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International Journal of Geriatric Psychiatry

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https://www.readbyqxmd.com/read/28796303/measurement-tools-of-resource-use-and-quality-of-life-in-clinical-trials-for-dementia-or-cognitive-impairment-interventions-a-systematically-conducted-narrative-review
#1
REVIEW
Fan Yang, Piers Dawes, Iracema Leroi, Brenda Gannon
OBJECTIVE: Knowledge is limited about the standardised instruments used to collect resource use and quality of life data alongside trials of dementia interventions. This review aimed to identify the trials using such instruments in order to guide the design of future trial-based cost-effectiveness studies. METHODS: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement, this review examined all original, peer-reviewed research in major databases and general searches published until June 2017, including randomised clinical trials, pilot studies, or feasibility studies about interventions for older adults with dementia or cognitive impairment...
August 10, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28786127/the-impact-of-dementia-depression-and-awareness-on-activities-of-daily-living-in-a-sample-from-a-middle-income-country
#2
Daniel C Mograbi, Robin G Morris, Helenice Charchat Fichman, Camila Assis Faria, Maria Angélica Sanchez, Pricila C C Ribeiro, Roberto Alves Lourenço
OBJECTIVE: Previous studies have indicated that dementia and depression have a considerable impact on the functional capacity of older adults, also influencing awareness about ability. The purpose of the current study was to investigate the impact of dementia, depression and awareness on activities of daily living (ADL) in a sample from a middle-income country. METHODS: The current study explored impairments in basic, instrumental and advanced ADL using a factorial design comparing four groups: people with dementia and depression, people with dementia without depression, older adults with depression but no dementia and healthy older adults...
August 8, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28782132/aspirin-and-incident-depressive-symptoms-a-longitudinal-cohort-study-over-8%C3%A2-years
#3
Nicola Veronese, Ai Koyanagi, Brendon Stubbs, Marco Solmi, Michele Fornaro, Brisa F Fernandes, Christoph Muller, Trevor Thompson, André F Carvalho, Stefania Maggi
OBJECTIVE: Aspirin exhibits anti-atherosclerotic and anti-inflammatory properties-two potential risk factors for depression. The relationship between aspirin use and depression, however, remains unclear. We investigated whether the aspirin use is associated with a decreased incidence of depressive symptoms in a large North American cohort. METHODS: Data from the Osteoarthritis Initiative dataset, a multicenter, longitudinal study on community-dwelling adults was analyzed...
August 6, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28776766/utility-of-functioning-measures-in-the-prediction-of-independent-living-status-in-older-adults-with-serious-mental-illness
#4
Karen L Fortuna, Matthew C Lohman, Martha L Bruce, Stephen J Bartels
OBJECTIVE: The objective of the study was to compare the predictive utility of three commonly used functioning measures for people with serious mental illness in the prediction of independent living status. METHODS: We conducted a secondary data analysis from the Helping Older People Experience Success study with adults aged 50 years and older with a diagnosis of bipolar disorder, schizoaffective disorder, schizophrenia, or major depressive disorder (N = 183)...
August 4, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28766793/evaluation-of-a-carers-information-programme-culturally-adapted-for-south-asian-families
#5
Sahdia Parveen, Heather Blakey, Jan R Oyebode
OBJECTIVES: The Alzheimer's Society has culturally adapted an Information Programme for South Asian families (IPSAF) who support an individual living with dementia. The objectives of this evaluation were to establish whether IPSAF had an immediate and medium-term impact on those who attended and how it impacted on the wider family and the person with dementia. METHODS: An inclusive, pluralistic approach was adopted. Seven focus groups were conducted with 42 participants, and 37 participated in a pre-post knowledge quiz...
