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International Journal of Biological Markers

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https://www.readbyqxmd.com/read/29148014/unfavorable-clinical-implications-of-peripheral-blood-cd44-and-cd54-lymphocytes-in-patients-with-lung-cancer-undergoing-chemotherapy
#1
Zhuanbo Luo, Yun Wang, Yanru Lou, Chao Cao, Richard Hubbard, Ning Xu, Xiaoping Huang
BACKGROUND: There is an unmet need for identification of additional prognostic markers for lung cancer. The aim of this study was to identify novel clinical and immunological predictors of prognosis in lung cancer patients. METHODS: Lymphocyte subsets CD3+, CD4+, CD8+, CD4+/8+, CD25+, CD69+, CD44+ and CD54+ were quantified in peripheral blood using flow cytometry, for 203 newly diagnosed lung cancer patients and 120 healthy controls. RESULTS: The levels of CD3+, CD4+, CD8+, CD4+/CD8+ and CD69+ lymphocytes were significantly lower in patients with lung cancer compared with the healthy control group, while CD54+ and CD44+ lymphocytes were significantly higher...
November 15, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29148015/clinical-performance-and-utility-of-a-nnmt-based-urine-test-for-bladder-cancer
#2
Valentina Pozzi, Giulia Di Ruscio, Davide Sartini, Roberto Campagna, Riccardo Seta, Paola Fulvi, Alexia Vici, Giulio Milanese, Gabriele Brandoni, Andrea B Galosi, Rodolfo Montironi, Monia Cecati, Monica Emanuelli
BACKGROUND: Bladder cancer (BC) represents the most common neoplasm of the urinary tract. Although cystoscopy and urine cytology represent the gold standard methods to monitor BC, both procedures have limitations. Therefore, the identification of reliable biomarkers for early and noninvasive detection of BC is urgently required. METHODS: In this study, we analyzed nicotinamide N-methyltransferase (NNMT) expression in urine samples from 55 BC patients and 107 controls, using real-time polymerase chain reaction (PCR)...
November 11, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29148016/association-of-xpg-gene-rs751402-polymorphism-with-gastric-cancer-risk-a-meta-analysis-in-the-chinese-population
#3
Jun Liang, Ya-Yun Xu, Cheng Zhang, Qing-Rong Xia
BACKGROUND: Previous studies have revealed a conflicting relationship of xeroderma pigmentosum group G (XPG) gene polymorphism with gastric cancer (GC) risk. To our knowledge, this is the first meta-analysis to investigate the association between rs751402 mutation located on the XPG promoter region and GC risk. METHODS: We undertook a meta-analysis by identifying relevant articles from the PubMed, Web of Science and China National Knowledge Infrastructure (CNKI) databases on February 28, 2017...
November 9, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29099538/how-immunologic-and-genetic-biomarkers-impact-hodgkin-lymphoma-classification-diagnosis-and-management-a-huge-potential-that-yet-needs-to-be-exploited
#4
Antonino Carbone, Annunziata Gloghini
"Ne è passata di acqua sotto i ponti." It has been a long time since the diagnosis of Hodgkin lymphoma (HL) was exclusively based on the detection of typical Reed-Sternberg cells and the recognition of the characteristic morpho-histological background, as well as on the pathologist's skill. The discovery of immunologic, molecular genetic and virologic biomarkers has provided an objective contribution to the diagnosis and a scientific basis for a modern classification of HL. Recent updates have clarified the nature of the so-called nodular lymphocyte predominant HL and its link to the T-cell/histiocyte-rich large B-cell lymphomas as well as its relationship with the lymphocyte-rich subset of classical HL (CHL)...
