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Schizophrenia Research

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https://www.readbyqxmd.com/read/27908584/recurrent-urinary-tract-infections-in-psychotic-mood-disorders
#1
LETTER
Nina J Paletta, Alexandre K Wang, Brian J Miller
No abstract text is available yet for this article.
November 28, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27903412/long-term-employment-among-people-at-ultra-high-risk-for-psychosis
#2
Jack Cotter, Ashleigh Lin, Richard J Drake, Andrew Thompson, Barnaby Nelson, Patrick McGorry, Stephen J Wood, Alison R Yung
BACKGROUND: Psychotic disorders are associated with high rates of sustained unemployment, however, little is known about the long-term employment outcome of people at ultra-high risk (UHR) of developing psychosis. We sought to investigate the long-term unemployment rate and baseline predictors of employment status at follow-up in a large UHR cohort. METHOD: 268 UHR patients recruited from the Personal Assessment and Crisis Evaluation clinic in Melbourne, Australia were followed-up over 2-14years after initial presentation to the service...
November 27, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27894822/a-parallel-group-randomised-open-blinded-evaluation-of-acceptance-and-commitment-therapy-for-depression-after-psychosis-pilot-trial-outcomes-adapt
#3
Andrew Gumley, Ross White, Andy Briggs, Ian Ford, Sarah Barry, Corinna Stewart, Sara Beedie, Jacqueline McTaggart, Caoimhe Clarke, Rachel MacLeod, Emma Lidstone, Bruno Salgado Riveros, Robin Young, Hamish McLeod
BACKGROUND: Depression is one of the major contributors to poorer quality of life amongst individuals with psychosis and schizophrenia. The study was designed as a Pilot Trial to determine the parameters of a larger, definitive pragmatic multi-centre randomised controlled trial of Acceptance and Commitment Therapy for depression after psychosis (ACTdp) for individuals with a diagnosis of schizophrenia who also meet diagnostic criteria for major depression. METHODS: Participants were required to meet criteria for schizophrenia and major depression...
November 25, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27894821/schizophrenia-in-mid-adulthood-after-prenatal-exposure-to-the-chinese-famine-of-1959-1961
#4
Cuntong Wang, Yudong Zhang
Analyzing data from a large-scale, nationally representative sample, this study examines the association between prenatal exposure to the Chinese Famine (1959-1961) and schizophrenia risk in mid-adulthood and its urban/rural-specific and gender-specific patterns. The results showed that the cohort conceived and born during the famine had a higher risk of schizophrenia in mid-adulthood than cohorts conceived and born before or after the famine. In addition, schizophrenia risk was higher for urban residents than for rural residents and higher for females than for males...
November 25, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27890401/corrigendum-to-increased-diffusivity-in-gray-matter-in-recent-onset-schizophrenia-is-associated-with-clinical-symptoms-and-social-cognition-schizophr-res-176-2-3-oct-2016-144-150
#5
Jung Sun Lee, Chang-Yoon Kim, Yeon Ho Joo, Dominick Newell, Sylvain Bouix, Martha E Shenton, Marek Kubicki
No abstract text is available yet for this article.
November 25, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27889385/recurrent-urinary-tract-infections-in-children-and-adolescents-with-acute-psychosis
#6
LETTER
Jocelyn K Bayliss, Ketan Bodarya, Chelsea M Carson, Brian J Miller
No abstract text is available yet for this article.
November 23, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27889384/reduced-superoxide-dismutase-1-sod1-in-cerebrospinal-fluid-of-patients-with-early-psychosis-in-association-with-clinical-features
#7
Jennifer M Coughlin, Lindsay N Hayes, Teppei Tanaka, Meifang Xiao, Robert H Yolken, Paul Worley, F Markus Leweke, Akira Sawa
Oxidative stress is implicated in the underlying pathophysiology of psychosis from studies of animal models and of tissues obtained from patients. Superoxide dismutase 1 (SOD1) is an antioxidant responsible for reducing free radicals. SOD1 levels in cerebrospinal fluid (CSF) reportedly correlate with those in brain. We hypothesized that patients in early-stages of psychotic disease may have altered SOD1 in CSF compared to healthy controls. We previously reported in a pilot study that SOD1 levels in CSF of patients with recent onset schizophrenia (SZ) were lower compared to healthy controls...
