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Journal of Clinical Laboratory Analysis

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https://www.readbyqxmd.com/read/28105762/establishment-of-reference-intervals-for-complete-blood-count-parameters-during-normal-pregnancy-in-beijing
#1
Aiwei Li, Shuo Yang, Jie Zhang, Rui Qiao
OBJECTIVE: To observe the changes of complete blood count (CBC) parameters during pregnancy and establish appropriate reference intervals for healthy pregnant women. METHODS: Healthy pregnant women took the blood tests at all trimesters. All blood samples were processed on Sysmex XE-2100. The following CBC parameters were analyzed: red blood cell count (RBC), hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red blood cell distribution width (RDW), platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), white blood cell count (WBC), and leukocyte differential count...
January 20, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28105697/association-of-hematocrit-with-blood-pressure-and-hypertension
#2
Marzieh Emamian, Seyed Mahdi Hasanian, Maryam Tayefi, Moniba Bijari, Faeze Movahedian Far, Mojtaba Shafiee, Amir Avan, Alireza Heidari-Bakavoli, Mohsen Moohebati, Mahmoud Ebrahimi, Sousan Darroudi, Parvin Zamani, Mahmoud Reza Azarpazhooh, Mohsen Nematy, Mohammad Safarian, Gordon A Ferns, Habibollah Esmaeili, Mohammad Reza Parizadeh, Majid Ghayour-Mobarhan
BACKGROUND: Hypertension (HTN) is a risk factor for stroke, renal failure, and cardiovascular disease. The association between biochemical and hematological parameters with high blood pressure may provide a more precise approach to risk prediction conferred by HTN in these patients. OBJECTIVE: The aim of current study was to explore whether biochemical and hematological parameters are associated with HTN in a cohort study with a 7-year follow-up. MATERIALS AND METHODS: A total of 9808 individuals were enrolled and recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study, and biochemical and hematological factors were measured in all subjects...
January 20, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28105689/preferential-recognition-of-auto-antibodies-against-4-hydroxynonenal-modified-dna-in-the-cancer-patients
#3
Mohammad Faisal, Uzma Shahab, Abdulrahman A Alatar, Saheem Ahmad
BACKGROUND: The structural perturbations in DNA molecule may be caused by a break in a strand, a missing base from the backbone, or a chemically changed base. These alterations in DNA that occurs naturally can result from metabolic or hydrolytic processes. DNA damage plays a major role in the mutagenesis, carcinogenesis, aging and various other patho-physiological conditions. DNA damage can be induced through hydrolysis, exposure to reactive oxygen species (ROS) and other reactive carbonyl metabolites including 4-hydroxynonenal (HNE)...
January 20, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28102613/congolese-children-with-sickle-cell-trait-may-exhibit-glomerular-hyperfiltration-a-case-control-study
#4
Michel Ntetani Aloni, René Makwala Ngiyulu, Célestin Ndosimao Nsibu, Pépé Mfutu Ekulu, Jean Robert Makulo, Jean-Lambert Gini-Ehungu, Nazaire Mangani Nseka, François Bompeka Lepira
BACKGROUND: The prevalence of sickle cell trait is extremely high in sub-Saharan Africa. Recent studies have reported the impact of sickle cell carriers on renal function. However, data on renal abnormalities in children with sickle cell trait in this part of the world are unknown. In this report, we assess the glomerular function of children with sickle cell trait (SCT). METHODS: A case control study was conducted to assess the glomerular function in 43 Congolese children with sickle cell trait (Hb-AS) matched for age to 65 children with sickle cell anemia in steady state (Hb-SS) and 67 normal controls (Hb-AA)...
January 19, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28102570/simultaneous-determination-of-free-and-total-prostate-specific-antigen-by-a-magnetic-particle-based-time-resolved-fluoroimmunoassay
#5
Bin Zhou, Jue Zhang, Zhongwei Lv, Jun Fan, Yi Zhang, Biao Huang
OBJECTIVES: In this paper, a novel, sensitive and rapid method to simultaneously determine the free and total prostate-specific antigen (fPSA and tPSA) in serum by combining a time-resolved fluoroimmunoassay (TRFIA) and immunomagnetic separation was described. METHODS: The new approach uses magnetic particles as an immobilization matrix and means of separation, whereas the luminescent europium (Eu) and samarium (Sm) chelates are used as probes. The proposed method was evaluated via a single-step, sandwich-type TRFIA immunoassay of tPSA and fPSA as model analytes in serum...
