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Korean Journal of Internal Medicine

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https://www.readbyqxmd.com/read/28298078/epiphora-following-chemotherapy-with-pemetrexed-in-patients-with-advanced-non-small-cell-lung-cancer
#1
Yun Duk Jung, Sang Bin Lee, Yun Wha Jung, Jung Sub Song, In Sook Woo
No abstract text is available yet for this article.
March 18, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28298077/effects-of-colchicine-on-renal-fibrosis-and-apoptosis-in-obstructed-kidneys
#2
Sejoong Kim, Eun Sook Jung, Jeonghwan Lee, Nam Ju Heo, Ki Young Na, Jin Suk Han
Background/Aims: Colchicine is an established drug for microtubule stabilization that may reduce tissue injury. No data were available that its effects may depend on the dosage of colchicine. We investigated the anti-fibrotic and apoptotic effects of various dose of colchicine in a unilateral ureteral obstruction (UUO) model. Methods: Thirty-six Sprague-Dawley rats were randomly assigned into six groups. Two sham groups were divided into a vehicle-treated or colchicine-treated group (100 μg/kg/day)...
March 18, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28298076/chronic-kidney-disease-in-the-bcr-abl1-negative-myeloproliferative-neoplasm-a-single-center-retrospective-study
#3
Seung-Woo Baek, Ji Young Moon, Hyewon Ryu, Yoon-Seok Choi, Ik-Chan Song, Hyo-Jin Lee, Hwan-Jung Yun, Samyoung Kim, Deog-Yeon Jo
Background/Aims: Renal complications related to BCR-ABL1-negative myeloproliferative neoplasms (MPNs) have not been examined fully in Asian populations. Methods: We analyzed estimated glomerular filtration rate (eGFR) and its changes with time retrospectively in patients with BCR-ABL1-negative MPN from 2005 to 2015. Results: The prevalence of chronic kidney disease (CKD) was 11% (6.6% having stage 3 and 4.4% having stage 4). In a linear regression analysis of eGFR versus time (years), overall, patients showed increased eGFR (mL/min/1...
March 17, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28286937/early-versus-late-bedside-endoscopy-for-gastrointestinal-bleeding-in-critically-ill-patients
#4
Jee Hyun Kim, Ji Hye Kim, Jaeyoung Chun, Changhyun Lee, Jong Pil Im, Joo Sung Kim
Background/Aims: Gastrointestinal (GI) bleeding is a life-threatening complication in critically ill patients. The aim of this study was to determine the efficacy of bedside endoscopy in an intensive care unit (ICU) setting, and to compare the outcomes of early endoscopy (within 24 hours of detecting GI bleeding) with late endoscopy (after 24 hours). Methods: We retrospectively reviewed the medical records of patients who underwent bedside endoscopy for nonvariceal upper GI bleeding and lower GI bleeding that occurred after ICU admission at Seoul National University Hospital from January 2010 to May 2015...
March 15, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28286936/analysis-of-diabetes-quality-assessment-findings-and-future-directions-for-the-appropriate-management-of-diabetes-in-korea
#5
Yu Jin Kim, Suk Chon, Seungjoon Oh, Jeong-Taek Woo, Sung Woon Kim, Sang Youl Rhee
Background/Aims: Due to recent increases in the disease burden of diabetes mellitus, the Health Insurance Review and Assessment Service (HIRA) of Korea implemented a quality assessment of the treatment of diabetes to improve patient care. The present study was conducted to identify any changes after the implementation of the diabetes quality assessment (DQA). Methods: The present study evaluated eight quality assessment indicators that were proposed by the HIRA in all patients with diabetes who visited a university hospital in Korea between 2009 and 2014...
March 15, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28288508/isoniazid-treatment-for-latent-tuberculosis-infection-is-tolerable-for-rheumatoid-arthritis-patients-receiving-tumor-necrosis-factor-inhibitor-therapy
#6
Yoon-Kyoung Sung, Soo-Kyung Cho, Dam Kim, Soyoung Won, Chan-Bum Choi, Tae-Hwan Kim, Jae-Bum Jun, Dae-Hyun Yoo, Sang-Cheol Bae
Background/Aims: To evaluate the impact of isoniazid (INH) treatment for latent tuberculosis infection (LTBI) on the development of liver function test (LFT) abnormality and the persistence of tumor necrosis factor (TNF) inhibitors in rheumatoid arthritis (RA) patients. Methods: We retrospectively enrolled patients with RA who were treated with TNF inhibitors at a university hospital between December 2000 and November 2011. After dividing the patients into two groups based on the occurrence of LFT abnormality during follow-up, we compared demographic and clinical features between the two groups...
