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Brain, Behavior, and Immunity

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https://www.readbyqxmd.com/read/28532818/tdp-43-upregulation-mediated-by-the-nlrp3-inflammasome-induces-cognitive-impairment-in-2-2-4-4-tetrabromodiphenyl-ether-bde-47-treated-mice
#1
Juan Zhuang, Xin Wen, Yan-Qiu Zhang, Qun Shan, Zi-Feng Zhang, Gui-Hong Zheng, Shao-Hua Fan, Meng-Qiu Li, Dong-Mei Wu, Bin Hu, Jun Lu, Yuan-Lin Zheng
It is now commonly known that exposure to polybrominated diphenyl ethers (PBDEs) may cause neurotoxicity and cognitive deficits in children as well as adults, but the underlying mechanisms are still not clear. In the present study, we aimed to elucidate the potential underlying mechanism of 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47)-induced neurotoxicity and cognitive impairment. Our results showed that BDE-47-treated mice exhibited impaired cognition and robust upregulation of nuclear TDP-43 in the hippocampus...
May 19, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28529072/rescue-of-il-1%C3%AE-induced-reduction-of-human-neurogenesis-by-omega-3-fatty-acids-and-antidepressants
#2
Alessandra Borsini, Silvia Alboni, Mark A Horowitz, Luis M Tojo, Giuseppe Cannazza, Kuan-Pin Su, Carmine M Pariante, Patricia A Zunszain
Both increased inflammation and reduced neurogenesis have been associated with the pathophysiology of major depression. We have previously described how interleukin-1 (IL-1) β,a pro-inflammatory cytokine increased in depressed patients, decreases neurogenesis in human hippocampal progenitor cells. Here, using the same human in vitro model, we show how omega-3 (ω-3) polyunsaturated fatty acids and conventional antidepressants reverse this reduction in neurogenesis, while differentially affecting the kynurenine pathway...
May 18, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28529071/exogenous-fgf2-reverses-depressive-like-behaviors-and-restores-the-suppressed-fgf2-erk1-2-signaling-and-the-impaired-hippocampal-neurogenesis-induced-by-neuroinflammation
#3
Ming-Ming Tang, Wen-Juan Lin, Jun-Tao Zhang, Ya-Wei Zhao, Ying-Cong Li
Our previous work demonstrated that neuroinflammation evoked by triple repeated central LPS challenges inhibited adult hippocampal neurogenesis that were correlated with the depressive-like behavioral symptoms induced by neuroinflammation. These findings suggest that hippocampal neurogenesis might be one of biological mechanisms underlying depression induced by neuroinflammation and targeting neurogenesis might lead to new therapeutic strategies for the treatment of depression. In this study, we manipulated adult hippocampal neurogenesis using fibroblast growth factor 2 (FGF2), one crucial molecule modulating cell proliferation and survival in central nervous system, and investigate the involvement and the potential therapeutic effects of FGF2 on neuroinflammation-induced depression...
May 18, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28526436/intracranial-il-17a-overexpression-decreases-cerebral-amyloid-angiopathy-by-upregulation-of-abca1-in-an-animal-model-of-alzheimer-s-disease
#4
Junling Yang, Jinghong Kou, Robert Lalonde, Ken-Ichiro Fukuchi
Neuroinflammation is a pervasive feature of Alzheimer's disease (AD) and characterized by activated microglia, increased proinflammatory cytokines and/or infiltrating immune cells. T helper 17 (Th17) cells are found in AD brain parenchyma and interleukin-17A (IL-17A) is identified around deposits of aggregated amyloid β protein (Aβ). However, the role of IL-17A in AD pathogenesis remains elusive. We overexpressed IL-17A in an AD mouse model via recombinant adeno-associated virus serotype 5 (rAAV5)-mediated intracranial gene delivery...
May 17, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28526435/the-bidirectional-gut-brain-microbiota-axis-as-a-potential-nexus-between-traumatic-brain-injury-inflammation-and-disease
#5
Mark H Sundman, Nan-Kuei Chen, Vignesh Subbian, Ying-Hui Chou
As head injuries and their sequelae have become an increasingly salient matter of public health, experts in the field have made great progress elucidating the biological processes occurring within the brain at the moment of injury and throughout the recovery thereafter. Given the extraordinary rate at which our collective knowledge of neurotrauma has grown, new insights may be revealed by examining the existing literature across disciplines with a new perspective. This article will aim to expand the scope of this rapidly evolving field of research beyond the confines of the central nervous system (CNS)...
