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European Journal of Clinical Microbiology & Infectious Diseases

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https://www.readbyqxmd.com/read/30327897/activity-of-anti-cr3-rp-polyclonal-antibody-against-biofilms-formed-by-candida-auris-a-multidrug-resistant-emerging-fungal-pathogen
#1
Jaroslava Dekkerová, Jose L Lopez-Ribot, Helena Bujdáková
Fungal biofilm has remained a serious medical problem that complicates treatment of mycoses. In particular, once biofilms are formed, they display high levels of resistance against most common antifungals. Candida auris is currently considered as a serious emerging fungal pathogen frequently exhibiting high levels of resistance to antifungals. Recent studies have confirmed that C. auris shares similarity with Candida albicans in regards to virulence-associated proteins involved in adherence and biofilm development...
October 16, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30327896/sti-with-mycoplasma-genitalium-more-common-than-chlamydia-trachomatis-in-patients-attending-youth-clinics-in-sweden
#2
Peter Nolskog, Erik Backhaus, Salmir Nasic, Helena Enroth
The prevalence of Chlamydia trachomatis in Sweden is well known, whereas the prevalence of Mycoplasma genitalium is less well documented. Youth clinics offer free contraception advice, sexually transmitted infection (STI) testing and/or contact tracing for the age group 15-25 years. The main objective of this study was to determine the prevalence of STIs, the presence of symptoms and the role of contact tracing. From July 2013 to March 2014, 1001 persons, 509 women and 492 men, were included in this study of six youth clinics in the Region of Västra Götaland...
October 16, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30324540/factors-associated-with-unfavorable-outcome-in-a-multicenter-audit-of-100-infective-endocarditis
#3
David Chirio, Marion Le Marechal, Pamela Moceri, Arnaud de la Chapelle, Sylvie Chaillou-Optiz, Anaïs Mothes, Cédric Foucault, Laurence Maulin, Chirine Parsaï, Pierre-Marie Roger, Elisa Demonchy
We aimed to identify factors associated with unfavorable outcome in patients treated for infective endocarditis (IE), with a focus on departure from European guidelines. We conducted a retrospective audit of all adult patients treated for endocarditis during a 1-year period across a regional network of nine care centers in the south-east of France. Medical records were reviewed regarding patient and infection characteristics, antibiotic therapy, outcome, and compliance to the European Society of Cardiology guidelines...
October 15, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30298219/herpes-zoster-infection-and-statins-which-implications-in-clinical-practice
#4
Marco Zuin, Gianluca Rigatelli, Roberto L'Erario, Giovanni Zuliani, Claudio Bilato, Loris Roncon
Herpes zoster (HZ), which is caused by reactivation of latent varicella zoster virus (VZV), constitutes a major public health concern in both short- and long-term periods. Over the last years, several epidemiological studies have demonstrated that statin use is associated with increased risk of HZ at cerebral level. Because statins are among the most popular and best-selling drugs in western countries, this potential negative pleiotropic effect could have important implications in the daily clinical practice...
October 8, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30293204/role-of-prolonged-blood-culture-incubation-in-infective-endocarditis-diagnosis
#5
LETTER
Madiha Fida, Brenda L Dylla, M Rizwan Sohail, Bobbi S Pritt, Audrey N Schuetz, Robin Patel
No abstract text is available yet for this article.
October 6, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30291466/the-downside-of-antimicrobial-agents-for-wound-healing
#6
REVIEW
Apirujee Punjataewakupt, Supamas Napavichayanun, Pornanong Aramwit
The use of topical antimicrobials is beneficial for infection control in wound care because wound infection is the major cause of delayed healing. The advantages of topical over systemic antimicrobials include a higher concentration at the target site, fewer systemic adverse effects, and a lower incidence of antimicrobial resistance. Nowadays, topical antimicrobials are divided into three groups: disinfectants, antiseptics, and antibiotics. Only antiseptics and antibiotics can be applied to living skin; therefore, this review will focus only on these groups...
October 5, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30284179/the-association-between-treatment-appropriateness-according-to-eucast-and-clsi-breakpoints-and-mortality-among-patients-with-candidemia-a-retrospective-observational-study
#7
Nesrin Ghanem-Zoubi, Danny Zorbavel, Johad Khoury, Yuval Geffen, Majd Qasum, Svetlana Predescu, Mical Paul
To evaluate the association between appropriate antifungal treatment and mortality among patients with candidemia using different breakpoint definitions. In a retrospective study, we included all adults with candidemia in a tertiary center between 2009 and 2015. We defined three versions of appropriate (covering) antifungal treatment, according to Clinical and Laboratory Standards Institute (CLSI) 2008, CLSI 2012, and European Committee on Antimicrobial Susceptibility Testing (EUCAST) (2017 update) breakpoints...