August 2, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28766755/does-baseline-depression-increase-the-risk-of-unexplained-and-accidental-falls-in-a-cohort-of-community-dwelling-older-people-data-from-the-irish-longitudinal-study-on-ageing-tilda
#6
Robert Briggs, Sean P Kennelly, Rose Anne Kenny
BACKGROUND: Depression independently increases the risk of falls in older people, but the mechanism for this relationship, as well as the specific falls type involved, remains unclear. Accidental falls (AFs) are due to slips or trips, while the cause of unexplained falls (UFs) is not immediately apparent and can include unrecognised syncope. METHOD: This longitudinal study examines the relationship between baseline depression and subsequent falls, both accidental and unexplained, at 2-year follow-up in a cohort of community dwelling adults aged ≥50 years...
August 2, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28758323/debate-article-antipsychotic-medications-are-clinically-useful-for-the-treatment-of-delirium
#7
David Meagher, Meera R Agar, Andrew Teodorczuk
Prescribing of antipsychotic medications for patients with delirium remains controversial. Concerns exist that these vulnerable and frail patients may be prescribed antipsychotics inappropriately as a substitute for non-pharmacological approaches when identifiable causes are not found or they challenge ward processes. Moreover, recent evidence suggests that antipsychotics may cause more harm than good in the palliative care patient group with delirium. On the other hand, guidelines in the United Kingdom and the Netherlands support prescribing of antipsychotics in certain circumstances, and a large European survey has revealed that antipsychotics tend to be prescribed first line for hyperactive delirium...
July 30, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28741698/the-relationship-between-vision-impairment-and-well-being-among-centenarians-findings-from-the-georgia-centenarian-study
#8
Aya Toyoshima, Peter Martin, Shinichi Sato, Leonard W Poon
OBJECTIVE: The current study evaluated the visual function among centenarians and assessed the relationship between vision, social support, and well-being. METHODS: This study used the data set of the Georgia Centenarian Study including 106 centenarians (18 men and 88 women). We used scores of the Snellen chart for objective vision and self-reports for subjective vision. Social support, depression, and loneliness were also assessed. RESULTS: Approximately 75% of the centenarians showed some level of objective visual impairment, and 56% of them reported that they had visual impairment...
July 25, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28741694/reduced-parahippocampal-volume-and-psychosis-symptoms-in-alzheimer-s-disease
#9
Emma McLachlan, Jennifer Bousfield, Robert Howard, Suzanne Reeves
OBJECTIVE: Establishing structural imaging correlates of psychosis symptoms in Alzheimer's disease (AD) could localise pathology and target symptomatic treatment. This study investigated whether psychosis symptoms are associated with visuoperceptual or frontal networks, and whether regional brain volume differences could be linked with the paranoid (persecutory delusions) or misidentification (misidentification phenomena and/or hallucinations) subtypes. METHODS: A total of 104 patients with probable AD (AddNeuroMed; 47 psychotic, 57 non-psychotic), followed up for at least one year with structural MRI at baseline...
July 25, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28736899/trajectories-of-depressive-and-anxiety-symptoms-in-older-adults-a-6-year-prospective-cohort-study
#10
Sophie E Holmes, Irina Esterlis, Carolyn M Mazure, Yen Ying Lim, David Ames, Stephanie Rainey-Smith, Chris Fowler, Kathryn Ellis, Ralph N Martins, Olivier Salvado, Vincent Doré, Victor L Villemagne, Christopher C Rowe, Simon M Laws, Colin L Masters, Robert H Pietrzak, Paul Maruff
OBJECTIVE: Depressive and anxiety symptoms are common in older adults, significantly affect quality of life, and are risk factors for Alzheimer's disease. We sought to identify the determinants of predominant trajectories of depressive and anxiety symptoms in cognitively normal older adults. METHOD: Four hundred twenty-three older adults recruited from the general community underwent Aβ positron emission tomography imaging, apolipoprotein and brain-derived neurotrophic factor genotyping, and cognitive testing at baseline and had follow-up assessments...
