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Oncology (Williston Park, NY)

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https://www.readbyqxmd.com/read/28205194/novel-and-expanded-oncology-drug-approvals-of-2016-part-2-new-options-in-the-management-of-hematologic-malignancies
#1
REVIEW
Todd C Knepper, James Saller, Christine M Walko
The recent past has brought pharmacotherapeutic advances that benefit patients with hematologic malignancies. In 2016, two novel hematology drugs were approved and four previously approved hematology drugs were granted expanded use for the treatment of appropriate patient populations by the US Food and Drug Administration. These new approvals and indications represent significant steps forward in patient management: they include the first-in-class B-cell lymphoma 2 inhibitor, venetoclax, the newest targeted therapy available for the treatment of hematologic malignancies; and nivolumab, the first immune checkpoint inhibitor to be approved for treatment of a hematologic malignancy...
February 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28205193/new-therapeutic-strategies-for-triple-negative-breast-cancer
#2
REVIEW
Borbála Székely, Andrea L M Silber, Lajos Pusztai
Relatively few clinically important therapeutic advances have occurred in the treatment of triple-negative breast cancer (TNBC) since the introduction of taxanes as adjuvant therapy over 20 years ago. However, this is rapidly changing due to a variety of conceptually important clinical trials and emerging new options such as immune checkpoint inhibitors and antibody-drug conjugates. Evidence also increasingly supports that platinum drugs and inhibitors of poly (ADP-ribose) polymerase, or PARP, are particularly effective in the treatment of germline BRCA-mutant cancers, including TNBC...
February 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28205192/a-60-year-old-man-with-progressive-anemia-while-receiving-checkpoint-blockade-therapy-for-relapsed-myelofibrosis
#3
Aaron M Goodman, Megan Rust, Caitlin Costello, Edward D Ball
No abstract text is available yet for this article.
February 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28205191/novel-and-expanded-oncology-drug-approvals-of-2016-part-1-new-options-in-solid-tumor-management
#4
REVIEW
Todd C Knepper, James Saller, Christine M Walko
The nonradiologic medical management of solid tumors has evolved from the use of traditional cytotoxic agents to modern targeted therapies, monoclonal antibodies, and immunotherapies. Advances in the understanding of cancer biology and therapeutic strategies have resulted in increasing numbers of new drug applications and approvals. Consequently, practicing oncologists need to learn how the newly available agents function and what toxicities to watch for, as well as ways to optimize the use of both new drugs and previously approved drugs with new indications...
February 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28205190/accelerated-partial-breast-irradiation-for-breast-cancer-not-ready-for-routine-use
#5
Jacqueline R Kelly, Suzanne Evans
No abstract text is available yet for this article.
February 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28205189/accelerated-partial-breast-irradiation-for-breast-cancer-an-innovative-option-for-selected-early-stage-cancers
#6
Robert R Kuske
No abstract text is available yet for this article.
February 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28205188/understanding-the-links-between-lung-cancer-copd-and-emphysema-a-key-to-more-effective-treatment-and-screening
#7
REVIEW
Luis M Seijo, Javier J Zulueta
Lung cancer has been linked to the changes in lung function characteristic of chronic obstructive pulmonary disease (COPD) and to the changes in lung morphology seen in emphysema. It seems that a common thread of smoking-induced lung injury can be traced to all three diseases. However, the association is not as straightforward as it may seem; for example, even never-smokers with emphysema have an increased risk of lung cancer. Whether lung cancer, COPD, and emphysema are linked by common genes, mechanisms, causes, or a combination thereof, understanding the associations between them has become a priority for research regarding tobacco-related illnesses...
February 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28205187/barbara-mcaneny-on-how-the-repeal-of-the-aca-without-a-replacement-threatens-the-health-of-patients-and-the-success-of-community-practices
#8
Barbara L McAneny
No abstract text is available yet for this article.
February 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28090627/fdg-pet-for-early-response-assessment-in-lymphomas-part-2-diffuse-large-b-cell-lymphoma-use-of-quantitative-pet-evaluation
#9
REVIEW
Bruce D Cheson, Lale Kostakoglu
In Part 1, we reviewed the role of interim positron emission tomography (PET)/CT scans in Hodgkin lymphoma. In advanced Hodgkin lymphoma, interim PET is a useful prognostic tool that can be used to implement risk-adapted therapy with potential benefits for both patients who have negative interim scans and those whose scans are positive. Interim PET/CT has not shown as encouraging results in diffuse large B-cell lymphoma (DLBCL), with the exception of germinal center B-cell DLBCL. Thus, quantitative methods of interpreting interim PET scans have been pursued in an effort to improve their predictive value...
15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28090626/active-surveillance-of-prostate-cancer
#10
Peter L Choyke, Stacy Loeb
No abstract text is available yet for this article.
