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International Journal of Geriatric Psychiatry

Dylan J Jester, Kathryn Hyer, Victor Molinari, Ross Andel, Ellen Rozek
OBJECTIVES: To assess factors related to antipsychotic (AP) use in skilled nursing facilities for newly admitted residents aged 18 to 49, 50 to 64, 65 to 84, and 85 years or older. METHODS: Retrospective, population-level, Minimum Data Set (MDS) 2.0 data from the United States during the year of 2009 were used. Over 1 million residents were included. Fourteen clinically relevant variables were identified through a literature search. Antipsychotic use was defined as APs dispensed daily for the prior 7 days...
July 8, 2018: International Journal of Geriatric Psychiatry
Gregory J Tranah, Jeanne E Maglione, Kristine Yaffe, Shana M Katzman, Todd M Manini, Stephen Kritchevsky, Anne B Newman, Tamara B Harris, Steven R Cummings
OBJECTIVES: Mitochondrial DNA (mtDNA) heteroplasmy is a mixture of normal and mutated mtDNA molecules in a cell. High levels of heteroplasmy at several mtDNA sites in complex I lead to inherited neurological neurologic diseases and brain magnetic resonance imaging (MRI) abnormalities. Here, we test the hypothesis that mtDNA heteroplasmy at these complex I sites is associated with depressive symptoms in the elderly. METHODS: We examined platelet mtDNA heteroplasmy for associations with depressive symptoms among 137 participants over age 70 from the community-based Health, Aging and Body Composition Study...
July 8, 2018: International Journal of Geriatric Psychiatry
Yuting Zhang, Yaohua Gu, Yupeng Zhang, Xiangxiang Liu, Yanan Zhang, Wenwen Wu, Xuyu Chen, Qiru Wang, Xiaodong Tan
OBJECTIVE: We aimed to assess the effect of socioeconomic status and physical activity on cognitive function using a large population-based survey data in China. METHODS: We took advantage of the Chinese Longitudinal Healthy Longevity Survey conducted in 2014 to examine the relationship between sociodemographic, physical activity, and cognitive function in older adults (OAs) for persons aged above 65 (N = 2848). Socioeconomic status was assessed by sex, age, co-residence situation, category of residence, years of schooling, and marital status...
July 8, 2018: International Journal of Geriatric Psychiatry
Audun Osland Vik-Mo, Lasse Melvaer Giil, Clive Ballard, Dag Aarsland
OBJECTIVE: Neuropsychiatric symptoms (NPS) in dementia are frequent and challenging for patients, carers, and the health care system, but few long-term studies exist. We analyse the longitudinal course of NPS in patients with mild dementia. METHODS: A longitudinal cohort study of 223 patients with mild dementia and annual assessments using the Neuropsychiatric Inventory (NPI) for 5 years. RESULTS: A total 1043 NPI assessments, representing 97% of all possible measurements of living cohort members, were analysed...
July 6, 2018: International Journal of Geriatric Psychiatry
Tingting Sha, Yan Yan, Wenwei Cheng
OBJECTIVES: A prospective study was performed to examine the relationship of childhood socioeconomic status (SES) with cognition and the rate of change in a nationally representative sample of community-dwelling middle-aged and older Chinese population. METHODS: This study mainly focused on 3 composite measures of cognitive function, including Telephone Interview of Cognitive Status, word recall, and drawing a figure successfully. Childhood SES was evaluated by parental occupation and education, childhood residence, and self-evaluated financial status...
July 3, 2018: International Journal of Geriatric Psychiatry
Bannin De Witt Jansen, Kevin Brazil, Peter Passmore, Hilary Buchanan, Doreen Maxwell, Sonja McIlfatrick, Sharon M Morgan, Max Watson, Carole Parsons
BACKGROUND: Observational pain tools (OPTs) are widely recommended in health care policies, clinical guidelines, and recommendations for pain assessment and management. However, it is unclear whether and how these tools are used for patients with advanced dementia approaching the end of life. AIM: To explore hospice, secondary, and primary care physicians' and nurses' use of OPTs with patients dying with advanced dementia and their perspectives on practice development and training needs...
