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International Journal of Biological Markers

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https://www.readbyqxmd.com/read/28885661/egfr-as-a-clinical-marker-in-glioblastomas-and-other-gliomas
#1
Fadi S Saadeh, Rami Mahfouz, Hazem I Assi
Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein and a member of the tyrosine kinase superfamily receptor. Gliomas are tumors originating from glial cells, which show a range of aggressiveness depending on grade and stage. Many EGFR gene alterations have been identified in gliomas, especially glioblastomas, including amplifications, deletions and single nucleotide polymorphisms (SNPs). Glioblastomas are discussed as a separate entity due to their high correlation with EGFR mutants and the reported association of the latter with survival and response to treatment in this glioma subgroup...
September 5, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28885660/cortactin-and-phosphorylated-cortactin-tyr421-and-tyr466-expression-in-supraglottic-laryngeal-carcinomas-and-lymph-node-metastases
#2
Gino Marioni, Marco Lionello, Rosario Marchese-Ragona, Elena Fasanaro, Elisa Valentini, Elisabetta Zanoletti, Paola Stritoni, Giulia Ramacciotti, Vincenza Guzzardo, Luciano Giacomelli, Giovanni Ralli, Giancarlo Ottaviano, Stella Blandamura
BACKGROUND: The most important adverse prognostic factor for laryngeal squamous cell carcinoma (LSCC) is the presence of cervical lymph node metastases. The supraglottic area of the larynx is richly supplied with lymphatics, and 25%-75% of supraglottic carcinomas metastasize in neck lymph nodes. Cortactin is a multidomain protein related to actin cytoskeleton regulation, podosome and lamellipodia formation, integrin signaling, axon guidance and extracellular matrix degradation. Cortactin is involved in metastasis formation because of its role in cell mobility...
September 5, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28885659/the-role-of-serum-neuron-specific-enolase-in-patients-with-prostate-cancer-a-systematic-review-of-the-recent-literature
#3
Barbara Muoio, Mariarosa Pascale, Enrico Roggero
In this systematic review, we evaluated the value of serum concentrations of neuron-specific enolase (NSE) in patients with prostate cancer (PCa) in order to clarify the possible role of NSE in the diagnosis, management, treatment and monitoring of PCa. A comprehensive search of the recent literature was conducted to find relevant data on the role of NSE in PCa. Two hundred and eighty-two records were revealed, and 19 articles including 1,772 patients with PCa (either confirmed or suspected) were selected. After reviewing the articles, the major result was that elevated serum NSE appears to correlate with prognosis in advanced PCa, particularly in patients with progressive and metastatic castration-resistant PCa...
September 5, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28885658/circulating-tumor-dna-is-effective-for-detection-of-kras-mutation-in-colorectal-cancer-a-meta-analysis
#4
Min Tang, Zhenghua Deng, Baolin Li, Ying Peng, Min Song, Jinbo Liu
BACKGROUND: Circulating tumor DNA (ctDNA) offers a novel and minimally invasive approach to the detection of the KRAS oncogene mutation in colorectal cancer. This study was conducted to compare the prognostic value of ctDNA with that of the current gold standard tumor tissue analysis. METHODS: A systematic literature review was conducted to identify relevant articles published from inception to December 27, 2016; the PubMed, Web of Science, Embase, Wanfang and China National Knowledge Infrastructure databases were searched...
September 2, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28862716/role-of-psa-response-as-a-marker-for-efficacy-of-patients-with-castration-resistant-prostate-cancer-treated-with-novel-hormonal-therapies
#5
Giandomenico Roviello
No abstract text is available yet for this article.
August 28, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28862715/prognostic-role-of-ezh2-in-gliomas-a-meta-analysis
#6
Jung-Soo Pyo, Dong-Wook Kang
BACKGROUND: The aim of this study was to elucidate the clinicopathological significance of enhancer of zeste homolog 2 (EZH2) expression in gliomas, including its incidence and prognostic role. In addition, we investigated the concordance between immunohistochemistry and polymerase chain reaction for determining the presence or absence of EZH2 in these tumors. METHODS: The current meta-analysis included 1,049 gliomas with various WHO tumor grades from 12 eligible studies, which were analyzed for positivity of EZH2 and correlation between EZH2 expression and prognosis...
