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Schizophrenia Research

Sanghyeon Kim, Yousang Jo, Maree J Webster, Doheon Lee
Previous studies on the brain of people with schizophrenia have identified structural changes and gene expression changes, suggesting that brain aging maybe accelerated in people with schizophrenia. To better characterize gene expression profiles in schizophrenia and in the aged population we constructed co-expression networks using RNA-Seq data from frontal cortex. The first data set analysed was from 62 subjects with schizophrenia and 51 unaffected controls ranging in age from 19 to 63 years. The second separate data set was from normal control individuals ranging in age from 29 to 106 years...
September 14, 2018: Schizophrenia Research
Md Shaki Mostaid, Stefanos Dimitrakopoulos, Cassandra Wannan, Vanessa Cropley, Cynthia Shannon Weickert, Ian P Everall, Christos Pantelis, Chad A Bousman
We investigated IL1B genetic variation previously associated with risk for transition to psychosis for its association with gene expression in human post-mortem dorsolateral prefrontal cortex (DLPFC) from 74 (37 schizophrenia, 37 control) individuals and brain structure in 92 (44 schizophrenia, 48 control) living individuals. The IL1B A-G-T 'risk for psychosis transition' haplotype (rs16944|rs4848306|rs12621220) was associated with upregulation of IL1B mRNA expression in the DLPFC as well as reduced total grey matter and left middle frontal volumes and enlarged left lateral ventricular volume...
September 14, 2018: Schizophrenia Research
Anselm B M Fuermaier, Dafne Piersma, Rafaele J C Huntjens, Dick de Waard, Celina Westermann, Magdalena Bossert, Klaus W Lange, Matthias Weisbrod, Richard Bruggeman, Steffen Aschenbrenner, Oliver Tucha
OBJECTIVES: Patients with schizophrenia commonly suffer from impairments in various aspects of cognition. These deficits were shown to have detrimental effects on daily life functioning and might also impair car driving. This study is the first to examine driving behaviour of patients with schizophrenia using an advanced driving simulator, and to explore the role of cognitive abilities of people with schizophrenia for driving. METHODS: Non-acute patients with schizophrenia (n = 31) and healthy comparison participants (n = 31) performed a comprehensive neuropsychological assessment and driving simulator rides...
September 12, 2018: Schizophrenia Research
Kazunori Matsumoto, Masahiro Katsura, Naohisa Tsujino, Shimako Nishiyama, Takahiro Nemoto, Naoyuki Katagiri, Tsutomu Takahashi, Yuko Higuchi, Noriyuki Ohmuro, Hiroo Matsuoka, Michio Suzuki, Masafumi Mizuno
There has been recent accumulation of evidence and clinical guidance regarding the at-risk mental state (ARMS) for psychosis. However, most studies have been observational cohort and intervention studies of Western populations. To assess the validity of the ARMS concept and the transition rate to psychosis in a non-Western nation, we retrospectively combined and analyzed clinical data of individuals diagnosed with ARMS who were prospectively followed-up at three specialized clinical services for ARMS in Japan...
September 12, 2018: Schizophrenia Research
Elizabeth Thompson, Pamela Rakhshan, Steven C Pitts, Caroline Demro, Zachary B Millman, Kristin Bussell, Jordan DeVylder, Emily Kline, Gloria M Reeves, Jason Schiffman
BACKGROUND: Youth at clinical high-risk (CHR) for psychosis often experience difficulties in social and role functioning. Given evidence that family stress and support can impact psychosis-risk symptoms, as well as an individual's ability to fulfill social and role functions, family dynamics are hypothesized to moderate the effect of psychosis-risk symptoms on functioning. METHODS: Participants at CHR (N = 52) completed the clinician-administered Structured Interview for Psychosis-risk Syndromes (SIPS) and the Family Assessment Device (FAD) General Functioning Scale, a self-report measure of family functioning including cohesion and support...
