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Schizophrenia Research

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https://www.readbyqxmd.com/read/29789256/systems-level-analysis-of-risk-genes-reveals-the-modular-nature-of-schizophrenia
#1
Jiewei Liu, Ming Li, Xiong-Jian Luo, Bing Su
Schizophrenia (SCZ) is a complex mental disorder with high heritability. Genetic studies (especially recent genome-wide association studies) have identified many risk genes for schizophrenia. However, the physical interactions among the proteins encoded by schizophrenia risk genes remain elusive and it is not known whether the identified risk genes converge on common molecular networks or pathways. Here we systematically investigated the network characteristics of schizophrenia risk genes using the high-confidence protein-protein interactions (PPI) from the human interactome...
May 19, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29785932/cortical-thickness-correlates-of-minor-neurological-signs-in-patients-with-first-episode-psychosis
#2
Simone Ciufolini, Maria Francesca Ponteduro, Tiago Reis-Marques, Heather Taylor, Valeria Mondelli, Carmine M Pariante, Stefania Bonaccorso, Raymond Chan, Andy Simmons, Anthony David, Marta Di Forti, Robin M Murray, Paola Dazzan
Neurological soft signs (NSS) are subtle abnormalities of motor and sensory function that are present in the absence of localized brain pathological lesions. In psychoses they have been consistently associated with a distinct pattern of cortical and subcortical brain structural alterations at the level of the heteromodal cortex and basal ganglia. However, a more specific and accurate evaluation of the cytoarchitecture of the cortical mantle could further advance our understanding of the neurobiological substrate of psychosis...
May 18, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29779964/childhood-trauma-and-clinical-high-risk-for-psychosis
#3
Rachel L Loewy, Sarah Corey, Felix Amirfathi, Sawsan Dabit, Daniel Fulford, Rahel Pearson, Jessica P Y Hua, Danielle Schlosser, Barbara K Stuart, Daniel H Mathalon, Sophia Vinogradov
As a risk factor for psychosis, childhood trauma rates are elevated in the clinical-high-risk (CHR) syndrome compared to the general population. However, it is unknown whether trauma is typically experienced in childhood or adolescence/young adulthood, whether it occurred prior to CHR syndrome onset, and how severe trauma relates to presenting symptoms. In this study, we examined the relationship of trauma history to symptoms and functioning in individuals diagnosed with the CHR syndrome on the Structured Interview for Psychosis-Risk Syndromes (N = 103)...
May 18, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29778295/of-minds-and-men-suits-spirits-and-psychosis
#4
LETTER
Edward Christopher Dee
No abstract text is available yet for this article.
May 17, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29778294/the-association-between-psychotic-experiences-and-health-related-quality-of-life-a-cross-national-analysis-based-on-world-mental-health-surveys
#5
Jordi Alonso, Sukanta Saha, Carmen C W Lim, Sergio Aguilar-Gaxiola, Ali Al-Hamzawi, Corina Benjet, Evelyn J Bromet, Louisa Degenhardt, Giovanni de Girolamo, Oluyomi Esan, Silvia Florescu, Oye Gureje, Josep M Haro, Chiyi Hu, Elie G Karam, Georges Karam, Viviane Kovess-Masfety, Jean-Pierre Lepine, Sing Lee, Zeina Mneimneh, Fernando Navarro-Mateu, Jose Posada-Villa, Nancy A Sampson, Kate M Scott, Juan Carlos Stagnaro, Margreet Ten Have, Maria Carmen Viana, Ronald C Kessler, John J McGrath
Psychotic experiences (PEs) are associated with a range of mental and physical disorders, and disability, but little is known about the association between PEs and aspects of health-related quality of life (HRQoL). We aimed to investigate the association between PEs and five HRQoL indicators with various adjustments. Using data from the WHO World Mental Health surveys (n = 33,370 adult respondents from 19 countries), we assessed for PEs and five HRQoL indicators (self-rated physical or mental health, perceived level of stigma (embarrassment and discrimination), and social network burden)...
May 16, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29776641/cortisol-awakening-response-is-decreased-in-patients-with-first-episode-psychosis-and-increased-in-healthy-controls-with-a-history-of-severe-childhood-abuse
#6
Simone Ciufolini, Charlotte Gayer-Anderson, Helen L Fisher, Tiago Reis Marques, Heather Taylor, Marta Di Forti, Patricia Zunszain, Craig Morgan, Robin M Murray, Carmine M Pariante, Paola Dazzan, Valeria Mondelli
BACKGROUND: Childhood abuse is highly prevalent in psychosis patients, but whether/how it affects hypothalamic-pituitary-adrenal (HPA) axis at the onset of psychosis remains unclear. We aimed to investigate the effects of severity of childhood abuse on HPA axis activity, in first-episode psychosis (FEP) and healthy controls. METHODS: We recruited 169 FEP patients and 133 controls with different degrees of childhood physical and sexual abuse (i.e. no abuse exposure, non-severe abuse exposure, and severe abuse exposure)...
