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International Journal of Geriatric Psychiatry

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https://www.readbyqxmd.com/read/28317166/the-relationship-of-specific-items-on-the-neuropsychiatric-inventory-to-caregiver-burden-in-dementia-a-systematic-review
#1
REVIEW
Toril Marie Terum, John Roger Andersen, Arvid Rongve, Dag Aarsland, Ellen J Svendsboe, Ingelin Testad
OBJECTIVE: Neuropsychiatric symptoms (NPSs) are common in dementia, and they have been identified as important care-recipient variables in terms of their impact on caregiver burden. The aim of this review was to describe how individual NPSs in dementia, assessed using the Neuropsychiatric Inventory, are associated with caregiver burden. METHODS: We performed a systematic review of English language, peer-reviewed articles retrieved from MEDLINE, PSYCINFO, and EMBASE...
March 20, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28299814/functional-neuroanatomical-associations-of-working-memory-in-early-onset-alzheimer-s-disease
#2
Christopher Kobylecki, Cathleen Haense, Jennifer M Harris, Cheryl L Stopford, Shailendra H Segobin, Matthew Jones, Anna M T Richardson, Alexander Gerhard, José Anton-Rodriguez, Jennifer C Thompson, Karl Herholz, Julie S Snowden
OBJECTIVE: To characterize metabolic correlates of working memory impairment in clinically defined subtypes of early-onset Alzheimer's disease. BACKGROUND: Established models of working memory suggest a key role for frontal lobe function, yet the association in Alzheimer's disease between working memory impairment and visuospatial and language symptoms suggests that temporoparietal neocortical dysfunction may be responsible. METHODS: Twenty-four patients with predominantly early-onset Alzheimer's disease were clinically classified into groups with predominantly amnestic, multidomain or visual deficits...
March 16, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28295599/gender-difference-in-the-association-and-presentation-of-visual-hallucinations-in-dementia-with-lewy-bodies-a-cross-sectional-study
#3
Pai-Yi Chiu, Po-Ren Teng, Cheng-Yu Wei, Chein-Wei Wang, Chun-Tang Tsai
OBJECTIVE: Visual hallucinations (VHs) are among the most striking features of dementia with Lewy bodies (DLB). We investigated gender differences in the association and presentation of VHs in DLB. METHODS: A cross-sectional analysis of baseline data from a prospective, longitudinal study on dementia was performed. Cumulative frequency, 1-month frequency, and phenomenology of VHs were summarized and compared between female and male patients with DLB. Gender differences in the factors associated with VHs were investigated in patients with and without hallucinations...
March 13, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28295591/acetylcholinesterase-inhibitors-for-electroconvulsive-therapy-induced-cognitive-side-effects-a-systematic-review
#4
REVIEW
Marieke J Henstra, Elise P Jansma, Nathalie van der Velde, Eleonora L Swart, Max L Stek, Didi Rhebergen
OBJECTIVE: Electroconvulsive therapy (ECT) is an effective treatment for severe late-life depression; however, ECT-induced cognitive side effects frequently occur. The cholinergic system is thought to play an important role in the pathogenesis. We systematically reviewed the evidence for acetylcholinesterase inhibitors (Ache-I) to prevent or reduce ECT-induced cognitive side effects. METHODS: A systematic search was performed in Pubmed, EMBASE, PsychINFO, and the Cochrane database to identify clinical trials investigating the effect of Ache-I on ECT-induced cognitive side effects...
March 10, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28271556/where-next-for-delirium-research
#5
Rowan H Harwood, Elizabeth Teale
Clinicians who manage delirium must do so without key information required for evidence-based practice, not least lack of any clearly effective treatment for established delirium. Both the nature of delirium and the methods used to research it contribute to difficulties. Delirium is heterogeneous, with respect to motor subtype, aetiology, setting and the co-existence of dementia, and may be almost inevitable towards the end of life. Elements of assessment are subjective, so diagnosis can be uncertain or unreliable...
March 8, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28271543/associations-between-pro-inflammatory-cytokines-learning-and-memory-in-late-life-depression-and-healthy-aging
#6
Rebecca A Charlton, Melissa Lamar, Aifeng Zhang, Xinguo Ren, Olusola Ajilore, Ghanshyam N Pandey, Anand Kumar
OBJECTIVES: Pro-inflammatory cytokines may play a role in learning and memory difficulties and may be exacerbated in late-life depression (LLD), where pro-inflammatory markers are already elevated because of aging and age-related vascular risk. METHODS: Learning and memory, and pro-inflammatory cytokines-Interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and Interleukin-6 (IL-6) were measured in 24 individuals with LLD and 34 healthy older adults (HOA)...
March 8, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28247500/lifestyle-for-brain-health-libra-a-new-model-for-dementia-prevention
#7
Olga J G Schiepers, Sebastian Köhler, Kay Deckers, Kate Irving, Catherine A O'Donnell, Marjan van den Akker, Frans R J Verhey, Stephanie J B Vos, Marjolein E de Vugt, Martin P J van Boxtel
OBJECTIVE: Modifiable risk factors for dementia were recently identified and compiled in a systematic review. The 'Lifestyle for Brain Health' (LIBRA) score, reflecting someone's potential for dementia prevention, was studied in a large longitudinal population-based sample with respect to predicting cognitive change over an observation period of up to 16 years. METHODS: Lifestyle for Brain Health was calculated at baseline for 949 participants aged 50-81 years from the Maastricht Ageing Study...