November 23, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27889383/a-systematic-review-examining-factors-predicting-favourable-outcome-in-cognitive-behavioural-interventions-for-psychosis
#8
REVIEW
J O'Keeffe, R Conway, B McGuire
Psychosis is a debilitating mental health condition affecting approximately 4 persons per 1000. Cognitive behavioural therapy for psychosis (CBTp) has been shown to be an effective treatment for psychosis and is recommended by several national guidelines. CBTp does not work equally well with everyone, however, with some 50% of clients receiving little benefit. This review sets out to systematically assess the literature and methodological quality of a number of studies, which examine factors predicting successful outcome in CBTp...
November 23, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27889382/rare-and-common-variants-at-16p11-2-are-associated-with-schizophrenia
#9
Hong Chang, Lingyi Li, Ming Li, Xiao Xiao
Recent studies suggest that both common and rare variants are involved in the genetic risk of schizophrenia. Using a Cochran-Mantel-Haenszel (CMH) adjusted meta-analysis in 36,676 schizophrenia patients and 48,331 healthy controls from 24 independent samples, we identify the microduplications at 16p11.2 locus (29.6-30.2Mb, hg19) to be strongly associated with the illness (P value<2.2×10(-16), CHM-adjusted OR=10.79). The frequency of this microduplication is significantly higher in schizophrenia patients (0...
November 23, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27887780/insight-and-white-matter-fractional-anisotropy-in-first-episode-schizophrenia
#10
Laila Asmal, Stefan du Plessis, Matthijs Vink, Jean-Paul Fouche, Bonginkosi Chiliza, Robin Emsley
Impaired insight is a hallmark feature of schizophrenia. Structural studies implicate predominantly prefrontal, cingulate, cuneus/precuneus, and inferior temporal brain regions. The cortical midline structures (CMS) are also implicated in functional studies primarily through self-reflective processing tasks. However, few studies have explored the relationship between white matter tracts and insight in schizophrenia, and none in first-episode schizophrenia (FES). Here, we examined for fractional anisotropy (FA) differences in 89 minimally treated FES patients and 98 matched controls, and identified those FA differences associated with impaired clinical insight in patients...
November 23, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27887781/high-psychosis-liability-is-associated-with-altered-autonomic-balance-during-exposure-to-virtual-reality-social-stressors
#11
Jacqueline Counotte, Roos Pot-Kolder, Arie M van Roon, Olivier Hoskam, Mark van der Gaag, Wim Veling
BACKGROUND: Social stressors are associated with an increased risk of psychosis. Stress sensitisation is thought to be an underlying mechanism and may be reflected in an altered autonomic stress response. Using an experimental Virtual Reality design, the autonomic stress response to social stressors was examined in participants with different liability to psychosis. METHOD: Fifty-five patients with recent onset psychotic disorder, 20 patients at ultra-high risk for psychosis, 42 siblings of patients with psychosis and 53 controls were exposed to social stressors (crowdedness, ethnic minority status and hostility) in a Virtual Reality environment...
November 22, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27887779/challenges-facing-the-identification-of-distinctive-cognitive-and-neurobiological-features-of-schizophrenia-and-bipolar-disorder-and-the-need-for-a-data-driven-approach-response-to-dr-martino
#12
LETTER
https://www.readbyqxmd.com/read/27884434/relative-risks-of-cardiovascular-disease-in-people-prescribed-olanzapine-risperidone-and-quetiapine
#13
Dpj Osborn, L Marston, I Nazareth, M B King, I Petersen, K Walters
: Antipsychotics may confer long term benefits and risks, including cardiovascular disease (CVD) risk. Several studies using routine clinical data have reported associations between antipsychotics and CVD but potential confounding factors and unclear classification of drug exposure limits their interpretation. METHOD: We used data from The Health Improvement Network, a large UK primary care database to determine relative risks of (CVD) comparing similar groups of people only prescribed olanzapine versus either risperidone or quetiapine...
November 21, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27884433/social-cognition-in-schizophrenia-and-bipolar-disorder-just-quantitative-differences
#14
LETTER
Diego J Martino, Cecilia Samamé, Sergio A Strejilevich
No abstract text is available yet for this article.
