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Cardiovascular Drugs and Therapy

S Bouchez, F Fedele, G Giannakoulas, F Gustafsson, V-P Harjola, K Karason, M Kivikko, D von Lewinski, F Oliva, Z Papp, J Parissis, Piero Pollesello, G Pölzl, C Tschöpe
Levosimendan, a calcium sensitizer and potassium channel-opener, is widely appreciated by many specialist heart failure practitioners for its effects on systemic and pulmonary hemodynamics and for the relief of symptoms of acute heart failure. The drug's impact on mortality in large randomized controlled trials has been inconsistent or inconclusive but, in contrast to conventional inotropes, there have been no indications of worsened survival and some signals of improved heart failure-related quality of life...
November 6, 2018: Cardiovascular Drugs and Therapy
Yumei Ye, Xiaoming Jia, Mandeep Bajaj, Yochai Birnbaum
PURPOSE: We assessed whether the SGLT-2 inhibitor dapagliflozin (Dapa) attenuates the upregulation of the cardiac Na+ /H+ exchanger (NHE-1) in vitro in mouse cardiofibroblasts stimulated with lipopolysaccharides (LPS) and whether this effect is dependent on adenosine monophosphate kinase (AMPK) activation. METHODS: Mouse cardiofibroblasts were exposed for 16 h to Dapa (0.4 μM), AMPK activator (A769662 (10 μM)), AMPK inhibitor (compound C (CC) (10 μM)), an SGLT-1 and SGLT-2 inhibitor (phlorizin (PZ) (100 μM)), Dapa+CC, or Dapa+PZ, and then stimulated with LPS (10 ng/ml) for 3 h...
October 26, 2018: Cardiovascular Drugs and Therapy
Marco Zuin, Gianluca Rigatelli, Loris Roncon
Over the last years, fentanyl, a potent synthetic μ receptor-stimulating opioid, has become one of the most used drugs for both procedural analgesia and sedation in patients undergoing coronary angiography (CA) and/or percutaneous coronary intervention (PCI). However, few studies have been performed to evaluate the efficacy and the impact of this drug in patients with coronary artery disease (CAD) treated with PCI. Most of the previous studies have investigated the self-reported discomfort pain, demonstrating that patients premedicated with fentanyl generally reported a lower pain/discomfort when compared to placebo, benzodiazepines, or local anesthesia at the site of the artery cannulation, without significant variation in the hemodynamic response...
October 24, 2018: Cardiovascular Drugs and Therapy
Yi Zhou, Huanyuan Wang, Fuli Man, Zhiying Guo, Jiahui Xu, Wenjing Yan, Jiaying Li, Qi Pan, Wen Wang
PURPOSE: The purpose of the study is to identify potential mechanisms involved in the cardiac protective effects of sitagliptin in Zucker diabetic fatty (ZDF) rats. METHODS AND RESULTS: Male non-diabetic lean Zucker rats (Lean) and ZDF rats treated with saline (ZDF) or sitagliptin (ZDF + sita) were used in this study. The blood pressure and lipid profiles were increased significantly in ZDF rats compared with Lean rats. ZDF + sitagliptin rats had decreased systolic blood pressure compared with ZDF rats...
October 16, 2018: Cardiovascular Drugs and Therapy
Venu Gopal Jonnalagadda
No abstract text is available yet for this article.
October 13, 2018: Cardiovascular Drugs and Therapy
Xue Feng, Usha Sambamoorthi, Kim Innes, Gregory Castelli, Traci LeMasters, Lianjie Xiong, Michael U Williams, Xi Tan
PURPOSE: This study aims to evaluate the associations between switching from warfarin to non-vitamin K oral anticoagulants (NOACs), exposure to potential drug-drug interactions (DDIs), and major bleeding events in working-age adults with atrial fibrillation (AF). METHODS: We conducted a retrospective cohort study using the claims database of commercially insured working-age adults with AF from 2010 to 2015. Switchers were defined as patients who switched from warfarin to NOAC; non-switchers were defined as those who remained on warfarin...