February 28, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28247480/apathy-dimensions-in-parkinson-s-disease
#8
Ratko Radakovic, Richard Davenport, John M Starr, Sharon Abrahams
OBJECTIVE: Apathy is a prominent and disabling symptom in Parkinson's disease (PD) and is a multidimensional behaviour, but which dimensions are specifically affected is unclear. Therefore, the aim of this preliminary study was to determine the psychometric properties of the Dimensional Apathy Scale (DAS) and explore the multidimensional profile of apathy in PD patients. METHODS: Thirty-four PD patients, with 30 of their informants/carers, and 34 healthy controls, with 30 of their informants, completed the DAS, Apathy Evaluation Scale and the Geriatric Depression Scale Short Form...
February 28, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28240415/the-impact-of-anxiety-on-the-progression-of-mild-cognitive-impairment-to-dementia-in-chinese-and-english-data-bases-a-systematic-review-and-meta-analysis
#9
Xiao-Xue Li, Zheng Li
OBJECTIVE: It remains unclear whether or not anxiety increases the risk of dementia in people with mild cognitive impairment (MCI). The aim of this systematic review and meta-analysis was to investigate the risk of dementia among people with MCI and anxiety compared with those with MCI and no anxiety. METHODS: The hazard ratio of conversion to dementia in people with anxiety and MCI was compared with those without anxiety and was calculated using a generic inverse variance method with fixed effect models...
February 27, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28240379/different-apathy-clinical-profile-and-neural-correlates-in-behavioral-variant-frontotemporal-dementia-and-alzheimer-s-disease
#10
Marta Fernández-Matarrubia, Jordi A Matías-Guiu, María Nieves Cabrera-Martín, Teresa Moreno-Ramos, María Valles-Salgado, José Luis Carreras, Jorge Matías-Guiu
OBJECTIVES: Apathy is one of the most common and disabling syndromes of dementia. Clinical apathy expression and neuroanatomical basis of apathy seem to differ between behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD), although evidence is scarce and poorly understood. Our main purposes were to compare the clinical apathy profile from patients with bvFTD and AD and analyze the relationship between apathy and brain metabolism measured using positron emission tomography imaging with (18) F fluorodeoxyglucose (FDG-PET)...
February 27, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28240378/coronary-artery-calcification-and-cognitive-function-cross-sectional-results-from-the-elsa-brasil-study
#11
Claudia K Suemoto, Marcio S Bittencourt, Itamar S Santos, Isabela M Benseñor, Paulo A Lotufo
OBJECTIVES: We examined the relationship between coronary artery calcification (CAC) score and performance in cognitive tests in a large Brazilian sample. METHODS: In this cross-sectional study, 4104 participants (mean age = 50.9 ± 8.8 years old, 54% female) from the Brazilian Longitudinal Study of Adult Health had complete information for CAC and cognitive tests. We used linear regression models adjusted for sociodemographics, cardiovascular risk factors (hypertension, diabetes, smoking, alcohol use, physical activity, and body mass index), depression, and thyroid function...
February 27, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28239920/neuropsychiatric-symptoms-in-south-east-asian-patients-with-mild-cognitive-impairment-and-dementia-prevalence-subtypes-and-risk-factors
#12
Chathuri Yatawara, Shaun Hiu, Laura Tan, Nagaendran Kandiah
BACKGROUND: The subtypes and risk factors of neuropsychiatric symptoms remain largely unexplored in South-East Asian populations. OBJECTIVE: We investigated the prevalence, subtypes, and risk factors, namely, demographic, medical morbidity, and cognitive impairment associated with neuropsychiatric symptoms in a South-East Asian cohort of patients with mild cognitive impairment (MCI) and dementia. METHODS: A clinical cohort of 38 MCI and 198 mild-moderate dementia patients were assessed using the Neuropsychiatric Inventory-Questionnaire...
February 27, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28239906/complementary-medicine-for-treatment-of-agitation-and-delirium-in-older-persons-a-systematic-review-and-narrative-synthesis
#13
REVIEW
Ilana Levy, Samuel Attias, Eran Ben-Arye, Boaz Bloch, Elad Schiff
BACKGROUND: Agitation and delirium frequently occur in cognitively impaired older people. We conducted a systematic review with narrative synthesis of the literature aiming to assess effectiveness of complementary and alternative medicine (CAM) modalities to address these conditions. METHODS: Following preliminary search, we included 40 original researches on CAM treatment of delirium and agitation in older persons. Then, the quality of these studies was assessed using the Downs and Black Checklist and Quality Assessment Tool for Studies with Diverse Designs, and the effect sizes were calculated...
