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Korean Journal of Internal Medicine

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https://www.readbyqxmd.com/read/28899085/correlation-between-nadph-oxidase-mediated-oxidative-stress-and-dysfunction-of-endothelial-progenitor-cell-in-hyperlipidemic-patients
#1
Ting-Bo Li, Yin-Zhuang Zhang, Wei-Qi Liu, Jie-Jie Zhang, Jun Peng, Xiu-Ju Luo, Qi-Lin Ma
Background/Aims: NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (NOX)-mediated oxidative stress plays a key role in promotion of oxidative injury in the cardiovascular system. The aim of this study is to evaluate the status of NOX in endothelial progenitor cells (EPCs) of hyperlipidemic patients and to assess the correlation between NOX activity and the functions EPCs. Methods: A total of 30 hyperlipidemic patients were enrolled for this study and 30 age-matched volunteers with normal level of plasma lipids served as controls...
September 13, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28899084/comparison-of-liquid-based-cytology-cellprepplus-and-conventional-smears-in-pancreaticobiliary-disease
#2
Myeong Ho Yeon, Hee Seok Jeong, Hee Seung Lee, Jong Soon Jang, Seungho Lee, Soon Man Yoon, Hee Bok Chae, Seon Mee Park, Sei Jin Youn, Joung-Ho Han, Hye-Suk Han, Ho Chang Lee
Background/Aims: Endoscopic ultrasound-guided fine needle aspiration (EUSFNA) and brushing cytology are used worldwide to diagnose pancreatic and biliary malignant tumors. Liquid-based cytology (LBC) has been developed and it is currently used to overcome the limitations of conventional smears (CS). In this study, the authors aimed to compare the diagnostic value of the CellPrepPlus (CP; Biodyne) LBC method with CS in samples obtained using EUS-FNA and brushing cytology. Methods: This study prospectively enrolled 75 patients with pancreatic or biliary lesions from June 2012 to October 2013...
September 13, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28882024/higher-glucagon-to-insulin-ratio-is-associated-with-elevated-glycated-hemoglobin-levels-in-type-2-diabetes-patients
#3
Minyoung Lee, Minkyung Kim, Jong Suk Park, Sangbae Lee, Jihong You, Chul Woo Ahn, Kyung Rae Kim, Shinae Kang
Background/Aims: The importance of α-cell dysfunction in the pathogenesis of type 2 diabetes has re-emerged recently. However, data on whether relative glucagon excess is present in clinical settings are scarce. We aimed to investigate associations between glucagon-to-insulin ratio and various metabolic parameters. Methods: A total of 451 patients with type 2 diabetes naïve to insulin treatment were recruited. Using glucagon-to-insulin ratio, we divided subjects into quartiles according to both fasting and postprandial glucagon-to-insulin ratios...
September 8, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28874042/adverse-drug-reaction-monitoring-during-antimicrobial-therapy-for-septicemia-patients-at-a-university-hospital-in-new-delhi
#4
Md Shamshir Alam, Krishna Kolappa Pillai, Syed Aliul Hasan Abdi, Prem Kapur, Paru Kutty Pillai, Kandasamy Nagarajan
Background/Aims: Adverse drug reaction (ADR) is an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product. The present study was conducted in order to monitor the frequency and severity of ADR during antimicrobial therapy of septicemia. Methods: A prospective, observational, and noncomparative study was conducted over a period of 6 months on patients of septicemia admitted at a university hospital. Naranjo algorithm scale was used for causality assessment...
September 6, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28851211/comment-on-clinical-significance-of-changes-in-the-corrected-qt-interval-in-stress-induced-cardiomyopathy
#5
John E Madias
No abstract text is available yet for this article.
August 31, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28844123/use-of-hypnotics-and-the-risk-of-or-mortality-from-heart-disease-a-meta-analysis-of-observational-studies
#6
Young-Hyo Kim, Hong-Bae Kim, Do-Hyoung Kim, Ja-Young Kim, Hyun-Young Shin
Background/Aims: Some observational epidemiologic studies have reported conflicting results on the relationship between hypnotics use and the risk of developing and/or dying from heart disease. We investigated these associations using a meta-analysis of available literatures. Methods: We searched the databases PubMed and EMBASE, along with the bibliographies of relevant articles to find additional publications in February 2016. Results: Of 495 articles satisfying our initial criteria, two case-control studies and six cohort studies met our inclusion criteria and were included in the final analyses...
