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Korean Journal of Internal Medicine

Sulhattin Arslan, Gürsel Yildiz, Levent Özdemir, Erdal Kaysoydu, Bülent Özdemir
Background/Aims: Many systems including the cardiovascular system (ischemic heart diseases, heart failure, and hypertension) may act as comorbidities that can be seen during the course of chronic obstructive pulmonary disease (COPD). Comorbidities affect the severity and prognosis of COPD negatively. Nearly 25% of patients with COPD die due to cardiovascular diseases. In this study, we aimed to evaluate the relationship between the blood pressure, inflammation, hypoxia, hypercapnia, and the severity of airway obstruction...
November 16, 2018: Korean Journal of Internal Medicine
Jin-Seok Park, Seok Jeong, Joon Mee Kim, Bum Hei Lee, Jae Min Kim, Don Haeng Lee
Background/Aims: A reproducible, endoscope-based, large animal model, of acute pancreatitis was developed to meet the need for a suitable means of preclinically testing treatments. The aim of this study was to develop an endoscope-based animal model of acute pancreatitis. Methods: This experimental study was conducted on six mini-pigs. The pancreatitis model was induced by infusing contrast medium (CM) or sodium taurocholate (TCA) under high pressure (100 mmHg) into the main pancreatic duct by endoscopic retrograde pancreatography...
November 16, 2018: Korean Journal of Internal Medicine
Shin Hye Yoo, Chan-Young Ock, Bhumsuk Keam, Sung Joon Park, Tae Min Kim, Jin Ho Kim, Yoon Kyung Jeon, Eun-Jae Chung, Seong Keun Kwon, J Hun Hah, Tack-Kyun Kwon, Kyeong Chun Jung, Dong-Wan Kim, Hong-Gyun Wu, Myung-Whun Sung, Dae Seog Heo
Background/Aims: Since patients with human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have favorable outcomes after treatment, treatment de-escalation for these patients is being actively investigated. However, not all HPV-positive HNSCCs are curable, and some patients have a poor prognosis. The purpose of this study was to identify poor prognostic factors in patients with HPV-positive HNSCC. Methods: Patients who received a diagnosis of HNSCC and tested positive for HPV from 2000 to 2015 at a single hospital site (n = 152) were included in this retrospective analysis...
November 16, 2018: Korean Journal of Internal Medicine
Jae Hwang Cha, Jin Seok Jang
Background/Aims: The relationship between the serum pepsinogen (sPG) level and changes in gastric mucosa has been well studied. Here, we evaluated the usefulness of sPG (I, II, I/II ratio) and intragastric pH as a biomarker of severe gastric atrophy in gastric neoplastic lesions. Methods: A total of 186 consecutive Korean patients with gastric neoplastic lesions underwent endoscopic submucosal dissection (ESD) in this study. The serologic atrophy group had sPG I level ≤ 70 ng/mL and an sPG I/II ratio ≤ 3...
November 7, 2018: Korean Journal of Internal Medicine
Sule Tas Gulen, Ufuk Eryilmaz, Mustafa Yilmaz, Fisun Karadag
Background/Aims: Most important cause of mortality in chronic obstructive pulmonary disease (COPD) patients is known to be cardiovascular disease (CVD). The objective of the present study was to evaluate the echocardiographic parameters in COPD patients with or without pre-diagnosed CVD and to investigate the relationship between echocardiographic parameters and systemic inflammation markers. Methods: A total of 60 stable COPD patients (23 patients with CVD, group 1; 37 patients without CVD, group 2) and 21 healthy controls (group 3) were included in the study...
October 29, 2018: Korean Journal of Internal Medicine
Jin Niang Nan, Ok Ran Kim, Myung Ah Lee
Background/Aims: This study was tried to determine the role of β-catenin in invasion in pancreatic cancer. Methods: We analyzed cancer invasiveness according to β-catenin expression in pancreatic cancer cell line. We also investigated the change in cancer invasiveness when β-catenin expression was changed. To enhance β-catenin activity, we treated low β-catenin cancer cell line, PANC1, with Wnt-3a conditioned media and transected β-catenin. We also treated high β-catenin expressing cell line, BxPC3, with XAV939, β-catenin inhibitor and siRNA for β-catenin to inhibit β-catenin expression...
October 26, 2018: Korean Journal of Internal Medicine
Hyunseok Cho, Jae-Woo Kwon
Background/Aims: Despite the clinical importance anaphylaxis and the recent increase in its occurrence, studies regarding the epidemiology of anaphylaxis, risk factors for anaphylaxis, and epinephrine auto-injector (EAI) prescription status for patients with anaphylaxis remain poorly described. Thus, we investigated the prevalence of anaphylaxis and prescription rates of EAI in urban and rural areas in Korea. Methods: We used data from the 2010 to 2014 Health Insurance Review and Assessment database...