November 21, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27881233/do-people-with-schizophrenia-experience-more-negative-emotion-and-less-positive-emotion-in-their-daily-lives-a-meta-analysis-of-experience-sampling-studies
#15
Hyein Cho, Rachel Gonzalez, Lindsey M Lavaysse, Sunny Pence, Daniel Fulford, David E Gard
Research on emotion experience in response to valenced stimuli has consistently shown that people with schizophrenia have the capacity to experience emotion. Specifically, people with schizophrenia report similar experiences to both positive and negative emotion-eliciting stimuli as individuals without the disorder. However, it is less clear if people with schizophrenia experience similar levels of positive emotion and negative emotion outside of standardized laboratory contexts, as in their daily lives. One reliable method for assessing emotion experience in schizophrenia has been the Experience Sampling Method (ESM), or Ecological Momentary Assessment (EMA)...
November 21, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27876273/the-macarthur-competence-assessment-tools-for-assessing-decision-making-capacity-in-schizophrenia-a-meta-analysis
#16
Shi-Bin Wang, Yuan-Yuan Wang, Gabor S Ungvari, Chee H Ng, Ren-Rong Wu, Jijun Wang, Yu-Tao Xiang
OBJECTIVE: This meta-analysis aimed to examine the decisional capacity measured by the MacArthur Competence Assessment Tools (MacCAT) in schizophrenia. METHOD: English (PubMed, PsycINFO, Embase, Cochrane Library databases and the Cochrane Controlled Trials Register) and Chinese (Wan Fang Database and Chinese National Knowledge Infrastructure) databases were systematically and independently searched from 1995 until August 1, 2016. Weighted and standardized mean differences were calculated...
November 18, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27866695/does-formulation-matter-a-systematic-review-and-meta-analysis-of-oral-versus-long-acting-antipsychotic-studies
#17
REVIEW
Giovanni Ostuzzi, Irene Bighelli, Ryuhei So, Toshi A Furukawa, Corrado Barbui
Recently, many authors highlighted the potential advantages of a broader prescription of long-acting injectable antipsychotics (LAIs) based on various assumptions, including favorable pharmacokinetic features. In this systematic review, data from randomized controlled trials comparing LAIs versus the oral formulation of the same antipsychotic were meta-analyzed in order to ascertain whether the route of administration may be associated with a different efficacy and tolerability profile. Of 21 included studies, 18 contributed to the meta-analysis, providing data for risperidone, olanzapine, aripiprazole, zuclopenthixol, fluphenazine and haloperidol...
November 17, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27863933/lifestyle-factors-may-be-linked-to-symptoms-of-metabolic-syndrome-in-people-at-risk-for-psychosis
#18
LETTER
Rebekah Carney, Tim Bradshaw, Joseph Firth, Jack Cotter, Alison R Yung
No abstract text is available yet for this article.
November 16, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27863935/association-of-sflt-1-and-worsening-psychopathology-in-relatives-at-high-risk-for-psychosis-a-longitudinal-study
#19
Paulo L Lizano, Jeffrey K Yao, Neeraj Tandon, Suraj Sarvode Mothi, Debra M Montrose, Matcheri S Keshavan
BACKGROUND: Angiogenic dysfunction and abnormalities in psychopathology and brain structure have been reported in schizophrenia, but their relationships are mostly unknown. We recently demonstrated that sFlt-1, anti-angiogenic factor, was significantly elevated in patients at familial high-risk for psychosis (FHR). We hypothesized that elevated sFlt-1 correlates with baseline and longitudinal changes in psychopathology, cognition, and brain structure. METHODS: Plasma sFlt-1 in FHR (n=35) and HC (n=39) was obtained at baseline...
November 15, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27863934/child-death-and-maternal-psychosis-like-experiences-in-44-low-and-middle-income-countries-the-role-of-depression
#20
Ai Koyanagi, Hans Oh, Josep Maria Haro, Fumi Hirayama, Jordan DeVylder
BACKGROUND: Studies on the effect of child death on the mental wellbeing of women in low- and middle-income countries (LMICs) are scarce despite the high child mortality rates. Thus, the aim of the current study was to assess the association between child death and psychosis-like experiences (PLEs), as well as the role of depression in this association. METHODS: Data from 44 LMICs which participated in the World Health Survey (WHS) were analyzed. A total of 59,444 women who ever gave birth, aged 18-49years, without a self-reported lifetime psychosis diagnosis, were included in the analysis...
November 15, 2016: Schizophrenia Research
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