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American Journal of Hypertension

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https://www.readbyqxmd.com/read/29917063/sodium-intake-is-associated-with-endothelial-damage-biomarkers-and-metabolic-dysregulation
#1
Carmen Campino, Rene Baudrand, Carolina Valdivia, Cristian Carvajal, Andrea Vecchiola, Alejandra Tapia-Castillo, Alejandro Martínez-Aguayo, Hernán Garcia, Lorena García, Fidel Allende, Sandra Solari, Cristóbal Fuentes, Calos F Lagos, Maria Paulina Rojas, Doris Muñoz, Carlos Fardella
Background: Mounting evidence has associated high sodium intake with hypertension, cardiovascular disease and stroke. We investigated whether high sodium intake modulates the parameters of endothelial damage, inflammation and oxidative stress. Methods: We used a cross-sectional study design including 223 Chilean subjects (6.9-65.0 years old). We measured aldosterone, renin activity, cortisol, cortisone, adiponectin, leptin, hs-CRP, IL-6, TNF-alpha, PAI-1, metalloproteinase (MMP)-9 and MMP-2 activity and malondialdehyde (MDA)...
June 16, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29868802/adopting-an-orphan-how-could-grp35-contribute-to-angiotensin-ii-dependent-hypertension
#2
Cameron G McCarthy, Camilla F Wenceslau
No abstract text is available yet for this article.
June 4, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29860426/visit-to-visit-variability-of-blood-pressure-is-associated-with-hospitalization-and-mortality-in-an-unselected-adult-population
#3
Marc D Basson, Marilyn G Klug, Jeffrey E Hostetter, Joshua Wynne
Background: Blood pressure variability has been associated with poor health outcomes in high-risk patients, but its association in more general populations is poorly understood. Methods: We analyzed outcomes from 240,622 otherwise unselected patients who had 10 or more outpatient blood pressure readings recorded over a three-year period and were ages 20 to 100 years. Results: Whether calculated as SD, average change, or greatest change and systolic or diastolic blood pressure, we found that higher outpatient blood pressure variability was associated with subsequent hospitalization and mortality...
May 31, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29860395/the-orphan-receptor-gpr35-contributes-to-angiotensin-ii-induced-hypertension-and-cardiac-dysfunction-in-mice
#4
Nina Divorty, Graeme Milligan, Delyth Graham, Stuart A Nicklin
BACKGROUND: The orphan receptor G protein-coupled receptor 35 (GPR35) has been associated with a range of diseases, including cancer, inflammatory bowel disease, diabetes, hypertension, and heart failure. To assess the potential for GPR35 as a therapeutic target in cardiovascular disease, this study investigated the cardiovascular phenotype of a GPR35 knockout mouse under both basal conditions and following pathophysiological stimulation. METHODS: Blood pressure was monitored in male wild-type and GPR35 knockout mice over 7-14 days using implantable telemetry...
May 31, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29850782/association-between-change-in-central-nocturnal-blood-pressure-and-urine-albumin-creatinine-ratio-by-a-valsartan-amlodipine-combination-a-cpet-study
#5
Takeshi Fujiwara, Yuichiro Yano, Satoshi Hoshide, Hiroshi Kanegae, Junichiro Hashimoto, Kazuomi Kario
BACKGROUND: We aimed to assess the association of changes in brachial or central nocturnal systolic blood pressure (SBP) with change in urine albumin-creatinine ratio (UACR) by a valsartan/amlodipine combination (80/5 mg) therapy in hypertensive patients. METHODS: Twenty-three patients (age range, 47-78 years; mean, 68.0 years; 35% men, 65% with chronic kidney disease) with clinic brachial BP ≥140/90 mm Hg were treated with valsartan/amlodipine combination therapy for 16 weeks...
May 30, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29800045/circulating-micrornas-implicate-multiple-atherogenic-abnormalities-in-the-long-term-cardiovascular-sequelae-of-preeclampsia
#6
Natalie Dayan, Kenny Schlosser, Duncan J Stewart, Christian Delles, Amanpreet Kaur, Louise Pilote
BACKGROUND: Women who have had preeclampsia (PE) are at increased risk for premature cardiovascular disease (CVD). The underlying pathophysiology of this risk remains unclear, but potentially involves subclinical vascular damage or dysfunction. Alterations in the levels of circulating microRNAs may be implicated, as they are known to play pervasive roles in vascular biology. We investigated whether levels of circulating microRNAs are altered between women with premature acute coronary syndrome (ACS), with and without a history of PE...
May 23, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29788212/yogurt-intake-and-risk-of-cardiovascular-disease-among-hypertensive-individuals-is-it-time-for-a-clinical-trial
#7
Merrill F Elias, Alexandra T Wade, Georgina E Crichton
No abstract text is available yet for this article.
