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Immunopharmacology and Immunotoxicology

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https://www.readbyqxmd.com/read/30111221/enhancement-of-anti-tumor-effect-of-plasmid-dna-carrying-muc1-by-the-adjuvanticity-of-flt3l-in-mouse-model
#1
Fu-Sheng Gao, Yu-Tao Zhan, Xu-Dong Wang, Chuan Zhang
AIM: DNA vaccines have emerged as a promising strategy for cancer immunotherapy; however, their immunogenicity is weak. Fms-like tyrosine kinase 3-ligand (Flt3L) has been exploited for its ability to increase the proliferation of dendritic cells (DCs). The aim of the present study was to investigate whether co-administration of an adjuvant plasmid expressing mouse Flt3L and a DNA vaccine of the Mucin 1 (MUC1) antigen enhances immune responses. METHODS: The recombinant plasmids pVAX1-MUC1 and pVAX1-Flt3L were constructed and injected into mice intramuscularly (i...
August 15, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/30111205/ketamine-delays-progression-of-oxidative-and-damaged-cataract-through-regulating-hmgb-1-nf-%C3%AE%C2%BAb-in-lens-epithelial-cells
#2
Dong Xu, Hongying Zhu, Qingdong Fu, Songxiao Xu, Wen Sun, Guoxiao Chen, Xiaoli Lv
OBJECTIVE: Lens epithelial cell (LEC) membrane damage is one of the pathogenesis of cataract. High mobility group box-1 (HMGB-1) and nuclear factor-κB (NF-κB) play vital roles in a variety of diseases, such as inflammation. Ketamine has numerous pharmacological effects that can inhibit inflammation. However, its role in cataract rats LECs has not yet been elucidated. MATERIALS AND METHODS: LECs were isolated from SD rats and cultured in vitro. The cells were randomly divided into three groups, including the control group, cataract model group induced by H2 O2 , and ketamine group treated by 10 mM ketamine under H2 O2 environment...
August 15, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/30111198/curcumin-as-a-therapeutic-agent-for-blocking-nf-%C3%AE%C2%BAb-activation-in-ulcerative-colitis
#3
Yiqing Wang, Qichun Tang, Peibei Duan, Lihua Yang
Ulcerative colitis (UC) is a chronic, relapsing, remitting, and inflammatory disorder that afflicts millions of people around the world. It carries a substantial economic burden, reducing the quality of life, ability to work, and increasing disability. Conventional medical treatment of UC includes the use of aminosalicylates, corticosteroids, and immunosuppressive drugs. However, these medicines are not always effective due to some serious side effects. Nuclear factor-kappa B (NF-κB) is a key factor in the inflammatory setting and strongly affects the course of mucosal inflammation in UC...
August 15, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/30088954/potential-risk-factors-related-to-the-development-of-gastric-polyps
#4
Wenjun Cao, Guoqiang Hou, Xin Zhang, Hongxia San, Jianzhong Zheng
OBJECTIVE: Gastric polyps (GPs) are masses of cells that form on the lining inside stomach. The diagnosis and treatment of GPs are vital, since some cases may cause malignant. Endoscopic techniques have led to earlier detection of GPs, the incidence of GPs are projected to continue rising. The treatment of GPs and investigation are specific to the possible presentation, pathology, and malignant. This paper is to investigate risk factors related to GPs patients in China. MATERIALS AND METHODS: Total of 2048 patients who underwent gastrointestinal endoscopy from January 2014 to December 2014 were studied...
August 8, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/30052483/the-beneficial-effects-of-18%C3%AE-glycyrrhetinic-acid-on-the-experimental-autoimmune-encephalomyelitis-eae-in-c57bl-6-mouse-model
#5
Suat Kamisli, Osman Ciftci, Asli Taslidere, Nese Basak Turkmen, Cemal Ozcan
AIM: The aim of this study was to investigate the beneficial effects of 18β-glycyrrhetinic acid (GA) on the experimental allergic encephalomyelitis (EAE) in C57BL/6 mice. GA is a natural substance found in the root of licorice and is used in traditional Chinese medicine. It has many pharmacological activities such as antioxidant, anti-inflammatory, and anti-cancer effects. MATERIALS AND METHODS: A total of 40 C57BL/6 mice were divided equally into four groups: (1) Control, (2) EAE, (3) GA and (4) GA + EAE...
