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International Journal of Geriatric Psychiatry

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https://www.readbyqxmd.com/read/28643948/investigating-the-separate-and-interactive-associations-of-trauma-and-depression-on-brain-structure-implications-for-cognition-and-aging
#1
Aimee J Karstens, Olusola Ajilore, Leah H Rubin, Shaolin Yang, Aifeng Zhang, Alex Leow, Anand Kumar, Melissa Lamar
OBJECTIVE: Trauma and depression are associated with brain structural alterations; their combined effects on these outcomes are unclear. We previously reported a negative effect of trauma, independent of depression, on verbal learning and memory; less is known about underlying structural associates. We investigated separate and interactive associations of trauma and depression on brain structure. METHODS: Adults aged 30-89 (N = 203) evaluated for depression (D+) and trauma history (T+) using structured clinical interviews were divided into 53 D+T+, 42 D+T-, 50 D-T+, and 58 D-T-...
June 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28643900/exploring-perspectives-of-young-onset-dementia-caregivers-with-high-versus-low-unmet-needs
#2
Joany K Millenaar, Christian Bakker, Deliane van Vliet, Raymond T C M Koopmans, Alexander Kurz, Frans R J Verhey, Marjolein E de Vugt
BACKGROUND: This study is part of the Research to Assess Policies and Strategies for Dementia in the Young project. Information about specific needs in young onset dementia (YOD) will provide the basis for the development of an e-health intervention to assist caregivers in coping with YOD in several European countries. OBJECTIVE: The aim was to investigate the issues caregivers of people with YOD face. METHODS: A qualitative content analysis method was used to analyse interviews with YOD caregivers...
June 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28643852/therapeutic-d2-3-receptor-occupancies-and-response-with-low-amisulpride-blood-concentrations-in-very-late-onset-schizophrenia-like-psychosis-vloslp
#3
Suzanne Reeves, Kate Eggleston, Elizabeth Cort, Emma McLachlan, Stuart Brownings, Akshay Nair, Suki Greaves, Alan Smith, Joel Dunn, Paul Marsden, Robert Kessler, David Taylor, Julie Bertrand, Robert Howard
OBJECTIVE: Antipsychotic drug sensitivity in very late-onset schizophrenia-like psychosis (VLOSLP) is well documented, but poorly understood. This study aimed to investigate blood drug concentration, D2/3 receptor occupancy and outcome in VLOSLP during open amisulpride prescribing, and compare this with Alzheimer's disease (AD). METHODS: Blood drug concentration, prolactin, symptoms and extrapyramidal side-effects (EPS) were serially assessed during dose titration...
June 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28639724/longitudinal-changes-in-global-and-domain-specific-cognitive-function-in-the-very-old-findings-from-the-newcastle-85-study
#4
Blossom C M Stephan, Graciela Muniz-Terrera, Antoneta Granic, Joanna Collerton, Karen Davies, Brian K Saxby, Keith A Wesnes, Thomas B L Kirkwood, Carol Jagger
OBJECTIVE: Ageing is associated with changes in cognition in some, but not all domains. In young-old adults, defined as persons aged 65-84 years, baseline cognitive function has been shown to impact on cognitive trajectories. Whether similar patterns occur in the very-old, defined as persons aged 85 years and over, is not known. METHODS: Longitudinal changes (5 years' follow-up) in global and domain specific cognitive function including memory, attention and speed were investigated in participants from the Newcastle 85+ Study (n = 845)...
June 22, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28639714/plasma-cytokine-il-6-levels-and-subjective-cognitive-decline-preliminary-findings
#5
Andrew P Keegan, Daniel Paris, Cheryl A Luis, Laila Abdullah, Ghania Ait-Ghezala, David Beaulieu-Abdelahad, Makenzie Pryor, Jillian Chaykin, Gogce Crynen, Fiona Crawford, Michael Mullan
OBJECTIVE: Detection of Alzheimer's disease (AD) prior to clinical inception will be paramount for introducing disease modifying treatments. We have begun collecting baseline characteristics of a community cohort for longitudinal assessment and testing of antecedent blood-based biomarkers. We describe the baseline visit from the first 131 subjects in relationship to a commonly described cytokine, interleukin 6 (IL-6). METHODS: Subjects from the community presented for a free memory screening with varying degrees of memory concern...
