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European Journal of Clinical Microbiology & Infectious Diseases

Niclas Johansson, Martin Vondracek, Carolina Backman-Johansson, Magnus C Sköld, Karin Andersson-Ydsten, Jonas Hedlund
The aim of this study was to use a 16S rDNA sequencing method in combination with conventional culture in patients with parapneumonic effusions (PPE) to evaluate the methods, study the microbiological spectrum, and examine the presence of bacteria within the different stages of PPE. Adults with community-acquired pneumonia (CAP) and PPE (n = 197) admitted to the Departments of Infectious Diseases at four hospitals in Stockholm County during 2011-2014 were prospectively studied. All patients underwent thoracentesis...
December 13, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Moonsuk Bae, Hae In Kim, Joung Ha Park, Byung-Han Ryu, Jeonghyun Chang, Heungsup Sung, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Mi-Na Kim, Yong Pil Chong
The introduction of dedicated phlebotomy teams certified for blood collection has been reported to be highly cost-effective by reducing contamination rates. However, data on their effects on blood volume and true positive rate are limited. Therefore, we investigated the effect of replacing interns with a phlebotomy team on blood culture results. We performed a 24-month retrospective, quasi-experimental study before and after the introduction of a phlebotomy team dedicated to collecting blood cultures in a 2700-bed tertiary-care hospital...
December 7, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Andrew Kirby, Eduardo Asín-Prieto, Flora Agnes Burns, Duncan Ewin, Kavi Fatania, Mithun Kailavasan, Saira Nisar, Agamemnon Pericleous, Iñaki F Trocóniz, Dermot Burke
Standard bolus-dosed antibiotic prophylaxis may not inhibit growth of antibiotic resistant colonic bacteria, a cause of SSIs after colorectal surgery. An alternative strategy is continuous administration of antibiotic throughout surgery, maintaining concentrations of antibiotics that inhibit growth of resistant bacteria. This study is a pilot comparing bolus-continuous infusion with bolus-dosed cefuroxime prophylaxis in colorectal surgery. This is a pilot randomised controlled trial in which participants received cefuroxime bolus-infusion (intervention arm) targeting free serum cefuroxime concentrations of 64 mg/L, or 1...
December 5, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Stéphanie Le Page, Gregory Dubourg, Sophie Alexandra Baron, Jean-Marc Rolain, Didier Raoult
Since effective empirical antibiotic therapy is a key factor for survival, local antibiotic resistance epidemiology is critical. We aimed to identify current trends in antibiotic resistance for key antibiotics obtained over 16 years (2001-2016) for invasive infections corresponding to empirical treatment in a large hospital centre in Marseille, France.From January 2014 to December 2016, we have collected all data on antibiotic susceptibility from public laboratory hospitals, and a retrospective analysis was performed on key antibiotics in blood cultures since 2001...
December 4, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Daniele Roberto Giacobbe, Alessio Signori, Mario Tumbarello, Riccardo Ungaro, Giovanni Sarteschi, Elisa Furfaro, Malgorzata Mikulska, Maurizio Sanguinetti, Brunella Posteraro, Angela Raffaella Losito, Gennaro De Pascale, Valerio Del Bono, Claudio Viscoli
Desirability of outcome ranking (DOOR) has been developed for assessing desirability of outcome in interventional studies. However, its possible use in observational studies of the diagnosis and early treatment of infectious diseases has not been explored so far, and it might introduce interesting features in specific scenarios. This was a post hoc analysis of a prospective observational study in intensive care unit patients with sepsis and at risk of candidemia. The probabilities that a randomly selected patient would have a more, less, and equally cost-effective early therapeutic choice following a BDG-based diagnostic strategy rather than the empirical administration of antifungals to all patients were calculated using DOOR methods...
November 30, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Fanny Mathias, Christophe Curti, Marc Montana, Charléric Bornet, Patrice Vanelle
Clostridium difficile infections (CDI) dramatically increased during the last decade and cause a major public health problem. Current treatments are limited by the high disease recurrence rate, severity of clinical forms, disruption of the gut microbiota, and colonization by vancomycin-resistant enterococci (VRE). In this review, we resumed current treatment options from official recommendation to promising alternatives available in the management of adult CDI, with regard to severity and recurring or non-recurring character of the infection...
