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Korean Journal of Internal Medicine

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https://www.readbyqxmd.com/read/30184615/prognostic-role-of-beclin-1-in-locally-advanced-non-small-cell-lung-cancer-in-patients-receiving-docetaxel-platinum-induction-chemotherapy
#1
Hee Yeon Lee, Jung Ha Shin, Kyo-Young Lee, Jae Kil Park, Sook Whan Sung, Yeon Sil Kim, Jin-Hyoung Kang, Jeong-Oh Kim
Background/Aims: The outcome of local treatment for advanced non-small cell lung cancer (NSCLC) remains poor, with therapies such as induction chemotherapy (IC) yielding conflicting results. This study aimed to assess the clinicopathologic and prognostic significance of the excision repair cross-complementation group 1 (ERCC1), beclin-1, and glucose-regulated protein of molecular mass 78 (GRP78) in patients with locally advanced NSCLC receiving docetaxel-platinum IC, along with efficacy and safety...
September 6, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/30099866/fever-of-unknown-origin-caused-by-intrathyroidal-thymic-carcinoma
#2
Seung Min Chung, Kyung-Ju Kim, Jun Sung Moon, Young Hoon Hong, Su Hwan Kang
No abstract text is available yet for this article.
August 13, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/30099865/cardiac-computed-tomography-reveals-aortic-valve-perforation-in-a-patient-with-severe-aortic-regurgitation
#3
Namkyun Kim, Sung Mok Kim, Sung-Ji Park, Yeon Hyeon Choe
No abstract text is available yet for this article.
August 13, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/30099864/effects-of-botulinum-toxin-injection-on-systemic-sclerosis-related-digital-ulcers
#4
Jin-Woo Souk, Hyun-Sook Kim
No abstract text is available yet for this article.
August 13, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/30099863/jejunal-diverticulosis
#5
Tetsuya Ohira, Atsushi Iraha, Tetsu Kinjo, Akira Hokama, Jiro Fujita
No abstract text is available yet for this article.
August 13, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/30045614/trend-of-multidrug-and-fluoroquinolone-resistance-in-mycobacterium-tuberculosis-isolates-from-2010-to-2014-in-korea-a-multicenter-study
#6
Hyeonseok Kim, Jeong Ha Mok, Bohyoung Kang, Taehoon Lee, Hyun-Kyung Lee, Hang Jea Jang, Yu Ji Cho, Doosoo Jeon
Background/Aims: This study was conducted to evaluate the recent prevalence and trend of anti-tuberculosis (TB) drug resistance with a focus on multidrug-resistance (MDR) and fluoroquinolone resistance in South Korea. Methods: We retrospectively reviewed the drug susceptibility testing results of culture-confirmed Mycobacterium tuberculosis isolates collected from 2010 to 2014 at seven tertiary hospitals in South Korea. Results: A total of 5,599 cases were included: 4,927 (88...
July 27, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/30025442/chilaiditi-syndrome
#7
Ozge Karaman, Muzaffer Kahyaoglu, Emine Alpay, Arzu Kalaycı, Cetin Gecmen
No abstract text is available yet for this article.
July 23, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/30025441/effects-of-aspirin-resistance-and-mean-platelet-volume-on-vascular-access-failure-in-hemodialysis-patients
#8
AJin Cho, Myung Jin Choi, Young-Ki Lee, Han Chae Hoon, Ja-Ryong Koo, Jong-Woo Yoon, Jung-Woo Noh
Background/Aims: Maintaining the patency of vascular access (VA) in hemodialysis (HD) patients is important and can be life-saving. We investigated the effects of aspirin resistance and mean platelet volume (MPV) on VA failure in HD patients. Methods: We enrolled 163 patients on maintenance HD. VA failure was defined as thrombosis or a decrease of > 50% of the normal vessel diameter, as revealed by angiography. Results: Aspirin resistance was observed in 17 of 109 patients in whom this parameter was measured, and was not significantly associated with VA failure (p = 0...
July 23, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29976036/evaluation-of-high-resolution-computed-tomography-findings-of-cystic-fibrosis
#9
Ayse Senay Sasihuseyinoglu, Derya Ufuk Altıntaş, Sureyya Soyupak, Dilek Dogruel, Mustafa Yılmaz, Mahir Serbes, Gulsah Duyuler
Background/Aims: Morphological changes due to lung disease in patients with cystic fibrosis (CF) were evaluated using high resolution computed tomography (HRCT), and the HRCT scores obtained using the Bhalla scoring system were correlated with those obtained using clinical and laboratory indicators. Methods: Medical records of 28 children with CF who underwent chest CT in Department of Pediatric Allergy and Immunology, Cukurova University Balcali Hospital between March 2011 and January 2016 were retrospectively reviewed...
July 6, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29961306/intravascular-imaging-analysis-of-a-drug-eluting-balloon-followed-by-a-bare-metal-stent-compared-to-a-drug-eluting-stent-for-treatment-of-de-novo-lesions
#10
Wonsuk Choi, In-Ho Chae, Jin Joo Park, Sun-Hwa Kim, Si-Hyuck Kang, Il-Young Oh, Chang-Hwan Yoon, Young-Seok Cho, Tae-Jin Youn, Dong-Ju Choi
Background/Aims: After a study comparing drug-eluting stents (DESs) to sequential treatment with drug-eluting balloons (DEBs) and bare metal stents (BMSs), we retrospectively analysed strut malapposition and neointimal hyperplasia in de novo coronary lesions using optical coherence tomography (OCT) or intravascular ultrasonography (IVUS). Methods: We obtained OCT data from 16 patients (eight per group) and IVUS data from 40 patients (20 per group). OCT or IVUS was performed after the index procedure and after 9 months...