March 13, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28286940/comparison-of-tolvaptan-treatment-between-patients-with-the-siadh-and-congestive-heart-failure-a-single-center-experience
#7
Gun Ha Park, Chang Min Lee, Jae Won Song, Moon Chan Jung, Jwa Kyung Kim, Young Rim Song, Hyung Jik Kim, Sung Gyun Kim
Background/Aims: Tolvaptan is a very effective treatment for hypervolemic or euvolemic hyponatremia. We compared the clinical efficacy of and response to tolvaptan in patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and congestive heart failure (CHF). Methods: We retrospectively reviewed the medical records of 50 patients (SIADH, n = 30; CHF, n = 20) who were prescribed tolvaptan between July 2013 and October 2015. Tolvaptan was prescribed when the serum sodium level was < 125 mmol/L and the standard treatment failed...
March 13, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28286939/epidemiological-trend-of-pulmonary-thromboembolism-at-a-tertiary-hospital-in-korea
#8
Tae Yun Park, Jae-Woo Jung, Jae Chol Choi, Jong Wook Shin, Jae Yeol Kim, Byoung Whui Choi, In Won Park
Background/Aims: Despite increasing interest in pulmonary thromboembolism (PTE), data on recent trends in PTE incidence are limited. This study evaluated the recent incidence rate of PTE. Methods: We performed a retrospective chart review of patients with PTE admitted to Chung-Ang University Hospital during the 10-year period from 2006 to 2015. Age-standardized incidence and mortality rates were calculated by the direct method per 100,000 populations. To analyze the trend of risk factor, we also calculated the proportions of cancer, major operation, and recent major fracture over that time...
March 13, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28286938/n-acetyl-l-cysteine-controls-osteoclastogenesis-through-regulating-th17-differentiation-and-rankl-in-rheumatoid-arthritis
#9
Hae-Rim Kim, Kyoung-Woon Kim, Bo-Mi Kim, Kyung-Ann Lee, Sang-Heon Lee
Background/Aims: This study aimed to determine the regulatory role of N-acetyl-l-cysteine (NAC), an antioxidant, in interleukin 17 (IL-17)-induced osteoclast differentiation in rheumatoid arthritis (RA). Methods: After RA synovial fibroblasts were stimulated by IL-17, the expression and production of receptor activator of nuclear factor κ-B ligand (RANKL) was determined by real-time polymerase chain reaction and enzyme-linked immunosorbent assay (ELISA). Osteoclastogenesis was also determined after co-cultures of IL-17-stimulated RA synovial fibroblasts, Th17 cells and various concentrations of NAC with monocytes...
March 13, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28226202/predictors-of-acute-myocarditis-in-complicated-scrub-typhus-an-endemic-province-in-the-republic-of-korea
#10
Jung Yeon Chin, Ki-Woon Kang, Kyung Min Moon, Jongwoo Kim, Yu Jeong Choi
Background/Aims: Scrub typhus is known as a self-limited infectious disease. Cardiac complication is uncommon and usually not life-threatening. Until now, few cases of fulminant myocarditis by scrub typhus have been reported. So, we investigated incidence and predictors of acute myocarditis in severe scrub typhus. Methods: We retrospectively reviewed 89 patients among 91 scrub typhus confirmed patients who examined an echocardiogram and cardiac biomarkers from 2005 to 2015 in the intensive care unit at our hospital...
