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Korean Journal of Internal Medicine

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https://www.readbyqxmd.com/read/28103435/negative-pathology-after-endoscopic-resection-of-gastric-epithelial-neoplasms-importance-of-pit-dysplasia
#1
Joon Hyung Jhi, Gwang Ha Kim, Ahrong Kim, Young-Geum Kim, Cheong Su Hwang, Sojeong Lee, Bong Eun Lee, Geun Am Song, Do Youn Park
Background/Aims: Endoscopic resection (ER) is a well-established treatment modality for gastric epithelial neoplasm. However, there is a discrepancy between forceps biopsy and ER specimen pathology, including a negative pathologic diagnosis (NPD) after ER. It has been suggested that pit dysplasia (PD) is a subtype of gastric dysplasia, and the aim of this study was to assess the significance of PD in cases with NPD after ER for early gastric neoplasms. Methods: After ER, 29 NPD lesions that had an associated pretreatment forceps biopsy specimen, were correctly targeted during ER, and had no cautery artifact on the resected specimen were included in this study...
January 20, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28103434/analgesic-effect-of-quetiapine-in-a-mouse-model-of-cancer-induced-bone-pain
#2
Mi Hwa Heo, Jin Young Kim, Ilseon Hwang, Eunyoung Ha, Keon Uk Park
Background/Aims: Cancer-induced bone pain (CIBP) is one of the most common pains in patients with advanced neoplasms. Because of treatment-associated side effects, more than half of cancer patients are reported to have inadequate and undermanaged pain control. New mechanism-based therapies must be developed to reduce cancer pain. Quetiapine is a commonly used atypical antipsychotic drug. We report a study of the potential analgesic effects of quetiapine in a mouse model of CIBP and examine the mechanism of bone pain by analyzing the expression of various nociceptors...
January 20, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28103433/baseline-extent-of-damage-predicts-spinal-radiographic-progression-in-korean-patients-with-ankylosing-spondylitis-treated-with-golimumab
#3
Jeong Seok Lee, Yeong Wook Song, Tae Hwan Kim, Won Tae Jung, Seung Geun Lee, Sung Hwan Park, Gwan Gyu Song, Dae Young Yu, Stephen Xu, Eun Young Lee
Background/Aims: For patients with ankylosing spondylitis (AS), golimumab has consistent efficacy in controlling disease activity over 5 years but its benefit in preventing radiographic progression was less clear at 4 years. To predict radiographic progression, we analyzed the baseline characteristics of AS patients in a Korean population. Methods: Sixty-eight Korean patients with AS participated in the phase 3, multicenter, randomized, placebo-controlled, double-blind trial (GO-RAISE) which has previously been described...
January 20, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28092702/multiple-metastasis-of-follicular-variant-of-papillary-thyroid-carcinoma-coexistent-with-malignant-melanoma
#4
Yu Ji Kim, Kyung Ae Lee, Tae Sun Park, Hong Sun Baek, Heung Yong Jin
No abstract text is available yet for this article.
January 16, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28092701/hypogonadotrophic-hypogonadism-due-to-a-mutation-in-the-luteinizing-hormone-%C3%AE-subunit-gene
#5
Jae Won Song, Hyo-Jeong Hwang, Chang Min Lee, Gun Ha Park, Chul Sik Kim, Seong Jin Lee, Sung-Hee Ihm
No abstract text is available yet for this article.
January 16, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28092700/association-between-thyroid-autoimmunity-and-helicobacter-pylori-infection
#6
Yun Mi Choi, Tae Yong Kim, Eui Young Kim, Eun Kyung Jang, Min Ji Jeon, Won Gu Kim, Young Kee Shong, Won Bae Kim
Background/Aims: There have been controversial reports linking Helicobacter pylori infection to autoimmune thyroid disease (AITD). However, data regarding the relationship are limited for Asian populations, which have an extremely high prevalence of H. pylori infection. We performed this study to investigate the association between H. pylori infection and AITD in Koreans. Methods: This study involved adults aged 30 to 70 years who had visited a health promotion center...
