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American Journal of Hypertension

Madhu V Singh
No abstract text is available yet for this article.
October 4, 2016: American Journal of Hypertension
Chong-Fu Jia, Yi-Nong Jiang, Zhi-Qiang Yang, Xi-Xia Sun, Yang Yu, Hao Wang, Yan Lu, Ai-Jun Chen, Zhao-Qian Wang
BACKGROUND: A new feature of coronary computed tomography angiography (CTA) is to estimate ascending aortic elasticity without additional cost, but its applicable benefit for prehypertension patients is still unclear. The aim of this study is to discuss the characteristic of ascending aortic elasticity for specific prehypertension patients and its risk factors. METHODS: Coronary CTA examinations of 398 participants were performed using a 128 slicer CT scanner. The differences of 3 ascending aortic elasticity related indices, including aortic distensibility (AD), aortic compliance (AC), and aortic stiffness (ASI), and anatomical measurements were analyzed among the normal, prehypertension, and primary hypertension groups...
September 29, 2016: American Journal of Hypertension
Yuichiro Yano
No abstract text is available yet for this article.
September 29, 2016: American Journal of Hypertension
Robert M Carey
The renin-angiotensin system (RAS) is arguably the most important and best studied hormonal system in the control of blood pressure (BP) and the pathogenesis of hypertension. The RAS features its main effector angiotensin II (Ang II) acting via its 2 major receptors, angiotensin type-1(AT1R) and type-2 (AT2R). In general, AT2Rs oppose the detrimental actions of Ang II via AT1Rs. AT2R activation induces vasodilation and natriuresis, but its effects to lower BP in hypertension have not been as clear as anticipated...
September 24, 2016: American Journal of Hypertension
Dingding Zhang, Dongfeng Gu, Jiang He, James E Hixson, Dabeeru C Rao, Changwei Li, Hua He, Jichun Chen, Jianfeng Huang, Jing Chen, Treva K Rice, Shufeng Chen, Tanika N Kelly
BACKGROUND: Single-marker and novel gene-based methods were employed to examine the associations of the serum/glucocorticoid regulated kinases (SGK) gene family with longitudinal blood pressure (BP) changes and hypertension incidence in a family-based cohort study. METHODS: Totally, 1,768 Chinese participants from the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) follow-up study were included in the current analyses. Nine BP measures were obtained at each of 3 visits during the GenSalt follow-up study...
September 24, 2016: American Journal of Hypertension
Carmine Savoia
No abstract text is available yet for this article.
September 22, 2016: American Journal of Hypertension
Panagiotis I Georgianos, Rajiv Agarwal
Contrary to the direct, graded, and causal relationship of hypertension with cardiovascular outcomes in the general population, among dialysis patients, blood pressure (BP) recorded either predialysis or postdialysis displays a U-shaped curve with mortality. This paradoxical phenomenon of lower BP or a decline in BP over time being associated with increased mortality and higher BP being associated with a lower mortality is described as "reverse" epidemiology of hypertension, raising substantial controversy on whether BP lowering causes harms or benefits among dialysis patients...
September 22, 2016: American Journal of Hypertension
Lina Bergman, Helena Åkerud, Anna Karin Wikström, Marita Larsson, Tord Naessen, Tansim Akhter
BACKGROUND: There is evidence of cerebral involvement among women with preeclampsia. Levels of the cerebral biomarkers neuron-specific enolase (NSE) and S100B are elevated during pregnancy in women developing preeclampsia. It is although not known if these biomarkers return to normal range postpartum. The aim with this study was to compare levels of S100B and NSE during pregnancy and 1 year postpartum in women who have had preeclampsia to women with normal pregnancies. METHODS: This study was a longitudinal study of cases (n = 53) with preeclampsia and controls (n = 58) consisted of normal pregnant women in matched gestational weeks...
