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Breast Disease

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https://www.readbyqxmd.com/read/29332027/phyllodes-tumors-of-the-breast-clinicopathological-analysis-of-106-cases-from-a-single-institution
#1
Boubacar Efared
BACKGROUND: Phyllodes tumors (PT) are uncommon biphasic tumors, accounting for less than 1% of all breast primary neoplasms. They form a wide variety of tumors ranging from benign to malignant. Several histological features are used to grade PT into 3 categories: benign (grade I), borderline (grade II) and malignant (grade III) tumors. The aim of our study was to analyse histolopathological, radiological and clinical features of PT from an experience of a single center. METHODS: It was a retrospective study including 106 patients diagnosed with phyllodes tumors on surgical specimens at the department of pathology, of Hassan II university hospital (Fez, Morocco), from 2009 to 2016...
January 10, 2018: Breast Disease
https://www.readbyqxmd.com/read/29286912/cytological-diagnosis-of-crystallizing-galactocele-report-of-an-unusual-case
#2
Mohammad Jaseem Hassan, Monika Sharma, Shaan Khetrapal, Sabina Khan, Sujata Jetley
Crystallizing galactocele is a very rare entity which yields a viscous, chalky material on Fine Needle Aspiration Cytology (FNAC). FNAC is used both for diagnosis as well as treatment of this condition. We present here a case of 26 years old lactating female who presented with swelling in the right breast for 8 months. The swelling was firm, discrete, non-tender and mobile involving the upper inner quadrant of right breast. A diagnosis of benign breast disease, possibly fibroadenoma was made clinically. FNAC of the lesion yielded thick, milky and chalky material...
December 28, 2017: Breast Disease
https://www.readbyqxmd.com/read/29286911/primary-breast-angiosarcoma-a-single-institution-experience-from-a-tertiary-cancer-center-in-south%C3%A2-india
#3
D Lokanatha, Abhishek Anand, K C Lakshmaiah, K Govind Babu, Linu Abraham Jacob, M C Suresh Babu, K N Lokesh, A H Rudresha, L K Rajeev, Smitha C Saldanha, G V Giri, Deepak Koppaka, Rekha V Kumar
INTRODUCTION: Primary angiosarcoma of the breast is a rare entity with incidence of less than 0.05% of all malignant breast neoplasms. It occurs in young females without any associated risk factors. The tumor behaves aggressively and has a poor prognosis compared to invasive ductal carcinoma. METHOD: It was a retrospective observational study done at a tertiary cancer center from January 2012 to December 2016. The medical records of patients diagnosed with primary breast angiosarcoma were reviewed for the study...
December 28, 2017: Breast Disease
https://www.readbyqxmd.com/read/29171964/first-site-of-recurrence-after-breast-cancer-adjuvant-treatment-in-the-era-of-multimodality-therapy-which-imaging-for-which-patient-during-follow-up
#4
Mejri Nesrine, Benna Mehdi, El Benna Houda, Labidi Soumaya, Afrit Mehdi, Zouari Bechir, Boussen Hamouda
PURPOSE: We evaluated the relation between first site of recurrence of early breast cancer and disease profile at presentation and reported survival results, suggesting a personalized diagnostic imaging guidance during follow up. METHODS: Among 1400 early breast cancer treated from 2000 to 2010, 324 relapses were divided into 4 groups according to first site: A-locoregional, B-bone, C-Brain and D-visceral. We analyzed redictive factors of each group compared to a control group of 100 non relapsing patients and the remaining groups matched...
November 21, 2017: Breast Disease
https://www.readbyqxmd.com/read/28984579/follow-up-of-patients-undergoing-oncoplastic-surgery-more-palpable-masses-and-benign-biopsies
#5
Yoav Amitai, Orit Golan, Yoav Barnea, Joseph Klausner, Tehillah S Menes
BACKGROUND: Oncoplastic reconstruction is increasingly used in the management of women undergoing breast conserving surgery. We examined the findings on breast exam and imaging of patients who underwent breast conservation with or without oncoplastic reconstruction. OBJECTIVE: We hypothesized that patients undergoing immediate breast reconstruction would present with more palpable and imaging abnormalities compared to lumpectomy alone and undergo therefore more biopsies...
October 3, 2017: Breast Disease
https://www.readbyqxmd.com/read/28854486/analysis-of-patient-detected-breast-cancer-recurrence
#6
Trishul Kapoor, Sean Wrenn, Peter Callas, Ted A James
BACKGROUND: After primary surgical resection, breast cancer survivors regularly undergo surveillance using multiple modalities to detect recurrences. OBJECTIVE: The goal of this study was to determine how breast cancer recurrences were detected in our sample population of breast cancer survivors. We hypothesize that the majority of recurrences are patient-detected. METHODS: This was a retrospective observational study evaluating patients with a detected breast cancer recurrence between 2010 and 2015...
