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American Journal of Hypertension

Robert E Olivo, Sarah L Hale, Clarissa J Diamantidis, Nrupen A Bhavsar, Crystal C Tyson, Katherine L Tucker, Teresa C Carithers, Bryan Kestenbaum, Paul Muntner, Rikki M Tanner, John N Booth, Stanford E Mwasongwe, Jane Pendergast, L Ebony Boulware, Julia J Scialla
Background: Higher dietary phosphorus is associated with left ventricular hypertrophy and mortality, which are blood pressure (BP)-related outcomes. For this reason, we hypothesized that dietary phosphorus may be associated with adverse clinic and ambulatory BP patterns. Methods: Our study included 973 African-American adults enrolled in the Jackson Heart Study (2000-2004) with 24-hour ambulatory BP monitoring (ABPM) data at baseline. We quantified dietary phosphorus from a validated food frequency questionnaire (FFQ) as the following: 1) absolute daily intake, 2) ratio of phosphorus-to-protein intake, 3) phosphorus density, and 4) energy-adjusted phosphorus intake...
August 10, 2018: American Journal of Hypertension
Michelle M Harbin, Neil E Hultgren, Aaron S Kelly, Donald R Dengel, Nicholas G Evanoff, Justin R Ryder
Background: The relationship of pediatric severe obesity (SO) and central aortic blood pressure (BP) has yet to be established. Methods: We conducted a cross-sectional study of 348 youth (48.5% male, 12.7±0.1 years) with a wide range of body mass index (BMI) values: normal weight (NW; 5th and <85th BMI percentile); overweight/obesity (OW/OB; 85th to <120% of the 95th BMI percentile); and SO (≥120% of the 95th BMI percentile). Measures of central aortic blood pressure were obtained via applanation tonometry with SphygmoCor MM3 software...
August 9, 2018: American Journal of Hypertension
Xin Zhang, Seo Rin Kim, Christopher M Ferguson, Behzad Ebrahimi, Ahmad F Hedayat, Amir Lerman, Lilach O Lerman
Background: The collateral circulation is important in maintenance of blood supply to the ischemic kidney distal to renal artery stenosis (RAS). Obesity-metabolic syndrome (MetS) preserves renal blood flow (RBF) in the stenotic kidney, but whether this is related to an increase of collateral vessel growth is unknown. We hypothesized that MetS increased collateral circulation around the renal artery. Methods: Twenty-one domestic pigs were randomly divided into unilateral RAS fed an atherogenic (high-fat/high-fructose, MetS-RAS) or standard diet, or controls (n=7 each)...
August 9, 2018: American Journal of Hypertension
Pedro Blanch, Pedro Armario, Anna Oliveras, Patricia Fernández-Llama, Susana Vázquez, Julia Pareja, Empar Álvarez, Francesca Calero, Cristina Sierra, Alejandro de la Sierra
Background: Central blood pressure (BP) is considered as a better estimator of hypertension associated risks than peripheral BP. We aimed to evaluate the association of 24-hour central BP, in comparison with 24-hour peripheral BP, with the presence of left ventricular hypertrophy (LVH), or diastolic dysfunction (DD). Methods: Cross-sectional study of 208 hypertensive patients, aged 57±12 years, 34% women. Office and 24-hour central and peripheral BP were measured by the oscillometric Mobil-O-Graph device...
August 1, 2018: American Journal of Hypertension
Sudhir Jain, Anita Rana, Kavita Jain, Sravan K Perla, Nitin Puri, Ashok Kumar
Background: The contribution of single nucleotide polymorphisms in transcriptional regulation of the human angiotensin receptor type I (hAT1R) gene in age related chronic pathologies such as hypertension and associated renal disorders is not well known. The hAT1R gene has SNPs in its promoter that forms two haplotypes (Hap), Hap-I and Hap-II. Hap-I of AT1R gene is associated with hypertension in Caucasians. We have hypothesized here that age will alter the transcriptional environment of the cell and will regulate the expression of hAT1R gene in a haplotype-dependent manner...
August 1, 2018: American Journal of Hypertension
Bertram Pitt, Patrick Rossignol
No abstract text is available yet for this article.
July 28, 2018: American Journal of Hypertension
Undurti N Das
No abstract text is available yet for this article.
