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Breast Disease

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https://www.readbyqxmd.com/read/28598829/impaired-expression-of-drosha-in-breast%C3%A2-cancer
#1
Ali Akbar Poursadegh Zonouzi, Mohammad Shekari, Azim Nejatizadeh, Samira Shakerizadeh, Hedieh Fardmanesh, Ahmad Poursadegh Zonouzi, Mohammad Rahmati-Yamchi, Majid Tozihi
BACKGROUND: Impaired miRNAs processing pathway is one interesting scenario for global downregulation of the miRNAome in various types of malignancy. We previously reported that DGCR8 and Dicer genes dysregulated in patients with breast cancer. OBJECTIVE: To evaluate the expression pattern of Drosha in patients with breast cancer. METHODS: We evaluated the mRNA expression level of Drosha in 70 fresh breast carcinomas and adjacent non-neoplastic tissue using quantitative real-time PCR and assessed the possible correlation between its expression and clinicopathological parameters...
June 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28598828/gigantomastia-due-to-retromammary-lipoma-an-aesthetic-management
#2
Sandipan Gupta, Debarati Chattopadhyay, Souradip Gupta, Akhilesh Agarwal, Gautam Guha
INTRODUCTION: A "giant" lipoma is defined as a tumor having dimensions greater than 10 cm. Giant lipomas are rare and giant breast lipomas are exceptionally uncommon. Only six cases have been described in world literature till date. Herein we describe a case of giant breast lipoma and discuss its surgical management. CASE REPORT: A 43-year-old lady presented with left sided unilateral gigantomastia. Clinical examination, radiology and histopathology diagnosed lipoma...
June 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28598827/expression-analysis-of-long-non-coding-atb-and-its-putative-target-in-breast-cancer
#3
Elahe Nikpayam, Mohammad Soudyab, Behnoosh Tasharrofi, Shaghayegh Sarrafzadeh, Mostafa Iranpour, Lobat Geranpayeh, Reza Mirfakhraie, Jalal Gharesouran, Soudeh Ghafouri-Fard
BACKGROUND: A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) has been recently shown to promote the invasion-metastasis cascade in various types of cancers via upregulation of some targets including ZEB1. OBJECTIVES: The aim of the present study was to elucidate the expression of lncRNA-ATB and ZEB in breast cancer patients. METHODS: The expression of these genes was evaluated by real-time reverse transcription polymerase chain reaction in tumor samples form 50 newly diagnosed breast cancer patients as well as their corresponding adjacent non-cancerous tissues (ANCTs)...
June 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28598826/the-evaluation-of-the-effect-of-metformin-on-breast-fibrocystic-disease
#4
A Talaei, A Moradi, F Rafiei
No abstract text is available yet for this article.
June 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28598825/retinoic-acid-related-orphan-receptor-alpha-rora-variants-and-risk-of-breast-cancer
#5
Mohammad Taheri, Mir Davood Omrani, Rezvan Noroozi, Shaghayegh Sarrafzadeh, Soudeh Ghafouri-Fard, Arezou Sayad
BACKGROUND: Breast cancer is the most common type of cancer and the second leading cause of cancer death in females. Despite numerous studies in this field, the etiology and clinical behavior of breast tumors have not been understood yet. Retinoid orphan nuclear receptor alpha (RORA) is a member of the orphan nuclear factor family involved in the regulation of lipid and steroid metabolism, immune response and circadian rhythms. Recent evidences support its role as a tumor suppressor gene...
June 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28269736/huge-lactating-adenoma-of-the-breast-case-report
#6
Islam A Elzahaby, Saleh Saleh, Islam H Metwally, Adel Fathi, Khaled Atallah
No abstract text is available yet for this article.
March 3, 2017: Breast Disease
https://www.readbyqxmd.com/read/28035906/neutrophil-lymphocyte-ratio-and-platelet-lymphocyte-ratio-as-prognostic-factors-in-non-metastatic-breast-cancer-patients-from-a-hispanic-population
#7
Ramos-Esquivel Allan, Rodriguez-Porras Luis, Porras Juan
No abstract text is available yet for this article.
December 29, 2016: Breast Disease
https://www.readbyqxmd.com/read/28035905/a-rare-case-of-umbilical-metastasis-after-delayed-transverse-rectus-abdominis-myocutaneous-flap-reconstruction-for-invasive-breast-cancer
#8
Nicky Claire Seymour, Rathi Rathinaezhil
A 46-year-old female presented with an inflamed and painful umbilicus. Past medical history included breast cancer, followed by metastatic sternal cancer two years after the initial breast cancer diagnosis.The painful umbilicus was confirmed metastasis from a primary breast cancer she had treated eleven years previously.Metastases to the umbilicus are rare, and are usually gastrointestinal in origin. To our knowledge this is the first report of a metastasis from any primary cancer to the umbilicus after transverse rectus abdominis myocutaneous flap (TRAM)...
