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International Journal of Biological Markers

Younghoon Kim, Xianyu Wen, Nam Yun Cho, Gyeong Hoon Kang
BACKGROUND: The prognostic value of immune cells expressing programmed cell death 1 (PD-1) and PD-1 ligand 1 (PD-L1) in cancer are controversial, and the potential differential impact of using tissue microarrays and whole tissue sections to assess the positivity of immune cells has not been addressed. METHODS: The current study included 30 eligible studies with 7251 patients that evaluated the relationship between tumor-infiltrating lymphocytes expressing PD-1/PD-L1 and overall survival and disease-free survival, or progression-free survival...
May 1, 2018: International Journal of Biological Markers
Xiao Li, Zhiqiang Qin, Jianxin Xue, Jianzhong Zhang, Yuxiao Zheng, Weizhang Xu, Ting Xu, Qing Zou
OBJECTIVE: This study was performed to investigate whether CSF-1 polymorphisms influenced the risk of renal cell carcinoma in a Chinese population. METHODS: The potentially functional polymorphisms in CSF-1 (rs333951 and rs2050462) were genotyped in this hospital-based case-control study, comprising 1512 renal cell carcinoma patients and 1691 controls in a Chinese population using the TaqMan assay. Furthermore, odds ratios (ORs) and 95% confidence intervals (CI) were used to estimate such an association...
May 1, 2018: International Journal of Biological Markers
Martin Boegemann, Christian Arsov, Boris Hadaschik, Kathleen Herkommer, Florian Imkamp, Jerzy-Roch Nofer, Joachim Gerß, Peter Albers, Axel Semjonow
INTRODUCTION: Total PSA (tPSA) and free PSA (fPSA) are the most commonly used biomarkers for early detection of prostate cancer. Despite standardization efforts, many available PSA assays may still produce discordant results. In the present study, we compared four PSA assays calibrated to the WHO standards 96/670 and 96/668 for tPSA and fPSA, respectively. METHODS: Within the scope of the Prostate Cancer Early Detection Study Based on a ''Baseline'' PSA Value in Young Men (PROBASE), we tested tPSA and fPSA in serum samples from 50 patients in the four different PROBASE sites using four WHO-calibrated assays from Roche (Elecsys, Cobas), Beckman-Coulter (Access-II) and Siemens (ADVIA Centaur)...
May 1, 2018: International Journal of Biological Markers
Min-Hang Zhou, Hong-Wei Zhou, Mo Liu, Jun-Zhong Sun
PURPOSE: The role of microRNA (miRNA) in cholangiocarcinoma was not clear. The aim of this study was to find the potential diagnostic and prognostic miRNA in cholangiocarcinoma patients. METHODS: The miRNA expression profiles in cholangiocarcinoma patients from The Cancer Genome Atlas and Gene Expression Omnibus (GSE53870) were analyzed. The comparison of overall survival was performed using the Kaplan-Meier method. The targeted genes of prognostic miRNA were identified in miRanda, PicTar, or TargetScan, and their cell signaling pathways were analyzed by the Database for Annotation, Visualization and Integrated Discovery...
April 1, 2018: International Journal of Biological Markers
Mohammad Hossein Sahami-Fard
BACKGROUND: Recent evidence suggests that -592 A/C polymorphism in the interleukin-10 (IL-10) gene may influence risk of gastrointestinal tract cancer; however, individual studies have provided conflicting and inconclusive results. Therefore, this meta-analysis was conducted to assess the association between IL-10 -592 A/C polymorphism and gastrointestinal tract cancer susceptibility. METHODS: EMBASE, PubMed, Web of Science, and China National Knowledge Infrastructure databases were searched for case-control studies published before 1 May 2017...
April 1, 2018: International Journal of Biological Markers
Jiguang Jia, Bin Huang, Zhengling Zhuang, Sen Chen
PURPOSE: Bone metastases from non-small cell lung cancer (NSCLC) are common, and current prognostic stratification methods are challenging to predict outcomes. The aim of the study is to examine circulating tumor DNA as a potential biomarker to gauge overall survival. METHODS: Late stage NSCLC patients associated with bone metastasis were recruited for the study. Circulating tumor DNA was quantified using droplet digital polymerase chain reaction, a sensitive assay that is capable to pick up low mutant DNA frequencies...
