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Lung Cancer: Journal of the International Association for the Study of Lung Cancer

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https://www.readbyqxmd.com/read/27894607/exosomes-in-lung-cancer-liquid-biopsies-two-sides-of-the-same-coin
#1
LETTER
Christian Rolfo, Marco Giallombardo, Pablo Reclusa, Rafael Sirera, Marc Peeters
No abstract text is available yet for this article.
November 18, 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27863911/crizotinib-for-ros1-patients-one-small-step-in-biomarker-testing-one-giant-leap-for-advanced-nsclc-patients
#2
EDITORIAL
Oscar Juan, Sanjay Popat
No abstract text is available yet for this article.
November 11, 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27769528/letter-to-the-editor
#3
Stella Regina Martins, Gustavo Faibischew Prado, Rafael Stelmach, Ubiratan Paula Santos
No abstract text is available yet for this article.
October 8, 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27720478/erratum-to-sunitinib-in-patients-with-advanced-thymic-malignancies-cohort-from-the-french-rythmic-network-lung-cancer-97-july-2016-99-104
#4
Jordi Remon, Nicolas Girard, Julien Mazieres, Eric Dansin, Eric Pichon, Laurent Greillier, Catherine Dubos, Colin R Lindsay, Benjamin Besse
No abstract text is available yet for this article.
October 6, 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27721121/withdrawn-tumor-b7-h3-cd276-expression-and-smoking-history-in-relation-to-lung-adenocarcinoma-prognosis
#5
Kentaro Inamura, Yusuke Yokouchi, Maki Kobayashi, Rie Sakakibara, Hironori Ninomiya, Sophia Subat, Hiroko Nagano, Kimie Nomura, Sakae Okumura, Tomoko Shibutani, Yuichi Ishikawa
The Publisher regrets that this article is an accidental duplication of an article that has already been published in The Journal of Lung Cancer - http://dx.doi.org/10.1016/j.lungcan.2016.11.013. Please see online announcement for additional details. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
October 1, 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27794416/biennial-lung-cancer-screening-in-canada-with-smoking-cessation-outcomes-and-cost-effectiveness
#6
John R Goffin, William M Flanagan, Anthony B Miller, Natalie R Fitzgerald, Saima Memon, Michael C Wolfson, William K Evans
BACKGROUND: Guidelines recommend low-dose CT (LDCT) screening to detect lung cancer among eligible at-risk individuals. We used the OncoSim model (formerly Cancer Risk Management Model) to compare outcomes and costs between annual and biennial LDCT screening. METHODS: OncoSim incorporates vital statistics, cancer registry data, health survey and utility data, cost, and other data, and simulates individual lives, aggregating outcomes over millions of individuals...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27794415/clinical-implications-of-sarcopenia-in-patients-undergoing-complete-resection-for-early-non-small-cell-lung-cancer
#7
Yuzo Suzuki, Tatsuro Okamoto, Takatoshi Fujishita, Masakazu Katsura, Takaki Akamine, Shinkichi Takamori, Yosuke Morodomi, Tetsuzo Tagawa, Fumihiro Shoji, Yoshihiko Maehara
OBJECTIVES: Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass and strength. We aimed to investigate sarcopenia in patients with stage I non-small cell lung cancer (NSCLC) who underwent complete resection, and the relationship of sarcopenia with clinicopathological factors. METHODS: All consecutive patients who underwent lung resection between January 2005 and December 2008 were enrolled in this retrospective study. Eligible patients were assigned to one of 2 groups according to the presence or absence of sarcopenia, as assessed by the sum of cross-sectional areas of skeletal muscles in the region of the third lumbar vertebra (L3) on preoperative computed tomography (CT)...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27794414/drug-interaction-between-erlotinib-and-phenytoin-for-brain-metastases-in-a-patient-with-nonsmall-cell-lung-cancer