December 29, 2016: Breast Disease
https://www.readbyqxmd.com/read/27983521/expression-of-ttf-1-in-breast-cancer-independently-of-er-expression-a-case-report-and-pathogenic-implications
#9
Ioannis A Voutsadakis, Paul Mozarowski
Thyroid Transcription Factor 1 (TTF-1) is often used for the immunohistochemical evaluation of lung cancers, as a significant proportion of these cancers are positive while other adenocarcinomas are usually negative. Breast cancers are known to express TTF-1 only in a small minority of cases but this may be problematic when this staining is used for its differential diagnosis from lung cancer. We present a case of ER-positive breast cancer in 30% of tumor cells that was also TTF-1 positive in some areas of the primary tumor but lost ER expression completely in the metastatic recurrence site while retaining TTF-1 positivity...
December 14, 2016: Breast Disease
https://www.readbyqxmd.com/read/27662275/crystallizing-galactocele-report-of-a-rare-variation
#10
Archana Shetty, Aparna Narasimha, V J Jayalakshmi
The physiological changes of the breast during pregnancy and lactation make the clinical, radiological and pathological evaluation of a breast mass challenging. Galactoceles are benign lesions containing milk, and generally occur post partum. Fine needle aspiration cytology is a simple, quick and effective technique for the diagnosis of the same during this period, and in case of galactocele the same can be both diagnostic and therapeutic.Although the cytological features of galactocele are straight forward, a few rare interesting variations can be encountered posing a diagnostic challenge to the reporting cytopathologist...
July 28, 2016: Breast Disease
https://www.readbyqxmd.com/read/27662274/alcohol-consumption-and-mortality-after-breast-cancer-diagnosis-the-health-and-functioning-in-women-study
#11
Natasha Din, Isabel Elaine Allen, William A Satariano, Joshua Demb, Dejana Braithwaite
OBJECTIVE: To determine the association of prediagnostic alcohol consumption with long-term mortality from breast cancer and other causes in a cohort of women with breast cancer. METHODS: We studied a Michigan-based cohort of 939 women aged 40-84 years, who provided complete information about the type, amount and intensity of prediagnostic alcohol consumption. Associations of alcohol consumption, based on weekly volume of alcohol consumption during the year prior to breast cancer diagnosis, with mortality were evaluated in Cox proportional hazards models, with adjustment for sociodemographic factors, body mass index, smoking, comorbidity, tumor characteristics, and treatment...
July 28, 2016: Breast Disease
https://www.readbyqxmd.com/read/27662273/bioimpedance-to-screen-for-abdominal-fat-in-patients-with-breast-cancer-treatment-related-lymphedema
#12
Maria de Fátima Guerreiro Godoy, Edivandra Buzato Silva, Jose Maria Pereira de Godoy
BACKGROUND: One of the dreaded complications after the treatment of breast cancer is lymphedema. Therapies used in the treatment of breast cancer such as surgery, radiotherapy, hormone therapy and chemotherapy may be adversely affected by obesity. AIM: The objective of this study was to use bioimpedance to assess abdominal fat in women with breast cancer treatment-related lymphedema and suggest this as a screening method. METHODS: Forty-five female patients with clinical diagnosis of breast cancer treatment-related lymphedema were evaluated in this quantitative cross-sectional study...
July 28, 2016: Breast Disease
https://www.readbyqxmd.com/read/27662272/the-impact-of-oncotype-dx%C3%A2-%C3%A2-recurrence-score-of-paraffin-embedded-core-biopsy-tissues-in-predicting-response-to-neoadjuvant-chemotherapy-in-women-with-breast-cancer
#13
Atilla Soran, Rohit Bhargava, Ronald Johnson, Gretchen Ahrendt, Marguerite Bonaventura, Emilia Diego, Priscilla F McAuliffe, Merida Serrano, Ebru Menekse, Efe Sezgin, Kandace P McGuire
BACKGROUND: Oncotype DX® test is beneficial in predicting recurrence free survival in estrogen receptor positive (ER+) breast cancer. Ability of the assay to predict response to neoadjuvant chemotherapy (NCT) is less well-studied. OBJECTIVE: We hypothesize a positive association between the Oncotype DX® recurrence score (RS) and the percentage tumor response (%TR) after NCT. METHODS: Pre-therapy RS was measured on core biopsies from 60 patients with ER+, HER2- invasive breast cancer (IBC) who then received NCT...
July 28, 2016: Breast Disease
https://www.readbyqxmd.com/read/27612041/incidental-unilateral-and-bilateral-ductal-carcinoma-in-situ-encountered-in-the-surgical-management-of-young-male-gynecomastia
#14
Bader Hamza Shirah, Hamza Assad Shirah
BACKGROUND: The increased risk for malignant tumors associated with male gynecomastia has been well established and many authors have reported cases of concurrent gynecomastia and ductal carcinoma in situ (DCIS) in the same breast. Synchronous bilateral breast cancer in association with gynecomastia is exceptionally rare. We aim to report and evaluate the management outcome of 5 cases of gynecomastia associated with DCIS (1 bilateral and 4 unilateral). METHODS: A retrospective database analysis of the surgical treatment outcome of 74 male patients who had gynecomastia was done...
