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Journals Toxicology in Vitro : An Inter...

Toxicology in Vitro : An International Journal Published in Association with BIBRA

https://read.qxmd.com/read/38219805/estiv-2022-key-enabling-non-animal-technologies-for-research-education-and-testing
#21
EDITORIAL
Helena Kandarova, Clive Roper, Marketa Dvořáková
No abstract text is available yet for this article.
January 12, 2024: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38199585/particulate-iron-oxide-food-colorants-e-172-during-artificial-digestion-and-their-uptake-and-impact-on-intestinal-cells
#22
JOURNAL ARTICLE
Holger Sieg, Caroline Schaar, Nicole Fouquet, Linda Böhmert, Andreas F Thünemann, Albert Braeuning
Iron oxide of various structures is frequently used as food colorant (E 172). The spectrum of colors ranges from yellow over orange, red, and brown to black, depending on the chemical structure of the material. E 172 is mostly sold as solid powder. Recent studies have demonstrated the presence of nanoscaled particles in E 172 samples, often to a very high extent. This makes it necessary to investigate the fate of these particles after oral uptake. In this study, 7 differently structured commercially available E 172 food colorants (2 x Yellow FeO(OH), 2 x Red Fe2 O3 , 1 x Orange Fe2 O3  + FeO(OH) and 2 x Black Fe3 O4 ) were investigated for particle dissolution, ion release, cellular uptake, crossing of the intestinal barrier and toxicological impact on intestinal cells...
January 8, 2024: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38182034/protective-role-of-fetal-bovine-serum-on-plhc-1-spheroids-exposed-to-a-mixture-of-plastic-additives-a-lipidomic-perspective
#23
JOURNAL ARTICLE
Tiantian Wang, Judith Desmet, Cinta Porte
The use of fetal bovine serum (FBS) in cell culture is being questioned for scientific and ethical reasons, prompting the exploration of alternative approaches. Nevertheless, the influence of FBS on cell functioning, especially in fish cells, has not been comprehensively examined. This study aims to evaluate the impact of FBS on the lipidome of PLHC-1 spheroids and investigate cellular and molecular responses to plastic additives in the presence/absence of FBS. Lipidomic analyses were conducted on PLHC-1 cell spheroids using liquid chromatography coupled with a high-resolution quadrupole time-of-flight mass spectrometer (HRMS-QToF)...
January 3, 2024: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38151217/screening-for-endocrine-disrupting-chemicals-inhibiting-monocarboxylate-8-mct8-transporter-facilitated-thyroid-hormone-transport-using-a-modified-nonradioactive-assay
#24
JOURNAL ARTICLE
Fabian Wagenaars, Peter Cenijn, Martin Scholze, Caroline Frädrich, Kostja Renko, Josef Köhrle, Timo Hamers
Early neurodevelopmental processes are strictly dependent on spatial and temporally modulated of thyroid hormone (TH) availability and action. Thyroid hormone transmembrane transporters (THTMT) are critical for regulating the local concentrations of TH, namely thyroxine (T4) and 3,5,3'-tri-iodothyronine (T3), in the brain. Monocarboxylate transporter 8 (MCT8) is one of the most prominent THTMT. Genetically induced deficiencies in expression, function or localization of MCT8 are associated with irreversible and severe neurodevelopmental adversities...
December 25, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38142785/fragrances-as-a-trigger-of-immune-responses-in-different-environments
#25
REVIEW
M Macchione, K Yoshizaki, D P Frias, K Maier, J Smelan, C M Prado, T Mauad
Fragrances can cause allergic skin reactions, expressed as allergic contact dermatitis and reactions in the respiratory tract that range from acute temporary upper airway irritation to obstructive lung disease. These adverse health effects may result from the stimulation of a specific (adaptive) immune response. Th1 cells, which essentially produce interleukin-2 (IL-2) and interferon-γ (IFN-γ), play a key role in allergic contact dermatitis and also on allergic sensitization to common allergens (e...
December 22, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38142784/comparison-of-in-vitro-thyroxine-t4-metabolism-between-wistar-rat-and-human-hepatocyte-cultures
#26
JOURNAL ARTICLE
Audrey Baze, Lucille Wiss, Liliia Horbal, Klaus Biemel, Laure Asselin, Lysiane Richert
In vitro assays remain relatively new in exploring human relevance of liver-, in particular nuclear receptor-mediated perturbations of the hypothalamus-pituitary-thyroid axis seen in rodents, mainly in the rat. Consistent with in vivo data, we confirm that thyroid hormone thyroxine metabolism was 9 times higher in primary rat hepatocytes (PRH) than in primary human hepatocytes (PHH) cultured in a 2D sandwich configuration. In addition, thyroxine glucuronide (T4-G) was by far the major metabolite formed in both species (99...
