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International Reviews of Immunology

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https://www.readbyqxmd.com/read/28692310/role-of-micrornas-in-shaping-innate-immunity-and-as-therapeutic-targets-for-autoimmune-diseases
#1
Himanshu Kumar, Adrian Bot
No abstract text is available yet for this article.
July 10, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28574736/multiple-functions-of-the-e3-ubiquitin-ligase-chip-in-immunity
#2
Shaohua Zhan, Tianxiao Wang, Wei Ge
The carboxyl terminal of Hsp70-interacting protein (CHIP) is an E3 ubiquitin ligase that plays a pivotal role in the protein quality control system by shifting the balance of the folding-refolding machinery toward the degradative pathway. However, the precise mechanisms by which nonnative proteins are selected for degradation by CHIP either directly or indirectly via chaperone Hsp70 or Hsp90 are still not clear. In this review, we aim to provide a comprehensive model of the mechanism by which CHIP degrades its substrate in a chaperone-dependent or direct manner...
June 2, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28537793/in-this-issue-role-of-immune-cells-immune-modulating-factors-and-immunotoxins-in-cancer-immunotherapy
#3
Himanshu Kumar, Adrian Bot
No abstract text is available yet for this article.
May 24, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28481647/the-predictive-value-of-transforming-growth-factor-%C3%AE-in-wilms-tumor-immunopathogenesis
#4
Marla Karine Amarante, Carlos Eduardo Coral de Oliveira, Carolina Batista Ariza, Alberto Yoichi Sakaguchi, Cintya Mayumi Ishibashi, Maria Angelica Ehara Watanabe
Wilms tumor is the most common kidney malignancy in children, especially in children aged less than 6 years. Although therapeutic approach has reached successful rates, there is still room for improvement. Considering the tumor microenvironment, cytokines represent important elements of interaction and communication between tumor cells, stroma, and immune cells. In this regard, the transforming growth factor beta (TGF-β) family members play significant functions in physiological and pathological conditions, particularly in cancer...
May 8, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28471289/role-of-micrornas-in-the-development-and-function-of-innate-immune-cells
#5
S Manoj Kumar Kingsley, B Vishnu Bhat
MicroRNAs act as crucial post-transcriptional regulators of various biological processes. Their role in regulating the differentiation and development of the various immune cells of the body is of paramount importance. The development of immune cells from the hematopoietic progenitors involves the complex interplay of transcription factors, cell signaling proteins and growth factors. MicroRNAs govern and sometimes work in a common axis alongside these factors to regulate the differentiation of immune cells...
May 4, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28471269/anti-pentraxin-antibodies-in-autoimmune-systemic-diseases-focus-on-anti-pentraxin-3-autoantibodies
#6
Jean-François Augusto, Caroline Poli, Céline Beauvillain, Jean-François Subra, Sebastien Jaillon, Gilles Renier, Alain Chevailler, Xavier Puéchal, Yves Delneste, Pascale Jeannin
Pentraxins are soluble pattern recognition molecules implicated not only in the opsonization and removal of microorganisms but also in the clearance of modified self (i.e., dying cells). Pentraxins can be classified into short pentraxins (C-reactive protein and serum amyloid-P component) and long pentraxins with pentraxin-3 (PTX3), the prototypic one of the latter. Pentraxins are involved in various physiological or pathophysiological processes such as inflammation and autoimmunity. A breakdown in immune tolerance to pentraxins has been reported in various autoimmune diseases...
May 4, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28471251/microrna-22-3p-as-a-novel-regulator-and-therapeutic-target-for-autoimmune-diseases
#7
Bin Wang, Qiuming Yao, Donghua Xu, Jin-An Zhang
MicroRNAs (miRNAs) are a class of noncoding RNAs and have emerged as critical regulators of gene expression. Some miRNAs play important roles in regulating the function of the immune system and are involved in the pathogenesis of autoimmune diseases. Recent studies suggested that microRNA-22-3p (miR-22-3p) was able to regulate the function of several types of immune cells and may be involved in the development of autoimmune diseases. We systematically reviewed relevant literatures to provide a comprehensive review of the possible roles of miR-22-3p in autoimmune diseases...