September 21, 2016: American Journal of Hypertension
Carolina De Ciuceis, Claudia Rossini, Paolo Airò, Mirko Scarsi, Angela Tincani, Guido Alberto Massimo Tiberio, Silvia Piantoni, Enzo Porteri, Leonardo Solaini, Sarah Duse, Francesco Semeraro, Beatrice Petroboni, Luigi Mori, Maurizio Castellano, Alice Gavazzi, Claudia Agabiti Rosei, Enrico Agabiti Rosei, Damiano Rizzoni
BACKGROUND: Different components of the immune system, including innate and adaptive immunity (T-effector lymphocytes and T-regulatory lymphocytes-TREGs) may be involved in the development of hypertension. In addition, it was demonstrated in animal models that TREGs may prevent angiotensin II-induced hypertension and vascular injury/inflammation. However, no data are presently available in humans about possible relationships between T-lymphocyte subtypes and microvascular structural alterations...
September 21, 2016: American Journal of Hypertension
Alejandro de la Sierra, Julia Pareja, Pedro Armario, Ángela Barrera, Sergi Yun, Susana Vázquez, Laia Sans, Julio Pascual, Anna Oliveras
BACKGROUND: Sympathetic renal denervation (SRD) has been proposed as a therapeutic alternative for patients with resistant hypertension not controlled on pharmacological therapy. Two studies have suggested an effect of SRD in reducing short-term blood pressure variability (BPV). However, this has not been addressed in a randomized comparative trial. We aimed to compare the effects of spironolactone and SRD on circadian BP and BPV. METHODS: This is a post-hoc analysis of a randomized trial in 24 true resistant hypertensive patients (15 men, 9 women; mean age 64 years) comparing 50mg of spironolactone (n = 13) vs...
September 20, 2016: American Journal of Hypertension
Stephen P Juraschek, Natalie Daya, Lawrence J Appel, Edgar R Miller, Beverly Gwen Windham, Lisa Pompeii, Michael E Griswold, Anna Kucharska-Newton, Elizabeth Selvin
BACKGROUND: One-third of older adults fall each year. Orthostatic hypotension (OH) has been hypothesized as an important risk factor for falls, but findings from prior studies have been inconsistent. METHODS: We conducted a prospective study of the association between baseline OH (1987-1989) and risk of falls in the Atherosclerosis Risk in Communities (ARIC) Study. Falls were ascertained during follow-up via ICD-9 hospital discharge codes or Centers for Medicare & Medicaid Services claims data...
September 16, 2016: American Journal of Hypertension
Berhe W Sahle, Alice J Owen, Lindon M H Wing, Mark R Nelson, Garry L R Jennings, Christopher M Reid
BACKGROUND: Multivariable risk prediction models consisting of routinely collected measurements can facilitate early detection and slowing of disease progression through pharmacological and nonpharmacological risk factor modifications. This study aims to develop a multivariable risk prediction model for predicting 10-year risk of incident heart failure diagnosis in elderly hypertensive population. METHODS: The derivation cohort included 6083 participants aged 65 to 84 years at baseline (1995-2001) followed for a median of 10...
September 16, 2016: American Journal of Hypertension
Atsushi Nakagomi, Sho Okada, Toshihiro Shoji, Yoshio Kobayashi
BACKGROUND: Several studies have reported that central systolic blood pressure (SBP) estimation is affected by calibration methods. However, whether central pulsatile indices, namely pulse pressure (PP) and fractional PP (FPP) (defined as PP/mean arterial pressure (MAP)), also depend on calibration methods remains uninvestigated. This study assessed the accuracy and discriminatory ability of these indices for coronary atherosclerosis using 2 calibration methods. METHODS: Post-hoc analysis of a previous cross-sectional study (n = 139) that investigated the association between central pulsatile indices and coronary atherosclerosis...
September 15, 2016: American Journal of Hypertension
Érique José F Peixoto de Miranda, Márcio Sommer Bittencourt, Alessandra Carvalho Goulart, Itamar Souza Santos, José Geraldo Mill, Maria Ines Schmidt, Paulo Andrade Lotufo, Isabela J Martins Benseñor
BACKGROUND: There is little available data on carotid-femoral pulse wave velocity (cf-PWV) in subjects with subclinical hypothyroidism (SCH). We aimed to analyze the association between SCH and cf-PWV using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). METHODS: We included subjects with normal thyroid function (thyrotropin (TSH): 0.4-4.0 mIU/l, and normal free thyroxine (FT4: 0.8-1.9ng/dl) and SCH (TSH > 4.0 mIU/l and normal FT4) evaluated for cf-PWV in a cross-sectional analysis...
