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Schizophrenia Research

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https://www.readbyqxmd.com/read/28811079/neuroleptic-free-youth-at-ultrahigh-risk-for-psychosis-evidence-diminished-emotion-reactivity-that-is-predicted-by-depression-and-anxiety
#1
June Gruber, Gregory P Strauss, Laure Dombrecht, Vijay A Mittal
Although abnormalities in emotional response have long been considered a core feature of the chronic phase of schizophrenia, few investigations have examined emotional response in individuals at ultrahigh-risk (UHR) for psychosis. We investigated whether neuroleptic-free UHR (n=29) and healthy control (n=32) participants differed in emotional reactivity and emotion regulation on a laboratory-based task that required reporting levels of positive and negative affect to pleasant, unpleasant, and neutral stimuli...
August 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28803848/disengagement-in-immigrant-groups-receiving-services-for-a-first-episode-of-psychosis
#2
Anika Maraj, Franz Veru, Laura Morrison, Ridha Joober, Ashok Malla, Srividya Iyer, Jai Shah
OBJECTIVE: Although early intervention (EI) programs for psychosis invest in clients remaining engaged in treatment, disengagement remains a concern. It is not entirely clear whether immigrants are likelier to disengage. The rates and predictors of disengagement for immigrant vis-à-vis non-immigrant clients in a Canadian EI setting were analyzed. METHOD: 297 clients were included in a time-to-event analysis with Cox Proportional Hazards regression models. Immigrant status (first- or second-generation immigrant or non-immigrant), age, gender, education, substance abuse, family contact, social and material deprivation and medication non-adherence were tested as predictors of service disengagement...
August 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28803847/psychotic-symptoms-influence-the-development-of-anterior-cingulate-bold-variability-in-22q11-2-deletion-syndrome
#3
Daniela Zöller, Maria Carmela Padula, Corrado Sandini, Maude Schneider, Elisa Scariati, Dimitri Van De Ville, Marie Schaer, Stephan Eliez
Chromosome 22q11.2 deletion syndrome (22q11DS) is a neurodevelopmental disorder associated with a broad phenotype of clinical, cognitive and psychiatric features. Due to the very high prevalence of schizophrenia (30-40%), the investigation of psychotic symptoms in the syndrome is promising to reveal biomarkers for the development of psychosis, also in the general population. Since schizophrenia is seen as a disorder of the dynamic interactions between brain networks, we here investigated brain dynamics, assessed by the variability of blood oxygenation level dependent (BOLD) signals, in patients with psychotic symptoms...
August 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28802820/attenuated-psychotic-symptoms-in-children-and-adolescent-offspring-of-patients-with-schizophrenia
#4
Ana Noguera, Josefina Castro-Fornieles, Soledad Romero, Elena de la Serna, Gisela Sugranyes, Vanessa Sánchez-Gistau, Dolores Moreno, Covadonga M Díaz-Caneja, Jessica Merchán-Naranjo, Cloe Llorente, Inmaculada Baeza
No abstract text is available yet for this article.
August 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28802819/increased-prevalence-of-toxoplasma-gondii-seropositivity-in-patients-with-treatment-resistant-schizophrenia
#5
LETTER
Suzana Vlatkovic, Marina Sagud, Dubravka Svob Strac, Mario Sviben, Maja Zivkovic, Maja Vilibic, Bjanka Vuksan-Cusa, Alma Mihaljevic-Peles, Nela Pivac
No abstract text is available yet for this article.
August 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28802818/schizophrenia-and-psychosis-does-changing-the-label-change-the-beliefs
#6
LETTER
L Magliano, M Petrillo, G Ruggiero, G Schioppa
No abstract text is available yet for this article.
