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Schizophrenia Research

Menahem I Krakowski, Pal Czobor
OBJECTIVE: We delineated important trait predispositions to violence, including psychopathic and impulsive traits and trait aggression, in patients with schizophrenia and in the general population. METHOD: The study included 144 subjects: 40 violent (VS's) and 34 nonviolent (NV's) patients with schizophrenia, 35 healthy controls (HC's) and 35 non-psychotic violent subjects (NPV's). We used the Psychopathy Checklist, Buss-Perry Aggression Questionnaire, and Barratt Impulsiveness Scale (BIS-11)...
July 16, 2018: Schizophrenia Research
Keiichiro Nishida, Atsuhito Toyomaki, Yosuke Koshikawa, Hidehito Niimura, Tsubasa Morimoto, Masayuki Tani, Ken Inada, Taiga Ninomiya, Hikaru Hori, Jun Manabe, Asuka Katsuki, Takamitsu Kubo, Masanao Shirahama, Kentaro Kohno, Toshihiko Kinoshita, Ichiro Kusumi, Akira Iwanami, Takefumi Ueno, Toshifumi Kishimoto, Takeshi Terao, Kazuyuki Nakagome, Tomiki Sumiyoshi
No abstract text is available yet for this article.
July 13, 2018: Schizophrenia Research
Jared W Keeley, Wolfgang Gaebel, Michael B First, Destiny L Peterson, Tahilia Rebello, Pratap Sharan, Geoffrey M Reed
Classifications of psychotic disorders are moving towards utilizing dimensional symptom domains as the preferred mechanism for describing psychotic symptomatology. The ICD-11 has proposed six symptom domains (Positive symptoms, Negative symptoms, Depressive symptoms, Manic symptoms, Psychomotor symptoms, and Cognitive symptoms) that would be rated in addition to providing a psychotic disorder diagnosis. This study investigated clinicians' use of dichotomous versus multi-point scales for rating these six domains...
July 13, 2018: Schizophrenia Research
Merve Kasap, Vivek Rajani, Jackie Rajani, Donard S Dwyer
Schizophrenia is a devastating psychiatric illness that affects approximately 1% of the population. Genetic variation in multiple genes causes elevated risk for the disorder, but the molecular basis is inadequately understood and it is not clear how risk genes have evolved and persisted in the genome. To address these issues, we have identified orthologs/homologs of 344 schizophrenia risk genes (from the Psychiatric Genomics Consortium dataset) in lower organisms, including C. elegans, Drosophila and zebrafish, along with phenotypes produced by genetic disruption in C...
July 12, 2018: Schizophrenia Research
Kentaro Morita, Kenichiro Miura, Michiko Fujimoto, Emiko Shishido, Tomoko Shiino, Junichi Takahashi, Hidenaga Yamamori, Yuka Yasuda, Noriko Kudo, Yoji Hirano, Daisuke Koshiyama, Naohiro Okada, Manabu Ikeda, Toshiaki Onitsuka, Norio Ozaki, Kiyoto Kasai, Ryota Hashimoto
Eye movement abnormalities have been reported in schizophrenia; however, their influences on everyday life remain unknown. From data on 69 subjects with schizophrenia and 246 healthy subjects, we found positive correlations between eye movement measures and work hours, which were only significant in subjects with schizophrenia. This relationship was also confirmed in a multi-site dataset including 118 subjects with schizophrenia and 280 healthy subjects. These findings further strengthen our understanding of eye movement abnormalities and their relevance in clinical recovery...
July 12, 2018: Schizophrenia Research
Helen M Spencer, Martina McMenamin, Richard Emsley, Douglas Turkington, Graham Dunn, Anthony P Morrison, Alison Brabban, Paul Hutton, Robert Dudley
This study investigated the effect of "dose" and the components of Cognitive Behavioral Therapy (CBT) on treatment effects. It is a secondary analysis of the ACTION (Assessment of Cognitive Therapy Instead of Neuroleptics) trial which investigated CBT for people with schizophrenia spectrum disorders that chose not to take antipsychotic medication. Using instrumental variable methods, we found a "dose-response" such that each CBT session attended, reduced the primary outcome measure (the PANSS total score) by approximately 0...
July 12, 2018: Schizophrenia Research
Sinead M O'Donovan, Ana Franco-Villanueva, Valentina Ghisays, Jody L Caldwell, Vahraim Haroutunian, Lisa M Privette Vinnedge, Robert E McCullumsmith, Matia B Solomon
DEK is a chromatin-remodeling phosphoprotein found in most human tissues, but its expression and function in the human brain is largely unknown. DEK depletion in vitro induces cellular and molecular anomalies associated with cognitive impairment, including down-regulation of the canonical Wnt/β-catenin signaling pathway. ToppGene analyses link DEK loss to genes associated with various dementias and age-related cognitive decline. To examine the role of DEK in cognitive impairment in severe mental illness, DEK protein expression was assayed by immunoblot in the anterior cingulate cortex (ACC) of subjects with schizophrenia...
