journal
MENU ▼
Read by QxMD icon Read
search

Immunopharmacology and Immunotoxicology

journal
https://www.readbyqxmd.com/read/28762847/inhibition-of-nlrp3-inflammasome-a-new-protective-mechanism-of-cinnamaldehyde-in-endotoxin-poisoning-of-mice
#1
Feng Xu, Feng Wang, Taoqun Wen, Wentao Sang, Dejian Wang, Nan Zeng
CONTEXT: Cinnamaldehyde (CA) has a protective effect in endotoxin poisoning of mice, but there is no direct evidence for the protective effect of CA through inhibition of NLRP3 inflammasome activation in endotoxin poisoning of mice. OBJECTIVE: We aimed to investigate the protective mechanism of CA in endotoxin poisoned mice through NLRP3 inflammasome. MATERIALS AND METHODS: First, we evaluated the anti-inflammatory effect of CA in phorbol-12-myristate acetate-differentiated THP-1 cells through the NLRP3 inflammasome...
August 1, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28747139/a-monoclonal-antibody-against-cd86-and-its-protection-in-a-murine-lupus-nephritis-model-of-chronic-graft-versus-host-disease
#2
Lianhua Han, Lijun Shen, Ying Zhu, Yuhua Qiu
CONTEXT: Lupus nephritis is the most common complication that causes the death of systemic lupus erythematosus patients. CD28/CTLA4 and their ligands CD80 or CD86 costimulatory pathway play a pivotal role in autoimmune disease and organ transplantation. OBJECTIVES: We generated a monoclonal antibody (clone 1D1) against human CD86 (1D1) that could recognize both human and mouse CD86, and blocked the CD86/CD28 costimulatory pathway with our mAb on a murine lupus nephritis model induced with chronic graft-versus-host disease (cGVHD)...
July 26, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28745076/effects-of-ici204-448-naloxone-methiodide-and-levocetirizine-on-the-scratching-behavior-induced-by-a-%C3%AE%C2%BA-opioid-antagonist-nor-bni-in-icr-mice
#3
Tasuku Nakasone, Hirokazu Wakuda, Yumi Sugimoto, Chiaki Kamei
OBJECTIVE: In this study, we aimed to study the effects of ICI204,448, naloxone methiodide and levocetirizine on the scratching behavior induced by intradermal injection of a ?-opioid antagonist, nor-binaltorphimine (nor-BNI), into the rostral back of ICR mice were investigated. MATERIALS AND METHODS: Male ICR mice weighing 30?35 g were used. The number of scratching episodes were counted for 60 min after i.d. injection of nor-BNI. RESULTS: nor-BNI dose dependently increased in the number of scratching episodes in ICR mice...
July 26, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28724326/sting-signalling-an-emerging-common-pathway-in-autoimmunity-and-cancer
#4
David McCaffary
The equipoise between the disease states of cancer and autoinflammation has perhaps been underappreciated in clinical practice and biomedical research. However, since the discover of STING (stimulator of interferon genes) as an integral regulator of innate immunity, a wealth of information has implicated this signaling pathway in both of these diseases. Under cellular homeostasis, STING serves to detect - and promote immune defense against - DNA viruses and intracellular bacteria, as described in its initial discovery...
July 20, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28669260/andrographolide-attenuates-microglia-mediated-a%C3%AE-neurotoxicity-partially-through-inhibiting-nf-%C3%AE%C2%BAb-and-jnk-mapk-signaling-pathway
#5
Rui Yang, Sha Liu, Jia Zhou, Shuhong Bu, Jian Zhang
Neuroinflammation plays a critical role in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease (AD). Microglial cells after activated play critical roles in development of neuroinflammation, and may accelerate the progression of AD. Andrographolide (ANDRO), a potent naturally extracted substance, has been demonstrated to exert suppressive effects on LPS-induced inflammation by modulating macrophage and microglia overactivation. Whereas in AD, β-amyloid (Aβ) peptides have been considered as a potent activator of neuroinflammation, the effect of ANDRO on Aβ-induced neuroinflammation has not been examined...