August 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28801195/avoidance-of-accelerated-aging-in-schizophrenia-clinical-and-biological-characterization-of-an-exceptionally-high-functioning-individual
#7
Barton W Palmer, Raeanne C Moore, Lisa T Eyler, Luz L Pinto, Elyn R Saks, Dilip V Jeste
OBJECTIVE: To determine the clinical and biological characteristics of an exceptionally high functioning index person (IP) with schizophrenia in her mid-50s, which may represent compensatory mechanisms, and potentially, avoidance of the accelerated aging typically associated with schizophrenia. METHOD: IP, 11 other women with schizophrenia, and 11 non-psychiatric comparison (NC) women were assessed with standard ratings of psychopathology, neurocognitive function, decisional capacity, and functional brain imaging...
August 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28801194/medial-septum-modulates-hippocampal-gamma-activity-and-prepulse-inhibition-in-an-n-methyl-d-aspartate-receptor-antagonist-model-of-schizophrenia
#8
L Stan Leung, Jingyi Ma
We reviewed the participation of the septohippocampal system in an animal model of schizophrenia that was acutely induced by systemic injection of an N-methyl-d-aspartate (NMDA) receptor antagonist such as phencyclidine, MK-801 and ketamine. The NMDA receptor antagonist-induced model of schizophrenia is characterized by behavioral and electrophysiological disruptions, including a decrease in prepulse inhibition of the acoustic startle response (PPI), hyperlocomotion, decrease in gating of hippocampal auditory evoked potentials and robust increase in hippocampal gamma (30-100Hz) oscillations...
August 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28797527/impaired-theta-and-alpha-oscillations-underlying-stopsignal-response-inhibition-deficits-in-schizophrenia
#9
LETTER
Patrick S Cooper, Matthew E Hughes
No abstract text is available yet for this article.
August 7, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28797526/psychotic-experiences-and-disability-findings-from-the-collaborative-psychiatric-epidemiology-surveys
#10
Hans Oh, Ai Koyanagi, Ian Kelleher, Jordan DeVylder
Psychotic experiences are associated with a number of poor clinical outcomes, including multimorbid psychopathology, suicidal behavior, and poor treatment response. We wished to investigate the relationship between psychotic experiences and disability, including the following domains: cognition, mobility, self-care, social interaction, role functioning, and days out of role. We used three nationally representative and racially/ethnically diverse samples of the general US adult population: the National Comorbidity Survey Replication (NCS-R), the National Latino and Asian American Survey (NLAAS), and the National Survey of American Life (NSAL)...
August 7, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28797525/transglutaminase-5-related-schizophrenia
#11
LETTER
Peter Joe, Mara Getz, Samantha Redman, Thorsten Manfred Kranz, Moses V Chao, Shannon Delaney, Lea Ann Chen, Dolores Malaspina
No abstract text is available yet for this article.
August 7, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28789876/investigating-the-role-of-metastability-in-the-disturbed-brain-functional-connectivity-observed-under-the-experience-of-thought-blocks-in-schizophrenia
#12
LETTER
Elias Koutsoukos, Elias Angelopoulos
No abstract text is available yet for this article.
August 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28779853/preliminary-psychometric-properties-of-the-brief-negative-symptom-scale-in-youth-at-clinical-high-risk-for-psychosis
#13
Gregory P Strauss, Hannah C Chapman
Preliminary psychometric properties of an adapted version of the Brief Negative Symptom Scale (BNSS) are reported in youth at Clinical High-Risk for psychosis (CHR). Participants included 29 CHR youth who met criteria for a prodromal syndrome on the Structured Interview for Prodromal Syndromes (SIPS). The adapted BNSS demonstrated excellent internal consistency, convergent validity, and discriminant validity, suggesting that the BNSS has utility for assessing negative symptoms in a CHR population.
August 2, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28779852/negative-symptoms-and-the-formation-of-social-affiliative-bonds-in-schizophrenia
#14
Julie M McCarthy, Kristen R Bradshaw, Lauren T Catalano, Cristina P Garcia, Asia Malik, Melanie E Bennett, Jack J Blanchard
Negative symptoms in schizophrenia are characterized by deficits in normative experiences and expression of emotion, and they are associated with poor social functioning. Negative symptoms relating to deficits in motivation and pleasure may hinder the development of affiliative bonds. The current study used a novel procedure to examine the relation between negative symptoms and the development of social affiliation within a laboratory setting. Fifty-five men (35 controls; 20 with a schizophrenia spectrum disorder) completed three Social Affiliation Enhancement Tasks with an experimenter partner...
