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Immunopharmacology and Immunotoxicology

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https://www.readbyqxmd.com/read/29806793/curcumin-reduces-the-expression-of-interleukin-1%C3%AE-and-the-production-of-interleukin-6-and-tumor-necrosis-factor-alpha-by-m1-macrophages-from-patients-with-behcet-s-disease
#1
Mohammad Taghi Palizgir, Maryam Akhtari, Mahdi Mahmoudi, Shayan Mostafaei, Alireza Rezaiemanesh, Farhad Shahram
OBJECTIVE: Behcet's disease (BD) is an auto-inflammatory disorder. Curcumin as a bio-active agent has anti-inflammatory properties. Effects of curcumin on the pathogenesis of BD are still not clear. In this study, we investigated the effect of curcumin on the inflammatory cytokines expression and production in M1 macrophages from BD patients compared with healthy controls. METHODS: Monocytes were collected from 10 healthy controls and 20 active BD patients, differentiated to macrophages by macrophage-colony stimulating factor for 7 d...
May 28, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29771163/review-of-saccharomyces-boulardii-as-a-treatment-option-in-ibd
#2
Kavitha Sivananthan, Andreas Munk Petersen
CONTEXT: Review of the yeast Saccharomyces boulardii as a treatment option for the inflammatory bowel diseases (IBD) ulcerative colitis and Crohn's disease. OBJECTIVE: IBD is caused by an inappropriate immune response to gut microbiota. Treatment options could therefore be prebiotics, probiotics, antibiotics and/or fecal transplant. In this review, we have looked at the evidence for the yeast S. boulardii as a treatment option. MATERIAL AND METHODS: Searches in PubMed and the Cochrane Library with the MeSH words 'Saccharomyces boulardii AND IBD', 'Saccharomyces boulardii AND Inflammatory Bowel Disease', 'Saccharomyces boulardii AND ulcerative colitis' and 'Saccharomyces boulardii AND Crohn's disease' gave total a total of 80 articles...
May 17, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29745777/current-experimental-and-future-treatments-in-inflammatory-bowel-disease-a-clinical-review
#3
Christian L Hvas, Mia Bendix, Anders Dige, Jens F Dahlerup, Jørgen Agnholt
Inflammatory bowel diseases (IBDs) may result from dysregulated mucosal immune responses directed toward the resident intestinal microbiota. This review describes the hallmark immunobiology of Crohn's disease and ulcerative colitis as well as therapeutic targets and mechanisms of action for current, experimental, and future treatments in IBD. Conventional therapies include 5-aminosalicylic acid, glucocorticosteroids, thiopurines, and methotrexate. Since 1997, monoclonal antibodies have gained widespread use...
May 10, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29676192/sulfur-mustard-triggers-oxidative-stress-through-glutathione-depletion-and-altered-expression-of-glutathione-related-enzymes-in-human-airways
#4
Issa Layali, Alireza Shahriary, Nima Rahmani Talatappe, Eisa Tahmasbpour, Hossein Rostami, Asghar Beigi Harchegani
CONTEXT: Sulfur mustard (SM) is a lipophilic and reactive chemical compound that targets human airway system. OBJECTIVE: Glutathione (GSH) depletion, oxidative stress (OS) status, and changes in expression of GSH-dependent antioxidant enzymes were considered in human mustard lungs. MATERIALS AND METHODS: Lung biopsies and bronchoalveolar lavage (BAL) were collected from non-exposed (n = 10) individuals and SM-exposed patients (n = 12)...
April 20, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29658372/mir-340-affects-gastric-cancer-cell-proliferation-cycle-and-apoptosis-through-regulating-socs3-jak-stat-signaling-pathway
#5
Chunhong Xiao, Hong Hong, Haizhong Yu, Jianfen Yuan, Chunyan Guo, Hongyan Cao, Weibing Li
OBJECTIVE: Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway is closely related to tumorigenesis. Suppressors of cytokine signaling 3 (SOCS3) is a negative regulator of JAK-STAT signaling pathway. MiR-340 expression is significantly upregulated in gastric cancer (GC) tissue. This study investigated the role of miR-340 in regulating SOCS3 expression and affecting GC cell proliferation, cycle, and apoptosis. PATIENTS AND METHODS: Dual luciferase assay was used to verify the targeted relationship between miR-340 and SOCS3...
