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Oncology (Williston Park, NY)

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https://www.readbyqxmd.com/read/29684235/implications-of-mutation-profiling-in-myeloid-malignancies-part-1-myelodysplastic-syndromes-and-acute-myeloid-leukemia
#1
REVIEW
Douglas Tremblay, Kelsey Sokol, Sheena Bhalla, Raajit Rampal, John O Mascarenhas
The advent of high-throughput gene sequencing has revolutionized our understanding of the genetic mutations that drive myeloid malignancies. While these mutations are of interest pathobiologically, they are increasingly being recognized as clinically meaningful in providing diagnostic, prognostic, and therapeutic information to guide patient care. In this first part of our two-part review, we introduce mutation profiling as a relevant clinical tool for hematologists treating patients with myeloid malignancies...
April 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29684234/systemic-treatment-options-for-brain-metastases-from-non-small-cell-lung-cancer
#2
REVIEW
Ajaz Bulbul, Patrick M Forde, Ayesha Murtuza, Brian Woodward, Hannah Yang, Ingmar Bastian, Parissa K Ferguson, Fernando Lopez-Diaz, David S Ettinger, Hatim Husain
Brain metastases are common in patients with non-small-cell lung cancer (NSCLC). Because of associated poor prognosis and limited specific treatment options, there is a real need for the development of medical therapies and strategies for affected patients. Novel compounds for epidermal growth factor receptor-dependent and anaplastic lymphoma kinase-dependent lung cancer have demonstrated blood-brain barrier permeability and have led to important improvements in central nervous system outcomes. Studies of targeted therapies for oncogene-driven tumors and of immunotherapies in patients with brain metastases have shown promise and, allied with novel radiation techniques, are driving a rapid evolution in treatment and prognosis for NSCLC brain metastases...
April 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29684233/secondary-prevention-strategies-for-nonmelanoma-skin-cancer
#3
REVIEW
Adriana T Lopez, Richard D Carvajal, Larisa Geskin
Skin cancer is the most commonly diagnosed cancer in the United States and has become a major public health problem that continues to grow. Despite numerous initiatives and increased public awareness of the dangers of skin cancer, the incidence of skin cancer continues to rise worldwide. This highlights the need for a critical review of existing skin cancer prevention strategies as a means to determine where targeted efforts may improve patient outcomes. In this article, we review the published literature and evaluate secondary prevention strategies for nonmelanoma skin cancer...
April 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29684232/immune-checkpoint-inhibitor-therapy-in-patients-with-autoimmune-disease
#4
Douglas B Johnson, Kathryn E Beckermann, Daniel Y Wang
Immune checkpoint inhibitors have demonstrated efficacy across many cancer types in numerous clinical trials. However, because patients with preexisting autoimmune disease were excluded from these seminal trials, there are serious gaps in knowledge regarding the efficacy-and in particular the safety-of these transformative agents in patients with autoimmune disease. The safety of immune checkpoint inhibitors in this population has been an important concern, since these agents unleash immune activation, a potentially dangerous situation for patients with already heightened and aberrant immune function...
April 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29684231/bilateral-multifocal-renal-masses-in-a-35-year-old-man-with-a-history-of-tuberous-sclerosis-complex
#5
Pranav Sharma, Allan Haynes
No abstract text is available yet for this article.
April 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29684230/effective-palliative-care-what-is-involved
#6
REVIEW
Mehak Swami, Amy Allen Case
It is important for oncologists who provide comprehensive cancer care to be familiar with the principles of primary palliative care and interdisciplinary team-based approaches to palliative care. Palliative care is a medical subspecialty that provides specialized care to individuals with serious illnesses, with a primary focus on providing symptom relief, pain management, and relief from psychosocial distress, regardless of diagnosis or prognosis. Ideally, palliative care is provided by a team of physicians, nurses, social workers, psychologists, and chaplains...
April 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29684229/counterpoint-lhrh-agonists-vs-ovarian-ablation-for-suppression-of-ovarian-function-in-premenopausal-breast-cancer-patients
#7
Philip D Poorvu, Ann H Partridge
No abstract text is available yet for this article.
April 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29684228/point-lhrh-agonists-vs-ovarian-ablation-for-suppression-of-ovarian-function-in-premenopausal-breast-cancer-patients
#8
Gini F Fleming, Padma Rajagopal
No abstract text is available yet for this article.
April 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29684227/razelle-kurzrock-and-shumei-kato-on-immunotherapy-and-hyperprogression-of-disease
#9
Razelle Kurzrock, Shumei Kato
No abstract text is available yet for this article.
April 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29548069/response-and-development-of-immune-related-adverse-events-in-an-83-year-old-man-with-metastatic-urothelial-cancer
#10
Karishma K Mehra, Daniel P Petrylak
No abstract text is available yet for this article.