February 23, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28192890/blocking-junctional-adhesion-molecule-c-promotes-the-recovery-of-cisplatin-induced-acute-kidney-injury
#11
Sun Chul Kim, Yoon Sook Ko, Hee Young Lee, Myung-Gyu Kim, Sang-Kyung Jo, Won-Yong Cho
Background/Aims: Recent findings have demonstrated the occurrence of neutrophil transendothelial migration in the reverse direction (reverse TEM) and that endothelial junctional adhesion molecule C (JAM-C) is a negative regulator of reverse TEM. In this study, we tested the effects of a JAM-C blocking antibody on the resolution of kidney injuries and inflammation in a mouse model of cisplatin-induced acute kidney injury (AKI). Methods: Cisplatin was administered via intraperitoneal injection...
February 15, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28192889/effects-of-aristolochic-acid-i-and-or-hypokalemia-on-tubular-damage-in-c57bl-6-rat-with-aristolochic-acid-nephropathy
#12
Joo-Hark Yi, Sang-Woong Han, Wan-Young Kim, Jin Kim, Moon-Hyang Park
Background/Aims: This study was designed to investigate the roles of aristolochic acid I (AA-I) and hypokalemia in acute aristolochic acid nephropathy (AAN). Methods: After an adaptation period (1 week), a total of 40 C57BL/6 mice (male, 8 weeks old) were divided into four groups: I (control group), II (low potassium [K] diet), III (normal K diet with administration of AA-I [10 mg/kg weight]), and IV (low K diet with AA-I). After collecting 24 hours of urine at 2 weeks, the mice were sacrificed, and their blood and kidneys were obtained to perform immunochemical staining and/or Western blot analysis...
February 15, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28192888/computed-tomography-morphologic-features-of-pulmonary-adenocarcinoma-with-brain-bone-metastasis
#13
Ki-Eun Hwang, Su-Jin Oh, Chul Park, Se-Jeong Jeon, Jeong-Mi Lee, Byong-Ki Cha, Kwon-Ha Yoon, Eun-Taik Jeong, Hak-Ryul Kim
Background/Aims: Brain and bone metastases are common in patients with lung cancer. The development of metastasis is associated with poor survival in lung cancer patients. Although tumor morphologic features on radiographs are routinely assessed for differentiation between benign and malignant lung nodules, they are not used to predict metastasis. We assessed morphologic features of pulmonary adenocarcinomas with brain/bone metastasis on computed tomography (CT) to identify related factors for metastasis...
February 15, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28190327/prevalence-of-and-factors-associated-with-anxiety-and-depression-in-korean-patients-with-newly-diagnosed-advanced-gastrointestinal-cancer
#14
Junghwa Chung, Gawon Ju, Jiyoul Yang, Jiwon Jeong, Yusook Jeong, Moon Ki Choi, Jihyun Kwon, Ki Hyeong Lee, Seung Taik Kim, Hye Sook Han
Background/Aims: The purpose of the present study was to assess the prevalence of and factors associated with anxiety and depression in Korean patients with advanced gastrointestinal cancer. Methods: One hundred and twenty consecutive patients with newly diagnosed, advanced gastrointestinal cancer who were scheduled to receive palliative chemotherapy between July 2012 and June 2014 were enrolled in this observational prospective study. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS) and Patient Health Questionnaire-9 (PHQ-9)...
February 14, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28171716/reference-intervals-of-thyroid-hormones-during-pregnancy-in-korea-an-iodine-replete-area
#15
Hye Jeong Kim, Yoon Young Cho, Sun Wook Kim, Tae Hyuk Kim, Hye Won Jang, Soo-Youn Lee, Suk-Joo Choi, Cheong-Rae Roh, Jong-Hwa Kim, Jae Hoon Chung, Soo-Young Oh
Background/Aims: Maternal thyroid dysfunction has been associated with adverse pregnancy outcomes. The purpose of our study was to establish trimester-specific reference intervals for thyroid hormones in pregnant women in Korea, where iodine intake is more than adequate and to examine pregnancy and perinatal outcomes in their offspring. Methods: Among 459 healthy pregnant women who were screened, we enrolled 417 subjects who had negative results for thyroid autoantibodies...
