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Reproductive Toxicology

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https://www.readbyqxmd.com/read/28526456/combined-exposure-to-low-doses-of-pesticides-causes-decreased-birth-weights-in-rats
#1
Ulla Hass, Sofie Christiansen, Marta Axelstad, Martin Scholze, Julie Boberg
Decreased birth weight is a common effect of many pesticides in reproductive toxicity studies, but there are no empirical data on how pesticides act in combination on this endpoint. We hypothesized that a mixture of six pesticides (cyromazine, MCPB, pirimicarb, quinoclamine, thiram, and ziram) would decrease birth weight, and that these mixture effects could be predicted by the Dose Addition model. Data for the predictions were obtained from the Draft Assessment Reports of the individual pesticides. A mixture of equi-effective doses of these pesticides was tested in two studies in Wistar rats, showing mixture effects in good agreement with the additivity predictions...
May 16, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28501545/betamethasone-causes-intergenerational-reproductive-impairment-in-male-rats
#2
Cibele Dos Santos Borges, Taina Louise Pacheco, Katiussia Pinho da Silva, Fábio Henrique Fernandes, Mary Gregory, André Sampaio Pupo, Daisy Maria F Salvadori, Daniel G Cyr, Wilma De G Kempinas
Prenatal betamethasone (BM) exposure in rats negatively impacts sperm quality and male fertility. Studies have shown that BM can cause multi-generational effects on the pituitary-adrenal-axis of rats. The objective of this study was to assess the reproductive development and fertility of male rats (F2) whose fathers (F1) were exposed to BM (0.1mg/kg) on gestational days 12, 13, 18 and 19. In F2 rats, there was a significant reduction in body weights of the BM-treated group at PND 1 as well as delayed onset of puberty, and decreases in FSH levels, Leydig cell volume, sperm number and motility, seminal vesicle contractility and ejaculated volume...
May 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28499744/does-prednisone-use-or-disease-activity-in-pregnant-women-with-rheumatoid-arthritis-influence-the-body-composition-of-their-offspring
#3
Florentien Deirdre Olivia de Steenwinkel, Radboud J E M Dolhain, Johanna M W Hazes, Anita C S Hokken-Koelega
Glucocorticoids are given during pregnancy when rheumatoid arthritis (RA) is too active. It could lead to increased risk of cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM) in the offspring. Elevated RA disease activity during pregnancy is associated with low birth weight and rapid post-natal growth. Both can negatively influence the body composition later in life. This study shows that prednisone use or RA disease activity in pregnant women with RA had no influence on the body composition of prepubertal offspring...
May 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28495514/neurobehavioral-risks-of-ssris-in-pregnancy-comparing-human-and-animal-data
#4
REVIEW
Asher Ornoy
During the last twenty years, in spite of extensive literature regarding the use of SSRIs in pregnancy, confusion still exists as to possible long-term risks of these drugs on the offspring. Possible negative effects relate to neurodevelopmental outcome and association with Autism Spectrum Disorder (ASD). Most neurodevelopmental follow up studies did not find significant cognitive impairment except from some apparently transient, gross motor delay and slight impairment of language abilities. The literature on the possible association of SSRIs with ASD is inconsistent, and if an association exists it is apparently throughout pregnancy...
May 8, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28479404/association-of-reproductive-disorders-and-male-congenital-anomalies-with-environmental-exposure-to-endocrine-active-pesticides
#5
Jessica García González, María Isabel Ventura Miranda, Mar Requena Mullor, Antonio F Hernández Jerez, Tesifón Parrón Carreño, Raquel Alarcón Rodriguez
There is growing evidence that environmental exposure to pesticides may increase the risk of developing reproductive and developmental disorders. This study determined the prevalence and risk of developing gestational disorders and male congenital genitourinary malformations in areas with distinct exposure to pesticides, many of them with potential endocrine disrupting properties. A population-based case-control study was carried out on pregnant women and male children living in ten health districts of Andalusia classified as areas of high and low environmental exposure to pesticides according to agronomic criteria...
May 4, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28478049/leflunomide-a-human-teratogen-a-still-not-answered-question-an-evaluation-of-the-german-embryotox-pharmacovigilance-database
#6
Corinna Weber-Schoendorfer, Evelin Beck, Tatjana Tissen-Diabaté, Christof Schaefer
The teratogenic potential of leflunomide (LEF) in humans is still a matter of debate. We evaluated exposed pregnancies of our German Embryotox pharmacovigilance database. Inclusion criteria were LEF exposure anytime between 2 years before and 10 weeks after conception and no wash-out therapy before pregnancy. Of 65 prospectively enrolled pregnancies 47 were exposed during the 1st trimester and 18 preconceptional. Wash-out therapy was confirmed in 25 pregnancies. There were 10 spontaneous abortions and 19 elective terminations...
