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APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica

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https://www.readbyqxmd.com/read/30397964/early-depletion-of-contact-system-in-patients-with-sepsis-a-prospective-matched-control-observational-study
#1
Ingrid Berkestedt, Pia Andersson, Heiko Herwald, John Karlsson Valik, Ola Sörensen, Mikael Bodelsson
Activation of the contact system generates bradykinin from high-molecular-weight kininogen and has been suggested to participate in the pathophysiology of sepsis. To test this, we prospectively measured bradykinin and high-molecular-weight kininogen levels in a cohort of sepsis patients requiring intensive care. From 29 patients meeting criteria for sepsis or septic shock according to Sepsis-3, blood was sampled within 24 h and on the fourth day following admittance to intensive care. Patients planned for neurosurgery served as matched controls...
November 5, 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30378168/maternal-and-congenital-cytomegalovirus-infections-in-a-population-based-pregnancy-cohort-study
#2
Regine Barlinn, Susanne G Dudman, Lill Trogstad, Moustafa Gibory, Fredrik Muller, Per Magnus, Halvor Rollag
CMV is the most common cause of congenital infection. During the past few decades, there has been a change in behaviour that possibly has affected the CMV infection rate of mother and child. We investigated 1350 randomly selected pregnant women from the Norwegian Mother and Child Cohort Study using an algorithm for detection of maternal and congenital CMV (cCMV) infection including both serology and nucleic acid amplification assay. The CMV IgG seroprevalence was 54% and 23 (3.7%) mothers seroconverted. Three (0...
October 30, 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30357962/toll-like-receptors-2-4-and-9-and-hypoxia-markers-hif-1alpha-and-caix-in-pancreatic-intraepithelial-neoplasia
#3
Joni Leppänen, Olli Helminen, Heikki Huhta, Joonas H Kauppila, Joel Isohookana, Kirsi-Maria Haapasaari, Peeter Karihtala, Seppo Parkkila, Juha Saarnio, Petri P Lehenkari, Tuomo J Karttunen
Pancreatic cancer arises from precursor lesions called pancreatic intraepithelial neoplasia (PanIN) characterized by inflammatory microenvironment. In pancreatic cancer, strong innate immunity and hypoxia responses are typical. Occurrence and relationship of these responses in human PanINs is unknown. We have studied the expression of toll-like receptors (TLR) TLR2, TLR4 and TLR9, and hypoxia markers HIF-1alpha and Carbonic anhydrase IX (CAIX) in normal and inflamed pancreatic ducts, in PanINs and in cancers...
November 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30357961/bartonella-quintana-past-present-and-future-of-the-scourge-of-world-war-i
#4
REVIEW
Joaquim Ruiz
During World War I, a mysterious new disease affected soldiers on both sides of battle field. The first reports described a relapsing fever of unknown origin with body lice being suggested as the vector. The outbreak affected >1 000 000 people, mostly soldiers fighting in front-line trenches. Shortly afterward, the illness was known as Trench fever, of which the causal infectious agent is currently classified as Bartonella quintana.
November 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30357960/replicon-typing-of-plasmids-in-environmental-achromobacter-sp-producing-quinolone-resistant-determinants
#5
João Pedro Rueda Furlan, Danilo Garcia Sanchez, Inara Fernanda Lage Gallo, Eliana Guedes Stehling
This study aimed to investigate the antimicrobial resistance profile to quinolones, the presence of quinolone-resistant determinants and the plasmid replicon typing in environmental Achromobacter sp. isolated from Brazil. Soil and water samples were used for bacterial isolation. The antimicrobial susceptibility testing was performed by minimum inhibitory concentration method. The detection of mutations in the quinolone resistance-determining regions (QRDR) genes, the presence of plasmid-mediated quinolone resistance (PMQR) genes, and plasmid replicons were performed by PCR...
