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Neurophysiologie Clinique, Clinical Neurophysiology

Filippo Zappasodi, Gabriella Musumeci, Riccardo Navarra, Vincenzo Di Lazzaro, Massimo Caulo, Antonino Uncini
BACKGROUND AND OBJECTIVE: Application parameters of transcranial direct current stimulation (tDCS) for therapeutic purposes are relatively restricted. The aim of this study was to assess safety and effects on motor cortex excitability of an intensive anodal-tDCS protocol. METHODS: In 26 healthy subjects, five 15-minute anodal-tDCS sessions were delivered, at increasing time intervals, over 24hours. Safety was defined as absence of serious adverse events including brain tissue alterations on magnetic resonance imaging...
January 8, 2019: Neurophysiologie Clinique, Clinical Neurophysiology
Sophie Ng Wing Tin, Hela G Zouari, Samar S Ayache, Anne-Isabelle Tropeano, Christiane Ajzenberg, Jora Xhaxho, Abir Wahab, Jean-Pascal Lefaucheur, Alain Créange
OBJECTIVES: Metabolic abnormalities, such as, glycemic disorders and metabolic syndrome (GDMS) are one of the main causes of peripheral neuropathies. The objective of this study was to evaluate the impact of adding specific coaching care (CC) to standard care (SC) of therapeutic education based on lifestyle recommendations for neuropathies associated with GDMS. METHODS: This prospective randomized study included two groups of four patients (SC vs. CC) with examiners blinded to group allocation...
January 4, 2019: Neurophysiologie Clinique, Clinical Neurophysiology
Etienne Allart, Hervé Devanne, Arnaud Delval
Parietofrontal (PF) networks link the posterior parietal cortex to premotor and prefrontal areas, and are involved in the control of many motor and cognitive behaviors in healthy humans. In recent years, electrophysiological experiments have provided a better understanding of the functional specificity and temporal involvement of the PF networks' different components during the planning of visually guided upper limb movements. In particular, transcranial magnetic stimulation has been used to temporarily inactivate a cortical area (virtual lesions) or to assess connectivity using paired-pulse protocols))...
December 29, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Yosra Cherni, Geneviève Girardin-Vignola, Laurent Ballaz, Mickael Begon
BACKGROUND: The Lokomat (by L-Force tool) allows the measurement of the maximum voluntary isometric torque (MVIT) at the knee and hip joints in a standing position, as close as possible to the posture adopted during walking. However, the reliability of this measurement in children with cerebral palsy (CP) remains unknown. The main goal of this study was to evaluate inter and intra-tester reliability of a novel tool (L-Force) in CP population. PROCEDURE: L-Force reliability was determined in 17 children with CP by two experienced therapists...
December 23, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Catarina Falcão de Campos, Pedro Viana, Isabel de Castro, José Castro, Mamede de Carvalho, Isabel Conceição
OBJECTIVES: Myasthenia gravis (MG) is an autoimmune disease associated with antibodies against the nicotinic muscle acetylcholine receptor (AChR) at the neuromuscular junction. Dysautonomia has been previously described in MG. Electrochemical skin conductance (ESC), assessed by Sudoscan® , is a non-invasive method that allows evaluation of sudomotor function. Since sweat glands are innervated by sudomotor, postganglionic, cholinergic sympathetic C-fibers, we hypothesized that ESC could be a reliable method for assessing autonomic dysfunction in MG...
December 13, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Jan Rosner, Janosch Rinert, Mario Ernst, Armin Curt, Michèle Hubli
INTRODUCTION: Cold evoked potentials (CEPs) represent a novel technique to assess the integrity of cold-specific pathways within the somatosensory system. So far an objective assessment of these pathways has not been implemented into the clinical routine. Specifically, CEPs may help to elucidate the pathophysiological underpinnings of altered cold processing in neurological diseases. OBJECTIVE: To test feasibility and test-retest reliability of CEPs within two cervical dermatomes, including recording sites in glabrous and hairy skin, in order to facilitate the transition into clinical practice...
