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Lung Cancer: Journal of the International Association for the Study of Lung Cancer

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https://www.readbyqxmd.com/read/30612819/osimertinib-induced-stevens-johnson-syndrome-in-a-patient-with-egfr-t790m-mutation-positive-non-small-cell-lung-cancer
#1
LETTER
Yi-Tsz Lin, Chia-Yu Chu
No abstract text is available yet for this article.
December 31, 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30591232/primary-pulmonary-collision-tumor-comprising-squamous-cell-carcinoma-and-mucosa-associated-lymphoid-tissue-lymphoma
#2
LETTER
Masahiro Yamasaki, Tomoyoshi Takenaka, Naoko Matsumoto, Hideki Asaoku, Masaya Taniwaki, Noboru Hattori
No abstract text is available yet for this article.
December 18, 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30553548/genetic-alterations-of-driver-genes-as-independent-prognostic-factors-for-disease-free-survival-in-patients-with-resected-non-small-cell-lung-cancer
#3
Akira Ono, Mitsuhiro Isaka, Masakuni Serizawa, Katsuhiro Omae, Hideaki Kojima, Kazuhisa Nakashima, Shota Omori, Kazushige Wakuda, Hirotsugu Kenmotsu, Tateaki Naito, Haruyasu Murakami, Kenichi Urakami, Takeshi Nagashima, Takashi Sugino, Masatoshi Kusuhara, Toshiaki Takahashi, Ken Yamaguchi, Yasuhisa Ohde
OBJECTIVES: This study assessed the associations between the molecular signatures and clinical information in non-small cell lung cancer (NSCLC) patients with postoperative disease-free survival (p-dfs) to identify novel prognostic factors, focusing on associations with driver gene alterations. MATERIALS AND METHODS: Between February 2014 and September 2015, 242 patients with NSCLC, including 192 patients with adenocarcinoma (Ad) and 50 patients with squamous cell carcinoma (Sq), underwent surgery and were enrolled in this study...
December 5, 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30459086/corrigendum-to-correlation-between-immune-related-adverse-events-and-efficacy-in-non-small-cell-lung-cancer-treated-with-nivolumab-lung-cancer-115-2018-71-74
#4
Koichi Sato, Hiroaki Akamatsu, Eriko Murakami, Seigo Sasaki, Kuninobu Kanai, Atsushi Hayata, Nahomi Tokudome, Keiichiro Akamatsu, Yasuhiro Koh, Hiroki Ueda, Masanori Nakanishi, Nobuyuki Yamamoto
No abstract text is available yet for this article.
November 17, 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30471812/radiotherapy-dose-escalation-in-locally-advanced-nsclc-the-limits-of-conventional-radiochemotherapy
#5
EDITORIAL
Matthias Guckenberger
No abstract text is available yet for this article.
November 15, 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30477806/potential-for-afatinib-as-an-optimal-treatment-for-advanced-non-small-cell-lung-carcinoma-in-patients-with-uncommon-egfr-mutations
#6
LETTER
Ichidai Tanaka, Masahiro Morise, Yuta Kodama, Akira Matsui, Naoya Ozawa, Sachiko Ozone, Daiki Goto, Ayako Miyazawa, Tetsunari Hase, Naozumi Hashimoto, Mitsuo Sato, Yoshinori Hasegawa
No abstract text is available yet for this article.
November 14, 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30545693/effects-of-primary-tumor-resection-on-the-survival-of-patients-with-stage-iv-extrathoracic-metastatic-non-small-cell-lung-cancer-a-population-based-study
#7
Zewen Sun, Xizhao Sui, Fan Yang, Jun Wang
BACKGROUND: Selected non-small cell lung cancer (NSCLC) patients with extrathoracic metastases might benefit from surgical intervention; however, the evidence is limited. We investigated the benefit of surgery in these patients regarding the extent of the metastatic disease. METHODS: Patients with extrathoracic metastatic NSCLC were identified in the US National Cancer Institute Surveillance, Epidemiology, and End Results database (2010-2015). Survival was compared before and after matching...
November 13, 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30449541/reply-to-the-comments-on-erlotinib-in-combination-with-bevacizumab-has-potential-benefit-in-non-small-cell-lung-cancer-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#8
LETTER
Binghao Zhao, Wenxiong Zhang
No abstract text is available yet for this article.
November 12, 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30448009/letter-in-reply-to-xu
#9
LETTER
Chong Hyun Suh, Kyung Won Kim, Mizuki Nishino
No abstract text is available yet for this article.
