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Environmental and Molecular Mutagenesis

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https://www.readbyqxmd.com/read/29761935/the-application-of-transcriptional-benchmark-dose-modeling-for-deriving-thresholds-of-effects-associated-with-solar-simulated-ultraviolet-radiation-exposure
#1
Sami S Qutob, Vinita Chauhan, Byron Kuo, Andrew Williams, Carole L Yauk, James P McNamee, B Gollapudi
Considerable data has been generated to elucidate the transcriptional response of cells to ultraviolet radiation (UVR) exposure providing a mechanistic understanding of UVR-induced cellular responses. However, using these data to support standards development has been challenging. In this study, we apply benchmark dose (BMD) modeling of transcriptional data to derive thresholds of gene responsiveness following exposure to solar-simulated UVR. Human epidermal keratinocytes were exposed to three doses (10, 20, 150 kJ/m2 ) of solar simulated UVR and assessed for gene expression changes 6 and 24 hr postexposure...
May 15, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29761929/assessment-of-polycyclic-aromatic-hydrocarbon-exposure-lung-function-systemic-inflammation-and-genotoxicity-in-peripheral-blood-mononuclear-cells-from-firefighters-before-and-after-a-work-shift
#2
Maria Helena Guerra Andersen, Anne Thoustrup Saber, Julie Elbaek Pedersen, Peter Bøgh Pedersen, Per Axel Clausen, Mille Løhr, Ali Kermanizadeh, Steffen Loft, Niels E Ebbehøj, Åse Marie Hansen, Ismo Kalevi Koponen, Eva-Carina Nørskov, Ulla Vogel, Peter Møller
Firefighting is regarded as possibly carcinogenic, although there are few mechanistic studies on genotoxicity in humans. We investigated exposure to polycyclic aromatic hydrocarbons (PAH), lung function, systemic inflammation and genotoxicity in peripheral blood mononuclear cells (PBMC) of 22 professional firefighters before and after a 24-h work shift. Exposure was assessed by measurements of particulate matter (PM), PAH levels on skin, urinary 1-hydroxypyrene (1-OHP) and self-reported participation in fire extinguishing activities...
May 15, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29761860/hypermethylation-of-cpg-islands-is-associated-with-increasing-chromosomal-damage-in-chinese-lead-exposed-workers
#3
Li-Bo Yu, Yu-Ting Tu, Jing-Wen Huang, Ya-Nan Zhang, Guo-Qiao Zheng, Xiao-Wen Xu, Jin-Wei Wang, Jean Qin Xiao, David C Christiani, Zhao-Lin Xia
Lead is a widely existing environmental pollutant with potential carcinogenicity. To investigate the association of blood lead level (B-Pb) with potential chromosomal damage and cancer, we analyzed micronucleus (MN) frequency of peripheral blood lymphocytes (PBLs) and the methylation status of six human tumor suppressor genes (TSGs) post lead exposure. In the study, 147 lead-exposed workers were divided into two groups according to their B-Pb P50 value, with other 50 lead-unexposed workers as a control group...
May 15, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29761828/differential-micronucleus-frequency-in-isogenic-human-cells-deficient-in-dna-repair-pathways-is-a-valuable-indicator-for-evaluating-genotoxic-agents-and-their-genotoxic-mechanisms
#4
Liton Kumar Saha, Sujin Kim, Habyeong Kang, Salma Akter, Kyungho Choi, Tetsushi Sakuma, Takashi Yamamoto, Hiroyuki Sasanuma, Kouji Hirota, Jun Nakamura, Masamitsu Honma, Shunichi Takeda, S Dertinger
The micronucleus (MN) test has become an attractive tool both for evaluating the genotoxicity of test chemicals because of its ability to detect clastogenic and aneugenic events and for its convenience. As the MN assay has been mostly performed using only DNA repair-proficient mammalian cells, we believed that the comparison of the MN frequency between DNA repair-proficient and -deficient human cells may be an excellent indicator for detecting the genotoxic potential of test chemicals and for understanding their mode of action...