September 8, 2018: Schizophrenia Research
Błażej Misiak, Kamila Kotowicz, Olga Loska, Filip Stramecki, Jan Aleksander Beszłej, Jerzy Samochowiec, Agnieszka Samochowiec, Marcin Jabłoński, Piotr Podwalski, Katarzyna Waszczuk, Michał Wroński, Anna Michalczyk, Leszek Sagan, Patryk Piotrowski
No abstract text is available yet for this article.
September 7, 2018: Schizophrenia Research
Thiago Monteiro Paiva Fernandes, Steven M Silverstein, Pamela D Butler, Szabolcs Kéri, Lucas Galdino Santos, Renata Lyra Nogueira, Natanael Antonio Santos
Schizophrenia patients (SCZ) demonstrate deficits in many domains of mental functioning, including visual perception. An issue that has been relatively unexplored, in terms of explaining variation in visual function in SCZ, however, is medication use. The present study explored potential medication effects on color vision in SCZ, a process that is strongly linked to dopaminergic function in the retina. SCZ patients who had clear-cut either typical (n = 29) or atypical (n = 29) monotherapy, without any other concurrent medication, and a group of age- and gender-matched healthy controls participated in the study...
September 7, 2018: Schizophrenia Research
Tovah Cowan, Thanh P Le, Brita Elvevåg, Peter W Foltz, Raymond P Tucker, Terje B Holmlund, Alex S Cohen
This study compared static predictors of hostility (e.g. demographics, clinician ratings) to subjective (i.e., self-reported affect on slider scales in response to written questions) and objective (i.e., vocal indicators of arousal from speech samples in a story-retelling task) dynamic predictors using ambulatory assessment over five days in a sample of 25 stable outpatients with diagnoses of a serious mental illness. Multilevel modeling showed that both subjective and objective dynamic predictors were significant, but none of the static predictors were...
September 6, 2018: Schizophrenia Research
Tobias Rowland, Maximillian Birchwood, Swaran Singh, Nicholas Freemantle, Linda Everard, Peter Jones, David Fowler, Tim Amos, Max Marshall, Vimal Sharma, Andrew Thompson
BACKGROUND: Previous evidence suggests that delusional disorder has a later onset and better functional outcomes compared to schizophrenia. However, studies have not examined longitudinal outcomes in a first episode population, where confounding factors may be adjusted for. METHODS: A nested case control study was designed within the National EDEN study; a cohort of 1027 first episode psychosis patients. Patients with a baseline diagnosis of delusional disorder (n = 48) were compared with schizophrenia (n = 262) at 6 and 12 months with respect to symptomatic and functional outcomes...
September 5, 2018: Schizophrenia Research
Jennifer R Lepock, Romina Mizrahi, Michele Korostil, Margaret Maheandiran, Cory J Gerritsen, Lauren Drvaric, Sarah Ahmed, R Michael Bagby, Michael Kiang
No abstract text is available yet for this article.
September 4, 2018: Schizophrenia Research
Teresa Vargas, K Juston Osborne, Emily S Cibelli, Vijay A Mittal
No abstract text is available yet for this article.
September 4, 2018: Schizophrenia Research
Thomas A Macek, Maggie McCue, Xinxin Dong, Elizabeth Hanson, Paul Goldsmith, John Affinito, Atul R Mahableshwarkar
INTRODUCTION: TAK-063 is a potent, selective inhibitor of phosphodiesterase 10A, an enzyme selectively expressed in medium spiny neurons of the striatum. This randomized, parallel-group study evaluated the efficacy and safety of 20-mg daily TAK-063 versus placebo in subjects with acutely exacerbated symptoms of schizophrenia (NCT02477020). METHODS: Adults aged 18 to 65 with diagnosed schizophrenia and psychotic symptoms that exacerbated within 60 days before screening were included...