May 15, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29764760/altered-predictive-capability-of-the-brain-network-eeg-model-in-schizophrenia-during-cognition
#7
Javier Gomez-Pilar, Jesús Poza, Carlos Gómez, Georg Northoff, Alba Lubeiro, Benjamín B Cea-Cañas, Vicente Molina, Roberto Hornero
The study of the mechanisms involved in cognition is of paramount importance for the understanding of the neurobiological substrates in psychiatric disorders. Hence, this research is aimed at exploring the brain network dynamics during a cognitive task. Specifically, we analyze the predictive capability of the pre-stimulus theta activity to ascertain the functional brain dynamics during cognition in both healthy and schizophrenia subjects. Firstly, EEG recordings were acquired during a three-tone oddball task from fifty-one healthy subjects and thirty-five schizophrenia patients...
May 12, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29764759/development-and-validation-of-the-client-engagement-and-service-use-scale-a-pilot-study
#8
Emily R Kline, Nicole R DeTore, Kristen Keefe, Larry J Seidman, Vinod H Srihari, Matcheri S Keshavan, Margaret Guyer
Specialized treatment for first episode psychosis offers clients a menu of services coordinated within a specialized treatment team. To enhance the impact of these services, promoting engagement and preventing early treatment drop-out is critical. However, engagement is poorly tracked and typically quantified through proxy variables such as session attendance, medication adherence, or working alliance. The aim of this study is to introduce and pilot a new measure of engagement for first episode psychosis coordinated specialty care, the Client Engagement and Service Use Scale (CENSUS)...
May 12, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29764758/reality-testing-of-the-efficacy-of-tdcs-on-auditory-hallucinations-in-schizophrenia
#9
LETTER
Robert J Morgan, Balwinder Singh
No abstract text is available yet for this article.
May 12, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29759351/dysbindin-1-contributes-to-prefrontal-cortical-dendritic-arbor-pathology-in-schizophrenia
#10
Glenn T Konopaske, Darrick T Balu, Kendall T Presti, Grace Chan, Francine M Benes, Joseph T Coyle
Deep layer III pyramidal cells in the dorsolateral prefrontal cortex (DLPFC) from subjects with schizophrenia and bipolar disorder previously were shown to exhibit dendritic arbor pathology. This study sought to determine whether MARCKS, its regulatory protein dysbindin-1, and two proteins, identified using microarray data, CDC42BPA and ARHGEF6, were associated with dendritic arbor pathology in the DLPFC from schizophrenia and bipolar disorder subjects. Using western blotting, relative protein expression was assessed in the DLPFC (BA 46) grey matter from subjects with schizophrenia (n = 19), bipolar disorder (n = 17) and unaffected control subjects (n = 19)...
May 11, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29759350/poor-oral-health-in-patients-with-schizophrenia-a-systematic-review-and-meta-analysis
#11
REVIEW
Mi Yang, Peng Chen, Man-Xi He, Min Lu, Hong-Ming Wang, Jair C Soares, Xiang-Yang Zhang
Increased rates of comorbid physical illness have been commonly reported in patients with schizophrenia. However, there are fewer data on dental disease in these patients. We systematically evaluated existing data on the oral health survey of schizophrenia patients through meta-analysis. Using the available databases, we performed a systematic search to identify the studies examining the oral health in schizophrenia patients from January 1997 to June 2017, based on the inclusion and exclusion criteria. Two investigators extracted the related data independently...
May 11, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29754761/sexual-abuse-and-psychosis-the-security-of-research-findings
#12
Paul E Bebbington
No abstract text is available yet for this article.
May 10, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29751984/age-related-trajectories-of-social-cognition-in-youth-at-clinical-high-risk-for-psychosis-an-exploratory-study
#13
Charlie A Davidson, Danijela Piskulic, Jean Addington, Kristen S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Thomas H McGlashan, Diana O Perkins, Larry J Seidman, Ming T Tsuang, Elaine F Walker, Carrie E Bearden, Daniel H Mathalon, Scott W Woods, Jason K Johannesen
BACKGROUND: Clinical high risk (CHR) status is characterized by impairments in social cognition, but questions remain concerning their stability over development. In cross-sectional analysis of a large naturalistic sample, the current study examined whether those at CHR status show deviant trajectories for age-related change in social cognitive ability, and whether these trajectories are influenced by treatment history. METHOD: Emotion perception (EP) and theory of mind (ToM) were assessed in 675 CHR and 263 healthy comparison (HC) participants aged 12-35...