June 22, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28639712/the-effect-of-childcare-activities-on-cognitive-status-and-depression-in-older-adults-gender-differences-in-a-4-4-year-longitudinal-study
#6
Caterina Trevisan, Maria Valentina Pamio, Chiara Curreri, Stefania Maggi, Giovannella Baggio, Sabina Zambon, Leonardo Sartori, Egle Perissinotto, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi
OBJECTIVES: Although involvement in childcare activities seems to promote better physical and mental health in older adults, its impact on cognitive status and depression has not yet been fully elucidated. We aimed to analyze the association between engagement in childcare activities and cognitive and psychological status over a 4.4-year period in community-dwelling older adults. METHODS: Two thousand one hundred four subjects older than 65 years without severe cognitive impairment at baseline were categorized according to the frequency of their involvement in childcare activities (everyday, occasionally, never)...
June 22, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28639286/provision-and-perceived-quality-of-mental-health-services-for-older-care-home-residents-in-england-a-national-survey
#7
Karen Stewart, Claire Hargreaves, Rowan Jasper, David Challis, Sue Tucker, Mark Wilberforce
OBJECTIVE: This study examined the nature, extent and perceived quality of the support provided by community mental health teams for older people (CMHTsOP) to care home residents. METHODS: A postal survey was sent to all CMHTsOP in England. Information was collected about teams' staffing and their involvement in case finding, assessment, medication reviews, care planning and training as well as team managers' rating of the perceived quality of the service they provided for care home residents...
June 22, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28627719/the-frontal-assessment-battery-in-clinical-practice-a-systematic-review
#8
REVIEW
Miriam Hurtado-Pomares, M Carmen Terol-Cantero, Alicia Sánchez-Pérez, Paula Peral-Gómez, Desirée Valera-Gran, Eva María Navarrete-Muñoz
BACKGROUND: The frontal assessment battery (FAB) is a brief tool designed to evaluate executive function. Some studies have particularly focused on assessing its applicability addressing two issues: first, on detecting the brain regions responsible for the FAB performance, and second, on determining its capability for differential diagnosis. Our aim was to summarize and analyze critically the studies that assessed the neuroanatomical correspondence and the differential diagnostic value of the FAB in several study populations suffering from different pathologies...
June 19, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28612928/the-cost-effectiveness-implications-of-suboptimal-treatment-for-different-severities-of-alzheimer-s-disease-in-the-uk
#9
Darshan Zala, Dennis Chan, Paul McCrone
OBJECTIVE: This study aims to evaluate the impact of suboptimal treatment, defined in terms of lower population coverage (percentage of total patient population receiving optimal treatment) and delay to treatment on the cost-effectiveness of pharmacological therapies approved for the treatment of different severities of Alzheimer's disease (AD) in the UK. METHODS: A 5-year Markov model was used to simulate transition to full-time care, as delay and coverage were varied for AD patients with mild-to-moderate and moderate-to-severe dementia...
June 14, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28612377/apolipoprotein-e-genotype-impact-on-memory-and-attention-in-older-persons-the-moderating-role-of-personality-phenotype
#10
Benjamin P Chapman, Ralph H B Benedict, Feng Lin, Shumita Roy, Antoine Porteinsson, Kinga Szigeti, Howard Federoff, Mark Mapstone
OBJECTIVES: To determine if phenotypic personality traits modify the association of Apolipoprotein E (APOE) genotypes with different domains of cognitive function. DESIGN: Cross-sectional. METHODS: 172 non-demented older adults were administered the NEO-Five Factor Inventory (NEO-FFI), a battery of neuropsychological tests assessing memory, attention, executive function, language, and visuospatial ability, and underwent APOE genotyping. Multivariate (multiple-dependent variable) regression models predicting cognitive domains tested APOE interactions with personality traits, adjusting for age, sex, and education...