November 29, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Marie-Hélène Nicolas-Chanoine, Marie Vigan, Cédric Laouénan, Jérôme Robert
This study aimed to assess characteristics associated with infections due to carbapenem-resistant Enterobacteriaceae (CRE), producing (CPE) or not producing (non-CPE) carbapenemase, among hospitalised patients in 2014-2016 in France. Case-patients with CRE were compared to two control populations. In multivariate analysis comparing 160 CRE cases to 160 controls C1 (patients with a clinical sample positive for carbapenem-susceptible Enterobacteriaceae), five characteristics were linked to CRE: male gender (OR = 1...
November 28, 2018: European Journal of Clinical Microbiology & Infectious Diseases
David B Huang, Jee Hyun Park, Timothy M Murphy
The in vitro and in vivo antimicrobial activities of dihydrofolate reductase (DHFR) inhibitors are inhibited in the presence of free thymidine in the growth milieu and in rodent efficacy models. However, for thymidine kinase (TK) deficient mutant bacteria, the presence of free thymidine does not impact the activity of DHFR inhibitors, and these mutants were used to assess the in vivo efficacy of the DHFR inhibitor, iclaprim. The efficacies of iclaprim, trimethoprim, and vancomycin were evaluated in a systemic mouse infection model...
November 27, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Ângela Novais, Ana R Freitas, Carla Rodrigues, Luísa Peixe
The need to identify highly related bacterial strains is ancient in clinical, industrial, or environmental microbiology. Strategies based on different phenotypic and genotypic principles have been used since the early 1930s with variable outcomes and performances, accompanying the evolution of bacterial features' knowledge as well as technologies, instruments, and data analysis tools. Today, more than ever, the implementation of bacterial typing methods that combine a high reliability and accuracy with a rapid, low-cost, and user-friendly performance is highly desirable, especially for clinical microbiology...
November 27, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Marlot C Kallen, S Natsch, B C Opmeer, M E J L Hulscher, J A Schouten, J M Prins, Paul van der Linden
A cornerstone of antimicrobial stewardship programs (ASPs) is monitoring quantitative antibiotic use. Frequently used metrics are defined daily dose (DDD) and days of therapy (DOT). The purpose of this study was (1) to explore for the hospital setting the possibilities of quantitative data retrieval on the level of medical specialty and (2) to describe factors affecting the usability and interpretation of these quantitative metrics. We performed a retrospective observational study, measuring overall systemic antibiotic use at specialty level over a 1-year period, from December 1st 2014 to December 1st 2015, in one university and 13 non-university hospitals in the Netherlands...
November 26, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Dorota Samojłowicz, Joanna Twarowska-Małczyńska, Aleksandra Borowska-Solonynko, Łukasz A Poniatowski, Nipika Sharma, Mieszko Olczak
Toxoplasmosis was linked to impairment in brain function, encompassing a wide range of behavioral and neuropsychiatric changes. Currently, the precise localization of Toxoplasma gondii in the human brain is limited and the parasite DNA was not found in population-based screening of autopsy cases. The aim of proposed study was to identify the presence of parasite DNA within the brain and its association with risky behavior and alcohol consumption in postmortem examination. Preliminarily, 102 cases with certain circumstances of death at time of forensic autopsy was included...
November 23, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Cha Han, Huiyang Li, Lulu Han, Chen Wang, Ye Yan, Wenhui Qi, Aiping Fan, Yingmei Wang, Fengxia Xue
The purpose of this study was to investigate the risk factors and pregnancy outcomes for aerobic vaginitis (AV) in late pregnancy. A total of 624 pregnant women who were treated in the perinatal unit at Tianjin Medical University General Hospital and 365 nonpregnant women who were evaluated at a health management center from January 2015 to June 2016 were recruited for this case-control study. A questionnaire covering personal hygiene habits and sociodemographic factors was administered to pregnant women to analyze risk factors for AV...
November 22, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Shu-Man Lin, Chih-Yung Wang, Ying-Yu Chen, Jen-Hung Wang, Chung-Chao Liang, Huei-Kai Huang
This study aimed to investigate the association between herpes zoster (HZ) and the risks of osteoporosis and fracture. We conducted a nationwide retrospective cohort study using the National Health Insurance Research Database of Taiwan. The study enrolled 63,786 patients: 31,893 diagnosed with HZ between 2000 and 2012 were included in the HZ cohort, and 31,893 matched controls without HZ were included in the non-HZ cohort, with 1:1 exact matching for age, sex, and index year. Hazard ratios (HRs) were calculated for the risks of osteoporosis and fracture according to the HZ status using the Cox proportional hazards regression models...