January 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28090625/insights-into-the-appropriate-use-of-new-antimyeloma-therapies
#11
Jonathan L Kaufman, Sagar Lonial
No abstract text is available yet for this article.
January 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28090624/current-strategies-for-the-immunotherapy-of-multiple-myeloma
#12
REVIEW
Tim Luetkens, Sara Yousef, Sabarinath Venniyil Radhakrishnan, Djordje Atanackovic
The introduction of cellular immunotherapies using genetically modified T cells has revolutionized the treatment of patients with B-cell lymphomas. However, despite the progress made in this field, similarly effective immunotherapeutic approaches have not yet been identified for patients with solid tumors or other hematologic malignancies such as multiple myeloma. Here we outline the most promising novel cellular immune strategies for patients with multiple myeloma. In addition, we highlight combinatorial approaches that, it is hoped, will further optimize cellular immunotherapies for myeloma and lead to deep and durable responses and, possibly, even cures...
January 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28090623/palb2-positive-breast-cancer-in-a-40-year-old-man
#13
Pritish Iyer, Jagar Jasem, Michelle A Springer, Catherine E Klein, Peter Kabos
No abstract text is available yet for this article.
15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28090622/fdg-pet-for-early-response-assessment-in-lymphomas-part-1-hodgkin-lymphoma
#14
REVIEW
Bruce D Cheson, Lale Kostakoglu
Interim positron emission tomography (PET)/CT has shown encouraging results when used as a prognostic tool early in the course of treatment of advanced Hodgkin lymphoma, allowing for a reduction in treatment for patients with favorable characteristics, while suggesting a benefit from changing therapy for those with a positive scan. For patients with limited disease, a negative scan allows for a decrease in treatment; however, the benefits for those patients whose scans are positive are less certain. Here we critically analyze the role of PET/CT in the early assessment of Hodgkin lymphoma...
January 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28090621/the-challenges-of-treating-cancer-patients-on-hemodialysis-or-with-chronic-kidney-disease
#15
Charbel C Khoury, David J R Steele
No abstract text is available yet for this article.
January 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28090620/early-engagement-in-physical-activity-and-exercise-is-key-in-managing-cancer-cachexia
#16
Jo Bayly, Andrew Wilcock, Irene J Higginson, Matthew Maddocks
No abstract text is available yet for this article.
15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28090619/the-evolving-approach-to-management-of-cancer-cachexia
#17
REVIEW
Rony Dev, Angelique Wong, David Hui, Eduardo Bruera
Weight loss is distressing to cancer patients and caregivers. Anorexia/cachexia syndrome is characterized by lipolysis and the loss of lean body mass, and is not reversible by increasing caloric intake. The pathophysiology of cancer cachexia is complex and includes symptoms that impact caloric intake, as well as chronic inflammation, hypermetabolism, and hormonal alterations. Cancer patients require routine screening for cachexia and, ideally, interventions should be initiated in the early stages of weight loss...
January 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28090618/alan-blum-on-why-physicians-need-to-be-more-active-and-creative-in-the-clinic-classroom-and-community-in-smoking-prevention-and-cessation
#18
Alan Blum
No abstract text is available yet for this article.
January 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27987203/acr-appropriateness-criteria%C3%A2-recurrent-hodgkin-lymphoma
#19
REVIEW
Karen M Winkfield, Ranjana H Advani, Leslie K Ballas, Bouthaina S Dabaja, Sughosh Dhakal, Christopher R Flowers, Chul Soo Ha, Bradford S Hoppe, David B Mansur, Nancy P Mendenhall, Monika L Metzger, John P Plastaras, Kenneth B Roberts, Ronald Shapiro, Sonali M Smith, Stephanie A Terezakis, Anas Younes, Louis S Constine
This topic addresses the management of recurrent Hodgkin lymphoma. While autologous stem cell transplantation may be appropriate for select cases of recurrent disease following comprehensive combined-modality therapy, other options exist for patients treated with lower-dose therapy for early-stage disease. Additionally, innovative targeted therapies provide newer salvage options to consider. The American College of Radiology Appropriateness Criteria® are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel...
December 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27987201/treatment-of-acute-lymphoblastic-leukemia-in-adults-applying-lessons-learned-in-children
#20
REVIEW
Ibrahim T Aldoss, Guido Marcucci, Vinod Pullarkat
Although pediatric acute lymphoblastic leukemia (ALL) has cure rates of over 90%, adult ALL remains a challenging disease to treat, with cure rates roughly half those seen in children. The inferior outcomes in adults can be attributed mainly to adverse genetic features, as well as the inability-particularly of older adults-to tolerate chemotherapy. Modest improvements have been seen in outcomes for adolescents and young adults; these can largely be attributed to the use of pediatric-type combination chemotherapy regimens in patients aged 50 years or younger...
December 15, 2016: Oncology (Williston Park, NY)
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