August 28, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28862714/serum-albumin-levels-in-relation-to-tumor-parameters-in-hepatocellular-carcinoma-patients
#7
Brian I Carr, Vito Guerra
BACKGROUND: Serum albumin levels have been shown to have prognostic significance in hepatocellular carcinoma (HCC), as part of an inflammatory index. The aim of this study was to examine the possible relationship of serum albumin levels to parameters of HCC aggressiveness. METHODS: A large HCC patient cohort was retrospectively examined, and the possible relationships of albumin levels to tumor diameter, multifocality, portal vein thrombosis (PVT) and α-fetoprotein levels were examined...
August 28, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28862713/meta-analysis-of-micrornas-as-potential-biomarkers-for-detecting-esophageal-carcinoma-in-asian-populations
#8
Mei Li, Fei Wu, Yu Ji, Lan Yang, Feng Li
BACKGROUND: An Increasing number of studies in the literature have shown that microRNAs (miRNAs) can be used as early diagnostic markers for esophageal carcinoma (EC), but their conclusions remain controversial. Hence, we performed this meta-analysis to evaluate the diagnostic accuracy of using miRNAs in EC and to provide an experimental basis for early diagnosis of the disease. METHODS: This meta-analysis included 39 Asian studies from 18 articles, which covered 3,708 EC patients and 2,689 healthy controls...
August 28, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28862712/enhanced-liver-fibrosis-test-as-a-reliable-tool-for-assessing-fibrosis-in-nonalcoholic-fatty-liver-disease-in-a-clinical-setting
#9
Luca Miele, Teresa De Michele, Giuseppe Marrone, Maria Antonietta Isgrò, Umberto Basile, Consuelo Cefalo, Marco Biolato, Fabio Maria Vecchio, Gian Lodovico Rapaccini, Antonio Gasbarrini, Cecilia Zuppi, Antonio Grieco
BACKGROUND: Liver fibrosis is the main determinant and predictor of the clinical course of nonalcoholic fatty liver disease (NAFLD). To date, a liver biopsy is still considered the gold standard for staging fibrosis. The aim of this study was to investigate the diagnostic accuracy of the commercial enhanced liver fibrosis (ELF) test manufacturer's cutoff value (≥9.8) in identifying severe fibrosis for adult patients with histologically confirmed NAFLD. METHODS: We tested the ELF test in a clinical practice, prospective cohort of 82 consecutive patients who consecutively underwent percutaneous liver biopsy...
August 28, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28799624/neutrophil-to-lymphocyte-ratio-as-prognostic-indicator-for-patients-with-esophageal-squamous-cell-cancer
#10
Guo-Dong Gao, Bo Sun, Xian-Bin Wang, Shi-Meng Wang
BACKGROUND: This study aimed to evaluate the correlation between neutrophil to lymphocyte ratio (NLR) with overall survival (OS) of esophageal squamous cell carcinoma (ESCC) patients. METHOD: Records of patients with diagnosed ESCC were reviewed. Leukocyte counts and patients' characteristics were extracted from their clinical records to calculate NLR. Correlation between NLR and baseline characteristics with overall survival (OS) was then analyzed using Cox regression...
August 7, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28777433/apoptosis-regulator-bcl-2-is-an-independent-prognostic-marker-for-worse-overall-survival-in-triple-negative-breast-cancer-patients
#11
Petar Ozretic, Ilija Alvir, Bozena Sarcevic, Zeljko Vujaskovic, Zrinka Rendic-Miocevic, Ana Roguljic, Lidija Beketic-Oreskovic
BACKGROUND: The objective of this study was to examine the prognostic significance of carbonic anhydrase IX (CAIX), an endogenous marker for tumor hypoxia; the cellular tumor antigen p53; and the apoptosis regulator Bcl-2, in triple-negative breast cancer (TNBC) patients. METHODS: Immunohistochemically determined expression of CAIX, p53, Bcl-2 and proliferation factor Ki-67, analyzed in 64 paraffin-embedded TNBC tissue samples, was used to assess their relation to clinicopathological variables and prognostic implications for overall survival (OS)...
