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American Journal of Hypertension

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January 5, 2017: American Journal of Hypertension
Stephanie P B Caligiuri, Jose Alejandro Austria, Grant N Pierce
BACKGROUND: Hypertension is a major cause of mortality and morbidity today. The "silent" nature of hypertension makes it critical to determine its prevalence and its severity in the general public and to identify strategies to identify people unaware of its presence. A mobile hypertension awareness campaign was created to: (i) determine the prevalence and types of hypertension in an urban North American center, (ii) increase hypertension awareness, and (iii) identify reasons for lack of therapy adherence...
January 5, 2017: American Journal of Hypertension
Raj Padwal, Norm R C Campbell
No abstract text is available yet for this article.
January 5, 2017: American Journal of Hypertension
Erika S Jones, J David Spence, Adam D Mcintyre, Justus Nondi, Kennedy Gogo, Adeseye Akintunde, Daniel G Hackam, Brian L Rayner
OBJECTIVES: Black subjects tend to retain salt and water, be more sensitive to aldosterone, and have suppression of plasma renin activity. Variants of the renal sodium channel (ENaC, SCNN1B) account for approximately 6% of resistant hypertension (RHT) in Blacks; other candidate genes may be important. METHODS: Six candidate genes associated with low renin-resistant hypertension were sequenced in Black Africans from clinics in Kenya and South Africa. CYP11B2 was sequenced if the aldosterone level was high (primary aldosteronism phenotype); SCNN1B, NEDD4L, GRK4, UMOD, and NPPA genes were sequenced if the aldosterone level was low (Liddle phenotype)...
January 4, 2017: American Journal of Hypertension
Jan A Staessen, Yan Li, Azusa Hara, Kei Asayama, Eamon Dolan, Eoin O'Brien
The rational management of hypertension (HT) inevitably starts with accurate measurement of blood pressure (BP). The recently published Systolic Blood Pressure Intervention Trial implemented automated office BP measurement. However, event-driven studies have overwhelmingly indicated that out-of-the-office BP monitoring is a prerequisite for risk stratification and for identifying the need of initiating or adjusting antihypertensive drug treatment. 24-Hour ambulatory BP monitoring is the preferred method of BP measurement and addresses major issues not covered by conventional or automated office BP measurement or home BP monitoring, such as reliably diagnosing nocturnal HT (the time window of the day during which BP is most predictive of adverse cardiovascular outcome), hypotension, or masked HT, a condition that affects 15% of the general populations and carries a risk equal to that of HT on both office and out-of-the-office BP measurement...
January 4, 2017: American Journal of Hypertension
SeongIl Choi, Jinho Shin, Sung Yong Choi, Ki Chul Sung, Sang Hyun Ihm, Kwang-Il Kim, Yu-Mi Kim
BACKGROUND: Despite an association between visit-to-visit blood pressure (BP) variability (VV-BPV) and cardiovascular (CV) outcomes, many studies performed during the past 4 years have shown conflicting results. This study investigated the impact of VV-BPV on CV outcomes in the Korean National Health Insurance Service (NHIS) database-National Sample Cohort. METHODS: From the 2002 Korean NHIS database (n = 47,851,928), sample subjects with 3 or more BP measurements (n = 51,811) were divided into 2 groups according to a 10 mm Hg cutoff in the SD of systolic BP (SD-SBP)...
January 3, 2017: American Journal of Hypertension
Michel E Safar
No abstract text is available yet for this article.
January 3, 2017: American Journal of Hypertension
Zhichao Zhou, Vishal R Yadav, Changyan Sun, Bunyen Teng, Jamal S Mustafa
OBJECTIVE: We previously showed that uridine adenosine tetraphosphate (Up4A)-mediated aortic contraction is partly mediated through purinergic P2X1 receptors (P2X1R). It has been reported that the plasma level of Up4A is elevated in hypertensive patients, implying a potential role for Up4A-P2X1R signaling in hypertension. This study investigated the vasoactive effect of Up4A in aortas isolated from angiotensin (Ang) II-infused (21 days) hypertensive mice. METHODS: Blood pressure was measured by tail cuff plethysmography...