April 1, 2018: International Journal of Biological Markers
Andrea Gallotta, Laura Paneghetti, Viera Mrázová, Adriana Bednárová, Dáša Kružlicová, Vladimir Frecer, Stanislav Miertus, Alessandra Biasiolo, Andrea Martini, Patrizia Pontisso, Giorgio Fassina
Non-alcoholic steato-hepatitis (NASH) is a severe disease characterised by liver inflammation and progressive hepatic fibrosis, which may progress to cirrhosis and hepatocellular carcinoma. Clinical evidence suggests that in hepatitis C virus patients steatosis and NASH are associated with faster fibrosis progression and hepatocellular carcinoma. A safe and reliable non-invasive diagnostic method to detect NASH at its early stages is still needed to prevent progression of the disease. We prospectively enrolled 91 hepatitis C virus-positive patients with histologically proven chronic liver disease: 77 patients were included in our study; of these, 10 had NASH...
April 1, 2018: International Journal of Biological Markers
JingJing Yu, Jing Zhou, Fei Xu, Wei Bai, Wei Zhang
OBJECTIVE: Aurora kinase B (Aurora-B) is a crucial regulator of accurate mitosis. Abnormal Aurora-B expression is associated with aneuploidy and has been implicated in the pathogenesis and drug resistance in a variety of human cancers. However, little evidence is available regarding the role of Aurora-B in regulating drug response in non-small cell lung cancer (NSCLC), which is the most common type of lung cancer, and is characterized with poor prognosis and high mortality. METHOD: In the current study, we investigated the association of Aurora-B with the prognosis of NSCLC patients, and we also used the latest CRISPR/Cas9 system to explore the regulatory role of Aurora-B in NSCLC cells developing resistance to cisplatin (CDDP) and paclitaxel...
April 1, 2018: International Journal of Biological Markers
Pierpaolo Trimboli, Rosa Lauretta, Agnese Barnabei, Stefano Valabrega, Francesco Romanelli, Luca Giovanella, Marialuisa Appetecchia
AIM: Due to the limits of calcitonin, other markers are warranted to better manage medullary thyroid carcinoma patients, and procalcitonin has been reported as promising. Here we aimed to evaluate procalcitonin as a marker of medullary thyroid carcinoma in the post-treatment follow-up. METHODS: Medullary thyroid carcinoma patients previously treated by thyroidectomy were enrolled. After complete imaging work-up (i.e. ultrasonography, computed tomography, magnetic resonance and 18 FDG-PET-CT) we identified patients with structural recurrent/persistent medullary thyroid carcinoma (active medullary thyroid carcinoma) and subjects with no evidence of disease...
April 1, 2018: International Journal of Biological Markers
Sanjay Singh, Manish Gupta, Rajeev Kumar Seam, Harish Changotra
INTRODUCTION: Altered expression of many E2F family members have been reported in various human cancers. In this study, we investigated the role of non-synonymous single nucleotide polymorphisms (rs3213172 C/T, rs3213173 C/T, and rs3213176 G/A) of the gene E2F1 with cervical cancer. METHODS: A total of 181 samples including 90 cervical cancer patients and 91 healthy controls were genotyped. The genotype frequencies of these polymorphisms in collected samples were determined by either PCR-RFLP or PCR-ARFLP methods...
April 1, 2018: International Journal of Biological Markers
Yaser Mansoori, Mohammad Bagher Tabei, Alireza Askari, Pantea Izadi, Abdolreza Daraei, Mohammad Mehdi Naghizadeh, Zahra Zendehbad, Milad Bastami, Ziba Nariman-Saleh-Fam, Hosein Mansoori, Javad Tavakkoly-Bazzaz
BACKGROUND: Epidemiological and experimental literature indicates that the risk of breast cancer incidence is strongly linked to hormone-dependent factors, including reproductive history and obesity. However, the molecular mechanisms underlying the association between these factors and breast cancer risk are poorly understood. The aim of this study, therefore, was to determine whether obesity and reproductive history are associated with expression levels of two breast cancer-related long non-coding RNAs (lncRNAs), namely ZFAS1 and SRA1 in cancer-free breast tissues of women...
April 1, 2018: International Journal of Biological Markers
Filomena Cariola, Vittoria Disciglio, Anna M Valentini, Claudio Lotesoriere, Candida Fasano, Giovanna Forte, Luciana Russo, Antonio Di Carlo, Floranna Guglielmi, Andrea Manghisi, Ivan Lolli, Maria L Caruso, Cristiano Simone
INTRODUCTION: Lynch syndrome is caused by germline mutations in one of the mismatch repair genes ( MLH1, MSH2, MSH6, and PMS2) or in the EPCAM gene. Lynch syndrome is defined on the basis of clinical, pathological, and genetic findings. Accordingly, the identification of predisposing genes allows for accurate risk assessment and tailored screening protocols. CASE DESCRIPTION: Here, we report a family case with three family members manifesting the Lynch syndrome phenotype, all of which harbor the rare variant c...
