journal
MENU ▼
Read by QxMD icon Read
search

Reproductive Toxicology

journal
https://www.readbyqxmd.com/read/27888070/phosphoramide-mustard-induces-autophagy-markers-and-mtor-inhibition-prevents-follicle-loss-due-to-phosphoramide-mustard-exposure
#1
Jill A Madden, Porsha Q Thomas, Aileen F Keating
Phosphoramide mustard (PM) is an ovotoxic metabolite of cyclophosphamide. Postnatal day 4 Fisher 344 rat ovaries were exposed to vehicle control (1% DMSO) or PM (60μM) ± LY294002 or rapamycin for 2 or 4 d. Transmission election microscopy revealed abnormally large golgi apparatus and electron dense mitochondria in PM-exposed ovaries prior to and at the time of follicle depletion. PM exposure increased (P<0.05) mRNA abundance of Bbc3, Cdkn1a, Ctfr, Edn1, Gstp1, Nqo1, Tlr4, Tnfrsfla, Txnrd1 and decreased (P<0...
November 22, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27888069/vertebrate-embryos-as-tools-for-anti-angiogenic-drug-screening-and-function
#2
Shaunna L Beedie, Alexandra J Diamond, Lucas Rosa Fraga, William D Figg, Neil Vargesson
The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new anti-angiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.
November 22, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27871864/review-of-developmental-origins-of-health-and-disease-publications-in-environmental-epidemiology
#3
Jerrold J Heindel, Lesley A Skalla, Bonnie R Joubert, Caroline H Dilworth, Kimberly A Gray
The Developmental Origins of Health and Disease (DOHaD) scientific field investigates the influence of early life environmental stressors on later life health outcomes. Environmental chemical exposures are a particular focus area within this field. Although the DOHaD hypothesis originated in the 1990s, the data evaluating this hypothesis in environmental epidemiology has not been comprehensively summarized. We conducted a scoping literature review to describe the human evidence for the DOHaD hypothesis and to identify, 1) where there may be reasonable data to draw conclusions, and 2) areas warranting further research...
November 18, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27856370/effect-of-folic-acid-supplementation-on-preterm-delivery-and-small-for-gestational-age-births-a-systematic-review-and-meta-analysis
#4
Qian Zhang, Yuanyuan Wang, Xiaona Xin, Ya Zhang, Dujia Liu, Zuoqi Peng, Yuan He, Jihong Xu, Xu Ma
OBJECTIVE: To investigate the effect of folic acid (FA) supplementation on the risks of preterm delivery (PTD) and small for gestational age births (SGA). DATA SOURCES: Cohort studies were identified from MEDLINE, EMBASE, the Cochrane Library, CINAHL, and CBM from inception to January 2015. PARTICIPANTS AND INCLUDED STUDIES: Healthy women who want to get pregnancy or being pregnant. MAIN OUTCOME MEASURES: PTD and SGA...
November 14, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27851994/pregnancy-outcomes-after-maternal-varenicline-use-analysis-of-surveillance-data-collected-by-the-european-network-of-teratology-information-services
#5
J L Richardson, S Stephens, L M Yates, O Diav-Citrin, J Arnon, D Beghin, A Kayser, D Kennedy, D Cupitt, B Te Winkel, M Peltonen, Y C Kaplan, S H L Thomas
: Varenicline is a smoking cessation aid for which limited data exist concerning safety during human pregnancy. This multicentre prospective observational comparative cohort study was undertaken using surveillance data collected by the European Network of Teratology Information Services. The study sample consisted of 89 varenicline exposed pregnancies and two matched comparator groups; 267 non-teratogen exposed (NTE) controls and 78 exposed to nicotine replacement therapy or bupropion (NRT/B) for smoking cessation...
November 13, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27851993/associations-of-urinary-phthalate-and-phenol-biomarkers-with-menarche-in-a-multiethnic-cohort-of-young-girls
#6
Mary S Wolff, Ashley Pajak, Susan M Pinney, Gayle C Windham, Maida Galvez, Michael Rybak, Manori J Silva, Xiaoyun Ye, Antonia M Calafat, Lawrence H Kushi, Frank M Biro, Susan L Teitelbaum
To study potential environmental influences on puberty in girls, we investigated urinary biomarkers in relation to age at menarche. Phenols and phthalates were measured at baseline (6-8 years of age). Menarche was ascertained over 11 years for 1051 girls with menarche and biomarkers. Hazards ratios were estimated from Cox models adjusted for race/ethnicity and caregiver education (aHR, 95% confidence intervals [CI] for 5th vs 1st quintile urinary biomarker concentrations). 2,5-Dichlorophenol was associated with earlier menarche (aHR 1...