July 1, 2018: International Journal of Geriatric Psychiatry
Sarah Renouf, Dominic Ffytche, Rebecca Pinto, Joanna Murray, Vanessa Lawrence
OBJECTIVES: Visual hallucinations (VHs) can occur in several clinical conditions, of which the dementias, broadly defined, and Parkinson's disease rank among the most common. There is limited research on the lived experience of hallucinations among affected individuals and therefore a lack of evidence-based management strategies. This study used qualitative methods to explore the VH experience of individuals with dementia or Parkinson's disease and their informal caregivers. METHODS: In-depth interviews were conducted with 10 individuals with VHs and dementia and 11 informal caregivers, and 11 individuals with VHs and Parkinson's disease and 9 informal caregivers...
June 28, 2018: International Journal of Geriatric Psychiatry
Kazushige Ihara, Manabu Fuchikami, Masahiro Hashizume, Satoshi Okada, Hisashi Kawai, Shuichi Obuchi, Hirohiko Hirano, Yoshinori Fujiwara, Mitsugu Hachisu, Kim Hongyong, Shigeru Morinobu
OBJECTIVE: Brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of psychiatric disorders in adults and elderly individuals, and as a result, the DNA methylation (DNAm) of the BDNF gene in peripheral tissues including blood has been extensively examined to develop a useful biomarker for psychiatric disorders. However, studies to date have not previously investigated the effect of age on DNAm of the BDNF gene in blood. In this context, we measured DNAm of 39 CpG units in the CpG island at the promoter of exon I of the BDNF gene...
June 28, 2018: International Journal of Geriatric Psychiatry
Mitzi M Gonzales, Philip S Insel, Craig Nelson, Duygu Tosun, Michael Schöll, Niklas Mattsson, Simona Sacuiu, David Bickford, Michael W Weiner, R Scott Mackin
OBJECTIVES: To investigate the association between chronic subsyndromal symptoms of depression (SSD), cerebrospinal fluid (CSF) biomarkers, and neuropsychological performance in individuals with mild cognitive impairment (MCI). METHODS: Participants included 238 older adults diagnosed with MCI from the Alzheimer's Disease Neuroimaging Initiative repository with cognitive and CSF amyloid beta (Aβ1-42 ), total tau (t-tau), and phosphorylated tau (p-tau) data. The Neuropsychiatric Inventory identified individuals with chronic endorsement (SSD group N = 80) or no endorsement (non-SSD group N = 158) of depressive symptoms across timepoints...
June 28, 2018: International Journal of Geriatric Psychiatry
Abigail B Waters, Kayle S Sawyer, David A Gansler
INTRODUCTION: In middle age, declines in executive functioning (EF) are associated with decrements in the quality and/or quantity of white and grey matter. Recruitment of homologous regions has been identified as a compensatory mechanism for cognitive decline in later middle age; however, research into neural substrates of EF has yet to be guided by dedifferentiation models. We hypothesized that frontal-parietal grey matter volume, interhemispheric white matter, and intrahemispheric white matter fractional anisotropy will be predictive of EF...
June 27, 2018: International Journal of Geriatric Psychiatry
Carole Fogg, Peter Griffiths, Paul Meredith, Jackie Bridges
OBJECTIVES: To summarise existing knowledge of outcomes of older hospital patients with cognitive impairment, including the type and frequency of outcomes reported, and the additional risk experienced by this patient group. METHODS: Integrative literature review. Health care literature databases, reports, and policy documents on key websites were systematically searched. Papers describing the outcomes of older people with cognitive impairment during hospitalisation and at discharge were analysed and summarised using integrative methods...
June 26, 2018: International Journal of Geriatric Psychiatry
Amanda N Leggett, Amanda J Sonnega, Matthew C Lohman
OBJECTIVES: Insomnia and depressive symptoms are commonly reported by adults and have independently been found to be associated with mortality, though contrasting findings are reported. Given the high comorbidity and interrelatedness between these symptoms, we tested whether insomnia symptoms explain risk of death independent of depressive symptoms. We examined insomnia symptoms and depressive symptoms, in addition to other health and demographic covariates, as predictors of all-cause mortality...
June 25, 2018: International Journal of Geriatric Psychiatry
Saima Ahmed, Jane Hughes, Sue Davies, Karen Stewart, Martin Orrell, Paul Clarkson, David Challis
OBJECTIVES: This study investigated staff roles and tasks in Community Mental Health Teams (CMHT) and memory clinics, which are provided within a framework determined by local Clinical Commissioning Groups. METHODS: A cross-sectional survey design was used to collect data in England in 2015. Teams were identified by mental health providers (n = 68) and invited to complete a questionnaire. RESULTS: Fifty-one NHS Trusts responded to the request...