April 1, 2018: International Journal of Biological Markers
Jinling Liao, Yang Chen, Jia Zhu, Qiuyan Wang, Zengnan Mo
OBJECTIVE: Breast cancer is the most widespread cancer in women, with a high mortality rate. This study aims to assess the association between single nucleotide polymorphisms (SNPs) of LOC643714 (rs12922061) and TOX3 (rs3803662) and breast cancer, as well as the clinical characteristics of tumors. MATERIALS AND METHODS: In total, 104 breast cancer patients and 118 healthy controls were recruited to our study. The genotyping was performed by the SNP scan method. General characteristics, the clinical characteristics of tumors and reproductive factors were included in the analysis...
April 1, 2018: International Journal of Biological Markers
Xiangwei Zhang, Yang Wang, Linping Zhao, Shaowei Sang, Lin Zhang
The platelet-to-lymphocyte ratio (PLR) is a useful prognostic factor in several cancers. However, the prognostic role of PLR in esophageal cancer remains controversial. The aim of this study is to evaluate the association between PLR and the oncologic outcome of esophageal cancer patients through a meta-analysis. Relevant articles were researched from Embase, PubMed, and Web of Science databases. The meta-analysis was performed using hazard ratio (HR) and 95% confidence intervals (CIs) as effect measures. Finally, 19 articles with 6134 patients were included in our study...
April 1, 2018: International Journal of Biological Markers
Michele De Bortoli, Valentina Miano, Lucia Coscujuela Tarrero
No abstract text is available yet for this article.
April 1, 2018: International Journal of Biological Markers
Eman T Elsayed, Perihan E Salem, Azaa M Darwish, Haytham M Fayed
BACKGROUND: Long non-coding RNAs (lncRNAs) Hox transcript antisense intergenic RNA ( HOTAIR) has been suggested to be implicated in gastric cancer tumorigenesis and progression; however, little is known about the role of the plasma HOTAIR in gastric cancer diagnosis and prognosis. OBJECTIVE: The current study was aimed at investigating the clinical relevance of plasma long non-coding HOTAIR as a non-invasive diagnostic biomarker in gastric cancer. METHODS: Plasma HOTAIR expression was measured in 50 patients with newly diagnosed gastric cancer and 50 age- and sex-matched healthy controls using quantitative reverse transcription polymerase chain reaction...
April 1, 2018: International Journal of Biological Markers
Yijuan Liu, Ting Wu, Dong Lu, Jiantao Zhen, Lin Zhang
BACKGROUND: CD44 has recently been reported as a biomarker for pancreatic cancer. However, the predictive value of CD44 in pancreatic cancer remains controversial. Therefore, we performed this meta-analysis to evaluate the association between the expression of CD44 and clinicopathological features, and the outcome of pancreatic cancer patients. MATERIALS AND METHOD: A comprehensive literature search was performed using PubMed, Embase, and Chinese National Knowledge Infrastructure...
April 1, 2018: International Journal of Biological Markers
Lin-Lin Cao, Changzheng Du, Hangqi Liu, Lin Pei, Li Qin, Mei Jia, Hui Wang
OBJECTIVE: Lysine-specific demethylase 2A (KDM2A), a specific H3K36me1/2 demethylase, has been reported to be closely associated with several types of cancer. In this study, we aimed to investigate the expression and function of KDM2A in colorectal adenocarcinoma. METHODS: A total of 215 colorectal adenocarcinoma specimens were collected, and then subjected to immunohistochemistry assay to evaluate the expression levels of KDM2A, cyclin D1 and other proteins in colorectal adenocarcinoma tissues...
April 1, 2018: International Journal of Biological Markers
Quan Zhou, Man-Zhen Zuo, Ze He, Hai-Rong Li, Wei Li
BACKGROUND: Circulating microRNAs (miRNAs) are proposed as promising non-invasive diagnostic biomarkers for many cancers. However, the diagnostic value of circulating miRNAs in ovarian cancer is inconsistent in different studies. Thus we performed this meta-analysis to systematically evaluate the diagnostic value of circulating miRNAs in ovarian cancer. METHODS: Eligible studies that were published prior to 30 June 2017 were searched from the PubMed, EMBASE, Cochrane Library, and Chinese National Knowledge Infrastructure...
April 1, 2018: International Journal of Biological Markers
Giulio Metro, Diana Giannarelli, Angelo Sidoni, Rita Chiari, Guido Bellezza
No abstract text is available yet for this article.
April 1, 2018: International Journal of Biological Markers
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