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Breast Disease

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https://www.readbyqxmd.com/read/28777747/breast-fibroadenoma-with-pseudoangiomatous-pash-like-stroma
#1
Josko Bezic, Jelena Srbljin
Pseudoangiomatous stromal hyperplasia (PASH) is a breast stromal change, histologically characterized by anastomosing, slit-like spaces lined by slender myofibroblasts and surrounded by dense collagenous stroma. Mass forming cases clinically and radiologically simulate fibroadenoma. A middle aged women presented with unpalpable breast nodule discovered on ultrasound examination. The ultrasound characteristics were typical for fibroadenoma, while fine-needle aspiration cytology was inconclusive. The histological examination of the lumpectomy specimen showed fibroadenoma with peculiar stromal alteration consistent with pseudoangiomatous stromal hyperplasia...
August 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28697552/the-importance-of-tattoo-pigment-in-sentinel-lymph-nodes
#2
Atilla Soran, Ebru Menekse, Amal Kanbour-Shakir, Kaori Tane, Emilia Diego, Marguerite Bonaventura, Ronald Johnson
BACKGROUND: The presence of pigment in axillary lymph nodes (LN) secondary to migration of tattoo ink can imitate the appearance of a blue sentinel lymph node (SLN) on visual inspection, causing the operator to either miss the true SLN or excise more than is needed. OBJECTIVE: We present patients with tattoos ipsilateral to an early stage breast cancer who underwent a SLN biopsy. METHODS: Patients were retrospectively reviewed from medical records and clinicopathologic data was collected...
July 6, 2017: Breast Disease
https://www.readbyqxmd.com/read/28655121/high-grade-poorly-differentiated-neuroendocrine-carcinoma-of-the-breast-with-low-oncotype-dx-recurrence-score-a%C3%A2-case%C3%A2-report
#3
Carlos A Munoz-Zuluaga, Sandy Kotiah, Kimberley D Studeman
Primary neuroendocrine carcinoma of the breast (NECB) is a rare malignant tumor with controversial biological behavior and a lack of data guiding treatment decisions due to its scarcity. Cancer gene-expression profiling tests provide a better indication of clinical prognosis and help determine the best clinical management versus the traditional clinical and pathological parameters. This is a report of a NECB with a genetic assay that showed a low-risk tumor despite high-grade and poorly differentiated histopathological features...
June 23, 2017: Breast Disease
https://www.readbyqxmd.com/read/28655120/a-rare-benign-tumor-of-breast-masquerading-on-fine-needle-aspiration-cytology-a%C3%A2-case%C3%A2-report
#4
Banushree Cs, Ramachandra V Bhat, Sri Vengadesh Gopal
Pleomorphic adenoma is a common tumor encountered in major salivary gland and very rarely seen in breast. This matrix producing tumor can be confused with fibroadenoma, phyllodes tumor and metaplastic carcinoma on fine needle aspiration cytology(FNAC). Pre-operative diagnosis of pleomorphic adenoma helps in preventing surgical over or under treatment of the disease. We present an extremely rare case of pleomorphic adenoma of breast diagnosed on FNAC with histopathological confirmation.
June 23, 2017: Breast Disease
https://www.readbyqxmd.com/read/28655119/follow-up-of-granulomatous-mastitis-with-monitoring-versus-surgery
#5
Hasan Çalış, Serif Melih Karabeyoglu
BACKGROUND: IGM (Idiopathic Granulomatous Mastitis) is a rare, chronic, non-malignant and non-life-threatening breast disease. Clinically and radiologically, it has similar characteristics with other granulomatous diseases and breast carcinomas. METHODS: The patients whom diagnosed IGM according to pathology report were retrospectively evaluated between November 2014 and January 2016. The demographic properties, complaints during admission, diagnosis and treatment methods and clinical results were obtained via investigation of the patient files...
June 23, 2017: Breast Disease
https://www.readbyqxmd.com/read/28655118/giant-juvenile-fibroadenoma-in-a-9-year-old-a-case-presentation-and-review-of-the-current-literature
#6
Michalina Kupsik, Brian Yep, Suela Sulo, Heidi Memmel
Juvenile fibroadenoma is the most common breast mass in adolescents accounting for 0.5-4% of all cases of fibroadenomas. Giant fibroadenomas are well-circumscribed, firm breast masses characterized by proliferation of epithelial and connective tissue. They are defined as being larger than 5 cm or weighing more than 500 g. The peak age has been reported between the ages of 17 and 20, with less than 5% of these in patients less than 18-years-old.We present a 9-year-old, pre-menstrual, Nigerian female with no known family history of breast masses or cancers who developed spontaneous giant fibroadenoma measuring approximately 13  cm × 13 cm...
