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Korean Journal of Internal Medicine

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https://www.readbyqxmd.com/read/29338140/primary-pyomyositis-in-north-india-a-clinical-microbiological-and-outcome-study
#1
Susheel Kumar, Ashish Bhalla, Rajveer Singh, Navneet Sharma, Aman Sharma, Vikas Gautam, Surjit Singh, Subhash Varma
Background/Aims: Pyomyositis is an infective condition with primary involvement of the skeletal muscles. There is sparse recent literature on patients with pyomyositis. Methods: This study was carried out at emergency services of a tertiary care center located in subtropical area of Indian subcontinent. Results: Sixty-two patients of primary pyomyositis formed the study cohort. Mean age of occurrence was 29.9 ± 14.8 years. There were 54 men...
January 18, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29334724/disparity-in-crohn-s-disease-activity-between-home-and-clinics-is-associated-with-unscheduled-hospital-visits-due-to-disease-flares
#2
Eun Soo Kim, Yoo Jin Lee, Byung Ik Jang, Kyeong Ok Kim, Eun Young Kim, Hyun Seok Lee, Seong Woo Jeon, Sang Gyu Kwak
Background/Aims: E-health technologies have been implemented for the management of Crohn's disease (CD). We aimed to identify differences between patient activities at home and at routine clinic visits using a web-based self-reporting CD symptom diary (CDSD) and to determine the impact of this disparity on clinical outcomes. Methods: Patients with CD from three tertiary hospitals were invited to assess their symptoms at least once a week using CDSD. We identified patients who showed disparities in disease activity (high activity at home but normal at the next hospital visit) and evaluated clinical outcomes of these patients such as unscheduled visits due to flares using Kaplan-Meier analyses...
January 17, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29334723/methacholine-bronchial-provocation-test-in-patients-with-asthma-serial-measurements-and-clinical-significance
#3
Hyun-Jung Seo, Pureun-Haneul Lee, Byeong-Gon Kim, Sun-Hye Lee, Jong-Sook Park, Junehyuck Lee, Sung-Woo Park, Do-Jin Kim, Choon-Sik Park, An-Soo Jang
Background/Aims: The methacholine bronchial provocation test (MBPT) is used to detect and quantify airway hyper-responsiveness (AHR). Since improvements in the severity of asthma are associated with improvements in AHR, clinical studies of asthma therapies routinely use the change of airway responsiveness as an objective outcome. The aim of this study was to assess the relationship between serial MBPT and clinical profiles in patients with asthma. Methods: A total of 323 asthma patients were included in this study...
January 17, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29334722/comparison-of-the-morphologic-criteria-recist-and-metabolic-criteria-eortc-and-percist-in-tumor-response-assessments-a-pooled-analysis
#4
Hong Deok Kim, Bum Jun Kim, Hyeong Su Kim, Jung Han Kim
Background/Aims: The Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) or European Organization for Research and Treatment of Cancer (EORTC) criteria are used to assess metabolic tumor responses. However, tumor responses have shown considerable discrepancies between the morphologic criteria (Response Evaluation Criteria in Solid Tumors [RECIST]) and metabolic criteria. We performed this pooled study to compare the RECIST and metabolic criteria in the assessment of tumor responses...
January 17, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29334721/efficacy-and-safety-of-tocilizumab-in-korean-patients-with-active-rheumatoid-arthritis
#5
Han Joo Baek, Mie Jin Lim, Won Park, Sung Hwan Park, Seung-Cheol Shim, Dae-Hyun Yoo, Hyun Ah Kim, Soo Kon Lee, Yun Jong Lee, Young Eun Park, Hoon-Suk Cha, Yeong-Wook Song
Background/Aims: To investigate the efficacy and safety of tocilizumab (TCZ) humanized anti-interleukin-6 receptor monoclonal antibody, in Korean patients with active rheumatoid arthritis (RA) refractory to conventional disease modifying anti-rheumatic drugs (DMARDs) including methotrexate (MTX). Methods: The main study was a 24-week, randomized, double-blind, controlled trial that was followed by a 48-week, open-labeled, extension phase. TCZ (8 mg/kg) or placebo was intravenously administered every 4 weeks...
January 17, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29320847/new-insights-into-the-role-of-renal-resident-cells-in-the-pathogenesis-of-lupus-nephritis
#6
Seung-Ki Kwok, George C Tsokos
Systemic lupus erythematosus (SLE), an autoimmune disease of unknown etiology, is characterized by the production of autoantibodies and end-organ damage. Lupus nephritis affects up to 70% of patients with SLE and is the most critical predictor of morbidity and mortality. The immunopathogenesis of SLE is complex and most clinical trials of biologics targeting immune cells or their mediators have failed to show efficacy in SLE patients. It has therefore become increasingly clear that additional, local factors give rise to the inflammation and organ damage...
