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Journal of Clinical Epidemiology

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https://www.readbyqxmd.com/read/28435100/montreal-accord-on-patient-reported-outcomes-use-series-paper-5-patient-reported-outcomes-pro-can-be-linked-to-epidemiologic-measures-to-monitor-populations-and-inform-public-health-decisions
#1
Hiroshi Mamiya, Lisa M Lix, William Gardner, Susan J Bartlett, Sara Ahmed, David Buckeridge
BACKGROUND: Comprehensive picture of population health status can be captured by the incorporation of patient reported outcome measures into population health monitoring. OBJECTIVE: To identify current state, opportunities, and future research related to the utilization of patient reported outcome measures for population health monitoring in Canada. DISCUSSIONS: Patient reported outcome measures can help to identify community health needs in public health topics including injury, chronic disease, and communicable disease...
April 20, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28435099/a-meta-analysis-but-not-a-systematic-review-an-evaluation-of-the-global-bmi-mortality-collaboration
#2
Katherine M Flegal, John P A Ioannidis
Meta-analyses of individual participant data (MIPDs) offer many advantages and are considered the highest level of evidence. However, MIPDs can be seriously compromised when they are not solidly founded upon a systematic review. These data-intensive collaborative projects may be led by experts who already have deep knowledge of the literature in the field and of the results of published studies and how these results vary based on different analytical approaches. If investigators tailor the searches, eligibility criteria and analysis plan of the MIPD, they run the risk of reaching foregone conclusions...
April 20, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28433678/montreal-accord-on-patient-reported-outcomes-use-series-paper-4-patient-reported-outcomes-pro-can-inform-clinical-decision-making-in-chronic-care
#3
Clifton O Bingham, Vanessa Noonan, Claudine Auger, Debbie Feldman, Sara Ahmed, Susan J Bartlett
BACKGROUND: Providing patient-centered healthcare requires that patient needs, preferences, and valued outcomes are more fully integrated into all decisions. Patient reported outcome measures (PROs) provide unique information from the patient perspective on overall health, symptoms, burden, and treatment response. OBJECTIVE: We sought to describe applications of PROs in clinical settings and considerations for implementation from the perspectives of PRO researchers, clinicians, administrators, policy makers, and patients attending a multidisciplinary meeting...
April 19, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28433677/montreal-accord-on-patient-reported-outcomes-use-series-paper-9-anonymization-and-ethics-considerations-for-capturing-and-sharing-patient-reported-outcomes-pro
#4
L Arbuckle, E Moher, S J Bartlett, S Ahmed, K El Emam
BACKGROUND: Patient reported outcomes (PRO) are collected with consent for care, however using the data for any other purpose requires consent for that additional purpose, or the anonymization of the data. Collecting explicit consent to use this data for secondary purposes, before the patient completes a PRO, can also bias the responses. OBJECTIVE: We consider the ethical and security issues related to the collection of data at the point of care or in the population, and the aggregation and integration of PRO data with administrative databases to facilitate decision-making and comparative effectiveness research...
April 19, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28433676/dissemination-bias-in-qualitative-research-conceptual-considerations
#5
Ingrid Toews, Andrew Booth, Rigmor C Berg, Simon Lewin, Claire Glenton, Heather M Munthe-Kaas, Jane Noyes, Sara Schroter, Joerg J Meerpohl
When the findings of relevant studies are not disseminated, and are therefore not accessible, data within evidence syntheses may be considered inadequate. In addition, if non-dissemination is systematic rather than random - that is, disseminated studies and findings differ systematically from non-disseminated studies and findings - this will cause bias. Such bias could occur due to several mechanisms, and is referred to by the term dissemination bias. The presence of dissemination bias could impact on our confidence in findings from qualitative evidence syntheses...
April 19, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28433675/montreal-accord-on-patient-reported-outcomes-use-series-paper-8-patient-reported-outcomes-pro-in-electronic-health-records-can-inform-clinical-and-policy-decisions
#6
S Ahmed, P Ware, W Gardner, J Witter, C O Bingham, D Khairy, S J Bartlett
BACKGROUND: Given that the goal of healthcare systems is to improve and maintain the health of the populations they serve, the indicators of performance must include outcomes that are meaningful to patients. The growth of health technologies provides an unprecedented opportunity to integrate the patient voice into clinical care by linking electronic health records (EHR) to patient-reported outcome (PRO) data collection. However, PRO data must be relevant, meaningful, and actionable for those who will have to invest the time and effort to collect it...
