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Immunopharmacology and Immunotoxicology

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https://www.readbyqxmd.com/read/28975862/evaluation-of-anti-sepsis-activity-by-compounds-with-high-affinity-to-lipid-a-from-huanglianjiedu-decoction
#1
Yubin Xu, Song Guo, Guirong Chen, Mingbo Zhang, Xu Zhang, Deqiang Dou
CONTEXT: HuanglianJiedu decoction (HJD) is a classic prescription for heat-clearing away and detoxifying, which is used for the clinical treatment of sepsis, due to sepsis refers to the systemic inflammatory response induced by infection in western medicine, and infection belongs to the category of poison-heat syndrome in traditional Chinese medicine. OBJECTIVES: Previous study had elucidated the effective components from HJD with high affinity to lipid A, which can generate the release of pro-inflammatory-cytokines, resulting in sepsis...
October 4, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28952817/artemisinin-therapeutic-efficacy-in-the-experimental-model-of-multiple-sclerosis
#2
Mohammad Reza Khakzad, Ali Ganji, Vahid Ariabod, Iman Farahani
CONTEXT: The immune system through T-helper 1 (Th1) and Th17 cells play a critical role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), whereas the Th2 responses inhibit myelin degeneration. Artemisinin, as an anti-malaria as its agent, has been used widely in the treatment of malaria, shifts the lymphocyte responses from Th1 to Th2. OBJECTIVE: In this study, we have investigated the therapeutic effects of artemisinin on the EAE treatment...
September 27, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28948855/the-gastroprotective-effect-of-nobiletin-against-ethanol-induced-acute-gastric-lesions-in-mice-impact-on-oxidative-stress-and-inflammation
#3
Weifeng Li, Xiumei Wang, Wenbing Zhi, Hailin Zhang, Zehong He, Yu Wang, Fang Liu, Xiaofeng Niu, Xuemei Zhang
CONTEXT: Gastric ulcer is a common gastrointestinal disorder with increasing incidence and prevalence attributed to loss of balance between aggressive and protective factors. Nobiletin (NOB), a major component of polymethoxyflavones in citrus fruits, has a broad spectrum of health beneficial properties including anti-inflammatory and anti-tumor activities. Although NOB was originally shown to possess anti-inflammatory activity, its effects on gastric ulcer were rarely explored previously...
September 26, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28929835/dab389il-2-recombinant-fusion-toxin-effect-on-lymphocyte-and-macrophage-producing-cytokine-subpopulation-cells-in-experimentally-induced-demyelinating-disease-in-mice
#4
Mahendra K Bhopale, Brendan Hilliard, Cris S Constantinescu, S Michael Phillips, Abdolmohamad Rostami
CONTEXT: We have reported previously that DAB389IL-2 recombinant fusion toxin targets IL-2R bearing CD4(+) cells, and suppresses demyelinating disease in acute (A) - and chronic (C) - experimental autoimmune encephalomyelitis (EAE) animal models of multiple sclerosis. OBJECTIVES: The present study was undertaken to investigate the effect of DAB389IL-2 treatment on various cytokine-secreting cell populations in A-EAE and C-EAE mice. MATERIALS AND METHODS: The effects of DAB389IL-2 at doses of 200-, 800-, or 1600 kU administered i...
September 20, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28879797/amorfrutin-a-inhibits-tnf-%C3%AE-induced-jak-stat-signaling-cell-survival-and-proliferation-of-human-cancer-cells
#5
Chunliu Mi, Juan Ma, Ke Si Wang, Zhe Wang, Ming Yue Li, Jun Bo Li, Xuezheng Li, Lian Xun Piao, Guang Hua Xu, Xuejun Jin
CONTEXT: Amorfrutin A is a natural product isolated from the fruits of Amorpha fruticosa L. and has been shown to exhibit multiple bioeffector functions. In the present study, we investigated whether amorfrutin A exerts anticancer effects by inhibiting STAT3 activation in cervical cancer cells. OBJECTIVE: To investigate the effectiveness of amorfrutin A as a treatment of cancer, and determine the underlying pharmacological mechanism of action. MATERIALS AND METHODS: HeLa, SK-Hep1, MDA-MB-231 and HCT116 cells were used in this study...