February 8, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28142231/prevalence-and-risk-factors-for-reduced-pulmonary-function-in-diabetic-patients-the-korea-national-health-and-nutrition-examination-survey
#16
Hee Yeon Kim, Tae Seo Sohn, Hannah Seok, Chang Dong Yeo, Young Soo Kim, Jae Yen Song, Young Bok Lee, Dong-Hee Lee, Jae-Im Lee, Tae-Kyu Lee, Seong Cheol Jeong, Mihee Hong, Hiun Suk Chae
Background/Aims: An association between reduced pulmonary function and diabetes has been observed. Our aim was to evaluate the prevalence and risk factors associated with reduced pulmonary function in diabetic patients. Methods: We analyzed data from the Korea National Health and Nutrition Examination Survey 2011 to 2013. The study population included data from 8,784 participants (including 1,431 diabetics) aged ≥ 40 years. Reduced pulmonary function was defined as patients with restrictive (forced expiratory volume in 1 second/ forced vital capacity [FEV1/FVC] ≥ 0...
February 1, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28142230/compound-k-attenuates-glucose-intolerance-and-hepatic-steatosis-through-ampk-dependent-pathways-in-type-2-diabetic-oletf-rats
#17
Yoo-Cheol Hwang, Da-Hee Oh, Moon Chan Choi, Sang Yeoul Lee, Kyu-Jeong Ahn, Ho-Yeon Chung, Sung-Jig Lim, Sung Hyun Chung, In-Kyung Jeong
Background/Aims: Non-alcoholic fatty liver disease is associated with insulin resistance. Compound K (CK) is the final metabolite of panaxadiol ginsenosides that have been shown to exert antidiabetic effects. However, the molecular mechanism of the antidiabetic effects in the liver have not been elucidated; further, whether CK has beneficial effects in hepatosteatosis remains unclear. Therefore, we evaluated the effect of CK on hepatosteatosis as well as its mechanism in high-fat diet (HFD)-fed type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats...
February 1, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28122420/maternal-and-neonatal-outcomes-in-korean-women-with-type-2-diabetes
#18
Hye-Jung Jang, Hee-Sook Kim, Sung-Hoon Kim
Background/Aims: The purpose of this study was to compare maternal and neonatal outcomes in Korean women with type 2 diabetes and nondiabetic controls. Methods: We performed a retrospective survey of 200 pregnancies in women with type 2 diabetes (n = 100) and nondiabetic controls (n = 100) who delivered from 2003 to 2010 at Cheil General Hospital & Women's Healthcare Center, Korea. We compared maternal characteristics as well as maternal and neonatal outcomes between groups matched by age, pre-pregnancy weight, body mass index, parity, and gestational age at delivery...
January 26, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28111432/comparing-tuberculin-skin-test-and-interferon-%C3%AE-release-assay-t-spot-tb-to-diagnose-latent-tuberculosis-infection-in-household-contacts
#19
Hyun Woo Lee, Yeon Joo Lee, Se Joong Kim, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Choon-Taek Lee, Jae-Ho Lee
Background/Aims: The tuberculin skin test (TST) and interferon γ release assay are currently used as diagnostic tools to detect latent tuberculosis (TB) infection; however, there are inconsistencies about the degree of agreement between the tests. We aimed to evaluate the concordance rate between the two tests in household contacts of a country with intermediate TB burden, where most people were vaccinated. Methods: We recruited household contacts who spent > 8 hours daily with patients with microbiologically confirmed active pulmonary TB, and received both TST and T-SPOT...
January 24, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28111431/initial-titration-with-200-%C3%AE-g-fentanyl-buccal-tablets-a-retrospective-safety-analysis-in-korean-cancer-patients
#20
Mi-Young Kwon, Ha-Na Cho, Dong-Hoe Koo, Yun-Gyoo Lee, Sukjoong Oh, Seung-Sei Lee
Background/Aims: Managing breakthrough pain (BTP) is important for many cancer patients because of the rapid onset and unpredictable nature of the pain episodes. Fentanyl buccal tablets (FBTs) are a rapid-onset opioid indicated for BTP management. However, FBT titration is needed to optimize BTP management. In this study, we aimed to evaluate the safety and efficacy of initiating 200 μg FBTs in Korean cancer patients. Methods: A retrospective analysis of medical records was performed on all advanced cancer patients treated with FBTs for BTP between October 2014 and July 2015...
January 24, 2017: Korean Journal of Internal Medicine
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