August 24, 2017: Breast Disease
https://www.readbyqxmd.com/read/28777747/breast-fibroadenoma-with-pseudoangiomatous-pash-like-stroma
#7
Josko Bezic, Jelena Srbljin
Pseudoangiomatous stromal hyperplasia (PASH) is a breast stromal change, histologically characterized by anastomosing, slit-like spaces lined by slender myofibroblasts and surrounded by dense collagenous stroma. Mass forming cases clinically and radiologically simulate fibroadenoma. A middle aged women presented with unpalpable breast nodule discovered on ultrasound examination. The ultrasound characteristics were typical for fibroadenoma, while fine-needle aspiration cytology was inconclusive. The histological examination of the lumpectomy specimen showed fibroadenoma with peculiar stromal alteration consistent with pseudoangiomatous stromal hyperplasia...
August 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28697552/the-importance-of-tattoo-pigment-in-sentinel-lymph-nodes
#8
Atilla Soran, Ebru Menekse, Amal Kanbour-Shakir, Kaori Tane, Emilia Diego, Marguerite Bonaventura, Ronald Johnson
BACKGROUND: The presence of pigment in axillary lymph nodes (LN) secondary to migration of tattoo ink can imitate the appearance of a blue sentinel lymph node (SLN) on visual inspection, causing the operator to either miss the true SLN or excise more than is needed. OBJECTIVE: We present patients with tattoos ipsilateral to an early stage breast cancer who underwent a SLN biopsy. METHODS: Patients were retrospectively reviewed from medical records and clinicopathologic data was collected...
July 6, 2017: Breast Disease
https://www.readbyqxmd.com/read/28655121/high-grade-poorly-differentiated-neuroendocrine-carcinoma-of-the-breast-with-low-oncotype-dx-recurrence-score-a%C3%A2-case%C3%A2-report
#9
Carlos A Munoz-Zuluaga, Sandy Kotiah, Kimberley D Studeman
Primary neuroendocrine carcinoma of the breast (NECB) is a rare malignant tumor with controversial biological behavior and a lack of data guiding treatment decisions due to its scarcity. Cancer gene-expression profiling tests provide a better indication of clinical prognosis and help determine the best clinical management versus the traditional clinical and pathological parameters. This is a report of a NECB with a genetic assay that showed a low-risk tumor despite high-grade and poorly differentiated histopathological features...
June 23, 2017: Breast Disease
https://www.readbyqxmd.com/read/28655120/a-rare-benign-tumor-of-breast-masquerading-on-fine-needle-aspiration-cytology-a%C3%A2-case%C3%A2-report
#10
Banushree Cs, Ramachandra V Bhat, Sri Vengadesh Gopal
Pleomorphic adenoma is a common tumor encountered in major salivary gland and very rarely seen in breast. This matrix producing tumor can be confused with fibroadenoma, phyllodes tumor and metaplastic carcinoma on fine needle aspiration cytology(FNAC). Pre-operative diagnosis of pleomorphic adenoma helps in preventing surgical over or under treatment of the disease. We present an extremely rare case of pleomorphic adenoma of breast diagnosed on FNAC with histopathological confirmation.
June 23, 2017: Breast Disease
https://www.readbyqxmd.com/read/28655119/follow-up-of-granulomatous-mastitis-with-monitoring-versus-surgery
#11
Hasan Çalış, Serif Melih Karabeyoglu
BACKGROUND: IGM (Idiopathic Granulomatous Mastitis) is a rare, chronic, non-malignant and non-life-threatening breast disease. Clinically and radiologically, it has similar characteristics with other granulomatous diseases and breast carcinomas. METHODS: The patients whom diagnosed IGM according to pathology report were retrospectively evaluated between November 2014 and January 2016. The demographic properties, complaints during admission, diagnosis and treatment methods and clinical results were obtained via investigation of the patient files...
June 23, 2017: Breast Disease
https://www.readbyqxmd.com/read/28655118/giant-juvenile-fibroadenoma-in-a-9-year-old-a-case-presentation-and-review-of-the-current-literature
#12
Michalina Kupsik, Brian Yep, Suela Sulo, Heidi Memmel
Juvenile fibroadenoma is the most common breast mass in adolescents accounting for 0.5-4% of all cases of fibroadenomas. Giant fibroadenomas are well-circumscribed, firm breast masses characterized by proliferation of epithelial and connective tissue. They are defined as being larger than 5 cm or weighing more than 500 g. The peak age has been reported between the ages of 17 and 20, with less than 5% of these in patients less than 18-years-old.We present a 9-year-old, pre-menstrual, Nigerian female with no known family history of breast masses or cancers who developed spontaneous giant fibroadenoma measuring approximately 13  cm × 13 cm...
June 23, 2017: Breast Disease
https://www.readbyqxmd.com/read/28655117/the-overall-5-year-survival-rate-of-breast-cancer-among-iranian-women-a-systematic-review-and-meta-analysis-of-published-studies
#13
Abbas Rezaianzadeh, Maryam Jalali, Ahmad Maghsoudi, Ali Mohammad Mokhtari, Soheil Hassanipour Azgomi, Seyedeh Leila Dehghani
INTRODUCTION: Breast Cancer (BC) is the most prevalent cancer and the second leading cause of cancer-related death among Iranian women. A valid estimation of the 5-year survival rate can improve the current BC treatment programs. The present study aimed to assess the 5-year survival rate through a systematic review of published studies. METHODS: A systematic search of Medline/PubMed, Scopus, and Science direct as well as Iranian databases was conducted to identify the original articles evaluating the 5-year survival rate of BC among women in Iran...