September 15, 2016: American Journal of Hypertension
Caroline Gusson Shimoura, Gisele Silvério Lincevicius, Erika Emy Nishi, Adriana Castello Costa Girardi, Karin Argenti Simon, Cassia de Toledo Bergamaschi, Ruy Ribeiro Campos
BACKGROUND: Renovascular hypertension (2-kidney 1-clip model (2K1C)) is characterized by renin-angiotensin system (RAS) activation. Increased Angiotensin II (AngII) leads to sympathoexcitation, oxidative stress, and alterations in sodium and water balance. AIM: The aim of this study was to evaluate whether a discrete increase in sodium chloride intake in 2K1C rats leads to changes in cardiovascular and autonomic function, oxidative stress, and renin angiotensin aldosterone system...
September 14, 2016: American Journal of Hypertension
Lorenzo Ghiadoni, Rosa Maria Bruno
No abstract text is available yet for this article.
September 13, 2016: American Journal of Hypertension
Cameron G McCarthy, Camilla F Wenceslau, Styliani Goulopoulou, Babak Baban, Takayuki Matsumoto, R Clinton Webb
BACKGROUND: Innate immune system responses to damage-associated molecular patterns (DAMPs) are involved in hypertension. However, the mechanisms of this contribution are not well understood. Circulating mitochondrial DNA is a DAMP that activates Toll-like receptor (TLR) 9 and is elevated in spontaneously hypertensive rats (SHR). Therefore, we hypothesized that lysosomotropic agent chloroquine (CQ) would impair TLR9 signaling, as well as prevent the development of hypertension and immune cell recruitment to the vasculature, in SHR...
September 13, 2016: American Journal of Hypertension
Tanja Dudenbostel, David A Calhoun
BACKGROUND: Multiple studies indicate that primary aldosteronism (PA) is common in patients with resistant hypertension, with an estimated prevalence of approximately 20%. Additional studies suggest that beyond this 20% of patients with classical PA, there is a larger proportion of patients with lesser degrees of hyperaldosteronism which contributes even more broadly to antihypertensive treatment resistance. Given these observations, it is intuitive that use of aldosterone antagonists will provide antihypertensive benefit in patients with resistant hypertension and evidence of aldosterone excess...
September 8, 2016: American Journal of Hypertension
Chenkai Wu, Michael G Shlipak, Robert S Stawski, Carmen A Peralta, Bruce M Psaty, Tamara B Harris, Suzanne Satterfield, Eric J Shiroma, Anne B Newman, Michelle C Odden
BACKGROUND: Level of blood pressure (BP) is strongly associated with cardiovascular (CV) events and mortality. However, it is questionable whether mean BP can fully capture BP-related vascular risk. Increasing attention has been given to the value of visit-to-visit BP variability. METHODS: We examined the association of visit-to-visit BP variability with mortality, incident myocardial infarction (MI), and incident stroke among 1,877 well-functioning elders in the Health, Aging, and Body Composition Study...
September 6, 2016: American Journal of Hypertension
Shang-Yu Liu, Xiao-Cui Duan, Sheng Jin, Xu Teng, Lin Xiao, Hong-Mei Xue, Yu-Ming Wu
BACKGROUND: Hydrogen sulfide (H2S) is an important endogenous gaseous transmitter in many physiological functions. Plasma H2S decreased, and angiotensin II (Ang II) type 1 receptor (AT1R) increased in the myocardial tissues in 2-kidney 1-clip (2K1C) rats than in normotensive rats. Accumulating evidences suggest that H2S inhibited Ang II/AT1R pathway to regulate cardiovascular function. Therefore, we hypothesized that H2S may exert beneficial effects on myocardial remodeling in 2K1C rat models of renovascular hypertension...
September 6, 2016: American Journal of Hypertension
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