July 29, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28777431/involvement-of-poly-adp-ribose-polymerase-1-in-chinese-patients-with-glioma-a-potential-target-for-effective-patient-care
#12
Jinhong Ren, Peilan Jia, Hongxia Feng, Xiuhua Li, Jinghui Zhao, Yunxia Sun
OBJECTIVE: We aimed to evaluate the genetic variation of poly(ADP-ribose) polymerase-1 (PARP-1) in the development of gliomas among Chinese individuals. MATERIALS AND METHODS: Patients with a confirmed diagnosis of glioma and healthy individuals with no clinical symptoms of glioma were enrolled at Liaocheng People's Hospital, China. Genetic polymorphisms were studied in plasma samples by polymerase chain reaction-restriction fragment length polymorphism assay. Cytokine levels were measured routinely in serum samples by sandwich ELISA technique...
July 29, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28777432/comparison-of-a-prototype-reverse-hybridization-assay-and-methylight-for-detection-of-sfrp2-promotor-methylation-in-fecal-dna
#13
Gernot Kriegshäuser, Dietmar Enko, Matthias Zitt, Michael Oberwalder, Christian Oberkanins, Dietmar Öfner, Robert Zeillinger, Hannes Maximilian Müller
BACKGROUND: This study aimed to evaluate the diagnostic performance of a novel nonquantitative methylation-specific reverse hybridization (MSRH) assay to detect secreted frizzled-related protein 2 (SFRP2) promotor methylation in fecal DNA. METHODS: SFRP2 promoter methylation was investigated in stool DNA isolated from 18 colorectal cancer (CRC) patients and 22 healthy controls using the MSRH assay based on methylation-specific DNA amplification followed by reverse hybridization of biotinylated amplicons to sequence-specific methylation detection probes, with MethyLight serving as a reference method...
July 26, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28708205/mir-411-functions-as-a-tumor-suppressor-in-renal-cell-cancer
#14
Xintao Zhang, Meng Zhang, Jianli Cheng, Zhaojie Lv, Feng Wang, Zhiming Cai
BACKGROUND: Recent studies have revealed that microRNAs (miRNAs) play important roles as oncogenes or tumor suppressors in tumorigenesis and tumor development, by negatively regulating protein expression. A previous study of microarrays identified that miR-411 was down-regulated in renal cell carcinoma (RCC), while few studies investigating the role of miR-411 in the pathogenesis of RCC have been performed. METHODS: We assessed the miR-411 expression in RCC and paired adjacent normal tissues, as well as in RCC cell lines and a normal renal cell line, by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR)...
July 11, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28708207/variations-in-transrenal-dna-and-comparison-with-plasma-dna-as-a-diagnostic-marker-for-colorectal-cancer
#15
Fang Tian, Yuanfang Liao, Yanfang Zhang
BACKGROUND: Transrenal DNA can potentially be useful in the disease management of colorectal cancer (CRC) and has potential diagnostic utility. Our study aimed to conduct preoperative and postoperative analysis of KRAS-positive patients, using transrenal DNA compared with plasma DNA. This is critically needed for disease diagnostics and treatment response monitoring. METHODS: CRC patients at different stages of the disease and with different molecular profiles were recruited for serial time-point analysis...
July 8, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28708206/iqgap1-silencing-suppresses-the-malignant-characteristics-of-laryngeal-squamous-cell-carcinoma-cells
#16
Xiaoxia Wang, Chun He, Chaohui Li, Benhong Ren, Qing Deng, Wei Gao, Binquan Wang
BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) has a poor prognosis due to recurrence and metastasis. IQ-domain GTPase-activating protein 1 (IQGAP1), a scaffold protein, plays an important role in tumorigenesis and malignant development. In this study, we aimed to explore the role of IQGAP1 in LSCC. METHODS: Expression of IQGAP1 in human LSCC specimens was assessed by immunohistochemistry. We also evaluated the roles of IQGAP1 in cell proliferation, migration and invasion and epithelial-to-mesenchymal transition (EMT) in Hep-2 cells...