November 13, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27838387/identification-of-vascular-disruptor-compounds-by-analysis-in-zebrafish-embryos-and-mouse-embryonic-endothelial-cells
#7
Catherine W McCollum, Javier Conde Vancells, Charu Hans, Mercedes Vazquez-Chantada, Nicole Kleinstreuer, Tamara Tal, Thomas Knudsen, Shishir S Shah, Fatima A Merchant, Richard H Finnell, Jan-Åke Gustafsson, Robert Cabrera, Maria Bondesson
To identify vascular disruptor compounds (VDCs), this study utilized an in vivo zebrafish embryo vascular model in conjunction with a mouse endothelial cell model to screen a subset of the U.S. Environmental Protection Agency (EPA) ToxCast Phase I chemical inventory. In zebrafish, 161 compounds were screened and 34 were identified by visual inspection as VDCs, of which 28 were confirmed as VDCs by quantitative image analysis. Testing of the zebrafish VDCs for their capacity to inhibit endothelial tube formation in the murine yolk-sac-derived endothelial cell line C166 identified 22 compounds that both disrupted zebrafish vascular development and murine endothelial in vitro tubulogenesis...
November 9, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27838386/self-reported-mobile-phone-use-and-semen-parameters-among-men-from-a-fertility-clinic
#8
Ryan C Lewis, Lidia Mínguez-Alarcón, John D Meeker, Paige L Williams, Gabor Mezei, Jennifer B Ford, Russ Hauser
There is increasing concern that use of mobile phones, a source of low-level radio-frequency electromagnetic fields, may be associated with poor semen quality, but the epidemiologic evidence is limited and conflicting. The relationship between mobile phone use patterns and markers of semen quality was explored in a longitudinal cohort study of 153 men that attended an academic fertility clinic in Boston, Massachusetts. Information on mobile phone use duration, headset or earpiece use, and the body location in which the mobile phone was carried was ascertained via nurse-administered questionnaire...
November 9, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27836536/doppler-screening-and-predictors-of-adverse-outcomes-in-high-risk-pregnancies-affected-by-tobacco
#9
Alison Stalzer, Dara Seybold, Deena Hossino, Mike Broce, Byron Calhoun
OBJECTIVE: The purpose of this study was to investigate associations between Doppler measurements and adverse outcomes in an obstetric population with high tobacco use. METHODS: This retrospective study included patients with Doppler data (umbilical systolic/diastolic velocity ratios (S/D), uterine S/D, uterine left/right ratio index (RI)). Receiver operator characteristic curve analysis determined cut-off elevated Doppler indices. Stepwise logistic regression was used to predict adverse outcomes...
November 9, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27836535/effect-of-the-herbicide-atrazine-and-its-metabolite-dact-on-bovine-sperm-quality
#10
Alisa Komsky-Elbaz, Zvi Roth
Atrazine (ATZ), one of the most extensively used herbicides, is considered a ubiquitous environmental contaminant. ATZ is a known endocrine disruptor, and deleterious effects on reproductive function have been shown, even at low, ecologically relevant doses (0.1-3μg/L). Once it enters the body, ATZ is metabolized to various metabolites, which are further detected in the urine, serum and tissues. In mammals, the major ATZ metabolite is diaminochlorotriazine (DACT). The current study focuses on direct effects of low doses of ATZ and DACT on bovine sperm isolated from ejaculates or epididymis compartments (head, body and tail)...
November 9, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27832950/the-chick-embryo-chorioallantoic-membrane-cam-assay
#11
Domenico Ribatti
During avian development the mesodermal layers of the allantois and chorion fuse to form the chorioallantoic membrane (CAM). This structure rapidly expands generating a rich vascular network that provides an interface for gas and waste exchange. The CAM allows to study tissue grafts, tumor growth and metastasis, drugs delivery and toxicologic analysis, and angiogenic and anti-angiogenic molecules. The CAM is relatively simple, quick, and low-cost model that allows screening of a large number of pharmacological samples in a short time; does not require administrative procedures for obtaining ethics committee approval for animal experimentation...
November 7, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27829162/second-trimester-amniotic-fluid-bisphenol-a-concentration-is-associated-with-decreased-birth-weight-in-term-infants
#12
Sara E Pinney, Clementina A Mesaros, Nathaniel W Snyder, Christine M Busch, Rui Xiao, Sara Aijaz, Naila Ijaz, Ian A Blair, Jeanne M Manson
Bisphenol A (BPA) is an endocrine disrupting chemical with ubiquitous environmental exposure. Animal studies have demonstrated that in utero BPA exposure leads to increased adult body weight. Our aim was to characterize human fetal BPA exposure by measuring BPA concentration in second trimester amniotic fluid (AF) samples and to study its relationship with birth weight (BW) in full term infants. To achieve these goals, we developed a total BPA assay utilizing derivatization with pentafluorobenzyl followed by analysis with LC-ECAPCI-MS/MS with a limit of detection of 0...
November 6, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27825960/a-special-issue-on-the-environment-and-developmental-origins-of-health-and-diseases
#13
EDITORIAL
Jerrold J Heindel
No abstract text is available yet for this article.