May 3, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28476547/bisphenol-a-exposure-in-utero-programs-a-sexually-dimorphic-estrogenic-state-of-hepatic-metabolic-gene-expression
#7
Ysabel Ilagan, Ramanaiah Mamillapalli, Laura G Goetz, Jehanzeb Kayani, Hugh S Taylor
Bisphenol-A (BPA) exposure in utero affects fetal development and metabolism leading to obesity. However, the mechanisms are not well characterized. We identified sexually dimorphic developmental programming of genes regulating metabolism in the liver after BPA exposure. Pregnant mice were treated with BPA on days 9-18 of gestation. At six weeks, female offspring were ovariectomized; both sexes were subsequently treated with estradiol (E2). Fetal BPA exposure altered the expression of genes in liver, including those involved in glucose and lipid metabolism, and transporters, in both sexes...
May 2, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28461243/current-perspective-of-diethylstilbestrol-des-exposure-in-mothers-and-offspring
#8
REVIEW
Taher Al Jishi, Consolato Sergi
Diethylstilbestrol (DES) was an orally active estrogen prescribed to the pregnant women to prevent miscarriages. DES is known as a 'biological time bomb' and long-term effects of DES have been recorded in the mothers exposed to DES and their offspring (DES-daughters and DES-sons). Adverse pregnancy outcomes, infertility, cancer, and early menopause have been discovered in women exposed to DES, and some events occur in their offspring and subsequent generations. An increased risk of breast cancer is not limited to the DES-exposed daughters...
April 28, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28461242/genistein-crosses-the-bioartificial-oviduct-and-alters-secretion-composition
#9
Constantine A Simintiras, Roger G Sturmey
The dietary derived isoflavone and oestrogen analogue, genistein, is known to perturb fundamental reproductive events such as implantation and embryo cleavage. However the question of whether genistein is able to traverse the oviduct epithelial monolayer and impact oviduct fluid secretion remains unclear. This study tests these research questions using a bioartificial oviduct to show that genistein permeates the oviduct lumen in vitro with a biphasic (burst and plateau) kinetic profile, faster than spontaneous diffusion, and alters the amino acid composition of in vitro derived oviduct fluid (ivDOF) but not as an oestrogen analogue...
April 28, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28461241/factors-associated-with-mercury-levels-in-human-placenta-and-the-relationship-to-neonatal-anthropometry-in-jamaica-and-trinidad-tobago
#10
Phylicia Ricketts, Horace Fletcher, Mitko Voutchkov
The aim of this study was to investigate the mercury levels in human placenta and its relationship to neonatal anthropometry for a group of selected pregnant women in Kingston and Manchester in Jamaica and St. Joseph in Trinidad & Tobago. The participants were interviewed on their fish intake. Neonatal anthropometric data were also recorded. The placental mercury concentrations ranged from 0.64±0.5μg/kg to 1.4±0.6μg/kg. The most significant associated factor for prenatal mercury exposure was maternal fish intake...
April 28, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28431984/thyroid-disrupting-pesticides-impair-the-hypothalamic-pituitary-testicular-axis-of-a-wildlife-bird-amandava-amandava
#11
Banalata Mohanty, Surya Prakash Pandey, Kazuyoshi Tsutsui
The effect of two thyroid disrupting pesticides (TDPs) mancozeb (MCZ) and imidacloprid (IMI) on the hypothalamic-pituitary-gonadal/testicular (HPG) axis of a seasonally breeding bird, Amandava amandava has been evaluated. Male birds (n=8/group) were exposed to each of the pesticide (0.25% LD50 of respective pesticide) as well as to their two equimixture doses (0.25% of LD50 of each and 0.5% LD50 of each) through food for 30d during pre-breeding stage of the reproductive cycle. Reduction in weight, volume and other histopathological features revealed testicular regression...
April 19, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28431985/quercetin-interferes-with-the-fluid-volume-and-receptivity-development-of-the-uterus-in-rats-during-the-peri-implantation-period
#12
Huma Shahzad, Nelli Giribabu, Kamarulzaman Karim, Normadiah Kassim, Sekaran Muniandy, Kilari Eswar Kumar, Naguib Salleh
HYPOTHESIS: Quercetin could induce changes to the fluid volume and receptivity development of the uterus during peri-implantation period. METHODS: Female rats were treated with quercetin (10, 25 and 50mg/kg/day) subcutaneously beginning from day-1 pregnancy. Uterus was harvested at day-4 (following three days quercetin treatment) for morphological, ultra-structural, protein and mRNA expressional changes and plasma sex-steroid levels analyses. In another cohort of rats, implantation rate was determined at day-6 (following five days quercetin treatment)...
April 18, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28428071/development-of-novel-in-silico-model-for-developmental-toxicity-assessment-by-using-na%C3%A3-ve-bayes-classifier-method
#13
Hui Zhang, Ji-Xia Ren, Yan-Li Kang, Peng Bo, Jun-Yu Liang, Lan Ding, Wei-Bao Kong, Ji Zhang
Toxicological testing associated with developmental toxicity endpoints are very expensive, time consuming and labor intensive. Thus, developing alternative approaches for developmental toxicity testing is an important and urgent task in the drug development filed. In this investigation, the naïve Bayes classifier was applied to develop a novel prediction model for developmental toxicity. The established prediction model was evaluated by the internal 5-fold cross validation and external test set. The overall prediction results for the internal 5-fold cross validation of the training set and external test set were 96...
