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Rapid Communications in Mass Spectrometry: RCM

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https://www.readbyqxmd.com/read/29790617/plant-growth-chamber-design-for-subambient-pco-2-and-%C3%AE-13-c-studies
#1
William M Hagopian, Brian A Schubert, Robert A Graper, A Hope Jahren
RATIONALE: Subambient pCO2 has persisted across the major Phanerozoic ice ages, including the entire late Cenozoic (~30 Ma to present). Stable isotope analysis of plant-derived organic matter is used to infer changes in pCO2 and climate in the geologic past, but a growth chamber that can precisely control environmental conditions, including pCO2 and δ13 C value of CO2 (δ13 CCO2 ) at subambient pCO2 , is lacking. METHODS: We designed and built five identical chambers specifically for plant growth under stable subambient pCO2 (~100 to 400 ppm) and δ13 CCO2 conditions...
May 23, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29790616/in-vitro-and-in-vivo-metabolic-profiles-of-fasiglifam-by-using-ultra-high-performance-liquid-chromatography-combined-with-q-exactive-orbitrap-tandem-mass-spectrometry
#2
Jin-Qi Li, Jia-Feng Wang, Jie Li, Shu-Han Zhang, Dan He, Rong-Sheng Tong, Shu-Ya She
RATIONALE: Fasiglifam is an orally available and selective partial agonist of hGPR40 receptor, which was unexpectedly terminated at phase III clinical trials due to its severe hepatotoxicity. To fully understand its mechanism of action, it is necessary to investigate the in vitro and in vivo metabolic profiles of fasiglifam. METHODS: For in vitro metabolism, fasiglifam was incubated with rat or human liver microsomes in the presence of NADPH, GSH and UDPGA for 60 min...
May 23, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29788543/a-new-glutathione-conjugate-of-the-pyrrolizidine-alkaloids-produced-by-human-cytosolic-enzyme-dependent-reactions-in-vitro
#3
Fashe Muluneh, Merja R Häkkinen, Rami El-Dairi, Markku Pasanen, Risto O Juvonen
RATIONALE: The toxic metabolites of pyrrolizidine alkaloids (PAs) are initially formed by cytochrome P450 mediated oxidation reactions and primarily eliminated as glutathione (GSH) conjugates. Although the reaction between the reactive metabolites and GSH can occur spontaneously, the role of the cytosolic enzymes in the process has not been studied. METHODS: The toxic metabolites of selected PAs (retrorsine, monocrotaline, senecionine, lasiocarpine, heliotrine or senkirkine) were generated by incubating them in 100 mM phosphate buffer pH 7...
May 22, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29785738/mass-spectrometry-for-characterization-of-homologous-piperidine-alkaloids-and-their-activity-as-acetylcholinesterase-inhibitors
#4
Thamires R Freitas, Amanda Danuello, Claudio Viegas Júnior, Vanderlan S Bolzani, Marcos Pivatto
RATIONALE: Piperidine alkaloids from Senna spectabilis constitute a rare class of natural products with several biological activities. However, the absence of chromophores makes their structural elucidation by conventional methods a great challenge. In this context, mass spectrometry emerges as a powerful tool for metabolomics studies. METHODS: The piperidine alkaloids (-)-cassine and (-)-spectaline and the semisynthetic derivatives (-)-3-O-acetylcassine and (-)-3-O-acetylspectaline were investigated by electrospray ionization tandem mass spectrometry (ESI-MS/MS) in the positive mode and electron ionization mass spectrometry (EI-MS)...
May 22, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29781092/assimilation-of-nitrogen-and-carbon-isotopes-from-fish-diets-to-otoliths-as-measured-by-nanoscale-secondary-ion-mass-spectrometry
#5
Jen-Chieh Shiao, Kotaro Shirai, Kentaro Tanaka, Naoto Takahata, Yuji Sano, Sung-Yun Hsiao, Der-Chuen Lee, Yung-Che Tseng
RATIONALE: Nitrogen and carbon stable isotope ratios (δ15 N and δ13 C values) of carbonate-bound organic materials in otoliths can provide information to address the biological and ecological functions of fish. Correct interpretation of otolith δ15 N and δ13 C profiles requires knowledge of the metabolic routes of nitrogen and carbon isotopes. However, the isotopic assimilation of δ15 N and δ13 C compositions from diets to otoliths has rarely been investigated. METHODS: This study traced the daily nitrogen and carbon isotopic assimilation between diets and otoliths using nanoscale secondary ion mass spectrometry (NanoSIMS)...