February 26, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28233343/a-pilot-randomized-trial-of-two-cognitive-rehabilitation-interventions-for-mild-cognitive-impairment-caregiver-outcomes
#14
Andrea V Cuc, Dona E C Locke, Noah Duncan, Julie A Fields, Charlene Hoffman Snyder, Sherrie Hanna, Angela Lunde, Glenn E Smith, Melanie Chandler
OBJECTIVE: This study aims to provide effect size estimates of the impact of two cognitive rehabilitation interventions provided to patients with mild cognitive impairment: computerized brain fitness exercise and memory support system on support partners' outcomes of depression, anxiety, quality of life, and partner burden. METHODS: A randomized controlled pilot trial was performed. RESULTS: At 6 months, the partners from both treatment groups showed stable to improved depression scores, while partners in an untreated control group showed worsening depression over 6 months...
February 24, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28220964/effects-of-mind-body-interventions-on-depressive-symptoms-among-older-chinese-adults-a-systematic-review-and-meta-analysis
#15
REVIEW
Ai Bo, Weiyu Mao, Michael A Lindsey
OBJECTIVE: To determine the efficacy of mind-body interventions in depressive symptoms treatment among older Chinese adults (>60 years of age). METHODS: We searched MEDLINE, PsycINFO (Ovid), Embase (Ovid), CINAHL, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Wanfang Data, Chinese Biomedical Literature Database, and Chongqing VIP for eligible studies until September 2016. We reviewed randomized controlled trials investigating the efficacy of mind-body interventions for depressive symptoms among Chinese older adults...
February 21, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28220957/the-association-of-a-heart-attack-or-stroke-with-depressive-symptoms-stratified-by-the-presence-of-a-close-social-contact-findings-from-the-national-health-and-aging-trends-study-cohort
#16
Adam Simning, Christopher L Seplaki, Yeates Conwell
OBJECTIVE: The objective of the study is to examine whether the risk of having clinically significant depressive symptoms following a heart attack or stroke varies by the presence of a close social contact. METHODS: The National Health and Aging Trends Study is a nationally representative longitudinal survey of US Medicare beneficiaries aged 65 and older initiated in 2011. A total of 5643 older adults had information on social contacts at baseline and depressive symptoms at the 1-year follow-up interview...
February 21, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28217838/the-experiences-of-people-with-dementia-and-their-carers-participating-in-individual-cognitive-stimulation-therapy
#17
Phuong Leung, Lauren Yates, Vasiliki Orgeta, Fara Hamidi, Martin Orrell
BACKGROUND: The carer-delivered individual cognitive stimulation therapy (iCST) was developed to improve cognition and quality of life of people with dementia. This study aims to explore people with dementia and family carers' concepts of mental stimulation and experiences of participating in the iCST intervention. METHODS: A sub-sample of 23 dyads of people with dementia and their family carers who completed the iCST intervention took part in semi-structured in-depth interviews...
February 20, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28206715/housing-first-for-older-homeless-adults-with-mental-illness-a-subgroup-analysis-of-the-at-home-chez-soi-randomized-controlled-trial
#18
Timothy E Chung, Agnes Gozdzik, Luis I Palma Lazgare, Matthew J To, Tim Aubry, James Frankish, Stephen W Hwang, Vicky Stergiopoulos
OBJECTIVE: This study compares the effect of Housing First on older (≥50 years old) and younger (18-49 years old) homeless adults with mental illness participating in At Home/Chez Soi, a 24-month multisite randomized controlled trial of Housing First. METHOD: At Home/Chez Soi, participants (n = 2148) were randomized to receive rent supplements with intensive case management or assertive community treatment, based on their need level for mental health services, or usual care in their respective communities...
February 16, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28198046/muscle-fatigability-and-depressive-symptoms-in-later-life
#19
Patrick J Brown, Dala Badreddine, Steven P Roose, Bret Rutherford, Hilsa N Ayonayon, Kristine Yaffe, Eleanor M Simonsick, Bret Goodpaster
OBJECTIVE: Fatigability is the degree to which performance decreases during a specific activity of a given intensity and duration. Depression is known to heighten subjective fatigue, but whether its association with physical fatigability is unknown. Further, whether fatigability is a precursor or risk factor for the development of subsequent depressive symptoms is also unclear. METHODS: Data are from the Health Aging and Body Composition Study with fatigability assessed using isokinetic dynamometry of the knee extensors at year 3, and depressive symptoms ascertained longitudinally using the Center for Epidemiologic Studies Depression (CES-D) scale...
February 15, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28195361/frailty-and-incident-depression-in-community-dwelling-older-people-results-from-the-elsa-study
#20
Nicola Veronese, Marco Solmi, Stefania Maggi, Marianna Noale, Giuseppe Sergi, Enzo Manzato, A Matthew Prina, Michele Fornaro, André F Carvalho, Brendon Stubbs
OBJECTIVE: Frailty and pre-frailty are two common conditions in the older people, but whether these conditions could predict depression is still limited to a few longitudinal studies. In this paper, we aimed to investigate whether frailty and pre-frailty are associated with an increased risk of depression in a prospective cohort of community-dwelling older people. METHODS: Four thousand seventy-seven community-dwelling men and women over 60 years without depression at baseline were included from the English Longitudinal Study of Ageing...
February 14, 2017: International Journal of Geriatric Psychiatry
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