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Schizophrenia Research

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https://www.readbyqxmd.com/read/28214176/sex-differences-in-prolactin-levels-in-emerging-psychosis-indication-for-enhanced-stress-reactivity-in-women
#1
Sarah Ittig, Erich Studerus, Ulrike Heitz, Stephanie Menghini-Müller, Katharina Beck, Laura Egloff, Letizia Leanza, Christina Andreou, Anita Riecher-Rössler
BACKGROUND: Hyperprolactinemia is a known side effect of antipsychotics. In recent reports it has also been shown in antipsychotic-naïve at-risk mental state (ARMS) and first-episode psychosis (FEP) patients. Prolactin is not only involved in reproduction and lactation, but is also synthesized in response to stress. As stress is thought to play an important role in the onset and relapse of schizophrenia, the aim of this study was to further elucidate the influence of prolactin in emerging psychosis...
February 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28214175/the-traumatic-experience-of-first-episode-psychosis-a-systematic-review-and-meta-analysis
#2
Rebecca Rodrigues, Kelly K Anderson
INTRODUCTION: A psychotic episode may be sufficiently traumatic to induce symptoms of post-traumatic stress disorder (PTSD), which could impact outcomes in first-episode psychosis (FEP). The objectives of this systematic review and meta-analysis were to estimate the prevalence of PTSD symptoms in relation to psychosis in FEP and to identify risk factors for the development of PTSD symptoms. METHODS: We searched electronic databases and conducted manual searching of reference lists and tables of contents to identify relevant studies...
February 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28214174/the-effect-of-different-terror-exposures-on-the-course-of-schizophrenia-a-twenty-year-follow-up-of-a-random-sample
#3
LETTER
Y Weinstein, M Gelkopf, D Roe, S Z Levine
No abstract text is available yet for this article.
February 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28202292/specificity-and-nature-of-the-associations-of-twenty-four-neuropsychiatric-disorders-with-contacts-with-cats-and-dogs
#4
LETTER
Jaroslav Flegr, Milena Vedralova
No abstract text is available yet for this article.
February 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28202291/validation-of-schizophrenia-gene-expression-profile-in-a-preclinical-model-of-maternal-infection-during-pregnancy
#5
LETTER
Juan F Lopez-Gimenez, Mario de la Fuente Revenga, Fulgencio Ruso-Julve, Justin M Saunders, José L Moreno, Benedicto Crespo-Facorro, Javier González-Maeso
No abstract text is available yet for this article.
February 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28202290/effect-of-psychotropic-drug-treatment-on-sterol-metabolism
#6
Željka Korade, Wei Liu, Emily B Warren, Kristan Armstrong, Ned A Porter, Christine Konradi
Cholesterol metabolism is vital for brain function. Previous work in cultured cells has shown that a number of psychotropic drugs inhibit the activity of 7-dehydrocholesterol reductase (DHCR7), an enzyme that catalyzes the final steps in cholesterol biosynthesis. This leads to the accumulation of 7-dehydrocholesterol (7DHC), a molecule that gives rise to oxysterols, vitamin D, and atypical neurosteroids. We examined levels of cholesterol and the cholesterol precursors desmosterol, lanosterol, 7DHC and its isomer 8-dehydrocholesterol (8DHC), in blood samples of 123 psychiatric patients on various antipsychotic and antidepressant drugs, and 85 healthy controls, to see if the observations in cell lines hold true for patients as well...
February 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28190639/characterizing-white-matter-changes-in-chronic-schizophrenia-a-free-water-imaging-multi-site-study
#7
Lena K L Oestreich, Amanda E Lyall, Ofer Pasternak, Zora Kikinis, Dominick T Newell, Peter Savadjiev, Sylvain Bouix, Martha E Shenton, Marek Kubicki, Thomas J Whitford, Simon McCarthy-Jones
Diffusion tensor imaging (DTI) studies in chronic schizophrenia have found widespread but often inconsistent patterns of white matter abnormalities. These studies have typically used the conventional measure of fractional anisotropy, which can be contaminated by extracellular free-water. A recent free-water imaging study reported reduced free-water corrected fractional anisotropy (FAT) in chronic schizophrenia across several brain regions, but limited changes in the extracellular volume. The present study set out to validate these findings in a substantially larger sample...