March 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29548068/managing-nausea-and-vomiting-in-patients-with-cancer-what-works
#11
Rudolph M Navari
The approach to the treatment of nausea and vomiting in a cancer patient should begin with a complete assessment, including the frequency, duration, and intensity of the nausea/vomiting; associated activities; and whether anorexia or cachexia is present. It is important to determine whether the nausea and vomiting is related to treatment (chemotherapy, radiation) or is independent of cancer treatment. Nausea/vomiting unrelated to chemotherapy and/or radiation may have an etiology for which there is a specific and potentially successful intervention...
March 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29548067/my-signature-scent
#12
Eileen Parkes
No abstract text is available yet for this article.
March 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29548066/immunotherapy-plus-stereotactic-radiosurgery-building-on-the-promise-of-precision-medicine-for-cns-malignancies-part-2-existing-experience-and-considerations-for-future-trials
#13
REVIEW
Isabella Zhang, Silvia C Formenti, Jonathan P S Knisely
The brain has long been considered an immunologically privileged site, and the role of immunotherapy in treating intracranial disease has only recently been revived-with preclinical evidence showing that the systemic immune system responds to immunotherapy for intracranial disease, and with clinical evidence demonstrating improved locoregional control and survival compared with historical outcomes when immune-directed therapies are combined with radiation. Pharmaceutical industry-supported multi-institutional drug efficacy studies routinely exclude patients with brain metastases, so current evidence for treatment of brain metastases using stereotactic radiosurgery combined with immunotherapy comes from single-institution studies...
March 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29548065/immunotherapy-for-prostate-cancer-where-do-we-go-from-here-part-1-prostate-cancer-vaccines
#14
REVIEW
Amar Patel, Lawrence Fong
Immunotherapies have emerged as a revolutionary modality for cancer treatment, and a variety of immune-based approaches are currently being investigated in the field of prostate cancer. Despite the 2010 approval of sipuleucel-T, subsequent progress in prostate cancer immunotherapy development has been limited by disappointing results with novel vaccination approaches and by prostate cancer's general resistance to immune checkpoint blockade. Nevertheless, there remains strong preclinical and clinical evidence to suggest that prostate cancer is a susceptible target for immune therapies...
March 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29548064/using-genomic-sequencing-to-improve-management-in-melanoma
#15
Pauline Funchain, Ahmad A Tarhini
Rapidly advancing genomic sequencing technologies are changing all areas of cancer, from diagnosis to surveillance, and prognostication to treatment. The role of genomic testing in melanoma is expanding, and multiple genomically based tests are available, including somatic tumor sequencing for actionable genetic alterations and tumor mutational burden, prognostic gene expression profiling from tumor tissue, and germline genetic testing from blood. The available testing options have varying levels of supporting data, from robust to preliminary...
March 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29492951/immunotherapy-plus-stereotactic-radiosurgery-building-on-the-promise-of-precision-medicine-for-cns-malignancies-part-1-principles-of-combined-treatment
#16
REVIEW
Isabella Zhang, Silvia C Formenti, Jonathan P S Knisely
The role of systemic therapy in the treatment of intracranial metastases has traditionally been limited by the blood-brain barrier, and radiation therapy-either with whole-brain treatment or stereotactic radiosurgery-has remained a primary treatment modality. Recent evidence has demonstrated that antigens released in the brain can inform the systemic immune system, and systemic antibodies can traverse into the brain. This has led to a renewed interest in investigating novel immunotherapy agents to treat both systemic and intracranial disease...
February 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29492950/wedding-rigorous-scientific-methodology-and-ancient-herbal-wisdom-to-benefit-cancer-patients-the-development-of-phy906
#17
Edward Chu
Our research group has extensively characterized the preclinical and clinical activities of PHY906, a traditional Chinese herbal medicine, as a modulator of irinotecan-based chemotherapy for the treatment of colorectal cancer. This article reviews the critical issues of quality control and standardization of PHY906 and highlights the importance of high-quality material for the conduct of preclinical and clinical studies. Studies to investigate the potential biological mechanisms of action using a systems biology approach play a pivotal role in providing the preclinical rationale to move forward with clinical studies...
February 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29492949/primary-central-nervous-system-lymphoma-part-2-modern-therapeutic-management-and-future-directions
#18
REVIEW
Rimas V Lukas, Vinai Gondi, Roger Stupp, Jeffrey J Raizer
Primary central nervous system (CNS) lymphoma, a rare CNS neoplasm associated with high mortality, is responsive to therapeutic interventions. In Part 1 of our two-part coverage of this entity, we provided an overview of the epidemiology of primary CNS lymphoma, followed by a discussion of the diagnostic and staging evaluation, and a review of current prognostication systems. In Part 2, we discuss the management of primary CNS lymphoma, focusing in particular on systemic therapies and radiation. With respect to systemic therapies, we provide details of a variety of regimens built around a backbone of high-dose methotrexate...
February 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29492948/counterpoint-is-there-still-a-role-for-intraperitoneal-platinum-therapy-in-ovarian-cancer
#19
Robert F Ozols
No abstract text is available yet for this article.
February 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29492947/point-is-there-still-a-role-for-intraperitoneal-platinum-therapy-in-ovarian-cancer
#20
Keiichi Fujiwara
No abstract text is available yet for this article.
February 15, 2018: Oncology (Williston Park, NY)
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