January 19, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28102549/enhancing-capillary-blood-collection-the-influence-of-nicotinic-acid-and-nonivamide
#6
Christian Moro, Jessica Bass, Anna Mae Scott, Elisa F D Canetti
BACKGROUND: Nicotinic acid and nonivamide are often applied topically during capillary blood collection to induce vasodilation. These molecules may have an influence on immune effector cell activity in nearby tissues. This study investigates whether the induction of flushing by nicotinic acid and nonivamide causes an inflammatory response that influences the composition of immune cells present in a capillary blood sample. METHODS: Females aged between 18 and 30 years old provided capillary blood samples...
January 19, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28094443/validity-of-simple-clinical-and-biological-parameters-as-screening-tool-for-sickle-cell-anemia-for-referral-to-tertiary-center-in-highly-resource-constraints
#7
Bertin Tshimanga Kadima, Jean Lambert Gini-Ehungu, Fiston Ikwa Ndol Mbutiwi, John Tunda Bahati, Michel Ntetani Aloni
BACKGROUND: In the Democratic Republic of Congo, the incidence of sickle cell anemia (SCA) is estimated around 40 000 neonates per year. However, it is notoriously difficult to perform conventional electrophoresis in all hospitals and laboratories, especially at peripheral levels and rural area. A panel of multiple clinical and laboratory features that would enhance sickle cell disease were assessed for the detection of the disease in highly resource-scarce settings. METHODS: A prospective study was conducted in Kinshasa...
January 17, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28092115/fecal-calprotectin-level-in-healthy-children-aged-less-than-4%C3%A2-years-in-south-korea
#8
Joo Young Song, Yoo Mi Lee, You Jin Choi, Su Jin Jeong
BACKGROUND: Fecal calprotectin (FC) is non-invasive inflammatory marker indicating various bowel diseases. However, the median-specific cut-off values and the standard deviations (SD) of the FC levels in each age group <4 years were not elucidated. METHODS: Healthy volunteers were enrolled from four kindergartens. A questionnaire was used to confirm that the children met the inclusion criteria, and several demographics and history of bowel symptoms were collected...
January 16, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28090683/similar-but-not-consistent-revisiting-the-pitfalls-of-measuring-igg-subclasses-with-different-assays
#9
Beatrice Ludwig-Kraus, Frank Bernhard Kraus
BACKGROUND: Laboratory quantification of IgG subclasses (IgGSc) is a well-established second-line tool for differential diagnosis of immune deficiencies. However, so far there is still no internationally approved standard available for IgGSc, and different assays are prone to produce divergent results. In this study, we evaluated the comparability and equivalence of two commercially available IgGSc assays, one being the Siemens IgGSc assay on a BN ProSpec analyzer and the other being The Binding Site (TBS) IgGSc assay on a Roche cobas c502 analyzer...
January 16, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28079928/relation-of-serum-and-vitreous-nesfatin-1-concentrations-with-diabetic-retinopathy
#10
Rongfeng Dai, Guohua Deng, Zhuo Sun, Zhinan Liu, Yu Qian, Yan Han
OBJECTIVE: Nesfatin-1, belonging to adipokine family, serves as an anti-inflammatory mediator. We performed this investigation to evaluate the relation between serum and vitreous nesfatin-1 concentrations with diabetic retinopathy (DR). METHODS: This study was performed in a population of 189 diabetic patients and 48 control subjects. Diabetic patients were then divided into diabetic patients without DR, non-proliferative diabetic retinopathy (NPDR) patients, and proliferative diabetic retinopathy (PDR) patients...
