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Rapid Communications in Mass Spectrometry: RCM

Xin Ma, Jing Liu, Zhengxiang Zhang, Tao Bo, Yu Bai, Huwei Liu
RATIONALE: Quadrupole based tandem mass spectrometry (MS/MS) plays critical role in "omics" studies. However, when a particular m/z precursor is selected by the quadrupole, ions other than the precursor are not transmitted through, the sensitivity and dynamic range thus diminish. Therefore, separation techniques such as ion mobility (IM) is coupled with MS/MS to improve it. METHODS: In this workflow, every IM-mass spectrometry (MS) scan was followed by one high collision energy (CE) scan...
October 19, 2016: Rapid Communications in Mass Spectrometry: RCM
Mengzhe Guo, Dengyang Yin, Jie Han, Cheng Guo, Xiao Li, Liyan Zhang, Yan Du, Haibo Wang, Daoquan Tang
RATIONALE: Mass spectrometry has been developed as one of the common tools for the analysis of the organometallic systems in the gas phase over decades. The study of the fragmentation of organics-metal complexes has attracted much attention since the interesting dissociation pathways exhibited by these compounds are usually different from the protonated analogues. METHODS: In this work, iohexol complexed with different dications such as Mg(2+) , Cu(2+) , and Zn(2+) have been investigated by ESI tandem mass spectrometry...
October 17, 2016: Rapid Communications in Mass Spectrometry: RCM
Kenion H Blakeman, Craig A Cavanaugh, William M Gilliland, J Michael Ramsey
RATIONALE: There are many chemical measurement scenarios that would benefit from hand portable mass spectrometry tools including forensics, environmental monitoring, and safety and security. High pressure mass spectrometry (HPMS) facilitates miniaturization by significantly reducing vacuum system requirements. Previous work demonstrated HPMS using helium buffer gas, but HPMS conducted using ambient air would further reduce the size and weight of a portable instrument while also reducing logistical demands by eliminating the need for a helium supply...
October 17, 2016: Rapid Communications in Mass Spectrometry: RCM
Viktor A Vorozhtcov, Valentina L Stolyarova, Sergey I Lopatin, Sergey M Shugurov, Andrey L Shilov, Vladimir F Sapega
RATIONALE: The Bi2 O3 -P2 O5 -SiO2 system possesses a number of valuable properties that may be of use for various practical applications, both for obtaining new materials e.g. optical fibers and for replacing systems based on toxic lead silicate. Information on vaporization processes and thermodynamic properties obtained in the present study will be useful for the development of synthesis methods and approaches for modeling the thermodynamic properties of materials based on this system...
October 14, 2016: Rapid Communications in Mass Spectrometry: RCM
Ravali Alagandula, Xiang Zhou, Baochuan Guo
RATIONALE: LC-MS/MS is the gold standard of urine drug testing. However, current LC-based methods are time consuming, limiting the throughput of MS-based testing and increasing the cost. This is particularly problematic for quantification of drugs such as phenobarbital, which is often analyzed in a separate run because they must be negatively ionized. METHOD: This study examined the feasibility of using a dilute and shoot-flow injection method without LC separation to quantify drugs with phenobarbital as a model system...
October 14, 2016: Rapid Communications in Mass Spectrometry: RCM
Xiu-Ping Chen, Ruo-Jing Fan, Fang Zhang, Zhong-Quan Li, Bin Xu, Yin-Long Guo
RATIONALE: In order to improve analysis of analytes in trace amounts in a complex matrix, we developed a novel post-processing method, named Chromatographic Peak Reconstruction (CPR), to process the recorded data from gas chromatography time-of-flight mass spectrometry (GC-TOF MS). METHODS: For a trace ion, the relative deviation (δ) between the adjacent scanned mass-to-charge ratios (m/z) was found inversely proportional to its MS peak intensity. Based on this relationship, the thresholds of δ value within the specified intensity segments were estimated by the CPR and used to screen out the suspicious scan-points in the extracted ion chromatographic (EIC) peak...