June 23, 2017: Breast Disease
https://www.readbyqxmd.com/read/28655117/the-overall-5-year-survival-rate-of-breast-cancer-among-iranian-women-a-systematic-review-and-meta-analysis-of-published-studies
#7
Abbas Rezaianzadeh, Maryam Jalali, Ahmad Maghsoudi, Ali Mohammad Mokhtari, Soheil Hassanipour Azgomi, Seyedeh Leila Dehghani
INTRODUCTION: Breast Cancer (BC) is the most prevalent cancer and the second leading cause of cancer-related death among Iranian women. A valid estimation of the 5-year survival rate can improve the current BC treatment programs. The present study aimed to assess the 5-year survival rate through a systematic review of published studies. METHODS: A systematic search of Medline/PubMed, Scopus, and Science direct as well as Iranian databases was conducted to identify the original articles evaluating the 5-year survival rate of BC among women in Iran...
June 23, 2017: Breast Disease
https://www.readbyqxmd.com/read/28598829/impaired-expression-of-drosha-in-breast%C3%A2-cancer
#8
Ali Akbar Poursadegh Zonouzi, Mohammad Shekari, Azim Nejatizadeh, Samira Shakerizadeh, Hedieh Fardmanesh, Ahmad Poursadegh Zonouzi, Mohammad Rahmati-Yamchi, Majid Tozihi
BACKGROUND: Impaired miRNAs processing pathway is one interesting scenario for global downregulation of the miRNAome in various types of malignancy. We previously reported that DGCR8 and Dicer genes dysregulated in patients with breast cancer. OBJECTIVE: To evaluate the expression pattern of Drosha in patients with breast cancer. METHODS: We evaluated the mRNA expression level of Drosha in 70 fresh breast carcinomas and adjacent non-neoplastic tissue using quantitative real-time PCR and assessed the possible correlation between its expression and clinicopathological parameters...
June 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28598828/gigantomastia-due-to-retromammary-lipoma-an-aesthetic-management
#9
Sandipan Gupta, Debarati Chattopadhyay, Souradip Gupta, Akhilesh Agarwal, Gautam Guha
INTRODUCTION: A "giant" lipoma is defined as a tumor having dimensions greater than 10 cm. Giant lipomas are rare and giant breast lipomas are exceptionally uncommon. Only six cases have been described in world literature till date. Herein we describe a case of giant breast lipoma and discuss its surgical management. CASE REPORT: A 43-year-old lady presented with left sided unilateral gigantomastia. Clinical examination, radiology and histopathology diagnosed lipoma...
June 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28598827/expression-analysis-of-long-non-coding-atb-and-its-putative-target-in-breast-cancer
#10
Elahe Nikpayam, Mohammad Soudyab, Behnoosh Tasharrofi, Shaghayegh Sarrafzadeh, Mostafa Iranpour, Lobat Geranpayeh, Reza Mirfakhraie, Jalal Gharesouran, Soudeh Ghafouri-Fard
BACKGROUND: A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) has been recently shown to promote the invasion-metastasis cascade in various types of cancers via upregulation of some targets including ZEB1. OBJECTIVES: The aim of the present study was to elucidate the expression of lncRNA-ATB and ZEB in breast cancer patients. METHODS: The expression of these genes was evaluated by real-time reverse transcription polymerase chain reaction in tumor samples form 50 newly diagnosed breast cancer patients as well as their corresponding adjacent non-cancerous tissues (ANCTs)...
June 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28598826/the-evaluation-of-the-effect-of-metformin-on-breast-fibrocystic-disease
#11
A Talaei, A Moradi, F Rafiei
No abstract text is available yet for this article.
June 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28598825/retinoic-acid-related-orphan-receptor-alpha-rora-variants-and-risk-of-breast-cancer
#12
Mohammad Taheri, Mir Davood Omrani, Rezvan Noroozi, Shaghayegh Sarrafzadeh, Soudeh Ghafouri-Fard, Arezou Sayad
BACKGROUND: Breast cancer is the most common type of cancer and the second leading cause of cancer death in females. Despite numerous studies in this field, the etiology and clinical behavior of breast tumors have not been understood yet. Retinoid orphan nuclear receptor alpha (RORA) is a member of the orphan nuclear factor family involved in the regulation of lipid and steroid metabolism, immune response and circadian rhythms. Recent evidences support its role as a tumor suppressor gene...
June 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28269736/huge-lactating-adenoma-of-the-breast-case-report
#13
Islam A Elzahaby, Saleh Saleh, Islam H Metwally, Adel Fathi, Khaled Atallah
No abstract text is available yet for this article.
March 3, 2017: Breast Disease
https://www.readbyqxmd.com/read/28035906/neutrophil-lymphocyte-ratio-and-platelet-lymphocyte-ratio-as-prognostic-factors-in-non-metastatic-breast-cancer-patients-from-a-hispanic-population
#14
Ramos-Esquivel Allan, Rodriguez-Porras Luis, Porras Juan
No abstract text is available yet for this article.