December 22, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38135130/dinaciclib-inhibits-the-growth-of-acute-myeloid-leukemia-cells-through-either-cell-cycle-related-or-erk1-stat3-myc-pathways
#27
JOURNAL ARTICLE
Chieh-Lin Jerry Teng, Pang-Ting Cheng, Yu-Chiao Cheng, Jia-Rung Tsai, Mei-Chih Chen, Ho Lin
Although immature differentiation and uncontrolled proliferation of hematopoietic stem cells are thought to be the primary mechanisms of acute myeloid leukemia (AML), the pathophysiology in most cases remains unclear. Dinaciclib, a selective small molecule targeting multiple cyclin-dependent kinases (CDKs), is currently being evaluated in oncological clinical trials. Despite the proven anticancer potential of dinaciclib, the differential molecular mechanisms by which it inhibits the growth of different AML cell lines remain unclear...
December 20, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38122908/delayed-clearance-of-the-pro-carcinogen-benzo-a-pyrene-in-plhc-1-cells-when-co-exposed-to-the-antifungal-drug-clotrimazole-and-effects-on-the-cyp1a-biomarker
#28
JOURNAL ARTICLE
Maja Edenius, Anne Farbrot, Anders Blom, Malin C Celander
Cytochrome P450 1 A (CYP1A) is a key enzyme in the metabolism of the polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BaP) in animals, and a biomarker for environmental PAH exposure. The common antimycotic imidazole drug clotrimazole (CLO) has been detected in the aquatic environment and likely co-exists with BaP. Like BaP, CLO can bind to CYP1A enzymes and can act as a CYP1A inhibitor. Co-exposure of BaP with CLO significantly delayed BaP elimination in a fish liver cell line (PLHC-1). Intracellular BaP concentration was 2...
December 18, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38104743/reduced-toxic-effects-of-nano%C3%A2-copper-sulfate-in-comparison-of-bulk-cuso-4-on-biochemical-parameters-in-the-rohu-labeo-rohita
#29
JOURNAL ARTICLE
Azka Anwar, Fahim Ullah Khan, Waqar Younas, Muhib Zaman, Muhammad Noorullah, Li'ang Li, Amina Zuberi, Youji Wang
Considering the wide application of nanoparticles in various fields of life and growing concern regarding their toxic effects, the present study was designed with the aim to evaluate the potential risks of using copper sulfate nanoparticles (CuSO4 -NPs) in comparison to bulk form. Nanoparticles of CuSO4 , having mean size of 73 nm were prepared by ball milling method, and fingerlings of Labeo rohita were exposed to two levels, 20 and 100 μg L-1 of CuSO4 in both bulk and nano forms for 28 days and their comparative effects on the metallothioneins (MTs), heat shock proteins 70 (HSP 70), lipid profile, cholesterol (CHOL) and triglyceraldehyde (TG) levels, activities of some metabolic enzymes Alanine transaminase (ALT), Aspartate transaminase (AST) Akaline phosphatase (ALP), and genes expressions of HSP-70, TNF-α and IL1-ß were investigated...
December 15, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38103703/synthesis-of-homogeneous-spherical-selenium-nanoparticles-through-a-chemical-method-for-cancer-therapy-applications
#30
JOURNAL ARTICLE
E I Adam-Dima, M Balaș, M Anastasescu, C Purdel, D Margină
Oxidative stress is associated with pathologies affecting various organs or metabolic pathways. Thus, targeting oxidative stress might represent a valid therapeutic option. Selenium nanoparticles (SeNPs) are reported to exert antioxidant effects by many mechanisms. Our purpose was to assess in vitro on normal (MRC-5) and cancer (PANC-1) cell lines the potential of SeNPs for inducing cytotoxicity and redox modulation. They were synthesized through a chemogenic method and characterized through advanced microscopy techniques...
December 14, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38101492/organochlorine-pesticides-disrupt-t-helper-cell-regulation-and-reduce-il-2-and-ifn-%C3%AE-favoring-infection-and-production-of-autoantibodies-among-pemphigus-patients
#31
JOURNAL ARTICLE
Sajad Ahmad Dar, Shukla Das, Mohammed Ageeli Hakami, Naseem Akhter, Mohammad Mustafa, Arshad Jawed, Sambit Nath Bhattacharya, Basu Dev Banerjee, Abrar Ahmad
The list of environmental factors that trigger autoimmune diseases in genetically susceptible individuals has grown in the recent years and is far from complete. The possible intervention of the environment in triggering these diseases is ever more perceived by the clinicians. This study investigated the effect of environmental factors like organochlorine pesticides (OCPs) on proportions of different T lymphocyte subsets and their cytokine secretion in-vitro among pemphigus patients, before and after specific immunosuppressive therapy...