November 8, 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30642458/clinical-characteristics-and-medical-service-utilization-of-lung-cancer-in-china-2005-2014-overall-design-and-results-from-a-multicenter-retrospective-epidemiologic-survey
#10
Ju-Fang Shi, Le Wang, Ning Wu, Jun-Ling Li, Zhou-Guang Hui, Shang-Mei Liu, Bo-Yan Yang, Shu-Geng Gao, Jian-Song Ren, Hui-Yao Huang, Juan Zhu, Cheng-Cheng Liu, Jin-Hu Fan, Shi-Jun Zhao, Pu-Yuan Xing, Ye Zhang, Ning Li, Wen-Dong Lei, De-Bin Wang, Yun-Chao Huang, Xian-Zhen Liao, Xiao-Jing Xing, Ling-Bin Du, Li Yang, Yu-Qin Liu, Yong-Zhen Zhang, Kai Zhang, You-Lin Qiao, Jie He, Min Dai
OBJECTIVES: This study aimed to explore the clinical profile and its trajectory of lung cancer on clinicopathological characteristics and medical service utilization in China. METHODS: Patients diagnosed with primary lung cancer in tertiary hospitals during 2005-14 were selected from seven geographic regions of China. Data on clinical characteristics and medical service utilization was extracted from medical record, and the ten-year trends were explored. RESULTS: A total of 7184 patients were included, the mean age was 58...
February 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30642457/real-world-treatment-patterns-and-survival-of-patients-with-braf-v600-mutated-metastatic-non-small-cell-lung-cancer
#11
Leora Horn, Joshua Bauml, Patrick M Forde, Keith L Davis, Nathaniel J Myall, Medha Sasane, Anand Dalal, Ken Culver, Antoinette J Wozniak, Christina S Baik, Alex Mutebi, Pingkuan Zhang, Heather A Wakelee, Bruce E Johnson
INTRODUCTION: Clinical outcomes data on BRAF-mutated non-small cell lung cancer (NSCLC) patients treated in routine practice is limited. To address this gap, we described treatment patterns and survival in a cohort of these patients evaluated/treated at 7 US academic cancer centers during 2009-2016. METHODS: This was a retrospective chart review. Patients with BRAF V600-mutated metastatic NSCLC were selected. Current/previous participants in BRAF-related trials were excluded...
February 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30642456/patient-reported-outcomes-pros-in-lung-cancer-experiences-from-a-nationwide-feasibility-study
#12
Majken M Brønserud, Maria Iachina, Anders Green, Mogens Groenvold, Liv Dørflinger, Erik Jakobsen
OBJECTIVES: Our objectives were to examine the feasibility of a nationwide collection of patient-reported outcomes (PROs) in a lung cancer population as well as in various sub-populations, and to describe the characteristics of responders compared to non-responders. MATERIALS AND METHODS: All patients diagnosed with lung cancer in Denmark are registered in the Danish Lung Cancer Registry (DLCR). The 7,295 patients registered in DLCR from 1 October 2013 until 30 September 2015 who had received treatment were eligible...
February 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30642455/efficacy-of-first-line-treatment-with-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitor-egfr-tki-alone-or-in-combination-with-chemotherapy-for-advanced-non-small-cell-lung-cancer-nsclc-with-low-abundance-mutation
#13
Xiangtao Yan, Huijuan Wang, Peng Li, Guowei Zhang, Mina Zhang, Jinpo Yang, Xiaojuan Zhang, Xuanxuan Zheng, Zhiyong Ma
OBJECTIVE: The objective of this study was to investigate whether first-line treatment with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) in combination with chemotherapy improves the prognosis of patients with advanced non-small cell lung cancer (NSCLC) who harbour low-abundance EGFR mutations. PATIENTS AND METHODS: We retrospectively analysed the clinical data of 76 patients with advanced NSCLC who harboured low-abundance EGFR mutations...
February 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30642454/nut-and-peanut-butter-consumption-and-the-risk-of-lung-cancer-and-its-subtypes-a-prospective-cohort-study
#14
Lisette Nieuwenhuis, Piet A van den Brandt
OBJECTIVES: Nut consumption has been associated with reduced cancer-related mortality, but evidence for a relation between nut intake and lung cancer risk is limited. We investigated the association between total nut, tree nut, peanut, and peanut butter intake and the risk of lung cancer and its subtypes in the Netherlands Cohort Study. MATERIALS AND METHODS: In 1986, dietary and lifestyle habits of 120,852 participants, aged 55-69 years, were measured with a questionnaire...
February 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30642453/complete-tumor-response-of-a-locally-advanced-lung-large-cell-neuroendocrine-carcinoma-after-palliative-thoracic-radiotherapy-and-immunotherapy-with-nivolumab
#15
Charlotte Mauclet, Fabrice Duplaquet, Lionel Pirard, Benoît Rondelet, Michael Dupont, Claudia Pop-Stanciu, Thierry Vander Borght, Myriam Remmelink, Nicky D'Haene, Suzan Lambin, Marie Wanet, Vincent Remouchamps, Sebahat Ocak
Lung large-cell neuroendocrine carcinoma (L-LCNEC) is a rare subset of lung carcinoma associated with poor overall survival. Due to its rarity, little has been established about its optimal treatment in the advanced stage. We report the case of a 41-year-old woman diagnosed with an unresectable locally advanced L-LCNEC who presented an impressive tumor response to immunotherapy with nivolumab after non-curative thoracic radiotherapy. Salvage surgery was then performed, and pathologic analysis of the resected piece revealed the absence of residual viable tumor cells...