April 16, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29619884/cardioprotective-effect-of-%C3%AE-d-mannuronic-acid-m2000-as-a-novel-nsaid-on-gene-expression-of-oxldl-scavenger-receptors-in-the-experimental-diabetic-model
#6
Seyed Shahabeddin Mortazavi-Jahromi, Shahab Alizadeh, Mohammad Hassan Javanbakht, Abbas Mirshafiey
CONTEXT: The investigations have shown that patients with diabetes have the elevated levels of glucose and oxLDL. These two play an important role in increased expression levels of oxLDL scavenger receptors on the surface of macrophages and endothelial cells that leads to deposition of oxLDL and macrophages in vascular walls. OBJECTIVE: The present study intends to show the effects of β-d-mannuronic acid (M2000) on the expression profile of ox-LDL scavenger receptors (including SR-A, LOX-1, CD36, and CD68) in an experimental model of diabetes...
April 5, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29486614/molecular-mechanism-of-amygdalin-action-in-vitro-review-of-the-latest-research
#7
Przemysław Liczbiński, Bożena Bukowska
Amygdalin, named as 'laetrile' and 'vitamin B-17' was initially supposed to be a safe drug for cancer treatment and was recognized by followers of natural medicine since it has been considered to be hydrolyzed only in cancer cells releasing toxic hydrogen cyanide (HCN), and thus destroying them. Unfortunately, current studies have shown that HCN is also released in normal cells, therefore it may not be safe for human organism. However, there have still been research works conducted on anti-cancer properties of this compound...
June 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29447014/macrophage-migration-inhibitory-factor-mif-inhibitor-z-590-suppresses-cartilage-destruction-in-adjuvant-induced-arthritis-via-inhibition-of-macrophage-inflammatory-activation
#8
Zhiyu Zhang, Rong Zhang, Linlang Li, Lijun Zhu, Shiyuan Gao, Qiran Lu, Yihui Gu, Yu Zhang, Huicui Yang, Tingjun Hou, Xuechu Zhen, Long Tai Zheng
BACKGROUND: Macrophage migration inhibitory factor (MIF) is a pleiotropic pro-inflammatory mediator that is involved in the progression of rheumatoid arthritis (RA). Previously, we demonstrated a small molecule compound 3-[(biphenyl-4-ylcarbonyl) carbamothioyl] amino benzoic acid (Z-590) could inhibit MIF activity with docking-based virtual screening and experimental evaluation. METHODS: The LPS activated RAW264.7 macrophage cells were used to determine the anti-inflammatory effects of Z-590 in vitro...
April 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29405080/artesunate-enhances-%C3%AE-%C3%AE-t-cell-mediated-antitumor-activity-through-augmenting-%C3%AE-%C3%AE-t-cell-function-and-reversing-immune-escape-of-hepg2-cells
#9
Peng Qian, Yong-Wen Zhang, Zhong-Hai Zhou, Jun-Quan Liu, Su-Yang Yue, Xiang-Li Guo, Lei-Qing Sun, Xiao-Ting Lv, Jian-Qun Chen
OBJECTIVE: To explore the effect and mechanism of artesunate on γδ T cell-mediated antitumor immune responses against hepatoma carcinoma cells (HepG2) in vitro. METHODS: Human γδ T cells or HepG2 were respectively treated with artesunate, subjected to co-culture as appropriate, and the following assays were subsequently conducted: CCK8 to examine cell viability; LDH release assay to detect the killing effect of γδ T cells on HepG2 cells; flow cytometry to examine the expression of perforin (PFP) and granzyme B (GraB) of γδ T cells; ELISA to evaluate the levels of TGF-β1 and IL-10 in the collected supernatant of HepG2 cells pretreated with artesunate; and Western blot analysis to examine Fas, FasL, STAT3, p-STAT3 expression of HepG2 cells induced by artesunate...
April 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29388481/chemotherapy-alters-the-increased-numbers-of-myeloid-derived-suppressor-and-regulatory-t-cells-in-children-with-acute-lymphoblastic-leukemia
#10
Mohamed Labib Salem, Mohamed R El-Shanshory, Said H Abdou, Mohamed S Attia, Shymaa M Sobhy, Mona F Zidan, Abdel-Aziz A Zidan
INTRODUCTION: Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children. The precise mechanism behind the relapse in this disease is not clearly known. One possible mechanism could be the accumulation of immunosuppressive cells, including myeloid-derived suppressor cells (MDSCs) and T regulatory cells (Tregs ) which we and others have reported to mediate suppression of anti-tumor immune responses. AIM: In this study, we aimed to analyze the numbers of these cells in a population of B-ALL pediatric patients...
