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American Journal of Hypertension

Brian Czaya, Wacharee Seeherunvong, Saurav Singh, Christopher Yanucil, Phillip Ruiz, Yasmir Quiroz, Alexander Grabner, Chryso Katsoufis, Sethuraman Swaminathan, Carolyn Abitbol, Bernardo Rodriguez-Iturbe, Christian Faul, Michael Freundlich
Background: In uremic animals, vitamin D receptor (VDR) agonists like paricalcitol (Pc) attenuate cardiac hypertrophy, but this effect has not been replicated consistently in humans with chronic kidney disease. Elevated fibroblast growth factor 23 (FGF23) levels cause cardiac hypertrophy with activation of the myocardial calcineurin/nuclear factor of activated T cell (NFAT) axis and may antagonize the cardioprotective effects of VDR agonist therapy. We hypothesized that the effectiveness of Pc may depend on the prevailing circulating levels of FGF23 and could be potentiated by the combined administration of a pan-FGF23 receptor (FGFR) blocker agent (PD173074)...
October 17, 2018: American Journal of Hypertension
Nuria Garcia-Fernandez, Javier Lavilla, Paloma L Martín, Gregorio Romero-González, Arantxa González, Begoña López, Susana Ravassa, Javier Díez
No abstract text is available yet for this article.
October 16, 2018: American Journal of Hypertension
Marie-Ève Leblanc, Audrey Auclair, Jacinthe Leclerc, Jean Bussières, Mohsen Agharazii, Frédéric-Simon Hould, Simon Marceau, Patrice Brassard, Christian Godbout, Audrey Grenier, Lyne Cloutier, Paul Poirier
Background: Blood pressure measurement in severe obesity may be technically challenging as the cuff of the device may not fit adequately around the upper arm. The aim of the study was to assess the agreement between intra-arterial blood pressure values (gold standard) compared with forearm blood pressure measurements in severely obese patients in different arm positions. Methods: Thirty-three severely obese patients and 21 controls participated in the study. Pairs of intra-arterial blood pressures were compared with simultaneous forearm blood pressure measurement using an oscillometric device in 4 positions: (i) supine, (ii) semi-fowler with the forearm resting at heart level, (iii) semi-fowler with the arm downward, and (iv) semi-fowler with the arm raised overhead...
October 12, 2018: American Journal of Hypertension
Lindsey A Ramirez, Jennifer C Sullivan
While it has been known since the 1940's that men have greater increases in blood pressure compared to women, there have been intense efforts more recently to increase awareness that women are also at risk for developing hypertension, and that cardiovascular diseases are the leading causes of death among both men and women in the US. With the release of the 2017 Hypertension Clinical Guidelines, 46% of adults in the US are now classified as hypertensive and hypertension is the primary modifiable risk factor for the development of cardiovascular disease...
October 9, 2018: American Journal of Hypertension
Pierre Boutouyrie, Rosa-Maria Bruno
Increasing evidence points out at vascular stiffness (and in particular aortic stiffness measured by pulse wave velocity) as a reliable biomarker of vascular aging, able to integrate in a single measure the overall burden of cardiovascular (CV) risk factors on the vasculature over time; furthermore, it may be per se a mechanism of disease, by inducing microcirculatory damage and favoring CV events. Increased aortic stiffness has been shown to predict future CV events and improve risk reclassification in those at intermediate risk...
October 5, 2018: American Journal of Hypertension
Carmen Campino, Rene Baudrand, Carlos E Fardella
No abstract text is available yet for this article.
October 5, 2018: American Journal of Hypertension
Asako Namai-Takahashi, Akihiro Sakuyama, Takahiro Nakamura, Takahiro Miura, Junta Takahashi, Ryo Kurosawa, Masahiro Kohzuki, Osamu Ito
BACKGROUND: Xanthine oxidase (XO) is a source of reactive oxygen species production in the heart. However, pathophysiological role of XO has not been clarified in hypertensive heart disease. Thus, the present study examined impacts of high salt (HS) intake and febuxostat (Fx), a XO inhibitor in Dahl salt-sensitive (Dahl-S) rats. METHODS: 8-week old, male Dahl-S rats were fed a normal salt diet (0.6% NaCl) or a HS diet (8% NaCl) for 8 weeks. A part of the rats fed the HS diet were simultaneously treated with Fx (3mg/kg/day)...
October 1, 2018: American Journal of Hypertension
Masashi Tawa, Yoko Yano, Misaki Yamanaka, Tatsuya Sawano, Kana Iesaki, Yuka Murata, Ryosuke Tanaka, Keisuke Nakagawa, Mamoru Ohkita, Yasuo Matsumura
BACKGROUND: Recently, attention has been focused on the cardiovascular protective effects of beet juice (BJ) with high amounts of nitrate. In this study, we examined the effect of BJ supplementation in a rat model of monocrotaline (MCT)-induced pulmonary hypertension (PH). METHODS: MCT (60 mg/kg) was subcutaneously administered to rats, and BJ (prepared by dissolving BJ powder at a concentration of 1 g/L or 10 g/L in drinking water) supplementation was started from the day of, 1 week before, and 2 weeks after MCT injection...
September 28, 2018: American Journal of Hypertension
(no author information available yet)
No abstract text is available yet for this article.