October 26, 2018: Korean Journal of Internal Medicine
Se Ryeon Lee, Hojoon Choi, Byung Hyun Lee, Ka-Won Kang, Eun Sang Yu, Dae Sik Kim, Yong Park, Chul Won Choi, Byung Soo Kim, Hwa Jung Sung
Background/Aims: Bortezomib plus melphalan-prednisone (VMP) is a standard treatment for multiple myeloma, particularly for patients who are ineligible for high-dose therapy. However, early discontinuation or treatment modification is often needed owing to adverse events. The aim of this study was to investigate the clinical outcomes of modifying the dose of melphalan-prednisone (MP) in patients receiving VMP. Methods: We examined 67 patients who received a modified dose of MP, and 38 patients who received the regularly planned dose of MP...
October 26, 2018: Korean Journal of Internal Medicine
Young Jin Youn, Juyong Lee
Chronic venous insufficiency (CVI) of the lower extremities manifests itself in various clinical spectrums, ranging from asymptomatic but cosmetic problems to severe symptoms, such as venous ulcer. CVI is a relatively common medical problem but is often overlooked by healthcare providers because of an underappreciation of the magnitude and impact of the problem, as well as incomplete recognition of the various presenting manifestations of primary and secondary venous disorders. The prevalence of CVI in South Korea is expected to increase, given the possible underdiagnoses of CVI, the increase in obesity and an aging population...
October 26, 2018: Korean Journal of Internal Medicine
Jee-Min Kim, Deog Kyeom Kim
No abstract text is available yet for this article.
October 26, 2018: Korean Journal of Internal Medicine
Hyera Kim, Kang Kook Lee, Mi Hwa Heo, Jin Young Kim
Background/Aims: The occurrence of brain metastasis (BM) has increased due to improved overall survival (OS) in uterine cervical cancer. However, research about prognostic factors and therapeutic guidelines for BM in uterine cervical cancer remains scarce due to the rarity of BM in this type of cancer. The present study evaluated the clinical characteristics and prognostic factors influencing OS in patients with BM from uterine cervical cancer. Methods: A total of 19 BM patients of uterine cervical cancer were analyzed retrospectively from January 1995 to December 2016...
October 26, 2018: Korean Journal of Internal Medicine
Min Young Baek, Jeong-Ju Yoo, Soung Won Jeong, Jae Young Jang, Yong Kwon Kim, Shin Ok Jeong, Sae Hwan Lee, Sang Gyune Kim, Sang-Woo Cha, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Boo Sung Kim, Yong Jae Kim, Su Yeon Park
Background/Aims: Transarterial chemoembolization (TACE) is performed for single hepatocellular carcinoma (HCC) that are not eligible for surgery or ablation therapy. We investigated the clinical outcomes of patients with a single HCC ≤ 5 cm treated with TACE. Methods: This study analyzed 175 consecutive patients who underwent TACE as an initial treatment for single HCC ≤ 5 cm. Predictive factors for complete response (CR), recurrence after CR, and overall survival (OS) were evaluated...
October 26, 2018: Korean Journal of Internal Medicine
Joo Hee Lee, Min Joo Jeon, Joon Seon Song, Eun Jin Chae, Jin-Ho Choi, Gu-Hwan Kim, Jin Woo Song
Background/Aims: Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant disorder that is characterized by skin fibrofolliculomas, pulmonary cysts, and renal tumors. The objective of this study was to describe the features of Korean patients with BHD syndrome. Methods: Clinical data were retrospectively reviewed in 12 patients (10 confirmed by direct sequencing of the folliculin (FLCN) gene and two confirmed by clinical diagnosis) diagnosed from 2004 to 2016 at Asan Medical Center, Seoul, South Korea...
October 26, 2018: Korean Journal of Internal Medicine
Hong Jun Kim, Suk-Young Lee, Dae Sik Kim, Eun Joo Kang, Jung Sun Kim, Yoon Ji Choi, Sang Cheul Oh, Jae Hong Seo, Jun Suk Kim
Background/Aims: Patients with pancreatic cancer (PC) generally have poor clinical outcomes. Early determination of their prognosis is crucial for developing a therapeutic strategy. Recently, various inflammatory markers have been validated as prognostic indicators for many cancers, including PC. However, few studies have evaluated these markers together. Thus, the purpose of this study was to comprehensively evaluate the value of inflammatory markers as prognostic indicators in patients with advanced PC treated with gemcitabine-based chemotherapy as the first line regimen...