June 22, 2018: International Journal of Geriatric Psychiatry
Aisling A Jennings, Tony Foley, Kieran A Walsh, Alice Coffey, John P Browne, Colin P Bradley
OBJECTIVES: To synthesise the existing published literature on general practitioners (GP)'s knowledge, attitudes, and experiences of managing behavioural and psychological symptoms of dementia (BPSD) with a view to informing future interventions. METHODS: We conducted a systematic review and synthesis of quantitative and qualitative studies that explored GPs' experiences of managing BPSD (PROSPERO protocol registration CRD42017054916). Seven electronic databases were searched from inception to October 2017...
June 13, 2018: International Journal of Geriatric Psychiatry
José Alberto Avila-Funes, Alfonso Zamudio-Rodríguez, Luis Arnoldo Muñoz-Nevárez, Pablo Francisco Belaunzarán-Zamudio, Julio Alberto Díaz-Ramos, Juan Luis Alcala-Zermeno, Camille Ouvrard, Juan Sierra-Madero, Hélène Amieva
OBJECTIVE: To establish the correlates of depressive symptoms among Mexican community-dwelling older people living with HIV (PLWHIV). METHODS: Cross-sectional, 2-center study of 328 participants aged 50 or older being followed in the outpatient HIV clinics of 2 tertiary care hospitals in Mexico. Data were obtained through a comprehensive geriatric assessment. Multivariate logistic regression analyses were performed to identify the correlates of depressive symptoms...
June 13, 2018: International Journal of Geriatric Psychiatry
Takayo Nakabe, Noriko Sasaki, Hironori Uematsu, Susumu Kunisawa, Anders Wimo, Yuichi Imanaka
OBJECTIVE: We aimed to quantify the personal economic burden of dementia care in Japan according to residence type. METHODS: A cross-sectional online survey was conducted on 3841 caregivers of people with dementia. An opportunity cost approach was used to calculate informal care costs. All costs and the observed/expected (OE) ratio of costs were adjusted using patient sex, age, and care-needs levels, and compared among the residence types. RESULTS: The mean daily informal care time was 8...
June 12, 2018: International Journal of Geriatric Psychiatry
Maartje S Klapwijk, Monique A A Caljouw, Marjoleine J C Pieper, Hein Putter, Jenny T van der Steen, Wilco P Achterberg
OBJECTIVE: The objective of this study was to examine whether implementation of a stepwise multicomponent intervention (STA OP!) for challenging behavior and pain affects quality of life (QoL) of nursing home residents with moderate to severe dementia after 3 and 6 months. METHODS: A cluster randomized controlled trial was conducted in 12 nursing homes. Both control (n = 140) and intervention group (=148) received training, the intervention group was also treated using the STA OP! INTERVENTION: At baseline, 3 and 6 months QoL was assessed using the 6 QUALIDEM domains applicable to moderate and severe dementia...
June 11, 2018: International Journal of Geriatric Psychiatry
Antonios A Mougias, Foteini Christidi, Giorgos Kiosterakis, Lambros Messinis, Antonios Politis
No abstract text is available yet for this article.
June 1, 2018: International Journal of Geriatric Psychiatry
Zhixin Wang, Caiyun Ma, Hongjuan Han, Runlian He, Liye Zhou, Ruifeng Liang, Hongmei Yu
OBJECTIVES: Although there are many studies on the relationship between patient-related factors and negative caregiver outcomes, the specifics of this relationship are poorly understood. We aimed to examine whether caregiver social support moderated the relationship between patient factors and negative outcomes for caregivers of community-dwelling older adults with Alzheimer's disease (AD), and whether positive aspects of caregiving mediated this relationship. METHODS: We conducted a cross-sectional study of patients diagnosed with AD from 2 hospitals and 3 communities in Taiyuan, China, and their caregivers...
June 1, 2018: International Journal of Geriatric Psychiatry
Iracema Leroi, Kentaro Watanabe, Nick Hird, Taro Sugihara
BACKGROUND: The burgeoning field of gerontechnology, which is the interdisciplinary field of applying technology to ageing issues, has focused primarily on "active ageing" and maintaining independence for older adults. To date, there has been less focus on people who develop dementia. Here, we argue for the field of gerontechnology to have a greater emphasis on clinical applications for dementia. This can be captured under the rubric of "psychogeritechnology," a term we have coined to describe the range of technology approaches to the prevention, prediction, screening, assessment, diagnosis, management, and monitoring of people at risk of, or living with, dementia...
May 31, 2018: International Journal of Geriatric Psychiatry
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