May 21, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29781254/determination-of-carbon-isotope-ratios-for-honey-samples-by-means-of-a-liquid-chromatography-isotope-ratio-mass-spectrometry-system-coupled-with-a-post-column-pump
#6
Hiroto Kawashima, Momoka Suto, Nana Suto
RATIONALE: Liquid chromatography/isotope ratio mass spectrometry (LC/IRMS) has been used to authenticate and trace products such as honey, wine, and lemon juice, and compounds such as caffeine and pesticides. However, LC/IRMS has several disadvantages, including the high cost of the CO2 membrane and blocking by solidified sodium persulfate. Here, we developed an improved system for determining carbon isotope ratios by LC/IRMS. METHODS: The main improvement was the use of a post-column pump...
May 20, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29781236/detection-of-acetyltransferase-modification-of-kanamycin-an-aminoglycoside-antibiotic-in-bacteria-using-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#7
Johnny J Perez, Chin-Yi Chen
RATIONALE: The occurrence of antibiotic resistant (AR) bacteria is a worldwide issue that has the potential, if not addressed, to eliminate classes of antibiotics that have extended life expectancy in the last century. An approach to confront this threat is the development of technologies that greatly accelerate the detection of AR to minimize unnecessary treatment involving antibiotics. Development of an analytical method for rapid detection of aminoglycoside resistance using liquid chromatography mass spectrometry (LC-MS) has not been reported in literature and is described here...
May 20, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29781217/uhplc-q-tof-ms-based-screening-and-identification-of-main-flavonoids-and-their-metabolites-in-rats-after-oral-administration-of-cirsium-japonicum-dc-extract
#8
Xia Zhang, Man Liao, Xiaoye Cheng, Caijuan Liang, Xinpeng Diao, Lantong Zhang
RATIONALE: Cirsium japonicum DC., a traditional Chinese medicine, has been shown to have antihemorrhagic and antitumour effects. Pharmacological studies have demonstrated that this curative effect may be related to flavonoids. The present work aims to screen and identify the main flavonoids and their corresponding metabolites in rats after oral administration of Cirsium japonicum DC. extract. METHODS: A rapid and simple ultra-high-performance liquid chromatography coupled with triple quadrupole and time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS) method was developed for the identification of the primary absorbing components and metabolites of the principal flavonoids...
May 20, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29777557/are-stable-isotope-ratios-and-oscillations-consistent-in-all-baleen-plates-along-the-filtering-apparatus-validation-of-an-increasingly-used-methodology
#9
Raquel García-Vernet, Pol Sant, Gísli Víkingsson, Asunción Borrell, Alex Aguilar
RATIONALE: Baleen plates are anatomical structures composed of inert tissue that hang from the upper jaw in mysticetes. Baleen plates may differ in size and in coloration between different segments of the filtering row or between sides of the mouth. Concern has been raised that variation in baleen plate characteristics may reflect dissimilar structural composition and growth rates liable of affecting the stable isotope ratios and their oscillation patterns. METHODS: We measured stable carbon (δ13 C values) and nitrogen (δ15 N values) isotope ratios at intervals of one centimeter along the longitudinal axis of six baleen plates collected from different positions along the mouth of a fin whale...
May 18, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29777551/a-new-method-for-quantitative-determination-of-renalase-based-on-mass-spectrometry-determination-of-a-proteotypic-peptide-labeled-with-stable-isotopes
#10
A T Kopylov, V I Fedchenko, O A Buneeva, N V Pyatakova, V G Zgoda, A E Medvedev
RATIONALE: Renalase is a recently discovered kidney secretory protein, which is considered as an important component involved in blood pressure regulation. Although altered levels of renalase have been detected in plasma and urine of patients with various kidney diseases, there is certain inconsistency of changes in the renalase levels reported by different laboratories. The latter is obviously associated with the use of ELISA as the only available approach for quantitative analysis of renalase...