July 18, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28703078/chrysophanol-suppresses-pro-inflammatory-response-in-microglia-via-regulation-of-drp1-dependent-mitochondrial-fission
#6
Unbin Chae, Ju-Sik Min, Hanna Lee, Kyung-Sik Song, Hyun-Shik Lee, Hong Jun Lee, Sang-Rae Lee, Dong-Seok Lee
OBJECTIVES: Chrysophanol, also called chrysophanic acid, is a natural anthraquinone compound found in Rheum palmatum. R. palmatum has been used in oriental medicine in ancient East Asia. Microglial cells represent not only the forefront immune defense in the central nervous system but also the most reactive sensors to various threats. However, activated microglia can exert neurotoxic effects via excessive production of cytotoxic molecules and proinflammatory cytokines. Therefore, modulation of microglial cell activation is important for maintaining neuronal function...
July 13, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28697633/zinc-l-carnosine-suppresses-inflammatory-responses-in-lipopolysaccharide-induced-raw-264-7-murine-macrophages-cell-line-via-activation-of-nrf2-ho-1-signaling-pathway
#7
Theng Choon Ooi, Kok Meng Chan, Razinah Sharif
CONTEXT: Zinc L-carnosine (ZnC) is a chelate of Zn and L-carnosine and is used clinically in the treatment of peptic ulcer. OBJECTIVE: In this study, we aim to investigate the involvement of heme oxygenase-1 (HO-1) in the anti-inflammatory effects of ZnC in lipopolysaccharide (LPS)-induced RAW 264.7 murine macrophages. MATERIALS AND METHODS: We used immunoblotting analysis to evaluate the involvement of HO-1 in the anti-inflammatory effects of ZnC and the signaling pathway involved was measured using Dual luciferase reporter assay...
July 11, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28691883/correction-to-bahabadi-m-et-al-hepatoprotective-effect-of-parthenolide-in-rat-model-of-nonalcoholic-fatty-liver-disease
#8
(no author information available yet)
No abstract text is available yet for this article.
July 10, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28555524/ellipticine-inhibits-the-proliferation-and-induces-apoptosis-in-rheumatoid-arthritis-fibroblast-like-synoviocytes-via-the-stat3-pathway
#9
Hui-Long Wen, Guang Yang, Qi-Rong Dong
OBJECTIVE: Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is an alkaloid isolated from Apocyanaceae plants. This study was designed to investigate the effects of ellipticine on the proliferation and apoptosis of fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA). METHODS: RA-FLSs were exposed to different concentrations of ellipticine (i.e., 0.5, 1, 2, 4 and 8 μM) for 24-72h and measured for viability, proliferation and apoptosis...
May 30, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28555509/inhibitory-effects-of-propofol-on-th17-cell-differentiation
#10
Chi-Chien Lin, Der-Yuan Chen, Kuo-Tung Tang, Ya-Hsuan Chao, Ching-Hui Shen, Ping-Wing Lui
Propofol (2,6-diisopropylphenol) is probably the most widely used intravenous anesthetic agent in daily practice. It has been reported to show immunomodulatory activity. However, the effect of propofol on the differention of T cells remains unclear. In this study, we demonstrated for the first time that propofol inhibited both interleukin (IL)-6 plus transforming growth factor-β (TGF-β)-induced Th17 cell differentiation in vitro and in LPS-challenged mice. Propofol also suppressed the IL-6-induced phosphorylation of Janus kinase-2 (JAK2)/signal transducer and activator of transcription (STAT3) pathway, a cytokine-activated essential transcription factor in Th17 cell development, which occurred concomitantly with the enhancement of suppressor of cytokine signaling-3 (SOCS3) expression involved in the downregulation of STAT3 phosphorylation...
