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Molecular Endocrinology

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https://www.readbyqxmd.com/read/27690770/editorial-reflections-on-the-demise-of-molecular-endocrinology-and-the-future-of-molecular-hormone-action-research
#1
Anthony R Means
No abstract text is available yet for this article.
October 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27690769/origins-of-the-field-of-molecular-endocrinology-a-personal-perspective
#2
Bert W O'Malley
No abstract text is available yet for this article.
October 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27690768/bidding-a-fond-farwell-to-molecular-endocrinology
#3
John H Nilson
No abstract text is available yet for this article.
October 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27690767/editorial-centennial-celebration-an-interview-with-professor-evan-simpson-on-hormones-and-cancer
#4
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27690766/editorial-reflections-on-the-impact-of-molecular-endocrinology-on-a-scientific-career
#5
Donald B DeFranco
No abstract text is available yet for this article.
October 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27690765/reflections-on-the-merger-of-molecular-endocrinology-and-endocrinology
#6
E Brad Thompson
No abstract text is available yet for this article.
October 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27690764/editorial-final-musings-on-the-impact-of-molecular-endocrinology
#7
Stephen R Hammes
No abstract text is available yet for this article.
October 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27690763/table-of-contents
#8
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27603413/gnrh-stimulates-peptidylarginine-deiminase-catalyzed-histone-citrullination-in-gonadotrope-cells
#9
Shaihla A Khan, Brian S Edwards, Aaron Muth, Paul R Thompson, Brian D Cherrington, Amy M Navratil
Peptidylarginine deiminase (PAD) enzymes convert histone tail arginine residues to citrulline resulting in chromatin decondensation. Our previous work found that PAD isoforms are expressed in female reproductive tissues in an estrous cycle-dependent fashion, but their role in the anterior pituitary gland is unknown. Thus, we investigated PAD expression and function in gonadotrope cells. The gonadotrope-derived LβT2 cell line strongly expresses PAD2 at the protein level compared with other PAD isoforms. Consistent with this, PAD2 protein expression is highest during the estrous phase of the estrous cycle and colocalizes with the LH β-subunit in the mouse pituitary...
October 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27571290/phosphorylation-of-farnesoid-x-receptor-at-serine-154-links-ligand-activation-with-degradation
#10
Takuyu Hashiguchi, Shingo Arakawa, Shogo Takahashi, Frank J Gonzalez, Tatsuya Sueyoshi, Masahiko Negishi
Comparison of 11 human nuclear receptor amino acid sequences revealed a conserved phosphorylation motif within their DNA-binding domains as an intramolecular signal that regulates proteolytic degradation. Nuclear receptors use this signal to either degrade or proscribe degradation through either the proteasome or nonproteasome pathways. A phosphomimetic farnesoid X receptor (FXR) S154D mutant neither bound to nor trans-activated an FXR-response element-driven reporter gene and was rapidly degraded in COS-1 cells...
October 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27533791/er%C3%AE-xpo1-cross-talk-controls-tamoxifen-sensitivity-in-tumors-by-altering-erk5-cellular-localization
#11
Kinga Wrobel, Yiru Chen Zhao, Eylem Kulkoyluoglu, Karen Lee Ann Chen, Kadriye Hieronymi, Jamie Holloway, Sarah Li, Tania Ray, Partha Sarathi Ray, Yosef Landesman, Alexander Edward Lipka, Rebecca Lee Smith, Zeynep Madak-Erdogan
Most breast cancer deaths occur in women with recurrent, estrogen receptor (ER)-α(+), metastatic tumors. There is a critical need for therapeutic approaches that include novel, targetable mechanism-based strategies by which ERα (+) tumors can be resensitized to endocrine therapies. The objective of this study was to validate a group of nuclear transport genes as potential biomarkers to predict the risk of endocrine therapy failure and to evaluate the inhibition of XPO1, one of these genes as a novel means to enhance the effectiveness of endocrine therapies...
October 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27533789/elevated-basal-insulin-secretion-in-type-2-diabetes-caused-by-reduced-plasma-membrane-cholesterol
#12
Vini Nagaraj, Abdulla S Kazim, Johan Helgeson, Clemens Lewold, Satadal Barik, Pawel Buda, Thomas M Reinbothe, Stefan Wennmalm, Enming Zhang, Erik Renström
Elevated basal insulin secretion under fasting conditions together with insufficient stimulated insulin release is an important hallmark of type 2 diabetes, but the mechanisms controlling basal insulin secretion remain unclear. Membrane rafts exist in pancreatic islet cells and spatially organize membrane ion channels and proteins controlling exocytosis, which may contribute to the regulation of insulin secretion. Membrane rafts (cholesterol and sphingolipid containing microdomains) were dramatically reduced in human type 2 diabetic and diabetic Goto-Kakizaki (GK) rat islets when compared with healthy islets...
