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Oncology (Williston Park, NY)

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https://www.readbyqxmd.com/read/29083471/counterpoint-early-salvage-vs-adjuvant-radiotherapy-for-high-risk-prostate-cancer
#1
Wayland J Wu, Louis Potters
No abstract text is available yet for this article.
October 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29083470/point-early-salvage-vs-adjuvant-radiotherapy-for-high-risk-prostate-cancer
#2
Rahul Tendulkar
No abstract text is available yet for this article.
October 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29083469/nonoperative-management-of-rectal-cancer-a-modern-perspective
#3
REVIEW
Yushen Qian, Alexander L Chin, Diego A S Toesca, Albert C Koong, Daniel T Chang
Nonoperative management of rectal cancer is an emerging treatment approach that aims to enable carefully selected patients to avoid the morbidity of radical surgical resection, while benefiting from the same excellent rates of tumor control achieved with radical surgery-based combined-modality therapy. The success of nonoperative management in this setting is based on the accurate assessment of tumor eradication after chemoradiotherapy, without pathologic verification. Therefore, clinical evidence of complete response-based on physical examination, endoscopic procedures, and imaging-must be utilized as a marker to predict for pathologic complete response and thus help select the patients who are most appropriate for nonoperative management...
October 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29083468/pancreatic-neuroendocrine-tumors-state-of-the-art-diagnosis-and-management
#4
REVIEW
Aaron Lewis, Daneng Li, John Williams, Gagandeep Singh
The incidence of pancreatic neuroendocrine tumors (PNETs) has significantly increased in recent years, although this may reflect better detection and improved diagnosis, in addition to a true increase in incidence. The majority of PNETs are nonfunctional; up to half of nonmetastatic PNETs will present incidentally, and 85% will develop metastases over their lifetime. Treatment of PNETs is largely dictated by their heterogeneous nature and usually indolent behavior. Surgery is a mainstay of treatment, both in early PNETs and in metastatic disease...
October 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29083467/reducing-racial-disparities-in-breast-cancer-care-the-role-of-big-data
#5
REVIEW
Katherine E Reeder-Hayes, Melissa A Troester, Anne-Marie Meyer
Advances in a wide array of scientific technologies have brought data of unprecedented volume and complexity into the oncology research space. These novel big data resources are applied across a variety of contexts-from health services research using data from insurance claims, cancer registries, and electronic health records, to deeper and broader genomic characterizations of disease. Several forms of big data show promise for improving our understanding of racial disparities in breast cancer, and for powering more intelligent and far-reaching interventions to close the racial gap in breast cancer survival...
October 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29083466/pneumonitis-from-anti-pd-1-pd-l1-therapy
#6
Aanika Balaji, Franco Verde, Karthik Suresh, Jarushka Naidoo
Pneumonitis is defined as a focal or diffuse inflammation of the lung parenchyma, and is a known, potentially fatal toxicity of anti-programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) immune checkpoint inhibitors. Herein we discuss two patients who developed pneumonitis secondary to anti-PD-1/PD-L1 immune checkpoint inhibitor therapy and illustrate a stepwise approach to the diagnostic evaluation and management of anti-PD-1/PD-L1-related pneumonitis. In the majority of patients who develop this toxicity, pneumonitis appears to clinically resolve with corticosteroid therapy alone; however, a subset of patients require additional immunosuppressive medications...
October 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29083465/management-of-breast-cancer-therapy-related-sexual-dysfunction
#7
Caitlin E Taylor, Jane Lowe Meisel
Sexual dysfunction is a prevalent concern among breast cancer survivors, and is often multifactorial in nature. Causes can be both physiologic and psychological; chemotherapy, endocrine therapy, and disfigurement from breast cancer surgery can all play a role. Sexual dysfunction can have a profound impact on quality of life and relationships and can also impact adherence to endocrine therapy. However, it can be a difficult topic for both patients and providers to bring up, and as a result, it is often inadequately addressed...
October 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29083464/initiating-exercise-interventions-to-promote-wellness-in-cancer-patients-and-survivors
#8
REVIEW
Anna L Schwartz, Hendrik Dirk de Heer, Jennifer W Bea
Exercise is associated with significant reductions in the recurrence and mortality rates of several common cancers. Cancer survivors who exercise can potentially benefit from reduced levels of fatigue, and improved quality of life, physical function, and body composition (ie, healthier ratios of lean body mass to fat mass). The amount of activity required to achieve protective effects is moderate (eg, walking 30 minutes per day at 2.5 miles per hour). However, many healthcare providers report a lack of awareness of the appropriate exercise recommendations across the phases of cancer survivorship, considerations regarding the timing of exercise interventions, and the ability to refer patients to exercise programs specifically aimed at cancer survivors...
October 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29083463/blase-polite-on-how-disparities-research-must-move-into-an-era-of-action
#9
Blase N Polite
No abstract text is available yet for this article.