July 28, 2016: Breast Disease
https://www.readbyqxmd.com/read/27612040/sunitinib-alone-or-in-combination-with-chemotherapy-for-the-treatment-of-advanced-breast-cancer-a-systematic-review-and-meta-analysis
#15
REVIEW
Ahmed Elgebaly, Ahmed Menshawy, Gehad El Ashal, Omnya Osama, Esraa Ghanem, Ahmed Omar, Ahmed Negida
INTRODUCTION: Sunitinib is an orally delivered tyrosine kinase inhibitor that exhibits antiangiogenic effects. FDA has approved sunitinib for the treatment of metastatic renal cell carcinoma. However, its efficacy for the treatment of advanced breast cancer (ABC) remains controversial. Therefore, we performed this systematic review and meta-analysis to synthesize evidence from published randomized controlled trials (RCTs) about the efficacy of sunitinib alone and in combination with chemotherapy for the treatment of ABC...
July 28, 2016: Breast Disease
https://www.readbyqxmd.com/read/27177343/envisioning-metastasis-as-a-transdifferentiation-phenomenon-clarifies-discordant-results-on-cancer
#16
Charly Jehanno, Gilles Flouriot, Floriane Nicol-Benoît, Yann Le Page, Pascale Le Goff, Denis Michel
Cancer is generally conceived as a dedifferentiation process in which quiescent post-mitotic differentiated cells acquire stem-like properties and the capacity to proliferate. This view holds for the initial stages of carcinogenesis but is more questionable for advanced stages when the cells can transdifferentiate into the contractile phenotype associated to migration and metastasis. Singularly from this perspective, the hallmark of the most aggressive cancers would correspond to a genuine differentiation status, even if it is different from the original one...
February 17, 2016: Breast Disease
https://www.readbyqxmd.com/read/27177342/evaluation-of-therapeutic-mammoplasty-techniques-in-the-surgical-management-of-female-patients-with-idiopathic-granulomatous-mastitis-with-mild-to-moderate-inflammatory-symptoms-in-terms-of-recurrence-and-patients-satisfaction
#17
Yasser S Ahmed, Walid Abd El Maksoud
BACKGROUND: Although idiopathic granulomatous mastitis (IGM) affects young females, its surgical management usually leads to disfigurement of the breasts. OBJECTIVES: To assess the use of therapeutic mammoplasty techniques for management of IGM in terms of recurrence and postoperative patients' satisfaction. METHODS: This prospective clinical study included thirteen patients who were diagnosed histologically as IGM. Patients with moderate to large breasts, who had a breast mass between 20-50% of the breast size with failed medical treatment or intolerability to steroids were subjected to therapeutic mammoplasty techniques...
February 17, 2016: Breast Disease
https://www.readbyqxmd.com/read/27177341/enhancing-patterns-of-breast-cancer-on-preoperative-dynamic-contrast-enhanced-magnetic-resonance-imaging-and-resection-margin-in-breast-conserving-therapy
#18
Ok Hwa Kim, Suk Jung Kim, Jung Sun Lee
BACKGROUND: The association between enhancing patterns of preoperative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and resection margins after BCS has not been studied in detail before. OBJECTIVE: We investigated the association between surgical outcomes and enhancing patterns observed on DCE-MRI. METHODS: 269 enhancing patterns on DCE-MRI scans were selected, and subdivided into the following groups: (1) a single mass-like enhancement, (2) a single non-mass-like enhancement (NME), (3) mass-like enhancing breast cancer with other mass-like enhancing lesions, and (4) mass-like enhancing breast cancer with additional NMEs...
February 17, 2016: Breast Disease
https://www.readbyqxmd.com/read/27177344/malignant-phyllodes-tumor-in-an-11-year-old-girl-with-fatal-clinical-outcome-a-case-report
#19
Sidra Hassan, Nasir Ud Din, Naila Kayani
BACKGROUND: Phyllodes tumors are rare biphasic tumors occur predominantly in middle aged women. Malignant phyllodes tumor in children is very rare. OBJECTIVE: To report a case of malignant phyllodes tumor in a pre-menarchal girl. METHODS: H&E slides of the case were reviewed and follow up was obtained. RESULTS: The patient was 11-year-old girl who noticed a lump in her right breast 1 year back which grew rapidly in size...
January 27, 2016: Breast Disease
https://www.readbyqxmd.com/read/27177339/clinico-epidemiological-profile-of-breast-cancer-patients-and-the-retrospective-application-of-gail-model-2-an-indian-perspective
#20
Shaji Thomas, Gunjan Desai, Om Prakash Pathania, Manjula Jain, Lalit Aggarwal, Shadan Ali, Kartikeya Sharma, Sanjeev Kumar Tudu
AIM: To study the clinical and epidemiological profile of patients of breast cancer presenting at our center at New Delhi, India and to evaluate the applicability of Gail model 2 as a means of measuring 5-year and lifetime risk in our already diagnosed cases of breast cancer. METHODS: This was a retrospective study conducted at Lady Hardinge Medical College Hospital in New Delhi, India, between January 2011 and July 2014. Two hundred and twenty two diagnosed cases of breast cancer were included...
January 27, 2016: Breast Disease
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