October 28, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29076521/btg1-low-expression-in-pancreatic-ductal-adenocarcinoma-is-associated-with-a-poorer-prognosis
#5
Yufang Huang, Jiawei Zheng, Ting Tan, Li Song, Shanshan Huang, Yan Zhang, Lin Lin, Jingnan Liu, Peichan Zheng, Xiong Chen, Xi Chen, Xuenong Ouyang
OBJECTIVE: BTG1 is a member of the TOB/BTG protein family, which is a transducer of ErbB-2 and TOB2. It is known to inhibit tumor genesis, but its role in pancreatic ductal adenocarcinoma (PDAC) is still unknown. The purpose of this study is to investigate the expression of BTG1 protein in PDAC and to determine its prognostic significance. METHODS: Immunohistochemistry is used to determine the protein expression of the BTG1 gene in 79 surgically resected PDAC. The association of BTG1 expression with all the patients' clinicopathologic parameters, including survival, was analyzed using statistical software...
October 25, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29076522/prognostic-value-of-the-glasgow-prognostic-score-in-lung-cancer-evidence-from-10-studies
#6
Jing Jin, Kejia Hu, Yongzhao Zhou, Weimin Li
OBJECTIVE: To conduct a meta-analysis of prospective and retrospective studies to reveal the relationship between the Glasgow prognostic score (GPS) and overall survival (OS) or progression-free survival (PFS) in patients with lung cancer. METHODS: Correlative studies were included by searching the databases of PubMed, Web of Science, Embase, and PubMed Cochrane Library until April 16, 2017. We combined the hazard ratios (HRs) and 95% confidence intervals (CIs) to assess the correlation between GPS and OS or PFS in patients with lung cancer...
October 24, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29076520/circulating-or-tissue-micrornas-and-extracellular-vesicles-as-potential-lung-cancer-biomarkers-a-systematic-review
#7
Yan Song, Xiuli Yu, Zongmei Zang, Guijuan Zhao
For both lung cancer patients and clinical physicians, tumor biomarkers for more efficient early diagnosis and prediction of prognosis are always wanted. Biomarkers in circulating serum, including microRNAs (miRNAs) and extracellular vesicles, hold the greatest possibilities to partially substitute for tissue biopsy. In this systematic review, studies on circulating or tissue miRNAs and extracellular vesicles as potential biomarkers for lung cancer patients were reviewed and are discussed. Furthermore, the target genes of the miRNAs indicated were identified through the miRTarBase, while the relevant biological processes and pathways of miRNAs in lung cancer were analyzed through MiRNA Enrichment Analysis and Annotation (MiEAA)...
October 24, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29048700/erratum-to-circulating-tumor-markers-a-guide-to-their-appropriate-clinical-use-comparative-summary-of-recommendations-from-clinical-practice-guidelines-part-1-part-2-part-3
#8
(no author information available yet)
Erratum To: Circulating tumor markers: a guide to their appropriate clinical use | Comparative summary of recommendations from clinical practice guidelines (PART 1) Gion M, Trevisiol C, Rutjes AW, Rainato G, Fabricio AS. Int J Biol Markers. 2016 Dec 23;31(4):e332-e367. doi: 10.5301/jbm.5000251. Circulating tumor markers: a guide to their appropriate clinical use | Comparative summary of recommendations from clinical practice guidelines (PART 2).Gion M, Trevisiol C, Rutjes AWS, Rainato G, Fabricio ASC. Int J Biol Markers...
October 13, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29027179/association-of-dnmt3b-283t-c-polymorphism-with-risk-of-lung-and-gastric-cancer-a-case-control-study-and-a-meta-analysis
#9
Xianhong Feng, Jingdong Wang, Xiuli Gu, Jingli Zhang, Xiaolin Li, Zhi Tao, Jiebing Chen, Bifeng Chen
PURPOSE: To investigate the association of DNMT3B -283T>C polymorphism with the risk of lung or gastric cancer, which was followed by a meta-analysis. METHODS: The genotyping of -283T>C was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and was confirmed by sequencing. RESULTS: The results of this case-control study showed that -283T>C was not associated with the risk of lung or gastric cancer, and further stratified analysis according to age, gender, smoking status, and alcohol status confirmed the present finding...