December 29, 2016: American Journal of Hypertension
You-Hsiang Chu, Chih-Cherng Lu, Tso-Chou Lin, Mei-Yung Tsou, Yu-Juei Hsu, Shung-Tai Ho, Che-Se Tung, Ching-Jiunn Tseng, Min-Hui Li, Herng-Sheng Lee
BACKGROUND: Water ingestion induces the osmopressor response, which typically presents as increased total peripheral vascular resistance in young healthy subjects. A previous study has suggested that the RBC membrane receptor is involved in osmopressor stress. Recent studies have indicated nitric oxide synthase phosphorylation in RBCs. However, the main process in signaling pathway activation to elicit such a response is unknown. Herein, we hypothesized that hypo-osmotic stress following water ingestion modulates the eNOS/NO pathway, thereby alternating vascular resistance...
December 29, 2016: American Journal of Hypertension
Thomas Weber, Stephanie Parragh, Siegfried Wassertheurer
No abstract text is available yet for this article.
December 28, 2016: American Journal of Hypertension
Enrique Rodilla, Sandrine Millasseau, Jose Antonio Costa, Jose Maria Pascual
BACKGROUND: Arterial stiffness, measured with pulse wave velocity (PWV), is now classified as a marker of target organ damage (TOD) alongside left ventricular hypertrophy and moderately increased albuminuria. Interventional studies on treated hypertensive patients have shown that PWV could be improved. Our aim was to assess changes in arterial stiffness after 1 year of routine clinical practice in never-treated hypertensive patients. PATIENTS AND METHODS: We studied 356 never-treated patients with suspected hypertension...
December 18, 2016: American Journal of Hypertension
Shuko Takeda, Ryuichi Morishita
No abstract text is available yet for this article.
December 8, 2016: American Journal of Hypertension
Mayank Sardana, Izzah Vasim, Swapna Varakantam, Uzma Kewan, Ali Tariq, Maheshwara R Koppula, Amer Ahmed Syed, Melissa Beraun, Nadja E A Drummen, Cees Vermeer, Scott R Akers, Julio A Chirinos
BACKGROUND: Large artery stiffness is increased in diabetes mellitus and causes an excessive pulsatile load to the heart and to the microvasculature. The identification of pathways related to arterial stiffness may provide novel therapeutic targets to ameliorate arterial stiffness in diabetes. Matrix Gla-Protein (MGP) is an inhibitor of vascular calcification. Activation of MGP is vitamin K dependent. We hypothesized that levels of inactive MGP (dephospho-uncarboxylated MGP; dp-ucMGP) are related to arterial stiffness in type 2 diabetes...
December 7, 2016: American Journal of Hypertension
Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Konstantinos Rokkas, Athanassios Angelis, Dimitrios Terentes-Printzios, Zisis Kratiras, Christos Georgakopoulos, Dimitrios Tousoulis
BACKGROUND: We investigated whether central hemodynamics predict major adverse cardiovascular events (MACEs) in erectile dysfunction (ED) patients beyond traditional risk factors. METHODS: MACEs in relation to aortic pressures and augmentation index (AIx) were analyzed in 398 patients (mean age, 56 years) with ED but without established cardiovascular (CV) disease. RESULTS: During the mean follow-up period of 6.5 years, a total of 29 (6.5%) MACEs occurred...
December 7, 2016: American Journal of Hypertension
Hack-Lyoung Kim, Jung Pyo Lee, Jung Nam An, Jin Hyuk Kim, Woo-Hyun Lim, Jae-Bin Seo, Woo-Young Chung, Yoon Kyu Oh, Yon Su Kim, Chun Soo Lim, Joo-Hee Zo, Myung-A Kim, Sang-Hyun Kim
BACKGROUND: Soluble forms of tumor necrosis factor receptors (sTNFRs) are emerging target molecules of inflammatory disease. However, their role in vascular biology is not well known. This study was performed to investigate the association between serum concentrations of sTNFRs and arterial stiffness. METHODS: A total of 117 consecutive patients with suspected coronary artery disease (CAD) (63.6 ± 11.0 years; men, 65%) who were referred for invasive coronary angiography (ICA) were prospectively enrolled...
