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Reproductive Toxicology

Liaoliao Hu, Tingting Peng, Jian Huang, Tie Su, Ruichen Luo, Yuehui Zheng, Zhisheng Zhong, Peiling Yu, Kun Nie, Liping Zheng
As a plasticizer widely used in society, tri-ortho-cresyl phosphate (TOCP) is reported to inhibit spermatogenesis and growth of spermatogonial stem cells. However, its effects on female reproductive system are virtually unknown. The present study investigated the effects of TOCP on ovarian follicle development by using mouse model of chronic TOCP exposure, and examined the expression of the core components of the Hippo pathway, which had been proven to be crucial for ovarian follicle development. Furthermore, through up-regulation of Hippo-yes-associated protein 1 (Yap1) in ovaries, the potential protective effects of Yap1 over-expression on TOCP-induced ovarian dysfunction were observed...
November 12, 2018: Reproductive Toxicology
Fuchen Xie, Xuedong Chen, Shiqi Weng, Tianxinyu Xia, Xinyi Sun, Tao Luo, Peng Li
Di-n-butyl phthalate (DBP), a plastic-derived, endocrine-disrupting chemical, is regarded as a male reproductive toxicant. In this study, we investigated the in vitro actions of DBP and mono-n-butyl phthalate (MBP, the main metabolite of DBP) on human sperm functions. Human sperm were treated with DBP (2 nM-6 μM), MBP (1 nM-3 μM), and a mixture of DBP and MBP in vitro. The results showed that only DBP at 6 μM, a dose reported in semen of infertile men, MBP at 3 μM (three times of the reported maximum MBP concentration in semen), and their mixture, had obvious adverse effects on sperm motility, penetration ability and capacitation...
November 2, 2018: Reproductive Toxicology
Guili Zhao, Jinhua Mo, Ting Zheng, Yongchao Li, Xunwei Wu, Jun Huang, Guihong Liu, Zhaofeng Huang, Yu Bolan
Epidemiological studies suggested that exposure to cigarette smoke early in life is associated with long-term health risks. Using a nuclear factor erythroid 2-related factor 2 (Nrf2) knockout (KO) mouse model, we found the sperm concentration and sperm motility were significantly lower in mice exposed to cigarette smoke extract (CSE) beginning at 4 weeks of age compared to 8 week-old mice. Additionally, CSE exposure significantly decreased in vitro fertilization (IVF) and blastocyst rates in the Nrf2 KO mice compared to the wild-type (WT) mice...
November 1, 2018: Reproductive Toxicology
April Zambelli-Weiner, Christina Via, Matt Yuen, Daniel J Weiner, Russell S Kirby
This study investigates risk of specific structural birth defects associated with ondansetron exposure during the first trimester in a large US commercially-insured population. Medical claims data were obtained from Truven Health Analytics for 864,083 mother-infant pairs from 2000 to 2014. Logistic regression was used to measure the association between first trimester exposure to ondansetron and risk of cardiac defects, orofacial clefts and other specific structural defects in offspring. First trimester exposure to ondansetron was associated with increased risk of cardiac (OR: 1...
October 29, 2018: Reproductive Toxicology
Dhekra Grami, Kaïs Rtibi, Slimen Selmi, Morad Jridi, Hichem Sebai, Lamjed Marzouki, Iva Sabovic, Carlo Foresta, Luca De Toni
Medicinal plants are suggested to counteract health disorders from chemical pollutants. Here we explored the possible ameliorative effect of Eruca sativa aqueous extract (ESAE) on in vitro acute functional disturbance induced by Bisphenol A (BPA), a disruptor model in human spermatozoa. Phytochemical screening, high performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS) analysis and 2,2'-azino-bis [3-ethylbenzthiazoline-6-sulphonic acid]/α,α-diphenyl-β-picrylhydrazyl (ABTS/DPPH) tests disclosed antioxidant properties of ESAE, ascribed to polyphenols and flavonoids...
October 25, 2018: Reproductive Toxicology
Sanjay Basak, Vilasagaram Srinivas, Asim K Duttaroy
Humans are exposed to Bisphenol A (BPA) from the consumer products and plastic substances. However, impacts of low levels of BPA exposure on placental developmental processes such as first trimester trophoblast cell growth, angiogenesis and epigenetic modifications are not well studied. Low concentration of BPA (1 nM) affected cell proliferation of human placental first trimester trophoblasts using a model cell, HTR8/SVneo. BPA abolished both basal- and vascular endothelial growth factor (VEGF)-stimulated tube formation in these cells...