October 26, 2018: Korean Journal of Internal Medicine
Hee Jin Son, Nayoung Kim, Chin-Hee Song, Sun Min Lee, Ha-Na Lee, Young-Joon Surh
Background/Aims: Estrogen is known to have protective effect in colorectal cancer development. The aims of this study are to investigate whether estradiol treatment reduces inflammation in CCD841CoN, a female human colonic epithelial cell line and to uncover underlying mechanisms of estradiol effects. Methods: 17β-Estradiol (E2) effect was measured by Western blot after inducing inf lammation of CCD841CoN by tumor necrosis factor α (TNF-α). Expression levels of estrogen receptor α (ERα) and β (ERβ), cyclooxygenase-2 (COX-2), nuclear factor-κB (NF-κB), heme oxygenase-1 (HO-1), and NAD(P)H-quinone oxidoreductase-1 (NQO-1) were also evaluated...
October 22, 2018: Korean Journal of Internal Medicine
Ki Hong Choi, Ga Yeon Lee, Jin-Oh Choi, Eun-Seok Jeon, Hae-Young Lee, Sang Eun Lee, Jae-Joong Kim, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Myeong-Chan Cho, Hyun-Young Park, Byung-Hee Oh
Background/Aims: It is unknown whether different β-blockers (BBs) have variable effects on long-term survival of patients with heart failure with reduced ejection fraction (HFrEF). This study compares the effects of two BBs, carvedilol and bisoprolol, on survival in patients with HFrEF. Methods: The Korean Acute Heart Failure (KorAHF) registry is a prospective multicenter cohort that includes 5,625 patients who were hospitalized for acute heart failure (AHF). We selected 3,016 patients with HFrEF and divided this study population into two groups: BB at discharge (n = 1,707) or no BB at discharge (n = 1,309)...
October 16, 2018: Korean Journal of Internal Medicine
Seung Yong Park, Keum Ha Choi, Hyung Ku Chon
No abstract text is available yet for this article.
October 16, 2018: Korean Journal of Internal Medicine
In Hee Lee, Byung Woog Kang, Jong Gwang Kim, Woo Kyun Bae, Myung Seo Ki, Inkeun Park, Jae-Cheol Jo, Jin Young Kim, Sung Ae Koh, Kyung Hee Lee, Yoon Young Cho, Hun Mo Ryoo, Sang Gyu Kwak, Jung Lim Lee, Sun Ah Lee
Background/Aims: For metastatic renal cell carcinoma (RCC), various prognostic scoring systems have been developed. However, owing to the low prevalence of nonclear cell RCC, the three most commonly used tools were mainly developed based on patients with clear cell histology. Accordingly, this study applied three prognostic models to Korean non-clear cell RCC patients treated with first-line temsirolimus. Methods: This study analyzed data for 74 patients with non-clear cell RCC who were treated with temsirolimus as the first-line therapy at eight medical centers between 2011 and 2016...
October 12, 2018: Korean Journal of Internal Medicine
Jun Sik Yoon, Sang Jik Lee, Eun Soo Kim, Sung Kook Kim, Min Kyu Jung, Hyun Seok Lee, Yong Hwan Kwon, Su Youn Nam, Seong Woo Jeon, Sun Jin, Joon Seop Lee, Seong Jae Yeo
Background/Aims: The Internet is the main resource for health-related information. The incidence of inflammatory bowel disease (IBD) is rapidly increasing in Asian countries. However, the quality of websites for IBD available in this region has not been evaluated. We aimed to evaluate the quality of the information on IBD obtained from Korean websites. Methods: Using the terms "Crohn's disease" or "ulcerative colitis," websites were selected from those obtained with the three most renowned search engines in Korea; 60 websites from the results of each engine were chosen...
October 1, 2018: Korean Journal of Internal Medicine
Bongyoung Kim, Hyeonjun Hwang, Jieun Kim, Myoung-Jae Lee, Hyunjoo Pai
Background/Aims: This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea. Methods: This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each class of antibiotic was converted to defined daily dose (DDD)/1,000 patient-days. We defined 3rd generation cephalosporins, 4th generation cephalosporins, β-lactam/β-lactamase inhibitors, and fluoroquinolones as broad-spectrum antibiotics; carbapenems, tigecycline, glycopeptides, oxazolidinone, and polymyxin were defined as antibiotics against multidrug-resistant (MDR) pathogens...
September 27, 2018: Korean Journal of Internal Medicine
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