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Cardiovascular Drugs and Therapy

Spyros D Mentzelopoulos, Iosifina Koliantzaki, Marios Karvouniaris, Charikleia Vrettou, Nicolas Mongardon, George Karlis, Demosthenes Makris, Epaminondas Zakynthinos, Sotirios Sourlas, Stavros Aloizos, Theodoros Xanthos, Spyros G Zakynthinos
The original version of this article unfortunately contained a mistake. In Table 2, the frequency of Septic Shock reported just below the frequency of "At least 1 Episode of VAP" actually corresponds to the First (and not the Second) Episode of VAP during the postresuscitation period.
September 19, 2018: Cardiovascular Drugs and Therapy
Rosa Ahn, Vinay Prasad
No abstract text is available yet for this article.
September 19, 2018: Cardiovascular Drugs and Therapy
Alexandru Burlacu, Bogdan Artene, Adrian Covic
PURPOSE: A timely pharmacoinvasive strategy consisting of thrombolytic therapy (TT) plays a pivotal role in three major scenarios: acute ischemic stroke (AIS), acute myocardial infarction (STEMI), and massive pulmonary embolism (PE). Presence of advanced chronic kidney disease (CKD) (estimated glomerular filtration rate < 30 mL/min/1.73 m2), known to disturb thrombotic/thrombolytic equilibrium, causes difficulties for clinicians in evaluating risk-benefit balance, as current guidelines do not address the relationship between TT and the advanced CKD...
September 5, 2018: Cardiovascular Drugs and Therapy
Hongxing Luo, Cong Zhang, Juntao Wang, Jialu Zhu, Xingtai Jia
PURPOSE: Previous studies have evaluated intra-study heterogeneities of heart failure with preserved ejection fraction (HFpEF), but inter-study heterogeneities remain poorly understood. We investigate the heterogeneities of outcomes among control groups of HFpEF trials. METHODS: We included randomized controlled trials recruiting HFpEF patients with ejection fraction ≥ 40% and reporting Kaplan-Meier curves for at least 36 months. The Kaplan-Meier curves of control groups were extracted and calculated for hazard ratios and 95% confidence intervals...
September 5, 2018: Cardiovascular Drugs and Therapy
Jianning Zhang, Yijia Shao, Yin Liu, Jun Tao
BACKGROUND: Hypertension and dyslipidemia are major risk factors for cardiovascular disease (CVD). In 2012, over 270 million patients (25.2%) in China were hypertensive and 40.4% was dyslipidemic. The majority of these patients rely on statins for the prevention of cardiovascular disease. However, certain types of statins (e.g., atorvastatin), compared to others (e.g., pitavastatin), may be associated with unfavorable effects on glucose metabolism. This leads to concerns when prescribing statins to patients who also have a predisposition to glucose metabolic disorders (i...
September 5, 2018: Cardiovascular Drugs and Therapy
Irene Del Canto, Laura Santamaría, Patricia Genovés, Luis Such-Miquel, Oscar Arias-Mutis, Manuel Zarzoso, Carlos Soler, Germán Parra, Álvaro Tormos, Antonio Alberola, Luis Such, Francisco J Chorro
PURPOSE: Mechanical stretch increases sodium and calcium entry into myocytes and activates the late sodium current. GS967, a triazolopyridine derivative, is a sodium channel blocker with preferential effects on the late sodium current. The present study evaluates whether GS967 inhibits or modulates the arrhythmogenic electrophysiological effects of myocardial stretch. METHODS: Atrial and ventricular refractoriness and ventricular fibrillation modifications induced by acute stretch were studied in Langendorff-perfused rabbit hearts (n = 28) using epicardial multiple electrodes and high-resolution mapping techniques under control conditions and during the perfusion of GS967 at different concentrations (0...
September 1, 2018: Cardiovascular Drugs and Therapy
Chak Kwong Cheng, Hamidah Abu Bakar, Maik Gollasch, Yu Huang
Perivascular adipose tissue (PVAT) refers to the local aggregate of adipose tissue surrounding the vascular tree, exhibiting phenotypes from white to brown and beige adipocytes. Although PVAT has long been regarded as simply a structural unit providing mechanical support to vasculature, it is now gaining reputation as an integral endocrine/paracrine component, in addition to the well-established modulator endothelium, in regulating vascular tone. Since the discovery of anti-contractile effect of PVAT in 1991, the use of multiple rodent models of reduced amounts of PVAT has revealed its regulatory role in vascular remodeling and cardiovascular implications, including atherosclerosis...
August 31, 2018: Cardiovascular Drugs and Therapy
Paolo Zocca, Marlies M Kok, Liefke C van der Heijden, Peter W Danse, Carl E Schotborgh, Martijn Scholte, Marc Hartmann, Gerard C M Linssen, Carine J M Doggen, Clemens von Birgelen
PURPOSE: Patients with high bleeding risk (HBR) who undergo percutaneous coronary intervention also have an increased risk of ischemic events and represent an overall high-risk population. The coating of durable polymer drug-eluting stents (DP-DES) may induce inflammation and delay arterial healing, which might be reduced by novel biodegradable polymer DES (BP-DES). We aimed to evaluate the safety and efficacy of treating HBR patients with very thin-strut BP-DES versus thin-strut DP-DES...