October 3, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30276584/sensitive-and-specific-assay-for-the-simultaneous-detection-of-mycoplasma-genitalium-and-macrolide-resistance-associated-mutations
#8
Joyce F Braam, Sebastian van Marm, Tim T Severs, Yevgeniy Belousov, Walt Mahoney, Johannes G Kusters
Patients infected by Mycoplasma genitalium are often treated empirically with the macrolide azithromycin. Macrolide resistance is becoming quite common; empirical treatment is compromised. Sequencing was initially used to detected azithromycin resistance-associated mutations. As this was laborious, qPCRs have been developed for their detection. In the present study, we describe a fast, sensitive, and specific qPCR assay that enables routine testing of M. genitalium and macrolide resistance-associated mutations in a single assay...
October 1, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30269181/inoculum-effect-of-methicillin-susceptible-staphylococcus-aureus-against-broad-spectrum-beta-lactam-antibiotics
#9
Kyoung-Ho Song, Sook-In Jung, Shinwon Lee, Sohee Park, Eu Suk Kim, Kyung-Hwa Park, Wan Beom Park, Pyoeng Gyun Choe, Young Keun Kim, Yee Gyung Kwak, Yeon-Sook Kim, Hee-Chang Jang, Sungmin Kiem, Hye-In Kim, Hong Bin Kim
Scarce information concerning the inoculum effect (InE) of methicillin-susceptible Staphylococcus aureus (MSSA) against broad-spectrum β-lactam antibiotics is available. We investigated the InE of MSSA against ceftriaxone, cefepime, meropenem, ampicillin/sulbactam and piperacillin/tazobactam. The bacteraemic MSSA isolates were collected at ten Korean general hospitals from Sep 2013 to Mar 2015. The InE was defined if MICs of antibiotics at high inoculum (HI, ~5 × 107  CFU/ml) increased beyond the susceptible range compared to those at standard inoculum (SI, ~5 × 105  CFU/ml)...
September 30, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30269180/impact-of-total-laboratory-automation-on-workflow-and-specimen-processing-time-for-culture-of-urine-specimens
#10
Melanie L Yarbrough, William Lainhart, Allison R McMullen, Neil W Anderson, Carey-Ann D Burnham
Total laboratory automation (TLA) has the potential to reduce specimen processing time, improve standardization of cultures, and decrease turnaround time (TAT). The objective of this study was to perform a detailed interrogation of the impact of TLA implementation in all aspects of the workflow for routine culture of urine specimens. Using a detailed motion capture study, the time required for major steps of processing and result reporting were prospectively assessed for urine samples prior to (n = 215) and after (n = 203) implementation of the BD Kiestra TLA system...
September 29, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30267170/from-dengue-to-zika-the-wide-spread-of-mosquito-borne-arboviruses
#11
REVIEW
Shivani Sukhralia, Mansi Verma, Shruthi Gopirajan, P S Dhanaraj, Rup Lal, Neeti Mehla, Chhaya Ravi Kant
The worldwide invasion of arthropod-borne viruses (arboviruses) in recent decades is responsible for emerging public health threats. Some factors like climate change, urbanisation and uncontrolled population growth are fuelling their widespread. Arboviruses incorporate a vast collection of genetically diverse viral pathogens including that of dengue, Zika and chikungunya. These viruses are peculiar as they are zoonotic and are a serious harm to the society, with no particular therapy to neutralise their effect...
September 28, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30267169/implications-of-stx-loss-for-clinical-diagnostics-of-shiga-toxin-producing-escherichia-coli
#12
Thulasika Senthakumaran, Lin Torstensen Brandal, Bjørn-Arne Lindstedt, Silje Bakken Jørgensen, Colin Charnock, Hege Smith Tunsjø
The dynamics related to the loss of stx genes from Shiga toxin-producing Escherichia coli remain unclear. Current diagnostic procedures have shortcomings in the detection and identification of STEC. This is partly owing to the fact that stx genes may be lost during an infection or in the laboratory. The aim of the present study was to provide new insight into in vivo and in vitro stx loss in order to improve diagnostic procedures. Results from the study support the theory that loss of stx is a strain-related phenomenon and not induced by patient factors...
September 28, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30264355/matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-maldi-tof-ms-proteomic-profiling-of-cerebrospinal-fluid-in-the-diagnosis-of-enteroviral-meningitis-a-proof-of-principle-study
#13
Ignacio Torres, Estela Giménez, Víctor Vinuesa, Tania Pascual, Juan Miguel Moya, Juan Alberola, Ana Martínez-Sapiña, David Navarro
The use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) for diagnosing viral infections by directly testing clinical specimens has not previously been explored. In this proof-of-principle study, we tested the hypothesis that proteomic profiling of cerebrospinal fluid (CSF) by mass spectrometry may be useful in the diagnosis of enteroviral (EV) meningitis. A total of 114 cryopreserved CSF samples were analyzed, of which 47 were positive for EV and 67 were negative...
September 27, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30259214/multiplex-real-time-pcr-for-diagnosing-malaria-in-a-non-endemic-setting-a-prospective-comparison-to-conventional-methods
#14
R H T Nijhuis, L van Lieshout, J J Verweij, E C J Claas, E Wessels
Almost a decade ago our diagnostic laboratory implemented an in-house real-time PCR for the detection of Plasmodium DNA to diagnose malaria in parallel with conventional diagnostics, i.e., microscopy (thick and thin smears), quantitative buffy coat microscopy (QBC), and a rapid diagnostic test (RDT). Here we report our experiences and make a comparison between the different diagnostic procedures used in this non-endemic setting. All patients during the period February 2009-December 2017 suspected of malaria were prospectively tested at the moment of sample collection...