December 13, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38081393/investigating-the-dependency-of-in-vitro-benchmark-concentrations-on-exposure-time-in-transcriptomics-experiments
#32
JOURNAL ARTICLE
Donatella Carpi, Roman Liska, Julia M Malinowska, Taina Palosaari, Mounir Bouhifd, Maurice Whelan
There is increasing interest to employ in vitro transcriptomics experiments in toxicological testing, for example to determine a point-of-departure (PoD) for chemical safety assessment. However current practices to derive PoD tend to utilise single exposure time-despite the importance of exposure time on the manifestation of toxicity caused by a chemical. It is important therefore to investigate both concentration and exposure time to determine how these factors affect biological responses, and as a consequence, the derivation of PoDs...
December 9, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38072180/in-vitro-screening-of-per-and-polyfluorinated-substances-pfas-for-interference-with-seven-thyroid-hormone-system-targets-across-nine-assays
#33
JOURNAL ARTICLE
Sigmund J Degitz, Jennifer H Olker, Jeffrey, S Denny, Philip P Degoey, Phillip C Hartig, Mary C Cardon, Stephanie A Eytcheson, Jonathan T Haselman, Sally A Mayasich, Michael W Hornung
The US Environmental Protection Agency is evaluating the ecological and toxicological effects of per- and polyfluorinated chemicals. A number of perfluorinated chemicals have been shown to impact the thyroid axis in vivo suggesting that the thyroid hormone system is a target of these chemicals. The objective of this study was to evaluate the activity of 136 perfluorinated chemicals at seven key molecular initiating events (MIE) within the thyroid axis using nine in vitro assays. The potential MIE targets investigated are Human Iodothyronine Deiodinase 1 (hDIO1), Human Iodothyronine Deiodinase 2 (hDIO2), Human Iodothyronine Deiodinase 3 (hDIO3), Xenopus Iodothyronine Deiodinase (xDIO3); Human Iodotyrosine Deiodinase (hIYD), Xenopus Iodotyrosine Deiodinase (xIYD), Human Thyroid Peroxidase (hTPO); and the serum binding proteins Human Transthyretin (hTTR) and Human Thyroxine Binding Globulin (hTBG)...
December 8, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38070718/comparative-studies-on-the-cytotoxic-effects-induced-by-iron-oxide-nanoparticles-in-cancerous-and-noncancerous-human-lung-cells-subjected-to-an-alternating-magnetic-field
#34
JOURNAL ARTICLE
Monika Ruzycka-Ayoush, Kamil Sobczak, Ireneusz P Grudzinski
The cytotoxic effects of water-based ferrofluids composed of iron oxide nanoparticles, including magnetite (Fe3 O4 ) and maghemite (γ-Fe2 O3 ), ranging from 15 to 100 nm, were examined on various lung cancer cells including adenocarcinomic human alveolar basal epithelial cells (A549), nonsmall lung squamous cell carcinoma (H1703), small cell lung cancer cells (DMS 114), and normal bronchial epithelial cells (BEAS-2B). The cytotoxic effect was evaluated both with and without exposure to an alternating magnetic field (AMF)...
December 7, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38061605/changes-in-attachment-and-metabolic-activity-of-rat-neonatal-cardiomyocytes-and-nonmyocytes-caused-by-macrovipera-lebetina-obtusa-venom
#35
JOURNAL ARTICLE
Hovhannes Arestakesyan, Narine LeFevre, Nikki Posnack, Arni Sarian, Vahan Grigorian, Naira Ayvazyan, Armen Voskanyan, Narine Sarvazyan, Zaruhi Karabekian
The Caucasian viper Macrovipera lebetina obtusa (MLO) is one of the most prevalent and venomous snakes in the Caucasus and the surrounding regions, yet the effects of MLO venom on cardiac function remain largely unknown. We examined the influence of MLO venom (crude and with inhibited metalloproteinases and phospholipase A2 ) on attachment and metabolic activity of rat neonatal cardiomyocytes (CM) and nonmyocytes (nCM), assessed at 1 and 24 h. After exposing both CM and nCM to varying concentrations of MLO venom, we observed immediate cytotoxic effects at a concentration of 100 μg/ml, causing detachment from the culture substrate...