July 25, 2018: American Journal of Hypertension
Andrew Y Hwang, Chintan V Dave, Steven M Smith
Background: Withdrawing medications that interfere with blood pressure (BP) is recommended in patients with uncontrolled BP, yet real-world use of such agents is not well characterized among hypertensive individuals. We aimed to evaluate the use of BP-interfering prescription medications among U.S. patients with hypertension. Methods: This retrospective drug utilization study used medical and prescription claims (January 2008 - December 2014) in the Marketscan commercial claims database...
July 25, 2018: American Journal of Hypertension
Felix S Seibert, Fabian Bernhard, Ulrik Stervbo, Sinthuya Vairavanathan, Frederic Bauer, Benjamin Rohn, Nikolaos Pagonas, Nina Babel, Joachim Jankowski, Timm H Westhoff
Background: Blood pressure has been traditionally measured at peripheral arteries. In the past decade evidence has grown, that central aortic blood pressure may be a more powerful predictor for cardiovascular events, but data on its regulation are rare. The present work examines the impact of microgravity on central blood pressure for the first time. Methods: We performed seven parabolic flights with 22 seconds of weightlessness in each parabola. Hemodynamic parameters including central systolic blood pressure were measured non-invasively in a free-floating position in 20 healthy subjects (19-43 years of age)...
July 25, 2018: American Journal of Hypertension
Mahsa Shokouhi, Deqiang Qiu, Ayman Samman Tahhan, Arshed A Quyyumi, Ihab Hajjar
Background: Reports on the relative importance of the diastolic and systolic blood pressures (DBP and SBP) in age-related cognitive decline are mixed. Investigating the relation between DBP/SBP and functional and structural brain changes could elucidate which of the two measures is more critically important for brain function, and consequently, cognitive impairment. Methods: We investigated the association of SBP and DBP with cortical volume, cerebral blood flow (CBF), and white matter lesions (WML), in non-demented older adults with and without mild cognitive impairment (MCI) (N=265, 185 MCI, mean age=64 years)...
July 25, 2018: American Journal of Hypertension
Dae-Seop Shin, Kwang-Ik Yang, Doh-Eui Kim, Young Hwangbo, Brian B Koo, Yong Won Cho
Background: There is growing evidence of increased cardiovascular risk including hypertension in patients with periodic limb movements during sleep (PLMS). In a multiethnic cohort study, the association between prevalent hypertension and PLMS varied according to ethnicity. We evaluated whether PLMS is associated with hypertension in Koreans. Methods: We enrolled 1,163 subjects who had polysomnography (PSG) from two tertiary hospitals. All subjects completed a sleep questionnaire prior to the PSG study...
July 19, 2018: American Journal of Hypertension
Yusuke Oba, Satoshi Hoshide, Tomoyuki Kabutoya, Kazuomi Kario
BACKGROUND: Heart rate (HR) assessed by electrocardiogram (ECG-HR) and pulse rate (PR) measured in a physician's office (office-PR) are taken with subjects in different body positions-i.e., supine vs. sitting. Although analysis of HR differences according to body position could provide new practical insights, there have been few studies on the subject. We herein investigated whether the difference between office-PR and ECG-HR (delta HR) was associated with brain natriuretic peptide (BNP) levels and left ventricular mass (LVM)...
July 17, 2018: American Journal of Hypertension
Grazia Canciello, Costantino Mancusi, Maria Angela Losi, Raffaele Izzo, Bruno Trimarco, Giovanni de Simone, Nicola De Luca
BACKGROUND: Aortic root (AR) dimension (ARD) at the Valsalva sinuses has been associated with incident cardiovascular (CV) events in population-based studies, but this effect could be due to the association with increased left ventricular (LV) mass. There is also uncertainty on how to define clear-cut AR dilatation. Thus, we analyzed the Campania Salute Network (CSN) registry to (i) establish criteria for evaluation of ARD, (ii) propose cut-points for AR dilatation, and (iii) determine whether AR dilatation has prognostic value independent of LV hypertrophy (LVH)...
July 14, 2018: American Journal of Hypertension
Stephanie L Mayne, Disha Yellayi, Lindsay R Pool, William A Grobman, Kiarri N Kershaw
Background: Racial residential segregation is associated with higher rates of chronic hypertension, as well as greater risk of preterm birth and low birth weight. However, few studies have examined associations between segregation and hypertensive disorder of pregnancy (HDP). Methods: Electronic health records from 4,748 singleton births among non-Hispanic black women at Prentice Women's Hospital in Chicago, Illinois (2009-2013) were geocoded to the census tract level...