December 7, 2016: American Journal of Hypertension
Raquel de Deus Mendonça, Aline Cristine Souza Lopes, Adriano Marçal Pimenta, Alfredo Gea, Miguel Angel Martinez-Gonzalez, Maira Bes-Rastrollo
BACKGROUND: Some available evidence suggests that high consumption of ultra-processed foods (UPFs) is associated with a higher risk of obesity. Collectively, this association and the nutritional characteristics of UPFs suggest that UPFs might also be associated with hypertension. METHODS: We prospectively evaluated the relationship between UPF consumption and the risk of hypertension in a prospective Spanish cohort, the Seguimiento Universidad de Navarra project...
December 7, 2016: American Journal of Hypertension
Juha S Perkiömäki, Santeri Nortamo, Antti Ylitalo, Antero Kesäniemi, Olavi Ukkola, Heikki V Huikuri
BACKGROUND: We hypothesized that elevated nighttime systolic ambulatory blood pressure (ABP) yields additional information compared with daytime systolic ABP for the long-term risk of atrial fibrillation (AF) and perhaps should be taken into account in treatment strategies for preventing the increasing burden of AF during aging. METHODS: A total of 903 subjects with or without hypertension aged 40 to 59 years, who were recruited to the Oulu Project Elucidating Risk of Atherosclerosis (OPERA) study, underwent ABP monitoring, thorough clinical examinations and laboratory tests...
November 15, 2016: American Journal of Hypertension
Wei-Ting Wang, Shih-Hsien Sung, Jiun-Jr Wang, Cho-Kai Wu, Lian-Yu Lin, Jia-Chun Lee, Hao-Min Cheng, Chen-Huan Chen
BACKGROUND: Excess pressure integral (XSPI) derived from reservoir-excess pressure analysis is proposed as a novel indicator of cardiovascular dysfunction in hypertensives. Our study investigated the prognostic value of XSPI for stable heart failure (HF) patients. METHODS: In total, 238 subjects (mean age 63 ± 18 years, 111 male), comprising 168 stable HF patients with either reduced (SHF; n = 64) left ventricular (LV) ejection fraction (EF) or isolated diastolic dysfunction (DHF, n = 104), and 70 healthy controls, were enrolled...
November 12, 2016: American Journal of Hypertension
Sante D Pierdomenico, Anna M Pierdomenico, Francesca Coccina, Domenico Lapenna, Ettore Porreca
BACKGROUND: The independent prognostic significance of nondipping and morning surge (MS) of blood pressure (BP) in treated hypertensive patients with controlled ambulatory BP is not yet clear. We investigated the association between the aforesaid ambulatory BP parameters and cardiovascular risk in elderly treated hypertensive patients with normal achieved ambulatory BP. METHODS: The occurrence of a composite end-point (stroke, coronary events, heart failure, and peripheral revascularization) was evaluated in 391 elderly treated hypertensive patients (age range 60-90 years) with controlled ambulatory BP (both daytime BP <135/85 mm Hg and nighttime BP <120/70 mm Hg)...
November 12, 2016: American Journal of Hypertension
Ayodele A Odutayo, Karthik K Tennankore, Connor A Emdin
BACKGROUND: The Systolic Blood Pressure Intervention Trial (SPRINT) and the Heart Outcomes Prevention Evaluation 3 (HOPE-3) trial demonstrated the merits of blood pressure (BP) lowering to reduce cardiovascular events in intermediate to high cardiovascular risk adults. However, the population impact of an absolute risk-based strategy for BP lowering remains unclear. METHODS: We examined 3 treatment thresholds using the National Health and Nutrition Examination Survey...
November 12, 2016: American Journal of Hypertension
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