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APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica

Hadi Rezaeeyan, Reza Shirzad, Trevor D McKee, Najmaldin Saki
Chemokines are cytokines that are involved in the movement of leukocytes and the occurrence of immune responses. It has recently been noted that these cytokines play a role in the movement of cancer cells to different parts of the body and create a suitable environment [i.e. (pre) metastatic niche] for their growth and proliferation. We studied the role of chemokines in the metastasis of cancer cells, as well as their involvement in the proliferation and growth of these cells. Relevant literature was identified by a PubMed search (2005-2017) of English language papers using the terms 'chemokine,' 'metastasis niche,' and 'organotropism...
April 20, 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Karolin Froehlich, Hanne Stensheim, Udo R Markert, Gitta Turowski
Breast cancer is one of the most common malignancies diagnosed in pregnancy. Although the tumor is often detected at an advanced stage, placental metastases are rare. Here, we describe the case of a woman with breast cancer recurrence during pregnancy and subsequent metastases. The focus of this study is the large amount of placenta metastases, which have been analyzed immunohistochemically. Staining with trophoblast markers (placenta alkaline phosphatase, beta human chorionic gonadotropin and human placental lactogen) showed the strict localization of metastases in the intervillous space without invasion into fetal tissue...
April 17, 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Hui-Wen Tseng, Hui-Hwa Tseng, Huei-Han Liou, Kuo-Wang Tsai, Luo-Ping Ger, Yow-Ling Shiue
The aim of this study was to investigate the associations among the immunoexpression levels of manganese superoxide dismutase (Mn-SOD), glutathione peroxidase (GPx), and myeloperoxidase (MPO) in lip squamous cell carcinoma (LSCC) tissues and the clinicopathological characteristics, and prognostic factors in patients with LSCC. The immunoexpression levels of Mn-SOD, GPx, and MPO were examined in 76 LSCC tissue samples using immunohistochemical staining on tissue microarray slides, and compared to those in normal lip mucosa adjacent to venous lakes (normal controls), normal tissue adjacent to corresponding tumors (NTACT), and recurrent tumors...
April 6, 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Susanne Jacobsson, Bianca Stenmark, Sara Thulin Hedberg, Paula Mölling, Hans Fredlund
The aims of the study were to estimate the carrier state of Neisseria meningitidis in Swedish teenagers and its association with an outbreak at the World Scout Jamboree in 2015 as well as to compare sensitivity of throat versus nasopharyngeal swab for optimal detection of carriage. In total, 1 705 samples (cultures n = 32, throat swabs n = 715, nasopharyngeal swabs n = 958) from 1 020 Jamboree participants were collected and sent to the National Reference Laboratory for Neisseria meningitidis for culture and molecular analysis...
March 15, 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Saeid Fathi, Fatemeh Jalousian, Seyed Hossein Hosseini, Ali Najafi, Enayat Darabi, Faramarz Koohsar
The immunodiagnostic tests for cystic echinococcosis (CE) are mostly serological tests based on ELISA that use hydatid cyst antigens for primary screening because of its simple preparation and availability. The challenge to develop new serological methods (as compared to those based on the hydatid cyst fluid antigens) to meet the gold standard remains. Appropriate sources of antigenic material are necessary for application to improve the efficacy of immunodiagnostic tests at a population level. In the current study, a fusion protein containing the coding sequence of antigen B2t and two sequences of EPC1 antigen with some modifications was reconstructed...
May 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Kirsi Gröndahl-Yli-Hannuksela, Emilia Lönnqvist, Teemu Kallonen, Laura Lindholm, Jari Jalava, Kaisu Rantakokko-Jalava, Jaana Vuopio
Colistin resistance mediated by mobile mcr-1 gene has raised concern during the last years. After steep increase in mcr-1 reports, other mcr-gene variants (mcr-2 to mcr-5) have been revealed as well. In 2016, a clinical study was conducted on asymptomatic stool carriage of extended spectrum beta-lactamase (ESBL) producing Escherichia coli and Klebsiella pneumoniae among Finnish adults. All suspected ESBL producing bacterial isolates were first tested by phenotypic ESBL-confirmation methods, and then further analyzed with whole genome sequencing to identify the resistance genes...
May 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Mohamed A Soliman, Mohamed A Helwa, Samar K Fath-Allah, Mahmoud A El-Hawy, Hassan S Badr, Naglaa Fathy Barseem
The aim is to study IL-10 polymorphisms and IL-10 level and assess their relation to T-cell subsets in childhood immune thrombocytopenia (ITP). In all, 40 (25 acute, 15 chronic) ITP child patients were investigated at time of presentation, compared to 15 healthy, age- and gender-matched controls and followed up for 1 year to determine chronic cases. Studying the effect of IL-10 promoter polymorphism was done by PCR-RFLP, IL-10 level was determined by ELISA, natural killer cells and T-cell subsets were evaluated by flow cytometry...
