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Schizophrenia Research

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https://www.readbyqxmd.com/read/29146021/symptom-dimensions-and-subgroups-in-childhood-onset-schizophrenia
#1
Kirsten E S Craddock, Xueping Zhou, Siyuan Liu, Peter Gochman, Dwight Dickinson, Judith L Rapoport
OBJECTIVE: This study investigated symptom dimensions and subgroups in the National Institute of Mental Health (NIMH) childhood-onset schizophrenia (COS) cohort and their similarities to adult-onset schizophrenia (AOS) literature. METHOD: Scores from the Scales for the Assessment of Positive and Negative Symptoms (SAPS & SANS) from 125 COS patients were assessed for fit with previously established symptom dimensions from AOS literature using confirmatory factor analysis (CFA)...
November 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29146020/clinical-and-demographic-predictors-of-continuing-remission-or-relapse-following-discontinuation-of-antipsychotic-medication-after-a-first-episode-of-psychosis-a-systematic-review
#2
REVIEW
Meghan Bowtell, Aswin Ratheesh, Patrick McGorry, Eoin Killackey, Brian O'Donoghue
BACKGROUND: Clinical guidelines recommend maintenance treatment with antipsychotic medication for one to two years following remission of symptoms after a first episode of psychosis. However, recent research has suggested that this may not be indicated. Consistent predictors of outcome would be beneficial to guide clinicians as to which individuals are likely to have a successful discontinuation. OBJECTIVES: This study reviews the literature with the aim of identifying demographic and clinical predictors of either relapse or continued remission in those with a first episode of psychosis following discontinuation of antipsychotic medication...
November 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29146019/every-day-coincidences-and-referential-thinking-differentiating-normative-experiences-from-symptoms-in-psychosis
#3
LETTER
K Juston Osborne, Vijay A Mittal
No abstract text is available yet for this article.
November 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29141785/environmental-adversities-and-psychotic-symptoms-the-impact-of-timing-of-trauma-abuse-and-neglect
#4
Inga Schalinski, Susanne Breinlinger, Vanessa Hirt, Martin H Teicher, Michael Odenwald, Brigitte Rockstroh
BACKGROUND: Trauma and adverse childhood experiences (ACE) occur more often in mental illness, including psychosis, than in the general population. Individuals with psychosis (cases) report a higher number and severity (dose) of adversities than healthy controls. While a dose-dependent increase of adversities has been related to more severe psychopathology, the role of type and timing is still insufficiently understood on the exacerbation of positive and negative psychotic symptoms. Moreover, dissociative symptoms were examined as potential mediator between adversities and severity of psychotic symptoms...
November 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29137828/differentiating-between-clinical-and-behavioral-phenotypes-in-first-episode-psychosis-during-maintenance-of-visuospatial-working-memory
#5
Maria Jalbrzikowski, Vishnu P Murty, Patricia L Stan, Jusmita Saifullan, Daniel Simmonds, William Foran, Beatriz Luna
INTRODUCTION: We probed the neural basis of working memory in individuals with first episode of psychosis (FEP) and assessed how these neural abnormalities are associated with behavioral performance and/or core to psychosis pathophysiology. METHODS: FEP (N=35) and matched controls (N=25) performed a visuospatial working memory task during fMRI acquisition. We isolated neural activity during the maintenance period and examined neural activity within regions typically engaged during a working memory task...
November 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29132815/impaired-mismatch-negativity-to-frequency-deviants-in-individuals-at-ultra-high-risk-for-psychosis-and-preliminary-evidence-for-further-impairment-with-transition-to-psychosis
#6
Suzie Lavoie, Bradley N Jack, Oren Griffiths, Ayaka Ando, Paul Amminger, Anthony Couroupis, Aidan Jago, Connie Markulev, Patrick D McGorry, Barnaby Nelson, Andrea Polari, Hok Pan Yuen, Thomas J Whitford
BACKGROUND: There is evidence to suggest that people with established psychotic disorders show impairments in the mismatch negativity induced by a frequency-deviant sound (fMMN), and that these impairments worsen with the deterioration of psychotic symptoms. This study aimed to test whether individuals at ultra-high risk (UHR) for psychosis show pre-morbid impairments in fMMN, and if so, whether fMMN continues to deteriorate with transition to psychosis. METHOD: fMMN was recorded in a cohort of UHR individuals (n=42) and compared to healthy controls (n=29)...
November 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29132814/incidence-of-child-and-adolescent-mental-disorders-in-children-aged-0-17-with-familial-high-risk-for-severe-mental-illness-a-danish-register-study
#7
Anne A E Thorup, Thomas Munk Laursen, Trine Munk-Olsen, Anne Ranning, Preben Bo Mortensen, Kerstin J Plessen, Merete Nordentoft
BACKGROUND: Offspring of parents with severe mental illness (SMI: schizophrenia, bipolar disorder or major depressive disorder) have an increased risk of developing mental disorder themselves. In childhood they may have neurodevelopmental delays, cognitive deficits and social adversities. We aimed to investigate if these individuals are more at risk of being diagnosed with a mental disorder during childhood/adolescence in a national sample. METHODS: By linking Danish registers we established a cohort consisting of all persons born to parents with SMI with those born to parents without SMI serving as a reference group...
November 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29132813/mismatch-negativity-a-simple-and-useful-biomarker-of-n-methyl-d-aspartate-receptor-nmdar-type-glutamate-dysfunction-in-schizophrenia
#8
Michael Avissar, Daniel Javitt
No abstract text is available yet for this article.
