Ana Karolina de Souza Andrade, Mariana Nobre Farias de Franca, Jileno Ferreira Santos, Nathália Araújo Macêdo, Waldecy de Lucca Junior, Ricardo Scher, Socrates Cabral de Holanda Cavalcanti, Cristiane Bani Corrêa
Gliomas are among the most common primary malignant brain tumors. Despite advances in cancer treatment, survival is very low, so the discovery of new therapeutic agents is essential. In this context, indole is an important source for the development of new bioactive molecules. A pharmacological screening of ten indole derivatives was carried out to evaluate the cytotoxic capacity against three tumor cell lines. After pharmacological screening, three compounds were selected, based on their high capacity to reduce cell proliferation, and their IC50 values were determined...
January 30, 2024: Toxicology in Vitro: An International Journal Published in Association with BIBRA