Azka Anwar, Fahim Ullah Khan, Waqar Younas, Muhib Zaman, Muhammad Noorullah, Li'ang Li, Amina Zuberi, Youji Wang
Considering the wide application of nanoparticles in various fields of life and growing concern regarding their toxic effects, the present study was designed with the aim to evaluate the potential risks of using copper sulfate nanoparticles (CuSO4 -NPs) in comparison to bulk form. Nanoparticles of CuSO4 , having mean size of 73 nm were prepared by ball milling method, and fingerlings of Labeo rohita were exposed to two levels, 20 and 100 μg L-1 of CuSO4 in both bulk and nano forms for 28 days and their comparative effects on the metallothioneins (MTs), heat shock proteins 70 (HSP 70), lipid profile, cholesterol (CHOL) and triglyceraldehyde (TG) levels, activities of some metabolic enzymes Alanine transaminase (ALT), Aspartate transaminase (AST) Akaline phosphatase (ALP), and genes expressions of HSP-70, TNF-α and IL1-ß were investigated...
December 15, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA