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FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology

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https://www.readbyqxmd.com/read/30433825/gut-microbiota-development-in-mice-is-affected-by-hydrogen-peroxide-produced-from-amino-acid-metabolism-during-lactation
#1
Yuko Shigeno, Haolin Zhang, Taihei Banno, Kento Usuda, Tomonori Nochi, Ryo Inoue, Gen Watanabe, Wanzhu Jin, Yoshimi Benno, Kentaro Nagaoka
The development of gut microbiota during infancy is an important event that affects the health status of the host; however, the mechanism governing it is not fully understood. l-Amino acid oxidase 1 (LAO1) is a flavoprotein that catalyzes the oxidative deamination of particular l-amino acids and converts them into keto acids, ammonia, and H2 O2 . Our previous study showed that LAO1 is present in mouse milk and exerts protection against bacteria by its production of H2 O2 . The data led us to consider whether LAO1, H2 O2 , or both could impact infant gut microbiota development via mother's milk consumption in mice...
November 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30423262/exogenous-adrenocorticotropic-hormone-affects-genome-wide-dna-methylation-and-transcriptome-of-corpus-luteum-in-sows
#2
Fang Zhao, Wangjun Wu, Quanwei Wei, Ming Shen, Bojiang Li, Yi Jiang, Kaiqing Liu, Honglin Liu
Stress is known to cause corpus luteum (CL) dysfunction, and stress hormones play a critical role in this process. However, the mechanism remains unclear. In this study, weaned sows were injected with synthetic adrenocorticotropic hormone (ACTH) for 7 d; whole-genome bisulfite sequencing (WGBS) and RNA-sequencing was used respectively to investigate the systematic association between ACTH administration and DNA methylation in CL and its relationship to gene expression. Results showed that ACTH treatment significantly increased the concentrations of cortisol ( P < 0...
November 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30423261/the-rna-binding-protein-lin28-controls-progenitor-and-neuronal-cell-fate-during-postnatal-neurogenesis
#3
Jennifer S Romer-Seibert, Nathaniel W Hartman, Eric G Moss
The RNA-binding protein LIN28 is known to regulate cell fate, tissue growth, and pluripotency; however, a unified understanding of its role at the cellular level has not been achieved. Here, we address its developmental activity in mammalian postnatal neurogenesis. Constitutive expression of LIN28 in progenitor cells of the mouse subventricular zone (SVZ) caused several distinct effects: 1) the number of differentiated neurons in the olfactory bulb was dramatically reduced, whereas the relative abundance of 2 neuronal subtypes was significantly altered, 2) the population of proliferating neural progenitors in the SVZ was reduced, whereas the proportion of neuroblasts was increased, and 3) the number of astrocytes was reduced, occasionally causing them to appear early...
November 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30423260/hyperglycemia-promotes-microvillus-membrane-expression-of-dmt1-in-intestinal-epithelial-cells-in-a-pkc%C3%AE-dependent-manner
#4
Luqing Zhao, Thomas Bartnikas, Xiangpeng Chu, Janet Klein, Chris Yun, Shanthi Srinivasan, Peijian He
Excessive iron increases the incidence of diabetes and worsens diabetic complications. Reciprocally, diabetes induces iron loading, partially attributable to elevated intestinal iron export according to a recent report. Herein, we show that iron uptake and the mRNA expression of iron importer divalent metal transporter 1 (DMT1) were significantly increased in the duodenum of streptozotocin-induced diabetic mice. Immunofluorescence staining of human intestinal biopsies revealed increased brush border membrane (BBM) and decreased cytoplasmic DMT1 expression in patients with diabetes, suggesting translocation of DMT1...
November 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30423259/identification-of-a-novel-caspase-cleavage-site-in-huntingtin-that-regulates-mutant-huntingtin-clearance
#5
Dale D O Martin, Mandi E Schmidt, Yen T Nguyen, Nikola Lazic, Michael R Hayden
Huntington disease (HD) is a progressive neurodegenerative disease that initially affects the striatum and leads to changes in behavior and loss of motor coordination. It is caused by an expansion in the polyglutamine repeat at the N-terminus of huntingtin (HTT) that leads to aggregation of mutant HTT. The loss of wild-type function, in combination with the toxic gain of function mutation, initiates various cell death pathways. Wild-type and mutant HTT are regulated by different posttranslational modifications that can positively or negatively regulate their function or toxicity...
November 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30407878/gdf11-antagonizes-tnf-%C3%AE-induced-inflammation-and-protects-against-the-development-of-inflammatory-arthritis-in-mice
#6
Weiwei Li, Wenhan Wang, Long Liu, Ruize Qu, Xiaomin Chen, Cheng Qiu, Jiayi Li, John Hayball, Liang Liu, Jianying Chen, Xia Wang, Xin Pan, Yunpeng Zhao
Growth differentiation factor 11 (GDF11), a key member of the TGF-β superfamily, plays critical roles in various medical conditions. Recently, GDF11 was found to suppress the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway and protect against inflammation. This study aimed to investigate the role of GDF11 in the development of rheumatoid arthritis (RA). We demonstrated that GDF11 treatment antagonized TNF-α-induced inflammation in macrophages. Moreover, GDF11 inhibited the development of arthritis in the collagen-induced arthritis and collagen antibody-induced arthritis models...
November 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30407877/direct-sumoylation-of-m1-muscarinic-acetylcholine-receptor-increases-its-ligand-binding-affinity-and-signal-transduction
#7
Jianrong Xu, Panpan Tan, Hui Li, Yongyao Cui, Yu Qiu, Hao Wang, Xuan Zhang, Juan Li, Liang Zhu, Wei Zhou, Hongzhuan Chen
SUMOylation is a significant post-translational modification (PTM) by the small ubiquitin-related modifier (SUMO). Increasing evidence shows SUMOylation regulates GPCR signaling; however, very few GPCRs have been shown to be SUMOylation targets to date. In this study, we identified M1 muscarinic acetylcholine receptor (M1 mAChR), a member of the GPCRs, as a new SUMO substrate. When the mAChR was activated by the agonist carbachol, the colocalization of the M1 mAChR and SUMO-1 protein markedly decreased in immunoprecipitation and immunofluorescence assays...
November 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30403537/3d-human-bone-marrow-stromal-and-endothelial-cell-spheres-promote-bone-healing-in-an-osteogenic-niche
#8
Stefanie Inglis, Janos M Kanczler, Richard O C Oreffo
The current study used an ex vivo [embryonic day (E)18] chick femur defect model to examine the bone regenerative capacity of implanted 3-dimensional (3D) skeletal-endothelial cell constructs. Human bone marrow stromal cell (HBMSC) and HUVEC spheroids were implanted within a bone defect site to determine the osteogenic potential of the skeletal-endothelial cell unit. Cells were pelleted as co- or monocell spheroids and placed within 1-mm-drill defects in the mid-diaphysis of E18 chick femurs and cultured organotypically for 10 d...
November 7, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30399323/nape-pld-controls-oea-synthesis-and-fat-absorption-by-regulating-lipoprotein-synthesis-in-an-in-vitro-model-of-intestinal-epithelial-cells
#9
Miki Igarashi, Kazuhide Watanabe, Tsuyoshi Tsuduki, Ikuo Kimura, Naoto Kubota
Oleoylethanolamide (OEA), a fatty acid ethanolamide (FAE), is a lipid mediator that controls food intake and lipid metabolism. Accumulating data imply the importance of intestinal OEA in controlling satiety in addition to gastrointestinal peptide hormones. Although the biochemical pathway of FAE production has been illustrated, the enzymes responsible for the cleavage of OEA from its precursor N-acyl-phosphatidylethanolamine (NAPE) must be identified among reported candidates in the gut. In this study, we assessed the involvement of NAPE-specific phospholipase D (NAPE-PLD), which can directly release FAEs from NAPE, in intestinal OEA synthesis and lipid metabolism...
November 6, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30383452/genetic-ablation-of-nfat5-tonebp-in-smooth-muscle-cells-impairs-flow-and-pressure-induced-arterial-remodeling-in-mice
#10
Caroline Arnold, Anja Feldner, Maren Zappe, Dorde Komljenovic, Carolina De La Torre, Philipp Ruzicka, Markus Hecker, Wolfgang Neuhofer, Thomas Korff
The arterial wall adapts to alterations in blood flow and pressure by remodeling the cellular and extracellular architecture. Biomechanical stress of vascular smooth muscle cells (VSMCs) in the media is thought to precede this process and promote their activation and subsequent proliferation. However, molecular determinants orchestrating the transcriptional phenotype under these conditions have been insufficiently studied. We identified the transcription factor, nuclear factor of activated T cells 5 (NFAT5; or tonicity enhancer-binding protein) as a crucial regulatory element of mechanical stress responses of VSMCs...
