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Rapid Communications in Mass Spectrometry: RCM

Ilaria Di Marco Pisciottano, Grazia Guadagnuolo, Vittorio Soprano, Michele De Crescenzo, Pasquale Gallo
RATIONALE: Phytocannabinoids are natural compounds produced by Cannabis spp. Some of them show psychotropic effects on humans and are therefore are used as drugs of abuse. These compounds are present in food and beverages containing ingredients from hemp, and thus can reach consumers. The Italian Ministry of Health planned to evaluate the intake of cannabinoids from food containing hemp ingredients. Thus, we were asked to develop and validate a multi-residue test method to determine nine phytocannabinoids in beverages and food...
July 21, 2018: Rapid Communications in Mass Spectrometry: RCM
Johnny J Perez, Chin-Yi Chen
RATIONALE: Worldwide efforts are underway to determine the extent of antimicrobial resistance (AMR). In 2015, the world health organization (WHO) founded the global antimicrobial surveillance system (GLASS) focusing on surveillance and dissemination of data. In addition, WHO advocates method development focused on rapid determination and close to real time monitoring of antibiotic usage and its effectiveness. Rapid determination of aminoglycoside modification by O-phosphorylation, the most prevalent mechanism of clinical resistance, was performed using direct flow- and liquid chromatography mass spectrometry (LC-MS)...
July 21, 2018: Rapid Communications in Mass Spectrometry: RCM
Vincent L'Hérault, Nicolas Lecomte, Marie-Hélène Truchon, Dominique Berteaux
RATIONALE: Stable isotope analysis is widely used to reconstruct diet, delineate trophic interactions, and determine energy pathways. Such ecological inferences are based on the idea that animals are, isotopically, what they eat but with a predictable difference between the isotopic ratio of a consumer and that of its diet, coined as the discrimination factor. Providing correct estimates of diet-consumer isotopic discrimination in controlled conditions is key for a robust application of the stable isotopes technique in the wild...
July 21, 2018: Rapid Communications in Mass Spectrometry: RCM
Nana Suto, Hiroto Kawashima
RATIONALE: Water-soluble organic carbon (WSOC) is formed by oxidation of organic compounds in particulate matter (PM) and accounts for 25-80% of the organic carbon in PM. Stable carbon isotope ratio (δ13 C) analysis is widely used to identify the sources of PM, but determining the δ13 C values of WSOC is complicated and requires a time-consuming pretreatment process. METHODS: We have developed an online wet oxidation/isotope ratio mass spectrometry method with a reduced pretreatment time...
July 21, 2018: Rapid Communications in Mass Spectrometry: RCM
Rabah Gahoual, Emmanuelle Leize-Wagner, Pascal Houzé, Yannis-Nicolas François
Capillary electrophoresis and mass spectrometry (CE-MS) hyphenation remains a minor technique compared to liquid chromatography - mass spectrometry (LC-MS), which represents nowadays the standard instrumentation, regardless of its introduction thirty years ago. However, from a theoretical point of view CE coupling should be quite favorable especially with electrospray ionization mass spectrometry (ESI-MS). At time, the sensitivity provided by CE-MS was often limited, due to hyphenation requirements, which at some point appeared to disqualify CE-MS from benefiting of the performance gain driving the evolution of MS instruments...
July 18, 2018: Rapid Communications in Mass Spectrometry: RCM
Kathrin Engel, Hans Griesinger, Michael Schulz, Jürgen Schiller
RATIONALE: Normal phase thin-layer chromatography (NP-TLC) is an established method for the separation of all major phospholipid classes according to the different polarities of the head groups. In contrast, reversed phase (RP) TLC is much less frequently used for this purpose. This study aimed to compare the NP and the RP approach regarding their separation potential of phospholipid oxidation products. METHODS: Commercially available POPC (PC 16:0/18:1) and PLPC (PC 16:0/18:2) were oxidized by NaMnO4 ...
July 18, 2018: Rapid Communications in Mass Spectrometry: RCM
Filip Cuyckens
Drug Metabolism and Pharmacokinetics (DMPK) is a core scientific discipline within drug discovery and development as well as post-marketing. It helps to design and select the most promising drug candidate and obtain advanced insights on the processes that control absorption, distribution, metabolism and excretion (ADME) of the final drug candidate. Mass spectrometry is one of the key technologies applied in DMPK. Therefore, the continuous advances made in the field of mass spectrometry also directly impact the way in which we investigate the ADME properties of a compound, providing us with new tools to gather more information or improve our efficiency...