May 30, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28555525/hepatoprotective-effect-of-parthenolide-in-rat-model-of-nonalcoholic-fatty-liver-disease
#11
Majid Bahabadi, Adel Mohammadalipour, Jamshid Karimi, Nasrin Sheikh, Ghasem Solghi, Farjam Goudarzi, Mohammad Hashemnia, Iraj Khodadadi
CONTEXT: The active ingredients of traditional medical herbs have been the focus of scientific interests. OBJECTIVE: This study was designed to explore the mechanisms of actions of parthenolide on nonalcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS: Thirty-five male Wistar rats were fed high-fat diet (HFD) for eight weeks with or without an intraperitoneal injection of parthenolide to develop NAFLD. Liver triacylglycerol (TG), total antioxidant capacity (TAC), total oxidative status (TOS), thiobarbituric acid reactant substances (TBARs), total thiol groups and tumor necrosis factor alpha (TNF-α) and cytochrome P4502E1 (CYP2E1) levels as well as liver ALT, AST and catalase activities were determined...
August 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28555511/mitigation-of-inflammation-using-the-intravenous-anesthetic-dexmedetomidine-in-the-mouse-air-pouch-model
#12
Takefumi Inada, Chisato Sumi, Kiichi Hirota, Koh Shingu, Akihisa Okamoto, Yoshiyuki Matsuo, Takahiko Kamibayashi
Dexmedetomidine, an α2-adrenergic/imidazoline receptor agonist, is a widely used intravenous anesthetic. Its primary current usage is for sedation of patients in the intensive care unit. The mouse air pouch model is versatile in studying the anti-inflammatory effect of a drug on a local inflammation, which is induced by a variety of substances. In the present study, using the carrageenan-induced air pouch inflammation model, we tested whether dexmedetomidine mitigates inflammation occurring locally in the mouse air pouch...
August 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28532201/vitamin-d-status-in-algerian-beh%C3%A3-et-s-disease-patients-an-immunomodulatory-effect-on-no-pathway
#13
Zineb Djeraba, Fatiha Benlabidi, Fatma Zohra Djaballah-Ider, Oussama Medjeber, Amina Arroul-Lammali, Houda Belguendouz, Fifi Otmani, Chafia Touil-Boukoffa
Behçet's disease (BD) is an inflammatory multisystemic disorder associated with orogenital ulcers, uveitis and skin lesions with unpredictable episodes of exacerbations and remissions. Even though several immunological and environmental factors contribute to BD progression, its ethiopathogenesis remains uncertain and elusive. Considered as one of the potent environmental factors that can increase prevalence of some autoimmune and inflammatory disorders, vitamin D deficiency has been linked to several diseases as BD...
August 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28523957/clinical-case-idelalisib-induced-immunoglobulin-flare
#14
Jan Novak, Martin Havrda, Lubica Gaherova, Jan Spicka, Tomas Kozak
IgM flare is a transient, treatment-induced, increase of monoclonal IgM levels in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) patients. Until recently this phenomenon was observed in patients treated with Cladribine and Rituximab. Here we report a case of a heavily pretreated chronic lymphocytic leukemia patient with an atypically high immunoglobulin production who developed clinically significant immunoglobulin flare following Idelalisib treatment.
August 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28418286/external-application-of-nf-%C3%AE%C2%BAb-inhibitor-dhmeq-suppresses-development-of-atopic-dermatitis-like-lesions-induced-with-dncb-ox-in-balb-c-mice
#15
Xiaoxue Jiang, Yi Lan, Bing Wei, Cailing Dai, Yaru Gu, Jun Ma, Xiaoyan Liu, Kazuo Umezawa, Yuyang Zhang
CONTEXT: Dehydroxymethylepoxyquinomicin (DHMEQ) which is originally developed as an analog of antibiotic epoxyquinomicin C is a specific and potent inhibitor of NF-κB and has been shown to possess promising potential as an anti-inflammatory and anti-tumor agent. OBJECTIVE: This study examines DHMEQ's effect on therapeutic potential for atopic dermatitis (AD)-like lesions. MATERIALS AND METHODS: AD lesions were chronically induced by the repetitive and alternative application of 2,4-dinitrochlorobenzene (DNCB) and oxazolone (OX) on ears in BALB/c mice...