November 1, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30383451/fas-receptor-induces-apoptosis-of-synovial-bone-and-cartilage-progenitor-populations-and-promotes-bone-loss-in-antigen-induced-arthritis
#11
Elvira Lazić Mosler, Nina Lukač, Darja Flegar, Martina Fadljević, Igor Radanović, Hrvoje Cvija, Tomislav Kelava, Sanja Ivčević, Alan Šućur, Antonio Markotić, Vedran Katavić, Ana Marušić, Danka Grčević, Nataša Kovačić
Rheumatoid arthritis (RA) is inflammatory joint disease that eventually leads to permanent bone and cartilage destruction. Fas has already been established as the regulator of inflammation in RA, but its role in bone formation under arthritic conditions is not completely defined. The aim of this study was to assess the effect of Fas inactivation on the bone damage during murine antigen-induced arthritis. Subchondral bone of wild-type (WT) and Fas-knockout (Fas-/- ) mice was evaluated by histomorphometry and microcomputerized tomography...
November 1, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30383450/bmp7-antagonizes-proliferative-vitreoretinopathy-through-retinal-pigment-epithelial-fibrosis-in-vivo-and-in-vitro
#12
Haipei Yao, Tandi Ge, Yao Zhang, Min Li, Shuai Yang, Hui Li, Fang Wang
The major pathogenesis of proliferative vitreoretinopathy (PVR) is that retinal pigment epithelial (RPE) cells undergo epithelial-mesenchymal transition (EMT) because of disordered growth factors, such as TGF-β, in the vitreous humor. Bone morphogenetic proteins (BMPs) are pluripotent growth factors. In this study, we identified the antifibrotic activity of BMP7 in a PVR model both in vivo and in vitro. BMP7 expression was confirmed on the PVR proliferative membranes. BMP7 was down-regulated in the PVR vitreous humor and TGF-β-induced RPE cell EMT...
November 1, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30383449/rna-stability-protein-ilf3-mediates-cytokine-induced-angiogenesis
#13
Christine N Vrakas, Allison B Herman, Mitali Ray, Sheri E Kelemen, Rosario Scalia, Michael V Autieri
Interleukin enhancer-binding factor 3 (ILF3), an RNA-binding protein, is best known for its role in innate immunity by participation in cellular antiviral responses. A role for ILF3 in angiogenesis is unreported. ILF3 expression in CD31+ capillaries of hypoxic cardiac tissue was detected by immunohistochemistry. Proangiogenic stimuli induce ILF3 mRNA and protein expression in cultured human coronary artery endothelial cells (hCAECs). Angiogenic indices, including proliferation, migration, and tube formation, are all significantly reduced in hCAECs when ILF3 is knocked down using small interfering RNA (siRNA), but are significantly increased when ILF3 is overexpressed using adenovirus...
November 1, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30383448/cd8-but-not-cd4-effector-memory-t-cells-express-the-cd44-high-cd45rb-high-phenotype-with-aging-which-displays-reduced-expression-levels-of-p2x-7-receptor-and-atp-induced-cellular-responses
#14
Amine Mellouk, Pierre Bobé
Previously we reported that the sensitivity of CD4+ T cells to ATP does not depend on P2X7 receptor (P2X7 R) expression levels but on their activation and differentiation stages. Therefore, here we have investigated a potential relationship between the sensitivity of CD8+ T cells to ATP and their stages of differentiation. Thus, the CD8+ subpopulation exhibits a drastically reduced sensitivity to ATP with aging, which parallels the strong increase of an effector/memory CD8+ subset expressing high levels of CD44 cell adhesion molecule and CD45RB transmembrane phosphatase (CD44hi CD45RBhi )...
November 1, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30383447/lack-of-acute-xenogeneic-graft-versus-host-disease-but-retention-of-t-cell-function-following-engraftment-of-human-peripheral-blood-mononuclear-cells-in-nsg-mice-deficient-in-mhc-class-i-and-ii-expression
#15
Michael A Brehm, Laurie L Kenney, Michael V Wiles, Benjamin E Low, Roland M Tisch, Lisa Burzenski, Christian Mueller, Dale L Greiner, Leonard D Shultz
Immunodeficient mice engrafted with human peripheral blood mononuclear cells (PBMCs) support preclinical studies of human pathogens, allograft rejection, and human T-cell function. However, a major limitation of PBMC engraftment is development of acute xenogeneic graft- versus-host disease (GVHD) due to human T-cell recognition of murine major histocompatibility complex (MHC). To address this, we created 2 NOD- scid IL-2 receptor subunit γ ( IL2rg) null (NSG) strains that lack murine MHC class I and II [NSG-β-2-microglobulin ( B2M) null ( IA IE)null and NSG -( Kb Db ) null ( IAnull )]...