July 17, 2018: Rapid Communications in Mass Spectrometry: RCM
Congcong Zhang, Jian Hu, Fengmei Sun, Man Jia, Gang Chen, Cuiling Wu, Lufei Zheng
RATIONAL: An analysis method of gentamicin in animal tissues was developed and validated. The alkaline mobile phase with an HPH C8 column was selected so that all the four gentamicin components were retained and eluted without using fluorinated ion-pair reagents. METHODS: The method is sufficiently sensitive and highly selective, using a strong cation-exchange solid-phase cartridge (PCX) to clean up the samples. The different types of solid-phase extraction column and membrane were considered to obtain a high recovery...
July 17, 2018: Rapid Communications in Mass Spectrometry: RCM
Mahendra P Verma, Robert van Geldern, Johannes A C Barth, Gael Monvoisin, Karyne Rogers, Fausto Grassa, Daniel Carrizo, Antonio Delgado Huertas, Thomas Kretzschmar, Ruth Esther Villanueva Estrada, José Marcus Godoy, Roslanzairi Mostapa, Hugo Alberto Durán Cortés
RATIONALE: Knowledge of the accuracy and precision for oxygen (δ18 O values) and hydrogen (δ2 H values) stable isotope analyses of geothermal fluid samples is important to understand geothermal reservoir processes, such as partial boiling-condensation and encroachment of cold and reinjected waters. The challenging aspects of the analytical techniques for this specific matrix include memory effects and higher scatter of delta values with increasing total dissolved solids (TDS) concentrations, deterioration of Pt-catalysts by dissolved/gaseous H2 S for hydrogen isotope equilibration measurements and isotope salt effects that offsets isotope ratios determined by gas equilibration techniques METHODS: An inter-laboratory comparison exercise for the determination of the δ18 O and δ2 H values of nine geothermal fluid samples was conducted among eleven laboratories from eight countries (CeMIEGeo2017)...
July 14, 2018: Rapid Communications in Mass Spectrometry: RCM
Li Zong, Zifeng Pi, Shu Liu, Junpeng Xing, Zhiqiang Liu, Fengrui Song
RATIONALE: Multidrug resistance (MDR) occurs frequently and has a major challenge in tumor treatment. Lipid composition in cell membrane and the redox balance are closely associated with the development of MDR. The liquid extraction surface analysis in combination with mass spectrometry (LESA-MS) has the characteristics of minimal sample preparation, rapid analysis, high sensitivity and high throughput, and has obtained wide applications. METHODS: The LESA-MS was employed to in situ determine the lipids and other specific metabolites of intact MCF-7/ADR cells (adriamycin-resistant breast cancer cells) and its parental MCF-7/S cells grew on the glass slide...
July 12, 2018: Rapid Communications in Mass Spectrometry: RCM
Thomas E Helser, Craig R Kastelle, Jennifer L McKay, Ian J Orland, Reinhard Kozdon, John W Valley
RATIONALE: Stable oxygen isotope ratios (δ18 O values) measured in fish otoliths can provide valuable detailed information on fish life history, fish age determination, and ocean thermography. Traditionally, otoliths are sampled by micromilling followed by isotope ratio mass spectrometry (IRMS), but direct analysis by secondary ion mass spectrometry (SIMS) is becoming more common. However, these two methods have not been compared to determine which, if either, is better for fish age validation studies...
July 11, 2018: Rapid Communications in Mass Spectrometry: RCM
Xiaojun Li, Kushani Attanayake, Steve Valentine, Peng Li
RATIONALE: The development of miniaturized and field portable mass spectrometers could not succeed without a simple, compact, and robust ionization source. Here we present a voltage-free ionization method, Vibrating Sharp-edge Spray Ionization (VSSI), which can generate a spray of liquid samples using only one standard microscope glass slide to which a piezoelectric transducer is attached. Compared to existing ambient ionization methods, VSSI eliminates the need of a high electric field (~5000 V·cm-1 ) for spray generation, while sharing a similar level of simplicity and flexibility with the simplest direct ionization techniques currently available such as paper spray ionization (PSI) and other solid substrate-based electrospray ionization methods...
July 11, 2018: Rapid Communications in Mass Spectrometry: RCM
Sébastien Hupin, Hélène Lavanant, Séverine Renaudineau, Anna Proust, Guillaume Izzet, Michael Groessl, Carlos Afonso
RATIONALE: Polyoxometalates (POM) are remarkable oxo-clusters forming compact highly charged anions. We measured their collision cross sections (CCS) in N2 with drift tube ion mobility spectrometry (DTIMS). These values were then used to calibrate a traveling wave ion mobility spectrometry (TWIMS) device and the accuracy of the calibration was tested. METHODS: Six POM standards were analyzed by DTIM-MS (Tofwerk, Thun, Switzerland) at different voltages to determine absolute DT CCS(N2 )...