October 12, 2018: Cardiovascular Drugs and Therapy
Rosa Ahn, Vinay Prasad
The original version of this article unfortunately contained a mistake. There was a typo in the second sentence of the paragraph under the section Was the Dose of Drugs Fair?; "320 mg twice a day" should read "160mg twice a day". The corrected paragraph is shown below.
October 1, 2018: Cardiovascular Drugs and Therapy
Vasilios Simopoulos, Athanasios Hevas, Apostolia Hatziefthimiou, Konstantina Dipla, Ioannis Skoularigis, Nikolaos Tsilimingas, Isaac Aidonidis
PURPOSE: Ranolazine (RAN) added to amiodarone (AMIO) has been shown to accelerate termination of postoperative atrial fibrillation (POAF) following coronary artery bypass surgery in patients without heart failure (HF). This study aimed to investigate if treatment efficacy with AMIO or AMIO + RAN differs between patients with concomitant HF with reduced or preserved ejection fraction (HFrEF or HFpEF). METHODS: Patients with POAF and HFrEF (n = 511, 446 males; 65 ± 9 years) and with HFpEF (n = 301, 257 males; 66 ± 10 years) were enrolled...
September 25, 2018: Cardiovascular Drugs and Therapy
Spyros D Mentzelopoulos, Iosifina Koliantzaki, Marios Karvouniaris, Charikleia Vrettou, Nicolas Mongardon, George Karlis, Demosthenes Makris, Epaminondas Zakynthinos, Sotirios Sourlas, Stavros Aloizos, Theodoros Xanthos, Spyros G Zakynthinos
The original version of this article unfortunately contained a mistake. In Table 2, the frequency of Septic Shock reported just below the frequency of "At least 1 Episode of VAP" actually corresponds to the First (and not the Second) Episode of VAP during the postresuscitation period.
September 19, 2018: Cardiovascular Drugs and Therapy
Rosa Ahn, Vinay Prasad
No abstract text is available yet for this article.
September 19, 2018: Cardiovascular Drugs and Therapy
Hongxing Luo, Cong Zhang, Juntao Wang, Jialu Zhu, Xingtai Jia
PURPOSE: Previous studies have evaluated intra-study heterogeneities of heart failure with preserved ejection fraction (HFpEF), but inter-study heterogeneities remain poorly understood. We investigate the heterogeneities of outcomes among control groups of HFpEF trials. METHODS: We included randomized controlled trials recruiting HFpEF patients with ejection fraction ≥ 40% and reporting Kaplan-Meier curves for at least 36 months. The Kaplan-Meier curves of control groups were extracted and calculated for hazard ratios and 95% confidence intervals...
September 5, 2018: Cardiovascular Drugs and Therapy
Jianning Zhang, Yijia Shao, Yin Liu, Jun Tao
BACKGROUND: Hypertension and dyslipidemia are major risk factors for cardiovascular disease (CVD). In 2012, over 270 million patients (25.2%) in China were hypertensive and 40.4% was dyslipidemic. The majority of these patients rely on statins for the prevention of cardiovascular disease. However, certain types of statins (e.g., atorvastatin), compared to others (e.g., pitavastatin), may be associated with unfavorable effects on glucose metabolism. This leads to concerns when prescribing statins to patients who also have a predisposition to glucose metabolic disorders (i...
September 5, 2018: Cardiovascular Drugs and Therapy
Paolo Zocca, Marlies M Kok, Liefke C van der Heijden, Peter W Danse, Carl E Schotborgh, Martijn Scholte, Marc Hartmann, Gerard C M Linssen, Carine J M Doggen, Clemens von Birgelen
PURPOSE: Patients with high bleeding risk (HBR) who undergo percutaneous coronary intervention also have an increased risk of ischemic events and represent an overall high-risk population. The coating of durable polymer drug-eluting stents (DP-DES) may induce inflammation and delay arterial healing, which might be reduced by novel biodegradable polymer DES (BP-DES). We aimed to evaluate the safety and efficacy of treating HBR patients with very thin-strut BP-DES versus thin-strut DP-DES...
August 24, 2018: Cardiovascular Drugs and Therapy
Y Eugene Chen
No abstract text is available yet for this article.