June 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28378599/liposomal-microparticle-injection-can-induce-myeloid-derived-suppressor-cells-mdsc-like-cells-in-vivo
#16
Hiroshi Azuma, Yoichiro Yoshida, Hironori Takahashi, Emi Ishibazawa, Hiroya Kobayashi, Hiromi Sakai, Daisuke Takahashi, Mitsuhiro Fujihara
CONTEXT: Myeloid-derived suppressor cells (MDSCs) are a subset of immature myeloid cells that function as immunosuppressive cells in various pathological conditions. Membrane-derived microvesicles are thought to be involved in MDSC induction. Earlier reports have described that injection of considerable amount of liposome into rat can suppress Con A-induced splenic T-cell proliferation. Liposome-internalized cells expressing CD11b/c suppress T-cell proliferation. Nitric oxide (NO) appears to be involved in the suppression...
June 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28367652/astragaloside-iv-inhibits-pma-induced-epcr-shedding-through-mapks-and-pkc-pathway
#17
Yu Ma, Yi Zhao, Ran Zhang, Xiaoxia Liang, Zhongqiong Yin, Yi Geng, Gang Shu, Xu Song, Yuanfeng Zou, Lixia Li, Lizi Yin, Guizhou Yue, Yinglun Li, Gang Ye, Changliang He
Astragaloside IV (AS-IV), a main active substance isolated from Astragalus membranaceus Bunge, has been shown to have multiple pharmacological effects. Endothelial cell protein C receptor (EPCR) is a marker of inflammation, and is also a major member of protein C (PC) anti-coagulation system. EPCR can be cut off from the cell surface by tumor necrosis factor-α converting enzyme (TACE), which is controlled through mitogen-activated protein kinase (MAPK) and protein kinase C (PKC) pathways. To develop novel therapeutic drug for EPCR shedding, the effect of AS-IV was studied in phorbol-12-myristate 13-acetate (PMA)-induced human umbilical vein endothelial cells (HUVECs) and the potential molecular mechanism of AS-IV action was investigated...
June 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28303727/enhancement-of-nk-cells-proliferation-and-function-by-shikonin
#18
Yan Li, Hailin Lu, Yongchun Gu, Zhiqiang Ning, Tinghua Cao, Chao Chen, Chengru Hu, Min Tao
CONTEXT: Shikonin is a kind of naphthoquinone compound found mainly in Lithospermum erythrorhizon Sieb,et Zucc. Previous studies have shown that Shikonin has anti-tumor, anti-inflammatory and extensive pharmacological effects. According to new studies, Shikonin could also modulate the immune system function, but the effect to NK (nature killer) cells is yet unknown. OBJECTIVE: To investigate the effect and mechanism of Shikonin on NK cells proliferation and cytotoxicity to colon cancer cell line (Caco-2)...
June 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28290732/cycloastragenol-mediates-activation-and-proliferation-suppression-in-concanavalin-a-induced-mouse-lymphocyte-pan-activation-model
#19
Chenghong Sun, Mingmin Jiang, Li Zhang, Jian Yang, Guimin Zhang, Bingyuan Du, Yushan Ren, Xin Li, Jingchun Yao
CONTEXT: Cycloastragenol (CAG) is a molecule isolated from various species in the genus Astragalus. Although the regulatory activity of Astragalus on immune system has been investigated, the effect of CAG on activated lymphocytes is poorly understood. OBJECTIVE: We aimed to biologically address the possible anti-inflammation potential of CAG on concanavalin A (Con A)-mediated mouse lymphocyte pan-activation model. MATERIALS AND METHODS: Mouse lymphocytes were obtained from spleens and subjected to Con A for 24 h...
June 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28290727/the-toxic-effects-of-benzo-a-pyrene-on-activated-mouse-t-cells-in-vitro
#20
Shuang Guan, Yixuan Huang, Zhe Feng, Linli Xu, Yingli Jin, Jing Lu
Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon contaminant that is widely present in environmental sources, including food. This study aims to clarify the effects of B[a]P toxicity on activated mouse T cells in vitro. Our results show that B[a]P markedly inhibited Concanavalin A (ConA)-induced T lymphocyte proliferation and suppressed the production of the cytokines Interferon (IFN)-γ, Interleukin (IL)-2 and IL-4. Western blot and protein-DNA interaction assays were used to study how B[a]P affects signal transduction...
June 2017: Immunopharmacology and Immunotoxicology
journal
journal
29720
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"