May 4, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28471248/natural-killer-cells-as-a-promising-tool-to-tackle-cancer-a-review-of-sources-methodologies-and-potentials
#8
Senthilkumar Preethy, Vidyasagar Devaprasad Dedeepiya, Rajappa Senthilkumar, Mathaiyan Rajmohan, Ramalingam Karthick, Hiroshi Terunuma, Samuel J K Abraham
Immune cell-based therapies are emerging as a promising tool to tackle malignancies, both solid tumors and selected hematological tumors. Vast experiences in literature have documented their safety and added survival benefits when such cell-based therapies are combined with the existing treatment options. Numerous methodologies of processing and in vitro expansion protocols of immune cells, such as the dendritic cells, natural killer (NK) cells, NKT cells, αβ T cells, so-called activated T lymphocytes, γδ T cells, cytotoxic T lymphocytes, and lymphokine-activated killer cells, have been reported for use in cell-based therapies...
May 4, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28333574/cytosolic-nucleic-acid-sensors-and-innate-immune-regulation
#9
Daisuke Ori, Motoya Murase, Taro Kawai
During viral and bacterial infections, pathogen-derived cytosolic nucleic acids are recognized by the intracellular RNA sensors retinoic acid-inducible gene I and melanoma-differentiated gene 5 and intracellular DNA sensors, including cyclic-di-GMP-AMP synthase, absent in melanoma 2, interferon (IFN)-gamma inducible protein 16, polymerase III, and so on. Binding of intracellular nucleic acids to these sensors activates downstream signaling cascades, resulting in the production of type I IFNs and pro-inflammatory cytokines to induce appropriate systematic immune responses...
March 23, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28333564/in-this-issue-innate-immunity-and-infectious-diseases-an-update
#10
Himanshu Kumar, Adrian Bot
No abstract text is available yet for this article.
March 23, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28272924/imprinting-of-maternal-thyroid-hormones-in-the-offspring
#11
María Cecilia Opazo, Henny Haensgen, Karen Bohmwald, Luis F Venegas, Helene Boudin, Alvaro A Elorza, Felipe Simon, Carlos Fardella, Susan M Bueno, Alexis M Kalergis, Claudia A Riedel
Thyroid hormones (THs) during pregnancy contribute significantly to cellular differentiation and development in several tissues of the offspring, principally the central nervous system (CNS). TH deficiencies, such as hypothyroidism or hypothyroxinemia, are highly frequent during pregnancy worldwide and known to be detrimental for the development of the fetus. The function of CNS in the offspring gestated under TH deficiency will be irreversible impaired, causing low intellectual quotient, attention deficit, and mental retardation...
March 8, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28272907/emerging-avian-influenza-infections-current-understanding-of-innate-immune-response-and-molecular-pathogenesis
#12
Anamika Mishra, Periyasamy Vijayakumar, Ashwin Ashok Raut
The highly pathogenic avian influenza viruses (HPAIVs) cause severe disease in gallinaceous poultry species, domestic ducks, various aquatic and terrestrial wild bird species as well as humans. The outcome of the disease is determined by complex interactions of multiple components of the host, the virus, and the environment. While the host-innate immune response plays an important role for clearance of infection, excessive inflammatory immune response (cytokine storm) may contribute to morbidity and mortality of the host...
March 8, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28282218/immunotoxins-in-cancer-therapy-review-and-update
#13
Bahman Akbari, Safar Farajnia, Shiva Ahdi Khosroshahi, Fatemeh Safari, Mohammadreza Yousefi, Hassan Dariushnejad, Leila Rahbarnia
Immunotoxins are a novel class of cancer therapeutics that contains a cytotoxic agent fused to a targeting moiety. Various toxic agents from different sources are used in immunotoxin development, including bacterial, plant and human origin cytotoxic elements. Although bacterial and plant-derived toxins are highly toxic and commonly used in immunotoxins, their immunogenicity for human restricted their application in cancer therapy. Here, we discuss the advantages and limitations of bacterial toxins such as Pseudomonas and Diphtheria toxins, plant toxins such as ricin and gelonin, and some endogenous protein of human origin such as RNases and Granzymes...
March 1, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28060562/pathogen-recognition-and-toll-like-receptor-targeted-therapeutics-in-innate-immune-cells
#14
Sarang Tartey, Osamu Takeuchi
The innate immune system deploys a variety of pattern-recognition receptors (PRRs) which include Toll-like receptors (TLRs), RIG-I-like receptors, NOD-like receptors, and C-type lectin receptors to detect the invasion of pathogens and initiate protective responses. The intercellular and intracellular orchestration of signals from different PRRs, their endogenous or microbial ligands and accessory molecules determine the stimulatory or inhibitory responses. Progressing over the last two decades, considerable research on the molecular mechanisms underlying host-pathogen interactions has led to a paradigm shift of our understanding of TLR signaling in the innate immune system...