July 27, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/30040512/reflections-on-treatment-of-ibd-in-children-and-adolescents
#6
Geneviève Veereman, Bruno Hauser, Elisabeth De Greef, Thierry Devreker, Koen Huysentruyt, Roel Lemmens, Yvan Vandenplas
Major pharmaceutical advancements in the field of inflammatory bowel diseases benefit to children and adolescents affected with this progressive chronic condition. Scientific organisations such as ESPGHAN and ECCO actively publish guidelines related to the many aspects of care from these patients. Clinical studies and long-term prospective registries in the appropriate age groups are crucial to support an evidence based strategy.
July 24, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/30040510/a-new-sight-for-paraquat-poisoning-from-immunology
#7
Qiang Wu, Qinliang Xu, Xiangdong Jian, Huaxue Wang, Xiandi He, Beijun Gao, Ke Wang, Baotian Kan
Paraquat (methyl viologen, PQ) is highly toxic to humans. Pulmonary fibrosis is the most common cause of death after PQ poisoning. However, no effective therapy is available. The current treatment dilemma and pathology suggest that we should reconsider how to treat the poisoning using other methods, such as immunization. Some clues indicate that immune mechanisms may play important roles in the pathology of PQ poisoning. We implemented a simple experiment to test the hypothesis that activated innate immunity was involved in acute lung injury induced by PQ...
July 24, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/30035658/dual-role-of-acid-sensing-ion-channels-3-in-rheumatoid-arthritis-destruction-or-protection
#8
Gui-Mei Yu, Di Liu, Na Yuan, Bao-Hua Liu
Acid-sensing ion channels (ASIC) are voltage-independent cationic channels that open in response to decrease in extracellular pH. Amongst different subtypes, ASIC3 has received much attention in joint inflammatory conditions including rheumatoid arthritis. There have been a number of studies showing that there is an increase in expression of ASIC3 on nerve afferents supplying joints in response to inflammatory stimulus. Accordingly, a number of selective as well as nonselective ASIC3 inhibitors have shown potential in attenuating pain and inflammation in animal models of rheumatoid arthritis...
July 23, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/30003821/the-protective-effect-of-berberine-against-lipopolysaccharide-induced-abortion-by-modulation-of-inflammatory-immune-responses
#9
Maryam Mahdavi Siuki, Nafiseh Fazel Nasab, Elham Barati, Maryam Nezafat Firizi, Tahereh Jalilvand, Hasan Namdar Ahmadabad
OBJECTIVE: Berberine is an isoquinoline derivative alkaloid with anti-inflammatory activity. In this study, we investigated the protective effects of berberine in prevention of LPS-induced abortion. MATERIALS AND METHODS: On the gestation day (GD) 9.5, the pregnant mice were injected with low, medium, and high doses of berberine or with PBS. After 4 h, berberine or PBS-pretreated mice were injected with LPS. On GD 11.5, blood samples and uterine tissues were collected from treated mice and percentage of abortion and serum levels of NO, TNF-α, IL-10, and IL12p70 were measured by macroscopic examination and sandwich ELISA, respectively...
July 13, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/30003817/the-epigenetic-modification-during-the-induction-of-foxp3-with-sodium-butyrate
#10
Tengli Cao, Xiuxiu Zhang, Dingding Chen, Peiyan Zhang, Qing Li, Abbas Muhammad
CONTEXT: CD4 + CD25+ regulatory T (Treg) lymphocytes are critical for immune homeostasis. Foxp3 (Forkhead Box protein P3) is always considered as a marker of function and identities determination of Treg cells because of special occurring in Treg cell. People who lack Treg cells or have a low expression of Foxp3 gene will suffer fatal autoimmunity. Scientists are trying to use Treg cells as a treatment for autoimmune disease, such as systemic lupus erythematosus. OBJECTIVE: Our objective was to induce Foxp3 + CD4+ T cells from naïve CD4 + T cells isolated from C57 mice spleen in vitro using stimuli that include the short chain fatty acid sodium butyrate...