May 16, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28512033/bifidobacterium-cect-7765-modulates-early-stress-induced-immune-neuroendocrine-and-behavioral-alterations-in-mice
#6
A Moya-Pérez, A Perez-Villalba, A Benítez-Páez, I Campillo, Y Sanz
Emerging evidence suggests that there is a window of opportunity within the early developmental period, when microbiota-based interventions could play a major role in modulating the gut-brain axis and, thereby, in preventing mood disorders. This study aims at evaluating the effects and mode of action of Bifidobacterium pseudocatenulatum CECT 7765 in a murine model of chronic stress induced by maternal separation (MS). C57Bl/6J male breast-fed pups were divided into four groups, which were subjected or not to MS and supplemented with placebo or B...
May 13, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28506692/sex-differences-in-microglial-appetites-during-development-inferences-and-implications
#7
Staci D Bilbo
No abstract text is available yet for this article.
May 12, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28502880/maternal-care-modulates-the-febrile-response-to-lipopolysaccharide-through-differences-in-glucocorticoid-receptor-sensitivity-in-the-rat
#8
Carine Parent, Huy-Binh Nguyen, Xianglan Wen, Josie Diorio, Michael J Meaney, Tie Yuan Zhang
Early life adversity increases the risk for later infection. The febrile response is a potent mechanism to combat infection. We found that variations in maternal care influence the febrile response to 50 µg/kg lipopolysaccharide (LPS) challenge in adult male rats. Offspring from low-licking/grooming (LG) mothers had an increased febrile response compared to offspring from high-LG mothers challenged with LPS. Low-LG offspring had reduced plasma IL-6 at one and two hours post challenge compared to high-LG offspring...
May 10, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28502879/genetic-deletion-of-p-glycoprotein-alters-stress-responsivity-and-increases-depression-like-behavior-social-withdrawal-and-microglial-activation-in-the-hippocampus-of-female-mice
#9
Natalia I Brzozowska, Kristie L Smith, Cilla Zhou, Peter M Waters, Ligia Menezes Cavalcante, Sarah V Abelev, Michael Kuligowski, David J Clarke, Stephanie M Todd, Jonathon C Arnold
P-glycoprotein (P-gp) is an ABC transporter expressed at the blood brain barrier and regulates the brain uptake of various xenobiotics and endogenous mediators including glucocorticoid hormones which are critically important to the stress response. Moreover, P-gp is expressed on microglia, the brain's immune cells, which are activated by stressors and have an emerging role in psychiatric disorders. We therefore hypothesised that germline P-gp deletion in mice might alter the behavioral and microglial response to stressors...
May 10, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28495611/hiv-1-tat-protein-enhances-sensitization-to-methamphetamine-by-affecting-dopaminergic-function
#10
James P Kesby, Julia A Najera, Benedetto Romoli, Yiding Fang, Liana Basova, Amanda Birmingham, Maria Cecilia G Marcondes, Davide Dulcis, Svetlana Semenova
Methamphetamine abuse is common among humans with immunodeficiency virus (HIV). The HIV-1 regulatory protein TAT induces dysfunction of mesolimbic dopaminergic systems which may result in impaired reward processes and contribute to methamphetamine abuse. These studies investigated the impact of TAT expression on methamphetamine-induced locomotor sensitization, underlying changes in dopamine function and adenosine receptors in mesolimbic brain areas and neuroinflammation (microgliosis). Transgenic mice with doxycycline-induced TAT protein expression in the brain were tested for locomotor activity in response to repeated methamphetamine injections and methamphetamine challenge after a 7-day abstinence period...
May 8, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28495610/-allergic-mood-depressive-and-anxiety-symptoms-in-patients-with-seasonal-allergic-rhinitis-sar-and-their-association-to-inflammatory-endocrine-and-allergic-markers
#11
Katharina Trikojat, Hella Luksch, Angela Rösen-Wolff, Franziska Plessow, Jochen Schmitt, Angelika Buske-Kirschbaum
A growing number of studies show an association between seasonal allergic rhinitis (SAR) with depression and anxiety. The underlying mechanisms of a link between SAR and affect, however, are still unclear. The objective of the present study was to investigate depressive symptoms and anxiety in SAR patients and their association to inflammatory and endocrine parameters. SAR patients (n=41) and non-allergic, healthy controls (n=42) were assessed during (pollen season) and out of symptomatic periods (non-pollen season)...
