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Oncology (Williston Park, NY)

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https://www.readbyqxmd.com/read/27854105/chemotherapy-induced-peripheral-neuropathy-a-challenge-for-clinicians
#1
Salahadin Abdi, Patrick M Dougherty
No abstract text is available yet for this article.
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854104/new-practical-approaches-to-chemotherapy-induced-neuropathic-pain-prevention-assessment-and-treatment
#2
REVIEW
Neil Majithia, Charles L Loprinzi, Thomas J Smith
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most disabling and demoralizing problems that arise for cancer survivors. When investigating symptoms of numbness, tingling, or pain in the extremities, it is critical to determine whether the problem is neuropathic, somatic, or mixed. If the diagnosis is CIPN, it is important to weigh the potential benefits and harms of possible treatment options, and to devise an evidence-based multimodality treatment program. Such programs may include mixtures of opioid and nonopioid adjunctive medications, based on evidence from CIPN trials, and also extrapolation from trials in patients with other neuropathic pain syndromes-although such extrapolating must be done with caution, since other syndromes sometimes respond to agents that CIPN does not respond to...
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854103/using-targeted-inhibitors-in-the-management-of-chronic-lymphocytic-leukemia-are-we-there-yet
#3
Jennifer R Brown
No abstract text is available yet for this article.
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854102/the-next-generation-of-targeted-molecules-for-the-treatment-of-chronic-lymphocytic-leukemia
#4
REVIEW
Deepa Jeyakumar, Susan O'Brien
With the recent approval of several new targeted therapies for chronic lymphocytic leukemia (CLL), there are now multiple options for its treatment. Inhibitors of Bruton tyrosine kinase (with ibrutinib being the first-in-class US Food and Drug Administration-approved agent) and phosphoinositide 3-kinase (with idelalisib as the first-in-class approved agent) are promising because they are generally well tolerated and highly effective against this malignancy. These agents may be particularly important in the treatment of older patients who are less able to tolerate the myelosuppression (and subsequent infections) associated with chemoimmunotherapy...
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854101/middle-aged-man-with-acute-thrombocytopenia-subsequent-to-fluorouracil-and-oxaliplatin-chemotherapy-for-colorectal-cancer
#5
Henning Schade, Lindsey Davis, Peter Kabos
No abstract text is available yet for this article.
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854100/minimally-invasive-lung-resection-when-is-a-vats-not-a-vats
#6
Daryl P Pearlstein
No abstract text is available yet for this article.
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854099/minimally-invasive-surgery-for-early-stage-lung-cancer-from-innovation-to-standard-of-care
#7
REVIEW
Abby White, Scott J Swanson
The era of minimally invasive surgery for lung cancer follows decades of research; the collection and interpretation of countless qualitative and quantitative data points; and tireless efforts by a few pioneering thoracic surgeons who believed they could deliver a safe and oncologically sound operation with less tissue trauma, an improved physiologic profile, and fewer complications than traditional open surgery. This review highlights those efforts and the role of minimally invasive surgery for early-stage lung cancer in light of evolving technology, the emerging understanding of the biology of early-stage lung cancer, and lung cancer screening...
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854098/outwitting-the-blood-brain-barrier
#8
Edward Neuwelt, Prakash Ambady, Leslie Muldoon, Heather McConnell, Nancy Doolittle
No abstract text is available yet for this article.
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27854097/optimizing-the-delivery-of-antineoplastic-therapies-to-the-central-nervous-system
#9
REVIEW
Jarushka Naidoo, Hardik Panday, Sadhana Jackson, Stuart A Grossman
Despite significant advances in the treatment of systemic cancers, progress in the treatment of primary brain tumors has been quite modest. In addition, an increasing proportion of patients with systemic cancers are presenting with brain-only metastases. These observations highlight the critical role that the blood-brain barrier plays in preventing antineoplastic therapies from reaching the central nervous system in therapeutic concentrations. This review describes the anatomy of the blood-brain barrier and currently available methods to quantify the entry of therapeutic compounds into the brain...