October 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27489947/the-estrogen-receptor-%C3%AE-cistrome-beyond-breast-cancer
#13
Marjolein Droog, Mark Mensink, Wilbert Zwart
Although many tissues express estrogen receptor (ER)α, most studies focus on breast cancer where ERα occupies just a small fraction of its total repertoire of potential DNA-binding sites, based on sequence. This raises the question: Can ERα occupy these other potential binding sites in a different context? Ligands, splice variants, posttranslational modifications, and acquired mutations of ERα affect its conformation, which may alter chromatin interactions. To date, literature describes the DNA-binding sites of ERα (the ERα cistrome) in breast, endometrium, liver, and bone, in which the receptor mainly binds to enhancers...
October 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27581356/table-of-contents
#14
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27581355/editorial-board
#15
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27581354/minireview-the-link-between-er%C3%AE-corepressors-and-histone-deacetylases-in-tamoxifen-resistance-in-breast-cancer
#16
Stéphanie Légaré, Mark Basik
Approximately 70% of breast cancers express the estrogen receptor (ER)α and are treated with the ERα antagonist, tamoxifen. However, resistance to tamoxifen frequently develops in advanced breast cancer, in part due to a down-regulation of ERα corepressors. Nuclear receptor corepressors function by attenuating hormone responses and have been shown to potentiate tamoxifen action in various biological systems. Recent genomic data on breast cancers has revealed that genetic and/or genomic events target ERα corepressors in the majority of breast tumors, suggesting that the loss of nuclear receptor corepressor activity may represent an important mechanism that contributes to intrinsic and acquired tamoxifen resistance...
September 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27581353/editorial-centennial-celebration-an-interview-with-dr-myles-brown-on-women-s-health
#17
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27533790/mir-200-regulates-endometrial-development-during-early-pregnancy
#18
Patricia T Jimenez, Monica A Mainigi, R Ann Word, W Lee Kraus, Carole R Mendelson
For successful embryo implantation, endometrial stromal cells must undergo functional and morphological changes, referred to as decidualization. However, the molecular mechanisms that regulate implantation and decidualization are not well defined. Here we demonstrate that the estradiol- and progesterone-regulated microRNA (miR)-200 family was markedly down-regulated in mouse endometrial stromal cells prior to implantation, whereas zinc finger E-box binding homeobox-1 and -2 and other known and predicted targets were up-regulated...
September 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27482602/the-f0f1-atp-synthase-complex-localizes-to-membrane-rafts-in-gonadotrope-cells
#19
Krystal Allen-Worthington, Jianjun Xie, Jessica L Brown, Alexa M Edmunson, Abigail Dowling, Amy M Navratil, Kurt Scavelli, Hojean Yoon, Do-Geun Kim, Margaret S Bynoe, Iain Clarke, Mark S Roberson
Fertility in mammals requires appropriate communication within the hypothalamic-pituitary-gonadal axis and the GnRH receptor (GnRHR) is a central conduit for this communication. The GnRHR resides in discrete membrane rafts and raft occupancy is required for signaling by GnRH. The present studies use immunoprecipitation and mass spectrometry to define peptides present within the raft associated with the GnRHR and flotillin-1, a key raft marker. These studies revealed peptides from the F0F1 ATP synthase complex...
September 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/27427832/small-heterodimer-partner-nr0b2-coordinates-nutrient-signaling-and-the-circadian-clock-in-mice
#20
Nan Wu, Kang Ho Kim, Ying Zhou, Jae Man Lee, Nicole M Kettner, Jennifer L Mamrosh, Sungwoo Choi, Loning Fu, David D Moore
Circadian rhythm regulates multiple metabolic processes and in turn is readily entrained by feeding-fasting cycles. However, the molecular mechanisms by which the peripheral clock senses nutrition availability remain largely unknown. Bile acids are under circadian control and also increase postprandially, serving as regulators of the fed state in the liver. Here, we show that nuclear receptor Small Heterodimer Partner (SHP), a regulator of bile acid metabolism, impacts the endogenous peripheral clock by directly regulating Bmal1...
September 2016: Molecular Endocrinology
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