October 10, 2016: Rapid Communications in Mass Spectrometry: RCM
Tohru Yamagaki, Michika Takeuchi, Takehiro Watanabe, Kohtaro Sugahara, Takae Takeuchi
RATIONALE: Proton and radical are transferred between matrices and matrix and analyte in matrix-assisted laser desorption/ionization (MALDI) and these transfers drive ionization of analytes. The odd-electron anion [M - 2H] ̇(-) was generated in dihydroxybenzoic acid (DHBs) and the ion abundance of the 2,5-DHB was much highest among six DHBs. We were interested in the mechanism of the ion generation of the odd-electron anion. METHODS: The observed [M - 2H] ̇(-) and [M - 3H](-) ions, which were generated with the hydrogen radical removing from the phenolic hydroxyl groups (OH) in DHB isomers, were analyzed using MALDI MS...
October 7, 2016: Rapid Communications in Mass Spectrometry: RCM
Takumi Tsutaya, Yui Fujimori, Misato Hayashi, Minoru Yoneda, Takako Miyabe-Nishiwaki
RATIONALE: Estimation of the stable isotopic offsets between tissue and diet is important for dietary reconstructions. Although stable isotopic studies of chimpanzees (Pan troglodytes) are increasing, the isotopic offsets in chimpanzees have never been studied. In this study, the carbon and nitrogen stable isotopic offset values in hair and feces were measured for 13 captive chimpanzees for the first time. METHODS: All consumed food items and quantities were recorded for each individual for one week...
October 7, 2016: Rapid Communications in Mass Spectrometry: RCM
H K Patterson, R H Carmichael
RATIONALE: Extraction of lipids from tissues prior to carbon stable isotope analysis (SIA) has become a common practice, despite a lack of species-specific data to indicate when lipid extraction is needed. Marine invertebrates, including bivalves, are known to store carbon as glycogen and less in the form of lipids than other species, potentially reducing the need for lipid extraction even when C:N values are above 3.5, a value that previous studies suggest indicates a need for lipid extraction of animal tissues...
October 5, 2016: Rapid Communications in Mass Spectrometry: RCM
Claudio Medana, Valentina Santoro, Federica Dal Bello, Cecilia Sala, Marco Pazzi, Marco Sarro, Paola Calza
RATIONALE: Nicotine and cotinine are respectively an alkaloid produced mainly by the Solanaceae plant family, especially tobacco, and its most important human metabolite. These compounds are frequently found as contaminants in wastewater or landfill samples and they could be used to evaluate pollution by tobacco use. The aim of this study is to improve the knowledge about possible transformation pathways of nicotine and cotinine. This would help the identification of degradants by using HPLC coupled with a high resolving power mass analyzer (LTQ-orbitrap)...
October 5, 2016: Rapid Communications in Mass Spectrometry: RCM
Seyed Esmaeil Hosseini, Hamid Saeidian, Ali Amozadeh, Mohammad Taghi Naseri, Mehran Babri
RATIONALE: For unambiguous identification of Chemical Weapons Convention (CWC)-related chemicals in environmental samples, the availability of mass spectra, interpretation skills and rapid microsynthesis of suspected chemicals are essential requirements. For the first time, the electron-ionization single quadrupole and electrospray ionization tandem mass spectra of a series of O-alkyl N-[bis(dimethylamino)methylidene]-P-methylphosphonamidates (Scheme 1, cpd 4) were studied for CWC verification purposes...
October 5, 2016: Rapid Communications in Mass Spectrometry: RCM
Kermit King Murray
No abstract text is available yet for this article.
October 5, 2016: Rapid Communications in Mass Spectrometry: RCM
Wennian Han, Lianjun Feng, Hongwei Li, Wei Liu
RATIONALE: Elemental analyzer-isotope ratio mass spectrometry (EA-IRMS) has been widely used for nitrogen isotope ratio determination in various organic and inorganic samples. However, the extent of the redox reaction in the EA reaction tube can greatly affect the accuracy and precision of measurements, especially in the case of complex geological samples. It is therefore necessary to determine the appropriate reaction conditions to reach a high recovery of nitrogen by complete combustion or thermal decomposition and quantitative reduction...
October 4, 2016: Rapid Communications in Mass Spectrometry: RCM
Li-Hua Lo, Jentaie Shiea, Tiao-Lai Huang
PURPOSE: The aim of this study is to use a technique that combines acid hydrolysis and matrix-assisted laser desorption/ionization/time-of-flight mass spectrometry (MALDI-TOF MS) in order to detect the serum biomarkers of patients diagnosed with schizophrenia both before and after four-week antipsychotic treatment with risperidone. METHODS: During this study's two-year period, inpatients were diagnosed with schizophrenia using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID)...
