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Oncology (Williston Park, NY)

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https://www.readbyqxmd.com/read/27987203/acr-appropriateness-criteria%C3%A2-recurrent-hodgkin-lymphoma
#1
REVIEW
Karen M Winkfield, Ranjana H Advani, Leslie K Ballas, Bouthaina S Dabaja, Sughosh Dhakal, Christopher R Flowers, Chul Soo Ha, Bradford S Hoppe, David B Mansur, Nancy P Mendenhall, Monika L Metzger, John P Plastaras, Kenneth B Roberts, Ronald Shapiro, Sonali M Smith, Stephanie A Terezakis, Anas Younes, Louis S Constine
This topic addresses the management of recurrent Hodgkin lymphoma. While autologous stem cell transplantation may be appropriate for select cases of recurrent disease following comprehensive combined-modality therapy, other options exist for patients treated with lower-dose therapy for early-stage disease. Additionally, innovative targeted therapies provide newer salvage options to consider. The American College of Radiology Appropriateness Criteria® are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel...
December 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27987201/treatment-of-acute-lymphoblastic-leukemia-in-adults-applying-lessons-learned-in-children
#2
REVIEW
Ibrahim T Aldoss, Guido Marcucci, Vinod Pullarkat
Although pediatric acute lymphoblastic leukemia (ALL) has cure rates of over 90%, adult ALL remains a challenging disease to treat, with cure rates roughly half those seen in children. The inferior outcomes in adults can be attributed mainly to adverse genetic features, as well as the inability-particularly of older adults-to tolerate chemotherapy. Modest improvements have been seen in outcomes for adolescents and young adults; these can largely be attributed to the use of pediatric-type combination chemotherapy regimens in patients aged 50 years or younger...
December 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27987200/metastatic-papillary-adenocarcinoma-in-a-22-year-old-is-her-history-of-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome-causative-or-incidental
#3
Regina J Brown, Joshua H Petit, Lars Widdel, Patricia S Huguelet, Colin Weekes
No abstract text is available yet for this article.
December 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27987199/breast-cancer-after-hodgkin-lymphoma-the-price-of-success
#4
Veronica Manzo, Frederick Dirbas, Melinda L Telli
No abstract text is available yet for this article.
December 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27987198/breast-cancer-following-radiation-for-hodgkin-lymphoma-clinical-scenarios-and-risk-reducing-strategies
#5
REVIEW
Linda Overholser, Elena Shagisultanova, Rachel A Rabinovitch, Nicole Kounalakis, Jennifer Diamond, Christina A Finlayson, Christine M Fisher, Peter Kabos, Anthony D Elias, Virginia F Borges, Jose Mayordomo
Since most patients with Hodgkin lymphoma survive their disease, long-term issues such as development of second primary malignancies arise, especially in patients treated with multimodal therapy including radiation therapy plus chemotherapy. The risk of breast cancer is significantly elevated in women exposed to high-dose ionizing radiation to the chest before age 40. The case of a 48-year-old patient with a lump in her right breast is presented as a clinical scenario in this article. We review available strategies for screening and risk reduction through chemoprevention or risk-reducing surgery, as well as challenges for management of breast cancer in patients with prior exposure to radiation for Hodgkin lymphoma...
December 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27987197/counterpoint-the-role-of-stem-cell-transplantation-in-mantle-cell-lymphoma
#6
Leo I Gordon
No abstract text is available yet for this article.
December 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27987196/point-the-role-of-stem-cell-transplantation-in-mantle-cell-lymphoma
#7
Andre Goy
No abstract text is available yet for this article.
December 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27987195/new-does-not-always-mean-better-isolated-limb-perfusion-still-has-a-role-in-the-management-of-in-transit-melanoma-metastases
#8
Igor Puzanov, Joseph Skitzki
No abstract text is available yet for this article.
December 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27987194/isolated-limb-perfusion-for-stage-iii-melanoma-does-it-still-have-a-role-in-the-present-era-of-effective-systemic-therapy
#9
REVIEW
Dirk J Grünhagen, Cornelis Verhoef
The management of advanced-stage melanoma has changed dramatically with the introduction of systemic targeted therapy and immunotherapy. Patients with stage IV melanoma currently benefit from agents that are extremely effective, especially when compared with classic chemotherapeutic agents. The field is still evolving, and these newer agents are now used in patients with stage III disease, in the setting of adjuvant trials after resection of the disease bulk. Patients with bulky and numerous in-transit metastases form a very distinct subset of melanoma patients...