December 29, 2016: Breast Disease
https://www.readbyqxmd.com/read/28035905/a-rare-case-of-umbilical-metastasis-after-delayed-transverse-rectus-abdominis-myocutaneous-flap-reconstruction-for-invasive-breast-cancer
#15
Nicky Claire Seymour, Rathi Rathinaezhil
A 46-year-old female presented with an inflamed and painful umbilicus. Past medical history included breast cancer, followed by metastatic sternal cancer two years after the initial breast cancer diagnosis.The painful umbilicus was confirmed metastasis from a primary breast cancer she had treated eleven years previously.Metastases to the umbilicus are rare, and are usually gastrointestinal in origin. To our knowledge this is the first report of a metastasis from any primary cancer to the umbilicus after transverse rectus abdominis myocutaneous flap (TRAM)...
December 29, 2016: Breast Disease
https://www.readbyqxmd.com/read/27983521/expression-of-ttf-1-in-breast-cancer-independently-of-er-expression-a-case-report-and-pathogenic-implications
#16
Ioannis A Voutsadakis, Paul Mozarowski
Thyroid Transcription Factor 1 (TTF-1) is often used for the immunohistochemical evaluation of lung cancers, as a significant proportion of these cancers are positive while other adenocarcinomas are usually negative. Breast cancers are known to express TTF-1 only in a small minority of cases but this may be problematic when this staining is used for its differential diagnosis from lung cancer. We present a case of ER-positive breast cancer in 30% of tumor cells that was also TTF-1 positive in some areas of the primary tumor but lost ER expression completely in the metastatic recurrence site while retaining TTF-1 positivity...
December 14, 2016: Breast Disease
https://www.readbyqxmd.com/read/27662275/crystallizing-galactocele-report-of-a-rare-variation
#17
Archana Shetty, Aparna Narasimha, V J Jayalakshmi
The physiological changes of the breast during pregnancy and lactation make the clinical, radiological and pathological evaluation of a breast mass challenging. Galactoceles are benign lesions containing milk, and generally occur post partum. Fine needle aspiration cytology is a simple, quick and effective technique for the diagnosis of the same during this period, and in case of galactocele the same can be both diagnostic and therapeutic.Although the cytological features of galactocele are straight forward, a few rare interesting variations can be encountered posing a diagnostic challenge to the reporting cytopathologist...
July 28, 2016: Breast Disease
https://www.readbyqxmd.com/read/27662274/alcohol-consumption-and-mortality-after-breast-cancer-diagnosis-the-health-and-functioning-in-women-study
#18
Natasha Din, Isabel Elaine Allen, William A Satariano, Joshua Demb, Dejana Braithwaite
OBJECTIVE: To determine the association of prediagnostic alcohol consumption with long-term mortality from breast cancer and other causes in a cohort of women with breast cancer. METHODS: We studied a Michigan-based cohort of 939 women aged 40-84 years, who provided complete information about the type, amount and intensity of prediagnostic alcohol consumption. Associations of alcohol consumption, based on weekly volume of alcohol consumption during the year prior to breast cancer diagnosis, with mortality were evaluated in Cox proportional hazards models, with adjustment for sociodemographic factors, body mass index, smoking, comorbidity, tumor characteristics, and treatment...
July 28, 2016: Breast Disease
https://www.readbyqxmd.com/read/27662273/bioimpedance-to-screen-for-abdominal-fat-in-patients-with-breast-cancer-treatment-related-lymphedema
#19
Maria de Fátima Guerreiro Godoy, Edivandra Buzato Silva, Jose Maria Pereira de Godoy
BACKGROUND: One of the dreaded complications after the treatment of breast cancer is lymphedema. Therapies used in the treatment of breast cancer such as surgery, radiotherapy, hormone therapy and chemotherapy may be adversely affected by obesity. AIM: The objective of this study was to use bioimpedance to assess abdominal fat in women with breast cancer treatment-related lymphedema and suggest this as a screening method. METHODS: Forty-five female patients with clinical diagnosis of breast cancer treatment-related lymphedema were evaluated in this quantitative cross-sectional study...
July 28, 2016: Breast Disease
https://www.readbyqxmd.com/read/27662272/the-impact-of-oncotype-dx%C3%A2-%C3%A2-recurrence-score-of-paraffin-embedded-core-biopsy-tissues-in-predicting-response-to-neoadjuvant-chemotherapy-in-women-with-breast-cancer
#20
Atilla Soran, Rohit Bhargava, Ronald Johnson, Gretchen Ahrendt, Marguerite Bonaventura, Emilia Diego, Priscilla F McAuliffe, Merida Serrano, Ebru Menekse, Efe Sezgin, Kandace P McGuire
BACKGROUND: Oncotype DX® test is beneficial in predicting recurrence free survival in estrogen receptor positive (ER+) breast cancer. Ability of the assay to predict response to neoadjuvant chemotherapy (NCT) is less well-studied. OBJECTIVE: We hypothesize a positive association between the Oncotype DX® recurrence score (RS) and the percentage tumor response (%TR) after NCT. METHODS: Pre-therapy RS was measured on core biopsies from 60 patients with ER+, HER2- invasive breast cancer (IBC) who then received NCT...
July 28, 2016: Breast Disease
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