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Reproductive Toxicology

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https://www.readbyqxmd.com/read/28793237/fetal-sex-dependent-genomic-responses-in-the-circulating-lymphocytes-of-arsenic-exposed-pregnant-women-in-new-hampshire
#1
Paige A Bommarito, Elizabeth Martin, Lisa Smeester, Thomas Palys, Emily R Baker, Margaret R Karagas, Rebecca C Fry
Exposure to inorganic arsenic (iAs) during pregnancy is associated with adverse health outcomes present both at birth and later in life. A mechanism may include epigenetic and genomic alteration in fetal genes involved in immune functioning. To investigate the role of the maternal immune response to in utero iAs exposure, we conducted an analysis of immune-related genes in pregnant women from the New Hampshire Birth Cohort Study. A set of 31 genes were identified with altered expression in association with levels of urinary total arsenic, urinary iAs, urinary monomethylated arsenic and urinary dimethylated arsenic...
August 6, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28789864/ethanol-exposure-leads-to-disorder-of-blood-island-formation-in-early-chick-embryo
#2
Guang Wang, Bin-Zhen Chen, Chao-Jie Wang, Jing Zhang, Lin-Rui Gao, Manli Chuai, Yongping Bao, Xuesong Yang
Ethanol's effect on embryonic vasculogenesis and its underlying mechanism is obscure. Using VE-cadherin in situ hybridization, we found blood islands formation was inhibited in area opaca, but abnormal VE-cadherin(+) cells were seen in area pellucida. We hypothesise ethanol may affect blood island progenitor cell migration and differentiation. DiI and in vitro experiments revealed ethanol inhibited cell migration, Quantitative PCR analysis revealed that ethanol exposure enhanced cell differentiation in area pellucida of HH5 chick embryos and repressed cell differentiation in area pellucida of HH8 chick embryos...
August 5, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28780397/neonatal-exposure-to-a-glyphosate-based-herbicide-alters-uterine-decidualization-in-rats
#3
Paola I Ingaramo, Jorgelina Varayoud, María M Milesi, Marlise Guerrero Schimpf, Ramiro Alarcón, Mónica Muñoz-de-Toro, Enrique H Luque
We investigated whether defective modulation of uterine signaling may cause decidualization failure in rats neonatally exposed to a glyphosate-based herbicide (GBH). Female pups received vehicle or 2mg/kg of GBH from postnatal day (PND) 1 to PND7. On PND8 and PND21, Wnt5a and β-catenin expression was evaluated in uterine samples. On gestational day (GD) 9, Wnt5a, Wnt7a and β-catenin expression and Dkk1 and sFRP4 mRNA were evaluated on implantation sites. On PND8, GBH-exposed rats showed increased Wnt5a and β-catenin expression in luminal epithelium (LE), whereas on PND21, they showed increased Wnt5a and β-catenin expression in subepithelial stroma but decreased β-catenin expression in glandular epithelium...
August 2, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28780396/mobile-phone-1800mhz-radiation-impairs-female-reproduction-in-mice-mus-musculus-through-stress-induced-inhibition-of-ovarian-and-uterine-activity
#4
Saba Shahin, Surya Pal Singh, Chandra Mohini Chaturvedi
Present study investigated the long-term effects of mobile phone (1800MHz) radiation in stand-by, dialing and receiving modes on the female reproductive function (ovarian and uterine histo-architecture, and steroidogenesis) and stress responses (oxidative and nitrosative stress). We observed that mobile phone radiation induces significant elevation in ROS, NO, lipid peroxidation, total carbonyl content and serum corticosterone coupled with significant decrease in antioxidant enzymes in hypothalamus, ovary and uterus of mice...