April 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29355065/effect-of-combination-of-vitamin-e-and-umbilical-cord-derived-mesenchymal-stem-cells-on-inflammation-in-mice-with-acute-kidney-injury
#11
Qiongqiong Guo, Junxia Wang
BACKGROUND: The objective of this study is to investigate the effect of combination of umbilical cord-derived mesenchymal stem cell (UC-MSC) and vitamin E (VitE) on inflammation in mice with acute kidney injury (AKI). METHODS: UC-MSCs were isolated from pregnant wistar mice and cultured. A total of 90 female wistar mice were randomly divided into control group, AKI group, AKI + VitE group, AKI + UC-MSC group, and AKI + VitE + UC-MSC group (18 mice in each group) which were given no treatment, normal saline, VitE, UC-MSC, and VitE + UC-MSC, respectively...
April 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29355053/harpagoside-induced-anaphylactic-reaction-in-an-ige-independent-manner-both-in-vitro-and-in-vivo
#12
Delu Che, Jiao Cao, Rui Liu, Jue Wang, Yajing Hou, Tao Zhang, Nan Wang
BACKGROUND: Harpagoside (HAR) is an active component of Scrophularia ningpoensis (SN), which has anti-inflammatory and anti-immune effects. SN is used widely in China to treat various diseases. Recently, SN has been used as a traditional Chinese medicine injection and used clinically. However, allergic responses to these injections are frequently reported. AIM: We examined whether the main component of SN, HAR, is associated with the allergic reaction to SN. METHODS: This study assessed the effects of HAR in mice and mast cell activation to characterize its anaphylactic effects and underlying mechanisms...
April 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29350096/%C3%AE-tocopherol-protected-against-cobalt-nanoparticles-and-cocl-2-induced-cytotoxicity-and-inflammation-in-balb-3t3-cells
#13
Xin Yan, Yake Liu, Tian Xie, Fan Liu
CONTEXT: Currently, tissue damage induced by cobalt nanoparticles (CoNPs) and cobalt ions (Co2+ ) are the most serious adverse effect in the patients with metal-on-metal hip prostheses. Therefore, an urgent need exists for the identification of the mechanisms and the development of therapeutic strategies to limit it. OBJECTIVE: We aimed to explore the mechanisms of cytotoxicity of CoNPs and Co2+ and developed strategies to reduce this cytotoxicity with α-tocopherol treatment...
April 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29303022/cardamonin-inhibits-pro-inflammatory-cytokine-production-and-suppresses-no-pathway-in-pbmcs-from-patients-with-primary-sj%C3%A3-gren-s-syndrome
#14
Sarah Benchabane, Houda Belguendouz, Nassima Behairi, Amina Arroul-Lammali, Abdelhalim Boudjelida, Pierre Youinou, Chafia Touil-Boukoffa
Primary Sjögren's syndrome (pSS) is a systemic autoimmune disorder with a complex pathophysiology primarily affecting exocrine glands, leading to compromised secretory function. Recent studies imply that many inflammatory mediators, such as pro-inflammatory cytokines and nitric oxide, are critical in the development and perpetuation of pSS systemic manifestations. In the current study, we aimed to investigate the ex vivo immunomodulatory effect of cardamonin (C16 H14 O4 ), on pro-inflammatory cytokines, TNF-α, IL-6 and inducible nitric oxide synthase (iNOS) expression during pSS...
April 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29303021/therapeutic-effect-of-acetazolamide-an-aquaporin-1-inhibitor-on-adjuvant-induced-arthritis-in-rats-by-inhibiting-nf-%C3%AE%C2%BAb-signal-pathway
#15
Li Cai, Wei-Na Chen, Rong Li, Cheng-Mu Hu, Chao Lei, Chun-Mei Li
OBJECTIVES: Previous studies have shown that aquaporin 1 (AQP1) is up-regulated in synovium and cartilage of rheumatoid arthritis (RA) patients and that AQP1 may be involved in joint swelling and synovial inflammation. This study was aimed to investigate the potential therapeutic effect of acetazolamide (AZ, an AQP1 inhibitor) on rat adjuvant-induced arthritis (AIA) and explore its related mechanisms. MATERIALS AND METHODS: Rat AIA was induced by complete Freund's adjuvant...