November 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30357959/a-fatal-case-of-enterovirus-infection-with-secondary-hemophagocytosis-case-report-with-review-of-literature
#6
REVIEW
Manoj Gopal Madakshira, Sunny Bhardwaj, Kirti Gupta, Yogesh Chander, Ashish Bhalla
Enterovirus is a common viral infection, which can affect multiple organ systems with an array of clinical presentation such as meningitis, encephalitis, myocarditis, and disseminated infections. The illness is usually asymptomatic and self-limited but few cases can be severe and life-threatening especially when associated with hemophagocytosis. We discuss a fatal case of disseminated enterovirus infection and the histomorphological features of the infection.
November 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30357958/rapid-antimicrobial-susceptibility-testing-of-positive-blood-cultures-by-direct-inoculation-and-reading-of-disc-diffusion-tests-after-3-4-hours
#7
Einar Tollaksen Weme
The aim of the study was to validate whether rapid antimicrobial susceptibility testing (AST) by very early reading of disc diffusion tests would provide reliable results in daily routine work. A total of 264 positive blood culture bottles were examined, of which 178 were examined as part of the daily routine workflow. Enterobacterales were evaluated for resistance to cefotaxime, ceftazidime, gentamicin and ampicillin. Staphylococcus aureus (S. aureus) was tested for resistance to cefoxitin as a marker of methicillin-resistant S...
November 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30357957/prevalence-of-cyp2d6-4-1934g-a-polymorphism-in-western-indian-hiv-patients
#8
HariOm Singh, Sonam Lata, Raman R Gangakhedkar
Hepatic CYP2D6 enzyme metabolizes antiretroviral drugs (ARVs) including nevirapine. Polymorphism in CYP2D6 gene affects drug metabolism and displays distinctive phenotypes in the population. Hence, we investigated the prevalence of CYP2D6*4 1934G/A polymorphism in a total of 165 HIV patients that include 34 with and 131 without hepatotoxicity and 160 unrelated healthy controls by the PCR-RFLP method. The prevalence of CYP2D6*4 1934AA genotype was higher in total HIV patients as compared to healthy controls (1...
November 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30324693/clinicopathological-features-of-hydrophilic-polymer-emboli-in-japanese-autopsy-cases
#9
Masashi Miyaoka, Kazuhito Hatanaka, Toshimasa Uekusa, Naoya Nakamura
Hydrophilic polymer is used on multiple endovascular devices to decrease friction between these devices and vessel walls. Although it can prevent medical device-related complications, hydrophilic polymer emboli (HPE) has recently been established as a potentially fatal iatrogenic phenomenon. HPE can cause tissue injury in numerous sites, including the brain, heart, lung, skin, and intestines. Most HPE reports have been from Europe and the USA. Therefore, we investigated the frequency, site distribution, and degree of tissue injury of HPE in 227 Japanese autopsy cases...
November 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30264432/medical-and-dental-applications-of-nanomedicines
#10
REVIEW
Fraidoon Kavoosi, Farzan Modaresi, Masumeh Sanaei, Zahra Rezaei
Nanoparticles are tiny materials with nanosized components less than 100 nm in at least one dimension with physicochemical properties, which make them very attractive for medical application. These compounds have been evaluated as potential medicines for several decades. Nanotechnology has provided advances in the various fields of health sciences such as diagnosis, prevention and treatment by application of the agents named nanomedicines, including proteins, polymers, micelles, dendrimers, liposomes, emulsions, nanocapsules and nanoparticles...
October 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30264431/tumor-microenvironmental-factors-have-prognostic-significances-in-advanced-gastric-cancer
#11
Bokyung Ahn, Yang-Seok Chae, Chul Hwan Kim, Youngseok Lee, Jeong Hyeon Lee, Joo Young Kim
Tumor microenvironment is important in the progression and survival of cancer cells. We evaluated the prognostic significance of tumor stroma percentage (TSP), Klintrup-Mäkinen (KM) grade, which reflects the density of inflammatory cells of the tumor, and Glasgow microenvironment score (GMS), a combination of TSP and KM grade, in advanced gastric cancers. A total of 196 pT3 and pT4 gastric cancers were histologically evaluated using TSP, KM grade, and GMS. These were correlated with other clinicopathologic factors including patients' survival...