September 28, 2018: American Journal of Hypertension
Yasuharu Tabara, Mitsuhiro Masaki, Tome Ikezoe, Kazuya Setoh, Takehiro Kato, Takahisa Kawaguchi, Shinji Kosugi, Takeo Nakayama, Noriaki Ichihashi, Tadao Tsuboyama, Fumihiko Matsuda
BACKGROUND: Orthostatic hypertension was associated with worse cardiovascular outcomes, although the factors responsible for an orthostatic rise in blood pressure (BP) are uncertain. We investigated a possible relationship between a stooping posture and orthostatic BP change. METHODS: Study participants consisted of 1,992 older individuals. Orthostatic BP change was calculated by systolic BP measured at sitting position, and again 1 and 3 minutes after standing up...
September 27, 2018: American Journal of Hypertension
Ehimare Akhabue, Thanh-Huyen T Vu, Anand Vaidya, Erin D Michos, Ian H de Boer, Bryan Kestenbaum, Matthew Allison, Moyses Szklo, Pamela Ouyang, Clyde W Yancy, Myles Wolf, Tamara Isakova, Mercedes R Carnethon
Background: Higher Fibroblast Growth Factor-23 (FGF23) concentrations have been found to be associated with incident heart failure (HF). Experimental data suggest FGF23 directly stimulates myocardial hypertrophy. FGF23 may also enhance renin-angiotensin-aldosterone system activity. Whether FGF23 is associated with increased HF risk in populations with hypertension and whether this association is weaker in the presence of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) therapy is unknown...
September 25, 2018: American Journal of Hypertension
Kazushi Tsuda
No abstract text is available yet for this article.
September 25, 2018: American Journal of Hypertension
(no author information available yet)
No abstract text is available yet for this article.
September 21, 2018: American Journal of Hypertension
Yasuharu Tabara, Takeshi Matsumoto, Kimihiko Murase, Kazuya Setoh, Takahisa Kawaguchi, Shunsuke Nagashima, Shinji Kosugi, Takeo Nakayama, Tomoko Wakamura, Toyohiro Hirai, Kazuo Chin, Fumihiko Matsuda
BACKGROUND: The aim of this study is to clarify associations between orthostatic blood pressure (BP) change, as well as possible physiological factors, and day-to-day home BP variability, a promising risk factor for cardiovascular outcomes. METHODS: Study participants were 6,465 community residents (age 58.3 years). Home BP was measured every morning and evening for 7 days. Orthostatic BP was calculated as the maximum difference between BP measured while sitting and remeasured after 1 and 3 minutes standing...
September 19, 2018: American Journal of Hypertension
A Sherwood, L K Hill, J A Blumenthal, A L Hinderliter
Background: The non-dipping circadian blood pressure (BP) profile is associated with both poor sleep quality and increased cardiovascular risk. The present study aimed to clarify the potential confounding effects of 24-hour ambulatory blood pressure monitoring (ABPM) used to characterize the circadian BP profile by assessing its impact on sleep quality. Methods: Participants were 121 middle-aged men and women with untreated hypertension (age=46±8 years; 43% women; 45% African American)...
September 11, 2018: American Journal of Hypertension
Lisa M Walter
No abstract text is available yet for this article.
September 8, 2018: American Journal of Hypertension
Antonios A Argyris, Thomas Weber, Athanase D Protogerou
No abstract text is available yet for this article.
September 6, 2018: American Journal of Hypertension
Giuliano Tocci, Vivianne Presta, Ilaria Figliuzzi, Francesca Miceli, Barbara Citoni, Roberta Coluccia, Anna Paini, Massimo Salvetti, Andrea Ferrucci, Maria Lorenza Muiesan, Massimo Volpe
Background: United States (US) guidelines on high blood pressure (BP) have recently proposed a new BP stratification. Objective: To evaluate the redistribution of adult outpatients according to 2003 and 2017 US hypertension guidelines. Methods: We extracted data referred to individuals aged between 40-70 years with valid BP assessment from a national, cross-sectional database. The following systolic/diastolic BP strata were considered: a) 2003 guidelines: 0=normal (<120/180 mmHg); 1=prehypertension (≥120 and ≤139/≥80 and ≤89 mmHg); 2=stage 1 (≥140 and ≤159/≥90 and ≤99 mmHg); 3=stage 2 (≥160/≥100 mmHg); b) 2017 ACC/AHA guidelines: 0=normal (<120/80 mmHg); 1=elevated (≥120 and ≤129/<80 mmHg); 2=stage 1 (≥130 and ≤139/≥80 and ≤89 mmHg); 3=stage 2 (≥140/≥90 mmHg)...
September 5, 2018: American Journal of Hypertension
A A Divney, S E Echeverria, L E Thorpe, C Trinh-Shevrin, N S Islam
No abstract text is available yet for this article.
August 25, 2018: American Journal of Hypertension
Robert E Olivo, Sarah L Hale, Clarissa J Diamantidis, Nrupen A Bhavsar, Crystal C Tyson, Katherine L Tucker, Teresa C Carithers, Bryan Kestenbaum, Paul Muntner, Rikki M Tanner, John N Booth, Stanford E Mwasongwe, Jane Pendergast, L Ebony Boulware, Julia J Scialla
Background: Higher dietary phosphorus is associated with left ventricular hypertrophy and mortality, which are blood pressure (BP)-related outcomes. For this reason, we hypothesized that dietary phosphorus may be associated with adverse clinic and ambulatory BP patterns. Methods: Our study included 973 African-American adults enrolled in the Jackson Heart Study (2000-2004) with 24-hour ambulatory BP monitoring (ABPM) data at baseline. We quantified dietary phosphorus from a validated food frequency questionnaire (FFQ) as the following: 1) absolute daily intake, 2) ratio of phosphorus-to-protein intake, 3) phosphorus density, and 4) energy-adjusted phosphorus intake...
August 10, 2018: American Journal of Hypertension
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