May 18, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29777550/evidence-for-dietary-time-series-in-layers-of-cetacean-skin-using-stable-carbon-and-nitrogen-isotope-ratios
#11
Lauren A Wild, Ellen M Chenoweth, Franz J Mueter, Janice M Straley
RATIONALE: Stable isotope analysis integrates diet information over a time period specific to the type of tissue sampled. For metabolically active skin of free-ranging cetaceans, cells are generated at the basal layer of the skin and migrate outward until they eventually slough off, suggesting potential for a dietary time series. METHODS: Skin samples from cetaceans were analyzed using continuous-flow elemental analyzer isotope ratio mass spectrometery (EA-IRMS)...
May 18, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29757475/rapid-analysis-of-fentanyls-and-other-novel-psychoactive-substances-nps-in-substance-use-disorder-patient-urine-using-paper-spray-mass-spectrometry
#12
Joseph H Kennedy, Jan Palaty, Chris G Gill, Justin M Wiseman
RATIONALE: Drug overdose deaths due to fentanyls and other novel psychoactive substances (NPS) are on the rise. The higher potencies of fentanyl analogs compared with morphine require new technologies to identify and quantitate NPS. METHODS: Paper spray tandem mass spectrometry and high-resolution mass spectrometry were used to identify and measure fentanyl analogs as well as common drugs of abuse in urine samples from substance use disorder clinics. Ten-microliter urine samples were deposited directly on paper spray cartridges previously loaded with internal standards, dried, and analyzed with no other sample treatment...
May 14, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29756663/coupling-trapped-ion-mobility-spectrometry-to-mass-spectrometry-tims-tof-ms-vs-tims-ft-icr-ms
#13
Lilian V Tose, Paolo Benigni, Dennys Leyva, Abigail Sundberg, César E Ramírez, Mark E Ridgeway, Melvin A Park, Wanderson Romão, Rudolf Jaffé, Francisco Fernandez-Lima
RATIONALE: There is a need for fast, post-ionization separation during the analysis of complex mixtures. In this study, we evaluate the use of a high-resolution mobility analyzer with high resolution and ultra-high-resolution mass spectrometry for unsupervised molecular feature detection. Goals include the study of the reproducibility of TIMS across platforms, applicability range and potential challenges during routine analysis. METHODS: A TIMS analyzer was coupled to TOF-MS and to an FT-ICR MS for the analysis of single charge species in the m/z 150-800 range of a complex mixture (Suwannee River Fulvic Acid Standard)...
May 14, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29756659/fragmentation-pathways-arising-from-protonation-at-different-sites-in-aminoalkyl-substituted-3-hydroxy-1-2-5-oxadiazoles-3-hydroxyfurazans
#14
J Stuart Grossert, Donatella Boschi, Marco L Lolli, Robert L White
RATIONALE: The gas-phase fragmentation chemistry of multifunctional cations is highly influenced by the site of protonation. Possible relationships between protonation site and fragmentation processes were studied using 4-aminoalkyl-3-hydroxyfurazans. For these heterocyclic amines, the starting points for competing fragmentation pathways varied with protonation at multiple sites in two tautomers. METHODS: Mass spectra were acquired using electrospray ionization (ESI, positive mode) coupled to triple quadrupole and ion trap mass spectrometers; precursor-product ion relationships were studied by collision induced dissociation (CID)...
May 14, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29740899/evaluation-of-coal-related-model-compounds-using-a-tandem-mass-spectrometry
#15
Guo-Sheng Li, Xueming Dong, Xing Fan, Chun-Yan You, Ge Wu, Yun-Peng Zhao, Yao Lu, Xian-Yong Wei, Feng-Yun Ma
RATIONALE: Gas chromotography/mass spectrometry (GC/MS) is a routine and basic instrumental method for the analysis of complex coal conversion products in chemical industry. To further enhance practical potentials of GC/MS in chemical industry, a tandem MS method for the selection of ion pair applied in monitoring coal conversions was established by using GC/quadrupole time-of-flight MS (GC/Q-TOF MS). The corresponding fragmentation pathways were explored and suitable ion pairs were screened...
