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American Journal of Hypertension

Juha S Perkiömäki, Santeri Nortamo, Antti Ylitalo, Antero Kesäniemi, Olavi Ukkola, Heikki V Huikuri
BACKGROUND: We hypothesized that elevated nighttime systolic ambulatory blood pressure (ABP) yields additional information compared with daytime systolic ABP for the long-term risk of atrial fibrillation (AF) and perhaps should be taken into account in treatment strategies for preventing the increasing burden of AF during aging. METHODS: A total of 903 subjects with or without hypertension aged 40 to 59 years, who were recruited to the Oulu Project Elucidating Risk of Atherosclerosis (OPERA) study, underwent ABP monitoring, thorough clinical examinations and laboratory tests...
November 15, 2016: American Journal of Hypertension
Wei-Ting Wang, Shih-Hsien Sung, Jiun-Jr Wang, Cho-Kai Wu, Lian-Yu Lin, Jia-Chun Lee, Hao-Min Cheng, Chen-Huan Chen
BACKGROUND: Excess pressure integral (XSPI) derived from reservoir-excess pressure analysis is proposed as a novel indicator of cardiovascular dysfunction in hypertensives. Our study investigated the prognostic value of XSPI for stable heart failure (HF) patients. METHODS: In total, 238 subjects (mean age 63 ± 18 years, 111 male), comprising 168 stable HF patients with either reduced (SHF; n = 64) left ventricular (LV) ejection fraction (EF) or isolated diastolic dysfunction (DHF, n = 104), and 70 healthy controls, were enrolled...
November 12, 2016: American Journal of Hypertension
Tanja Dudenbostel, David A Calhoun
No abstract text is available yet for this article.
November 12, 2016: American Journal of Hypertension
Sante D Pierdomenico, Anna M Pierdomenico, Francesca Coccina, Domenico Lapenna, Ettore Porreca
BACKGROUND: The independent prognostic significance of nondipping and morning surge (MS) of blood pressure (BP) in treated hypertensive patients with controlled ambulatory BP is not yet clear. We investigated the association between the aforesaid ambulatory BP parameters and cardiovascular risk in elderly treated hypertensive patients with normal achieved ambulatory BP. METHODS: The occurrence of a composite end-point (stroke, coronary events, heart failure, and peripheral revascularization) was evaluated in 391 elderly treated hypertensive patients (age range 60-90 years) with controlled ambulatory BP (both daytime BP <135/85 mm Hg and nighttime BP <120/70 mm Hg)...
November 12, 2016: American Journal of Hypertension
Ayodele A Odutayo, Karthik K Tennankore, Connor A Emdin
BACKGROUND: The Systolic Blood Pressure Intervention Trial (SPRINT) and the Heart Outcomes Prevention Evaluation 3 (HOPE-3) trial demonstrated the merits of blood pressure (BP) lowering to reduce cardiovascular events in intermediate to high cardiovascular risk adults. However, the population impact of an absolute risk-based strategy for BP lowering remains unclear. METHODS: We examined 3 treatment thresholds using the National Health and Nutrition Examination Survey...
November 12, 2016: American Journal of Hypertension
Luke J Laffin, George L Bakris
The year 2014 was a turning point for the field of renal denervation (RDN) and its potential use to treat resistant hypertension. Tremendous enthusiasm shifted to sober reflection on the efficacy of a technology once touted as the cure to resistant hypertension. The following review highlights 2 major questions: First, does catheter-based RDN lower blood pressure and, second, will RDN using catheter-directed therapy for the treatment of resistant hypertension ever become more than an investigational technology...
November 12, 2016: American Journal of Hypertension
Ciarán Finucane, Rose Anne Kenny
No abstract text is available yet for this article.
November 9, 2016: American Journal of Hypertension
Laiyuan Wang, Hongfan Li, Bin Yang, Liwei Guo, Xikun Han, Lin Li, Mengting Li, Jianfeng Huang, Dongfeng Gu
BACKGROUND: The large-scale meta-analysis of genome-wide association study (GWAS) recently identified a genomic locus where the genetic variant at rs820430 was strongly associated with hypertension in Chinese Han population, with its T allele conferred increased risks. However, the biological and disease-relevant mechanisms for this association remain elusive. METHODS: A group of 275 participants from rural district of Shandong Province were enrolled, rs820430 was genotyped using genomic DNA with the fluorogenic 5'-nuclease TaqMan allelic discrimination assay system (Applied Biosystems, CA)...
October 25, 2016: American Journal of Hypertension
Satoshi Konno, Masanori Munakata
BACKGROUND: We have previously reported that the public employees of Watari town showed significantly greater elevations in both systolic and diastolic blood pressure than the general population 4-8 months after the Great East Japan Earthquake, which occurred on 11 March 2011. To examine whether these differences persisted thereafter, we conducted a follow-up study for both the public employees and the general population of Watari town over 1 year. METHODS: Among 225 public employees and 1232 individuals from the general population of the town who received consecutive annual health checkups from 2010 to 2012, 89 pairs were matched for age and sex according to a propensity score...
October 25, 2016: American Journal of Hypertension
Madhu V Singh
No abstract text is available yet for this article.
October 4, 2016: American Journal of Hypertension
Chong-Fu Jia, Yi-Nong Jiang, Zhi-Qiang Yang, Xi-Xia Sun, Yang Yu, Hao Wang, Yan Lu, Ai-Jun Chen, Zhao-Qian Wang
BACKGROUND: A new feature of coronary computed tomography angiography (CTA) is to estimate ascending aortic elasticity without additional cost, but its applicable benefit for prehypertension patients is still unclear. The aim of this study is to discuss the characteristic of ascending aortic elasticity for specific prehypertension patients and its risk factors. METHODS: Coronary CTA examinations of 398 participants were performed using a 128 slicer CT scanner. The differences of 3 ascending aortic elasticity related indices, including aortic distensibility (AD), aortic compliance (AC), and aortic stiffness (ASI), and anatomical measurements were analyzed among the normal, prehypertension, and primary hypertension groups...