August 28, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28844122/clinical-significance-of-radiation-induced-liver-disease-after-stereotactic-body-radiation-therapy-for-hepatocellular-carcinoma
#7
Baek Gyu Jun, Young Don Kim, Gab Jin Cheon, Eun Seog Kim, Eunjin Jwa, Sang Gyune Kim, Young Seok Kim, Boo Sung Kim, Soung Won Jeong, Jae Young Jang, Sae Hwan Lee, Hong Soo Kim
Background/Aims: The aim of this study was to investigate parameters that predict radiation-induced liver disease (RILD) following stereotactic body radiotherapy (SBRT) in patients with hepatocellular carcinoma (HCC) and to identify the clinical significance of RILD. Methods: We retrospectively reviewed the medical records of 117 HCC patients who were treated by SBRT from March 2011 to February 2015. RILD was defined as elevated liver transaminases more than five times the upper normal limit or a worsening of Child-Pugh (CP) score by 2 within 3 months after SBRT...
August 28, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28838228/red-blood-cell-distribution-width-is-useful-in-discriminating-adult-onset-still-s-disease-and-sepsis-within-24-hours-after-hospitalization
#8
Hee-Jin Park, Jungsik Song, Yong-Beom Park, Soo-Kon Lee, Sang-Won Lee
Background/Aims: Red blood cell distribution width (RDW) is a value representing the heterogeneity in the size of red blood cell, and it is usually used in distinguishing types of anaemia. Recently, it was reported that it could reflect the burden of inflammation in diverse diseases and their prognosis. Hence, in this study, we investigated whether RDW may contribute to discriminating adult onset Still's disease (AOSD) from sepsis in serious febrile patients within 24 hours after hospitalization...
August 25, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28838227/aromatase-inhibitor-use-is-a-risk-factor-of-carotid-plaque-presence-in-endocrine-responsive-breast-cancer-patients
#9
Da Hea Seo, Yongin Cho, Sujin Lee, Seho Park, Seung-Il Kim, Byeong Woo Park, Yumie Rhee
Background/Aims: The aromatase inhibitors (AIs) are well known anti-hormonal therapy in endocrine-responsive breast cancer patients. It can lead to dyslipidemia and be the risk factor of cardiovascular disease due to low estrogen level. However, some recent studies comparing AIs with placebo have shown controversial results. The aim of this study was to investigate lipid profiles, measurement of carotid intima-media thickness (IMT) and the presence of plaque among endocrine-responsive breast cancer treated with AIs compared to ones that were not treated with AIs...
August 25, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28838226/intradialytic-exercise-improves-physical-function-and-reduces-intradialytic-hypotension-and-depression-in-hemodialysis-patients
#10
So Yon Rhee, Jin Kyung Song, Suk Chul Hong, Jae Won Choi, Hee Jung Jeon, Dong Ho Shin, Eun Hee Ji, Eun-Hee Choi, Jiyeon Lee, Aram Kim, Seung Wook Choi, Jieun Oh
Background/Aims: As numbers of maintenance hemodialysis patients are growing, debilitating conditions of muscle wasting and atrophy are becoming some of the greatest concerns in end-stage renal disease patients. Exercise training has various potential benefits in terms of prevention of a sustained decline in functional status. This study aimed to evaluate the physical, psychological, laboratory, and dialysis-related effects of intradialytic exercise. Methods: We enrolled 22 patients from a hemodialysis center for a 6-month non-randomized prospective trial...
August 25, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28823117/development-of-bronchiolitis-obliterans-organizing-pneumonia-during-standard-treatment-of-hepatitis-c-with-peg-ifn%C3%AE-2b
#11
Eun Chung, Kihoon Park, Jo Heon Kim, Nam Ik Han, Young Sok Lee, Si Hyun Bae, Chung-Hwa Park
No abstract text is available yet for this article.
August 21, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28823116/outcomes-of-living-donor-kidney-transplantation-in-diabetic-patients-age-and-sex-matched-comparison-with-non-diabetic-patients
#12
Chung Hee Baek, Hyosang Kim, Seung Don Baek, Mun Jang, Wonhak Kim, Won Seok Yang, Duck Jong Han, Su-Kil Park
Background/Aims: Kidney transplantation (KT) reportedly provides a significant survival advantage over dialysis in diabetic patients. However, KT outcome in diabetic patients compared with that in non-diabetic patients remains controversial. In addition, owing to recent improvements in the outcomes of KT and management of cardiovascular diseases, it is necessary to analyze outcomes of recently performed KT in diabetic patients. Methods: We reviewed all diabetic patients who received living donor KT between January 2008 and December 2011...
August 21, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28823114/prescription-pattern-of-urate-lowering-therapy-in-korean-gout-patients-data-from-the-national-health-claims-database
#13
Ji-Won Kim, Sang Gyu Kwak, Sung-Hoon Park
No abstract text is available yet for this article.
