sections) lesions within 1 year after stent implantation to evaluate early tissue reaction in Japanese patients...
December 23, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29275952/late-onset-of-atrial-fibrillation-in-patients-undergoing-mitral-valve-repair-for-type-ii-dysfunction
#15
Naonori Kawamoto, Tomoyuki Fujita, Satsuki Fukushima, Yusuke Shimahara, Yuta Kume, Yorihiko Matsumoto, Kizuku Yamashita, Junjiro Kobayashi
BACKGROUND: There are few reports regarding factors related to late-onset of atrial fibrillation (Af) after mitral valve repair, which can compromise long-term outcome. We analyzed the risk factors for late Af after mitral valve repair. METHODS AND RESULTS: Between 2001 and 2015, 318 patients (214 males; median, 57.7 years) underwent mitral valve repair for degenerative mitral insufficiency (MI) without concomitant aortic valve disease in our institute. Patients with a history of paroxysmal or chronic Af preoperatively were excluded...
December 21, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29275951/transfemoral-transcatheter-aortic-valve-implantation-and-aortic-calcification
#16
LETTER
Michael Spartalis, Eleni Tzatzaki, Antonios Athanasiou, Eleftherios Spartalis
No abstract text is available yet for this article.
December 21, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29246394/progression-of-pulmonary-artery-dilatation-in-patients-with-pulmonary-hypertension-coexisting-with-a-pulmonary-artery-aneurysm
#17
Satoshi Akagi, Kazufumi Nakamura, Toshihiro Sarashina, Kentaro Ejiri, Shingo Kasahara, Hiroshi Ito
BACKGROUND: Pulmonary artery (PA) dilatation is usually observed in patients with pulmonary hypertension (PH), but a PA aneurysm (PA diameter > 40mm) is rare. The difference between characteristics of patients with and those without progression of PA diameter remains poorly understood. We assessed the changes in PA diameter in patients with PH coexisting with and without a PA aneurysm. METHODS: We investigated the changes in PA diameter by multi-detector computed tomography performed twice with an interval of more than one year in 44 patients with PH...
December 12, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29208341/hemodynamic-correlates-of-nutritional-indexes-in-heart-failure
#18
Yu Horiuchi, Shuzou Tanimoto, Taishi Okuno, Jiro Aoki, Kazuyuki Yahagi, Yu Sato, Tetsu Tanaka, Keita Koseki, Kota Komiyama, Hiroyoshi Nakajima, Kazuhiro Hara, Kengo Tanabe
BACKGROUND: Malnutrition in heart failure (HF) is related to altered intestinal function, which could be due to hemodynamic changes. We investigated the usefulness of novel nutritional indexes in relation to hemodynamic parameters. METHODS: We retrospectively analyzed 139 HF patients with reduced ejection fraction who underwent right heart catheterization. We investigated correlations between right side pressures and nutritional indexes, which include controlling nutritional (CONUT) score and geriatric nutritional risk index (GNRI)...
December 2, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29208340/different-indicators-for-postprocedural-mitral-stenosis-caused-by-single-or-multiple-clip-implantation-after-percutaneous-mitral-valve-repair
#19
Yuji Itabashi, Hiroto Utsunomiya, Shunsuke Kubo, Yukiko Mizutani, Hirotsugu Mihara, Mitsushige Murata, Robert J Siegel, Saibal Kar, Keiichi Fukuda, Takahiro Shiota
BACKGROUND: Postprocedural mitral stenosis (MS) is a main limitation for MitraClip™ (Abbot Vascular, Inc., Santa Clara, CA, USA) procedure. The purpose of this study was to detect the preprocedural predictors of high transmitral pressure gradient (TMPG) after MitraClip™ implantation, which indicated postprocedural mitral stenosis (MS). METHODS: We studied 79 patients who were implanted with MitraClip™ in our institute. Before the procedure, mitral valve orifice area (MVOA), and anterior-posterior (AP) and medial-lateral (ML) mitral annular diameters were measured at diastole using three-dimensional (3D) transesophageal echocardiography (TEE) data set...
December 2, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29203080/diastolic-wall-strain-is-associated-with-incident-heart-failure-in-african-americans-insights-from-the-atherosclerosis-risk-in-communities-study
#20
Daisuke Kamimura, Takeki Suzuki, Michael E Hall, Wanmei Wang, Michael D Winniford, Amil M Shah, Carlos J Rodriguez, Kenneth R Butler, Thomas H Mosley
BACKGROUND: Increased left ventricular (LV) myocardial stiffness may be associated with impaired LV hemodynamics and incident heart failure (HF). However, an indicator that estimates LV myocardial stiffness easily and non-invasively is lacking. The purpose of this study was to determine whether diastolic wall strain (DWS), an echocardiographic estimator of LV myocardial stiffness, is associated with incident HF in a middle-aged community-based cohort of African Americans. METHODS AND RESULTS: We investigated associations between DWS and incident HF among 1528 African Americans (mean age 58...
December 1, 2017: Journal of Cardiology
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