September 26, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30255431/how-are-trainees-in-clinical-microbiology-and-infectious-diseases-supervised-in-europe-an-international-cross-sectional-questionnaire-survey-by-the-trainee-association-of-escmid
#15
Zaira R Palacios-Baena, Thea Christine Zapf, David S Y Ong, Alberto E Maraolo, Caroline Rönnberg, Cansu Çimen, Céline Pulcini, Jesús Rodríguez-Baño, Maurizio Sanguinetti
The purpose of this study was to map the supervision of European trainees in clinical microbiology and infectious diseases during their training. An international cross-sectional questionnaire survey of 38 questions was distributed among trainees and recently graduated medical specialists from European countries. Descriptive analyses were performed on both the total group of respondents and regionally. In total, 393 respondents from 37 different countries were included. The median of overall satisfaction with the supervisor was 4 (interquartile range 3-4) on a Likert scale (range 1, not satisfied at all-5, completely satisfied)...
September 25, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30255430/real-time-quantitative-pcr-analysis-of-endoscopic-biopsies-for-diagnosing-cmv-gastrointestinal-disease-in-non-hiv-immunocompromised-patients-a-diagnostic-accuracy-study
#16
Yasuhiro Tsuchido, Miki Nagao, Minoru Matsuura, Satoshi Nakano, Masaki Yamamoto, Yasufumi Matsumura, Hiroshi Seno, Satoshi Ichiyama
Cytomegalovirus gastrointestinal diseases (CMV-GIDs) are end-organ diseases of the gastrointestinal (GI) tract caused by CMV in immunocompromised patients. We aimed to evaluate the performance of quantitative polymerase chain reaction (qPCR) on endoscopic biopsies. We retrospectively reviewed the qPCR data on endoscopic biopsies in nonhuman immunodeficiency virus (HIV) immunocompromised patients between January 2009 and May 2015. The performance of the qPCR for CMV-GID was evaluated with the sensitivity, specificity, and area under the receiver operating characteristic curve (AUROC)...
September 25, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30255429/update-on-laboratory-diagnosis-of-amoebiasis
#17
REVIEW
Syazwan Saidin, Nurulhasanah Othman, Rahmah Noordin
Amoebiasis, an enteric protozoan disease caused by Entamoeba histolytica, is a public health problem in many developing countries, causing up to 100,000 fatal cases annually. Detection of the pathogenic E. histolytica and its differentiation from the non-pathogenic Entamoeba spp. play a crucial role in the clinical management of patients. Laboratory diagnosis of intestinal amoebiasis in developing countries still relies on labour-intensive and insensitive methods involving staining of stool sample and microscopy...
September 25, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30246218/respiratory-syncytial-virus-associated-hospitalization-rates-in-high-risk-populations-an-observational-comparative-cohort-analysis
#18
LETTER
B Resch, C Puchas, B Urlesberger
No abstract text is available yet for this article.
September 24, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30244363/vaginal-ureaplasma-species-increase-chorioamnionitis-in-very-preterm-infants-with-preterm-premature-rupture-of-the-membranes-at-28-weeks-of-gestation
#19
Yu Suzuki, Kenji Horie, Yukari Yada, Yumi Kono, Chikako Hirashima, Rie Usui, Shigeki Matsubara, Akihide Ohkuchi
Our aim was to investigate the association between vaginal Ureaplasma species (spp.) and the subsequent occurrence of chorioamnionitis (CAM), perinatal death, neonatal morbidity, and long-term neurodevelopmental impairments (NDIs) at 3 years of age. We analyzed 55 pregnant women with singleton pregnancy who had preterm premature rupture of the membranes (pPROM) at < 28+0  weeks of gestation, and delivered between 22+0 and 31+6 weeks at our tertiary hospital in 2007-2016. NDIs were defined as either cerebral palsy or developmental delay evaluated at 1...
September 22, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30242543/fecal-calprotectin-concentrations-in-cancer-patients-with-clostridium-difficile-infection
#20
Taojun He, Samuel E Kaplan, Luz A Gomez, Xuedong Lu, Lakshmi V Ramanathan, Mini Kamboj, Yi-Wei Tang
Fecal calprotectin (fCPT) has been used as a surrogate marker for assessment of intestinal inflammation. We explore the utility of fCPT values as a diagnostic aid in cancer patients with suspected Clostridium difficile infection (CDI). A total of 232 stool specimens submitted for GeneXpert C. difficile PCR testing were included in the study. All specimens were tested for fCPT and toxin/GDH antigens. Clinical severity of CDI cases was determined by the IDSA/SHEA criteria. Significant differences of median fCPT values between CDI (n = 117, Median 183...
September 21, 2018: European Journal of Clinical Microbiology & Infectious Diseases
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