February 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28189532/the-coupling-of-low-level-auditory-dysfunction-and-oxidative-stress-in-psychosis-patients
#8
Eveline Geiser, Chrysa Retsa, Jean-François Knebel, Carina Ferrari, Raoul Jenni, Margot Fournier, Luis Alameda, Philipp S Baumann, Stephanie Clarke, Philippe Conus, Kim Q Do, Micah M Murray
Patients diagnosed with schizophrenia often present with low-level sensory deficits. It is an open question whether there is a functional link between these deficits and the pathophysiology of the disease, e.g. oxidative stress and glutathione (GSH) metabolism dysregulation. Auditory evoked potentials (AEPs) were recorded from 21 psychosis disorder patients and 30 healthy controls performing an active, auditory oddball task. AEPs to standard sounds were analyzed within an electrical neuroimaging framework. A peripheral measure of participants' redox balance, the ratio of glutathione peroxidase and glutathione reductase activities (GPx/GR), was correlated with the AEP data...
February 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28189530/postmortem-studies-on-mitochondria-in-schizophrenia
#9
REVIEW
Rosalinda C Roberts
The aim of this paper is to provide a brief review of mitochondrial structure as it relates to function and then present abnormalities in mitochondria in postmortem schizophrenia with a focus on ultrastructure. Function, morphology, fusion, fission, motility, ΔΨmem, ATP production, mitochondrial derived vesicles, and mitochondria-associated ER membranes will be briefly covered. Pathology in mitochondria has long been implicated in schizophrenia, as shown by genetic, proteomic, enzymatic and anatomical abnormalities...
February 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28189531/development-and-validation-of-the-cannabis-experiences-questionnaire-intoxication-effects-checklist-ceq-i-short-form
#10
Catherine A Quinn, Hollie Wilson, Wendell Cockshaw, Emma Barkus, Leanne Hides
OBJECTIVE: To develop and validate a short form of the Cannabis Experiences Questionnaire - Intoxication Effects (CEQ-I), a 42-item scale which measures the euphoric and paranoid-dysphoric effects of cannabis intoxication. METHOD: Exploratory and confirmatory factor analyses were conducted among 604 past-month cannabis users to develop the short form. The factor structure was replicated in a second sample of 146 past-month cannabis users. The concurrent validity of the scale was also examined...
February 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28189529/initial-development-and-preliminary-psychometric-properties-of-the-prodromal-inventory-of-negative-symptoms-pins
#11
Andrea Pelletier-Baldelli, Gregory P Strauss, Katherine H Visser, Vijay A Mittal
In the psychosis prodrome, sub-threshold positive symptoms are often preceded by negative symptoms. Individuals exhibiting these attenuated symptoms are primarily adolescents and young adults at clinical high-risk (CHR) for developing a psychotic disorder. In the CHR state, negative symptoms are highly predictive of the transition to diagnosable illness, making the assessment of these symptoms very important. Existing scales used to evaluate negative symptoms in this critical population are informative but have conceptual and psychometric limitations and/or were not designed according to modern conceptions delineated in the 2005 NIMH Negative Symptom Consensus Conference...
February 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28187965/impact-of-rtms-on-functional-connectivity-within-the-language-network-in-schizophrenia-patients-with-auditory-hallucinations
#12
F Briend, E Leroux, N Delcroix, A Razafimandimby, O Etard, S Dollfus
This exploratory study investigated the functional connectivity (FC) in the language network in schizophrenia patients (SZ) with auditory verbal hallucinations (AVHs), and the therapeutic efficacy of rTMS on it. Eleven SZ with AVHs and 10 healthy controls (HC) underwent two fMRI sessions using a speech listening paradigm. SZ received 20Hz rTMS following the first fMRI session. Compared to HC, SZ showed a reduced FC in the language network. While AVHs improved after 12days, no changes in FC were observed. This suggests the efficacy of high-frequency rTMS on AVH without any impact for rTMS on FC within the language network...
February 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28185786/the-course-of-negative-symptoms-in-first-episode-schizophrenia-and-its-predictors-a-prospective-two-year-follow-up-study
#13
Gisela Mezquida, Bibiana Cabrera, Miquel Bioque, Silvia Amoretti, Antonio Lobo, Ana González-Pinto, Ana Espliego, Iluminada Corripio, Eduard Vieta, Josefina Castro-Fornieles, Daniel Bergé, Maria J Escartí, Ángela Ibañez, Rafael Penadés, Ana M Sánchez-Torres, Miguel Bernardo
AIMS: This study aimed to investigate the course of negative symptoms and its stability over a two-year period following a first-episode schizophrenia (FES) and the possible predictors of higher severity in this symptomatology after this period. METHODS: In this longitudinal two-year prospective follow-up study we included 268 patients with a FES, according to DSM-IV. Analysis of variance was conducted in patients who completed the full follow-up to study changes in negative symptoms over three visits...