June 23, 2017: Breast Disease
https://www.readbyqxmd.com/read/28598829/impaired-expression-of-drosha-in-breast%C3%A2-cancer
#14
Ali Akbar Poursadegh Zonouzi, Mohammad Shekari, Azim Nejatizadeh, Samira Shakerizadeh, Hedieh Fardmanesh, Ahmad Poursadegh Zonouzi, Mohammad Rahmati-Yamchi, Majid Tozihi
BACKGROUND: Impaired miRNAs processing pathway is one interesting scenario for global downregulation of the miRNAome in various types of malignancy. We previously reported that DGCR8 and Dicer genes dysregulated in patients with breast cancer. OBJECTIVE: To evaluate the expression pattern of Drosha in patients with breast cancer. METHODS: We evaluated the mRNA expression level of Drosha in 70 fresh breast carcinomas and adjacent non-neoplastic tissue using quantitative real-time PCR and assessed the possible correlation between its expression and clinicopathological parameters...
June 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28598828/gigantomastia-due-to-retromammary-lipoma-an-aesthetic-management
#15
Sandipan Gupta, Debarati Chattopadhyay, Souradip Gupta, Akhilesh Agarwal, Gautam Guha
INTRODUCTION: A "giant" lipoma is defined as a tumor having dimensions greater than 10 cm. Giant lipomas are rare and giant breast lipomas are exceptionally uncommon. Only six cases have been described in world literature till date. Herein we describe a case of giant breast lipoma and discuss its surgical management. CASE REPORT: A 43-year-old lady presented with left sided unilateral gigantomastia. Clinical examination, radiology and histopathology diagnosed lipoma...
June 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28598827/expression-analysis-of-long-non-coding-atb-and-its-putative-target-in-breast-cancer
#16
Elahe Nikpayam, Mohammad Soudyab, Behnoosh Tasharrofi, Shaghayegh Sarrafzadeh, Mostafa Iranpour, Lobat Geranpayeh, Reza Mirfakhraie, Jalal Gharesouran, Soudeh Ghafouri-Fard
BACKGROUND: A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) has been recently shown to promote the invasion-metastasis cascade in various types of cancers via upregulation of some targets including ZEB1. OBJECTIVES: The aim of the present study was to elucidate the expression of lncRNA-ATB and ZEB in breast cancer patients. METHODS: The expression of these genes was evaluated by real-time reverse transcription polymerase chain reaction in tumor samples form 50 newly diagnosed breast cancer patients as well as their corresponding adjacent non-cancerous tissues (ANCTs)...
June 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28598826/the-evaluation-of-the-effect-of-metformin-on-breast-fibrocystic-disease
#17
A Talaei, A Moradi, F Rafiei
No abstract text is available yet for this article.
June 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28598825/retinoic-acid-related-orphan-receptor-alpha-rora-variants-and-risk-of-breast-cancer
#18
Mohammad Taheri, Mir Davood Omrani, Rezvan Noroozi, Shaghayegh Sarrafzadeh, Soudeh Ghafouri-Fard, Arezou Sayad
BACKGROUND: Breast cancer is the most common type of cancer and the second leading cause of cancer death in females. Despite numerous studies in this field, the etiology and clinical behavior of breast tumors have not been understood yet. Retinoid orphan nuclear receptor alpha (RORA) is a member of the orphan nuclear factor family involved in the regulation of lipid and steroid metabolism, immune response and circadian rhythms. Recent evidences support its role as a tumor suppressor gene...
June 2, 2017: Breast Disease
https://www.readbyqxmd.com/read/28269736/huge-lactating-adenoma-of-the-breast-case-report
#19
Islam A Elzahaby, Saleh Saleh, Islam H Metwally, Adel Fathi, Khaled Atallah
No abstract text is available yet for this article.
March 3, 2017: Breast Disease
https://www.readbyqxmd.com/read/29081405/the-enigma-of-granulomatous-mastitis-a-series
#20
Muhammad Umair Bashir, Alexius Ramcharan, Sarah Alothman, Sabine Beaugris Pa-C, Sarosh Ahmad Khan, Mohammed A Sbeih, Ryan Engdahl
Granulomatous mastitis is a chronic inflammatory breast disease with an enigmatic clinical presentation that can delay diagnosis and perpetuate ineffective treatments. We report our experience with the diagnosis and management of eighteen cases of granulomatous mastitis in the setting of an urban public hospital. The patients were identified after a retrospective review of pathology and surgery databases. Demographic, clinical, radiographic, histopathological data and treatment responses were reviewed. Out of a total of 18 patients, 8 patients were noted to be from Mexico...
February 20, 2017: Breast Disease
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