October 2018: Cardiovascular Drugs and Therapy
Alexandru Burlacu, Bogdan Artene, Adrian Covic
PURPOSE: A timely pharmacoinvasive strategy consisting of thrombolytic therapy (TT) plays a pivotal role in three major scenarios: acute ischemic stroke (AIS), acute myocardial infarction (STEMI), and massive pulmonary embolism (PE). Presence of advanced chronic kidney disease (CKD) (estimated glomerular filtration rate < 30 mL/min/1.73 m2), known to disturb thrombotic/thrombolytic equilibrium, causes difficulties for clinicians in evaluating risk-benefit balance, as current guidelines do not address the relationship between TT and the advanced CKD...
October 2018: Cardiovascular Drugs and Therapy
Irene Del Canto, Laura Santamaría, Patricia Genovés, Luis Such-Miquel, Oscar Arias-Mutis, Manuel Zarzoso, Carlos Soler, Germán Parra, Álvaro Tormos, Antonio Alberola, Luis Such, Francisco J Chorro
PURPOSE: Mechanical stretch increases sodium and calcium entry into myocytes and activates the late sodium current. GS967, a triazolopyridine derivative, is a sodium channel blocker with preferential effects on the late sodium current. The present study evaluates whether GS967 inhibits or modulates the arrhythmogenic electrophysiological effects of myocardial stretch. METHODS: Atrial and ventricular refractoriness and ventricular fibrillation modifications induced by acute stretch were studied in Langendorff-perfused rabbit hearts (n = 28) using epicardial multiple electrodes and high-resolution mapping techniques under control conditions and during the perfusion of GS967 at different concentrations (0...
October 2018: Cardiovascular Drugs and Therapy
Chak Kwong Cheng, Hamidah Abu Bakar, Maik Gollasch, Yu Huang
Perivascular adipose tissue (PVAT) refers to the local aggregate of adipose tissue surrounding the vascular tree, exhibiting phenotypes from white to brown and beige adipocytes. Although PVAT has long been regarded as simply a structural unit providing mechanical support to vasculature, it is now gaining reputation as an integral endocrine/paracrine component, in addition to the well-established modulator endothelium, in regulating vascular tone. Since the discovery of anti-contractile effect of PVAT in 1991, the use of multiple rodent models of reduced amounts of PVAT has revealed its regulatory role in vascular remodeling and cardiovascular implications, including atherosclerosis...
October 2018: Cardiovascular Drugs and Therapy
Jose C Nicolau, Remo H M Furtado, Luciano M Baracioli, Livia M Lara, Talia F Dalçóquio, Marco A Scanavini Junior, César A C Pereira, Viviane M Lima, Talita M Gonçalves, Raíza Colodetti, Aline G Ferrari, Renato D Lopes, Robert P Giugliano
BACKGROUND: The role of beta-blockers in patients with acute coronary syndromes is mainly derived from studies including patients with ST-segment elevation myocardial infarction. Little is known about the use of beta-blockers and associated long-term clinical outcomes in patients with non-ST-elevation acute coronary syndromes (NSTEACS). METHODS: We analyzed short- and long-term clinical outcomes of 2921 patients with NSTEACS using or not oral beta-blockers in the first 24 h of the acute coronary syndromes (ACS) presentation...
October 2018: Cardiovascular Drugs and Therapy
Sebastian Bunte, Friederike Behmenburg, Anton Bongartz, Martin Stroethoff, Annika Raupach, André Heinen, Jan-Philipp Minol, Markus W Hollmann, Ragnar Huhn, Stephan U Sixt
PURPOSE: Activation of mitochondrial large-conductance Ca2+ -sensitive potassium (mBKCa )-channels is a crucial step for cardioprotection by preconditioning. Whether activation of these channels is involved in levosimendan-induced preconditioning is unknown. We investigated if cardioprotection by levosimendan requires activation of mBKCa -channels in the rat heart in vitro. METHODS: In a prospective blinded experimental laboratory investigation, hearts of male Wistar rats were randomized and placed on a Langendorff system, perfused with Krebs-Henseleit buffer at a constant pressure of 80 mmHg...
October 2018: Cardiovascular Drugs and Therapy
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