May 21, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29788196/maternal-weight-snoring-and-hypertension-potential-pathways-of-associations
#8
Galit Levi Dunietz, Kerby Shedden, Lynda D Lisabeth, Marjorie C Treadwell, Louise M O'Brien
Background: Hypertensive disorders of pregnancy (HDP) are linked to excessive maternal weight and frequent snoring. However, pathways between maternal excessive weight, pregnancy-onset snoring and HDP are only partially estimated. We examined and quantified the total and direct associations between excessive maternal weight and incident HDP and their indirect pathway through pregnancy-onset snoring. Methods: Third trimester pregnant women enrolled from prenatal clinics of a large tertiary medical center...
May 18, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29788130/patient-barriers-and-facilitators-to-ambulatory-and-home-blood-pressure-monitoring-a-qualitative-study
#9
Eileen J Carter, Nathalie Moise, Carmela Alcántara, Alexandra M Sullivan, Ian M Kronish
BACKGROUND: Guidelines recommend that patients with newly elevated office blood pressure undergo ambulatory blood pressure monitoring (ABPM) or home blood pressure monitoring (HBPM) to rule-out white coat hypertension before being diagnosed with hypertension. We explored patients' perspectives of the barriers and facilitators to undergoing ABPM or HBPM. METHODS: Focus groups were conducted with twenty English- and Spanish-speaking individuals from underserved communities in New York City...
May 18, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29788246/hypertension-induced-morphological-and-physiological-changes-in-cells-of-the-arterial-wall
#10
P A Martinez-Quinones, C G McCarthy, S W Watts, N Klee, A Komic, F Calmasini, F Priviero, A Warner, Y Chenghao, C F Wenceslau
Morphological and physiological changes in the vasculature have been described in the evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction may present itself as a contributing, or consequential factor, to vascular remodeling caused by chronically elevated systemic arterial blood pressure. Changes in all vessel layers, from the endothelium to the perivascular adipose tissue, have been described. This mini-review focuses on the current knowledge of the structure and function of the vessel layers, specifically muscular arteries: intima, media, adventitia, perivascular adipose tissue, and the cell types harbored within each vessel layer...
May 17, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29788226/circulating-dp-ucmgp-is-associated-with-kidney-dysfunction-and-arterial-stiffness
#11
Houry Puzantian, Scott R Akers, Garrett Oldland, Khuzaima Javaid, Rachana Miller, Yueya Ge, Bilal Ansari, Jonathan Lee, Arpita Suri, Zeba Hasmath, Raymond Townsend, Julio A Chirinos
Background: Large artery stiffening is increased in advanced CKD, but likely develops progressively in earlier stages of CKD. Active matrix Gla-Protein (MGP) is a potent vitamin-K dependent inhibitor of vascular calcification. A recent animal model demonstrated intrinsic abnormalities in vitamin K metabolism even in early CKD, but whether early human CKD is associated with vascular vitamin K deficiency is unknown. Methods: We enrolled 137 adults without HF with varying degrees of renal function: normal eGFR (>90 mL/min; n=59), mildly reduced eGFR (stage 2 CKD: eGFR = 60-89 mL/min; n=53) or at least moderately reduced eGFR (stage 3-5 CKD; eGFR<60 ml/min; n=25)...
May 17, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29788148/the-role-of-angiogenesis-inhibitors-in-hypertension-following-ariadne-s-thread
#12
Elias Sanidas, Dimitris P Papadopoulos, Maria Velliou, Kostas Tsioufis, Marina Mantzourani, Dimitris Iliopoulos, Despoina Perrea, John Barbetseas, Vasilios Papademetriou
Arterial hypertension (HT) is one of the most frequently recorded comorbidities among patients under antiangiogenic therapy. Inhibitors of vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFR) are most commonly involved in new onset or exacerbation of pre-existing controlled HT. From the pathophysiology point of view, data support that reduced nitric oxide release and sodium and fluid retention, microvascular rarefaction, elevated vasoconstrictor levels and globular injury might contribute to HT...
May 17, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29788034/sleep-disorders-including-sleep-apnea-and-hypertension
#13
E M Van Ryswyk, S Mukherjee, C L Chai-Coetzer, A Vakulin, R D McEvoy
There is mounting evidence for an association between sleep disorders and hypertension. In obstructive sleep apnea (OSA) there are plausible biological reasons for the development of hypertension, and treatment of OSA results in modest (2-3 mmHg), adherence-dependent decreases in blood pressure (BP), with larger effects evident in those with resistant hypertension. However, prospective, population-based cohort studies have not yet convincingly demonstrated a link between OSA and incident hypertension, and adequately powered controlled trials of CPAP for the prevention or treatment or hypertension are lacking...