August 2, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28779851/a-tale-of-two-sites-differential-impairment-of-frequency-and-duration-mismatch-negativity-across-a-primarily-inpatient-versus-a-primarily-outpatient-site-in-schizophrenia
#15
Migyung Lee, Pejman Sehatpour, Elisa C Dias, Gail S Silipo, Joshua T Kantrowitz, Antigona M Martinez, Daniel C Javitt
Deficits in mismatch negativity (MMN) generation are among the best replicated neurophysiological deficits in schizophrenia, with reduced amplitude reflecting impaired information processing at the level of supratemporal auditory cortex. Differential patterns of MMN dysfunction according to deviant types have been reported across studies, with some research groups showing impairment in duration MMN but not frequency MMN, and other research groups reporting both findings. We evaluate the hypothesis that recruitment setting, reflecting current functional status, might be an important determinant of the pattern of MMN dysfunction...
August 2, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28779850/working-toward-changing-the-duration-of-untreated-psychosis-dup
#16
Vinod H Srihari
No abstract text is available yet for this article.
August 2, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28778554/comorbidity-of-chronic-somatic-diseases-in-patients-with-psychotic-disorders-and-their-influence-on-4-year-outcomes-of-integrated-care-treatment-access-ii-study
#17
Martin Lambert, Friederike Ruppelt, Anna-Katharina Siem, Anja Christine Rohenkohl, Vivien Kraft, Daniel Luedecke, Mary Sengutta, Romy Schröter, Anne Daubmann, Christoph U Correll, Jürgen Gallinat, Anne Karow, Klaus Wiedemann, Daniel Schöttle
BACKGROUND: People with psychotic disorders fulfilling criteria of a severe and persistent mental illness (SPMI) display a high risk of somatic comorbidity (SC). METHODS: ACCESS II is a prospective, long-term study examining the effectiveness of Integrated Care for people with psychotic disorders fulfilling SPMI criteria. Chronic comorbid somatic disorders were systematically assessed according to ICD-10-GM criteria. Patients treated for ≥4years in ACCESS were categorized as early psychosis (treatment: ≤2years) or non-early psychosis (treatment: >2years) patients...
August 1, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28778553/thought-language-and-communication-deficits-and-association-with-everyday-functional-outcomes-among-community-dwelling-middle-aged-and-older-adults-with-schizophrenia
#18
Anjana Muralidharan, Anastasia Finch, Christopher R Bowie, Philip D Harvey
Older adults with schizophrenia experience poorer community integration and social functioning compared to same-age peers with no mental health disorders; these individuals are at elevated risk for functional decline and early institutionalization in long-term care facilities. Deficits in thought, language, and communication (TLC; that is, thought disorder and alogia) are core features of schizophrenia and may worsen with age; however, little research focuses on the functional sequelae of these impairments among older adults with schizophrenia...
August 1, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28768602/completing-the-puzzle-the-search-for-pieces-in-the-understanding-of-psychosis-risk-in-22q11-2-deletion-syndrome
#19
Stephen R Hooper, Vandana Shashi
No abstract text is available yet for this article.
July 30, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28768601/translating-cognitive-behavioral-interventions-from-bench-to-bedside-the-feasibility-and-acceptability-of-cognitive-remediation-in-research-as-compared-to-clinical-settings
#20
Alice Medalia, Matthew D Erlich, Charlotte Soumet-Leman, Alice M Saperstein
Cognitive remediation (CR) research typically addresses internal validity, and few studies consider CR in a real-world context. This study evaluated the fit between the program conditions and treatment model in research and clinical settings, with the goal of informing future research on the contextual challenges associated with the implementation of CR. Data was drawn from an initiative by New York State's Office of Mental Health (OMH), to implement CR programs for adults with Serious Mental Illness (SMI) in 16 state operated outpatient clinics...
July 30, 2017: Schizophrenia Research
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