January 12, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29295613/ciliary-metaplasia-in-a-patient-with-antineutrophil-cytoplasmic-autoantibody-associated-pauci-immune-glomerulonephritis
#7
Chang-Hoon Lee, Jin Han Lim, Kyoung Min Kim, Moon Hyang Park, Kyung Pyo Kang
No abstract text is available yet for this article.
January 8, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29295612/the-effect-of-the-dexamethasone-cytarabine-and-cisplatin-dhap-regimen-on-stem-cell-mobilization-and-transplant-outcomes-of-patients-with-non-hodgkin-s-lymphoma-who-are-candidates-for-up-front-autologous-stem-cell-transplantation
#8
So Yeon Jeon, Ho-Young Yhim, Hee Sun Kim, Jeong-A Kim, Deok-Hwan Yang, Jae-Yong Kwak
Background/Aims: Data on dexamethasone, cytarabine, and cisplatin (DHAP) as a mobilization regimen, compared to high-dose cyclophosphamide (HDC), for up-front autologous stem cell transplantation (ASCT) in non-Hodgkin's lymphoma (NHL) is limited. Methods: Consecutive patients with aggressive NHL treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or rituximab-CHOP who underwent chemomobilization using HDC or DHAP plus granulocyte-colony stimulating factor (G-CSF) for up-front ASCT were enrolled from three institutions between 2004 and 2014...
January 8, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29294602/sclerosing-mesenteritis-mimicking-mesenteric-malignancy
#9
Jung Yeop Lee, Ki Jung Yun, Dong Baek Kang, Tae Hyeon Kim, Hyung Ku Chon
No abstract text is available yet for this article.
January 5, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29294601/iatrogenic-huge-intracardiac-air-embolism-during-chest-computed-tomography
#10
Seunghoon Cho, Hancheol Lee, Sanghoon Shin, Jong-Kwan Park, Se-Jung Yoon
No abstract text is available yet for this article.
January 5, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29294600/rapid-changes-in-capillary-morphology-and-architecture-in-a-patient-with-dermatomyositis
#11
Sung-Jo Park, In-Ho Choi, Hyun-Sook Kim
No abstract text is available yet for this article.
January 5, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29294599/transarterial-embolization-for-incorrectable-abdominal-wall-hematoma-after-abdominal-paracentesis
#12
Seong Nam Moon
No abstract text is available yet for this article.
January 5, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29294598/rapid-onset-of-efficacy-predicts-response-to-therapy-with-certolizumab-plus-methotrexate-in-patients-with-active-rheumatoid-arthritis
#13
Young Mo Kang, Young-Eun Park, Won Park, Jung-Yoon Choe, Chul-Soo Cho, Seung-Cheol Shim, Sang Cheol Bae, Chang-Hee Suh, Hoon-Suk Cha, Eun Mi Koh, Yeong-Wook Song, Bin Yoo, Shin-Seok Lee, Min-Chan Park, Sang-Heon Lee, Catherine Arendt, Willem Koetse, Soo-Kon Lee
Background/Aims: The objective of this study was to determine the efficacy and safety of add-on therapy with certolizumab pegol (CZP) in active rheumatoid arthritis (RA) patients of a single ethnicity. Methods: In this 24-week, phase 3, randomized, double-blind, placebo-controlled trial, eligible patients (n = 127) were randomized 2:1 to subcutaneous CZP + methotrexate (MTX; 400 mg at week 0, 2, and 4 followed by 200 mg every 2 weeks) or placebo + MTX. Results: At week 24, the American College of Rheumatology criteria for 20% (ACR20) response rate was significantly greater with CZP + MTX than with placebo (66...
January 5, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29294597/microrna-16-inhibits-cell-proliferation-and-migration-by-targeting-heat-shock-protein-70-in-heat-denatured-dermal-fibroblasts
#14
Chun Zhang, Jinhua Dai, Youfen Fan, Xianghui He, Renxiong Wei
Background/Aims: This study aimed to investigate the precise mechanism and function of miR-16 in heat-denatured primary human dermal fibroblasts. Methods: Primary human dermal fibroblasts were separated from normal human skin samples. Under heat stress, the levels of miR-16 and heat shock protein 70 (HSP70) were detected in primary human dermal fibroblasts by quantitative real-time polymerase chain reaction (qRT-PCR). Next, heat-denatured cells were transfected with synthetic scrambled negative control (NC) RNA (NC group), miR-16 mimics, miR-16 inhibitor or miR-16 inhibitor accompanied by small interfering RNA targeting HSP70, then the mRNA level of HSP70 was detected by qRT-PCR, cell proliferation was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and AlamarBlue assay, cell migration was examined by Transwell assay and cell apoptosis was assessed by transferase dUTP (deoxyuridine triphosphate) nick end labeling (TUNEL) assay...
