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Oncology (Williston Park, NY)

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https://www.readbyqxmd.com/read/30153323/peripheral-t-cell-lymphomas-incorporating-new-developments-in-diagnostics-prognostication-and-treatment-into-clinical-practice-part-2-enktl-eatl-indolent-t-cell-ldp-of-the-gi-tract-atll-and-hepatosplenic-t-cell-lymphoma
#1
REVIEW
Natalia Pin Chuen Zing, Thais Fischer, Jasmine Zain, Massimo Federico, Steven T Rosen
The World Health Organization classification for peripheral T-cell lymphomas (PTCLs) continues to evolve based on genetic and clinical distinctions of each entity. In Part 1, an overview was provided of PTCL not otherwise specified, follicular T-cell lymphoma, angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma (ALCL), and breast implant-associated ALCL. In Part 2, this review is extended to extranodal natural killer (NK)/T-cell lymphoma, enteropathy-associated T-cell lymphoma, indolent T-cell lymphoproliferative disorder of the gastrointestinal tract, adult T-cell leukemia/lymphoma, and hepatosplenic T-cell lymphoma...
August 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/30153322/carboplatin-paclitaxel-induction-in-ovarian-cancer-the-finer-points
#2
Leslie R Boyd, Franco M Muggia
The carboplatin/paclitaxel doublet remains the chemotherapy backbone for the initial treatment of ovarian cancer. This two-drug regimen, with carboplatin dosed using the Calvert formula, yielded convincing noninferior outcomes when compared with the prior, more toxic, regimen of cisplatin/paclitaxel. Carboplatin's dose-limiting toxicity is thrombocytopenia; however, when this drug is properly dosed and combined with paclitaxel, the doublet's cycle 1 dose in chemotherapy-naive women is generally safe. Carboplatin (unlike cisplatin) contributes minimally to the cumulative sensory neuropathy of paclitaxel, thus ensuring noticeable reversibility of neuropathy symptoms following completion of 6 cycles and only occasionally requiring cessation or substitution of the taxane...
August 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/30153321/obese-breast-cancer-patients-and-survivors-management-considerations
#3
Jennifer Y Sheng, Dipali Sharma, Gerald Jerome, Cesar Augusto Santa-Maria
Excess body weight is a significant risk factor for many cancers, especially breast cancer. Patients with breast cancer or those with a history of the disease who are overweight or obese have an increased risk of therapy-related morbidity, recurrence, and breast cancer-related mortality. Obesity may also affect quality-of-life factors for survivors, including sexual dysfunction, neuropathy, cardiotoxicity, chronic fatigue, and lymphedema. Most cancer guidelines recommend that breast cancer survivors who are overweight or obese lose weight and that those with a normal body mass index (BMI) maintain a stable body weight...
August 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/30153320/counterpoint-can-chemotherapy-be-eliminated-in-the-treatment-of-follicular-lymphoma
#4
Paul M Barr
No abstract text is available yet for this article.
August 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/30153319/point-can-chemotherapy-be-eliminated-in-the-treatment-of-follicular-lymphoma
#5
Loretta J Nastoupil
No abstract text is available yet for this article.
August 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/30153318/eileen-parkes-on-why-cancer-researchers-are-excited-about-sting-agonists
#6
Eileen Parkes
No abstract text is available yet for this article.
August 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/30153317/multidisciplinary-approaches-to-chest-wall-recurrences-of-breast-cancer
#7
REVIEW
Cletus Arciero, Peter Thompson, Jane Lowe Meisel, Caitlin E Taylor, Mylin A Torres, William C Wood
The management of postmastectomy chest wall recurrences of breast cancer has long challenged clinicians. A tissue diagnosis combined with proper imaging and staging of patients to ensure the disease is localized are the first steps in management. Multimodal therapy offers patients the best chances of cure. In properly selected patients, complete surgical resection to negative margins, including full-thickness chest wall resection when required, followed by reconstruction that is well planned, can provide local control with very low surgical mortality and acceptable morbidity...
August 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/30153316/navigating-cancer-pain-management-in-the-midst-of-the-opioid-epidemic
#8
REVIEW
Judith A Paice
Cancer pain remains prevalent throughout the course of the disease, and it can be challenging to manage adequately. The challenge is compounded by the current opioid misuse epidemic. Substance use disorders (SUDs), including opioid use disorder, are common in the general population and may be seen with greater frequency in oncology settings. Risk factors contributing to the development of cancer, such as smoking or excessive drinking of alcohol, may place some patients at increased risk for SUDs. Additionally, cancer patients have a higher rate of psychological distress than the general population; psychological distress is an important risk factor for SUDs...
August 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/30080923/peripheral-t-cell-lymphomas-incorporating-new-developments-in-diagnostics-prognostication-and-treatment-into-clinical-practice-part-1-ptcl-nos-ftcl-aitl-alcl
#9
REVIEW
Natalia Pin Chuen Zing, Thais Fischer, Jasmine Zain, Massimo Federico, Steven T Rosen
Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of diseases, with low incidence and unique epidemiology and pathobiology; they are usually clinically aggressive, with poor outcomes. There have been significant advances in our understanding of the molecular and signaling alterations seen in these malignancies. These observations have led to novel therapeutic strategies that have had a meaningful impact on outcomes. This two-part series highlights the most important aspects of PTCLs and describes current treatment options and investigative opportunities...
July 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/30080922/harnessing-the-immunomodulatory-effects-of-radiation-therapy
#10
REVIEW
Allison M Campbell, Roy H Decker
In this article, we discuss the immunogenicity of radiation-induced cell death and describe the innate immune signaling pathways that precede adaptive antitumoral immunity. The innate and adaptive immune systems work in concert to generate systemic immune responses. In the setting of cancer, DNA damage caused by radiotherapy activates the innate immune system while tumor cell death liberates antigen that serves as a target for adaptive immunity. The immunomodulatory effects of radiation have been investigated in preclinical models; here we summarize the available data, with particular attention to the effects of radiotherapy timing, location, dose, and fractionation strategy on the antitumoral immune response...