July 12, 2018: Schizophrenia Research
Ingrid Hartveit Svendsen, Merete G Øie, Paul Møller, Barnaby Nelson, Ingrid Melle, Elisabeth Haug
BACKGROUND: Basic self-disturbances (BSDs) are considered core features of schizophrenia spectrum disorders, and are present in the prodromal, early psychotic and chronic phases. Considerable levels of BSDs are also present at first treatment in some patients with psychotic disorders outside the schizophrenia spectrum. There is limited knowledge about the stability of self-disturbances over time. AIM: To explore the stability of BSDs in a seven-year follow-up of first treatment patients, and the association between baseline levels and changes in BSDs and diagnostic changes at follow-up...
July 11, 2018: Schizophrenia Research
Sunny X Tang, Paul J Moberg, James J Yi, Andrew S Wiemken, Erich M Dress, Tyler M Moore, Monica E Calkins, Donna M McDonald-McGinn, Elaine H Zackai, Beverly S Emanuel, Ruben C Gur, Raquel E Gur, Bruce I Turetsky
Olfactory functioning is a promising biomarker for psychosis in 22q11.2 deletion syndrome (22q11DS) but has not been well studied to date. This is a pilot effort to evaluate the potential for tests of olfactory functioning to contribute to risk and resilience prediction in 22q11DS, and is the first study to evaluate relationships among olfactory deficits, cognition and psychosis-spectrum symptoms. Odor identification and discrimination were evaluated in 32 individuals with 22q11DS and 110 healthy comparison subjects (HC)...
July 11, 2018: Schizophrenia Research
René Ernst Nielsen, Kristian Bjørn Hessellund, Jan Brink Valentin, Rasmus W Licht
OBJECTIVE: Investigate the associations of long-acting injectable (LAI) second generation antipsychotic drugs with number of relapses, psychiatric admissions, days hospitalized, intentional self-harm events, and costs linked to hospitalizations in incident patients diagnosed with schizophrenia. METHOD: A nationwide, population-based, retrospective study utilizing mirror-image models before and after initiation of LAI SGA. RESULTS: 10,509 patients were included as study population, with analyses being conducted on 2223 patients in a six-month period, 1383 in a 12-month period, 713 in a 24-month period...
July 10, 2018: Schizophrenia Research
Andrew Moskowitz
No abstract text is available yet for this article.
July 10, 2018: Schizophrenia Research
Philip Watson, Jian-Ping Zhang, Asra Rizvi, Jonathan Tamaiev, Michael L Birnbaum, John Kane
OBJECTIVE: Improving quality of life for people with first episode psychosis is an important aspect of recovery. Our objective was to review the associative factors on quality of life in first episode psychosis. A meta-analysis was conducted on the associations between quality of life, symptom severity, and duration of untreated psychosis. METHOD: Fifty-one articles were identified (published through 08/29/2016) that provided data on the relationship between quality of life and at least one other outcome measure of interest in first episode psychosis...
July 10, 2018: Schizophrenia Research
Daisuke Koshiyama, Masaki Fukunaga, Naohiro Okada, Kentaro Morita, Kiyotaka Nemoto, Fumio Yamashita, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Sinead Kelly, Neda Jahanshad, Noriko Kudo, Hirotsugu Azechi, Yoshiyuki Watanabe, Gary Donohoe, Paul M Thompson, Kiyoto Kasai, Ryota Hashimoto
Patients with schizophrenia show severe impairment in social function and have difficulty in their daily social life. Although a recent large-scale multicenter study revealed alterations in white matter microstructures, the association between these anatomical changes and social dysfunction in schizophrenia remains unknown. Therefore, we investigated the association between the white matter integrity of regions of interest and social function in schizophrenia. A total of 149 patients with schizophrenia and 602 healthy comparison subjects (HCS) underwent DTI and completed the Picture Arrangement subtest of the Wechsler Adult Intelligence Scale-Third Edition and the Finance subscale of the University of California, San Diego, Performance-Based Skills Assessment Brief, as social indices of interest...
July 10, 2018: Schizophrenia Research
Esther Hanssen, Anne-Kathrin Fett, Thomas P White, Caroline Caddy, Stian Reimers, Sukhi S Shergill
Patients with schizophrenia show reduced cooperation and less sensitivity to social cues in pairwise interactions, however, it remains unclear whether these mechanisms are also present in interactions within social groups. We used a public goods game to investigate cooperation and sensitivity to social feedback in group interactions in 27 patients with schizophrenia and 27 healthy controls. Participants played 40 trials in two conditions: 1) no fine (20 trials): participants had the choice of investing into the public good (i...