February 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30642452/prognostic-value-of-preoperative-exercise-capacity-in-patients-undergoing-thoracoscopic-lobectomy-for-non-small-cell-lung-cancer
#16
Kazumi Hamada, Masataka Irie, Yoshihisa Fujino, Masahiro Hyodo, Takeshi Hanagiri
OBJECTIVES: Whether or not the preoperative exercise capacity, as assessed by 6-min walk test, influences the survival of patients undergoing thoracoscopic lobectomy for lung cancer is unclear. We therefore investigated the prognostic value of the 6-min walk distance in this population. MATERIALS AND METHODS: This prospective cohort study was conducted between 2005 and 2013. We studied 224 consecutive subjects with stage I-II non-small cell lung cancer who underwent thoracoscopic lobectomy...
February 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30642451/static-lung-hyperinflation-is-an-independent-risk-factor-for-lung-cancer-in-patients-with-chronic-obstructive-pulmonary-disease
#17
Ester Zamarrón, Eva Prats, Elena Tejero, Paloma Pardo, Raúl Galera, Raquel Casitas, Elisabet Martínez-Cerón, Delia Romera, Ana Jaureguizar, Francisco García-Río
INTRODUCTION: Static hyperinflation, a hallmark characteristic of some patients with chronic obstructive pulmonary disease, is related to higher mortality and cardiovascular morbidity. However, information about its association with lung cancer is scarce. Our aim was to evaluate whether static hyperinflation is associated with future risk of lung cancer in COPD patients. METHODS: A cohort of 848 COPD patients recruited outside the hospital setting was monitored for an average period of 4...
February 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30642450/loss-of-t790m-mutation-is-associated-with-early-progression-to-osimertinib-in-chinese-patients-with-advanced-nsclc-who-are-harboring-egfr-t790m
#18
Sha Zhao, Xuefei Li, Chao Zhao, Tao Jiang, Yijun Jia, Jinpeng Shi, Yayi He, Jiayu Li, Fei Zhou, Guanghui Gao, Wei Li, Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Caicun Zhou
BACKGROUND: Osimertinib demonstrates superior efficacy in patients with non-small cell lung cancer (NSCLC) who acquired EGFR T790M mutation as resistant mechanism to upfront EGFR tyrosine kinase inhibitors (TKIs). Not all the T790M-positive tumors are homogeneously sensitive to osimertinib, however, and the duration of response often varies. Previous studies suggest that loss of T790 M at osimertinib resistance is correlated with shortened survival benefit of osimertinib. The aim of this study is to investigate the prevalence of T790 M loss after progression to osimertinib in Chinese patients with NSCLC harboring EGFR T790 M mutation and to compare their clinical outcomes and characteristics when stratified by T790 M mutational status at osimertinib resistance...
February 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30642449/co-expression-of-ido1-and-pd-l1-in-lung-squamous-cell-carcinoma-potential-targets-of-novel-combination-therapy
#19
Kazuki Takada, Kenichi Kohashi, Mototsugu Shimokawa, Akira Haro, Atsushi Osoegawa, Tetsuzo Tagawa, Takashi Seto, Yoshinao Oda, Yoshihiko Maehara
OBJECTIVES: Combination therapy with an inhibitor of indoleamine 2, 3-dioxygenase 1 (IDO1) and an agent targeting programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) is expected to be a novel and effective treatment option for various solid tumors including non-small cell lung cancer (NSCLC). Therefore, it is important to elucidate the clinical and pathological features of tumors with IDO1/PD-L1 co-expression and the association between IDO1/PD-L1 co-expression and efficacy of combination therapy in NSCLC patients...
February 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30642448/exploration-of-germline-variants-responsible-for-adverse-events-of-crizotinib-in-anaplastic-lymphoma-kinase-positive-non-small-cell-lung-cancer-by-target-gene-panel-sequencing
#20
Hidenori Mizugaki, Akinobu Hamada, Tatsuhiro Shibata, Fumie Hosoda, Hiromi Nakamura, Yusuke Okuma, Takehito Shukuya, Shigeki Umemura, Atsushi Horiike, Tomoya Fukui, Yoshihito Kogure, Haruko Daga, Yoshiko Urata, Kazuhiko Yamada, Sho Saeki, Yasuhito Fujisaka, Yukiko Nakamura, Mitsuo Sato, Tatsuya Yoshida, Takamasa Hotta, Satoshi Oizumi, Yasuhiro Fujiwara, Yuichiro Ohe, Yutaka Fujiwara
OBJECTIVES: Crizotinib is a standard treatment for advanced anaplastic lymphoma kinase (ALK)- or ROS1-fusion-gene-positive non-small cell lung cancer; however, serious adverse events (AEs), including elevated alanine aminotransferase (ALT)/aspartate aminotransferase (AST) and interstitial lung disease (ILD), develop occasionally. Here, we evaluated relationships between clinically significant crizotinib-associated AEs and germline variations. MATERIALS AND METHODS: DNA obtained from 75 patients allowed selection of 147 genes according to function, exon identification and sequencing, and determination of germline single nucleotide variants (SNVs)...
February 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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