October 4, 2016: Rapid Communications in Mass Spectrometry: RCM
Andrew C Smith, Christopher P Kendrick, Vicky L Moss-Hayes, Christopher H Vane, Melanie J Leng
RATIONALE: The carbon isotope (δ(13) C value) composition of fossil plant material is routinely used as a proxy of past climate and environment change. However, palaeoclimate interpretation requires assumptions about the stability of δ(13) C values in plant material during its decomposition and incorporation into sediments. Previous work on modern angiosperm species show δ(13) C changes of several per mille during simulated decomposition experiments. However, no such tests have been undertaken on non-flowering plants, which are found extensively within geological record...
October 4, 2016: Rapid Communications in Mass Spectrometry: RCM
J K Böhlke, Stanley J Mroczkowski, Neil C Sturchio, Linnea J Heraty, Kent W Richman, Donald B Sullivan, Kris N Griffith, Baohua Gu, Paul B Hatzinger
RATIONALE: Perchlorate (ClO4(-) ) is a common trace constituent of water, soils, and plants; it has both natural and synthetic sources and is subject to biodegradation. The stable isotope ratios of Cl and O provide three independent quantities for ClO4(-) source attribution and natural attenuation studies: δ(37) Cl, δ(18) O, and δ(17) O (or Δ(17) O or (17) Δ) values. Documented reference materials, calibration schemes, methods, and interferences will improve the reliability of such studies...
October 3, 2016: Rapid Communications in Mass Spectrometry: RCM
Karin A Ebert, Christine Laskov, Martin Elsner, Stefan B Haderlein
RATIONALE: The recent development of compound-specific online chlorine isotope analysis ((37) Cl-CSIA) methods has fostered dual chlorine-carbon isotope studies to gain better insights into sources and environmental transformation reactions of chlorinated ethenes (CEs). 1-point and 2-point calibration schemes are currently used to convert raw data to the international δ(37) ClSMOC scale, but a critical evaluation of best practices to arrive at reliable δ(37) ClSMOC signatures and enrichment factors was missing and is presented here...
September 30, 2016: Rapid Communications in Mass Spectrometry: RCM
Rachel Fickes, Dennis R Voelker, Karin Zemski Berry, Robert C Murphy
RATIONALE: Structural analogs of the bioactive lipid, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, were synthesized with a xylitol polar headgroup and both diacyl and diether radyl groups. Mass spectral characterization of xylitol phospholipids (PX) was carried out using collisional activation and high resolution mass measurements of positive molecular ion species and compared with the phosphatidylglycerol (PG) analogs. METHODS: Xylitol phospholipids were synthesized using a transphosphatidylation reaction catalyzed by phospholipase D and purified by HPLC...
September 30, 2016: Rapid Communications in Mass Spectrometry: RCM
Melvin E Klegerman, Melanie R Moody, Jermaine R Hurling, Tao Peng, Shao-Ling Huang, David D McPherson
RATIONALE: We have produced a liposomal formulation of xenon (Xe-ELIP) as a neuroprotectant for inhibition of brain damage in stroke patients. This mandates development of a reliable assay to measure the amount of dissolved xenon released from Xe-ELIP in water and blood samples. METHODS: Gas chromatography-Mass Spectrometry (GC-MS) was used to quantify xenon gas released into the headspace of vials containing Xe-ELIP samples in water or blood. In order to determine blood concentration of xenon in vivo after Xe-ELIP administration, 6 mg Xe-ELIP lipid was infused intravenously into rats...
September 30, 2016: Rapid Communications in Mass Spectrometry: RCM
Michael C Doran, Kelly L LeBlanc
RATIONALE: Software accompanying High Resolution Mass Spectrometers (HRMS), particularly that used for the analysis of organometallic compounds, has lagged the technology of the instruments themselves. We have developed a computer program that partially fills this gap. METHODS: Given the user's expectation for the number of atoms of a target element likely to be in an ion, the program calculates isotopologue mass differences for combinations of that element's isotopes and their expected intensity ratios relative to the most abundant isotopologue...
September 30, 2016: Rapid Communications in Mass Spectrometry: RCM
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