May 15, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29668064/assessment-of-a-panel-of-cellular-biomarkers-and-the-kinetics-of-their-induction-in-comparing-genotoxic-modes-of-action-in-hepg2-cells
#5
Benjamin Kopp, Morgane Dario, Daniel Zalko, Marc Audebert
One major challenge for in vitro genotoxicology is the determination of the genotoxic mode of action of tested compounds. The quantification of the phosphorylation of the histones H3 (pH3) and H2AX (γH2AX) allows an efficient discrimination between aneugenic and clastogenic compounds. However, these two biomarkers do not permit to deduct the specific mechanisms involved in the action of clastogenic compounds. The aim of this study was to investigate other possible cellular biomarkers allowing differentiating clastogenic properties...
April 18, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29668047/miniaturization-of-the-microsuspension-salmonella-microsome-assay-in-agar-microplates
#6
José Ricardo R M Zwarg, Daniel A Morales, Bianca S Maselli, Werner Brack, Gisela A Umbuzeiro
The Salmonella/microsome assay (Ames test) is the most widely used mutagenicity test for the evaluation of pure chemicals and environmental samples. There are several versions of protocols available in the literature, including those that reduce the amount of sample needed for testing with liquid and agar media. The microsuspension version of the Salmonella/microsome assay is more sensitive than the standard protocol. It is performed using 5-times concentrated bacteria and less sample and S9 mixture, but still uses conventional Petri dishes (90 × 15 mm)...
April 18, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29668046/black-cohosh-extracts-and-powders-induce-micronuclei-a-biomarker-of-genetic-damage-in-human-cells
#7
Stephanie L Smith-Roe, Carol D Swartz, Kim G Shepard, Steven M Bryce, Stephen D Dertinger, Suramya Waidyanatha, Grace E Kissling, Scott S Auerbach, Kristine L Witt
Black cohosh extract (BCE) is a widely used dietary supplement marketed to women to alleviate symptoms of gynecological ailments, yet its toxicity has not been well characterized. The National Toxicology Program (NTP) previously reported significant increases in micronucleated erythrocytes in peripheral blood of female Wistar Han rats and B6C3F1/N mice administered 15-1,000 mg BCE/kg/day by gavage for 90 days. These animals also developed a dose-dependent nonregenerative macrocytic anemia characterized by clinical changes consistent with megaloblastic anemia...
April 18, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29668043/folate-deficiency-increases-chromosomal-damage-and-mutations-in-hematopoietic-cells-in-the-transgenic-mutamouse-model
#8
Danielle P LeBlanc, Nathalie A Behan, Jason M O'Brien, Francesco Marchetti, Amanda J MacFarlane
Folate deficiency causes megaloblastic anemia and neural tube defects, and is also associated with some cancers. In vitro, folate deficiency increases mutation frequency and genome instability, as well as exacerbates the mutagenic potential of known environmental mutagens. Conversely, it remains unclear whether or not elevated folic acid (FA) intakes are beneficial or detrimental to the induction of DNA mutations and by proxy human health. We used the MutaMouse transgenic model to examine the in vivo effects of FA deficient, control, and supplemented diets on somatic DNA mutant frequency (MF) and genome instability in hematopoietic cells...
April 18, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29656392/epigenetic-modifications-preserve-the-hyperaccumulator-noccaea-caerulescens-from-ni-geno-toxicity
#9
Mariolina Gullì, Laura Marchi, Rosaria Fragni, Annamaria Buschini, Giovanna Visioli
The Ni hyperaccumulator Noccaea caerulescens has adapted to live in a naturally stressed environment, evolving a complex pattern of traits to cope with adverse conditions. Evidence is accumulating regarding the important role of epigenetic modifications in regulating plant responses to stress. In this study, we present data from the natural "open-field" adaptation of the Ni hyperaccumulator N. caerulescens to serpentine soil and provide the first evidence of the involvement of epigenetic changes in response to the high Ni content present in plant leaves...