October 12, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28983895/lncrna-ghet1-promotes-esophageal-squamous-cell-carcinoma-cells-proliferation-and-invasion-via-induction-of-emt
#10
Hongfen Liu, Qiang Zhen, Yakun Fan
BACKGROUND: Recent studies have shown that long noncoding RNA (lncRNA) gastric carcinoma highly expressed transcript 1 (GHET1) was involved in the progression of tumors. However, the role of GHET1 in esophageal squamous cell carcinoma (ESCC) remains unclear. METHODS: The expression of lncRNA GHET1 was examined in 55 paired ESCC tissues and adjacent nontumor tissues. Molecular and cellular techniques were used to explore the role of GHET1 on ESCC cells. RESULTS: Our data showed that GHET1 expression was significantly increased in ESCC tissues and cell lines...
October 4, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28967068/the-importance-of-hcg-in-human-endometrial-adenocarcinoma-and-breast-cancer
#11
Alexandra C Kölbl, Kristina Schlenk, Nils Behrendt, Ulrich Andergassen
Human chorionic gonadotropin (hCG) is a peptide hormone which plays an important role during pregnancy. But its impact is not limited to pregnancy; it also influences tumor formation and metastatic outgrowth, especially in endometrial adenocarcinoma and breast cancer. This review summarizes what has been written in the literature about the role of hCG as a tumor marker in these 2 gynecological malignancies and also about the signal transduction pathways in which hCG is involved. HCG can, on the one hand, be a marker for the progression of a malignant disease, and on the other hand, it may be a point for therapeutical intervention, so further research into this molecule would be very much worthwhile...
September 25, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28967067/changes-of-breast-cancer-staging-when-ajcc-prognostic-staging-manual-is-used-a-retrospective-analysis-of-a-chinese-cohort
#12
Jinhua Ding, Weizhu Wu, Jianjiang Fang, Yudong Chu, Siming Zheng, Li Jiang
BACKGROUND: This study aimed to investigate staging changes for Chinese breast cancer patients assessed by the 7th (anatomic) and 8th (prognostic) editions of the AJCC staging manual, and to explore the predictive factors for these changes. METHODS: Data of patients who received curative surgery for stage I-III breast cancer at Ningbo Medical Center Lihuili Eastern Hospital were retrospectively reviewed. The assessment of staging was according to the criteria of the 7th and 8th editions of the AJCC staging manual...
September 25, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28967066/clinical-implications-for-pro-grp-in-small-cell-lung-cancer-a-single-center-experience
#13
Stefano Cavalieri, Daniele Morelli, Antonia Martinetti, Giulia Galli, Federico Nichetti, Filippo de Braud, Marco Platania
BACKGROUND: Recently, pro-gastrin-releasing peptide (pro-GRP) became available as an alternative sensitive, specific and reliable tumor marker for patients with small cell lung cancer (SCLC), both in limited (LD) and diffuse disease (DD). METHODS: We retrospectively analyzed pro-GRP, neuron-specific enolase (NSE) and CEA in patients with SCLC and non-small cell lung cancer (NSCLC). Serum pro-GRP level was measured with electrochemiluminescence at our laboratory (cutoff 77...
September 25, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28967065/current-status-and-future-prospects-of-biomarkers-in-the-diagnosis-of-hepatocellular-carcinoma
#14
Yunsheng Zhao, Qin Gao, Liu Pei, Chunhua Wang, Liang Jin, Fei Liao
Hepatocellular carcinoma (HCC) has one of the highest death rates of any cancer in the world, and its incidence is increasing worldwide. Early-stage diagnosis of HCC is thus crucial for medical treatment. Detection of tumor biomarkers is one of the main methods for the early diagnosis of HCC. At present, α-fetoprotein (AFP) is the most practical serum biomarker for HCC diagnosis. However, the diagnostic accuracy of HCC with serum AFP exhibits both sensitivity and specificity far below satisfaction, especially with small sizes of HCC...