April 19, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28433674/montreal-accord-on-patient-reported-outcomes-use-series-paper-6-creating-national-initiatives-to-support-patient-reported-outcomes-pro-development-and-use-the-promis-example
#7
Susan J Bartlett, James Witter, David Cella, Sara Ahmed
BACKGROUND: PRO data are beneficial to a range of stakeholders including patients, clinicians, researchers, national funding and regulatory agencies, health system administrators, and policymakers. OBJECTIVE: Because stakeholders represent diverse groups and needs, it is challenging to reach consensus on how to advance PRO development and harmonize data across settings to enable use for multiple secondary purposes. Collaborative national networks can facilitate the sharing of expertise, resources and necessary infrastructure; create development, use, and reporting standards; optimize formats to efficiently store and transfer data; and disseminate tools and information for widespread uptake...
April 19, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28433673/montreal-accord-on-patient-reported-outcomes-use-series-paper-2-terminology-proposed-to-measure-what-matters-in-health
#8
Nancy E Mayo, Sabrina Figueiredo, Sara Ahmed, Susan Bartlett
BACKGROUND: We outline different health outcomes and describe how multiple perspectives can be harnessed to optimize accuracy of key data collected about patients with chronic conditions. The terms health status, health-related quality of life, and quality of life are often used interchangeably without recognizing that they have different meanings, as are the terms used to refer to the different components of function. While the advantages and limitations of existing frameworks and perspectives are largely understood, greater precision is needed when using health outcome terminology and identifying optimal sources of information...
April 19, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28433672/montreal-accord-on-patient-reported-outcomes-use-series-paper-1-introduction
#9
Susan J Bartlett, Sara Ahmed
BACKGROUND: Patient-centered healthcare, where we design and deliver care to address the needs and preferences of patients, represents an important paradigm shift. Patient reported outcomes (PROs) are critical to capture the patient voice, understand how illness and treatments affect people, and establish how well services and treatments address what matters most to patients. OBJECTIVE: Originally developed for use in research, PROs are now used to monitor individuals and populations, manage care, evaluate services and providers, and inform policy...
April 19, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28433671/montreal-accord-on-patient-reported-outcomes-use-series-paper-3-patient-reported-outcomes-pro-can-facilitate-shared-decision-making-and-guide-self-management
#10
V K Noonan, A Lyddiatt, P Ware, S B Jaglal, R J Riopelle, C O Bingham, S Figueiredo, R Sawatzky, M Santana, S J Bartlett, S Ahmed
BACKGROUND: There is a shift towards making health care patient-centred whereby patients are part of medical decision-making and take responsibility for managing their health. Patient-reported outcomes (PROs) capture the patient voice and can be used to engage patients in medical decision-making. OBJECTIVE: The objective of this paper is to present important factors from patients', clinicians', researchers', and decision-makers' perspectives that influence successful adoption of PROs in clinical practice...
April 19, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28431916/montreal-accord-on-patient-reported-outcomes-use-series-commentary
#11
Karon F Cook, Benjamin D Schalet
No abstract text is available yet for this article.
April 18, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28428139/use-and-reporting-of-bayesian-methods-for-primary-data-analysis-in-epidemiological-research-a-systematic-review
#12
REVIEW
Charlotte Rietbergen, Thomas Pa Debray, Irene Klugkist, Kristel Jm Janssen, Karel Gm Moons
BACKGROUND: The objective of this systematic review is to investigate the use of Bayesian data analysis in epidemiology in the past decade, and particularly to evaluate the quality of research papers reporting the results of these analyses. METHODS: Complete volumes of five major epidemiological journals in the period 2005-2015 were searched via Pubmed. In addition we performed an extensive within-manuscript search using a specialized Java application. Details of reporting on Bayesian statistics were examined in original research papers with primary Bayesian data analyses...
April 17, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28412468/a-computationally-simply-central-monitoring-procedure-was-proposed-and-effectively-applied-to-empirical-trial-data-with-known-fraud
#13
Rutger M van den Bor, Petrus Wj Vaessen, Bas J Oosterman, Nicolaas Pa Zuithoff, Diederick E Grobbee, Kit Cb Roes
OBJECTIVE: Central monitoring of multi-center clinical trials becomes an ever more feasible quality assurance tool, in particular for the detection of data fabrication. More widespread application, across both industry-sponsored as well as academic clinical trials, requires central monitoring methodologies that are both effective and relatively simple in implementation. STUDY DESIGN AND SETTING: We describe a computationally simple fraud detection procedure intended to be applied repeatedly and (semi-)automatically to accumulating baseline data, to detect data fabrication in multi-center trials as early as possible...