#8
Masahiro Ohgami, Takayuki Kaburagi, Atsuhiko Kurosawa, Masato Homma
Erlotinib, a substrate drug metabolized by the CYP3A4 enzyme, is an epidermal growth factor receptor tyrosine kinase inhibitor used to treat nonsmall cell lung cancer (NSCLC). Concomitant use of erlotinib and the antiepileptic drug phenytoin, an inducer of CYP3A4, may result in a drug-drug interaction accompanied by changes in the blood concentrations of both drugs. We determined the blood concentration of each drug to confirm the interaction between phenytoin and erlotinib in a case of NSCLC with brain metastases...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27794413/prostaglandin-e-receptor-ep4-expression-survival-and-pattern-of-recurrence-in-locally-advanced-nsclc
#9
Neha Bhooshan, Paul N Staats, Amy M Fulton, Josephine L Feliciano, Martin J Edelman
BACKGROUND: Elevated COX-2 expression has been correlated with inferior outcome in NSCLC. COX-2 catalyzes the transformation of arachidonate to PGE2. We and others have demonstrated that PGE2 induces proliferation and metastatic spread and immunosuppression through the G protein-coupled EP4 receptor. We hypothesized that EP4 expression on malignant cells would correlate with outcome and patterns of relapse after treatment of LANSCLC stage IIIA (7th edition, N2+). METHODS: Tissue specimens from 41 pts treated for LANSC at UMGCC were obtained...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27794412/prediction-of-distant-recurrence-in-resected-stage-i-and-ii-lung-adenocarcinoma
#10
Beatrice Aramini, Christian Casali, Alessandro Stefani, Stefania Bettelli, Susanne Wagner, Zaina Sangale, Elisha Hughes, Jerry S Lanchbury, Antonino Maiorana, Uliano Morandi
OBJECTIVES: Optimal procedures for adjuvant treatment and post-surgical surveillance of resected non-small-cell lung cancer remain under discussion. Pathological features are the main determinant of follow-up therapy but have limited ability to identify patients at risk of recurrence. Increasingly, molecular markers are incorporated into clinical decision-making, including measures of tumor growth. The CCP score is a quantitative, molecular measure of proliferation derived from the RNA expression of 31 cell cycle genes and a component of the molecular prognostic score (mPS)...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27794411/outcome-in-patients-with-small-cell-lung-cancer-re-irradiated-for-brain-metastases-after-prior-prophylactic-cranial-irradiation
#11
Denise Bernhardt, Farastuk Bozorgmehr, Sebastian Adeberg, Nils Opfermann, Damian von Eiff, Juliane Rieber, Jutta Kappes, Robert Foerster, Laila König, Michael Thomas, Jürgen Debus, Martin Steins, Stefan Rieken
OBJECTIVES: Patients with brain metastases from small-cell lung cancer (SCLC) who underwent prior prophylactic cranial irradiation (PCI) are often treated with a second course of whole brain radiation therapy (Re-WBRT) or stereotactic radiosurgery (SRS) for purposes of palliation in symptomatic patients, hope for increased life expectancy or even as an alternative to untolerated steroids. Up to date there is only limited data available regarding the effect of this treatment. This study examines outcomes in patients in a single institution who underwent cerebral re-irradiation after prior PCI...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27794410/development-of-symptomatic-brain-metastases-after-chemoradiotherapy-for-stage-iii-non-small-cell-lung-cancer-does-the-type-of-chemotherapy-regimen-matter
#12
Lizza E L Hendriks, Anita J W M Brouns, Mohammad Amini, Wilma Uyterlinde, Robin Wijsman, Jan Bussink, Bonne Biesma, S Bing Oei, Jos A Stigt, Gerben P Bootsma, José S A Belderbos, Dirk K M De Ruysscher, Michel M Van den Heuvel, Anne-Marie C Dingemans
OBJECTIVES: Symptomatic brain metastases (BM) occur frequently after chemoradiotherapy (CRT) for stage III NSCLC. Aim of the current study was to determine whether the specific chemotherapy used in a CRT regimen influences BM development. MATERIALS AND METHODS: Retrospective multicenter study including all consecutive stage III NSCLC who completed CRT. Primary endpoints: symptomatic BM development, whether this was the only site of first relapse. Differences between regimens were assessed with a logistic regression model including known BM risk factors and the specific chemotherapy: concurrent versus sequential (cCRT/sCRT), within cCRT: daily low dose cisplatin (LDC)-cyclic dose polychemotherapy; LDC-(non-)taxane cyclic dose; LDC-polychemotherapy subgroups of ≥50 patients...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27794409/high-met-status-in-non-small-cell-lung-tumors-correlates-with-receptor-phosphorylation-but-not-with-the-serum-level-of-soluble-form
#13
Marie-Christine Copin, Marie Lesaffre, Mélanie Berbon, Louis Doublet, Catherine Leroy, Emmanuelle Tresch, Henri Porte, Jérôme Vicogne, Alexis B Cortot, Eric Dansin, David Tulasne
OBJECTIVES: The receptor tyrosine kinase MET is essential to embryonic development and organ regeneration. Its deregulation is associated with tumorigenesis. While MET gene amplification and mutations leading to MET self-activation concern only a few patients, a high MET level has been found in about half of the non-small cell lung cancers (NSCLCs) tested. How this affects MET activation in tumors is unclear. Also uncertain is the prognostic value, in cancer, of a phenomenon well described in cell models: MET shedding, i...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27794408/imaging-in-pleural-mesothelioma-a-review-of-the-13th-international-conference-of-the-international-mesothelioma-interest-group
#14
REVIEW
Samuel G Armato, Kevin G Blyth, Jane J Keating, Sharyn Katz, Selina Tsim, Johan Coolen, Eyjolfur Gudmundsson, Isabelle Opitz, Anna K Nowak
Imaging plays an important role in the detection, diagnosis, staging, response assessment, and surveillance of malignant pleural mesothelioma. The etiology, biology, and growth pattern of mesothelioma present unique challenges for each modality used to capture various aspects of this disease. Clinical implementation of imaging techniques and information derived from images continue to evolve based on active research in this field worldwide. This paper summarizes the imaging-based research presented orally at the 2016 International Conference of the International Mesothelioma Interest Group (iMig) in Birmingham, United Kingdom, held May 1-4, 2016...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27794407/diagnostic-algorithm-for-detection-of-targetable-driver-mutations-in-lung-adenocarcinomas-comprehensive-analyses-of-205-cases-with-immunohistochemistry-real-time-pcr-and-fluorescence-in-situ-hybridization-methods
#15
Hua-Lin Kao, Yi-Chen Yeh, Chin-Hsuan Lin, Wei-Fang Hsu, Wen-Yu Hsieh, Hsiang-Ling Ho, Teh-Ying Chou
OBJECTIVES: Analysis of the targetable driver mutations is now recommended in all patients with advanced lung adenocarcinoma. Molecular-based methods are usually adopted, however, along with the implementation of highly sensitive and/or mutation-specific antibodies, immunohistochemistry (IHC) has been considered an alternative method for identifying driver mutations in lung adenocarcinomas. MATERIALS AND METHODS: A total of 205 lung adenocarcinomas were examined for EGFR mutations and ALK and ROS1 rearrangements using real-time PCR, fluorescence in situ hybridization (FISH) and IHC in parallel...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27794406/the-impact-of-lung-cancer-surgery-on-quality-of-life-trajectories-in-patients-and-family-caregivers
#16
Jae Y Kim, Virginia Sun, Dan J Raz, Anna Cathy Williams, Rebecca Fujinami, Karen Reckamp, Marianna Koczywas, Mihaela Cristea, Arti Hurria, Betty Ferrell