June 14, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28612359/the-relationship-between-moderate-alcohol-consumption-depressive-symptomatology-and-c-reactive-protein-the-health-and-retirement-study
#11
Daniel Paulson, Mona Shah, Danielle Herring, Rosanna Scott, Manuel Herrera, David Brush, Rachel Bassett
OBJECTIVE: Moderate alcohol use has been broadly associated with health benefits among older adults, including improved mood. Aims of this study were to evaluate the relationship of moderate alcohol use and depressive symptomatology over a period of eight years, and to examine inflammation, indicated by C-reactive protein (CRP), as one mechanism by which this relationship functions. METHODS: The study included 3177 community-dwelling participants over the age of 65 in 2008 drawn from the Health and Retirement Study...
June 14, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28585721/-let-him-speak-a-descriptive-qualitative-study-of-the-roles-and-behaviors-of-family-companions-in-primary-care-visits-among-older-adults-with-cognitive-impairment
#12
Judith B Vick, Halima Amjad, Katherine C Smith, Cynthia M Boyd, Laura N Gitlin, David L Roth, Debra L Roter, Jennifer L Wolff
OBJECTIVE: Cognitive impairment poses communication challenges in primary care. Although family "companions" commonly attend primary care visits of older adults with cognitive impairment, little is known about how their involvement affects communication. Therefore, we sought to understand how companion involvement affects the quality of primary care visit communication for older adults with cognitive impairment. METHODS: Cross-sectional, descriptive qualitative study participants were as follows: (1) English-speaking adults age 65 or older with mild, moderate, or severe cognitive impairment; (2) family members or other unpaid companions who accompany older adults to primary care visits; and (3) primary care clinicians...
June 6, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28585694/the-abrams-geriatric-self-neglect-scale-introduction-validation-and-psychometric-properties
#13
Robert C Abrams, M Carrington Reid, Cynthia Lien, Maria Pavlou, Anthony Rosen, Nancy Needell, Joseph Eimicke, Jeanne Teresi
OBJECTIVE: Self-neglect is an imprecisely defined entity with multiple clinical expressions and adverse health consequences, especially in the elderly. However, research has been limited by the absence of a measurement instrument that is both inclusive and specific. Our goal was to establish the psychometric properties of a quantitative instrument, the Abrams Geriatric Self-Neglect Scale (AGSS). METHODS: We analyzed data from a 2007 case-control study of 71 cognitively intact community-dwelling older self-neglectors that had used the AGSS...
June 6, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28585290/csf-biomarkers-in-delirium-a-systematic-review
#14
Roanna J Hall, Leiv Otto Watne, Emma Cunningham, Henrik Zetterberg, Susan D Shenkin, Torgeir Bruun Wyller, Alasdair M J MacLullich
OBJECTIVE: In recent years, there has been a blossoming of studies examining cerebrospinal fluid (CSF) as a method of studying the pathophysiology of delirium. We systematically reviewed the literature for CSF studies in delirium and provide here a summary of the implications for our understanding of delirium pathophysiology. We also summarise the methods used for CSF analysis and discuss challenges and implications for future studies. METHODS: In this systematic review, we screened MEDLINE, EMBASE, PsycINFO, Web of Science, PubMed and the Cochrane Library for articles on CSF biomarkers in delirium, published on 3 September 2016...
June 6, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28574155/a-systematic-review-of-neuroimaging-in-delirium-predictors-correlates-and-consequences
#15
Anita Nitchingham, Varun Kumar, Susan Shenkin, Karen J Ferguson, Gideon A Caplan
OBJECTIVE: Neuroimaging advances our understanding of delirium pathophysiology and its consequences. A previous systematic review identified 12 studies (total participants N = 764, delirium cases N = 194; years 1989-2007) and found associations with white matter hyperintensities (WMH) and cerebral atrophy. Our objectives were to perform an updated systematic review of neuroimaging studies in delirium published since January 2006 and summarise the available literature on predictors, correlates or outcomes...