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27848244/the-surgical-management-of-peritoneal-carcinomatosis-of-colorectal-origin
#10
Shanel B Bhagwandin, Ramy Fouad, Daniel M Labow
No abstract text is available yet for this article.
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27848243/proposed-algorithm-for-managing-ibrutinib-related-atrial-fibrillation
#11
Alaina Vrontikis, Jessica Carey, Jeffrey A Gilreath, Ahmad Halwani, Deborah M Stephens, John W Sweetenham
No abstract text is available yet for this article.
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27848242/jennifer-ligibel-discusses-new-data-strengthening-the-link-between-obesity-and-cancer
#12
Jennifer A Ligibel
No abstract text is available yet for this article.
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27753062/clotting-and-bleeding-in-oncology-patients-clinical-scenarios-and-challenges
#13
Kimberly M Komatsubara, David L Diuguid
No abstract text is available yet for this article.
October 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27753061/breast-cancer-brain-metastasis-an-ongoing-clinical-challenge-and-opportunity-for-innovation
#14
Heather McArthur
No abstract text is available yet for this article.
October 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27753060/multidisciplinary-management-of-breast-cancer-brain-metastases
#15
Timothy M Zagar, Amanda E D Van Swearingen, Orit Kaidar-Person, Matthew G Ewend, Carey K Anders
This review summarizes the most up-to-date approach to the multidisciplinary management of patients with breast cancer brain metastases. A brief overview of the epidemiology and biology of breast cancer brain metastasis is provided. The perspectives of radiation oncology, neurosurgery, and medical oncology-and landmark studies from each discipline-are all discussed. We also offer practical tips to help guide the treating physician, including data on antiseizure medications. Finally, we introduce the concept of a multidisciplinary clinic that combines input from medical and radiation oncology, neurosurgery, and support services, which we developed at the University of North Carolina as a coordinated and optimal approach to the management of patients with this complex disease...
October 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27753059/the-emerging-role-of-checkpoint-inhibitor-therapy-in-hodgkin-lymphoma
#16
Anita Kumar
No abstract text is available yet for this article.
October 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27753058/checkpoint-inhibition-in-hodgkin-lymphoma-saving-the-best-for-last
#17
Richard J Lin, Catherine S Diefenbach
Hodgkin lymphoma is a unique disease entity characterized by a low number of neoplastic tumor cells surrounded by an inflammatory microenvironment composed of dysfunctional immune cells. Recent molecular and genetic studies have revealed that upregulation of the immune checkpoint pathway programmed death 1/programmed death ligand 1 is a key oncogenic driver of Hodgkin lymphoma. Corroborating these mechanistic studies, early-phase clinical trials using the checkpoint inhibitors nivolumab and pembrolizumab in treatment regimens for relapsed and/or refractory Hodgkin lymphoma have demonstrated impressive response rates, a promising durability of response, and a favorable side-effect profile...
October 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27753057/clinical-hereditary-cancer-syndromes-and-gene-panel-testing
#18
Danielle N Sin, Julia A Smith
No abstract text is available yet for this article.
October 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27753056/prevention-and-screening-in-hereditary-breast-and-ovarian-cancer
#19
Simon B Zeichner, Christine Stanislaw, Jane L Meisel
In recent years, we have learned a great deal about pathogenic mutations that increase the risk of breast and ovarian cancer, particularly mutations in the BRCA1 and BRCA2 genes. Here we review current guidelines on breast and ovarian cancer screening, prophylactic surgery, and other risk-reduction strategies in patients with these mutations, and we detail the data that drive these recommendations. We also discuss guidelines on screening and management for other cancers associated with BRCA1 and BRCA2, such as male breast cancer, pancreatic cancer, and prostate cancer...
October 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27753055/counterpoint-surgical-management-of-lymph-node-basin-in-sentinel-lymph-node-positive-melanoma
#20
Merrick I Ross
No abstract text is available yet for this article.
October 15, 2016: Oncology (Williston Park, NY)
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