January 16, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28092699/infection-of-human-intestinal-epithelial-cells-by-invasive-bacteria-activates-nf-%C3%AE%C2%BAb-and-increases-icam-1-expression-through-nod1
#7
Woon Geon Shin, Bum Joon Park, Sung Joong Lee, Jae Gyu Kim
Background/Aims: Nucleotide-binding oligomerization domain 1 (NOD1) is required for primary intestinal epithelial cells (IECs) to respond to natural mucopeptides secreted by gram-negative bacteria. Infection of human IECs with invasive bacteria up-regulates intercellular adhesion molecule-1 (ICAM-1) expression. However, the role of NOD family members in host defense has been largely unknown. The aim of this study was to determine whether there is a functional role for NOD1 in the up-regulation of ICAM-1 expression in invasive bacteria-infected IECs...
January 16, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28073242/clinical-phenotypes-of-korean-patients-with-behcet-disease-according-to-gender-age-at-onset-and-hla-b51
#8
Hee Jung Ryu, Mi Ryoung Seo, Hyo Jin Choi, Han Joo Baek
Background/Aims: The clinical manifestations of Behcet disease (BD) have been reported to differ according to country, region, and race. Gender, onset age, and human leukocyte antigen (HLA)-B51 have also been known as the factors that influence the clinical features of BD. The aim of this study is to investigate the clinical phenotypes of Korean patients who visited the rheumatology clinic with BD with respect to gender, onset age, and HLA-B51. Methods: Total 193 Korean patients (129 females and 64 males) fulfilling the international criteria for BD were retrospectively assessed...
January 12, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28073241/prognostic-value-of-total-triiodothyronine-and-free-thyroxine-levels-for-the-heart-failure-in-patients-with-acute-myocardial-infarction
#9
Min Gyu Kang, Jong Ryeal Hahm, Kye-Hwan Kim, Hyun-Woong Park, Jin-Sin Koh, Seok-Jae Hwang, Jin-Yong Hwang, Jong Hwa Ahn, Yongwhi Park, Young-Hoon Jeong, Jeong Rang Park, Choong Hwan Kwak
Background/Aims: Although a low triiodothyronine (T3) state is closely associated with heart failure (HF), it is uncertain whether total T3 levels on admission is correlated with the clinical outcomes of acute myocardial infarction (AMI). The aim of this study is to investigate the prognostic value of total T3 levels for major adverse cardiovascular and cerebrovascular events (MACCEs) in patients with AMI undergone percutaneous coronary intervention (PCI). Methods: A total of 765 PCI-treated AMI patients (65...
January 11, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28063416/nontuberculous-mycobacterial-infection-in-rheumatoid-arthritis-patients-a-single-center-experience-in-south-korea
#10
Doo-Ho Lim, Yong-Gil Kim, Tae Sun Shim, Kyung-Wook Jo, Byeongzu Ghang, Soo Min Ahn, Seokchan Hong, Chang-Keun Lee, Bin Yoo
Background/Aims: Nontuberculous mycobacteria (NTM) infection has been increasing worldwide in both general population and immunocompromised patients, which has also been reported in rheumatoid arthritis (RA) patients. This study aimed to identify the incidence and clinical characteristics of NTM infection in RA patients living in tuberculosis (TB) infection endemic area. Methods: We performed a retrospective analysis of NTM infection cases in our RA registry at a tertiary referral center from January 1995 to December 2013...
January 6, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28063415/efficacy-of-preoperative-percutaneous-cholecystostomy-in-the-management-of-acute-cholecystitis-according-to-severity-grades
#11
Seong Yeol Kim, Kyo-Sang Yoo
Background/Aims: The aim of this retrospective study was to assess the efficacy of percutaneous cholecystostomy (PC) for patients with acute cholecystitis (AC) according to severity. Methods: A total of 325 patients who underwent cholecystectomy between January 2008 and October 2010 were enrolled. Patients were classified into three groups based on severity grade according to the Tokyo guidelines for AC: grade I (mild), grade II (moderate), and grade III (severe)...
January 6, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28063414/atypical-bone-change-of-spine-caused-by-epidural-venous-thrombosis-in-systemic-lupus-erythematosus-with-antiphospholipid-syndrome
#12
Ji Young Kim, Seunghun Lee, Yun Young Choi, Sang-Cheol Bae
No abstract text is available yet for this article.
January 6, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28063418/focal-segmental-glomerulosclerosis-in-atypical-polycystic-kidney-disease
#13
Eun Hui Bae, Hyunsuk Kim, Sung Sun Kim, Seong Kwon Ma, Soo Wan Kim
No abstract text is available yet for this article.