September 22, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28967064/long-noncoding-rna-zeb1-as1-expression-predicts-progression-and-poor-prognosis-of-colorectal-cancer
#15
Jining Fu, Yongyuan Cui
BACKGROUND: ZEB1-AS1 acts as an oncogene in hepatocellular carcinoma, accelerating tumor growth and promoting metastasis. However, its roles in colorectal cancer (CRC) remain unclear. METHODS: In this study, we determined the expression of ZEB1-AS1 in CRC tissues by quantitative real-time polymerase chain reaction (qRT-PCR). Additionally, we investigated the relationship between various clinicopathological features of CRC patients and ZEB1-AS1 expression, and evaluated the diagnostic and prognostic value of ZEB1-AS1 in CRC...
September 14, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28885660/cortactin-and-phosphorylated-cortactin-tyr421-and-tyr466-expression-in-supraglottic-laryngeal-carcinomas-and-lymph-node-metastases
#16
Gino Marioni, Marco Lionello, Rosario Marchese-Ragona, Elena Fasanaro, Elisa Valentini, Elisabetta Zanoletti, Paola Stritoni, Giulia Ramacciotti, Vincenza Guzzardo, Luciano Giacomelli, Giovanni Ralli, Giancarlo Ottaviano, Stella Blandamura
BACKGROUND: The most important adverse prognostic factor for laryngeal squamous cell carcinoma (LSCC) is the presence of cervical lymph node metastases. The supraglottic area of the larynx is richly supplied with lymphatics, and 25%-75% of supraglottic carcinomas metastasize in neck lymph nodes. Cortactin is a multidomain protein related to actin cytoskeleton regulation, podosome and lamellipodia formation, integrin signaling, axon guidance and extracellular matrix degradation. Cortactin is involved in metastasis formation because of its role in cell mobility...
September 5, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28885661/egfr-as-a-clinical-marker-in-glioblastomas-and-other-gliomas
#17
Fadi S Saadeh, Rami Mahfouz, Hazem I Assi
Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein and a member of the tyrosine kinase superfamily receptor. Gliomas are tumors originating from glial cells, which show a range of aggressiveness depending on grade and stage. Many EGFR gene alterations have been identified in gliomas, especially glioblastomas, including amplifications, deletions and single nucleotide polymorphisms (SNPs). Glioblastomas are discussed as a separate entity due to their high correlation with EGFR mutants and the reported association of the latter with survival and response to treatment in this glioma subgroup...
September 2, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28885659/the-role-of-serum-neuron-specific-enolase-in-patients-with-prostate-cancer-a-systematic-review-of-the-recent-literature
#18
Barbara Muoio, Mariarosa Pascale, Enrico Roggero
In this systematic review, we evaluated the value of serum concentrations of neuron-specific enolase (NSE) in patients with prostate cancer (PCa) in order to clarify the possible role of NSE in the diagnosis, management, treatment and monitoring of PCa. A comprehensive search of the recent literature was conducted to find relevant data on the role of NSE in PCa. Two hundred and eighty-two records were revealed, and 19 articles including 1,772 patients with PCa (either confirmed or suspected) were selected. After reviewing the articles, the major result was that elevated serum NSE appears to correlate with prognosis in advanced PCa, particularly in patients with progressive and metastatic castration-resistant PCa...
September 2, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28885658/circulating-tumor-dna-is-effective-for-detection-of-kras-mutation-in-colorectal-cancer-a-meta-analysis
#19
Min Tang, Zhenghua Deng, Baolin Li, Ying Peng, Min Song, Jinbo Liu
BACKGROUND: Circulating tumor DNA (ctDNA) offers a novel and minimally invasive approach to the detection of the KRAS oncogene mutation in colorectal cancer. This study was conducted to compare the prognostic value of ctDNA with that of the current gold standard tumor tissue analysis. METHODS: A systematic literature review was conducted to identify relevant articles published from inception to December 27, 2016; the PubMed, Web of Science, Embase, Wanfang and China National Knowledge Infrastructure databases were searched...
August 29, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28862716/role-of-psa-response-as-a-marker-for-efficacy-of-patients-with-castration-resistant-prostate-cancer-treated-with-novel-hormonal-therapies
#20
Giandomenico Roviello
No abstract text is available yet for this article.
August 28, 2017: International Journal of Biological Markers
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