July 10, 2018: Schizophrenia Research
Patrizia Russo, Giulia Prinzi, Stefania Proietti, Palma Lamonaca, Alessandra Frustaci, Stefania Boccia, Rosarita Amore, Maria Lorenzi, Graziano Onder, Emanuele Marzetti, Vanessa Valdiglesias, Fiorella Guadagni, Maria Giovanna Valente, Gerland Lo Cascio, Sara Fraietta, Giuseppe Ducci, Stefano Bonassi
Schizophrenia is a severe, chronic mental disorder. Schizophrenia is visualized as an accelerated cellular aging syndrome characterized by early onset of cardiovascular disease causing premature mortality. In human aging involves alterations in telomere length (TL). To investigate the presence of TL shortening in schizophrenia and psychiatric syndromes associated, this condition was studied in leukocytes (LTL) of a sample of patients suffering from schizophrenia and other psychotic disorders, and compared with a group of non-psychiatric controls...
July 9, 2018: Schizophrenia Research
Ilanit Hasson-Ohayon, Gil Goldzweig, Adi Lavi-Rotenberg, Lauren Luther, Paul H Lysaker
Schizophrenia involves a range of interrelated impairments in functioning due to symptoms and deficits in varying domains of cognition including neurocognition, social cognition and metacognition. Yet little is known whether certain symptoms or cognitive impairments play a more central role than others. To explore, we conducted a network analysis of five types of symptoms, six domains of neurocognition and multiple aspects of both social cognition and metacognition. Participants were 81 adults with a schizophrenia spectrum disorder in a non-acute phase of the disorder...
July 9, 2018: Schizophrenia Research
Ying Li, Wen-Xiu Li, Ying-Min Zou, Zhuo-Ya Yang, Dong-Jie Xie, Yin Yang, Simon S Y Lui, Gregory P Strauss, Eric F C Cheung, Raymond C K Chan
OBJECTIVE: The present study aimed to validate a severity cut-off of negative symptoms for persistent negative symptoms (PNS) identification using the Clinical Assessment Interview for Negative Symptoms (CAINS). METHOD: A total of 206 patients with schizophrenia were recruited and divided into the PNS group (n = 57) and the Non-PNS group (n = 149) using PNS criteria based on the SANS and the SAPS. To determine the appropriate cut-offs on the CAINS in identifying PNS, Receiver Operating Characteristic (ROC) curve analysis was conducted in the PNS and Non-PNS groups...
July 8, 2018: Schizophrenia Research
Clementine J Edwards, Matteo Cella, Richard Emsley, Nicholas Tarrier, Til H M Wykes
BACKGROUND: It has been hypothesised that a reduction in anticipatory pleasure contributes to reduced levels of functioning in people with schizophrenia. Previous research on anticipatory pleasure, however, reports mixed findings and has not yet examined the link between anticipatory pleasure and activity. The aim of this study is to examine how pleasure anticipation is related to difficulties engaging in activity in people with schizophrenia. METHOD: A healthy control group (n = 44) and a group of individuals with schizophrenia (n = 36) completed an experience sampling study using portable devices...
July 6, 2018: Schizophrenia Research
Cecilia Juan-Perez, Sarah Farrand, Dennis Velakoulis
BACKGROUND: Copy number variants have made important contributions to understanding neuropsychiatric disorders, including schizophrenia. Deletions in genes encoding neuronal cell adhesion molecules have identified widely varied neurodevelopmental phenotypes. CASE SUMMARY: A 27-year old woman presented with schizophrenia, borderline intellectual functioning and shortened metacarpal bones. Subsequent electroencephalogram confirmed genetic generalised epilepsy and microarray analysis found a 0...
July 5, 2018: Schizophrenia Research
Daniela Hubl, Frauke Schultze-Lutter, Martinus Hauf, Thomas Dierks, Andrea Federspiel, Michael Kaess, Chantal Michel, Benno G Schimmelmann, Jochen Kindler
BACKGROUND: Patients at clinical high risk (CHR) for psychosis exhibit increased striatal cerebral blood flow (CBF) during the resting state and impaired cognitive function. However, the relation between CBF and cognitive impairment is unknown. We therefore studied the association between striatal CBF and executive functioning and evaluated the functional connectivity (FC) between dorsal striatum and the frontal cortex in CHR. METHODS: In total, 47 participants [29 with CHR, 18 matched clinical controls (CC)] were assessed for ultra-high-risk criteria and basic symptoms and were tested for executive functioning using the trail making test-B (TMT-B)...
July 5, 2018: Schizophrenia Research
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