November 1, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30383446/dietary-omega-3-fatty-acids-alter-the-lipid-mediator-profile-and-alleviate-allergic-conjunctivitis-without-modulating-t-h-2-immune-responses
#16
Toshiaki Hirakata, Hyeon-Cheol Lee, Mai Ohba, Kazuko Saeki, Toshiaki Okuno, Akira Murakami, Akira Matsuda, Takehiko Yokomizo
Allergic conjunctivitis (AC) is one of the most common ocular surface diseases in the world. In AC, T helper type 2 (Th 2) immune responses play central roles in orchestrating inflammatory responses. However, the roles of lipid mediators in the onset and progression of AC remain to be fully explored. Although previous reports have shown the beneficial effects of supplementation of ω-3 fatty acids in asthma or atopic dermatitis, the underlying molecular mechanisms are poorly understood. In this study, a diet rich in ω-3 fatty acids alleviated AC symptoms in both early and late phases without affecting Th 2 immune responses, but rather by altering the lipid mediator profiles...
November 1, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30383439/young-plasma-attenuates-age-dependent-liver-ischemia-reperfusion-injury
#17
Anding Liu, Jiankun Yang, Qi Hu, Olaf Dirsch, Uta Dahmen, Cuntai Zhang, David A Gewirtz, Haoshu Fang, Jian Sun
Aging is often associated with a decreased autophagic activity that contributes to the high sensitivity of aged livers to ischemia reperfusion injury (IRI). Blood from young animals can positively affect aged animals. This study was designed to evaluate the effect of young plasma in a model of liver IRI in aged rats. Aged rats were treated with pooled plasma collected from young rats before ischemia. Administration of young plasma restored aging-induced suppression in hepatic autophagic activity and reduced liver IRI...
November 1, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30379590/pro-proliferative-function-of-adaptor-protein-grb10-in-prostate-carcinoma
#18
Mohammad Imran Khan, Ahmed Al Johani, Abid Hamid, Bushra Ateeq, Nishat Manzar, Vaqar Mustafa Adhami, Rahul K Lall, Suvasmita Rath, Mario Sechi, Imtiaz Ahmad Siddiqui, Hani Choudhry, Mazin A Zamzami, Thomas C Havighurst, Wei Huang, James M Ntambi, Hasan Mukhtar
Growth factor receptor-binding protein 10 (GRB10) is a well-known adaptor protein and a recently identified substrate of the mammalian target of rapamycin (mTOR). Depletion of GRB10 increases insulin sensitivity and overexpression suppresses PI3K/Akt signaling. Because the major reason for the limited efficacy of PI3K/Akt-targeted therapies in prostate cancer (PCa) is loss of mTOR-regulated feedback suppression, it is therefore important to assess the functional importance and regulation of GRB10 under these conditions...
October 31, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30376360/thy1-cd90-expression-is-regulated-by-dna-methylation-during-adipogenesis
#19
E'Lissa M Flores, Collynn F Woeller, Megan L Falsetta, Martha Susiarjo, Richard P Phipps
The obesity epidemic is developing into the most costly health problem facing the world. Obesity, characterized by excessive adipogenesis and enlarged adipocytes, promotes morbidities, such as diabetes, cardiovascular disease, and cancer. Regulation of adipogenesis is critical to our understanding of how fat cell formation causes obesity and associated health problems. Thy1 (also called CD90), a widely used stem cell marker, blocks adipogenesis and reduces lipid accumulation. Thy1-knockout mice are prone to diet-induced obesity...
October 30, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30376359/dihydrodaidzein-and-6-hydroxydaidzein-mediate-the-fermentation-induced-increase-of-anti-osteoporotic-effect-of-soybeans-in-ovariectomized-mice
#20
Ji-Sun Kim, Hyunjung Lee, Farida Sukma Nirmala, Chang Hwa Jung, Min Jung Kim, Young-Jin Jang, Tae Youl Ha, Jiyun Ahn
The consumption of soybeans is known to have beneficial effects on osteoporosis in postmenopausal women. However, the effects of soybean fermentation on the bioavailability and the anti-osteoporotic effect have not yet been elucidated. To address this question, we fed ovariectomized C57BL/6J mice with a 5% nonfermented raw soybean (RS)- or fermented soybean (FS)-supplemented diet. After 18 wk of treatment, microcomputed tomography showed that FSs significantly increased bone mineral density compared with RSs...
October 30, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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