August 2, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28774688/prenatal-exposure-to-drinking-water-chlorination-by-products-cytochrome-p450-gene-polymorphisms-and-small-for-gestational-age-neonates
#5
Samuella G Bonou, Patrick Levallois, Yves Giguère, Manuel Rodriguez, Alexandre Bureau
Genetic susceptibility may modulate chlorination by-products (CBPs) effects on fetal growth, especially genes coding for the cytochrome P450 involved in the metabolism of CBPs and steroidogenesis. In a case-control study of 1432 mother-child pairs, we assessed the association between maternal and child single nucleotide polymorphisms (SNPs) within CYP1A2, CYP2A6, CYP2D6 and CYP17A1 genes and small-for-gestational-age neonates (SGA<10th percentile) as well as interaction between these SNPs and maternal exposure to trihalomethanes or haloacetic acids (HAAs) during the third trimester of pregnancy...
July 31, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28774687/the-environment-and-male-reproduction-the-effect-of-cadmium-exposure-on-reproductive-system-and-semen-quality-and-its-implication-in-fertility
#6
REVIEW
Cristina de Angelis, Mariano Galdiero, Claudia Pivonello, Ciro Salzano, Daniele Gianfrilli, Prisco Piscitelli, Andrea Lenzi, Annamaria Colao, Rosario Pivonello
Cadmium is an environmental pollutant known as endocrine disruptor. Testis is particularly susceptible to cadmium, and testis injury occurs at high but even low levels of exposure. Cadmium reproductive toxicity is mediated by multiple mechanisms, including structural damage to testis vasculature and blood-testis barrier, inflammation, cytotoxicity on Sertoli and Leydig cells, oxidative stress, apoptosis, epigenetic actions, and disturbance of the hypothalamus-pituitary-gonadal axis. The current review outlines epidemiological observational findings from environmental and occupational exposure in humans, and reports experimental studies in humans and animals...
July 31, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28768143/intrauterine-exposure-to-17%C3%AE-oestradiol-e2-impairs-postnatal-development-in-both-female-and-male-prostate-in-gerbil
#7
Bruno D A Sanches, Juliana M Santos, Bruno C Zani, Manoel F Biancardi, Fernanda C A Santos, Rejane M Góes, Patricia S L Vilamaior, Sebastião R Taboga
We employed histological techniques to assess the effects of intrauterine exposure to different dosages of E2 on male and female Mongolian gerbils on the postnatal development of the prostate. E2 promotes alterations this gland branches in the female, but not in males, even at low dosage, at higher dosages, acini of altered aspect are verified in the male and female prostate, as well as a decrease in branching number, reduced cell proliferation and staining for FGF10, simultaneously to the increased labelling for TGFβ1, which may account for alterations on branching of the prostate...
July 30, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28755858/iodine-is-associated-to-semen-quality-in-men-who-undergo-consultations-for-infertility
#8
Ana B Partal-Lorente, Vicente Maldonado-Ezequiel, Luis Martinez-Navarro, Isidoro Herrera-Contreras, Carolina Gutierrez-Repiso, Eduardo García-Fuentes, Piedad Santiago-Fernandez
The role that adequate iodine intake could have on the male reproductive function is not entirely known. The aim of this study is to determine whether there is a relation between male infertility and urinary and semen iodine levels in 96 couples who underwent consultation for infertility. The median of semen iodine was higher in men who consumed iodized salt than in those who consumed non-iodized salt (p=0.019). Men with a higher semen iodine level had more morphological alterations in spermatozoa (p=0.032)...
July 26, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28754630/reproductive-and-developmental-toxicology-studies-with-gantenerumab-in-ps2app-transgenic-mice
#9
Paul Barrow, Loris Villabruna, Alan Hoberman, Bernd Bohrmann, Wolfgang F Richter, Christine Schubert
Gantenerumab is intended for the treatment of Alzheimer's disease. It is a fully human recombinant monoclonal IgG1 which binds aggregated forms of amyloid beta such as Aβ oligomers, fibrils and neuritic amyloid plaques. A full package of developmental and reproductive toxicity (DART) studies was performed in the PS2APP double-transgenic mouse model of Alzheimer's disease. A combined fertility and embryo fetal development study and a pre-and post-natal development study were performed. The PS2APP mouse model allowed a more complete DART evaluation than would have been possible in conventional species or strains which do not express the target antigen of gantenerumab...