July 13, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29957081/anticancer-agent-abt-737-possesses-anti-atopic-dermatitis-activity-via-blockade-of-caspase-1-in-atopic-dermatitis-in-vitro-and-in-vivo-models
#11
Hyun-Ja Jeong, Ka-Jung Ryu, Hyung-Min Kim
OBJECTIVE: Previous studies reported that depletion of Bcl-2 has a protective effect against allergic diseases. Furthermore, recently our study showed that anticancer drug has antiallergic inflammatory effect. An anticancer agent ABT-737 is an inhibitor of Bcl-2 and has an anti-inflammatory effect. However, the antiallergic inflammatory activity of ABT-737 is still unknown. Here, we aimed to explore the anti-atopic dermatitis (AD) activity and the mechanism of ABT-737 in AD models. MATERIALS AND METHODS: HaCaT cells were used for in vitro experiments...
June 29, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29944037/the-anti-inflammation-effect-of-baige-capsule-and-its-principal-components-mixture-in-mcao-rats
#12
Nan Wang, Delu Che, Yingnan Zeng, Jiao Cao, Jue Wang, Tao Zhang
BACKGROUND: Baige (BG) is a compound Chinese herbal preparation, constituted of different position extracts (ethanol extracts from Pueraria lobate and SFE-CO2 extracts from Radix Angelicae dahuricae) of P. lobata and A. dahurica to treat the brain injury in patients. AIM: The goal of this study was to identify the neuroprotective properties of BG and its principal component mixture (PCM) and verify whether the material basis for BG is its PCM. METHODS: Middle cerebral artery occlusion (MCAO) was operated on male Sprague-Dawley rat for 2 h, different doses of BG or PCM or vehicle were gavaged after 3 h of MCAO...
June 26, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29806793/curcumin-reduces-the-expression-of-interleukin-1%C3%AE-and-the-production-of-interleukin-6-and-tumor-necrosis-factor-alpha-by-m1-macrophages-from-patients-with-behcet-s-disease
#13
Mohammad Taghi Palizgir, Maryam Akhtari, Mahdi Mahmoudi, Shayan Mostafaei, Alireza Rezaiemanesh, Farhad Shahram
OBJECTIVE: Behcet's disease (BD) is an auto-inflammatory disorder. Curcumin as a bio-active agent has anti-inflammatory properties. Effects of curcumin on the pathogenesis of BD are still not clear. In this study, we investigated the effect of curcumin on the inflammatory cytokines expression and production in M1 macrophages from BD patients compared with healthy controls. METHODS: Monocytes were collected from 10 healthy controls and 20 active BD patients, differentiated to macrophages by macrophage-colony stimulating factor for 7 d...
May 28, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29493374/in-vitro-immunomodulatory-activity-of-celastrol-against-influenza-a-virus-infection
#14
Niloofar Khalili, Ali Karimi, Mohammad-Taghi Moradi, Hedayatollah Shirzad
CONTEXT: The influenza A virus (IAV) causes severe respiratory disease that remains a leading reason for morbidity and mortality. Previous studies have indicated that influenza complications in addition to viral replication are due to overproduction of pro-inflammatory cytokines. Therefore, a new compound is needed to be used with current antiviral drugs to modulate overproduction of pro-inflammatory cytokines in IAV infection. OBJECTIVE: This study investigated the effect of celastrol on mRNA expression and concentration levels of the pro-inflammatory cytokines tumor necrosis factor alpha (TNFα) and interleukin-6 (IL6) that are induced by influenza A/Puerto Rico/8/34 (H1N1; PR8) in Madin-Darby Canine Kidney (MDCK) cells...
June 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29486619/a-novel-in-vivo-adjuvant-activity-of-kaempferol-enhanced-tbx-21-gata-3-expression-and-peritoneal-cd11c-mhcii-dendritic-cell-infiltration
#15
Divya Singh, Himanshi Tanwar, Sudeshna Das, Lilly Ganju, Shashi Bala Singh
OBJECTIVE: Kaempferol, a natural flavonol present in various traditional medicinal plants, is known to possess potent anti-inflammatory properties. This study was designed to study the adjuvant effect of kaempferol administration along with ovalbumin antigen (K + O) in balb/c mice. METHODS: Mice were immunized with kaempferol (100 and 50 mg/kg body weight) without or with ovalbumin (20 µg/mouse). After priming, booster was administered on day 21. Antigen specific IgG titers and its subtypes, on day 28, were estimated by indirect ELISA...