October 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30191621/predictive-value-of-combined-analysis-of-pro-npy-and-erg-in-localized-prostate-cancer
#12
Gitte Kristensen, Martin Andreas Røder, Kasper Drimer Berg, Johanna Elversang, Diego Iglesias-Gato, José Moreira, Birgitte Grønkaer Toft, Klaus Brasso
This study aimed to investigate if combined analysis of pro-Neuropeptide Y (NPY) and ERG expression in tumor tissue are associated with biochemical failure (BF), castration-based treatment, castration-resistant prostate cancer (CRPC), and prostate cancer (PCa)-specific death for men undergoing radical prostatectomy (RP) for PCa. This study included 315 patients, who underwent RP from 2002 to 2005. Both pro-NPY and ERG expression were analyzed using immunohistochemistry and were scored as low or high and negative or positive, respectively...
October 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30191618/performance-characteristics-of-newer-mic-gradient-strip-tests-compared-with-the-etest-for-antimicrobial-susceptibility-testing-of-neisseria-gonorrhoeae
#13
COMPARATIVE STUDY
Agnez Jönsson, Susanne Jacobsson, Sunniva Foerster, Michelle J Cole, Magnus Unemo
For Neisseria gonorrhoeae susceptibility testing, Etest, comparable to agar dilution, is frequently used. In recent years, newer MIC gradient strip tests have been commercialized. However, these tests have not been appropriately evaluated for gonococci. We evaluated the sensitivity, specificity, accuracy, quality, availability of antimicrobials and cost of the MIC Test Strip (Liofilchem), M.I.C.Evaluator (Oxoid) and Ezy MIC Strip (HiMedia), compared to the reference Etest (bioMérieux), for gonococcal susceptibility testing...
October 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30191615/the-use-of-fluorescent-staining-techniques-for-microscopic-investigation-of-polymorphonuclear-leukocytes-and-bacteria
#14
REVIEW
Maria Alhede, Camilla Stavnsbjerg, Thomas Bjarnsholt
The use of fluorescent stains to visually investigate eukaryotic and/or prokaryotic cells is increasing quickly and manuscripts within all areas of research publish results using fluorescent staining techniques. However, in contrast to literature on traditional histological staining techniques, the literature on fluorescent stains and staining techniques does not offer as good an illustration of cellular morphology. The aim of this guideline is to illustrate different fluorescent stains and staining techniques for imaging immune cells, in particular the polymorphonuclear leukocytes (PMNs), in combination with infecting bacteria as seen in chronic bacterial infections...
October 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30160023/primary-and-secondary-mucosal-melanoma-of-the-small-intestine-a-clinical-pathological-and-genetic-nationwide-survey-of-danish-patients-between-1980-and-2014
#15
Jakob Koefoed Tingsgaard, Amalie Henriksen, Lauge Hjorth Mikkelsen, Nille Behrendt, Linea Cecilie Melchior, Lars Bo Svendsen, Steffen Heegaard
The aim of this study was to describe the epidemiology, symptomatology, pathology, genetics, and treatment of primary and metastatic small intestine melanoma in a national Danish cohort. All Danish patients diagnosed with small intestinal melanoma during the period 1980-2014 were included. For each patient, clinical data along with available pathology report and tissue was registered. Targeted next-generation sequencing (NGS) of known hotspots in 50 oncogenic genes was performed. Twenty patients with small intestinal melanoma were retrieved...