July 8, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28708208/relationship-between-clinical-toxicities-and-ercc1-rs3212986-and-xrcc3-rs861539-polymorphisms-in-cervical-cancer-patients
#17
Sílvia Soares, Augusto Nogueira, Ana Coelho, Joana Assis, Deolinda Pereira, Isabel Bravo, Rui Medeiros
BACKGROUND: Several studies have suggested that there are single nucleotide polymorphisms (SNPs) that can be considered potential biomarkers in the prognosis and therapeutic response of cancer patients. The present study investigated the association between ERCC1 rs3212986 and XRCC3 rs861539 polymorphisms and clinical toxicities induced by chemoradiotherapy (CRT) in cervical cancer. METHODS: This hospital-based retrospective cohort study included 260 patients with cervical cancer, FIGO stages Ib2-IVa, who underwent CRT (cisplatin)...
July 7, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28430338/yap-taz-and-areg-expression-in-eighth-cranial-nerve-schwannoma
#18
Alessandro Martini, Gino Marioni, Elisabetta Zanoletti, Rocco Cappellesso, Roberto Stramare, Elena Fasanaro, Chiara Faccioli, Luciano Giacomelli, Luca Denaro, Domenico D'Avella, Antonio Mazzoni, Ambrogio Fassina
BACKGROUND: Although the diagnosis and treatment of eighth cranial nerve (VIII CN) schwannoma (acoustic neuroma) has improved over the years, no factors capable of predicting tumor growth have been identified as yet. This study is a preliminary investigation of the expression in sporadic VIII CN schwannomas of Yes-associated protein (YAP), transcriptional coactivator with PDZ-binding motif (TAZ), and amphiregulin (AREG), a direct target gene of YAP and TAZ. The expression of YAP, TAZ and AREG was correlated with the volumetric dimensions of tumors on contrast-enhanced magnetic resonance imaging (ceMRI)...
July 24, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28665451/discordance-in-ras-mutations-between-primary-colon-tumor-and-metastases-a-real-event-or-a-matter-of-methodology
#19
Alfonso De Stefano, Mario Rosanova, Umberto Malapelle, Maurizio Martini, Stefano De Falco, Laura Attademo, Giovanni Fiore, Tonia Cenci, Claudio Bellevicine, Sabino De Placido, Giancarlo Troncone, Chiara Carlomagno
BACKGROUND: Analysis of K- and N-RAS mutations is mandatory before planning treatment of metastatic colorectal cancer, because only RAS wild-type (WT) patients can benefit from treatment with anti-EGFR monoclonal antibodies (cetuximab and panitumumab). CASE REPORT: Here we report the case of a 69-year-old male patient affected by metastatic sigmoid cancer. He underwent left hemicolectomy, and histology diagnosed a well-differentiated, pT4, node-positive adenocarcinoma; KRAS analysis performed with direct sequencing identified a mutation in exon 2 of the KRAS gene (GGT->GTT)...
June 20, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28665452/genetic-polymorphisms-of-vitamin-d-metabolism-genes-and-serum-level-of-vitamin-d-in-colorectal-cancer
#20
Verônica Marques Vidigal, Pedro Nazareth Aguiar Junior, Tiago Donizetti Silva, Juliana de Oliveira, Célia Aparecida Marques Pimenta, Aledson Vitor Felipe, Nora Manoukian Forones
BACKGROUND: The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels. The aim of this study was to investigate the relationship of the polymorphisms of VDR (ApaI and BsmI), CYP27B1 and CYP24A1 with serum vitamin D levels in both forms, 25(OH)D3 (circulating form) and 1,25(OH)2D3 (active form), in colorectal cancer (CRC) patients. METHODS: One hundred fifty-two CRC patients and 321 controls were included...
June 19, 2017: International Journal of Biological Markers
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