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Korean Journal of Internal Medicine

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https://www.readbyqxmd.com/read/28814069/phlegmonous-gastritis-in-an-ankylosing-spondylitis-patient-treated-with-infliximab
#1
Bo Young Kim, Hyun-Sook Kim
No abstract text is available yet for this article.
August 18, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28814068/the-activation-of-nlrp3-inflammsome-by-stimulation-of-diesel-exhaust-particles-in-lung-tissues-from-emphysema-model-and-raw-264-7-cell-line
#2
Soo-Taek Uh, So My Koo, Yangki Kim, Kiup Kim, Sungwoo Park, An Soo Jang, Dojin Kim, Yong Hoon Kim, Choon-Sik Park
Background/Aims: Diesel exhaust particles (DEPs) lead to elevation of reactive oxygen species, which can activate the nucleotide-binding oligomerization domain-like receptor (NLR) family members containing the pyrin domain 3 (NLRP3)-inf lammasome. In this study, we elucidated whether NLRP3 -inf lammasome is activated by DEPs and whether antioxidants (N-acetylcysteine [NAC]) could inhibit such activation. Methods: RAW 264.7 cells and ex vivo lung tissues explants obtained from elastase-induced emphysema animal models were stimulated with cigarette smoking extract (CSE), DEPs, and lipopolysaccharide, and levels of interleukin-1β (IL-1β), caspase-1 and nucleotide-binding oligomerization domain-like receptor (NLR) family members containing the pyrin domain (NLRP3)-inflammasome were assessed by Western blotting and immunohistochemistry...
August 18, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28797161/masked-inherited-primary-arrhythmia-syndromes-in-sudden-cardiac-death-patients-accompanied-by-coronary-vasospasm
#3
Ki Hong Lee, Hyung Wook Park, Jeong Nam Eun, Jeong Gwan Cho, Nam Sik Yoon, Mi Ran Kim, Yo Han Ku, Hyukjin Park, Seung Hun Lee, Jeong Han Kim, Min Chul Kim, Woo Jin Kim, Hyun Kuk Kim, Jae Yeong Cho, Keun-Ho Park, Doo Sun Sim, Hyun Ju Yoon, Kye Hun Kim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jong Chun Park
Background/Aims: Coronary vasospasms are one of the important causes of sudden cardiac death (SCD). Provocation of coronary vasospasms can be useful, though some results may lead to false positives, with patients potentially experiencing recurrent SCD despite appropriate medical treatments. We hypothesized that it is not coronary vasospasms but inherited primary arrhythmia syndromes (IPAS) that underlie the development of SCD. Methods: We analyzed 74 consecutive patients (3...
August 11, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28797160/ileocolonoscopic-findings-in-patients-with-ankylosing-spondylitis-a-single-center-retrospective-study
#4
Soo Min Ahn, Yong-Gil Kim, Seung-Hyeon Bae, Doo-Ho Lim, Seokchan Hong, Sang Hyoung Park, Chang-Keun Lee, Bin Yoo
Background/Aims: In some Western countries, up to 50% of patients with ankylosing spondylitis (AS) have subclinical gut inflammation. This study was conducted to evaluate the prevalence and severity of gut inflammation and to determine clinical factors associated with colonic inflammation in Korean AS patients who performed ileocolonoscopy without evidence of established inf lammatory bowel diseases before. Methods: One hundred and eight AS patients who underwent ileocolonoscopy were included in this study...
August 11, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28797159/clinical-implication-of-serum-uric-acid-level-in-pegylated-interferon-and-ribavirin-combination-therapy-for-chronic-hepatitis-c-infection
#5
In Soo Oh, Joung Won Won, Hyung Joon Kim, Hyun Woong Lee
Background/Aims: Combined treatment of pegylated interferon-α (PEG-IFN) and ribavirin (RBV) has long been accepted as the standard treatment for chronic hepatitis C virus (HCV) infection. Many predictive factors for treatment response have been identified. The aim of this study was to evaluate the efficacy and safety of combined PEG-IFN plus RBV and to examine the value of serum uric acid as a predictive factor in the treatment of chronic hepatitis C. Methods: A total of 74 patients chronically infected with HCV were enrolled between December 2004 and June 2009...
August 11, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28797158/comment-on-gastric-cancer-and-family-history
#6
Amin Talebi Bezmin Abadi
No abstract text is available yet for this article.
August 11, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28750502/geographic-and-demographic-variabilities-of-quantitative-parameters-in-stress-myocardial-computed-tomography-perfusion
#7
Jinoh Park, Hyun-Sook Kim, Hye Jeon Hwang, Dong Hyun Yang, Hyun Jung Koo, Joon-Won Kang, Young-Hak Kim
Background/Aims: To evaluate the geographic and demographic variabilities of the quantitative parameters of computed tomography perfusion (CTP) of the left ventricular (LV) myocardium in patients with normal coronary artery on computed tomography angiography (CTA). Methods: From a multicenter CTP registry of stress and static computed tomography, we retrospectively recruited 113 patients (mean age, 60 years; 57 men) without perfusion defect on visual assessment and minimal (< 20% of diameter stenosis) or no coronary artery disease on CTA...