June 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29486618/involvement-of-il-1%C3%AE-and-il-6-in-antiarrhythmic-properties-of-atorvastatin-in-ouabain-induced-arrhythmia-in-rats
#16
Mahya Najjari, Gholamhassan Vaezi, Vida Hojati, Zahra Mousavi, Azam Bakhtiarian, Vahid Nikoui
PURPOSE: Evidence show that statins possess wide beneficial cardioprotective and anti-inflammatory effects; therefore, in the present experiment, we investigated the antiarrhythmic properties of atorvastatin in ouabain-induced arrhythmia in isolated rat atria and the role of several inflammatory cytokines in this effect. MATERIALS AND METHODS: Male rats were pretreated with either of atorvastatin (10 mg/kg) or vehicle, orally once daily for 6 weeks. After induction of anesthesia, we isolated the atria and after incubation with ouabain, time of onset of arrhythmia and asystole as well as atrial beating rate and contractile force were recorded...
June 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29486614/molecular-mechanism-of-amygdalin-action-in-vitro-review-of-the-latest-research
#17
Przemysław Liczbiński, Bożena Bukowska
Amygdalin, named as 'laetrile' and 'vitamin B-17' was initially supposed to be a safe drug for cancer treatment and was recognized by followers of natural medicine since it has been considered to be hydrolyzed only in cancer cells releasing toxic hydrogen cyanide (HCN), and thus destroying them. Unfortunately, current studies have shown that HCN is also released in normal cells, therefore it may not be safe for human organism. However, there have still been research works conducted on anti-cancer properties of this compound...
June 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29486613/magnesium-isoglycyrrhizinate-attenuates-d-galactosamine-lipopolysaccharides-induced-acute-liver-injury-of-rat-via-regulation-of-the-p38-mapk-and-nf-%C3%AE%C2%BAb-signaling-pathways
#18
Wei Wang, XiaoGuang Li, Jie Xu
CONTEXT: Acute hepatic failure involves in serious inflammatory responses and leads to a high mortality. Magnesium isoglycyrrhizinate (MgIG), a magnesium salt of 18-α glycyrrhizic acid (GA) stereoisomer, has been shown anti-inflammatory activity previously. OBJECTIVE: This study aimed to investigate the protective effects of MgIG, a hepatocyte protective agent, on D-galactosamine and lipopolysaccharide (D-GaIN/LPS)-induced acute liver injury in rats, and meanwhile explore the molecular mechanism...
June 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29473438/crispr-and-personalized-treg-therapy-new-insights-into-the-treatment-of-rheumatoid-arthritis
#19
Fatemeh Safari, Safar Farajnia, Maryam Arya, Habib Zarredar, Ava Nasrolahi
INTRODUCTION: Rheumatoid arthritis (RA), as one of the most disabling autoimmune diseases, is a common health problem that progressively reduces the life quality of patients. Although various biologics have been introduced for RA, attempts to establish an efficient long-term therapies failed due to the heterogeneity of this disease. METHODS: In the last decade, immunomodulatory approaches such as T cell adoptive therapy have been developed for controlling autoimmunity...
June 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29447007/valsartan-attenuates-bleomycin-induced-pulmonary-fibrosis-by-inhibition-of-nf-%C3%AE%C2%BAb-expression-and-regulation-of-th1-th2-cytokines
#20
Hoda Mojiri-Forushani, Ali Asghar Hemmati, Ali Khodadadi, Mohammad Rashno
OBJECTIVE: Pulmonary fibrosis (PF) is a chronic respiratory system disease. The role of inflammation and angiotensin in the development and progression of PF has previously been demonstrated. Alternation in antifibrotic/profibrotic mediators and NF-κB activation have important roles in PF development. NF-κB, a nuclear factor, induces the transcription of inflammatory and pro-inflammatory cytokines. The aim of this study was to evaluate the effect of valsartan as an angiotensin receptor blocker on IL-4, INF-γ, and NF-κB expression in the treatment of PF...
June 2018: Immunopharmacology and Immunotoxicology
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