August 21, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28797159/clinical-implication-of-serum-uric-acid-level-in-pegylated-interferon-and-ribavirin-combination-therapy-for-chronic-hepatitis-c-infection
#14
In Soo Oh, Joung Won Won, Hyung Joon Kim, Hyun Woong Lee
Background/Aims: Combined treatment of pegylated interferon-α (PEG-IFN) and ribavirin (RBV) has long been accepted as the standard treatment for chronic hepatitis C virus (HCV) infection. Many predictive factors for treatment response have been identified. The aim of this study was to evaluate the efficacy and safety of combined PEG-IFN plus RBV and to examine the value of serum uric acid as a predictive factor in the treatment of chronic hepatitis C. Methods: A total of 74 patients chronically infected with HCV were enrolled between December 2004 and June 2009...
August 11, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28724281/the-virtual-asthma-guideline-e-learning-program-learning-effectiveness-and-user-satisfaction
#15
Sung-Yoon Kang, Sae-Hoon Kim, Yong-Eun Kwon, Tae-Bum Kim, Hye-Kyung Park, Heung-Woo Park, Yoon-Seok Chang, Young-Koo Jee, Hee-Bom Moon, Kyung-Up Min, Sang-Heon Cho
Background/Aims: Effective educational tools are important for increasing adherence to asthma guidelines and clinical improvement of asthma patients. We developed a computer-based interactive education program for asthma guideline named the Virtual Learning Center for Asthma Management (VLCAM). We evaluated the usefulness of program in terms of its effects on user awareness of asthma guideline and level of satisfaction. Methods: Physicians-in-training at tertiary hospitals in Korea were enrolled in a cross-sectional questionnaire survey...
July 21, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28859467/transradial-versus-transfemoral-intervention-in-st-segment-elevation-myocardial-infarction-patients-in-korean-population
#16
Hu Li, Seung-Woon Rha, Byoung Geol Choi, Min Suk Shim, Se Yeon Choi, Cheol Ung Choi, Eung Ju Kim, Dong Joo Oh, Byung Ryul Cho, Moo Hyun Kim, Doo-Il Kim, Myung-Ho Jeong, Sang Yong Yoo, Sang-Sik Jeong, Byung Ok Kim, Min Su Hyun, Young-Jin Youn, Junghan Yoon
Background/Aims: Transradial intervention (TRI) is becoming the preferred method over transfemoral intervention (TFI) because TRI is associated with lower incidence of major bleeding and vascular complications. However, there has been limited published data regarding the clinical outcomes of TRI versus TFI in Korean patients with ST-elevation myocardial infarction (STEMI). Methods: A total of 689 consecutive STEMI patients who underwent primary percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) from January to December of 2009 at nine university hospitals were enrolled in this study...
July 7, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28859466/prevalence-of-thyroid-nodules-and-their-associated-clinical-parameters-a-large-scale-multicenter-based-health-checkup-study
#17
Jae Hoon Moon, Min Kyung Hyun, Ja Youn Lee, Jung Im Shim, Tae Hyuk Kim, Hoon Sung Choi, Hwa Young Ahn, Kyung Won Kim, Do Joon Park, Young Joo Park, Ka Hee Yi
Background/Aims: We evaluated the prevalence and characteristics of thyroid nodules detected by thyroid ultrasound (US) at health checkups and the associated clinical parameters. Methods: A total of 72,319 subjects who underwent thyroid US at three health checkup centers in Korea from January 2004 to December 2010 were included in this study. The correlations between the presence of thyroid nodules and other clinical parameters were analyzed. Results: The prevalence of thyroid nodules and cysts was 34...
July 7, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28859468/clinical-and-microbiological-factors-associated-with-early-patient-mortality-from-methicillin-resistant-staphylococcus-aureus-bacteremia
#18
Tark Kim, Yong Pil Chong, Ki-Ho Park, Kyung Mi Bang, Su-Jin Park, Sung-Han Kim, Jin-Yong Jeong, Sang-Oh Lee, Sang-Ho Choi, Jun Hee Woo, Yang Soo Kim
Background/Aims: Methicillin-resistant Staphylococcus aureus bacteremia (MRSAB) is a major bloodstream infection with a high mortality rate. Identification of factors associated with early mortality in MRSAB patients would be useful for predicting prognosis and developing new therapeutic options. Methods: A prospective cohort of MRSAB patients was examined between August 2008 and June 2011. Early and late mortality was defined as death within 2 and 28 days of blood culture, respectively...
July 6, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28651427/loeffler-endocarditis-in-chronic-eosinophilic-leukemia-with-fip1l1-pdgfra-rearrangement-full-recovery-with-low-dose-imatinib
#19
Dae Sik Kim, Sunki Lee, Chul Won Choi
No abstract text is available yet for this article.
June 28, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28859469/histologically-confirmed-nonbacterial-thrombotic-endocarditis-in-a-febrile-leukemic-patient
#20
Eun Gyo Jeong, Mi-Hyang Jung, Ho-Joong Youn
No abstract text is available yet for this article.
June 26, 2017: Korean Journal of Internal Medicine
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