September 3, 2018: Schizophrenia Research
M K Shakeel, L Lu, T D Cannon, K S Cadenhead, B A Cornblatt, T H McGlashan, D O Perkins, L J Seidman, M T Tsuang, S W Woods, E F Walker, D H Mathalon, C E Bearden, J Addington
Social cognition deficits have been observed in individuals at clinical high risk (CHR) for psychosis. Longitudinal change in social cognition were analyzed in CHR individuals from the North American Prodrome Longitudinal Study (NAPLS2) based on outcome at 24 months. Individuals (n = 359) were classified into remission, symptomatic, prodromal progression and transition to psychosis (CHR-T) groups. Social cognition was assessed using theory of mind, emotion perception, and social perception tasks. There were no differences at baseline or 24 months between the groups on social cognition...
September 1, 2018: Schizophrenia Research
Giuseppe Carrà, Cristina Crocamo, Matthias Angermeyer, Traolach Brugha, Mondher Toumi, Paul Bebbington
BACKGROUND: Recent network models of schizophrenia propose it is the consequence of mutual interaction between its symptoms. While cross-sectional associations between negative and positive symptoms are consistent with this idea, they may merely reflect their involvement in the diagnostic process. Longitudinal analyses however may allow the identification of possible causal relationships. The European Schizophrenia Cohort (EuroSC) provides data suitable for this purpose. METHODS: EuroSC includes 1208 patients randomly sampled from outpatient services in France, Germany and the UK...
August 31, 2018: Schizophrenia Research
Linghui Meng, Kaiming Li, Wenbin Li, Yuan Xiao, Su Lui, John A Sweeney, Qiyong Gong
Potential effects of initiating acute antipsychotic treatment on white matter (WM) microstructure in schizophrenia patients remain poorly characterized. Thirty-five drug-naïve first-episode schizophrenia patients were scanned before and after six weeks of treatment with second-generation antipsychotic medications. Nineteen demographically matched healthy subjects were scanned twice over the same time interval. Tract-based spatial statistics was used to test for changes in WM microstructural integrity after treatment...
August 31, 2018: Schizophrenia Research
Eleanor Carey, Niamh Dooley, Diane Gillan, Colm Healy, Helen Coughlan, Mary Clarke, Ian Kelleher, Mary Cannon
OBJECTIVE: To identify neuropsychological and motor changes from adolescence to early adulthood in young people with psychotic experiences (PE). METHODS: A community-based sample of 56 young people attended the study over a 9 year follow-up period. Participants were assessed over 3 time-points at T1, T2 and T3 aged x¯ = 11.69, x¯ = 15.80 and x¯ = 18.80 years respectively. PE were assessed using the Kiddie Schedule for Affective and Depressive Symptoms (K-SADS)...
August 30, 2018: Schizophrenia Research
Kally C O'Reilly, Maria I Perica, André A Fenton
Activity-dependent changes in the effective connection strength of synapses are a fundamental feature of a nervous system. This so-called synaptic plasticity is thought to underlie storage of information in memory and has been hypothesized to be crucial for the effects of cognitive behavioral therapy. Synaptic plasticity stores information in a neural network, creating a trace of neural activity from past experience. The plasticity can also change the behavior of the network so the network can differentially transform/compute information in future activations...
August 30, 2018: Schizophrenia Research
Willie Earley, Hua Guo, David Daniel, Henry Nasrallah, Suresh Durgam, Yan Zhong, Mehul Patel, Ágota Barabássy, Balázs Szatmári, György Németh
Although currently approved antipsychotics exert efficacy on positive symptoms of schizophrenia, treatments for negative symptoms remain a major unmet need. Post hoc analyses were used to investigate the possible efficacy of cariprazine in patients with moderate/severe negative symptoms of schizophrenia and no predominance of positive symptoms. Data were pooled from 2 randomized, double-blind, placebo- and active-controlled cariprazine studies in patients with acute schizophrenia (NCT00694707, NCT01104766)...
August 29, 2018: Schizophrenia Research
Steffen Moritz, Anja Fritzsche, Maike Engel, Jule Meiseberg, Stefan Klingberg, Klaus Hesse
No abstract text is available yet for this article.
August 29, 2018: Schizophrenia Research
Laura Sichlinger, Emily Cibelli, Matthew Goldrick, Vijay A Mittal
No abstract text is available yet for this article.
August 29, 2018: Schizophrenia Research
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