September 7, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28872362/ferulic-acid-but-not-alpha-lipoic-acid-effectively-protects-thp-1-derived-macrophages-from-oxidant-and-pro-inflammatory-response-to-lps
#6
Izabela Szulc-Kielbik, Michal Kielbik, Magdalena Klink
OBJECTIVE: The diet supplementation with antioxidants-rich products is a way to protect people from free radical-induced diseases. In this study, we compare the anti-inflammatory/antioxidant activity of two compounds available as supplements: alpha lipoic acid (ALA) and ferulic acid (FA). MATERIALS AND METHODS: The free radical scavenging capacity of ALA and FA in the cell free system was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Anti-inflammatory activity of both compounds was determined, in vitro, on THP-1 derived macrophages model, both resting (not stimulated) and inflammatory (lipopolysaccharide- or tumor-necrosis factor α-stimulated)...
September 5, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28828896/toxicological-effects-of-trichloroethylene-exposure-on-immune-disorders
#7
Josue D Ordaz, Nur P Damayanti, Joseph M K Irudayaraj
Trichloroethylene (TCE) is one of the most common ground water contaminants in USA. Even though recent regulation mandates restricted utilization of TCE, its use is not completely prohibited, especially in industrial and manufacturing processes. The risk of TCE on human health is an ongoing field of study and its implications on certain diseases such as cancer has been recognized and well-documented. However, the link between TCE and immune disorders is still an under-studied area. Studies on the risk of TCE on the immune system is usually focused on certain immune class disorders, but consensus on the impact of TCE on the immune system has not been established...
August 22, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28762847/inhibition-of-nlrp3-inflammasome-a-new-protective-mechanism-of-cinnamaldehyde-in-endotoxin-poisoning-of-mice
#8
Feng Xu, Feng Wang, Taoqun Wen, Wentao Sang, Dejian Wang, Nan Zeng
CONTEXT: Cinnamaldehyde (CA) has a protective effect in endotoxin poisoning of mice, but there is no direct evidence for the protective effect of CA through inhibition of NLRP3 inflammasome activation in endotoxin poisoning of mice. OBJECTIVE: We aimed to investigate the protective mechanism of CA in endotoxin poisoned mice through NLRP3 inflammasome. MATERIALS AND METHODS: First, we evaluated the anti-inflammatory effect of CA in phorbol-12-myristate acetate-differentiated THP-1 cells through the NLRP3 inflammasome...
August 1, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28747139/a-monoclonal-antibody-against-cd86-and-its-protection-in-a-murine-lupus-nephritis-model-of-chronic-graft-versus-host-disease
#9
Lianhua Han, Lijun Shen, Ying Zhu, Yuhua Qiu
CONTEXT: Lupus nephritis is the most common complication that causes the death of systemic lupus erythematosus patients. CD28/CTLA4 and their ligands CD80 or CD86 costimulatory pathway play a pivotal role in autoimmune disease and organ transplantation. OBJECTIVES: We generated a monoclonal antibody (clone 1D1) against human CD86 (1D1) that could recognize both human and mouse CD86, and blocked the CD86/CD28 costimulatory pathway with our mAb on a murine lupus nephritis model induced with chronic graft-versus-host disease (cGVHD)...
July 26, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28745076/effects-of-ici204-448-naloxone-methiodide-and-levocetirizine-on-the-scratching-behavior-induced-by-a-%C3%AE%C2%BA-opioid-antagonist-nor-bni-in-icr-mice
#10
Tasuku Nakasone, Hirokazu Wakuda, Yumi Sugimoto, Chiaki Kamei
OBJECTIVE: In this study, we aimed to study the effects of ICI204,448, naloxone methiodide and levocetirizine on the scratching behavior induced by intradermal injection of a ?-opioid antagonist, nor-binaltorphimine (nor-BNI), into the rostral back of ICR mice were investigated. MATERIALS AND METHODS: Male ICR mice weighing 30?35 g were used. The number of scratching episodes were counted for 60 min after i.d. injection of nor-BNI. RESULTS: nor-BNI dose dependently increased in the number of scratching episodes in ICR mice...