November 5, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27818298/involvement-of-l-type-amino-acid-transporter-1-in-the-transport-of-gabapentin-into-human-placental-choriocarcinoma-cells
#14
Ayako Furugen, Yuri Ishiguro, Masaki Kobayashi, Katsuya Narumi, Ayako Nishimura, Takeshi Hirano, Ken Iseki
Gabapentin (GBP) is a widely used antiepileptic drug, with potential for use in the treatment of epilepsy in pregnant women. Although studies have examined GBP transport mechanisms across the blood-brain barrier, kidney, and intestine, the mechanism in the placenta has not been fully elucidated. We previously reported that GBP accumulates at high concentrations in human placental choriocarcinoma BeWo cells. The purpose of this study was to examine the transport mechanism of GBP in placental choriocarcinoma cells (BeWo and JEG-3), and to identify the carrier involved...
November 3, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27810254/vascular-ontogeny-within-selected-thoracoabdominal-organs-and-the-limbs
#15
John M DeSesso
The cardiovascular system is fundamental to life. Its vessels are the conduits for delivery of nutrients and oxygen to organs and the removal of wastes. During embryonic development, the vascular system is instrumental in the formation of organs. It contributes to the form and pattern of organs as diverse as the limbs and the gonads. Recent advances in molecular biology and genomics have afforded great insight to the control of vascular development at subcellular levels of organization. Nevertheless, there is little assembled information concerning the vascular development of the organ systems of the body...
October 31, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27773741/arterial-dysgenesis-and-limb-defects-clinical-and-experimental-examples
#16
Neil Vargesson, David R Hootnick
Limb malformations are amongst the most common and visible birth effects. Causes have been purported to include genetic aberrations as well as teratogens, such as thalidomide. Here we review the evidence for vascular disruption in the genesis of limb malformations through abnormal arterial transitioning and from events such as amniocentesis, uterine constriction, and through teratogen exposure. We use several clinical and experimental examples and highlight the need to understand more about the role the vascular system plays in the molecular mechanisms underpinning normal limb development...
October 20, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27760374/metabolism-disrupting-chemicals-and-metabolic-disorders
#17
Jerrold J Heindel, Bruce Blumberg, Mathew Cave, Ronit Machtinger, Alberto Mantovani, Michelle A Mendez, Angel Nadal, Paola Palanza, Giancarlo Panzica, Robert Sargis, Laura N Vandenberg, Frederick Vom Saal
The recent epidemics of metabolic diseases, obesity, type 2 diabetes(T2D), liver lipid disorders and metabolic syndrome have largely been attributed to genetic background and changes in diet, exercise and aging. However, there is now considerable evidence that other environmental factors may contribute to the rapid increase in the incidence of these metabolic diseases. This review will examine changes to the incidence of obesity, T2D and non-alcoholic fatty liver disease (NAFLD), the contribution of genetics to these disorders and describe the role of the endocrine system in these metabolic disorders...
October 16, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27751757/genomic-and-in-silico-analyses-of-crbn-gene-and-thalidomide-embryopathy-in-humans
#18
Fernanda Sales Luiz Vianna, Thayne Woycinck Kowalski, Luciana Tovo-Rodrigues, Alice Tagliani-Ribeiro, Bibiane Armiliato Godoy, Lucas Rosa Fraga, Maria Teresa Vieira Sanseverino, Mara Helena Hutz, Lavínia Schuler-Faccini
Thalidomide causes Thalidomide Embryopathy (TE), but is largely used to treat several conditions. Investigations with Cereblon, a thalidomide target protein encoded by CRBN gene, have helped to understand thalidomide therapeutic and teratogenic properties. We sequenced CRBN-thalidomide binding region in 38 TE individuals and 136 Brazilians without congenital anomalies, and performed in silico analyses. Eight variants were identified, seven intronic and one in 3'UTR. TE individuals had rare variants in higher frequency than the non-affected group (p=0...
October 14, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27702680/response-to-the-questions-submitted-by-mr-reichmann
#19
Marlena Fejzo, Kimber MacGibbon, Patrick Mullin
No abstract text is available yet for this article.
October 1, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27697604/fetal-safety-profile-of-aromatase-inhibitors-animal-data
#20
REVIEW
Gian Mario Tiboni, Adalisa Ponzano
Aromatase inhibitors (AIs) are a class of drugs that act by blocking the production of estrogens from androgens. The current review concentrates on the prenatal developmental toxicity of AIs in experimental models. Available data indicate that AIs may affect pregnancy at human therapeutic or lower doses. The window of vulnerability to AIs is not limited to organogenesis, but also includes the preimplantation stage and fetal periods. Decreased embryo/fetal survival was the prominent treatment-related effect...
September 30, 2016: Reproductive Toxicology
journal
journal
29774
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"