May 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Søren Ohrt-Nissen, Blaine G Fritz, Jonas Walbom, Kasper N Kragh, Thomas Bjarnsholt, Benny Dahl, Claus Manniche
A relationship has been suggested between lumbar disc herniation (LDH) and chronic bacterial infection frequently involving Propionibacterium acnes, which is known to cause chronic infection through the formation of biofilm aggregates. The objective of the study was to assess whether a disc infection involving biofilm formation is present in patients with LDH. A total of 51 LDH patients and 14 controls were included. Bacterial DNA was detected by real-time polymerase chain reaction (PCR) in 16/51 samples in the LDH group and 7/14 controls (p = 0...
May 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Päivi Jalava-Karvinen, Juha O Grönroos, Helena Tuunanen, Jukka Kemppainen, Jarmo Oksi, Ulla Hohenthal
We describe a rare case of prosthetic valve endocarditis caused by the canine bacterium Capnocytophaga canimorsus in a male aged 73 years. The diagnosis of infective endocarditis was unequivocal, as it blood cultures were positive for C. canimorsus and vegetations were detected on transesophageal echocardiography; the modified Duke criteria were fulfilled. PET-CT showed intense 18 F-FDG uptake of the prosthetic valve area. The patient was treated with antibiotics alone (no surgery), and is now on life-long suppressive antibiotic therapy...
May 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Katia C Sibin Melo, Marcelo H Correia, Terezinha I E Svidzinski, Luzmarina Hernandes
The skin is an important gateway for Fusarium infection in humans. Our hypothesis is that metabolites produced by Fusarium oxysporum should change the barrier structure to permeate the skin. Male Wistar rats received a topical application of a solution (0.05 mg/mL) of Fusarium metabolites. The animals were euthanized 3, 6, 12, 24 h after and the skin was processed for immunostaining by laminin and E-cadherin to investigate whether the Fusarium metabolites can break the barrier of healthy skin. Other techniques were employed: H&E to study the morphology; metalloproteinase-9 (MMP-9), TUNEL, and PCNA immunostaining to evaluate the inflammation, cell death, and proliferation, respectively...
May 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Gamze Guney Eskiler, Gulsah Cecener, Unal Egeli, Berrin Tunca
Treatment of triple negative breast cancer (TNBC) is a clinically challenging problem due to intriguing clinical and pathologic features of TNBC and natural or induced resistance to existing therapies. However, a great understanding of features of TNBC particularly associated with BRCA mutations has led to the development of different therapeutic approaches. Besides, identification of TNBC subtypes contribute to investigation of the underlying molecular differences and development of new strategies for the treatment of TNBC patients...
May 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Rui Cheng, Yongqin Chen, Haohui Zhou, Bi Wang, Qiang Du, Yanling Chen
This study was designed to explore the expression of B7-H3 in human intrahepatic cholangiocarcinoma (ICC) and its association with the clinicopathologic factors. In the current study, the expression of B7-H3 in 45 patients with intrahepatic cholangiocarcinoma and 8 patients with hepatolithiasis was analyzed by immunohistochemistry, which revealed that B7-H3 was not expressed in hepatolithiatic tissues, but positively expressed in 57.8% (26/45) of the ICC cases. The expression of B7-H3 was significantly associated with lymph node metastases and venous invasion...
May 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Eduardo Henrique Cunha Neves Filho, Adriana Pinheiro Bezerra Pires, Rosane Oliveira de Sant'Ana, Silvia Helena Barem Rabenhorst, Carlos Gustavo Hirth, Maria Do Perpétuo Socorro Saldanha da Cunha
Although the introduction of the perioperative chemotherapy on the management of gastric cancer has improved patients survival, heterogeneity of clinical outcomes has been evidenced in parallel to different histopathological regression pattern of gastric cancer cells. Thus, this study evaluated the tumor regression grading (TRG) in a series of post-treatment gastric tumors and its associations with HER2, MET, and FOXP3 expression. Material of 54 gastric cancer samples was available for TRG evaluation and immunohistochemistry...
