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International Journal of Geriatric Psychiatry

Lotte Berk, Martin van Boxtel, Sebastian Köhler, Jim van Os
OBJECTIVE: In cross-sectional studies, positive affect (PA) has been associated with higher levels of cognitive functioning. This study examined whether positive affect (PA) is associated with change in cognitive function over 12 years in an adult population sample. METHODS: Participants (n = 258), aged 40 to 82 years, were drawn from a subsample of the Maastricht Aging Study (MAAS) and assessed at baseline, 6 years and 12 years. PA was measured at baseline with a Dutch translation of the Positive and Negative Affect Schedule (PANAS)...
October 17, 2016: International Journal of Geriatric Psychiatry
Alexandra S Creighton, Tanya E Davison, David W Kissane
OBJECTIVE: To synthesize and summarize the studies examining the correlates and predictors of anxiety in older adults living in residential aged care. METHODS: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, five electronic databases were searched using key terms and subject headings, as well as reference lists of relevant papers. The search was limited to peer-reviewed literature published in English. Eligible studies examined the association between at least one correlate/factor and anxiety disorders or symptoms in aged care residents aged 50+ years...
October 17, 2016: International Journal of Geriatric Psychiatry
Martin Knapp, Derek King, Renée Romeo, Jessica Adams, Ashley Baldwin, Clive Ballard, Sube Banerjee, Robert Barber, Peter Bentham, Richard G Brown, Alistair Burns, Tom Dening, David Findlay, Clive Holmes, Tony Johnson, Robert Jones, Cornelius Katona, James Lindesay, Ajay Macharouthu, Ian McKeith, Rupert McShane, John T O'Brien, Patrick P J Phillips, Bart Sheehan, Robert Howard
OBJECTIVE: Most investigations of pharmacotherapy for treating Alzheimer's disease focus on patients with mild-to-moderate symptoms, with little evidence to guide clinical decisions when symptoms become severe. We examined whether continuing donepezil, or commencing memantine, is cost-effective for community-dwelling, moderate-to-severe Alzheimer's disease patients. METHODS: Cost-effectiveness analysis was based on a 52-week, multicentre, double-blind, placebo-controlled, factorial clinical trial...
October 13, 2016: International Journal of Geriatric Psychiatry
Sube Banerjee, Nicolas Farina, Stephanie Daley, Wendy Grosvenor, Leila Hughes, Molly Hebditch, Sophie Mackrell, Ramin Nilforooshan, Chris Wyatt, Kay de Vries, Inam Haq, Juliet Wright
OBJECTIVES: Traditional healthcare education, delivered through a series of time-limited clinical placements, often fails to deliver an understanding of the experiences of those with long-term conditions, a growing issue for healthcare systems. Responses include longitudinal integrated clerkships and senior mentor programmes allowing students' longer placements, continuity of contact and opportunities to learn about chronic illness and patient experience. We review their development and delivery in dementia and present the Time for Dementia (TFD) Programme, a novel 2-year interdisciplinary educational programme...
October 10, 2016: International Journal of Geriatric Psychiatry
Frédéric Bloch
OBJECTIVE: To test the hypothesis that post-traumatic stress disorder (PTSD) can appear after a fall and try to identify predictive factors for its development in older fallers. METHODS: Systematic literature review and meta-analyses of studies on PTSD post fall in older subjects. RESULTS: One hundred seventy-seven indexed articles were identified, of which three had complete data on PTSD post fall in older subjects. Only the odds ratio of the association between history of fall and occurrence of PTSD was significant (odds ratio = 2...
October 10, 2016: International Journal of Geriatric Psychiatry
Helen Costello, Gillian M Hayes, Elizabeth Highton-Williamson, Shirley Nurock, Dave Hanbury, Paul T Francis
OBJECTIVE: Test the feasibility of assessing cognition, psychiatric symptoms and daily living skills of potential brain donors by telephone and compare satisfaction and attitudes across telephone and face-to-face assessment. METHOD: Data were collected from 108 healthy participants from the Brains for Dementia Research cohort. Purposive sampling was used to assess feasibility and a randomised control trial design compared satisfaction and attitudes towards telephone and face-to-face assessment...
October 7, 2016: International Journal of Geriatric Psychiatry
Tomoyuki Nagata, Shinichiro Nakajima, Shunichiro Shinagawa, Eric Plitman, Ariel Graff-Guerrero, Masaru Mimura, Kazuhiko Nakayama
OBJECTIVE: This study sought to determine psychosocial and clinico-demographic factors related to each symptomatic cluster (i.e., aggressiveness, psychosis, apathy/eating problems, and emotion/disinhibition) of neuropsychiatric symptoms (NPSs) in patients with Alzheimer's disease (AD) needing interventional treatment against their agitation or psychotic symptoms. These clusters were classified from 12 Neuropsychiatric Inventory (NPI) subscores in our previous study using the Clinical Antipsychotic Trials of Intervention Effectiveness-Alzheimer's Disease (CATIE-AD) dataset...
