journal
MENU ▼
Read by QxMD icon Read
search

Advanced Drug Delivery Reviews

journal
https://www.readbyqxmd.com/read/28214553/mimicking-oxygen-delivery-and-waste-removal-functions-of-blood
#1
Huaifa Zhang, Jake E Barralet
In addition to immunological and wound healing cell and platelet delivery, ion stasis and nutrient supply, blood delivers oxygen to cells and tissues and removes metabolic wastes. For decades researchers have been trying to develop approaches that mimic these two immediately vital functions of blood. Oxygen is crucial for the long-term survival of tissues and cells in vertebrates. Hypoxia (oxygen deficiency) and even at times anoxia (absence of oxygen) can occur during organ preservation, organ and cell transplantation, wound healing, in tumors and engineering of tissues...
February 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28163106/angiogenesis-regulation-by-nanocarriers-bearing-rna-interference
#2
REVIEW
Paula Ofek, Galia Tiram, Ronit Satchi-Fainaro
Since the approval of bevacizumab as anti-angiogenic therapy in 2004 by the FDA, an array of angiogenesis inhibitors have been developed and approved. However, results were disappointing with regard to their therapeutic efficacy. RNA interference approaches offer the possibility of rational design with high specificity, lacking in many current drug treatments for various diseases including cancer. However, in vivo delivery issues still represent a significant obstacle for widespread clinical applications. In the current review, we summarize the advances in the last decade in the field of angiogenesis-targeted RNA interference approaches, with special emphasis on oncology applications...
February 2, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28159606/recent-coating-developments-for-combination-devices-in-orthopedic-and-dental-applications-a-literature-review
#3
Eric J Tobin
Orthopedic and dental implants have been used successfully for decades to replace or repair missing or damaged bones, joints, and teeth, thereby restoring patient function subsequent to disease or injury. However, although device success rates are generally high, patient outcomes are sometimes compromised due to device-related problems such as insufficient integration, local tissue inflammation, and infection. Many different types of surface coatings have been developed to address these shortcomings, including those that incorporate therapeutic agents to provide localized delivery to the surgical site...
January 31, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28153578/improving-drug-like-properties-of-insulin-and-glp-1-via-molecule-design-and-formulation-and-improving-diabetes-management-with-device-drug-delivery
#4
REVIEW
Sergei Pechenov, Himanshu Bhattacharjee, Daniel Yin, Sachin Mittal, Anand Subramony
There is an increased incidence of diabetes worldwide. The discovery of insulin revolutionized the management of diabetes, the revelation of glucagon-like peptide -1 (GLP-1) and introduction of GLP-1 mimetics to clinical practice was another breakthrough. Continued translational research resulted in better understanding of diabetes, which, in combination with cutting-edge biology, chemistry, and pharmaceutical tools, have allowed for the development of safer, more effective and convenient insulins and GLP-1s...
January 30, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28111348/xenobiotic-transporters-and-kidney-injury
#5
REVIEW
Blessy George, Dahea You, Melanie S Joy, Lauren M Aleksunes
Renal proximal tubules are targets for toxicity due in part to the expression of transporters that mediate the secretion and reabsorption of xenobiotics. Alterations in transporter expression and/or function can enhance the accumulation of toxicants and sensitize the kidneys to injury. This can be observed when xenobiotic uptake by carrier proteins is increased or efflux of toxicants and their metabolites is reduced. Nephrotoxic chemicals include environmental contaminants (halogenated hydrocarbon solvents, the herbicide paraquat, the fungal toxin ochratoxin, and heavy metals) as well as pharmaceuticals (certain beta-lactam antibiotics, antiviral drugs, and chemotherapeutic drugs)...
January 20, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28088344/design-control-considerations-for-biologic-device-combination-products
#6
Dave Anderson, Roger Liu, J Anand Subramony, Jon Cammack
Combination products are therapeutic and diagnostic medical products that combine drugs, devices, and/or biological products with one another. Historically, biologics development involved identifying efficacious doses administered to patients intravenously or perhaps by a syringe. Until fairly recently, there has been limited focus on developing an accompanying medical device, such as a prefilled syringe or auto-injector, to enable easy and more efficient delivery. For the last several years, and looking forward, where there may be little to distinguish biologics medicines with relatively similar efficacy profiles, the biotechnology market is beginning to differentiate products by patient-focused, biologic-device based combination products...
January 11, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28065863/molecular-links-among-non-biodegradable-nanoparticles-reactive-oxygen-species-and-autophagy
#7
Uche C Anozie, Paul Dalhaimer
For nanoparticles to be successful in combating diseases in the clinic in the 21st century and beyond, they must localize to target areas of the body and avoid damaging non-target, healthy tissues. Both soft and stiff, bio-degradable and non-biodegradable nanoparticles are anticipated to be used to this end. It has been shown that stiff, non-biodegradable nanoparticles cause reactive oxygen species (ROS) generation and autophagy in a variety of cell lines in vitro. Both responses can lead to significant remodeling of the cytosol and even apoptosis...