July 24, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28731508/a-re-examination-of-montreal-cognitive-assessment-moca-cutoff-scores
#11
Nicole Carson, Larry Leach, Kelly J Murphy
OBJECTIVE: The Montreal Cognitive Assessment (MoCA; Nasreddine et al., 2005) is a cognitive screening tool that aims to differentiate healthy cognitive aging from Mild Cognitive Impairment (MCI). Several validation studies have been conducted on the MoCA, in a variety of clinical populations. Some studies have indicated that the originally suggested cutoff score of 26/30 leads to an inflated rate of false positives, particularly for those of older age and/or lower education. We conducted a systematic review and meta-analysis of the literature to determine the diagnostic accuracy of the MoCA for differentiating healthy cognitive aging from possible MCI...
July 21, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28657697/vascular-risk-factors-in-older-patients-with-depression-outcome-of-electroconvulsive-therapy-versus-medication
#12
Harm-Pieter Spaans, Rob M Kok, Filip Bouckaert, Julia F Van Den Berg, Orlaith C Tunney, Pascal Sienaert, Esmée Verwijk, King H Kho, Max L Stek
OBJECTIVE: Research suggests that in depression, vascular burden predicts a lower efficacy for medication (MED) and a more favourable outcome for electroconvulsive therapy (ECT). Therefore, we investigated the influence of the following vascular risk factors (VRF): hypercholesterolemia, hypertension, smoking, diabetes mellitus, cardiovascular disease, and cerebral vascular accident/transient ischemic attack, on remission from major depression after ECT versus MED. METHODS: The study sample consisted of 81 inpatients with a DSM-IV unipolar major depression diagnosis (mean age 72...
June 28, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28643948/investigating-the-separate-and-interactive-associations-of-trauma-and-depression-on-brain-structure-implications-for-cognition-and-aging
#13
Aimee J Karstens, Olusola Ajilore, Leah H Rubin, Shaolin Yang, Aifeng Zhang, Alex Leow, Anand Kumar, Melissa Lamar
OBJECTIVE: Trauma and depression are associated with brain structural alterations; their combined effects on these outcomes are unclear. We previously reported a negative effect of trauma, independent of depression, on verbal learning and memory; less is known about underlying structural associates. We investigated separate and interactive associations of trauma and depression on brain structure. METHODS: Adults aged 30-89 (N = 203) evaluated for depression (D+) and trauma history (T+) using structured clinical interviews were divided into 53 D+T+, 42 D+T-, 50 D-T+, and 58 D-T-...
June 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28643900/exploring-perspectives-of-young-onset-dementia-caregivers-with-high-versus-low-unmet-needs
#14
Joany K Millenaar, Christian Bakker, Deliane van Vliet, Raymond T C M Koopmans, Alexander Kurz, Frans R J Verhey, Marjolein E de Vugt
BACKGROUND: This study is part of the Research to Assess Policies and Strategies for Dementia in the Young project. Information about specific needs in young onset dementia (YOD) will provide the basis for the development of an e-health intervention to assist caregivers in coping with YOD in several European countries. OBJECTIVE: The aim was to investigate the issues caregivers of people with YOD face. METHODS: A qualitative content analysis method was used to analyse interviews with YOD caregivers...
June 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28643852/therapeutic-d2-3-receptor-occupancies-and-response-with-low-amisulpride-blood-concentrations-in-very-late-onset-schizophrenia-like-psychosis-vloslp
#15
Suzanne Reeves, Kate Eggleston, Elizabeth Cort, Emma McLachlan, Stuart Brownings, Akshay Nair, Suki Greaves, Alan Smith, Joel Dunn, Paul Marsden, Robert Kessler, David Taylor, Julie Bertrand, Robert Howard
OBJECTIVE: Antipsychotic drug sensitivity in very late-onset schizophrenia-like psychosis (VLOSLP) is well documented, but poorly understood. This study aimed to investigate blood drug concentration, D2/3 receptor occupancy and outcome in VLOSLP during open amisulpride prescribing, and compare this with Alzheimer's disease (AD). METHODS: Blood drug concentration, prolactin, symptoms and extrapyramidal side-effects (EPS) were serially assessed during dose titration...