July 10, 2018: Rapid Communications in Mass Spectrometry: RCM
Sébastien Schramm, Nora Zannoni, Valérie Gros, Ralf Tillmann, Astrid Kiendler-Scharr, Roland Sarda-Estève, Maxime Bridoux
RATIONALE: Secondary organic aerosols (SOAs) represent a significant portion of total atmospheric aerosols. They are generated by the oxidation of volatile organic compounds (VOCs), and particularly biogenic VOCs (BVOCs). The analysis of such samples is usually performed by targeted methods that often require time-consuming preparation steps that can induce loss of compounds and/or sample contaminations. METHODS: Recently, untargeted methods using high-resolution mass spectrometry (HRMS) have been successfully employed for a broad characterization of chemicals in SOAs...
July 4, 2018: Rapid Communications in Mass Spectrometry: RCM
Alka Choudhary, Lynn M Naughton, Alan D W Dobson, Dilip K Rai
RATIONALE: In recent years, metabolites produced by Pseudovibrio species have gained scientific attention due to their potent antimicrobial activity. Recently we also have assessed antibacterial activities of Pseudovibrio sp. W64 isolates against Staphylococcus aureus, where only the dominant tropodithietic acid (TDA) was identified. However characterisation of other metabolites is necessary as these metabolites may also serve as potent antimicrobial agents. METHODS: LC-MS/MS, aided by accurate mass measurements, was employed to screen and characterise a range of metabolites produced by Pseudovibrio sp...
July 3, 2018: Rapid Communications in Mass Spectrometry: RCM
Dongwon Shin, Dabin Lee, Yeoseon Kim, Inyoung Kim, Jihyun Paek, Jeongkwon Kim
No abstract text is available yet for this article.
July 3, 2018: Rapid Communications in Mass Spectrometry: RCM
M J Apsokardu, D E Kerecman, M V Johnston
RATIONALE: In droplet assisted ionization (DAI), intact molecular ions are generated from molecules in aerosol droplets by passing the droplets through a temperature controlled capillary inlet. Ion formation is explored through the effects of analyte mass flow, droplet solvent composition, and capillary temperature on ion signal intensity. METHODS: A Waters SYNAPT G2-S is adapted for DAI by reconfiguring the inlet with a temperature controlled capillary. Droplets are generated by atomization of a solution containing analyte and then sampled through the inlet...
July 3, 2018: Rapid Communications in Mass Spectrometry: RCM
Shiona Hood, Tony Peter, Stephen J Blanksby, David L Marshall
RATIONALE: Analysis of water-based personal lubricants can provide pivotal information to law enforcement regarding sexual assault allegations, particularly in the absence of biological evidence. Traditional methodology for the extraction and analysis of water-based lubricants is cumbersome, time-consuming, and is often not sufficiently selective or sensitive to fully characterise the wide range of chemical components present within complex formulations. METHODS: Liquid extraction surface analysis (LESA) was deployed in combination with high-resolution mass spectrometry (HRMS) and tandem mass spectrometry (MS/MS) to screen a range of water-based lubricants directly from contaminated cotton fabric...
July 2, 2018: Rapid Communications in Mass Spectrometry: RCM
Edoardo Longo, Fabrizio Rossetti, Vakare Merkyte, Agnieszka Obiedzińska, Emanuele Boselli
RATIONALE: Cyclic B-type (referred also as crown) proanthocyanidins were recently identified in wines. An HPLC-HRMS/MS method was applied to study the binding of cyclic and non-cyclic PAC to potassium and calcium ions, which affect the chemico-physical stability of wines. Different binding affinities suggest that cyclic and non-cyclic analogues, despite the equal number of monomer units, influence the colloidal stability of wine and are related to the grape variety or winemaking conditions...
July 2, 2018: Rapid Communications in Mass Spectrometry: RCM
Rodríguez Patiño Gabriela, Castillo Rodríguez Miriam Aide, Ramírez Bribiesca Jacinto Efren, Ramírez Noguera Patricia, Gonsebatt Bonaparte María Eugenia, López Arellano Raquel
RATIONALE: Isoprostane 8-iso-PGF2α is a biomarker of lipid peroxidation in cell membranes. The method developed to measure plasma total levels (esterified+ free) of 8-iso-PGF2α must be reproducible and be able to reduce the use of solvents in solid phase extraction. It should be useful to evaluate oxidative stress due to the excess of free radicals that are generated by some disorder or disease. METHODS: The method was developed using solid phase micro-extraction with Oasis®MAX μElution plates and Ultra Performance Liquid Chromatography to tandem mass spectrometry (UPLC-MS/MS)...
July 2, 2018: Rapid Communications in Mass Spectrometry: RCM
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