August 24, 2018: Cardiovascular Drugs and Therapy
Jose C Nicolau, Remo H M Furtado, Luciano M Baracioli, Livia M Lara, Talia F Dalçóquio, Marco A Scanavini Junior, César A C Pereira, Viviane M Lima, Talita M Gonçalves, Raíza Colodetti, Aline G Ferrari, Renato D Lopes, Robert P Giugliano
BACKGROUND: The role of beta-blockers in patients with acute coronary syndromes is mainly derived from studies including patients with ST-segment elevation myocardial infarction. Little is known about the use of beta-blockers and associated long-term clinical outcomes in patients with non-ST-elevation acute coronary syndromes (NSTEACS). METHODS: We analyzed short- and long-term clinical outcomes of 2921 patients with NSTEACS using or not oral beta-blockers in the first 24 h of the acute coronary syndromes (ACS) presentation...
August 20, 2018: Cardiovascular Drugs and Therapy
Sebastian Bunte, Friederike Behmenburg, Anton Bongartz, Martin Stroethoff, Annika Raupach, André Heinen, Jan-Philipp Minol, Markus W Hollmann, Ragnar Huhn, Stephan U Sixt
PURPOSE: Activation of mitochondrial large-conductance Ca2+ -sensitive potassium (mBKCa )-channels is a crucial step for cardioprotection by preconditioning. Whether activation of these channels is involved in levosimendan-induced preconditioning is unknown. We investigated if cardioprotection by levosimendan requires activation of mBKCa -channels in the rat heart in vitro. METHODS: In a prospective blinded experimental laboratory investigation, hearts of male Wistar rats were randomized and placed on a Langendorff system, perfused with Krebs-Henseleit buffer at a constant pressure of 80 mmHg...
August 17, 2018: Cardiovascular Drugs and Therapy
Joshua M Boucher, Michael Robich, S Spencer Scott, Xuehui Yang, Larisa Ryzhova, Jacqueline E Turner, Ilka Pinz, Lucy Liaw
PURPOSE: Perivascular adipose tissue (PVAT) surrounds blood vessels and regulates vascular tone through paracrine secretion of cytokines. During conditions promoting cardiometabolic dysfunction, such as obesity, cytokine secretion is altered towards a proinflammatory and proatherogenic profile. Despite the clinical implications for cardiovascular disease, studies addressing the biology of human PVAT remain limited. We are interested in characterizing the resident adipose progenitor cells (APCs) because of their potential role in PVAT expansion during obesity...
August 13, 2018: Cardiovascular Drugs and Therapy
Tetsuo Horimatsu, Aaron S Patel, Rosaria Prasad, Lauren E Reid, Tyler W Benson, Abdalrahman Zarzour, Mourad Ogbi, Thiago Bruder do Nascimento, Eric Belin de Chantemele, Brian K Stansfield, Xin-Yun Lu, Ha Won Kim, Neal L Weintraub
PURPOSE: Perivascular adipose tissue (PVAT) surrounds the arterial adventitia and plays an important role in vascular homeostasis. PVAT expands in obesity, and inflamed PVAT can locally promote endothelial dysfunction and atherosclerosis. Here, using adipose tissue transplantation, we tested the hypothesis that expansion of PVAT can also remotely exacerbate vascular disease. METHODS: Fifty milligrams of abdominal aortic PVAT was isolated from high-fat diet (HFD)-fed wild-type mice and transplanted onto the abdominal aorta of lean LDL receptor knockout mice...
August 10, 2018: Cardiovascular Drugs and Therapy
Gennaro Giustino, Lisandro D Colantonio, Todd M Brown, April P Carson, Yuling Dai, Michael E Farkouh, Keri L Monda, Paul Muntner, Robert S Rosenson
BACKGROUND: Patients with diabetes mellitus (DM) have a high risk for cardiovascular disease (CVD) events after an acute myocardial infarction (AMI). High-intensity statins reduce CVD risk following AMI among patients with and without DM. METHODS: We determined the proportion of Medicare beneficiaries 66 to 75 years of age taking a low/moderate-intensity statin with (n = 6718) and without (n = 6414) DM who titrated to a high-intensity statin dosage (i.e...
August 4, 2018: Cardiovascular Drugs and Therapy
Robert S Rosenson, Qinzhong Chen, Sherwin D Najera, Martin L Lee, Daniel J Cho
BACKGROUND: Lower extremity arterial disease (LEAD) occurs more common in patients with diabetes than without diabetes. Microvascular complications of diabetes contribute to higher rates of adverse limb events in patients with LEAD. Blood flow in the macrocirculation and microcirculation is reduced with increasing low-shear and high-shear blood viscosity. We hypothesize that the adenosine enhancing properties of ticagrelor will reduce low-shear blood viscosity and improve microcirculatory flow in the dorsum of the feet of patients with type 2 diabetes...