May 8, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29740888/artefactual-formation-of-pyruvate-from-in-source-conversion-of-lactate
#16
Sophie Trefely, Clementina Mesaros, Pening Xu, Mary T Doan, Helen Jiang, Oya Altinok, Zulfiya Orynbayeva, Nathaniel W Snyder
RATIONALE: Lactate and pyruvate are high abundance products of glucose metabolism. Analysis of both molecules as part of metabolomics studies in cellular metabolism and physiology have been aided by advances in liquid chromatography-mass spectrometry (LC-MS). METHODS: We used ion pairing-chromatography and negative ion mode ESI on an QExactive HF to perform stable isotope assisted metabolomics profiling of lactate and pyruvate metabolism. RESULTS: Using an LC-MS method for polar metabolite analysis we discovered an artefactual formation of pyruvate from in-source fragmentation of lactate...
May 8, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29740881/electrospray-ionization-study-of-tricarbonyl-fac-re-co-3-po-x-type-complexes-influence-of-ancillary-co-ligands-in-the-release-of-carbon-monoxide
#17
Francesco Tisato, Marina Porchia, Antoni Shegani, Theodosia Maina, Minas S Papadopoulos, Roberta Seraglia, Pietro Traldi
RATIONALE: fac-[Re(CO)3 (PO)(X)]-type complexes (PO = chelated bidentate tertiary phosphine(1-), X = various neutral, mono-dentate ligands) represent a class of compounds that meets the synthetic criteria for the preparation of potential carbon monoxide (CO) release molecules (CORMs) for medicinal application. The aim of our investigation was to achieve qualitative information whether the nature of the ancillary X ligand might influence the release of CO. METHODS: The release of CO has been investigated by means of product ion spectrometry of electrospray ionization-generated [M + H]+ species, produced by multiple collisional experiments, using an ion trap mass spectrometer...
May 8, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29733470/-tmt-n-clusters-as-dilute-debris-free-tin-source-for-generation-of-multiply-charged-tin-ions-of-relevance-in-extreme-ultraviolet-euv-lithography-under-intense-laser-irradiation
#18
Pramod Sharma, Soumitra Das, Rajesh K Vatsa
RATIONALE: Multiply charged tin ions ([Sn]8+ to [Sn]13+ ) are considered as ideal-emitters at extreme ultraviolet (EUV) wavelength ~ 13.5 nm, pertinent to advanced micro-electronic device fabrication. Solid tin targets have been widely explored for the generation of these ions, but debris generation has restricted their utilization. Tin-containing molecular clusters have, however, the potential to act as dilute and debris-free sources for the generation of tin ions, as investigated in the present study...
May 7, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29729057/determination-of-tebuconazole-and-penconazole-fungicides-in-rat-and-human-hair-by-liquid-chromatography-tandem-mass-spectrometry
#19
Elisa Polledri, Rosa Mercadante, Silvia Fustinoni
RATIONALE: Tebuconazole (TEB) and penconazole (PEN) are widely applied fungicides and environmental contaminants; their toxicological properties include possible effects to the unborn child, therefore the evaluation of human exposure is relevant to risk assessment. Hair is a non-invasive specimen that incorporates pollutants allowing an extended exposure window to be surveyed. Aim of this work was to develop and validate an assay for the determination of TEB and PEN in human hair. METHODS: Under optimised conditions, analytes were extracted soaking hair in acetonitrile, in the presence of deuterated analogues, under heating and agitation...
May 4, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29729051/preliminary-assessment-of-stable-nitrogen-and-oxygen-isotopic-composition-of-usgs51-and-usgs52-nitrous-oxide-reference-gases-and-perspectives-on-calibration-needs
#20
Nathaniel E Ostrom, Hasand Gandhi, Tyler B Coplen, Sakae Toyoda, J K Böhlke, Willi A Brand, Karen L Casciotti, Jens Dyckmans, Anette Giesemann, Joachim Mohn, Reinhard Well, Longfei Yu, Naohiro Yoshida
RATIONALE: Despite a long history and growing interest in isotopic analyses of N2 O, there is a lack of isotopically characterized N2 O isotopic reference materials (standards) to enable normalization and reporting of isotope-delta values. Here we report the isotopic characterization of two pure N2 O gas reference materials, USGS51 and USGS52, which are now available for laboratory calibration (https://isotopes.usgs.gov/lab/referencematerials.html). METHODS: A total of 400 sealed borosilicate glass tubes of each N2 O reference gas were prepared from a single gas filling of a high vacuum line...
May 4, 2018: Rapid Communications in Mass Spectrometry: RCM
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