July 28, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28724281/the-virtual-asthma-guideline-e-learning-program-learning-effectiveness-and-user-satisfaction
#8
Sung-Yoon Kang, Sae-Hoon Kim, Yong-Eun Kwon, Tae-Bum Kim, Hye-Kyung Park, Heung-Woo Park, Yoon-Seok Chang, Young-Koo Jee, Hee-Bom Moon, Kyung-Up Min, Sang-Heon Cho
Background/Aims: Effective educational tools are important for increasing adherence to asthma guidelines and clinical improvement of asthma patients. We developed a computer-based interactive education program for asthma guideline named the Virtual Learning Center for Asthma Management (VLCAM). We evaluated the usefulness of program in terms of its effects on user awareness of asthma guideline and level of satisfaction. Methods: Physicians-in-training at tertiary hospitals in Korea were enrolled in a cross-sectional questionnaire survey...
July 21, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28651427/loeffler-endocarditis-in-chronic-eosinophilic-leukemia-with-fip1l1-pdgfra-rearrangement-full-recovery-with-low-dose-imatinib
#9
Dae Sik Kim, Sunki Lee, Chul Won Choi
No abstract text is available yet for this article.
June 28, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28602061/factors-associated-with-low-level-physical-activity-in-elderly-patients-with-chronic-obstructive-pulmonary-disease
#10
Sang Hee Lee, Ki Uk Kim, Haejung Lee, Yun Seong Kim, Min Ki Lee, Hye-Kyung Park
Background/Aims: In patients with chronic obstructive pulmonary disease (COPD), the extent of physical activity (PA) is correlated with disease severity and prognosis. However, factors associated with low-level PA in elderly COPD patients are not known. We assessed the levels of PA and clinical factors associated with low-level of PA in elderly COPD patients. Methods: This was a secondary analysis of a multicenter, prospective study of 245 patients with COPD. Among them, 160 patients with 65 years or more were included...
June 7, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28602060/diagnostic-accuracy-of-manual-office-blood-pressure-measurement-in-ambulatory-hypertensive-patients-in-korea
#11
Sehun Kim, Jin Joo Park, Seung-Ah Lee, Youngjin Cho, Yeonyee E Yoon, Il-Young Oh, Chang-Hwan Yoon, Jung-Won Suh, Young-Seok Cho, Tae-Jin Youn, Goo-Yeong Cho, In-Ho Chae, Hae-Young Lee, Jinho Shin, Sungha Park, Dong-Ju Choi
Background/Aims: Currently, office blood pressure (OBP) is the most widely used method of measuring blood pressure (BP) in daily clinical practice. However, data on the diagnostic accuracy of OBP in reference to ambulatory blood pressure (ABP) are scarce in Korea. Methods: In retrospective and prospective cohorts, manual OBP and ABP measurements were compared among ambulatory hypertensive patients. Hypertension was defined as systolic OBP ≥ 140 mmHg and/or diastolic OBP ≥ 90 mmHg, and systolic ABP ≥ 130 mmHg and/or diastolic ABP ≥ 80 mmHg...
June 7, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28602059/depth-and-combined-infection-is-important-predictor-of-lower-extremity-amputations-in-hospitalized-diabetic-foot-ulcer-patients
#12
Eun-Gyo Jeong, Sung Shim Cho, Sang-Hoon Lee, Kang-Min Lee, Seo-Kyung Woo, Yoongoo Kang, Jae-Seung Yun, Seon-Ah Cha, Yoon-Jung Kim, Yu-Bae Ahn, Seung-Hyun Ko, Jung-Min Lee
Background/Aims: As the prevalence of diabetes mellitus and its complications increase rapidly, diabetic foot ulcers (DFUs), which are a major diabetic complication, are expected to increase. For prevention and effective treatment, it is important to understand the clinical course of DFUs. The aim of this study was to investigate the natural course and predictors of amputation in patients with DFUs who required hospitalization. Methods: A total of 209 patients with type 2 diabetes, aged 30 to 85 years, who visited emergency department or needed hospitalization due to DFUs were consecutively enrolled from May 2012 to January 2016, by retrospective medical record review...
June 7, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28602063/risk-factors-for-poor-prognosis-in-nosocomial-infective-endocarditis
#13
Ji-Won Hwang, Seung Woo Park, Eun Jeong Cho, Ga Yeon Lee, Eun Kyoung Kim, Sung-A Chang, Sung-Ji Park, Sang-Chol Lee, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song
Background/Aims: The aim of our study was to compare the characteristics of nosocomial infective endocarditis (NIE) with community-acquired infective endocarditis (CIE) and to determine independent risk factors for in-hospital death. Methods: We retrospectively reviewed the medical records of 560 patients diagnosed with infective endocarditis. NIE was defined by a diagnosis made > 72 hours after hospital admission or within 2 months of hospital discharge. Results: Among the 560 cases reviewed, 121 were classified as NIE...