January 12, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28000287/the-potential-role-of-vascular-endothelial-growth-factor-as-a-new-biomarker-in-severe-intracerebral-hemorrhage
#11
Jun Zheng, Jianping Sun, Liang Yang, Bin Zhao, Zhenzeng Fan
BACKGROUND: We studied the association between high serum levels of vascular endothelial growth factor (VEGF) and clinical outcomes of intracerebral hemorrhage (ICH) patients. METHODS: Patients were divided into group A (<20 mL), group B (20-30 mL), and group C (>30 mL) based on the bleeding amount. ICH patients were also categorized into the mild group, moderate group (16-30), and severe group (31-45) based on the National Institutes of Health Stroke Scale (NIHSS)...
December 20, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27976800/clinical-value-of-jointly-detection-serum-lactate-dehydrogenase-pleural-fluid-adenosine-deaminase-and-pleural-fluid-carcinoembryonic-antigen-in-the-identification-of-malignant-pleural-effusion
#12
Fan Zhang, Lijuan Hu, Junjun Wang, Jian Chen, Jie Chen, Yumin Wang
BACKGROUND: Limited data are available for the diagnostic value, and for the diagnostic sensitivity and specificity of joint detection of serum lactate dehydrogenase (sLDH)/pleural fluid adenosine deaminase (pADA) and pleural fluid carcinoembryonic antigen (pCEA) in malignant pleural effusion (MPE). METHODS: We collected 987 pleural effusion specimens (of which 318 were malignant pleural effusion, 374 were tubercular pleural effusion, and 295 were parapneumonic effusion specimens) from the First Affiliated Hospital of Wenzhou Medical University from July 2012 to March 2016...
December 15, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27957766/evaluation-of-a-novel-point-of-care-test-kit-absogen-%C3%A2-pct-in-semi-quantitative-measurement-of-procalcitonin-in-whole-blood
#13
Hi Jeong Kwon, Jehoon Lee, Hae-Il Park, Kyungja Han
BACKGROUND: In response to inflammation, procalcitonin plasma concentrations increase more rapidly than other acute-phase reactants and higher values are associated with severe disease. Procalcitonin measurements assist in determining whether antibiotic therapy should be used. point-of-care testing (POCT) is performed for early decision making about additional testing or therapy. The ABSOGEN(™) PCT (Bumyoungbio, Inc., Suwon, Korea) is a rapid novel semi-quantitative immunochromatographic PCT assay that analyses whole blood samples...
December 13, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27957762/serum-tnf-%C3%AE-levels-in-children-with-congenital-heart-disease-undergoing-cardiopulmonary-bypass-a-cohort-study-in-china-and-a-meta-analysis-of-the-published-literature
#14
Shu-Tian Song, Chuan-Ming Bai, Ji-Wu Zhou
OBJECTIVE: To investigate the changes in tumor necrosis factor alpha (TNF-α) serum levels after cardiopulmonary bypass (CPB) in children with congenital heart disease (CHD), followed by a meta-analysis to analyze the clinical value of TNF-α in CPB. METHODS: Our cohort study enrolled 67 CHD children, assigned into off-pump group (n=32) and CPB group (n=35). The TNF-α serum levels in two groups were detected by ELISA before the operation (T1), at the end of the operation (0 hour, T2), and after 24 hours of the operation (T3)...
December 13, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27925342/vascular-endothelial-growth-factor-g-405c-polymorphism-may-contribute-to-the-risk-of-developing-papillary-thyroid-carcinoma
#15
İlknur Bingül, Pervin Vural, Semra Doğru-Abbasoğlu, Esra Çil, Müjdat Uysal
BACKGROUND: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. Vascular endothelial growth factor (VEGF) is a mediator implicated with cell proliferation, differentiation and migration, and monocyte/macrophage chemotaxis. In present study, we aimed to investigate the relationship between VEGF gene polymorphisms (G+405C, T-460C, and A-2578C) and PTC susceptibility. METHODS: DNA was isolated from peripheral blood leukocytes of 127 patients with PTC and 203 healthy controls...