October 21, 2018: Reproductive Toxicology
Yingying Han, Shuhao Zhang, Ziyi Wang, Lin Zhang, Fengwei Zhang, Fangzhou Sun, Haolin Zhang, Zhengrong Yuan, Cheng Zhang, Qiang Weng
The aim of the present study was to reveal the effects of 3-methyl-4-nitrophenol (PNMC) on mouse gonadal cell proliferation and apoptosis. Immature female and male mice were intramuscularly injected with 100 mg/kg PNMC or vehicle every five days. One-month later, ovarian rather than testicular weights were significantly decreased. The positive terminal deoxyribonucleotidyl transferase-mediated dUTP-digoxigenin nick end-labelling staining was enhanced in both testicular seminiferous epithelium and ovarian corpus luteum...
October 21, 2018: Reproductive Toxicology
Jisun Yun, Young Sik Choi, Inha Lee, Young Bin Won, Jae Hoon Lee, Seok Kyo Seo, SiHyun Cho, Byung Seok Lee, Bo Hyon Yun
This retrospective study investigated and compared the incidence of congenital foetal anomalies after letrozole versus clomiphene citrate (CC) administration for infertility treatment. Data from 142 newborns were included: letrozole group, n = 83; CC group, n = 61. Congenital anomalies were found in 7.2% (6/83) patients in the letrozole group and 18.0% (11/61) patients in the CC group, with no significant between-group difference (p = .066). Major congenital anomaly rate was 2.4% (2/83) in the letrozole group and 3...
October 16, 2018: Reproductive Toxicology
Noriko Nakamura, Vikrant Vijay, Varsha G Desai, Deborah K Hansen, Tao Han, Ching-Wei Chang, Yu-Chuan Chen, Wafa Harrouk, Barry McIntyre, Paul M Foster, James C Fuscoe, Amy L Inselman
2-hydroxy-4-methoxybenzophenone (HMB) is an ultraviolet light-absorbing compound that is used in sunscreens, cosmetics and plastics. HMB has been reported to have weak estrogenic activity by in vivo and in vitro studies, making it a chemical with potential reproductive concern. To explore if prenatal and lactational HMB exposure alters gene expression profiles of the developing reproductive organs, we performed microarray analysis using the prostate and testis of postnatal day (PND) 30 male Sprague-Dawley rats offspring exposed to 0, 3000, or 30,000 ppm of HMB from gestational day 6 through PND 21...
October 11, 2018: Reproductive Toxicology
Anatoly V Skalny, Alexey A Tinkov, Tatiana G Bohan, Marina B Shabalovskaya, Olga Terekhina, Svetlana B Leshchinskaia, Lyubov A Agarkova, Svetlana V Notova, Margarita G Skalnaya, Yulia Kovas
The objective of the present study was to assess toxic and nutritional trace element and mineral status in hair of women with IVF pregnancy and their children. Inductively-coupled plasma mass-spectrometry was used to assess hair trace element levels of 50 women with IVF pregnancy and 158 controls with spontaneous pregnancy and their children. Women with IVF pregnancy were characterized by significantly elevated hair As, Hg, Li, K, Na, and reduced Fe, Si, and Zn contents. Children from IVF pregnancy had significantly lower values of hair Cr, Fe, Mg, Sr, and Al content when compared to the control values, whereas hair Hg and Mo levels were higher...
October 11, 2018: Reproductive Toxicology
Aastha Pokharel, SriDurgaDevi Kolla, Klara Matouskova, Laura N Vandenberg
The CD-1 mouse mammary gland is sexually dimorphic, with males lacking nipples. Recent studies have revealed that the underlying epithelium in the male mammary gland is sensitive to estrogenic environmental chemicals. In ongoing investigations, we observed asymmetric morphology in the left and right male mouse mammary glands. Here, we quantified these asymmetries in the embryonic, prepubertal, pubertal and adult male mammary gland. We found that the right gland was typically larger with more branching points compared to the left gland...
October 11, 2018: Reproductive Toxicology
Lynae M Brayboy, Haley Clark, Laura O Knapik, Ruby E Schnirman, Gary M Wessel
Nitrogen mustard (NM) is an alkylating chemical warfare agent, and its derivatives are used in chemotherapy. Alkylating agents can cause mitochondrial damage, so exposed females may transmit damaged genomes to their children, since mitochondria are maternally inherited and oocytes are not thought to undergo mitophagy (Boudoures et al. [1]). The objective of this study is to investigate NM's effects on oocyte mitochondria to understand risks facing female soldiers, cancer patients, and their children. Mice were injected intraperitoneally with NM, monitored for reproductive outcomes, and ovaries and oocytes were isolated for analysis...
October 9, 2018: Reproductive Toxicology
K Veltman, C Harris, Y Ahmad, O Jolliet
Precise control of the glutathione/glutathione disulfide (GSH/GSSG) redox balance is vital for the developing embryo, but regulatory mechanisms are poorly understood. We developed a novel, mechanistic mass-balance model for GSH metabolism in the organogenesis stage (gestational day 10.0-11.13) rat conceptus predicting the dynamics of 8 unique metabolites in 3 conceptal compartments: the visceral yolk sac (VYS), the extra-embryonic fluid (EEF) and the embryo proper (EMB). Our results show that thiol concentrations in all compartments are well predicted by the model...