October 7, 2016: International Journal of Geriatric Psychiatry
J B Blok, J G M Scheirs, N S Thijm
OBJECTIVE: The objective was to find out whether changes in personality and adaptive functioning or memory processes decline first in ageing people with Down syndrome. METHODS: We measured these variables cross-sectionally in a Dutch sample (22 to 62 years of age) of 68 institutionalised people with Down syndrome. RESULTS: The scores on all the variables except one of the temperament scales were found to decline gradually with increasing age, but deterioration of episodic memory started earlier...
October 4, 2016: International Journal of Geriatric Psychiatry
Yoshihide Takeshita, Nobuto Shibata, Koji Kasanuki, Tomoyuki Nagata, Shunichiro Shinagawa, Nobuyuki Kobayashi, Tohru Ohnuma, Ayako Suzuki, Eri Kawai, Toshiki Takayama, Kenya Nishioka, Yumiko Motoi, Nobutaka Hattori, Kazuhiko Nakayama, Hisashi Yamada, Heii Arai
BACKGROUND/AIMS: Interaction of receptor for advanced glycation end products (RAGE) with amyloid-β increases amplification of oxidative stress and plays pathological roles in Alzheimer's disease (AD). Oxidative stress leads to α-synuclein aggregation and is also a major contributing factor in the pathogenesis of Lewy body dementias (LBDs). Therefore, we aimed to investigate whether RAGE gene polymorphisms were associated with AD and LBDs. METHODS: Four single nucleotide polymorphisms (SNPs)-rs1800624, rs1800625, rs184003, and rs2070600-of the gene were analyzed using a case-control study design comprising 288 AD patients, 76 LBDs patients, and 105 age-matched controls...
October 4, 2016: International Journal of Geriatric Psychiatry
Ryan M Silwanowicz, Donovan T Maust, Lisa S Seyfried, Claire Chiang, Claire Stano, Helen C Kales
OBJECTIVE: Our aim is to evaluate if and how neuropsychiatric symptoms (NPS) of dementia influence the management and disposition of older adults who present to emergency care settings. METHODS: This is a retrospective cohort study that involved the medical and psychiatric emergency departments of a tertiary academic medical center. Participants included patients ≥65 years of age with dementia who presented between 1 February 2012 and 16 July 2014 (n = 347)...
October 4, 2016: International Journal of Geriatric Psychiatry
D M O'Shea, V M Dotson, R A Fieo
OBJECTIVE: Personality traits have been shown to be predictors of depressive symptoms in late life. Thus, we examined whether other more modifiable sources of individual differences such as self-efficacy and self-perceptions of aging would mediate the association between personality traits and depressive symptoms in older adults. METHOD: Data were obtained from 3,507 older adult participants who took part in the 2012 Health and Retirement Study. The "Big Five" personality traits, self-efficacy, aging perceptions, and depressive symptoms were assessed...
September 21, 2016: International Journal of Geriatric Psychiatry
Lisa C Barry, Dorothy B Wakefield, Robert L Trestman, Yeates Conwell
OBJECTIVE: The study objective was to determine if disability in activities of daily living specific to prison, prison activities of daily living (PADLs), is associated with depression and severity of suicidal ideation (SI) in older prisoners, a rapidly growing population at high risk of suicide. METHODS: Cross-sectional design using data from a study of prisoners age ≥50 years (N = 167). Depression was operationalized as a score of ≥15 on the 9-item Physician Health Questionnaire (PHQ-9)...
September 21, 2016: International Journal of Geriatric Psychiatry
O Zubko, R L Gould, H C Gay, H J Cox, M C Coulson, R J Howard
BACKGROUND AND OBJECTIVE: Current treatments for Alzheimer's Disease (AD) do not affect the course of the illness and brain stimulation techniques are increasingly promoted as potential therapeutic interventions for AD. This study reviews the effects of electromagnetic field (EMF) exposure versus sham exposure on working memory (WM) performance of healthy human participants. METHOD: Online literature databases and previous systematic reviews were searched for studies of EMF and WM in participants without reported memory problems...