December 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27987193/amitkumar-mehta-on-the-immunomodulating-effects-of-targeted-therapy-for-multiple-myeloma
#10
Amitkumar Mehta
No abstract text is available yet for this article.
December 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27933601/breast-cancer-outlook-for-2017-keeping-the-accelerator-to-the-floor
#11
Vijayakrishna K Gadi, Julie R Gralow
No abstract text is available yet for this article.
December 1, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854105/chemotherapy-induced-peripheral-neuropathy-a-challenge-for-clinicians
#12
Salahadin Abdi, Patrick M Dougherty
No abstract text is available yet for this article.
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854104/new-practical-approaches-to-chemotherapy-induced-neuropathic-pain-prevention-assessment-and-treatment
#13
REVIEW
Neil Majithia, Charles L Loprinzi, Thomas J Smith
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most disabling and demoralizing problems that arise for cancer survivors. When investigating symptoms of numbness, tingling, or pain in the extremities, it is critical to determine whether the problem is neuropathic, somatic, or mixed. If the diagnosis is CIPN, it is important to weigh the potential benefits and harms of possible treatment options, and to devise an evidence-based multimodality treatment program. Such programs may include mixtures of opioid and nonopioid adjunctive medications, based on evidence from CIPN trials, and also extrapolation from trials in patients with other neuropathic pain syndromes-although such extrapolating must be done with caution, since other syndromes sometimes respond to agents that CIPN does not respond to...
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854103/using-targeted-inhibitors-in-the-management-of-chronic-lymphocytic-leukemia-are-we-there-yet
#14
Jennifer R Brown
No abstract text is available yet for this article.
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854102/the-next-generation-of-targeted-molecules-for-the-treatment-of-chronic-lymphocytic-leukemia
#15
REVIEW
Deepa Jeyakumar, Susan O'Brien
With the recent approval of several new targeted therapies for chronic lymphocytic leukemia (CLL), there are now multiple options for its treatment. Inhibitors of Bruton tyrosine kinase (with ibrutinib being the first-in-class US Food and Drug Administration-approved agent) and phosphoinositide 3-kinase (with idelalisib as the first-in-class approved agent) are promising because they are generally well tolerated and highly effective against this malignancy. These agents may be particularly important in the treatment of older patients who are less able to tolerate the myelosuppression (and subsequent infections) associated with chemoimmunotherapy...
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854101/middle-aged-man-with-acute-thrombocytopenia-subsequent-to-fluorouracil-and-oxaliplatin-chemotherapy-for-colorectal-cancer
#16
Henning Schade, Lindsey Davis, Peter Kabos
No abstract text is available yet for this article.
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854100/minimally-invasive-lung-resection-when-is-a-vats-not-a-vats
#17
Daryl P Pearlstein
No abstract text is available yet for this article.
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854099/minimally-invasive-surgery-for-early-stage-lung-cancer-from-innovation-to-standard-of-care
#18
REVIEW
Abby White, Scott J Swanson
The era of minimally invasive surgery for lung cancer follows decades of research; the collection and interpretation of countless qualitative and quantitative data points; and tireless efforts by a few pioneering thoracic surgeons who believed they could deliver a safe and oncologically sound operation with less tissue trauma, an improved physiologic profile, and fewer complications than traditional open surgery. This review highlights those efforts and the role of minimally invasive surgery for early-stage lung cancer in light of evolving technology, the emerging understanding of the biology of early-stage lung cancer, and lung cancer screening...
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854098/outwitting-the-blood-brain-barrier
#19
Edward Neuwelt, Prakash Ambady, Leslie Muldoon, Heather McConnell, Nancy Doolittle
No abstract text is available yet for this article.
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854097/optimizing-the-delivery-of-antineoplastic-therapies-to-the-central-nervous-system
#20
REVIEW
Jarushka Naidoo, Hardik Panday, Sadhana Jackson, Stuart A Grossman
Despite significant advances in the treatment of systemic cancers, progress in the treatment of primary brain tumors has been quite modest. In addition, an increasing proportion of patients with systemic cancers are presenting with brain-only metastases. These observations highlight the critical role that the blood-brain barrier plays in preventing antineoplastic therapies from reaching the central nervous system in therapeutic concentrations. This review describes the anatomy of the blood-brain barrier and currently available methods to quantify the entry of therapeutic compounds into the brain...
November 15, 2016: Oncology (Williston Park, NY)
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