September 29, 2016: American Journal of Hypertension
Yuichiro Yano
No abstract text is available yet for this article.
September 29, 2016: American Journal of Hypertension
Robert M Carey
The renin-angiotensin system (RAS) is arguably the most important and best studied hormonal system in the control of blood pressure (BP) and the pathogenesis of hypertension. The RAS features its main effector angiotensin II (Ang II) acting via its 2 major receptors, angiotensin type-1(AT1R) and type-2 (AT2R). In general, AT2Rs oppose the detrimental actions of Ang II via AT1Rs. AT2R activation induces vasodilation and natriuresis, but its effects to lower BP in hypertension have not been as clear as anticipated...
September 24, 2016: American Journal of Hypertension
Dingding Zhang, Dongfeng Gu, Jiang He, James E Hixson, Dabeeru C Rao, Changwei Li, Hua He, Jichun Chen, Jianfeng Huang, Jing Chen, Treva K Rice, Shufeng Chen, Tanika N Kelly
BACKGROUND: Single-marker and novel gene-based methods were employed to examine the associations of the serum/glucocorticoid regulated kinases (SGK) gene family with longitudinal blood pressure (BP) changes and hypertension incidence in a family-based cohort study. METHODS: Totally, 1,768 Chinese participants from the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) follow-up study were included in the current analyses. Nine BP measures were obtained at each of 3 visits during the GenSalt follow-up study...
September 24, 2016: American Journal of Hypertension
Carmine Savoia
No abstract text is available yet for this article.
September 22, 2016: American Journal of Hypertension
Panagiotis I Georgianos, Rajiv Agarwal
Contrary to the direct, graded, and causal relationship of hypertension with cardiovascular outcomes in the general population, among dialysis patients, blood pressure (BP) recorded either predialysis or postdialysis displays a U-shaped curve with mortality. This paradoxical phenomenon of lower BP or a decline in BP over time being associated with increased mortality and higher BP being associated with a lower mortality is described as "reverse" epidemiology of hypertension, raising substantial controversy on whether BP lowering causes harms or benefits among dialysis patients...
September 22, 2016: American Journal of Hypertension
Lina Bergman, Helena Åkerud, Anna Karin Wikström, Marita Larsson, Tord Naessen, Tansim Akhter
BACKGROUND: There is evidence of cerebral involvement among women with preeclampsia. Levels of the cerebral biomarkers neuron-specific enolase (NSE) and S100B are elevated during pregnancy in women developing preeclampsia. It is although not known if these biomarkers return to normal range postpartum. The aim with this study was to compare levels of S100B and NSE during pregnancy and 1 year postpartum in women who have had preeclampsia to women with normal pregnancies. METHODS: This study was a longitudinal study of cases (n = 53) with preeclampsia and controls (n = 58) consisted of normal pregnant women in matched gestational weeks...
September 21, 2016: American Journal of Hypertension
Carolina De Ciuceis, Claudia Rossini, Paolo Airò, Mirko Scarsi, Angela Tincani, Guido Alberto Massimo Tiberio, Silvia Piantoni, Enzo Porteri, Leonardo Solaini, Sarah Duse, Francesco Semeraro, Beatrice Petroboni, Luigi Mori, Maurizio Castellano, Alice Gavazzi, Claudia Agabiti Rosei, Enrico Agabiti Rosei, Damiano Rizzoni
BACKGROUND: Different components of the immune system, including innate and adaptive immunity (T-effector lymphocytes and T-regulatory lymphocytes-TREGs) may be involved in the development of hypertension. In addition, it was demonstrated in animal models that TREGs may prevent angiotensin II-induced hypertension and vascular injury/inflammation. However, no data are presently available in humans about possible relationships between T-lymphocyte subtypes and microvascular structural alterations...
September 21, 2016: American Journal of Hypertension
Alejandro de la Sierra, Julia Pareja, Pedro Armario, Ángela Barrera, Sergi Yun, Susana Vázquez, Laia Sans, Julio Pascual, Anna Oliveras
BACKGROUND: Sympathetic renal denervation (SRD) has been proposed as a therapeutic alternative for patients with resistant hypertension not controlled on pharmacological therapy. Two studies have suggested an effect of SRD in reducing short-term blood pressure variability (BPV). However, this has not been addressed in a randomized comparative trial. We aimed to compare the effects of spironolactone and SRD on circadian BP and BPV. METHODS: This is a post-hoc analysis of a randomized trial in 24 true resistant hypertensive patients (15 men, 9 women; mean age 64 years) comparing 50mg of spironolactone (n = 13) vs...
September 20, 2016: American Journal of Hypertension
Stephen P Juraschek, Natalie Daya, Lawrence J Appel, Edgar R Miller, Beverly Gwen Windham, Lisa Pompeii, Michael E Griswold, Anna Kucharska-Newton, Elizabeth Selvin
BACKGROUND: One-third of older adults fall each year. Orthostatic hypotension (OH) has been hypothesized as an important risk factor for falls, but findings from prior studies have been inconsistent. METHODS: We conducted a prospective study of the association between baseline OH (1987-1989) and risk of falls in the Atherosclerosis Risk in Communities (ARIC) Study. Falls were ascertained during follow-up via ICD-9 hospital discharge codes or Centers for Medicare & Medicaid Services claims data...
September 16, 2016: American Journal of Hypertension
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