December 11, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Julien Grandjean, Caroline Quoilin, Julie Duque
OBJECTIVES: Motor-evoked potentials (MEPs) to transcranial magnetic stimulation (TMS) show a profound suppression when elicited during the instructed-delay of reaction time (RT) tasks. One predominant hypothesis is that this phenomenon, called "preparatory inhibition", reflects the operation of processes that suppress motor activity to withhold prepared (but delayed) responses, a form of impulse control. In addition, a startling acoustic stimulus (SAS) - a loud and narrow sound - can trigger the release of prepared responses in RT tasks...
December 5, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Anne Sauvaget, Agathe Tostivint, François Etcheverrigaray, Anne Pichot, Cécile Dert, Solène Schirr-Bonnais, Johann Clouet, Olivier Sellal, Nicolas Mauduit, Christophe Leux, Clémence Cabelguen, Samuel Bulteau, Valéry-Pierre Riche
OBJECTIVES: Due to its ease of use, tolerance, and cost of acquisition, transcranial direct current stimulation (tDCS) could constitute a credible therapeutic option for non-resistant depression in primary care, when combined with drug management. This indication has yet to receive official recognition in France. The objective of this study is to evaluate the production cost of tDCS for the treatment of depression in hospitals, under realistic conditions. METHODS: The methodology adopted is based on cost accounting and was validated by a multidisciplinary working group...
November 27, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Camille Jeunet, Bertrand Glize, Aileen McGonigal, Jean-Marie Batail, Jean-Arthur Micoulaud-Franchi
Many Brain Computer Interface (BCI) and neurofeedback studies have investigated the impact of sensorimotor rhythm (SMR) self-regulation training procedures on motor skills enhancement in healthy subjects and patients with motor disabilities. This critical review aims first to introduce the different definitions of SMR EEG target in BCI/Neurofeedback studies and to summarize the background from neurophysiological and neuroplasticity studies that led to SMR being considered as reliable and valid EEG targets to improve motor skills through BCI/neurofeedback procedures...
November 7, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Charlotte Brevet-Aeby, Marine Mondino, Emmanuel Poulet, Jérome Brunelin
OBJECTIVE: We aimed to investigate whether the number of sessions delivered within one day influences the acute and long-term effects of transcranial random noise stimulation (tRNS) applied over the dorsolateral prefrontal cortex (DLPFC) on inhibitory control. METHODS: Thirty-six healthy participants were randomly assigned to receive either (i) 3 active (3A), (ii) 1 active and 2 sham (1A2S) or (iii) 3 sham (3S) tRNS sessions. The 3 tRNS were delivered consecutively in the same half-day separated by 30min with the anode over the right and the cathode over the left DLPFC...
November 7, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Julia Birchenall, Maxime Térémetz, Pauline Roca, Jean-Charles Lamy, Catherine Oppenheim, Marc A Maier, Jean-Louis Mas, Catherine Lamy, Jean-Claude Baron, Påvel G Lindberg
OBJECTIVES: In this longitudinal pilot study, we investigated how manual dexterity recovery was related to corticospinal tract (CST) injury and excitability, in six patients undergoing conventional rehabilitation. METHODS: Key components of manual dexterity, namely finger force control, finger tapping rate and independence of finger movements, were quantified. Structural MRI was obtained to calculate CST lesion load. CST excitability was assessed by measuring rest motor threshold (RMT) and the amplitude of motor evoked potentials (MEPs) using transcranial magnetic stimulation (TMS)...
October 31, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Eman M Khedr, Bastawy Al Fawal, Ahmed M Abdelwarith, Mostafa Saber, Abeer Abdel Hady Tony, Ahmed El-Bassiony, John C Rothwell
OBJECTIVES: It has recently been suggested that drug-induced tardive syndromes (TS) might be due to maladaptive plasticity, which increases motor excitability in cerebral cortex and basal ganglia. In order to test this hypothesis, we performed the first measurements of cortical excitability in TS. METHODS: Motor cortex excitability was examined using transcranial magnetic stimulation (TMS) in 22 TS patients and compared with that in 20 age and sex-matched healthy individuals...
October 23, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Madli Bayot, Kathy Dujardin, Céline Tard, Luc Defebvre, Cédrick T Bonnet, Etienne Allart, Arnaud Delval
Studies of dual-tasks (i.e. situations during which an individual performs two tasks simultaneously) and the subsequent inter-task interference have shown that locomotion and posture involves motor and cognitive components. Dual-tasks therefore constitute a promising avenue for improving the diagnosis, prevention and management of falls or cognitive impairment in populations at risk. However, tackling these major public health concerns with dual-task interventions requires a better understanding of the mechanisms underlying dual-task interference...