December 5, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38061604/nilotinib-exhibits-less-toxicity-than-imatinib-and-influences-the-immune-state-by-modulating-inos-p-p38-and-p-jnk-in-lps-ifn-gamma-activated-macrophages
#36
JOURNAL ARTICLE
Arzu Zeynep Karabay, Tulin Ozkan, Asli Koc, Yalda Hekmatshoar, A Selen Gurkan-Alp, Asuman Sunguroglu
In this study, we aimed to analyze the effects of first and second-generation Bcr-Abl tyrosine kinase inhibitors, imatinib and nilotinib on LPS/IFN gamma activated RAW 264.7 macrophages. Our data revealed that imatinib was less effective on nitrite levels and more toxic on macrophages compared to nilotinib. Therefore, we further analysed the effect of nilotinib on various inflammatory markers including iNOS, COX-2, NFkB, IL-6, p-ERK, p-p38 and p-JNK in LPS/IFN gamma activated RAW264.7 macrophages. Spectrophotometric viability test and Griess assay,western blot, RT-PCR and luciferase reporter assays were used to analyze the biological activity of nilotinib...
December 5, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38061603/betulinic-acid-inhibits-the-proliferation-of-human-laryngeal-carcinoma-cells-through-reactive-oxygen-species-mediate-mitochondrial-apoptotic-pathway
#37
JOURNAL ARTICLE
Huamin Zhang, Mengru Zhou, Chongtao Ye, Jiahao Qin, Xuan Lu, Chunyan Wang, Xude Wang, Xuejun Jin
Betulinic acid (BA), a natural pentacyclic triterpene, was extracted from the white birch tree, Triphyophyllum peltatum and the jujube tree. In a variety of human cancer cell lines, this substance displays anticancer properties. In this study, we examined how BA works to inhibit human laryngeal cancer growth. We discovered that BA minimally exhibited cytotoxicity in normal cells (human normal cell line GES-1), while remarkably inhibiting viability of AMC-HN-8, TU212, HEp-2 and M4e cells in a concentration-dependent manner...
December 5, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38061602/the-mechanism-of-anticancer-effects-of-some-pyrrolopyrimidine-derivatives-on-ht-29-human-colon-cancer-cells
#38
JOURNAL ARTICLE
Mustafa Ergul, Zuhal Kilic-Kurt, Yeliz Aka, Ozgur Kutuk, Zeynep Deniz Şahin İnan
In the present work, mechanism of anticancer activity of some pyrrolopyrimidine derivatives was evaluated. Compounds 5 and 8 exhibiting significant antiproliferative activity against HT-29 cells with IC50 values of 4.17 μM and 2.96, arrested the cells at the G2/M phase and significantly induced apoptosis. The apoptotic potential of the compounds has been verified via ELISA assay, which resulted in increased BAX, PUMA, BIM, and cleaved caspase 3 expression and decreased BCL-XL and MCL-1 protein levels in HT-29 cells...
December 5, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38043628/mettl3-regulates-fam83d-m-6-a-modification-to-accelerate-tumorigenesis-of-triple-negative-breast-cancer-via-the-wnt-%C3%AE-catenin-pathway
#39
JOURNAL ARTICLE
Xiaodong Yu, Yaxun Li, Fanshuang Kong, Qun Xu
N6-methyladenosine (m6 A) modification, the most abundant methylation modification on eukaryotic mRNAs, was implicated in the tumourigenesis. This study aimed to explore the role of methyltransferase like 3 (METTL3) in triple-negative breast cancer progression and its underlying mechanisms. FAM83D was markedly elevated in triple-negative breast cancer tissues and cells, and high expression of FAM83D was related to the poor prognosis of triple-negative breast cancer patients. FAM83D knockdown significantly retarded cell proliferation, invasion, stemness, and accelerated cell apoptosis in triple-negative breast cancer cells...
December 1, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38043627/a-multiparametric-and-orthogonal-approach-indicates-low-toxicity-for-zein-nanoparticles-in-a-repellent-formulation
#40
JOURNAL ARTICLE
Tuanny Leite Almeida, Aline Francisca Moreira, Jhones Luiz de Oliveira, Carolina Barbara Rogerio, Samara Flamini Kiihl, Leonardo Fernandes Fraceto, Marcelo Bispo de Jesus
The incidence of viruses such as Zika, Dengue, and Chikungunya affects human health worldwide, and insect repellents are recommended for individual protection. Formulations incorporating nanotechnology should be carefully assessed for toxicity, particularly regarding the security levels established for human health and the environment. This study evaluates the cytotoxicity of a repellent formulation containing zein nanoparticles (NP) loading geraniol (Ger) and icaridin (Ica) in three cell lines: NIH/3 T3, HaCaT, and SIRC...
December 1, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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