OBJECTIVES: Family caregivers (FCGs) play an important role in the quality of life (QOL) of lung cancer patients. FCGs experience significant psychological distress related to their caregiving role, but there is relatively little data about FCG QOL after cancer surgery. We sought to describe QOL trajectories for patients and their FCGs after lung cancer surgery. METHODS: This is a secondary analysis of a larger, prospective QOL study, testing the effectiveness of an interdisciplinary palliative care intervention for lung cancer patients and FCGs in a single institution...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27794405/robot-assisted-surgery-for-lung-cancer-state-of-the-art-and-perspectives
#17
REVIEW
Giulia Veronesi, Pierluigi Novellis, Emanuele Voulaz, Marco Alloisio
The robotic surgical system is the result of a long process of development aimed at producing a natural extension of the surgeon's eyes and hands via the intermediation of a computer. In this way, the ease of movement obtained with open surgery is summated with the advantages of the minimally invasive technique. Since 2000, when the first robotic system for surgery was introduced, robot-assisted thoracic surgery (RATS) has been adopted by an increasing number of centres around the world, and today is used in ∼10% of lobectomies in the US...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27794404/limited-thymectomy-as-a-potential-alternative-treatment-option-for-early-stage-thymoma-a-multi-institutional-propensity-matched-study
#18
Kyoung Shik Narm, Chang Young Lee, Young Woo Do, Hee Suk Jung, Go Eun Byun, Jin Gu Lee, Dae Joon Kim, Yoohwa Hwang, In Kyu Park, Chang Hyun Kang, Young Tae Kim, Jong Ho Cho, Yong Soo Choi, Jhingook Kim, Yong Mog Shim, Su Kyung Hwang, Yong-Hee Kim, Dong Kwan Kim, Seung-Il Park, Kyung Young Chung
OBJECTIVES: For early-stage thymoma, complete thymectomy has classically been regarded as the standard treatment protocol. However, several studies have shown that limited thymectomy may be an alternative treatment option for thymoma. This study compared perioperative outcomes, survival, and recurrence rates between patients undergoing limited thymectomy and complete thymectomy. MATERIALS AND METHODS: Between January 2000 and December 2013, a total of 762 patients underwent thymectomy for stage I or II thymomas at four institutions participating in the Korean Association for Research on the Thymus...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27794403/clinicopathologic-characteristics-genetic-variability-and-therapeutic-options-of-ret-rearrangements-patients-in-lung-adenocarcinoma
#19
Zhengbo Song, Xinmin Yu, Yiping Zhang
BACKGROUND: RET fusion gene is identified as a novel oncogene in a subset of non-small cell lung cancer (NSCLC). However, few data are available about the prevalence, clinicopathologic characteristics, genetic variability and therapeutic options in RET-positive lung adenocarcinoma patients. PATIENTS AND METHODS: For 615 patients with lung adenocarcinoma, RET status was detected by reverse transcription-polymerase chain reaction (RT-PCR). Next-generation sequencing (NGS) and FISH were performed in positive cases...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27794402/the-prevalence-of-expression-of-mage-a3-and-prame-tumor-antigens-in-east-and-south-east-asian-non-small-cell-lung-cancer-patients
#20
Sumitra Thongprasert, Pan-Chyr Yang, Jung Shin Lee, Ross Soo, Olivier Gruselle, Aung Myo, Jamila Louahed, Frédéric F Lehmann, Vincent G Brichard, Thierry Coche
INTRODUCTION: Treatment of non-small cell lung cancer (NSCLC) is an important and often unmet medical need regardless of the disease stage at the time of first diagnosis. Antigen-specific immunotherapy may be a feasible therapeutic option if tumor associated antigens (TAAs) that can be targeted by the patient's immune system are identified. The study objective (NCT01837511) was to investigate the expression rates of MAGE-A3 and PRAME in tumors from East Asian NSCLC patients, and the associations between TAA expression and clinico-pathologic patient characteristics...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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