May 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Andres M Acosta, Mohamed R Haroon Al Rasheed, Haoliang Xu, Christine Salibay, Michael R Pins
Sebaceous carcinoma of the breast (SCB) is a rare variant of ductal carcinoma arising within the mammary gland and containing at least 50% of malignant cells with sebaceous differentiation. Only 11 cases that adjust to the criteria delineated in the WHO classification have been published in the English literature, to the best of our knowledge. Here, we present the first SCB arising in the context of a deleterious BRCA2 mutation, focusing on the histopathologic and immunohistochemical features of this exceedingly rare tumor...
April 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Azin Samimi, Heybatullah Kalantari, Marzieh Zeinvand Lorestani, Reza Shirzad, Najmaldin Saki
Leukemia is developed following the abnormal proliferation of immature hematopoietic cells in the blood when hematopoietic stem cells lose the ability to turn into mature cells at different stages of maturation and differentiation. Leukemia initiating cells are specifically dependent upon the suppression of oxidative stress in the hypoglycemic bone marrow (BM) environment to be able to start their activities. Relevant literature was identified by a PubMed search (2000-2017) of English-language literature using the terms 'oxidative stress,' 'reactive oxygen species,' 'hematopoietic stem cell,' and 'leukemia...
April 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
HariOm Singh, Dharmesh Samani, Nayana Nambiar, Manisha V Ghate, R R Gangakhedkar
Remodeling of extracellular matrix (ECM) by matrix metalloproteinases (MMPs) is a presumed reason for the development of HIV-associated neurocognitive disorders (HAND). The coding region polymorphism in MMP-21 572C/T gene may have a potential functional effect on ECM remodeling. Hence, we aimed to examine the association of MMP-21 polymorphism with the modulation of HAND severity and its prevalence in HIV-infected and healthy individuals. Genotyping of MMP-21 572C/T polymorphism was performed by PCR-RFLP in total 150 HIV-infected individuals, 50 with HAND, 100 without HAND and 150 healthy controls...
April 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Elham Maleki, Kamran Ghaedi, Kahin Shahanipoor, Zana Karimi Kurdistani
miR-19b (miR-19b-3p) has been reported to be correlated with either favorable or unfavorable events in several cancers. However, no study has been conducted to evaluate the expression level of miR-19b in patients with breast cancer (BC). This study was aimed to investigate the expression level of miR-19b in human malignant and healthy breast tissues with histopathology of ER+/PR+/HER2-. We performed a miRNA real-time PCR to detect differential expression of miR-19b in 40 BC, including 17 BC with familial background and 23 BC without familial background, and 12 non-tumoral tissues...
April 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Alexandros Iliadis, Maria-Aikaterini Virvili, Nicolaos A Flaris, Stavroula Pervana, Elissabet Pazarli, Grigoris Tripsianis, Maria E Grigoriou, Ioannis Efstratiou, Dimitrios N Kanakis
This study essentially aims to contribute to the immunohistochemical investigation of the use of pituitary tumor transforming gene (PTTG) as a marker of cell proliferation or advanced tumor grade in meningiomas of various WHO grades. In all, 51 cases were recovered in total, 21 Grade-I, 23 Grade-II and 7 Grade-III meningiomas. Mitotic index (MI), Ki-67/MiB-1 positivity percentage and PTTG expression were analyzed in correlation to each other as well as to the tumor WHO grades. All three biomarkers showed a high diagnostic significance and a strong association with WHO grades...
April 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Randolf Hardersen, Terje Enebakk, Dorte Christiansen, Grethe Bergseth, Ole-Lars Brekke, Tom Eirik Mollnes, Knut Tore Lappegård, Anders Hovland
The aim of the study was to investigate the role of complement factor 5 (C5) in reactions elicited by plasma separation using blood from a C5-deficient (C5D) individual, comparing it to C5-deficient blood reconstituted with C5 (C5DR) and blood from healthy donors. Blood was circulated through an ex vivo plasma separation model. Leukocyte CD11b expression and leukocyte-platelet conjugates were measured by flow cytometry during a 30-min period. Other markers were assessed during a 240-min period. Granulocyte and monocyte CD11b expression did not increase in C5D blood during plasma separation...
April 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Taher Azimi, Mohammad Javad Nasiri, Alireza Salimi Chirani, Ramin Pouriran, Hossein Dabiri
Inflammatory bowel disease (IBD) is a general term used for the ulcerative colitis (UC) and Crohn's disease (CD); in addition, IBD principally refers to a chronic disease of the gastrointestinal tract in which mediated by immune system. Consequently, IBD could progress in individuals who are genetically prone. Infections role in the development of inflammatory disease of the gastrointestinal tract has been studied by quite many clinical studies; furthermore, the possible role of some pathogens in the development and exacerbation of the inflammatory disease of the gastrointestinal tract have been described...
April 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
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