July 14, 2018: American Journal of Hypertension
Varshini Varadaraj, Ashok Vardhan, Lucy I Mudie, Sophie LaBarre, Yuhan Ong, Bingsong Wang, Cheryl Sherrod, David S Friedman
BACKGROUND: To determine the magnitude of uncontrolled hypertension and smoking among patients visiting an eye clinic, and ascertain if referral to care providers is effective. METHODS: Information on smoking status and blood pressure (BP) was collected among patients ≥18 years visiting an eye clinic. Those with high BP (systolic: ≥140 mm Hg and/or diastolic: ≥90 mm Hg) received a pamphlet on harms of hypertension on vision and were referred to a primary care physician...
July 14, 2018: American Journal of Hypertension
Yinkun Yan, Tao Zhang, Shengxu Li, Yang Liu, Lydia Bazzano, Jiang He, Jie Mi, Wei Chen
Background: To examine racial difference in the impact of long-term burden of blood pressure (BP) from childhood on adult renal function between middle-aged blacks and whites. Methods: The study cohort consisted of 1646 whites and 866 blacks aged 20-51 years at follow-up who had BP measured at least four times since childhood, with a mean follow-up period of 25.3 years. The area under the curve (AUC) was calculated as a measure of long-term burden of BP from childhood to adulthood...
July 13, 2018: American Journal of Hypertension
A Simons, Christopher J Moreland, P Kushalnagar
Background: In the U.S., roughly one-third of adults have hypertension; another third have prehypertension. The prevalence of hypertension in deaf American Sign Language (ASL) users is unknown. We address this gap through a descriptive study for the prevalence of hypertension in the American Deaf community, and discuss future directions to address this issue. Methods: Self-reported data for 1388 ASL-using deaf adults were compared to a secondary data of 2830 English-speaking hearing adults...
July 13, 2018: American Journal of Hypertension
Enayet K Chowdhury, Christopher M Reid, Ella Zomer, Darren J Kelly, Danny Liew
Background: Renal denervation (RDN) is effective at reducing blood pressure (BP) among patients with treatment-resistant hypertension (TRH). However, recent findings regarding the effectiveness of RDN for BP reduction compared to standard treatment of care (SoC) has initiated rigorous debate about its role in TRH management. In this study, we sought to determine the thresholds for cardiovascular risk and costs of RDN which would make RDN cost-effective. Methods: A Markov model was constructed to simulate cardiovascular events over a life time among TRH subjects aged 60-years at baseline, and without prior cardiovascular disease...
July 13, 2018: American Journal of Hypertension
Taiki Nishihara, Takanori Tokitsu, Daisuke Sueta, Masafumi Takae, Fumi Oike, Koichiro Fujisue, Hiroki Usuku, Seiji Takashio, Shinsuke Hanatani, Hisanori Kanazawa, Yuichiro Arima, Kenji Sakamoto, Yasuhiro Izumiya, Hiroshige Yamabe, Koichi Kaikita, Eiichiro Yamamoto, Kenichi Tsujita
Background: Although serum potassium (sK) levels are closely associated with the prognosis of chronic heart failure patients, the clinical significance of sK levels in cardiovascular outcomes of heart failure with preserved ejection fraction (HFpEF) patients is not fully understood. Methods: This study was a retrospective, single-center, observational study. We enrolled 506 consecutive HFpEF patients admitted to Kumamoto University Hospital and divided them into four groups according to the quartiles of the sK levels at discharge (Q1; sK < 4...
July 7, 2018: American Journal of Hypertension
Simonetta Genovesi, Antonina Orlando, Paola Rebora, Marco Giussani, Laura Antolini, Elisa Nava, Gianfranco Parati, Maria Grazia Valsecchi
BACKGROUND: Children's excess weight is a common problem due to low-quality diet and poor physical activity and is a risk factor associated with hypertension. Aim of this study was to assess the effect of a nonpharmacological multidisciplinary intervention on blood pressure (BP) and body weight in a population of children with excess weight and/or elevated BP. METHODS: Children consecutively referred to a Prevention of Cardiovascular Risk Clinic by the primary care pediatrician from 2009 to 2015 were assessed at baseline and followed up over time...
July 4, 2018: American Journal of Hypertension
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