July 26, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28555525/hepatoprotective-effect-of-parthenolide-in-rat-model-of-nonalcoholic-fatty-liver-disease
#11
Majid Bahabadi, Adel Mohammadalipour, Jamshid Karimi, Nasrin Sheikh, Ghasem Solghi, Farjam Goudarzi, Mohammad Hashemnia, Iraj Khodadadi
CONTEXT: The active ingredients of traditional medical herbs have been the focus of scientific interests. OBJECTIVE: This study was designed to explore the mechanisms of actions of parthenolide on nonalcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS: Thirty-five male Wistar rats were fed high-fat diet (HFD) for eight weeks with or without an intraperitoneal injection of parthenolide to develop NAFLD. Liver triacylglycerol (TG), total antioxidant capacity (TAC), total oxidative status (TOS), thiobarbituric acid reactant substances (TBARs), total thiol groups and tumor necrosis factor alpha (TNF-α) and cytochrome P4502E1 (CYP2E1) levels as well as liver ALT, AST and catalase activities were determined...
August 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28555511/mitigation-of-inflammation-using-the-intravenous-anesthetic-dexmedetomidine-in-the-mouse-air-pouch-model
#12
Takefumi Inada, Chisato Sumi, Kiichi Hirota, Koh Shingu, Akihisa Okamoto, Yoshiyuki Matsuo, Takahiko Kamibayashi
Dexmedetomidine, an α2-adrenergic/imidazoline receptor agonist, is a widely used intravenous anesthetic. Its primary current usage is for sedation of patients in the intensive care unit. The mouse air pouch model is versatile in studying the anti-inflammatory effect of a drug on a local inflammation, which is induced by a variety of substances. In the present study, using the carrageenan-induced air pouch inflammation model, we tested whether dexmedetomidine mitigates inflammation occurring locally in the mouse air pouch...
August 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28532201/vitamin-d-status-in-algerian-beh%C3%A3-et-s-disease-patients-an-immunomodulatory-effect-on-no-pathway
#13
Zineb Djeraba, Fatiha Benlabidi, Fatma Zohra Djaballah-Ider, Oussama Medjeber, Amina Arroul-Lammali, Houda Belguendouz, Fifi Otmani, Chafia Touil-Boukoffa
Behçet's disease (BD) is an inflammatory multisystemic disorder associated with orogenital ulcers, uveitis and skin lesions with unpredictable episodes of exacerbations and remissions. Even though several immunological and environmental factors contribute to BD progression, its ethiopathogenesis remains uncertain and elusive. Considered as one of the potent environmental factors that can increase prevalence of some autoimmune and inflammatory disorders, vitamin D deficiency has been linked to several diseases as BD...
August 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28523957/clinical-case-idelalisib-induced-immunoglobulin-flare
#14
Jan Novak, Martin Havrda, Lubica Gaherova, Jan Spicka, Tomas Kozak
IgM flare is a transient, treatment-induced, increase of monoclonal IgM levels in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) patients. Until recently this phenomenon was observed in patients treated with Cladribine and Rituximab. Here we report a case of a heavily pretreated chronic lymphocytic leukemia patient with an atypically high immunoglobulin production who developed clinically significant immunoglobulin flare following Idelalisib treatment.
August 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28724326/sting-signalling-an-emerging-common-pathway-in-autoimmunity-and-cancer
#15
David McCaffary
The equipoise between the disease states of cancer and autoinflammation has perhaps been underappreciated in clinical practice and biomedical research. However, since the discover of STING (stimulator of interferon genes) as an integral regulator of innate immunity, a wealth of information has implicated this signaling pathway in both of these diseases. Under cellular homeostasis, STING serves to detect - and promote immune defense against - DNA viruses and intracellular bacteria, as described in its initial discovery...