April 15, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29637621/assessment-of-sediment-mutagenicity-in-areas-under-the-influence-of-a-contaminated-site-undergoing-a-remediation-process
#10
Paula Hauber Gameiro, Naiara Costa Pereira, Jocelita Aparecida Vaz Rocha, Karen Alam Leal, Vera Maria Ferrão Vargas
Soil contamination enters aquatic ecosystems affecting sediment quality. The region studied is the Taquari River, Brazil, close to a site contaminated by wood preservatives, with a runoff route into the river. The first stage of the remediation process (In this article, the terms intervention and remediation have been used with slightly different meanings. We consider intervention to be the first phase of the remediation process, which aims to remove active sources) was an intervention to remove the main active sources...
April 10, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29602275/study-of-the-effects-of-0-15-terahertz-radiation-on-genome-integrity-of-adult-fibroblasts
#11
Valeria Franchini, Stefania De Sanctis, Jessica Marinaccio, Andrea De Amicis, Elisa Coluzzi, Sara Di Cristofaro, Florigio Lista, Elisa Regalbuto, Andrea Doria, Emilio Giovenale, Gian Piero Gallerano, Roberto Bei, Monica Benvenuto, Laura Masuelli, Ion Udroiu, Antonella Sgura
The applications of Terahertz (THz) technologies have significantly developed in recent years, and the complete understanding of the biological effects of exposure to THz radiation is becoming increasingly important. In a previous study, we found that THz radiation induced genomic damage in fetal fibroblasts. Although these cells demonstrated to be a useful model, exposure of human foetuses to THz radiation is highly improbable. Conversely, THz irradiation of adult dermal tissues is cause of possible concern for some professional and nonprofessional categories...
March 30, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29602183/gene-expression-profiling-in-healthy-newborns-from-diverse-localities-of-the-czech-republic
#12
Katerina Honkova, Andrea Rossnerova, Jitka Pavlikova, Vlasta Svecova, Jiri Klema, Jan Topinka, Alena Milcova, Helena Libalova, Hyunok Choi, Milos Veleminsky, Radim J Sram, Pavel Rossner
Prenatal exposure to air pollution is associated with intrauterine growth restriction and low birth weight. Gene expression changes in newborns in relation to air pollution have not been sufficiently studied. We analyzed whole genome expression in cord blood leukocytes of 202 newborns from diverse localities of the Czech Republic, differing among other factors in levels of air pollution: the district of Karvina (characterized by higher concentration of air pollutants) and Ceske Budejovice (lower air pollution levels)...
March 30, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29569274/the-effects-of-acetaldehyde-exposure-on-histone-modifications-and-chromatin-structure-in-human-lung-bronchial-epithelial-cells
#13
Danqi Chen, Lei Fang, Hongjie Li, Chunyuan Jin
As the primary metabolite of alcohol and the most abundant carcinogen in tobacco smoke, acetaldehyde is linked to a number of human diseases associated with chronic alcohol consumption and smoking including cancers. In addition to direct DNA damage as a result of the formation of acetaldehyde-DNA adducts, acetaldehyde may also indirectly impact proper genome function through the formation of protein adducts. Histone proteins are the major component of the chromatin. Post-translational histone modifications (PTMs) are critically important for the maintenance of genetic and epigenetic stability...
March 22, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29569272/anti-genotoxic-longevity-inductive-cytotoxic-and-clastogenic-related-bioactivities-of-tomato-andlycopene
#14
Zahira Fernández-Bedmar, Jaouad Anter, Ángeles Alonso Moraga
The aim of this study was to evaluate some biological activities of tomato as well as lycopene and to consider a new nutraceutic value for this fruit regarding to the protection against genetic damage and as a chemopreventive agent. Genotoxicity, DNA-protection against hydrogen peroxide, and lifespan properties of tomato and lycopene were assessed through wing spot test and longevity assay using the Drosophila in vivo model. Additionally, chemopreventive activity was investigated through cytotoxicity, DNA-fragmentation comet and annexin V FITC/PI assays using HL60 in vitro model...