January 5, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28042080/heparin-coatings-for-improving-blood-compatibility-of-medical-devices
#8
REVIEW
Roy Biran, Daniel Pond
Blood contact with biomaterials triggers activation of multiple reactive mechanisms that can impair the performance of implantable medical devices and potentially cause serious adverse clinical events. This includes thrombosis and thromboembolic complications due to activation of platelets and the coagulation cascade, activation of the complement system, and inflammation. Numerous surface coatings have been developed to improve blood compatibility of biomaterials. For more than thirty years, the anticoagulant drug heparin has been employed as a covalently immobilized surface coating on a variety of medical devices...
December 29, 2016: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/27940141/recent-progress-of-structural-study-of-polymorphic-pharmaceutical-drugs
#9
REVIEW
Kenjirou Higashi, Keisuke Ueda, Kunikazu Moribe
This review considers advances in the understanding of active pharmaceutical ingredient polymorphism since around 2010 mainly from a structural view point, with a focus on twelve model drugs. New polymorphs of most of these drugs have been identified despite that the polymorphism of these old drugs has been extensively studied so far. In addition to the conventional modifications of preparative solvents, temperatures, and pressure, more strategic structure-based methods have successfully yielded new polymorphs...
December 7, 2016: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/27916504/the-state-of-play-and-future-of-antibody-therapeutics
#10
REVIEW
Zehra Elgundi, Mouhamad Reslan, Esteban Cruz, Vicki Sifniotis, Veysel Kayser
It has been over four decades since the development of monoclonal antibodies (mAbs) using a hybridoma cell line was first reported. Since then more than thirty therapeutic antibodies have been marketed, mostly as oncology, autoimmune and inflammatory therapeutics. While antibodies are very efficient, their cost-effectiveness has always been discussed owing to their high costs, accumulating to more than one billion dollars from preclinical development through to market approval. Because of this, therapeutic antibodies are inaccessible to some patients in both developed and developing countries...
December 2, 2016: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/27913120/gene-delivery-nanoparticles-to-modulate-angiogenesis
#11
REVIEW
Jayoung Kim, Adam C Mirando, Aleksander S Popel, Jordan J Green
Angiogenesis is naturally balanced by many pro- and anti-angiogenic factors while an imbalance of these factors leads to aberrant angiogenesis, which is closely associated with many diseases. Gene therapy has become a promising strategy for the treatment of such a disordered state through the introduction of exogenous nucleic acids that express or silence the target agents, thereby engineering neovascularization in both directions. Numerous non-viral gene delivery nanoparticles have been investigated towards this goal, but their clinical translation has been hampered by issues associated with safety, delivery efficiency, and therapeutic effect...
November 30, 2016: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28189183/radiotherapy-for-cancer-present-and-future
#12
EDITORIAL
Christine Allen, Sohyoung Her, David A Jaffray
No abstract text is available yet for this article.
January 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/27932046/stereotactic-ablative-body-radiosurgery-sabr-or-stereotactic-body-radiation-therapy-sbrt
#13
REVIEW
Michael R Folkert, Robert D Timmerman
While conventional treatment relies on protracted courses of therapy using relatively small dose-per-fraction sizes of 1.8-2Gy, there is substantial evidence gathered over decades that this may not be the optimal approach for all targetable disease. Stereotactic ablative body radiosurgery (SABR) or stereotactic body radiation therapy (SBRT) is a technique which uses precise targeting to deliver high doses of radiation capable of ablating tumors directly. In this review, we will discuss the justification for and techniques used to deliver ablative doses to improve treatment outcomes, interactions with biological and immunologic therapy, and special procedures to spare normal tissue, which have facilitated the expanding role for these techniques in the management of a wide range of malignant histologies and disease states...
January 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/27919760/proton-therapy-present-and-future
#14
REVIEW
Radhe Mohan, David Grosshans
In principle, proton therapy offers a substantial clinical advantage over conventional photon therapy. This is because of the unique depth-dose characteristics of protons, which can be exploited to achieve significant reductions in normal tissue doses proximal and distal to the target volume. These may, in turn, allow escalation of tumor doses and greater sparing of normal tissues, thus potentially improving local control and survival while at the same time reducing toxicity and improving quality of life. Protons, accelerated to therapeutic energies ranging from 70 to 250MeV, typically with a cyclotron or a synchrotron, are transported to the treatment room where they enter the treatment head mounted on a rotating gantry...
January 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/27771366/molecular-targeting-of-hypoxia-in-radiotherapy
#15
REVIEW
Sergio Rey, Luana Schito, Marianne Koritzinsky, Bradly G Wouters
Hypoxia (low O2) is an essential microenvironmental driver of phenotypic diversity in human solid cancers. Hypoxic cancer cells hijack evolutionarily conserved, O2- sensitive pathways eliciting molecular adaptations that impact responses to radiotherapy, tumor recurrence and patient survival. In this review, we summarize the radiobiological, genetic, epigenetic and metabolic mechanisms orchestrating oncogenic responses to hypoxia. In addition, we outline emerging hypoxia- targeting strategies that hold promise for individualized cancer therapy in the context of radiotherapy and drug delivery...