January 5, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28063417/spontaneous-regression-of-cardiac-sarcoidosis-resulting-in-total-occlusion-of-coronary-artery-and-ventricular-aneurysm
#14
Seok Jong Ryu, Yong Kook Hong, Sanghoon Shin, Sungjun Cho, Se-Jung Yoon
No abstract text is available yet for this article.
January 5, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28049213/dystrophic-calcification-after-palliative-chemotherapy-in-a-patient-with-renal-cell-carcinoma
#15
Do Hyoung Lim, Soon Il Lee, Keon Woo Park
No abstract text is available yet for this article.
January 3, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27992711/left-ventricular-thrombi-after-simultaneous-thrombotic-occlusions-of-multiple-coronary-arteries-presenting-acute-myocardial-infarction-need-anticoagulant
#16
Hyun Joong Kim, Kyung Jin Choe, Woo-Dae Bang, Sang Jin Ha, Sang-Yong Yoo, Sangsig Cheong
No abstract text is available yet for this article.
December 20, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27951626/diagnostic-role-of-mean-platelet-volume-and-neutrophil-to-lymphocyte-ratio-in-childhood-brucellosis
#17
Şefika Elmas Bozdemir, Yasemin Ay Altıntop, Salih Uytun, Humeyra Aslaner, Yasemin Altuner Torun
Background/Aims: Brucellosis patients present various non-specific clinical symptoms, such as fever, fatigue, sweating, joint pain, arthritis, myalgia, and headache. Based on the nonspecifity of its clinical signs and symtoms, we decided to evaluate whether mean platelet volume (MPV) , neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) will contribute to the diagnosis. Methods: In this retrospective study, we reviewed hospital-records of 60 children with a confirmed diagnosis of brucellosis in Kayseri between January 2013 and January 2016, and compared the hematological parameters; white blood cell (WBC) count, hemoglobin (Hb), neutrophil count, lymphocyte count, platelet count, MPV, NLR, and PLR with 55 healthy age and gender matched children...
December 14, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27951623/clinical-significance-of-positive-pneumocystis-jirovecii-polymerase-chain-reaction-in-non-human-immunodeficiency-virus-immunocompromised-patients-in-a-real-practice
#18
Hea Yon Lee, Hye Seon Kang, Hwa Young Lee, Chin Kook Rhee, Sook Young Lee, Seok Chan Kim, Seung Joon Kim, Yeon Joon Park, Young Kyoon Kim, Ji Young Kang
Background/Aims: Pneumocystis jirovecii polymerase chain reaction (PCR) can be helpful in diagnosing Pneumocystis pneumonia (PCP); however it has limitations. We evaluated the prevalence of positive P. jirovecii PCR from non-human immunodeficiency virus (HIV) immunocompromised patients and tried to determine the risk of PCP development. Methods: Between May 2009 and September 2012, P. jirovecii PCR was performed in bronchoscopic specimens from 1,231 adult non-HIV immunocompromised patients suspected of respiratory infection...
December 13, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27951621/qualitative-and-quantitative-results-of-interferon-%C3%AE-release-assays-for-monitoring-the-response-to-anti-tuberculosis-treatment
#19
I-Nae Park, Tae Sun Shim
Background/Aims: The usefulness of interferon-γ release assays (IGRAs) in monitoring to responses to anti-tuberculosis (TB) treatment is controversial. We compared the results of two IGRAs before and after anti-TB treatment in same patients with active TB. Methods: From a retrospective review, we selected patients with active TB who underwent repeated QuantiFERON-TB Gold (QFN-Gold, Cellestis Limited) and T-SPOT.TB (Oxford Immunotec) assays before and after anti-TB treatment with first-line drugs...
December 13, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27951622/analysis-of-computed-tomographic-findings-according-to-gastroesophageal-flap-valve-grade
#20
Hye Kyung Jeon, Gwang Ha Kim, Nam Kyung Lee, Suk Kim, Bong Eun Lee, Geun Am Song
Background/Aims: The gastroesophageal junction is an important barrier against gastroesophageal ref lux. Endoscopic grading of gastroesophageal f lap valve is simple, reproducible, and may predict reflux activity. We investigated the correlation between gastroesophageal flap valve grade and the gastroesophageal junction's structural properties using abdominal computed tomography. Methods: A total of 138 patients with early gastric cancer who underwent both pre-treatment esophagogastroduodenoscopy and water-distended stomach two-phase computed tomography were enrolled...
December 12, 2016: Korean Journal of Internal Medicine
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