May 8, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28487203/mmps-timps-imbalances-in-the-peripheral-blood-and-cerebrospinal-fluid-are-associated-with-the-pathogenesis-of-hiv-1-associated-neurocognitive-disorders-a-pilot-study
#12
Yanyan Xing, Nicole Shepherd, Jie Lan, Wei Li, Sushmita Rane, Samir K Gupta, Shanxiang Zhang, Jun Dong, Qigui Yu
HIV-1-associated neurocognitive disorders (HAND) continue to be a major concern in the infected population, despite the widespread use of combined antiretroviral therapy (cART). Growing evidence suggests that an imbalance between matrix metalloproteinases (MMPs) and endogenous tissue inhibitors of MMPs (TIMPs) contributes to the pathogenesis of HAND. In our present study, we examined protein levels and enzymatic activities of MMPs and TIMPs in both plasma and cerebrospinal fluid (CSF) samples from HIV-1 patients with or without HAND and HIV-1-negative controls...
May 6, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28487202/thalamic-mast-cell-activity-is-associated-with-sign-tracking-behavior-in-rats
#13
Christopher J Fitzpatrick, Jonathan D Morrow
Mast cells are resident immune cells in the thalamus that can degranulate and release hundreds of signaling molecules (i.e., monoamines, growth factors, and cytokines) both basally and in response to environmental stimuli. Interestingly, mast cell numbers in the brain show immense individual variation in both rodents and humans. We used a Pavlovian conditioned approach (PCA) procedure to examine whether mast cells are associated with individual variation in the attribution of incentive-motivational value to reward-related cues...
May 6, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28483660/markers-of-neuroinflammation-and-neuronal-injury-in-bipolar-disorder-relation-to-prospective-clinical-outcomes
#14
Anniella Isgren, Carl Sellgren, Carl-Johan Ekman, Jessica Holmén-Larsson, Kaj Blennow, Henrik Zetterberg, Joel Jakobsson, Mikael Landén
BACKGROUND: Neuroimmune mechanisms have been linked to the pathophysiology of bipolar disorder based on studies of biomarkers in plasma, cerebrospinal fluid (CSF), and postmortem brain tissue. There are, however, no longitudinal studies investigating if CSF markers of neuroinflammation and neuronal injury predict clinical outcomes in patients with bipolar disorder. We have in previous studies found higher CSF concentrations of interleukin-8 (IL-8), monocyte chemoattractant protein 1 (MCP-1/CCL-2), chitinase-3-like protein 1 (CHI3L1/YKL-40), and neurofilament light chain (NF-L) in euthymic patients with bipolar disorder compared with controls...
May 5, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28483659/the-long-non-coding-rna-neat1-is-an-important-mediator-of-the-therapeutic-effect-of-bexarotene-on-traumatic-brain-injury-in-mice
#15
Jianjun Zhong, Li Jiang, Zhijian Huang, Hongrong Zhang, Chongjie Cheng, Han Liu, Junchi He, Jingchuan Wu, Rami Darwazeh, Yue Wu, Xiaochuan Sun
OBJECTIVE: Bexarotene treatments exert neuroprotective effects on mice following traumatic brain injury (TBI). The present study aims to investigate the potential roles of the long noncoding RNA Neat1 in the neuroprotective effects of bexarotene. MATERIALS AND METHODS: Adult male C57BL/6J mice (n=80) and newborn mice (within 24 h after birth) (n=20) were used to generate a "controlled cortical impact" (CCI) model and harvest primary cortex neurons, respectively...