February 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28185785/can-antibiotics-cause-a-psychosis-case-report-and-review-of-the-literature
#14
Duy Ly, Lynn E DeLisi
It is relatively unknown that some of the possible side effects of antibiotic treatment can be transient psychotic episodes and other encephalopathies such as seizure disorders. Since these are rare events, there have not been many studies about them, nor is there a clear understanding of the underlying basis for these symptoms. This phenomenon was recently brought to our attention by a patient whose case history is discussed here. For the past few years, he has been diagnosed at different times with schizophrenia, schizoaffective disorder, bipolar disorder with psychosis, temporal lobe epilepsy, and psychogenic nonepileptic seizures...
February 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28185784/does-integrated-neurocognitive-therapy-int-reduce-severe-negative-symptoms-in-schizophrenia-outpatients
#15
Daniel R Mueller, Zahra Khalesi, Valentin Benzing, Clelia I Castiglione, Volker Roder
Negative symptoms often inhibit the social integration of people suffering from schizophrenia. Reducing severe negative symptoms (SNS) in a clinically relevant way is a major unmet need. The aim of this study was to investigate whether Integrated Neurocognitive Therapy (INT), a group cognitive remediation therapy (CRT), reduces SNS in schizophrenia outpatients. INT was compared with Treatment As Usual (TAU) in a randomized-controlled trial (RCT). A total of 61 SNS outpatients participated in the study, 28 were allocated to the INT group and 33 to the TAU group...
February 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28185783/in-this-issue%C3%A2
#16
EDITORIAL
Lynn E DeLisi
No abstract text is available yet for this article.
February 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28179064/gaba-and-schizophrenia-where-we-stand-and-where-we-need-to-go
#17
Jill R Glausier, David A Lewis
No abstract text is available yet for this article.
February 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28179063/modelling-gene-environment-interaction-in-first-episodes-of-psychosis
#18
Miguel Bernardo, Miquel Bioque, Bibiana Cabrera, Antonio Lobo, Ana González-Pinto, Laura Pina, Iluminada Corripio, Julio Sanjuán, Anna Mané, Josefina Castro-Fornieles, Eduard Vieta, Celso Arango, Gisela Mezquida, Patricia Gassó, Mara Parellada, Jerónimo Saiz-Ruiz, Manuel J Cuesta, Sergi Mas
INTRODUCTION: Recent research demonstrates the heterogeneous etiology of psychotic disorders, where gen-environment (GxE) interaction plays a key role. Large genetic studies have linked many genetic variants with schizophrenia, but each variant is only associated with a small effect and the GxE interaction contribution has not been evaluated. METHODS: The PEPs Project was designed to carefully collect a large amount of genetic and environmental exposure data of 335 FEP patients and 253 matched healthy controls...
February 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28174035/pronounced-inhibition-related-hypofrontal-dysfunction-in-early-onset-schizophrenia-as-indexed-by-nogo-p300-amplitude
#19
LETTER
Anuradha Sharma, Melina Vogel, Matthias Weisbrod, Daniela Roesch-Ely, Rieke Oelkers-Ax
No abstract text is available yet for this article.
February 4, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28169087/adolescents-at-clinical-high-risk-for-psychosis-circadian-rhythm-disturbances-predict-worsened-prognosis-at-1-year-follow-up
#20
Jessica R Lunsford-Avery, Bruno da Silva Brandão Gonçalves, Elisa Brietzke, Rodrigo A Bressan, Ary Gadelha, Randy P Auerbach, Vijay A Mittal
BACKGROUND: Individuals with psychotic disorders experience disruptions to both the sleep and circadian components of the sleep/wake cycle. Recent evidence has supported a role of sleep disturbances in emerging psychosis. However, less is known about how circadian rhythm disruptions may relate to psychosis symptoms and prognosis for adolescents with clinical high-risk (CHR) syndromes. The present study examines circadian rest/activity rhythms in CHR and healthy control (HC) youth to clarify the relationships among circadian rhythm disturbance, psychosis symptoms, psychosocial functioning, and the longitudinal course of illness...
February 4, 2017: Schizophrenia Research
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