March 22, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29569270/effect-of-nutritional-status-on-arsenic-and-smokeless-tobacco-induced-genotoxicity-sperm-abnormality-and-oxidative-stress-in-mice-in-vivo
#15
Samrat Das, Pimily Langthasa, Dharmeswar Barhoi, Puja Upadhaya, Sarbani Giri
BACKGROUND: Recently, high concentrations of arsenic have been documented in ground waters of Southern Assam, India. Indiscriminate smokeless tobacco consumption is a common practice in this region. Correlation between nutritional status and arsenic and smokeless tobacco-induced health effects has not been taken up in humans or other test systems. METHODS: Mice were divided into groups based on protein (casein) content in the diet: High protein (40%), optimum protein (20%), and low protein (5%)...
March 22, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29536588/single-nucleotide-mtdna-polymorphisms-may-contribute-to-cancerogenesis-in-mitochondrial-disorders
#16
LETTER
Josef Finsterer, Sinda Zarrouk-Mahjoub
No abstract text is available yet for this article.
March 14, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29536566/reply
#17
LETTER
Neal Sondheimer, Brett Kaufman, Martin Picard
No abstract text is available yet for this article.
March 14, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29536573/application-of-the-cometchip-platform-to-assess-dna-damage-in-field-collected-blood-samples-from-turtles
#18
Peter Sykora, Ylenia Chiari, Andrew Heaton, Nickolas Moreno, Scott Glaberman, Robert W Sobol
DNA damage has been linked to genomic instability and the progressive breakdown of cellular and organismal homeostasis, leading to the onset of disease and reduced longevity. Insults to DNA from endogenous sources include base deamination, base hydrolysis, base alkylation, and metabolism-induced oxidative damage that can lead to single-strand and double-strand DNA breaks. Alternatively, exposure to environmental pollutants, radiation or ultra-violet light, can also contribute to exogenously derived DNA damage...
May 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29481708/2-hydroxypyridine-n-oxide-hopo-equivocal-in-the-ames-assay
#19
Krista L Dobo, Jennifer R Cheung, William C Gunther, Michelle O Kenyon
2-Hydroxypyridine-N-oxide (HOPO) is a useful coupling reagent for synthesis of active pharmaceutical ingredients. It has been reported to be weakly mutagenic in the Ames assay (Ding W et al. []: J Chromatogr A 1386:47-52). According to the ICH M7 guidance (2014) regarding control of mutagenic impurities to limit potential carcinogenic risk, mutagens require control in drug substances such that exposure not exceeds the threshold of toxicological concern. Given the weak response observed in the Ames assay and the lack of any obvious structural features that could confer DNA reactivity we were interested to determine if the results were reproducible and investigate the role of potentially confounding experimental parameters...
May 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29481700/conventional-and-novel-omics-based-approaches-to-the-study-of-carbon-nanotubes-pulmonary-toxicity
#20
REVIEW
Célia Ventura, António Sousa-Uva, João Lavinha, Maria João Silva
The widespread application of carbon nanotubes (CNT) on industrial, biomedical, and consumer products can represent an emerging respiratory occupational hazard. Particularly, their similarity with the fiber-like shape of asbestos have raised a strong concern about their carcinogenic potential. Several in vitro and in vivo studies have been supporting this view by pointing to immunotoxic, cytotoxic and genotoxic effects of some CNT that may conduct to pulmonary inflammation, fibrosis, and bronchioloalveolar hyperplasia in rodents...
May 2018: Environmental and Molecular Mutagenesis
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