November 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Macarena Garrido-Estepa, P Latasa, G Y Ordóñez-León, M Martínez-Avilés, A de la Torre, L García-Comas
This study reviews non-typhoid Salmonella (NTS)-related hospitalisations at National level in Spain between 2010 and 2015. NTS hospitalisations were obtained from the National Registry of Hospitalisations. A descriptive analysis of the hospitalisations was performed, including hospitalisation rates (HR) and case-fatality rates (CFR%) calculation. For those with NTS as Main Diagnosis logistic regression were used to estimate the relationship between the different factors and death outcome. 21,660 registered NTS-related hospitalisations were described (88...
November 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Jesus Alberto Cardenas-de la Garza, Estephania De la Cruz-Valadez, Jorge Ocampo-Candiani, Oliverio Welsh
Lyme disease (borreliosis) is one of the most common vector-borne diseases worldwide. Its incidence and geographic expansion has been steadily increasing in the last decades. Lyme disease is caused by Borrelia burgdorferi sensu lato, a heterogeneous group of which three genospecies have been systematically associated to Lyme disease: B. burgdorferi sensu stricto Borrelia afzelii and Borrelia garinii. Geographical distribution and clinical manifestations vary according to the species involved. Lyme disease clinical manifestations may be divided into three stages...
November 19, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Christopher Greissl, Ahmad Saleh, Axel Hamprecht
The rapid detection of carbapenemase-producing Gram-negative bacteria is indispensable to optimize treatment and avoid the further spread of these organisms. While phenotypic tests are time-consuming and PCR is expensive and not available in many routine laboratories, immunochromatographic tests (ICT) can provide rapid results at moderate cost. The aim of this study was to determine the performance of the new ICT RESIST-4 O.K.N.V. K-SeT (Coris BioConcept, Gembloux, Belgium) which can detect the four most prevalent carbapenemases: OXA-48-like, KPC, NDM, and VIM...
November 17, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Jesús Troya, Pablo Ryan, Rocío Montejano, Alfonso Cabello, Guillermo Cuevas, Mariano Matarranz, Irene Cañamares, Javier Solís, Luis Álvarez-Sala Walther
Clinicians sometimes use switching strategies based on regimens such as RAL + ABC/3TC or RPV + ABC/3TC in order to resolve tolerability or safety issues associated with conventional recommended first-line strategies. Despite the low genetic barrier of these regimens, high safety and efficacy rates have been reported in retrospective studies.
November 15, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Radka Ivanova-Georgieva, Josefa Ruiz-Morales, Emilio García-Cabrera, María Victoria García-López, Juan Gálvez-Acebal, Antonio Plata-Ciezar, Javier de la Torre Lima, Carmen Hidalgo-Tenorio, Francisco Javier Martínez-Marcos, David Vinuesa García, Rafael Luque, Arístides de Alarcón González
A comparative study of the behaviour of left-sided infective endocarditis (left-sided IE) due to Streptococcus agalactiae (GBS) with left-sided IE caused by Staphylococcus aureus (SA). A prospective, multicentre cohort study in eight public hospitals in Spain, from January 1984 to December 2015; comparative analysis and factors associated with mortality. In total, there were 1754 episodes of left-sided IE; 41 (2.3%) caused by GBS vs. 344 (19.6%) due to SA, definitive IE 39 vs. 324 cases, males, 25 vs. 213, respectively...
November 14, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Wouter van den Bijllaardt, Olav P van der Jagt, Marc Peijs, Marco Janssens, Anton G Buiting, Anne Q Reuwer
Despite low sensitivity, culture of periprosthetic tissue (PPT) specimens on agars and in broths has traditionally been used for the detection of causative microorganisms in patients suspected for prosthetic joint infection (PJI). The aim of this study was to evaluate the added diagnostic value of culturing PPT in blood culture bottles (BCB) over the conventional combination of standard agar and broth alone. This prospective cohort study was conducted over a 12-month period and included consecutive patients undergoing revision arthroplasty...
November 14, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Liang En Wee, Mangaikarasi Sundarajoo, Way-Fang Quah, Ahmad Farhati, Jie-Ying Huang, Ying-Ying Chua
Outpatient parenteral antibiotic therapy (OPAT) can facilitate early discharge; however, not all offered OPAT can accept. We assessed factors associated with acceptance of OPAT in a large Asian tertiary hospital cohort. From 2014 to 2017, we reviewed all referrals to Singapore General Hospital's (SGH) Outpatient Parenteral Antibiotic Therapy (OPAT) service. We compared differences in sociodemographic and clinical factors between patients who opted for OPAT and those who declined, using chi-square test for univariate analysis and logistic regression for multivariate analysis...
November 14, 2018: European Journal of Clinical Microbiology & Infectious Diseases
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