May 17, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29767674/optimal-blood-pressure-in-elderly-hypertensive-subjects-a-korean-national-health-insurance-service-health-examinee-cohort-study
#14
Jiwon Seo, Chan Joo Lee, Jinseub Hwang, Jaewon Oh, Sang-Hak Lee, Seok-Min Kang, Donghoon Choi, Hyeon-Chang Kim, Sungha Park
Background: To describe the association between mean blood pressure (BP) and clinical outcomes and to investigate the optimal BP in elderly hypertensive subjects. Methods: This study used the National Health Insurance Service health examinee sample cohort. Subjects aged >60 years with a new diagnosis of hypertension from 2003 to 2006 were selected. Patients with previous major cardiovascular events were excluded. The remaining 23,523 subjects were divided into 3 groups according to mean systolic BP (SBP) and diastolic BP (DBP): average SBP <130 mmHg (n=6,893), 130-140 mmHg (n=8,676), and ≥140 mmHg (n=7,954) or 2) average DBP <80 mmHg (n=9,273), 80-90 mmHg (n=11,607), and ≥90 mmHg (n=2,643)...
May 15, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29767672/blockade-of-tlr4-within-the-paraventricular-nucleus-attenuates-blood-pressure-by-regulating-ros-and-inflammatory-cytokines-in-prehypertensive-rats
#15
Mo-Lin Wang, Xiao-Jing Yu, Xiao-Guang Li, De-Zhi Pang, Qing Su, Roland Osei Saahene, Hong-Bao Li, Xu-Ying Mao, Kai-Li Liu, Li-Yan Fu, Ying Li, Guo-Qing Zhu, Yu-Ming Kang
Background: Toll like receptor 4 (TLR4) has been implicated in the progression of cardiovascular disease, including hypertension. However, the role of TLR4 in the development of prehypertension is uncertain. Methods: Prehypertensive rats were treated with 8% salt for 12 weeks to induce prehypertension. These rats were then given either TAK-242 selective TLR4 blocker, or vehicle by bilateral micro-injection to the paraventricular nucleus (PVN). Blood pressure and renal sympathetic nerve activity were recorded...
May 15, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29767671/significance-of-an-increase-in-diastolic-blood-pressure-during-a-stress-test-in-terms-of-comorbidities-and-long-term-total-and-cv-mortality
#16
Nóra Sydó, Tibor Sydó, Karina A Gonzalez Carta, Nasir Hussain, Béla Merkely, Joseph G Murphy, Ray W Squires, Francisco Lopez-Jimenez, Thomas G Allison
Background: A decrease in diastolic blood pressure (DBP) with exercise is considered normal, but the significance of an increase in DBP has not been validated. Our aim was to determine the relationship of DBP increasing on a stress test regarding comorbidities and mortality. Methods: Our database was reviewed from 1993-2010 using the first stress test of a patient. Non-Minnesota residence, baseline CV disease, rest DBP <60 or >100 mmHg, and age <30 or ≥80 were exclusion criteria...
May 15, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29746623/is-it-the-forward-wave-pressure-that-matters
#17
Marc L De Buyzere, Ernst R Rietzschel
No abstract text is available yet for this article.
May 9, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29741563/erratum
#18
(no author information available yet)
No abstract text is available yet for this article.
May 8, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29733344/impact-of-blunted-nocturnal-blood-pressure-dipping-on-cardiac-systolic-function-in-community-participants-not-receiving-anti-hypertensive-therapy
#19
Angela J Woodiwiss, Carlos D Libhaber, Pinhas Sareli, Gavin R Norton
Background: Blunted nocturnal blood pressure (BP) dipping (non-dipping) predicts cardiovascular morbidity and mortality, and is associated with heart failure (HF) independent of office BP. Whether non-dipping is independently associated with cardiac systolic function prior to the development of HF is uncertain. Methods: We assessed whether nocturnal BP dipping pattern and nocturnal BP were associated with indexes of cardiac systolic function [endocardial fractional shortening (endFS), midwallFS (mFS), ejection fraction (EF)] independent of left ventricular mass index (LVMI) and relative wall thickness (RWT) in 491 randomly selected community participants not receiving anti-hypertensive therapy...
May 4, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29722788/renal-protective-effects-of-n-acetyl-seryl-aspartyl-lysyl-proline-ac-sdkp-in-obese-rats-on-a-high-salt-diet
#20
Mani Maheshwari, Cesar A Romero, Sumit R Monu, Nitin Kumar, Tang-Dong Liao, Edward L Peterson, Oscar A Carretero
BACKGROUND: Obesity is a public health problem, associated with salt sensitive hypertension, kidney inflammation, and fibrosis. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a tetra peptide with anti-inflammatory and anti-fibrotic properties. However, its effect on preventing kidney damage in obesity is unknown. We hypothesized that Zucker obese (ZO) rats on a high-salt (HS) diet develop renal damage, inflammation, fibrosis, and this is prevented with Ac-SDKP treatment. METHODS: Zucker lean (ZL) and ZO rats (8 weeks old) were treated with Ac-SDKP (1...
May 2, 2018: American Journal of Hypertension
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