January 6, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28060559/understanding-the-interaction-between-henipaviruses-and-their-natural-host-fruit-bats-paving-the-way-toward-control-of-highly-lethal-infection-in-humans
#15
François Enchéry, Branka Horvat
Hendra virus and Nipah virus (NiV) are highly pathogenic zoonotic paramyxoviruses, from henipavirus genus, that have emerged in late 1990s in Australia and South-East Asia, respectively. Since their initial identification, numerous outbreaks have been reported, affecting both domestic animals and humans, and multiple rounds of person-to-person NiV transmission were observed. Widely distributed fruit bats from Pteropodidae family were found to be henipavirus natural reservoir. Numerous studies have reported henipavirus seropositivity in pteropid bats, including bats in Africa, thus expanding notably the geographic distribution of these viruses...
January 6, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28215101/in-this-issue-antibodies-in-pathogenesis-and-management-of-diseases
#16
Himanshu Kumar, Adrian Bot
No abstract text is available yet for this article.
January 2, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28215100/targeting-baff-and-april-in-systemic-lupus-erythematosus-and-other-antibody-associated-diseases
#17
Eileen Samy, Stephen Wax, Bertrand Huard, Henry Hess, Pascal Schneider
The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-inducing ligand), are critical factors in the maintenance of the B cell pool and humoral immunity. In addition, BAFF and APRIL are involved in the pathogenesis of a number of human autoimmune diseases, with elevated levels of these cytokines detected in the sera of patients with systemic lupus erythematosus (SLE), IgA nephropathy, Sjögren's syndrome, and rheumatoid arthritis. As such, both molecules are rational targets for new therapies in B cell-driven autoimmune diseases, and several inhibitors of BAFF or BAFF and APRIL together have been investigated in clinical trials...
January 2, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28102734/fibroblast-like-synoviocytes-dependent-effector-molecules-as-a-critical-mediator-for-rheumatoid-arthritis-current-status-and-future-directions
#18
Ramamoorthi Ganesan, Mahaboobkhan Rasool
Rheumatoid arthritis (RA) is a systemic-autoimmune-mediated disease characterized by synovial hyperplasia and progressive destruction of joint. Currently available biological agents and inhibitor therapy that specifically target tumor necrosis factor-α, interleukin 1β (IL-1β), IL-6, T cells, B cells, and subcellular molecules (p38 mitogen-activated protein kinase and janus kinase) cannot facilitate complete remission in all patients and are unable to cure the disease. Therefore, further potent therapeutic targets need to be identified for effective treatment and successful clinical outcomes in patients with RA...
January 2, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28102718/vitamin-d-status-aeroallergen-sensitization-and-allergic-rhinitis-a-systematic-review-and-meta-analysis
#19
Zahra Aryan, Nima Rezaei, Carlos A Camargo
PURPOSE: The role of vitamin D status in the etiology of allergic diseases is uncertain. The aim of this study was to investigate the association of vitamin D status with risk of two main outcomes: aeroallergen sensitization and allergic rhinitis (AR). METHODS: We performed a systematic review of Medline, Scopus, Science Citation Index, and Google Scholar databases. Studies were included if they reported on prevalent or incident cases of aeroallergen sensitization or AR according to vitamin D status...
January 2, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/27739924/broadly-neutralizing-antibodies-an-approach-to-control-hiv-1-infection
#20
Mahmoud Mohammad Yaseen, Mohammad Mahmoud Yaseen, Mohammad Ali Alqudah
Although available antiretroviral therapy (ART) has changed human immunodeficiency virus (HIV)-1 infection to a non-fatal chronic disease, the economic burden of lifelong therapy, severe adverse ART effects, daily ART adherence, and emergence of ART-resistant HIV-1 mutants require prospecting for alternative therapeutic modalities. Indeed, a growing body of evidence suggests that broadly neutralizing anti-HIV-1 antibodies (BNAbs) may offer one such feasible alternative. To evaluate their therapeutic potential in established HIV-1 infection, we sought to address recent advances in pre-clinical and clinical investigations in this area of HIV-1 research...
January 2, 2017: International Reviews of Immunology
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