June 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28639724/longitudinal-changes-in-global-and-domain-specific-cognitive-function-in-the-very-old-findings-from-the-newcastle-85-study
#16
Blossom C M Stephan, Graciela Muniz-Terrera, Antoneta Granic, Joanna Collerton, Karen Davies, Brian K Saxby, Keith A Wesnes, Thomas B L Kirkwood, Carol Jagger
OBJECTIVE: Ageing is associated with changes in cognition in some, but not all domains. In young-old adults, defined as persons aged 65-84 years, baseline cognitive function has been shown to impact on cognitive trajectories. Whether similar patterns occur in the very-old, defined as persons aged 85 years and over, is not known. METHODS: Longitudinal changes (5 years' follow-up) in global and domain specific cognitive function including memory, attention and speed were investigated in participants from the Newcastle 85+ Study (n = 845)...
June 22, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28639714/plasma-cytokine-il-6-levels-and-subjective-cognitive-decline-preliminary-findings
#17
Andrew P Keegan, Daniel Paris, Cheryl A Luis, Laila Abdullah, Ghania Ait-Ghezala, David Beaulieu-Abdelahad, Makenzie Pryor, Jillian Chaykin, Gogce Crynen, Fiona Crawford, Michael Mullan
OBJECTIVE: Detection of Alzheimer's disease (AD) prior to clinical inception will be paramount for introducing disease modifying treatments. We have begun collecting baseline characteristics of a community cohort for longitudinal assessment and testing of antecedent blood-based biomarkers. We describe the baseline visit from the first 131 subjects in relationship to a commonly described cytokine, interleukin 6 (IL-6). METHODS: Subjects from the community presented for a free memory screening with varying degrees of memory concern...
June 22, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28639712/the-effect-of-childcare-activities-on-cognitive-status-and-depression-in-older-adults-gender-differences-in-a-4-4-year-longitudinal-study
#18
Caterina Trevisan, Maria Valentina Pamio, Chiara Curreri, Stefania Maggi, Giovannella Baggio, Sabina Zambon, Leonardo Sartori, Egle Perissinotto, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi
OBJECTIVES: Although involvement in childcare activities seems to promote better physical and mental health in older adults, its impact on cognitive status and depression has not yet been fully elucidated. We aimed to analyze the association between engagement in childcare activities and cognitive and psychological status over a 4.4-year period in community-dwelling older adults. METHODS: Two thousand one hundred four subjects older than 65 years without severe cognitive impairment at baseline were categorized according to the frequency of their involvement in childcare activities (everyday, occasionally, never)...
June 22, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28639286/provision-and-perceived-quality-of-mental-health-services-for-older-care-home-residents-in-england-a-national-survey
#19
Karen Stewart, Claire Hargreaves, Rowan Jasper, David Challis, Sue Tucker, Mark Wilberforce
OBJECTIVE: This study examined the nature, extent and perceived quality of the support provided by community mental health teams for older people (CMHTsOP) to care home residents. METHODS: A postal survey was sent to all CMHTsOP in England. Information was collected about teams' staffing and their involvement in case finding, assessment, medication reviews, care planning and training as well as team managers' rating of the perceived quality of the service they provided for care home residents...
June 22, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28627719/the-frontal-assessment-battery-in-clinical-practice-a-systematic-review
#20
REVIEW
Miriam Hurtado-Pomares, M Carmen Terol-Cantero, Alicia Sánchez-Pérez, Paula Peral-Gómez, Desirée Valera-Gran, Eva María Navarrete-Muñoz
BACKGROUND: The frontal assessment battery (FAB) is a brief tool designed to evaluate executive function. Some studies have particularly focused on assessing its applicability addressing two issues: first, on detecting the brain regions responsible for the FAB performance, and second, on determining its capability for differential diagnosis. Our aim was to summarize and analyze critically the studies that assessed the neuroanatomical correspondence and the differential diagnostic value of the FAB in several study populations suffering from different pathologies...
June 19, 2017: International Journal of Geriatric Psychiatry
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