January 5, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29294596/clinical-features-and-prognoses-of-acute-transverse-myelitis-in-patients-with-systemic-lupus-erythematosus
#15
Soo Min Ahn, Seokchan Hong, Doo-Ho Lim, Byeongzu Ghang, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo
Background/Aims: Acute transverse myelitis (ATM) is a severe complication of systemic lupus erythematosus (SLE). This study evaluated the clinical factors related to outcome in patients with SLE-associated ATM. Methods: The medical records of patients diagnosed with SLE-associated ATM between January 1995 and January 2015 were reviewed. The patients were divided into two groups based on improvement of neurological deficits after treatment: favorable response group and unfavorable response group...
January 5, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29294595/should-asymptomatic-young-men-with-iron-deficiency-anemia-necessarily-undergo-endoscopy
#16
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Background/Aims: There has been no evidence for the necessity of endoscopy in asymptomatic young men with iron deficiency anemia (IDA). To determine whether endoscopy should be recommended in asymptomatic young men with IDA, we compared the prevalence of gastrointestinal (GI) lesions between young men (< 50 years) with IDA and those without IDA. Methods: We conducted a case-control study on asymptomatic young men aged < 50 years who underwent both esophagogastroduodenoscopy (EGD) and colonoscopy as part of a health checkup between 2010 and 2014...
January 5, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29277097/systemic-review-agreement-between-the-latent-tuberculosis-screening-tests-among-patients-with-rheumatic-diseases
#17
Junhee Pyo, Soo-Kyung Cho, Dam Kim, Yoon-Kyoung Sung
Background/Aims: To estimate the level of agreement and positivity rates of latent tuberculosis infection (LTBI) tests prior to the use of tumor necrosis factor (TNF) inhibitors in relation to underlying rheumatic diseases and endemic tuberculosis levels. Methods: The Ovid-Medline, Embase, and Cochrane Libraries were searched for articles before October 2013 involving LTBI screening in rheumatic patients, including rheumatoid arthritis (RA), ankylosing spondylitis (AS), juvenile idiopathic arthritis (JIA), and psoriatic arthritis...
December 28, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29277096/an-overview-of-meta-analysis-for-clinicians
#18
Young Ho Lee
The number of medical studies being published is increasing exponentially, and clinicians must routinely process large amounts of new information. Moreover, the results of individual studies are often insufficient to provide confident answers, as their results are not consistently reproducible. A meta-analysis is a statistical method for combining the results of different studies on the same topic and it may resolve conflicts among studies. Meta-analysis is being used increasingly and plays an important role in medical research...
December 28, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29277095/management-and-educational-status-of-adult-anaphylaxis-patients-at-emergency-department
#19
Mi-Yeong Kim, Chan Sun Park, Jae-Won Jeong
Background/Aims: We evaluated the management and educational status of adult anaphylaxis patients at emergency departments (EDs). Methods: Anaphylaxis patients who visited ED from 2011 to 2013 were enrolled from three hospitals. We analyzed clinical features, prior history of anaphylaxis, management and provided education for etiology and/or prevention. For analyzing associated factors with epinephrine injection, Pearson chi-square test was used by SPSS version 21 (IBM Co...
December 28, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29241303/body-fluid-status-assessment-by-bio-impedance-analysis-in-patients-presenting-to-the-emergency-department-with-dyspnea
#20
Chan Soon Park, Sang-Eun Lee, Hyun-Jai Cho, Yong-Jin Kim, Hyun-Jae Kang, Byung-Hee Oh, Hae-Young Lee
Background/Aims: Fluid retention occurs in patients with heart failure, accounting for dyspnea. We investigated the diagnostic implication of body fluid status, assessed by bio-impedance analysis (BIA), in acute heart failure (AHF) among patients who presented with dyspnea. Methods: A total of 100 patients who presented with dyspnea and suspected with AHF were analyzed in this study. We enrolled 50 AHF and 50 non-AHF patients discriminated through echocardiographic analysis and Framingham criteria and were matched by age and sex...
December 18, 2017: Korean Journal of Internal Medicine
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