Margaret Quaid, Jaclyn M Goodrich, Miriam M Calkins, Judith M Graber, Derek Urwin, Jamie Gabriel, Alberto J Caban-Martinez, Rebekah L Petroff, Casey Grant, Shawn C Beitel, Sally Littau, John J Gulotta, Darin Wallentine, Jeff Hughes, Jefferey L Burgess
Prostate cancer is the leading incident cancer among men in the United States. Firefighters are diagnosed with this disease at a rate 1.21 times higher than the average population. This increased risk may result from occupational exposures to many toxicants, including per- and polyfluoroalkyl substances (PFAS). This study assessed the association between firefighting as an occupation in general or PFAS serum levels, with DNA methylation. Only genomic regions previously linked to prostate cancer risk were selected for analysis: GSTP1, Alu repetitive elements, and the 8q24 chromosomal region...
March 24, 2024: Environmental and Molecular Mutagenesis