December 7, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27925303/pretreatment-neutrophil-lymphocyte-ratio-but-not-platelet-lymphocyte-ratio-has-a-prognostic-impact-in-multiple-myeloma
#16
Yanjie Li, Hujun Li, Wenjing Li, Lijin Wang, Zhiling Yan, Yao Yao, Ruosi Yao, Kailin Xu, Zhenyu Li
BACKGROUND: We evaluated the prognostic significance of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in patients with multiple myeloma (MM). METHODS: In total, we retrospectively analyzed 315 newly diagnosed MM patients and calculated NLR and PLR from the complete blood count of the untreated patients. We further assessed the role of pretreatment NLR and PLR on overall survival (OS) and progression-free survival (PFS). RESULTS: Multiple myeloma patients with high NLR (≥2) experienced shorter OS (P=...
December 7, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27925300/the-importance-of-serum-biglycan-levels-as-a-fibrosis-marker-in-patients-with-chronic-hepatitis-b
#17
Rafiye Ciftciler, Seren Ozenirler, Aysegul Atak Yucel, Mustafa Cengiz, Gulbanu Erkan, Erkan Buyukdemirci, Cemile Sönmez, Guldal Yılmaz Esendaglı
BACKGROUND: Liver biopsy is recommended in the majority of patients with chronic viral hepatitis for fibrosis evaluation. Because of the potential risks of liver biopsy, many studies related to non-invasive biomarkers of hepatic fibrosis have been performed. We aimed to assess the diagnostic value of serum biglycan as a non-invasive fibrosis marker in chronic hepatitis B patients. METHODS: This study included 120 patients with biopsy-proven hepatitis B patients and 60 healthy controls...
December 7, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27925284/extent-of-agreement-between-the-body-fluid-model-of-sysmex-xn-20-and-the-manual-microscopy-method
#18
Wei-Hua Huang, Lin-Peng Lu, Kang Wu, Fang-Yu Guo, Jie Guo, Jing-Long Yu, Dao-Yin Zhou, Yi Sun, An-Mei Deng
BACKGROUND: Although the correlations concerning cellular component analysis between the Sysmex XN-20 body fluid (BF) model and manual microscopy have been investigated by several studies, the extent of agreement between these two methods has not been investigated. METHODS: A total of 90 BF samples were prospectively collected and analyzed using the Sysmex XN-20 BF model and microscopy. The extent of agreement between these two methods was evaluated using the Bland-Altman approach...
December 7, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27911021/a-rapid-and-simple-liquid-chromatography-tandem-mass-spectrometry-method-for-the-measurement-of-testosterone-androstenedione-and-dehydroepiandrosterone-in-human-serum
#19
Wenjuan Xu, Huijun Li, Qing Guan, Ying Shen, Liming Cheng
BACKGROUND: The assay of androgens plays an important role for the differential diagnosis of androgen-related endocrine diseases. We developed a rapid and simple liquid chromatography tandem mass spectrometry (LC-MS/MS) method with small sample volume and simple sample preparation for simultaneous determination of serum testosterone, androstenedione and dehydroepiandrosterone (DHEA) in adults. METHODS: We spiked 100 μL of serum with 200 μL of internal standard solution, which was prepared in methanol, for matrix effect relief and protein precipitation...
December 2, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27910999/relationship-between-serum-cytokines-receptors-and-matrix-metalloproteinase-9-levels-and-coronary-artery-disease
#20
Seyed Reza Mirhafez, Amir Avan, Mohammad Tajfard, Shabnam Mohammadi, Mohsen Moohebati, Arash Fallah, Hamed Ghazavi, Hossein Savadi, Majid Ghayour Mobarhan
BACKGROUND: The prevalence of coronary artery disease (CAD) is increasing globally, supporting the need for the identification of novel biomarkers. Therefore in the present study, we have explored the association of SIL2A, SIL6R, STNFRI, STNFRII, and MMP9 in CAD patients. METHODS: Twenty one patients with angiographically defined CAD with more than 50% occlusion, at least, in one coronary artery and twenty healthy subjects (n=20) without the history of cardiovascular symptoms were enrolled...
December 2, 2016: Journal of Clinical Laboratory Analysis
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