June 2, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28560862/low-serum-bilirubin-level-predicts-the-development-of-chronic-kidney-disease-in-patients-with-type-2-diabetes-mellitus
#14
Kang Hee Ahn, Sang Soo Kim, Won Jin Kim, Jong Ho Kim, Yun Jeong Nam, Su Bin Park, Yun Kyung Jeon, Bo Hyun Kim, In Joo Kim, Yong Ki Kim
Background/Aims: We evaluated whether serum bilirubin levels can predict the development of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM). Methods: This was a retrospective observational longitudinal study of patients presenting at the Pusan National University Hospital. A total of 349 patients with T2DM and preserved kidney function (estimated glomerular filtration rate ≥ 60 mL/min/1.73 m2) were enrolled. The main outcome was the development of CKD stage 3 or greater...
May 31, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28602064/notch-signaling-in-the-collecting-duct-regulates-renal-tubulointerstitial-fibrosis-induced-by-unilateral-ureteral-obstruction-in-mice
#15
Arum Choi, Sun Ah Nam, Wan-Young Kim, Sang Hee Park, Hyang Kim, Chul Woo Yang, Jin Kim, Yong Kyun Kim
Background/Aims: Mind bomb-1 (Mib1) encodes an E3 ubiquitin ligase, which is required for the initiation of Notch signaling. Recently, it was demonstrated that the renal collecting duct plays an important role in renal fibrosis. Here, we investigated the role of Notch signaling in renal fibrosis using conditional knockout mice with the specific ablation of Mib1 in renal collecting duct principal cells. Methods: Mib1-floxed mice (Mib1f/f) were crossed with aquaporin 2 (AQP2)-Cre mice in order to generate principal cell-specific Mib1 knockout mice (Mib1f/f :AQP2-Cre+)...
May 26, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28704917/the-role-of-hypoxia-on-the-acquisition-of-epithelial-mesenchymal-transition-and-cancer-stemness-a-possible-link-to-epigenetic-regulation
#16
REVIEW
Chang Dong Yeo, Nahyeon Kang, Su Yeon Choi, Bit Na Kim, Chan Kwon Park, Jin Woo Kim, Young Kyoon Kim, Seung Joon Kim
A hypoxic microenvironment leads to cancer progression and increases the metastatic potential of cancer cells within tumors via epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. The hypoxic response pathway can occur under oxygen tensions of < 40 mmHg through hypoxia-inducible factors (HIFs), which are considered key mediators in the adaptation to hypoxia. Previous studies have shown that cellular responses to hypoxia are required for EMT and cancer stemness maintenance through HIF-1α and HIF-2α...
July 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28704916/three-dimensional-echocardiography-in-adult-congenital-heart-disease
#17
REVIEW
Hyun Suk Yang
Congenital heart disease (CHD) is now more common in adults than in children due to improvements in fetal echo, neonatal and pediatric care, and surgical techniques leading to dramatically increased survivability into adulthood. Adult patients with CHD, regardless of prior cardiac surgery, experience further cardiac problems or therapeutic challenges; therefore, a non-invasive, easily accessible echocardiographic examination is an essential follow-up tool. Among echocardiographic modalities, three-dimensional (3D) echocardiography provides better delineation of spatial relationships in complex cardiac geometries and more accurate volumetric information without geometric assumptions...
July 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28704915/treatment-of-diabetic-kidney-disease-current-and-future-targets
#18
REVIEW
Mi-Kyung Kim
Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease in Korea and worldwide, and is a risk factor for the development of cardiovascular complications. The conventional treatments for DKD are control of blood glucose and blood pressure levels by inhibiting the renin-angiotensin system. However, the prevalence of DKD continues to increase and additional therapies are required to prevent or ameliorate the condition. Many drugs have been, or are being, developed to target the molecular mechanisms in play in DKD...
July 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28704914/impact-of-early-diagnosis-on-functional-preservation-in-patients-with-rheumatoid-arthritis-the-early-bird-catches-the-worm
#19
Yun-Hong Cheon, Sang-Il Lee
No abstract text is available yet for this article.
July 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28704913/treatment-of-connective-tissue-disease-associated-interstitial-lung-disease-the-pulmonologist-s-point-of-view
#20
REVIEW
So-My Koo, Soo-Taek Uh
Interstitial lung disease (ILD) occurs in 15% of patients with collagen vascular disease (CVD), referred to as connective tissue disease (CTD). Despite advances in management strategies, ILD continues to be a significant cause of mortality in patients with CVD-associated ILD (CTD-ILD). There is a lack of randomized, clinical trials assessing pharmacological agents for CTD-ILD, except in cases of ILD-associated systemic sclerosis (SSc). This may be due to the lack of CTD cases available, the difficulty of histological confirmation of ILD, and the various types of CTD and ILD...
July 2017: Korean Journal of Internal Medicine
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