May 8, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29743139/the-relationship-between-the-level-of-exposure-to-stress-factors-and-cannabis-in-recent-onset-psychosis
#14
Sara Arranz, Nuria Monferrer, M Jose Algora, Angel Cabezas, Montse Sole, E Vilella, J Labad, Vanessa Sanchez-Gistau
BACKGROUND: There is a lack of studies investigating the dose-response effect of childhood trauma, recent events and cannabis use on recent psychosis. This study aims to determine the relationship between the level of exposure to stress factors and cannabis use with psychosis and to determine the combination effect among these factors in predicting a psychotic disorder. METHODS: 146 recent onset psychotic (ROP) patients and 61 healthy controls were included. Childhood trauma was evaluated using the childhood trauma questionnaire (CTQ) and recent events using the Holmes-Rahe social readjustment scale...
May 6, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29735201/enhancing-stress-reactivity-and-wellbeing-in-early-schizophrenia-a-pilot-study-of-individual-coping-awareness-therapy-i-cat
#15
LETTER
Piper S Meyer-Kalos, Kelsey A Ludwig, Susan Gaylord, Diana O Perkins, Karen Grewen, Olafur S Palsson, Margaret Burchinal, David L Penn
No abstract text is available yet for this article.
May 4, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29735200/polygenic-risk-score-and-the-neuro-developmental-ontogenesis-of-the-schizophrenia-spectrum-vulnerability-phenotypes
#16
LETTER
Michele Poletti, Andrea Raballo
No abstract text is available yet for this article.
May 4, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29730044/association-between-catechol-o-methyltransferase-genetic-variation-and-functional-connectivity-in-patients-with-first-episode-schizophrenia
#17
Hongyan Wang, Bin Zhang, Botao Zeng, Yingying Tang, Tianhong Zhang, Shanshan Zhao, Chunbo Li, Jijun Wang, Donald C Goff
Dopamine in the prefrontal cortex (PFC) plays an important role in cognitive performance and regulates by catechol-O-methyltransferase (COMT) expression. To clarify the effect of COMT genotype on cognitive function in patients with schizophrenia, we performed DNA genotyping, cognitive evaluations, and functional magnetic resonance imaging (fMRI) in antipsychotic-naïve patients with first-episode schizophrenia (FES) and matched healthy control subjects. We found that all cognitive domains were impaired in patients with FES compared with healthy subjects...
May 3, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29730045/improving-cognitive-training-for-schizophrenia-using-neuroplasticity-enhancers-lessons-from-decades-of-basic-and-clinical-research
#18
G D Guercio, M E Thomas, J M Cisneros-Franco, P Voss, R Panizzutti, E de Villers-Sidani
Mounting evidence indicates that schizophrenia is a disorder that stems from maladaptive plasticity within neural circuits and produces broad cognitive deficits leading to loss of autonomy. A large number of studies have identified abnormalities spanning many neurotransmitter systems in schizophrenia, and as a result, a variety of drugs have been developed to attempt to treat these abnormalities and enhance cognition. Unfortunately, positive results have been limited so far. This may be in part because the scope of abnormalities in the schizophrenic brain requires a treatment capable of engaging many different neurotransmitter systems...
May 2, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29730043/identifying-the-genetic-risk-factors-for-treatment-response-to-lurasidone-by-genome-wide-association-study-a-meta-analysis-of-samples-from-three-independent-clinical-trials
#19
Jiang Li, Antony Loebel, Herbert Y Meltzer
A genome-wide association study (GWAS) of response of schizophrenia patients to the atypical antipsychotic drug, lurasidone, based on two double-blind registration trials, identified SNPs from four classes of genes as predictors of efficacy, but none were genome wide significant (GWS). After inclusion of data from a third lurasidone trial, meta-analysis identified a GWS marker and other findings consistent with our first study. The primary end-point was change in Total Positive and Negative Syndrome Scale (PANSS) between baseline and last observation carried forward...
May 2, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29709491/resting-state-network-connectivity-and-metastability-predict-clinical-symptoms-in-schizophrenia
#20
Won Hee Lee, Gaelle E Doucet, Evan Leibu, Sophia Frangou
BACKGROUND: The functional architecture of resting-state networks (RSNs) is defined by their connectivity and metastability. Disrupted RSN connectivity has been amply demonstrated in schizophrenia while the role of metastability remains poorly defined. Here, we undertake a comprehensive characterisation of RSN organization in schizophrenia and test its contribution to the clinical profile of this disorder. METHODS: We extracted RSNs representing the default mode (DMN), central executive (CEN), salience (SAL), language (LAN), sensorimotor (SMN), auditory (AN) and visual (VN) networks from resting-state functional magnetic resonance imaging data obtained from patients with schizophrenia (n = 85) and healthy individuals (n = 48)...
April 27, 2018: Schizophrenia Research
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