July 20, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28669260/andrographolide-attenuates-microglia-mediated-a%C3%AE-neurotoxicity-partially-through-inhibiting-nf-%C3%AE%C2%BAb-and-jnk-mapk-signaling-pathway
#16
Rui Yang, Sha Liu, Jia Zhou, Shuhong Bu, Jian Zhang
Neuroinflammation plays a critical role in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease (AD). Microglial cells after activated play critical roles in development of neuroinflammation, and may accelerate the progression of AD. Andrographolide (ANDRO), a potent naturally extracted substance, has been demonstrated to exert suppressive effects on LPS-induced inflammation by modulating macrophage and microglia overactivation. Whereas in AD, β-amyloid (Aβ) peptides have been considered as a potent activator of neuroinflammation, the effect of ANDRO on Aβ-induced neuroinflammation has not been examined...
July 18, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28703078/chrysophanol-suppresses-pro-inflammatory-response-in-microglia-via-regulation-of-drp1-dependent-mitochondrial-fission
#17
Unbin Chae, Ju-Sik Min, Hanna Lee, Kyung-Sik Song, Hyun-Shik Lee, Hong Jun Lee, Sang-Rae Lee, Dong-Seok Lee
OBJECTIVES: Chrysophanol, also called chrysophanic acid, is a natural anthraquinone compound found in Rheum palmatum. R. palmatum has been used in oriental medicine in ancient East Asia. Microglial cells represent not only the forefront immune defense in the central nervous system but also the most reactive sensors to various threats. However, activated microglia can exert neurotoxic effects via excessive production of cytotoxic molecules and proinflammatory cytokines. Therefore, modulation of microglial cell activation is important for maintaining neuronal function...
July 13, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28697633/zinc-l-carnosine-suppresses-inflammatory-responses-in-lipopolysaccharide-induced-raw-264-7-murine-macrophages-cell-line-via-activation-of-nrf2-ho-1-signaling-pathway
#18
Theng Choon Ooi, Kok Meng Chan, Razinah Sharif
CONTEXT: Zinc L-carnosine (ZnC) is a chelate of Zn and L-carnosine and is used clinically in the treatment of peptic ulcer. OBJECTIVE: In this study, we aim to investigate the involvement of heme oxygenase-1 (HO-1) in the anti-inflammatory effects of ZnC in lipopolysaccharide (LPS)-induced RAW 264.7 murine macrophages. MATERIALS AND METHODS: We used immunoblotting analysis to evaluate the involvement of HO-1 in the anti-inflammatory effects of ZnC and the signaling pathway involved was measured using Dual luciferase reporter assay...
July 11, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28691883/correction-to-bahabadi-m-et-al-hepatoprotective-effect-of-parthenolide-in-rat-model-of-nonalcoholic-fatty-liver-disease
#19
(no author information available yet)
No abstract text is available yet for this article.
July 10, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28418286/external-application-of-nf-%C3%AE%C2%BAb-inhibitor-dhmeq-suppresses-development-of-atopic-dermatitis-like-lesions-induced-with-dncb-ox-in-balb-c-mice
#20
Xiaoxue Jiang, Yi Lan, Bing Wei, Cailing Dai, Yaru Gu, Jun Ma, Xiaoyan Liu, Kazuo Umezawa, Yuyang Zhang
CONTEXT: Dehydroxymethylepoxyquinomicin (DHMEQ) which is originally developed as an analog of antibiotic epoxyquinomicin C is a specific and potent inhibitor of NF-κB and has been shown to possess promising potential as an anti-inflammatory and anti-tumor agent. OBJECTIVE: This study examines DHMEQ's effect on therapeutic potential for atopic dermatitis (AD)-like lesions. MATERIALS AND METHODS: AD lesions were chronically induced by the repetitive and alternative application of 2,4-dinitrochlorobenzene (DNCB) and oxazolone (OX) on ears in BALB/c mice...
June 2017: Immunopharmacology and Immunotoxicology
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