June 2, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28560807/psychometric-evaluation-of-the-cohen-mansfield-agitation-inventory-in-an-acute-general-hospital-setting
#16
Nuriye Kupeli, Victoria Vickerstaff, Nicola White, Kathryn Lord, Sharon Scott, Louise Jones, Elizabeth L Sampson
OBJECTIVES: The Cohen-Mansfield Agitation Inventory (CMAI; (Cohen-Mansfield and Kerin, 1986)) is a well-known tool for assessing agitated behaviours in people with dementia who reside in long-term care. No studies have evaluated the psychometric qualities and factor structure of the CMAI in acute general hospitals, a setting where people with demand may become agitated. METHOD: Longitudinal study investigating pain, agitation and behavioural problems in 230 people with dementia admitted to acute general hospitals in 2011-2012...
May 31, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28560728/decreasing-hazards-of-alzheimer-s-disease-with-the-use-of-antidepressants-mitigating-the-risk-of-depression-and-apolipoprotein-e
#17
Shanna L Burke, Peter Maramaldi, Tamara Cadet, Walter Kukull
OBJECTIVE: Alzheimer's disease (AD) is a neurodegenerative disease, manifesting in clinically observable deficits in memory, thinking, and behavior that disproportionately affects older adults. Susceptibility genes, such as apolipoprotein ε4, have long been associated with an increased risk of AD diagnosis. Studies have shown associations between depression and increased risk of AD development. Furthermore, findings from previous investigations suggest mixed effects in the use of psychotropic medication in older adults...
May 31, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28556415/symptoms-associated-with-lewy-body-disease-in-mild-cognitive-impairment
#18
Paul C Donaghy, Nicola Barnett, Kirsty Olsen, John-Paul Taylor, Ian G McKeith, John T O'Brien, Alan J Thomas
OBJECTIVE: Dementia with Lewy bodies (DLB) is associated with a range of cognitive and non-cognitive symptoms. We aimed to identify if some of these symptoms might aid early diagnosis of Lewy body disease in cases of mild cognitive impairment (MCI). METHODS: Lewy body MCI (MCI-LB; n = 36), Alzheimer's disease MCI (MCI-AD; n = 21), DLB (n = 36), AD (n = 21) and control (n = 20) participants were recruited. An interview-based questionnaire about the presence of symptoms thought to be associated with Lewy body disease was completed by participants with, where possible, their carer/relative...
May 29, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28556389/current-practice-and-challenges-in-night-time-care-for-people-with-dementia-living-in-care-homes-a-qualitative-study
#19
Kayleigh Marie Nunez, Zunera Khan, Ingelin Testad, Vanessa Lawrence, Byron Creese, Anne Corbett
OBJECTIVE: To explore the current practices and challenges in night-time care for people with dementia living in care homes in the UK. METHODS: Focus group discussions (FGD) were held with care staff and family carers from five care homes in South London. To supplement the FGD data, an online survey was circulated to family carers (n = 16), and informal interviews were conducted with night-time care staff and nurses (n = 19). The questions for the online survey were designed to specifically explore the themes that emerged from the FGD...
May 26, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28556262/the-test-of-time-a-history-of-clock-drawing
#20
REVIEW
Elias Hazan, Frances Frankenburg, Megan Brenkel, Kenneth Shulman
OBJECTIVE: The clock drawing test (CDT) has become one of the most widely used cognitive screening instruments in clinical and research settings. Its effectiveness, acceptability, and quick and easy administration have made it a staple for cognitive screening in dementia and a wide range of brain disorders. Despite a spike in popularity since the 1990s, its origins are relatively unknown. The goal of this review is to chronicle its saga and chart its usage over time. METHODS: PsycInfo, Medline, and PubMed literature searches were performed from earliest record to June 2016, in addition to manual cross-referencing of bibliographies, with a focus before 1990...
May 26, 2017: International Journal of Geriatric Psychiatry
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