January 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/27637454/advancements-in-brachytherapy
#16
REVIEW
Kari Tanderup, Cynthia Ménard, Csaba Polgar, Jacob Christian Lindegaard, Christian Kirisits, Richard Pötter
Brachytherapy is a radiotherapy modality associated with a highly focal dose distribution. Brachytherapy treats the cancer tissue from the inside, and the radiation does not travel through healthy tissue to reach the target as with external beam radiotherapy techniques. The nature of brachytherapy makes it attractive for boosting limited size target volumes to very high doses while sparing normal tissues. Significant developments over the last decades have increased the use of 3D image guided procedures with the utilization of CT, MRI, US and PET...
January 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/27262923/radiation-effects-on-the-tumor-microenvironment-implications-for-nanomedicine-delivery
#17
REVIEW
Shawn Stapleton, David Jaffray, Michael Milosevic
The tumor microenvironment has an important influence on cancer biological and clinical behavior and radiation treatment (RT) response. However, RT also influences the tumor microenvironment in a complex and dynamic manner that can either reinforce or inhibit this response and the likelihood of long-term disease control in patients. It is increasingly evident that the interplay between RT and the tumor microenvironment can be exploited to enhance the accumulation and intra-tumoral distribution of nanoparticles, mediated by changes to the vasculature and stroma with secondary effects on hypoxia, interstitial fluid pressure (IFP), solid tissue pressure (STP), and the recruitment and activation of bone marrow-derived myeloid cells (BMDCs)...
January 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/26877102/cancer-stem-cells-radioresistance-prediction-of-radiotherapy-outcome-and-specific-targets-for-combined-treatments
#18
REVIEW
Mechthild Krause, Anna Dubrovska, Annett Linge, Michael Baumann
Inactivation of cancer stem cells (CSCs) is of utmost importance for tumor cure after radiotherapy. An increasing body of evidence complies with a higher radioresistance of CSCs compared to the mass of tumor cells, supporting the use of CSC related biomarkers for prediction of radiotherapy outcome. Treatment individualization strategies for patient groups with vastly different risk of recurrence will most likely require application of more than one biomarker. Specifically, inclusion of established biomarkers like tumor size for primary radio(chemo)therapy or human papilloma virus (HPV) infection status in head and neck squamous cell carcinoma seems to be of very high relevance...
January 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/26774327/decision-support-systems-for-personalized-and-participative-radiation-oncology
#19
REVIEW
Philippe Lambin, Jaap Zindler, Ben G L Vanneste, Lien Van De Voorde, Daniëlle Eekers, Inge Compter, Kranthi Marella Panth, Jurgen Peerlings, Ruben T H M Larue, Timo M Deist, Arthur Jochems, Tim Lustberg, Johan van Soest, Evelyn E C de Jong, Aniek J G Even, Bart Reymen, Nicolle Rekers, Marike van Gisbergen, Erik Roelofs, Sara Carvalho, Ralph T H Leijenaar, Catharina M L Zegers, Maria Jacobs, Janita van Timmeren, Patricia Brouwers, Jonathan A Lal, Ludwig Dubois, Ala Yaromina, Evert Jan Van Limbergen, Maaike Berbee, Wouter van Elmpt, Cary Oberije, Bram Ramaekers, Andre Dekker, Liesbeth J Boersma, Frank Hoebers, Kim M Smits, Adriana J Berlanga, Sean Walsh
A paradigm shift from current population based medicine to personalized and participative medicine is underway. This transition is being supported by the development of clinical decision support systems based on prediction models of treatment outcome. In radiation oncology, these models 'learn' using advanced and innovative information technologies (ideally in a distributed fashion - please watch the animation: http://youtu.be/ZDJFOxpwqEA) from all available/appropriate medical data (clinical, treatment, imaging, biological/genetic, etc...
January 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/26712711/gold-nanoparticles-for-applications-in-cancer-radiotherapy-mechanisms-and-recent-advancements
#20
REVIEW
Sohyoung Her, David A Jaffray, Christine Allen
Gold nanoparticles (AuNPs) have emerged as novel radiosensitizers owing to their high X-ray absorption, synthetic versatility, and unique chemical, electronic and optical properties. Multi-disciplinary research performed over the past decade has demonstrated the potential of AuNP-based radiosensitizers, and identified possible mechanisms underlying the observed radiation enhancement effects of AuNPs. Despite promising findings from pre-clinical studies, the benefits of AuNP radiosensitization have yet to successfully translate into clinical practice...
January 15, 2017: Advanced Drug Delivery Reviews
journal
journal
29648
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"