November 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29129508/-ethnic-density-of-neighbourhood-at-age-15-modifies-the-risk-for-psychosis-so-what
#9
Jean-Paul Selten, Fabian Termorshuizen
No abstract text is available yet for this article.
November 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29129504/cognitive-therapy-of-psychosis-research-and-implementation
#10
David Kingdon, Douglas Turkington
No abstract text is available yet for this article.
November 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29129510/increase-in-serum-hdl-level-is-associated-with-less-negative-symptoms-after-one-year-of-antipsychotic-treatment-in-first-episode-psychosis
#11
Priyanthi B Gjerde, Ingrid Dieset, Carmen Simonsen, Eva Z Hoseth, Trude Iversen, Trine V Lagerberg, Siv Hege Lyngstad, Ragni H Mørch, Silje Skrede, Ole A Andreassen, Ingrid Melle, Vidar M Steen
BACKGROUND: A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated with alleviation of psychosis symptoms after one year of antipsychotic drug treatment in a cohort of first-episode psychosis (FEP) patients. METHODS: A total of 132 non-affective antipsychotic-treated FEP patients were included through the Norwegian Thematically Organized Psychosis (TOP) project...
November 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29129509/reduced-dorsolateral-prefrontal-cortex-activation-during-affective-go-nogo-in-violent-schizophrenia-patients-an-fmri-study
#12
Andràs Tikàsz, Stéphane Potvin, Stéphane Richard-Devantoy, Olivier Lipp, Sheilagh Hodgins, Pierre Lalonde, Ovidiu Lungu, Alexandre Dumais
We investigated the influence of anger processing on cognitive control in male schizophrenia patients presenting violent behaviors. We recruited 23 patients without and 24 patients with (SCZ+V) a history of violent behaviors, as well as 22 healthy non-violent men. Participants were administered an affective (angry-neutral faces) Go/NoGo task while undergoing functional magnetic resonance imaging. We found a reduced activation in the dorsolateral prefrontal cortex in SCZ+V patients specifically when inhibiting a response while viewing angry faces...
November 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29129507/the-use-of-polygenic-risk-scores-to-identify-phenotypes-associated-with-genetic-risk-of-schizophrenia-systematic-review
#13
REVIEW
Sumit Mistry, Judith R Harrison, Daniel J Smith, Valentina Escott-Price, Stanley Zammit
Studying the phenotypic manifestations of increased genetic liability for schizophrenia can increase our understanding of this disorder. Specifically, information from alleles identified in genome-wide association studies can be collapsed into a polygenic risk score (PRS) to explore how genetic risk is manifest within different samples. In this systematic review, we provide a comprehensive assessment of studies examining associations between schizophrenia PRS (SZ-PRS) and several phenotypic measures. We searched EMBASE, Medline and PsycINFO (from August 2009-14th March 2016) plus references of included studies, following PRISMA guidelines...
November 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29129506/clinical-insights-addressing-command-hallucinations
#14
Michelle L West
No abstract text is available yet for this article.
November 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29129505/discontinuing-antipsychotic-treatment-after-a-first-episode-of-psychosis-who-when-and-how
#15
Robin Emsley
No abstract text is available yet for this article.
November 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29128323/who-needs-antipsychotic-maintenance-treatment-and-who-does-not-our-need-to-profile-and-personalize-the-treatment-of-first-episode-psychosis
#16
Lex Wunderink
No abstract text is available yet for this article.
November 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29128326/cognitive-remediation-can-improve-negative-symptoms-and-social-functioning-in-first-episode-schizophrenia-a-randomized-controlled-trial
#17
Joseph Ventura, Kenneth L Subotnik, Denise Gretchen-Doorly, Laurie Casaus, Michael Boucher, Gerhard S Hellemann, Keith H Nuechterlein
BACKGROUND: Meta-analyses have reported that the effects of cognitive remediation might go beyond improvement in cognition to include unexpected benefits for schizophrenia patients such as negative symptom reduction and improvements in functioning. In addition, some evidence indicated that these potentially beneficial effects are also present in the initial course of schizophrenia, but work in this area is still developing. METHOD: A RCT compared Cognitive Remediation (CR) to Healthy Behaviors Training (HBT) in 80 patients (78% male) with a mean age of 21...
November 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29128325/aripiprazole-induced-tardive-dyskinesia-in-patients-with-schizophrenia-a-case-report-of-twins
#18
LETTER
Shenglin She, Qijie Kuang, Yingjun Zheng
No abstract text is available yet for this article.
November 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29128324/overlooked-fatal-infectious-diseases-after-long-term-antipsychotic-use-in-patients-with-psychiatric-illness
#19
Liliang Li, Xing Ye, Ziqin Zhao, Pan Gao, Yan Jiang
No abstract text is available yet for this article.
November 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29126609/meta-analysis-of-adult-height-and-birth-length-in-schizophrenia
#20
Keely Latham, Brian Kirkpatrick
OBJECTIVE: As a group, people with schizophrenia have a number of subtle anatomical abnormalities as well as physiological abnormalities that precede antipsychotic treatment. Some studies have also found shorter birth length or shorter adult height in people with schizophrenia compared to control subjects. We performed a systematic review and meta-analysis of studies of birth length and adult height in schizophrenia, following PRISMA guidelines (Prospero Registration # CRD42016043718)...
November 7, 2017: Schizophrenia Research
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