July 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/30080921/post-prostatectomy-radiation-therapy-patient-selection-timing-imaging-and-therapy-intensification
#11
Tyler P Robin, Paul D Maroni, Bennett B Chin, Francisco G La Rosa, Brandon Bernard, Thomas J Pugh
No abstract text is available yet for this article.
July 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/30080920/acute-kidney-injury-in-patients-with-cancer
#12
Mark A Perazella, Mitchell H Rosner
Acute kidney injury (AKI) is a common complication in cancer patients and occurs in up to 30% of patients during their disease course. Multiple myeloma, leukemia/lymphoma, renal cell carcinoma, and hematopoietic stem cell transplantation are commonly associated with the development of AKI. Drugs used to treat various malignancies are also a common and notable cause of AKI in this population. Nephrology consultation is important to ensure proper and rapid diagnosis, as well as appropriate therapy and follow-up...
July 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/30080919/using-parp-inhibitors-in-advanced-ovarian-cancer
#13
Roisin E O'Cearbhaill
Poly(ADP-ribose) polymerase (PARP) proteins are used by cells in several DNA repair processes. PARP inhibition can result in preferential death of cancer cells when another mechanism for repairing DNA is defective. Two PARP inhibitors, olaparib and rucaparib, have been approved by the US Food and Drug Administration (FDA) for the treatment of recurrent, BRCA-associated ovarian cancer. More recently, these two and a third PARP inhibitor, niraparib, were approved by the FDA as maintenance therapy following platinum-based chemotherapy for recurrent ovarian cancer...
July 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/30080918/sharing-serious-news-with-cancer-patients-strategies-that-can-help
#14
Patricia A Parker, Smita C Banerjee
Sharing serious news is a key communication task that occurs frequently throughout the trajectory of caring for a cancer patient. When sharing serious news, it is important to consider many factors, including those related to patient diversity, such as cultural and family background; language barriers; socioeconomic factors; and health literacy. Importantly, the way in which serious news is discussed significantly affects many outcomes and aspects of patient care. Sharing serious news is not an innate skill but can be effectively taught and learned...
July 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/30080917/narjust-duma-on-how-gender-affects-the-tolerability-of-immunotherapy
#15
Narjust Duma
No abstract text is available yet for this article.
July 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29940065/the-use-of-surgery-and-radiotherapy-as-treatment-of-regional-nodes-in-breast-cancer-patients
#16
REVIEW
Melissa P Mitchell, Priyanka Sharma
Ipsilateral regional nodal status is an important independent prognostic factor for patients with breast cancer. Several decisions regarding local therapy are necessary for patients found to have pathologically involved lymph node(s). This article reviews the role of completion dissection and/or radiation therapy in patients found to have positive sentinel lymph node(s), taking into consideration use of mastectomy vs lumpectomy, tumor characteristics, tumor biology, plans for systemic therapy, and patient preferences...
June 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29940064/immunotherapy-for-prostate-cancer-where-do-we-go-from-here-part-2-checkpoint-inhibitors-immunotherapy-combinations-tumor-microenvironment-modulation-and-cellular-therapies
#17
REVIEW
Amar Patel, Lawrence Fong
Therapeutic approaches that harness the power of the immune system to eliminate cancer cells have produced a paradigm shift in the management of a variety of malignancies. Prostate cancer has been a particularly active area of investigation in cancer immunotherapy, with significant laboratory and clinical evidence suggesting that this disease can be a viable target for cytotoxic immune cells. In the first article of this series, we discussed the diverse vaccination approaches that have been employed to prime native antigen-specific responses against prostate cancer, highlighting successes such as sipuleucel-T, as well as the significant challenges that remain...
June 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29940063/understanding-the-benefits-of-acupuncture-treatment-for-cancer-pain-management
#18
REVIEW
Gary Deng, Ting Bao, Jun J Mao
This article summarizes the current evidence regarding the use of acupuncture for pain management in cancer patients. It includes a description of how acupuncture is thought to work and what the intervention entails, data on acupuncture for managing pain caused by cancer or by cancer treatment (radiation, chemotherapy, endocrine therapy), how acupuncture is practiced in the US medical system, discussion of safety issues, and practical tips on how to integrate acupuncture into cancer care.
June 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29940062/how-to-decide-which-dlbcl-patients-should-receive-cns-prophylaxis
#19
REVIEW
Kevin H Hall, Elyse Hall Panjic, Kelly Valla, Christopher R Flowers, Jonathon B Cohen
Secondary central nervous system (CNS) relapse in aggressive non-Hodgkin lymphoma (NHL) is a dismal diagnosis with poor outcomes. While prophylaxis against secondary CNS disease is recommended in patients with highly aggressive NHLs, such as Burkitt lymphoma, patients with diffuse large B-cell lymphoma (DLBCL) present a challenging clinical dilemma due to an inherently lower risk of CNS relapse. Current guidelines suggest that prophylaxis may benefit DLBCL patients at high risk for CNS relapse; however, it has been difficult to define which patients are truly at high risk...
June 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29940061/a-35-year-old-woman-with-a-change-in-her2-expression-following-neoadjuvant-chemotherapy-for-invasive-breast-cancer
#20
Ericson Stoen, Peter Kabos, Kelly C Borden, Regina J Brown, Virginia F Borges, Jennifer R Diamond
No abstract text is available yet for this article.
June 2018: Oncology (Williston Park, NY)
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