August 3, 2018: Cardiovascular Drugs and Therapy
Xiao-Xi Pan, Jiu-Mei Cao, Fan Cai, Cheng-Chao Ruan, Fang Wu, Ping-Jin Gao
PURPOSE: Pathological changes of the perivascular adipose tissue (PVAT) are directly associated with increased risk of age-related vascular diseases. MicroRNAs regulate adipocyte biological functions including adipogenic differentiation and white adipocyte browning. The present study aims to determine whether miR-146b-3p is involved in the regulation of perivascular adipocyte browning during aging. METHODS: We utilized a cold-induced animal model to investigate the effect of aging on perivascular adipocyte browning...
August 2, 2018: Cardiovascular Drugs and Therapy
Lin Chang, Xiangjie Zhao, Minerva Garcia-Barrio, Jifeng Zhang, Y Eugene Chen
PURPOSE: Arterial stiffness is an inevitable consequence of the aging process and is considered an early stage in the development of cardiovascular diseases. The perivascular adipose tissue (PVAT) is a distinct functional integral layer of the vasculature actively involved in blood pressure regulation and atherosclerosis development via PVAT-derived paracrine/autocrine factors. However, there is little knowledge regarding the relationship between PVAT and arterial stiffness. METHODS: Using unique mice lacking PVAT, high-fat diet-induced obesity, and in mice overexpressing brown adipocyte selective mitoNEET, we investigated the relationship between PVAT and arterial stiffness in mice...
July 18, 2018: Cardiovascular Drugs and Therapy
D Lanéelle, O Stivalet, G Mahé, V Jaquinandi, L Omarjee
No abstract text is available yet for this article.
July 9, 2018: Cardiovascular Drugs and Therapy
Spyros D Mentzelopoulos, Iosifina Koliantzaki, Marios Karvouniaris, Charikleia Vrettou, Nicolas Mongardon, George Karlis, Demosthenes Makris, Epaminondas Zakynthinos, Sotirios Sourlas, Stavros Aloizos, Theodoros Xanthos, Spyros G Zakynthinos
PURPOSE: Low-dose steroids may reduce the mortality of severely ill patients with septic shock. We sought to determine whether exposure to stress-dose steroids during and/or after cardiopulmonary resuscitation is associated with reduced risk of death due to postresuscitation septic shock. METHODS: We analyzed pooled, individual patient data from two prior, randomized clinical trials (RCTs). RCTs evaluated vasopressin, steroids, and epinephrine (VSE) during resuscitation and stress-dose steroids after resuscitation in vasopressor-requiring, in-hospital cardiac arrest...
August 2018: Cardiovascular Drugs and Therapy
Tobias Schupp, Michael Behnes, Christel Weiß, Christoph Nienaber, Siegfried Lang, Linda Reiser, Armin Bollow, Gabriel Taton, Thomas Reichelt, Dominik Ellguth, Niko Engelke, Uzair Ansari, Ibrahim El-Battrawy, Thomas Bertsch, Muharrem Akin, Kambis Mashayekhi, Martin Borggrefe, Ibrahim Akin
OBJECTIVE: The study sought to assess the impact of treatment with beta-blocker (BB) or ACE inhibitor/angiotensin receptor blocker (ACEi/ARB) on secondary survival in patients presenting with ventricular tachyarrhythmia. BACKGROUND: Data regarding outcome of patients presenting with ventricular tachyarrhythmia treated with BB and ACEi/ARB is limited. METHODS: A large retrospective registry was used including consecutive patients presenting with ventricular tachycardia and fibrillation from 2002 to 2016 on admission...
August 2018: Cardiovascular Drugs and Therapy
Leslie Cho, Ricardo Dent, Erik S G Stroes, Evan A Stein, David Sullivan, Andrea Ruzza, Andrea Flower, Ransi Somaratne, Robert S Rosenson
PURPOSE: Evolocumab reduced low-density lipoprotein cholesterol (LDL-C) in 12-week trials in statin-intolerant patients (GAUSS-1 and GAUSS-2); however, the persistence of efficacy during longer-term treatment is unknown. This subset analysis of the open-label extension studies (OSLER-1 and OSLER-2) aimed to evaluate the safety and efficacy of evolocumab up to 2 years in statin-intolerant patients. METHODS: Patients who completed GAUSS-1 and GAUSS-2 were enrolled in the OSLER studies and rerandomized 2:1 to evolocumab (140 mg biweekly or 420 mg monthly) plus standard of care (SOC) or SOC during year 1, and thereafter, evolocumab plus SOC...
August 2018: Cardiovascular Drugs and Therapy
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