December 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Gilles Allali, Helena M Blumen, Hervé Devanne, Elvira Pirondini, Arnaud Delval, Dimitri Van De Ville
Impaired locomotion is a frequent and major source of disability in patients with neurological conditions. Different neuroimaging methods have been used to understand the brain substrates of locomotion in various neurological diseases (mainly in Parkinson's disease) during actual walking, and while resting (using mental imagery of gait, or brain-behavior correlation analyses). These studies, using structural (i.e., MRI) or functional (i.e., functional MRI or functional near infra-red spectroscopy) brain imaging, electrophysiology (i...
December 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Simone Dalla Bella
Rhythmic abilities are highly widespread in the general population. Most people can extract the regular beat of music, and align their movements with it. The aim of a translational approach for music and movement is to build on current fundamental research and theories of beat perception and synchronization to devise music-based interventions, which are informed by theory. To illustrate this approach, Parkinson's disease is taken as a model, with a focus on the positive effects of rhythmic auditory cueing on walking...
December 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Ewa Zalewska, Malgorzata Gawel
OBJECTIVES: The aim of our study was to verify the effectiveness of single fiber potential (SFP) criteria in cases when the potential recorded using single fiber electrode (SFE) or concentric needle electrode (CNE) is contaminated by distant fibers. METHODS: Morphological counterparts of SFP were studied using computer simulations. In this study, we examined triphasic potentials using a model of a linear source of SFP. The criteria defining SFP in the case of SFP contaminated by distant fibers were analyzed, and the effect of second fiber contamination on jitter and fiber diameter determination evaluated...
October 13, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Tharapong Prajongkit, Montida Veeravigrom, Rujipat Samransamruajkit
OBJECTIVE: To determine the prognostic value of continuous electroencephalography (EEG) in children undergoing therapeutic hypothermia after cardiac arrest. METHOD: We retrospectively reviewed medical records and continuous EEG of all patients undergoing therapeutic hypothermia after cardiac arrest from November 2013 to September 2016. Demographic, clinical data and immediate complications were collected. Characteristics of continuous EEG including EEG background, time to normal trace (TTNT) and electrographic seizures were reviewed by investigators...
October 12, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Farzad Fatehi, Aude-Marie Grapperon, Davood Fathi, Emilien Delmont, Shahram Attarian
The need for a valid biomarker for assessing disease progression and for use in clinical trials on amyotrophic lateral sclerosis (ALS) has stimulated the study of methods that could measure the number of motor units. Motor unit number index (MUNIX) is a newly developed neurophysiological technique that was demonstrated to have a good correlation with the number of motor units in a given muscle, even though it does not necessarily accurately express the actual number of viable motor neurons. Several studies demonstrated the technique is reproducible and capable of following motor neuron loss in patients with ALS and peripheral polyneuropathies...
October 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Laure Peter-Derex, Hélène Catenoix, Hélène Bastuji, Florian Chouchou
OBJECTIVE: Differential diagnosis between sleep-related epileptic seizures and NREM parasomnia remains challenging. Pathophysiological markers to differentiate both conditions are needed. Activation of autonomic system is present in arousal reactions and epileptic seizures. Our study investigated whether cardiac reactivity differed between arousal disorders and sleep-related seizures. METHODS: Nocturnal recordings of 50 patients (10 in each group: frontal lobe epilepsy [FLE], temporal lobe epilepsy [TLE], nocturnal terror [NT], confusional arousal [CA], normal arousals [NA]) were retrospectively selected...
September 15, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Frederic Viseux, Franck Barbier, Philippe Villeneuve, Antoine Lemaire, Pascal Charpentier, Sebastien Leteneur
The purpose of the study was to evaluate the effect of an additional thickness placed under the toes (TUT) on the CoP measures and to determine the optimum thickness required to maximize the postural control performance. Four conditions were compared: TUT 0 (control), 0.8, 3, and 6mm and four variables were computed from the CoP displacements. These results suggest that the lowest TUT could contribute to changing balance control, and may have clinical interest. This brings perspectives in the management of patients with risk of falling or with chronic pain syndromes, complementing validated therapeutic strategies...
September 5, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
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