October 5, 2018: Reproductive Toxicology
Mo Chen, Li-Yi Cai, Saishu Yoshida, Susumu Takekoshi, Hiroshi Kajiwara, Naoto Nishimura, HongHua Wang, Takako Kato, Shun-Ichiro Izumi, Yukio Kato
Infection with human herpes virus 1 (HHV1) is a suspected cause of human male infertility. However, the correlation between HHV1 infection and infertility is still unclear. We have previously generated transgenic rats that ectopically express the HHV1 thymidine kinase gene (HHV1-TK) in post-meiotic spermatids and found they had aberrant spermatogenesis and infertility. Therefore, we hypothesized that human infertility might be caused by HHV1 infection. Here, we examined whether HHV1-TK is expressed in human testis by analyzing the presence of its transcript and protein...
September 30, 2018: Reproductive Toxicology
Hanna Katarina Lilith Johansson, Camilla Lindgren Schwartz, Lene Nørby Nielsen, Julie Boberg, Anne Marie Vinggaard, Martin Iain Bahl, Terje Svingen
Glyphosate has been suggested to be an endocrine disrupting chemical capable of disrupting male reproduction. There are conflicting data, however, with studies reporting effects from exposure to either glyphosate alone or to herbicide formulations, making comparisons difficult. We assessed rat testis histopathology and androgen function following two weeks exposure to either glyphosate at 2.5 and 25 mg/kg bw/day (5x and 50x Acceptable Daily Intake, ADI, respectively), or equivalent high dose of glyphosate in a herbicide formulation; Glyfonova...
September 27, 2018: Reproductive Toxicology
Aleksandra Konieczna, Dominik Rachoń, Katarzyna Owczarek, Paweł Kubica, Agnieszka Kowalewska, Błażej Kudłak, Andrzej Wasik, Jacek Namieśnik
The aim of this study was to determine serum bisphenol A (BPA) concentrations using high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS) in women with polycystic ovary syndrome (PCOS) (n = 106, age range 18-40 yrs) and to evaluate its potential impact on their hormonal and metabolic profile. The control group consisted of age- and BMI-matched 80 eumenorrheic women with no clinical or biochemical hyperandrogenism. Our results showed that women with PCOS had significantly higher serum BPA concentrations than healthy controls (geometric mean and [95% CI]: 0...
September 25, 2018: Reproductive Toxicology
Rachel Ion, Claire Hudson, Jason Johnson, Wei Yuan, Kate Heesom, Andrés López Bernal
INTRODUCTION: The way in which tobacco smoking increases the risk of preterm labor remains uncertain. Altered prostaglandin metabolism is one potential mechanism. METHODS: Proteins in fetal membrane samples (amniochoriodecidua) from 20 women were relatively quantified using Tandem Mass Tagging nano-liquid chromatography mass spectrometry. RESULTS: Prostaglandin synthases and two enzymes involved in prostaglandin degradation, hydroxyprostaglandin dehydrogenase (HPGD) and CBR1, were detected by the mass spectrometer...
September 21, 2018: Reproductive Toxicology
Won-Hee Song, Elsayed A Mohamed, Won-Ki Pang, Kyu-Ho Kang, Do-Yeal Ryu, Md Saidur Rahman, Myung-Geol Pang
Although equal numbers of X and Y spermatozoa are produced during spermatogenesis, the sex chromosome ratio in ejaculated spermatozoa can be altered by exposure to endocrine-disrupting chemicals (EDCs), which can be reflected by altered sex ratios at birth. Here, we hypothesized EDCs affect sperm functions and viability of X and Y chromosome-bearing human spermatozoa. After exposure to genistein (Gen), bisphenol A (BPA), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dibromochloropropane (DBCP), and diazinon (Diaz), we evaluated motility, viability, capacitation, and differential viability of X and Y spermatozoa...
September 13, 2018: Reproductive Toxicology
Ruth J Geller, Rebecca M Brotman, Katie M O'Brien, Derek M Fine, Ami R Zota
Endocrine-disrupting chemicals, such as phthalates, are an unexamined potential risk factor for bacterial vaginosis (BV) and warrant investigation because hormones affect BV. We examined the association between phthalate exposure and BV in the National Health and Nutrition Examination Survey, 2001-2004. BV outcomes were defined as intermediate (Nugent score of 4-6) and positive (7-10). Phthalate metabolites, including monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), and di(2-ethylhexyl) phthalate (DEHP) metabolites, were measured in urine...
September 9, 2018: Reproductive Toxicology
Daniel G Cyr, Mary Gregory
No abstract text is available yet for this article.
August 30, 2018: Reproductive Toxicology
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