September 20, 2016: International Journal of Geriatric Psychiatry
Stephen F Smagula, Helmet T Karim, Eric J Lenze, Meryl A Butters, Gregory F Wu, Benoit H Mulsant, Charles F Reynolds, Howard J Aizenstein
OBJECTIVE: Eotaxin is a chemokine that exerts negative effects on neurogenesis. We recently showed that peripheral eotaxin levels correlate with both lower gray matter volume and poorer executive performance in older adults with major depressive disorder. These findings suggest that the relationship between eotaxin and set-shifting may be accounted for by lower gray matter volume in specific regions. Prior studies have identified specific gray matter regions that correlate with set-shifting performance, but have not examined whether these specific gray matter regions mediate the cross-sectional association between eotaxin and set-shifting...
September 19, 2016: International Journal of Geriatric Psychiatry
Yuan-Yuan Wang, Wei Zheng, Chee H Ng, Gabor S Ungvari, Wei Wei, Yu-Tao Xiang
OBJECTIVE: This is a meta-analysis of randomized controlled trials (RCTs) of the efficacy of melatonin in Alzheimer's disease (AD). METHODS: Both English (PubMed, PsycINFO, Embase, Cochrane Library databases, and the Cochrane Controlled Trials Register) and Chinese (WanFang Database, Chinese Biomedical Database, and China Journal Net) databases were systematically and independently searched by two authors from their inception until 1 March 2016. Weighted and standard mean differences (SMDs), risk ratio (RR) ±95% confidence intervals (CIs) were calculated...
September 19, 2016: International Journal of Geriatric Psychiatry
Clive Ballard, Martin Orrell, Yongzhong Sun, Esme Moniz-Cook, Jane Stafford, Rhiannon Whitaker, Bob Woods, Anne Corbett, Sube Banerjee, Ingelin Testad, Lucy Garrod, Zunera Khan, Barbara Woodward-Carlton, Jennifer Wenborn, Jane Fossey
BACKGROUND: Very few interventional studies have directly examined the impact of treatment approaches on health-related quality of life (HRQL) in people with dementia. This is of particular importance in therapies to address behavioural symptoms, where HRQL is often severely affected. METHODS: Analysis within the WHELD cluster randomised factorial study in 16 UK care homes examining the impact of person-centred care in combination with antipsychotic review, social interaction and exercise interventions...
September 19, 2016: International Journal of Geriatric Psychiatry
Kamel Gana, Nathalie Bailly, Guillaume Broc, Christophe Cazauvieilh, Nedjem Eddine Boudouda
OBJECTIVE: Self-report measures of depression are highly important tools used in research and in various healthcare settings for the diagnosis of different levels of depression. The Geriatric Depression Scale (GDS) is the first and the most popular scale used to screen for late-life depression. It is endorsed by the Royal College of Physicians and the British Geriatric Society (1992). The purpose of the present research was to investigate whether scores on the GDS15 capture depressive mood (i...
September 15, 2016: International Journal of Geriatric Psychiatry
Claudio Di Lorito, Linda Birt, Fiona Poland, Emese Csipke, Dianne Gove, Ana Diaz-Ponce, Martin Orrell
BACKGROUND: There is limited literature around peer research in dementia. This study aims to identify the benefits, the risks and the practical challenges and to develop a model of good practice in peer research with people with dementia. METHODS: We searched on PsycInfo, PubMed and Google Scholar for empirical investigations or discussion papers on peer research. Given the limited literature in the field of dementia, we included studies with groups who share similar demographics (older people), experience of stigma (mental health service users) and exclusion from research (people with learning disabilities)...
September 15, 2016: International Journal of Geriatric Psychiatry
Ai Sakamoto, Shigekazu Ukawa, Emiko Okada, Sachiko Sasaki, Wenjing Zhao, Tomoko Kishi, Katsunori Kondo, Akiko Tamakoshi
OBJECTIVE: To study the association between the number of area-level and individual-level social participation items and cognitive function in the community-dwelling older populations of three towns in Hokkaido, Japan. METHODS: A survey on the frequency of social participation was mailed to those in the Japan Gerontological Evaluation Study 2013 who were aged ≥65 years, were not certified as needing long-term care, and lived in Higashikawa, Higashikagura, or Biei...
September 9, 2016: International Journal of Geriatric Psychiatry
Brian Downer, Nai-Wei Chen, Mukaila Raji, Kyriakos S Markides
OBJECTIVE: To identify distinct trajectories for global cognition, memory, and non-memory domains among Mexican American adults 75 years of age and older. METHODS: The final sample included 1336 participants of the Hispanic Established Population for the Epidemiologic Study of the Elderly observed during four Waves from 2004-2005 to 2012-2013. Latent class growth curve models were used to identify distinct trajectories for global cognition, memory, and non-memory...
September 6, 2016: International Journal of Geriatric Psychiatry
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