July 25, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28746836/a-human-induced-pluripotent-stem-cell-based-in-vitro-assay-predicts-developmental-toxicity-through-a-retinoic-acid-receptor-mediated-pathway-for-a-series-of-related-retinoid-analogues
#10
Jessica A Palmer, Alan M Smith, Laura A Egnash, Michael R Colwell, Elizabeth L R Donley, Fred R Kirchner, Robert E Burrier
The relative developmental toxicity potency of a series of retinoid analogues was evaluated using a human induced pluripotent stem (iPS) cell assay that measures changes in the biomarkers ornithine and cystine. Analogue potency was predicted, based on the assay endpoint of the ornithine/cystine (o/c) ratio, to be all-trans-retinoic acid>TTNPB>13-cis-retinoic acid≈9-cis-retinoic acid>acitretin>etretinate>retinol. These rankings correlate with in vivo data and demonstrate successful application of the assay to rank a series of related toxic and non-toxic compounds...
July 23, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28743560/fertility-and-anogenital-distance-in-women
#11
Tamar Wainstock, Ilana Shoham-Vardi, Eyal Sheiner, Asnat Walfisch
BACKGROUND: Human and animal studies have found an association between prenatal androgen exposure and the anogenital distance (AGD). The aims of this study were to study the association between female AGD, reproductive health and background characteristics. METHODS: This was a cross sectional study, in which AGD were measured in 300 pregnant women who were recruited early during the first stage of labor. Demographic and health characteristics were collected and studied in association with AGD measurements...
July 22, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28739294/polycyclic-aromatic-hydrocarbons-and-female-reproductive-health-a-scoping-review
#12
REVIEW
Ashley L Bolden, Johanna R Rochester, Kim Schultz, Carol F Kwiatkowski
Polycyclic aromatic hydrocarbons (PAHs) are a class of common persistent environmental pollutants found in water, air, soil, and plants and can be released by natural sources. However, the majority of atmospheric PAHs are from vehicular emissions, coal-burning plants, and the production and use of petroleum-derived substances. Exposure to PAHs has been implicated in cancer and other diseases, including reproductive disorders. This scoping review is a preliminary step that explores the utility and feasibility of completing a systematic review evaluating the effect of PAHs on female reproduction...
July 21, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28739212/conference-programme-45th-annual-conference-of-the-european-teratology
#13
(no author information available yet)
No abstract text is available yet for this article.
July 21, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28736173/low-doses-of-17%C3%AE-ethinyl-estradiol-alter-the-maternal-brain-and-induce-stereotypies-in-cd-1-mice-exposed-during-pregnancy-and-lactation
#14
Mary C Catanese, Laura N Vandenberg
Maternal care is critical for the survival, development and long-term success of offspring. Despite our current understanding of the role of endogenous estrogen in both maternal behavior and the maternal brain, the potential effects of exogenous estrogens on these endpoints remain poorly understood. Here, pregnant CD-1 mice were exposed to low doses of 17α-ethinyl estradiol (EE2), commonly used as a positive control in studies of other xenoestrogens, from day 9 of pregnancy until weaning. Using traditional maternal behavior assays, we document no significant changes in maternal behavior throughout the lactational period...
July 21, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28736174/effects-of-cigarette-smoke-extracts-on-cell-cycle-cell-migration-and-endocrine-activity-in-human-placental-cells
#15
Cho-Won Kim, Hae-Miru Lee, Kyuhong Lee, Bumseok Kim, Moo-Yeol Lee, Kyung-Chul Choi
Maternal smoking during pregnancy is known to be related to adverse pregnancy results associated with trophoblast proliferation and cell cycle progression. Moreover, many previous studies have shown that cigarette smoke is correlated with human chorionic gonadotropin beta (hCG-β) subunit produced from syncytiotrophoblasts during pregnancy. Thus, we further investigated whether cigarette smoke extract (CSE) affects the cell proliferation, migration and endocrine hormone activity of JEG-3 human placental cancer cells...