April 18, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28414088/embryonic-vascular-disruption-adverse-outcomes-linking-high-throughput-signaling-signatures-with-functional-consequences
#14
Robert G Ellis-Hutchings, Raja S Settivari, Alene T McCoy, Nicole Kleinstreuer, Jill Franzosa, Thomas B Knudsen, Edward W Carney
Embryonic vascular disruption is an important adverse outcome pathway (AOP) as chemical disruption of cardiovascular development induces broad prenatal defects. High-throughput screening (HTS) assays aid AOP development although linking in vitro data to in vivo apical endpoints remains challenging. This study evaluated two anti-angiogenic agents, 5HPP-33 and TNP-470, across the ToxCastDB HTS assay platform and anchored the results to complex in vitro functional assays: the rat aortic explant assay (AEA), rat whole embryo culture (WEC), and the zebrafish embryotoxicity (ZET) assay...
April 13, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28410833/boberg-et-al-2011-corrigendum-2016-further-significant-modifications-needed
#15
LETTER
Peter Morfeld, Min Chen, Rainer Otter, Christine Palermo, Jessica Kemmerling, Michela Mastrantonio
No abstract text is available yet for this article.
April 11, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28408308/effect-of-lipopolysaccharide-on-developmental-competence-of-oocytes
#16
Fumie Magata, Takashi Shimizu
In postpartum dairy cows, lipopolysaccharide (LPS) derived from gram-negative bacteria such as Escherichia coli causes uterine inflammation resulting in low fertility. The aim of this study was to determine the effect of LPS on the developmental competence of bovine oocytes in vitro. LPS perturbed the nuclear maturation of bovine oocytes by inhibiting meiotic progression. Although LPS did not affect the copy number of mitochondrial DNA, it decreased mitochondrial membrane potential in matured oocytes. LPS inhibited mitochondrial redistribution throughout the cytoplasm...
April 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28400286/increased-oxidative-stress-and-cytokinesis-block-micronucleus-cytome-assay-parameters-in-pregnant-women-with-gestational-diabetes-mellitus-and-gestational-arterial-hypertension
#17
Mina Toljic, Amira Egic, Jelena Munjas, Natasa Karadzov Orlic, Zagorka Milovanovic, Aleksandra Radenkovic, Jovana Vuceljic, Ivana Joksic
We investigated whether gestational diabetes mellitus (GDM) and gestational arterial hypertension (GH) are associated with increased oxidative stress and DNA damage. Study included 3 groups of pregnant women (GDM, GH and control). DNA damage biomarkers (micronuclei MNi, nucleoplasmic bridges NPBs and nuclear buds NBUDs) were assessed by cytokinesis-block micronucleus cytome assay. Oxidative stress levels were evaluated by analyzing malondialdehyde equivalents (TBARS) and 8-hydroxy-2'-deoxyguanosine (8-OHdG)...
April 8, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28392050/rebuttal-to-letter-by-morfeld-et-al-boberg-et-al-2011-corrigendum-2016-further-significant-modifications-needed
#18
LETTER
J Boberg, M Axelstad, S Christiansen, U Hass
No abstract text is available yet for this article.
April 6, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28366586/intramuscularly-administered-herpes-zoster-subunit-vaccine-has-no-effects-on-fertility-pre-and-post-natal-development-in-sprague-dawley-rats
#19
Lawrence Segal, Karen Thacker, Michel Fochesato, Giulia Giordano, Nathalie Garçon, Eric Destexhe
The herpes zoster subunit vaccine (HZ/su) is an investigational vaccine for the prevention of shingles, a disease caused by the varicella zoster virus (VZV). It is composed of recombinant VZV glycoprotein E (gE) and AS01. We assessed the potential toxic effects of gE/AS01 and AS01 alone on female and male fertility, and on embryo-fetal, pre- and post-natal development in Sprague-Dawley rats. Females were immunized before pairing and during gestation. Half of the pregnant rats were used for embryo-fetal investigations...
March 31, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28341573/quercetin-alters-uterine-fluid-volume-and-aquaporin-aqp-subunits-aqp-1-2-5-7-expression-in-the-uterus-in-the-presence-of-sex-steroids-in-rats
#20
Huma Shahzad, Nelli Giribabu, Kamarulzaman Karim, Sekaran Muniandy, Normadiah M Kassim, Naguib Salleh
Effects of quercetin on uterine fluid volume and aquaporin (AQP) expression in the uterus were investigated. Estradiol (E) or estradiol followed by progesterone (E+P) were given to ovariectomised rats with or without quercetin (10, 50 or 100mg/kg/day) treatment. Uteri were harvested and its inner/outer circumference ratio was determined. AQP-1, 2, 5 and 7 mRNA and protein levels in uterus were quantified by Real-time PCR and Western blotting respectively. Protein distribution was observed by immunohistochemistry...
March 22, 2017: Reproductive Toxicology
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