May 5, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28476558/low-expression-of-complement-inhibitory-protein-cd59-contributes-to-humoral-autoimmunity-against-astrocytes
#16
Zhen Wang, Wen Guo, Yuanchu Liu, Ye Gong, Xiaoli Ding, Kaibin Shi, Rodolfo Thome, Guang-Xian Zhang, Fu-Dong Shi, Yaping Yan
Neuromyelitis optica spectrum disorder is primarily an anti-aquaporin 4 autoantibody-mediated, central nervous system-restricted channelopathy. Patients frequently develop central nervous system-restricted lesions even though autoantigen aquaporin 4 in neuromyelitis optica spectrum disorder is broadly distributed in the central nervous system and peripheral organs. The cause of such tissue-specific immune response remains largely unknown. We confirmed here that CD59, an inhibitory regulator of the complement membrane attack complex, is expressed and co-localized with aquaporin 4 in peripheral organs but is only minimally expressed in astrocytes in the central nervous system...
May 2, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28457811/methylene-blue-attenuates-neuroinflammation-after-subarachnoid-hemorrhage-in-rats-through-the-akt-gsk-3%C3%AE-mef2d-signaling-pathway
#17
Hangzhe Xu, Jianru Li, Zhijiang Wang, Majing Feng, Yongfeng Shen, Shenglong Cao, Tao Li, Yucong Peng, Linfeng Fan, Jingyin Chen, Chi Gu, Feng Yan, Lin Wang, Gao Chen
Subarachnoid hemorrhage (SAH) is a serious medical problem with few effective pharmacotherapies available, and neuroinflammation has been identified as an important pathological process in early brain injury (EBI) after SAH. Methylene blue (MB) is an older drug that has been recently proven to exert extraordinary neuroprotective effects in several brain insults. However, no study has reported the beneficial effects of MB in SAH. In the current investigation, we studied the neuroprotective effects of MB in EBI after SAH and focused on its anti-inflammatory role...
April 27, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28457810/chronic-stress-suppresses-anti-tumor-tcd8-responses-and-tumor-regression-following-cancer-immunotherapy-in-a-mouse-model-of-melanoma
#18
Annette Sommershof, Lisa Scheuermann, Julia Koerner, Marcus Groettrup
Animal tumor models and human cancer studies have provided convergent evidence that chronic psychological stress plays a decisive role in modulating anti-tumor T cell immunity. However, whether chronic stress also affects anti-cancer vaccine strategies that rely on the induction of functional tumor-specific TCD8+ cells has not been investigated yet. In this study we provide direct evidence that chronic stress suppresses the therapeutic efficacy of a biodegradable poly(d,l-lactide-co-glycolide) microsphere (PLGA-MS) based cancer vaccine in a murine melanoma model...
April 27, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28457809/circulating-inflammatory-biomarkers-in-relation-to-brain-structural-measurements-in-a-non-demented-elderly-population
#19
Yian Gu, Robert Vorburger, Nikolaos Scarmeas, José A Luchsinger, Jennifer J Manly, Nicole Schupf, Richard Mayeux, Adam M Brickman
The aim of this investigation was to determine whether circulating inflammatory biomarkers c-reactive protein (CRP), interleukin-6 (IL6), and alpha 1-antichymotrypsin (ACT) were related to structural brain measures assessed by magnetic resonance imaging (MRI). High-resolution structural MRI was collected on 680 non-demented elderly (mean age 80.1years) participants of a community-based, multiethnic cohort. Approximately three quarters of these participants also had peripheral inflammatory biomarkers (CRP, IL6, and ACT) measured using ELISA...
April 27, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28455264/using-functional-and-molecular-mri-techniques-to-detect-neuroinflammation-and-neuroprotection-after-traumatic-brain-injury
#20
Wenzhu Wang, Hong Zhang, Doon-Hoon Lee, Jintao Yu, Tian Cheng, Michael Hong, Shanshan Jiang, Heng Fan, Xi Huang, Jinyuan Zhou, Jian Wang
This study was designed to investigate whether functional and molecular MRI techniques are sensitive biomarkers for assessment of neuroinflammation and drug efficacy after traumatic brain injury (TBI) in rats. We subjected rats to a controlled cortical impact model and used behavioral tests, histology, and immunofluorescence to assess whether flavonoid pinocembrin provides cerebral protection and improves functional recovery. Most importantly, we used multiple noninvasive structural, functional, and molecular MRI techniques to examine whether the pinocembrin-related neuroprotection and attenuation of neuroinflammation can be detected in vivo...
April 25, 2017: Brain, Behavior, and Immunity
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