April 12, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28412467/magnitude-and-direction-of-missing-confounders-had-different-consequences-on-treatment-effect-estimation-in-propensity-score-analysis
#14
Tri-Long Nguyen, Gary S Collins, Jessica Spence, Charles Fontaine, Jean-Pierre Daurès, P J Devereaux, Paul Landais, Yannick Le Manach
OBJECTIVE: Propensity score (PS) analysis allows an unbiased estimate of treatment effects, but assumes that all confounders are measured. We assessed the impact of omitting confounders from a PS analysis on clinical decision-making. STUDY DESIGN AND SETTING: We conducted Monte Carlo simulations on hypothetical observational studies based on virtual populations and on the population from a large randomized trial (CRASH-2). In both series of simulations, PS analysis was conducted with all confounders and with omitted confounders, which were defined to have different strengths of association with the outcome and treatment exposure...
April 12, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28412466/proposed-variations-of-the-stepped-wedge-design-can-be-employed-to-accommodate-multiple-interventions
#15
Vivian H Lyons, Lingyu Li, James P Hughes, Ali Rowhani-Rahbar
OBJECTIVE: Stepped wedge design (SWD) cluster randomized trials have traditionally been used for evaluating a single intervention. We aimed to explore design variants suitable for evaluating multiple interventions in a SWD trial. STUDY DESIGN AND SETTING: We identified four specific variants of the traditional SWD that would allow two interventions to be conducted within a single cluster randomized trial: Concurrent, Replacement, Supplementation and Factorial SWDs...
April 12, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28412465/authors-of-clinical-trials-reported-individual-and-financial-conflicts-of-interest-more-frequently-than-institutional-and-non-financial-ones-a-methodological-survey
#16
Maram B Hakoum, Nahla Jouni, Eliane A Abou-Jaoude, Divina Justina Hasbani, Elias A Abou-Jaoude, Luciane Cruz Lopes, Mariam Khaldieh, Mira Z Hammoud, Mounir Al Gibbawi, Sirine Anouti, Gordon Guyatt, Elie A Akl
BACKGROUND: Conflicts of interest (COI) are increasingly recognised as important to disclose and manage in health research. The objective of this study was to assess the reporting of both financial and non-financial COI by authors of randomised controlled trials published in a representative sample of clinical journals. METHODS: We searched Ovid Medline and included a random sample of 200 randomised controlled trials published in 2015 in one of the 119 Core Clinical Journals...
April 12, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28412464/grade-equity-guidelines-1-health-equity-in-guideline-development-introduction-and-rationale
#17
Vivian A Welch, Elie A Akl, Gord Guyatt, Kevin Pottie, Javier Eslava-Schmalbach, Mohammed T Ansari, Hans de Beer, Matthias Briel, Tony Dans, Inday Dans, Monica Hultcrantz, Janet Jull, Srinivasa Vittal Katikireddi, Joerg Meerpohl, Rachael Morton, Annhild Mosdol, Jennifer Petkovic, Holger Schünemann, Ravi Sharaf, Jasvinder Singh, Roger Stanev, Thomy Tonia, Mario Tristan, Sigurd Vitols, Joseph Watine, Peter Tugwell
OBJECTIVES: This paper introduces the rationale and methods for explicitly considering health equity in the GRADE methodology for development of clinical, public health and health system guidelines. STUDY DESIGN AND SETTING: guidance for guideline development STUDY DESIGN AND SETTING: We searched for guideline methodology papers, conceptual papers about health equity and examples of guidelines which considered health equity explicitly. We held three meetings with GRADE working group members, and invited comments from the GRADE working group listserve RESULTS: We developed three papers on incorporating equity considerations into the overall approach to guideline development, rating certainty and assembling the evidence base and evidence to decision/recommendation...
April 12, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28412463/frameworks-for-adaptation-of-health-guidelines-a-methodological-survey
#18
REVIEW
Andrea Darzi, Elias A Abou-Jaoude, Arnav Agarwal, Chantal Lakis, Wojtek Wiercioch, Nancy Santesso, Hneine Brax, Fadi El-Jardali, Holger J Schünemann, Elie A Akl
BACKGROUND: Our objective was to identify and describe published frameworks for adaptation of clinical, public health and health services guidelines. METHODS: We included reports describing methods of adaptation of guidelines in sufficient detail to allow its reproducibility. We searched Medline, and EMBASE databases. We also searched personal files, as well manuals and handbooks of organizations and professional societies that proposed methods of adaptation and adoption of guidelines...
April 12, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28411080/a-meta-analysis-of-individual-participant-data-constructed-to-align-with-prior-expert-views-comments-on-bhupathiraju-et-al
#19
Katherine M Flegal, John P A Ioannidis
No abstract text is available yet for this article.
April 11, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28411079/commentary-on-a-meta-analysis-but-not-a-systematic-review-an-evaluation-of-the-global-bmi-mortality-collaboration
#20
Shilpa N Bhupathiraju, Emanuele Di Angelantonio, John Danesh, Frank B Hu
No abstract text is available yet for this article.
April 11, 2017: Journal of Clinical Epidemiology
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