July 20, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28734970/genetic-variation-in-low-dose-effects-of-neonatal-des-exposure-in-female-rats
#16
Hideo Ohmukai, Tsukasa Negura, Shigehiro Tachibana, Ryo Ohta
To confirm genetic variation in low-dose effects of diethylstilbestrol (DES), two inbred strains of rats, which have been selectively bred for high- and low-avoidance learning (HAA and LAA, respectively), were used in this study. LAA rats characteristically show later sexual maturation, earlier reproductive senescence, and lower body weight as compared to HAA rats. Female neonates of each strain were daily administered DES by oral gavage at doses of 0 (vehicle only), 0.05 and 0.5μg/kg for the first 5days after birth...
July 19, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28729172/ascorbic-acid-supplementation-partially-prevents-the-delayed-reproductive-development-in-juvenile-male-rats-exposed-to-rosuvastatin-since-prepuberty
#17
Gabriel Adan Araújo Leite, Thamiris Moreira Figueiredo, Marciana Sanabria, Ana Flávia Mota Gonçalves Dias, Patrícia Villela E Silva, Airton da Cunha Martins Junior, Fernando Barbosa Junior, Wilma De Grava Kempinas
Dyslipidemias are occurring earlier in the population due to the increase of obesity and bad eating habits. Rosuvastatin inhibits the enzyme HMG-CoA reductase, decreasing total cholesterol. Ascorbic acid is an important antioxidant compound for male reproductive system. This study aimed to evaluate whether ascorbic acid supplementation may prevent the reproductive damage provoked by rosuvastatin administration at prepuberty. Male pups were distributed into six experimental groups that received saline solution 0...
July 18, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28729173/bisphenol-a-impairs-decidualization-of-human-uterine-stromal-fibroblasts
#18
Mark R Olson, Renwei Su, Jodi A Flaws, Asgerally T Fazleabas
This study examined the effect of bisphenol A (BPA) exposure on human uterine stromal fibroblast cells (HuF) undergoing decidualization. HuF cells were isolated and cultured for eight days in the presence of a decidualization-inducing cocktail, while concurrently exposed to physiological and supra-physiologic doses of BPA (1ng/mL, 10ng/mL, 0.5μg/mL, 10μg/mL and 20μg/mL). Decidualization markers, steroid hormone receptors and cell cycle gene expression were detected by qRT-PCR and cellular proliferation was assessed by KI-67 immunofluorescent staining and MTS assay...
July 17, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28705580/relationship-between-serum-dioxin-like-polychlorinated-biphenyls-and-post-testicular-maturation-in-human-sperm
#19
Raiza Paul, Julia Moltó, Nuria Ortuño, Alejandro Romero, Carlos Bezos, Jon Aizpurúa, Mª José Gómez-Torres
The relationship between dioxin-like polychlorinated biphenyl (DL-PCB) levels in serum and semen parameters were investigated. Our case-control included two groups of patients. Total concentrations of PCBs were significantly higher in the low semen quality (n=24) than in the normal semen quality (n=26) group. A significant negative correlation was found between PCB 126 and viability in men with low semen quality, while PCBs 77 and 81 were positively correlated with morphology, and PCB 118, mono-ortho and total DL-PCBs were positively correlated with volume...
July 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28697965/beyond-organoids-in-vitro-vasculogenesis-and-angiogenesis-using-cells-from-mammals-and-zebrafish
#20
REVIEW
Muhammad Ibrahim, Michael K Richardson
The ability to culture complex organs is currently an important goal in biomedical research. It is possible to grow organoids (3D organ-like structures) in vitro; however, a major limitation of organoids, and other 3D culture systems, is the lack of a vascular network. Protocols developed for establishing in vitro vascular networks typically use human or rodent cells. A major technical challenge is the culture of functional (perfused) networks. In this rapidly advancing field, some microfluidic devices are now getting close to the goal of an artificially perfused vascular network...
July 8, 2017: Reproductive Toxicology
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