October 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29083462/integrative-oncology-for-practicing-clinicians-sio-and-oncology-establish-new-partnership
#10
Jun J Mao
No abstract text is available yet for this article.
October 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29071696/diagnosing-and-managing-delirium-in-cancer-patients
#11
Andrew Edelstein, Yesne Alici
Delirium is frequently encountered when caring for cancer patients, from initial diagnosis to the advanced stages of the disease; however, it is often missed. Oncologists need to be familiar with the various defining features of the condition, and should be able to identify common underlying causes. We present a systematic approach to the workup, as well as pharmacologic and nonpharmacologic approaches to management. We discuss the common practice of treatment with neuroleptics, as well as recent controversy surrounding their use...
September 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29071695/newer-strategies-for-the-management-of-low-grade-gliomas
#12
Karan Dixit, Jeffrey Raizer
Low-grade gliomas are infiltrative primary brain tumors that most commonly occur in young adults. They are relatively slow growing compared with high-grade gliomas. The World Health Organization classification system was updated in 2016 to define low-grade gliomas using molecular markers in addition to histology. IDH mutation is an independent marker associated with better outcomes. Management is individualized based on tumor histology, molecular characterization, and patient risk factors. Given the longer course and natural history of low-grade gliomas, the goals of treatment should be to prolong overall survival and minimize neurocognitive decline...
September 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29071694/large-scrotal-mass-with-multifocal-intra-abdominal-retroperitoneal-and-pelvic-metastases
#13
Christine Ibilibor, Allan Haynes, Pranav Sharma
No abstract text is available yet for this article.
September 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29071693/changing-treatment-paradigms-for-brain-metastases-from-melanoma-part-2-when-and-how-to-use-the-new-systemic-agents
#14
REVIEW
Vyshak Alva Venur, Pauline Funchain, Rupesh Kotecha, Samuel T Chao, Manmeet S Ahluwalia
Until recently, therapeutic strategies for melanoma brain metastases focused on local treatments: surgery, whole-brain radiation therapy, and stereotactic radiosurgery. Historically, systemic therapy had limited utility. Immunotherapeutic drugs, such as anti-cytotoxic T-lymphocyte-associated antigen 4 and anti-programmed death 1 agents, and agents targeting the BRAF-MEK pathway have revolutionized the systemic treatment of melanoma brain metastases. Recent clinical trials of these agents have shown activity against melanoma brain metastases, and they are increasingly being used in clinical practice...
September 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29071692/david-sher-on-the-updated-astro-guidelines-for-oropharyngeal-cancer
#15
David J Sher
No abstract text is available yet for this article.
September 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28831777/counterpoint-should-radiation-therapy-after-surgery-for-ductal-carcinoma-in-situ-be-standard-practice
#16
William C Wood
No abstract text is available yet for this article.
August 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28812305/point-should-radiation-therapy-after-surgery-for-ductal-carcinoma-in-situ-be-standard-practice
#17
Camille Berriochoa, Carisa Bohnak, Nicole Chahine, Chirag Shah
No abstract text is available yet for this article.
August 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28812304/management-of-castration-resistant-taxane-resistant-prostate-cancer
#18
Tomasz M Beer
Metastatic castration-resistant prostate cancer that is progressing despite docetaxel chemotherapy is difficult to treat and often aggressive. If not previously used, modern androgen signaling inhibitors have established clinical activity in this setting. Cabazitaxel and radium-223 have also been shown to extend survival in appropriately selected patients. Carboplatin-containing chemotherapy regimens have not been studied in randomized trials with a survival endpoint, but they have demonstrated activity in phase II trials and are occasionally considered in the post-docetaxel setting...
August 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28812303/circulating-tumor-dna-as-a-liquid-biopsy-current-clinical-applications-and-future-directions
#19
REVIEW
Kimberly M Komatsubara, Adrian G Sacher
Tumor genomic sequencing has become part of routine oncology practice in many tumor types, in order to identify potentially targetable mutations and to personalize cancer care. Plasma genotyping via circulating tumor DNA analysis is a noninvasive and rapid alternative method of detecting and monitoring genomic alterations throughout the course of disease. Multiple assays have been developed to date, each with different test characteristics and degrees of clinical validation. Here we review the clinical data supporting these different plasma genotyping methodologies, and present a practical approach to the interpretation of the results of these tests...
August 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28812302/management-of-sleep-wake-disturbances-comorbid-with-cancer
#20
Ann M Berger, Ellyn E Matthews, Ashley M Kenkel
It is critical that clinicians and healthcare systems adopt routine screening and affordable interventions to reduce chronic insomnia and improve the quality of life in cancer patients and survivors. We provide expert clinical advice on how to manage sleep-wake disturbances that occur comorbidly with cancer. Our discussion focuses on the etiology, screening, and assessment of sleep-wake disturbances, and on both nonpharmacologic and pharmacologic interventions to manage sleep disturbances, insomnia, and sleep-related breathing disorders...
August 15, 2017: Oncology (Williston Park, NY)
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