September 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30160022/hypochromatic-large-urothelial-cells-in-urine-cytology-are-indicative-of-high-grade-urothelial-carcinoma
#16
Francesco Pierconti, Maurizio Martini, Patrizia Straccia, Vincenzo Fiorentino, Teresa Musarra, Luigi Maria Larocca, Antonio Lopez-Beltran
In this study, we have examined 67 cytology specimens from patients from 2014 to 2016. The ratio man to women was 4:1 with a median age of 75 years (range: 55-87 years). Thin-Prep processed urinary cytology specimens demonstrated large urothelial cells, with cytologic features of malignancy, thus including hypochromatic nuclei with occasional peripherally accentuated chromatin rim. The cytological diagnosis of High Grade Urothelial Carcinoma (HGUC) was made in 55 patients while 12 specimens were classified as Atypical Urothelial Cells (AUC)...
September 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30160021/stability-of-oestrogen-and-progesterone-receptor-antigenicity-in-formalin-fixed-paraffin-embedded-breast-cancer-tissue-over-time
#17
Anna Ehinger, Pär-Ola Bendahl, Lisa Rydén, Mårten Fernö, Sara Alkner
Use of archived formalin-fixed paraffin-embedded (FFPE) tissue is a standard method for evaluation of proposed prognostic and predictive tumour markers. However, little is known of the preservation of biomarker expression in old FFPE tumour blocks. We investigate the quality of immunohistochemical (IHC) oestrogen (ER) and progesterone receptor (PR) evaluation in FFPE tissue over time (1978-2000) using a large breast cancer tissue microarray (N = 573) with access to receptor analyses in cytosol (CYT) at diagnosis, coexpression of other biomarkers and follow-up data...
September 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30160020/increased-levels-of-serum-mir-148a-3p-are-associated-with-prostate-cancer
#18
Sandra Amalie Dybos, Arnar Flatberg, Jostein Halgunset, Trond Viset, Toril Rolfseng, Solveig Kvam, Haakon Skogseth
Prostate cancer (PCa) is one of the most common types of cancer and the fifth leading cause of death among men worldwide. The tools for diagnosing PCa have limited value, and to improve correct diagnosis there is a need for markers that can contribute to a more precise diagnosis, which would lead to proper treatment of only those patients who need it. Micro RNA (miRNA) plays a key role in the development of cancer and is therefore a potential marker for PCa. Next-generation sequencing was used to discover differences in miRNA expression between serum samples from PCa patients and healthy controls, and the results were validated by quantitative real-time polymerase chain reaction...
September 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30160019/vascular-adhesion-protein-1-as-indicator-of-breast-cancer-tumor-aggressiveness-and-invasiveness
#19
Yen-Chang Clark Lai, Shu-Jyuan Chang, Joanna Kostoro, Aij-Lie Kwan, Chee-Yin Chai
Recent studies suggest that vascular adhesion protein-1 (VAP-1), a 180-KDa homodimeric glycoprotein, may be associated with cancer-related events including tumor cell migration, motility, invasion, or metastasis. Therefore, this study applies VAP-1 immunohistochemical staining to demonstrate the invasiveness component of the breast cancer. The VAP-1 staining results were compared in 148 breast cancer cases to identify possible correlations with clinical status, including age, tumor size, tumor grade, TNM stage, lymphatic invasion, metastasis, recurrence, and survival rate...
September 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/30160018/cd8-and-cd163-infiltrating-cells-and-pd-l1-immunoexpression-in-oral-leukoplakia-and-oral-carcinoma
#20
Olga Stasikowska-Kanicka, Małgorzata Wągrowska-Danilewicz, Marian Danilewicz
Overexpression of inhibitory checkpoint PD1/PD-L1 plays an important role in carcinogenesis and patients prognosis. 70 cases of oral squamous cell carcinoma (OSCC), 23 cases of oral leukoplakia (OLK), and 19 control cases were immunohistochemically stained with anti-PD-L1, -CD8, and -CD163 antibodies. PD-L1 was expressed on dysplastic and subepithelial infiltrating cells of OLK as well as on cancer and tumor-infiltrating cells of OSCC. In OSCC, PD-L1 immunoexpression was significantly increased in comparison to OLK, and control groups...
September 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
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