April 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29303018/the-%C3%AE-2-adrenoceptor-agonist-clenbuterol-reduces-the-neuroinflammatory-response-neutrophil-infiltration-and-apoptosis-following-intra-striatal-il-1%C3%AE-administration-to-rats
#16
Éadaoin W Griffin, Justin D Yssel, Eoin O'Neill, Katie J Ryan, Noreen Boyle, Peter Harper, Andrew Harkin, Thomas Connor
OBJECTIVES: Clenbuterol is a brain penetrant β2 -adrenoceptor agonist with anti-inflammatory and putative neuroprotective properties. In the present investigation, the effect of clenbuterol was assessed in a rat model of acute brain injury induced by intra-striatal administration of the pro-inflammatory cytokine IL-1β. METHODS: Clenbuterol (0.5 mg/kg; i.p.) was administered one hour prior to stereotactically delivered IL-1β (100 ng) into the striatum. Four hours postinjection, rats were anesthetized, blood samples were collected for circulating cytokine and chemokine analysis, and the ipsilateral striatum and liver tissue were harvested for mRNA expression analysis of target genes...
April 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29303013/inhibition-of-plasma-kallikrein-kinin-system-to-alleviate-renal-injury-and-arthritis-symptoms-in-rats-with-adjuvant-induced-arthritis
#17
Jie Zhu, Hui Wang, Jingyu Chen, Wei Wei
BACKGROUND: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Impairment of kidney functions in RA was observed. However, the mechanism of kidney injury of RA has not been clear. Plasma kallikrein-kinin system (KKS) was involved in inflammatory processes in kidney disease. AIM: This study aimed to explore the role of plasma KKS in immune reactions and kidney injury of RA. RESULTS: The paw of AA rats appeared to be swelling and redness, the arthritis index was significantly increased on the 18, 21 and 24 d after injection and secondary inflammation in multi-sites was observed...
April 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29493374/in-vitro-immunomodulatory-activity-of-celastrol-against-influenza-a-virus-infection
#18
Niloofar Khalili, Ali Karimi, Mohammad-Taghi Moradi, Hedayatollah Shirzad
CONTEXT: The influenza A virus (IAV) causes severe respiratory disease that remains a leading reason for morbidity and mortality. Previous studies have indicated that influenza complications in addition to viral replication are due to overproduction of pro-inflammatory cytokines. Therefore, a new compound is needed to be used with current antiviral drugs to modulate overproduction of pro-inflammatory cytokines in IAV infection. OBJECTIVE: This study investigated the effect of celastrol on mRNA expression and concentration levels of the pro-inflammatory cytokines tumor necrosis factor alpha (TNFα) and interleukin-6 (IL6) that are induced by influenza A/Puerto Rico/8/34 (H1N1; PR8) in Madin-Darby Canine Kidney (MDCK) cells...
March 1, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29486619/a-novel-in-vivo-adjuvant-activity-of-kaempferol-enhanced-tbx-21-gata-3-expression-and-peritoneal-cd11c-mhcii-dendritic-cell-infiltration
#19
Divya Singh, Himanshi Tanwar, Sudeshna Das, Lilly Ganju, Shashi Bala Singh
OBJECTIVE: Kaempferol, a natural flavonol present in various traditional medicinal plants, is known to possess potent anti-inflammatory properties. This study was designed to study the adjuvant effect of kaempferol administration along with ovalbumin antigen (K + O) in balb/c mice. METHODS: Mice were immunized with kaempferol (100 and 50 mg/kg body weight) without or with ovalbumin (20 µg/mouse). After priming, booster was administered on day 21. Antigen specific IgG titers and its subtypes, on day 28, were estimated by indirect ELISA...
February 28, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29486618/involvement-of-il-1%C3%AE-and-il-6-in-antiarrhythmic-properties-of-atorvastatin-in-ouabain-induced-arrhythmia-in-rats
#20
Mahya Najjari, Gholamhassan Vaezi, Vida Hojati, Zahra Mousavi, Azam Bakhtiarian, Vahid Nikoui
PURPOSE: Evidence show that statins possess wide beneficial cardioprotective and anti-inflammatory effects; therefore, in the present experiment, we investigated the antiarrhythmic properties of atorvastatin in ouabain-induced arrhythmia in isolated rat atria and the role of several inflammatory cytokines in this effect. MATERIALS AND METHODS: Male rats were pretreated with either of atorvastatin (10 mg/kg) or vehicle, orally once daily for 6 weeks. After induction of anesthesia, we isolated the atria and after incubation with ouabain, time of onset of arrhythmia and asystole as well as atrial beating rate and contractile force were recorded...
February 28, 2018: Immunopharmacology and Immunotoxicology
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