July 4, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29950554/clinical-factors-affecting-progression-free-survival-with-crizotinib-in-alk-positive-non-small-cell-lung-cancer
#11
Chan-Young Ock, Shin-Hye Yoo, Bhumsuk Keam, Miso Kim, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung, Dae Seog Heo
Background/Aims: Although crizotinib is standard chemotherapy for advanced anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC), clinical factors affecting progression-free survival (PFS) have not been reported. The purpose of this study was to identify clinical factors affecting PFS of crizotinib and develop a prognostic model for advanced ALK-positive NSCLC. Methods: Clinicopathologic features of patients enrolled in PROFILE 1001, 1005, 1007, and 1014 (training cohort) were reviewed...
June 29, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29936778/atypical-presentation-of-amniotic-fluid-embolism-in-liver-and-colon
#12
Maurizio Zizzo, Maria Cecilia Mengoli, Magda Zanelli, Loredana De Marco, Filippo Lococo, Lara Ugoletti, Claudio Pedrazzoli
No abstract text is available yet for this article.
June 25, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29929349/neuropathic-cancer-pain-prevalence-pathophysiology-and-management
#13
So Young Yoon, Jeeyoung Oh
Neuropathic cancer pain (NCP) is caused by nerve damage attributable to the cancer per se, and/or treatments including chemotherapy, radiotherapy, and surgery; the prevalence is reported to be as high as 40%. The etiologies of NCP include direct nerve invasion or nerve compression by the cancer, neural toxicity, chemotherapy, and radiotherapy. NCP is subdivided into plexopathy, radiculopathy, and peripheral neuropathies, among several other categories. The clinical characteristics of NCP differ from those of nociceptive pain in terms of both the hypersensitivity symptoms (burning, tingling, and an electrical sensation) and the hyposensitivity symptoms (numbness and muscle weakness)...
June 25, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/30180516/the-euphoria-the-warnings-and-the-downfall-of-the-current-bioresorbale-stents-could-the-journey-be-restarted
#14
COMMENT
Nicholas G Kounis, Ioanna Koniari, Emmanouil Chourdakis, Dimitrios Velissaris, George Hahalis
No abstract text is available yet for this article.
September 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/30180515/clinical-usefulness-of-remote-patient-monitoring-using-e-health-technologies-in-patients-with-inflammatory-bowel-diseases
#15
COMMENT
Sung Noh Hong
No abstract text is available yet for this article.
September 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/30045615/immunoglobulin-g4-related-sclerosing-cholangitis
#16
George Goodchild, Stephen P Pereira, George Webster
Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory condition of which IgG4-related sclerosing cholangitis (IgG4-SC) is the biliary manifestation. In this review, we provide an overview of IgG4-RD, with a focus on the biliary manifestations. In particular, we describe the important differential diagnoses of IgG4-SC, namely, primary sclerosing cholangitis and cholangiocarcinoma, outline diagnostic criteria for IgG4-SC, provide insight into possible pathophysiological mechanisms underlying the disease and discuss short and long-term management options of this recently described disease...
September 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29929350/use-of-serology-and-polymerase-chain-reaction-to-detect-atypical-respiratory-pathogens-during-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#17
Chi Young Jung, Yeoung Hun Choe, Sang Yeub Lee, Woo Jin Kim, Jong Deog Lee, Seung Won Ra, Eu Gene Choi, Jae Seung Lee, Myung Jae Park, Ju Ock Na
BACKGROUND/AIMS: To use serological and multiplex polymerase chain reaction (PCR) assays to examine sputum samples from patients experiencing acute exacerbation of chronic obstructive pulmonary disease (AECOPD) for the presence of atypical pathogens, including Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila. METHODS: From September 2012 to February 2014, 341 patients with AECOPD attending outpatient clinics were enrolled as part of a randomized, double-blind, multicenter study...
September 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29921043/genetic-markers-of-severe-cutaneous-adverse-reactions
#18
Jae-Woo Jung, Jae-Yeol Kim, In-Won Park, Byoung-Whui Choi, Hye-Ryun Kang
Adverse drug reactions can cause considerable discomfort. They can be life-threatening in severe cases, requiring or prolonging hospitalization, impeding proper treatment, and increasing treatment costs considerably. Although the incidence of severe cutaneous adverse reactions (SCARs) is low, they can be serious, have permanent sequelae, or lead to death. A recent pharmacogenomic study confirmed that genetic factors can predispose an individual to SCARs. Genetic markers enable not only elucidation of the pathogenesis of SCARs, but also screening of susceptible subjects...
September 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29843491/clinical-significance-of-th17-cells-in-kidney-transplantation
#19
Byung Ha Chung, Chul Woo Yang, Mi-La Cho
Transplantation research has focused on cytotoxic T-cell and plasma cell/B-cell-targeted strategies, but little attention has been paid to the role of T helper 17 (Th17) cells in allograft dysfunction. However, accumulating evidence suggests that Th17 cells contribute to the development of acute and chronic allograft injury after transplantation of various organs, including the kidney. This review summarizes recent reports on the role of Th17 cells in kidney transplantation. Means of improving allograft outcomes by targeting the Th17 pathway are also suggested...
September 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29779362/painful-erythematous-nodules-in-the-left-finger-pads
#20
Jeong Rae Yoo, Sang Taek Heo, Suhyun Oh, Seung-Jae Joo, Ki Yung Boo
No abstract text is available yet for this article.
September 2018: Korean Journal of Internal Medicine
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