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Advanced Drug Delivery Reviews

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https://www.readbyqxmd.com/read/28532691/bio-synthetic-materials-for-immunomodulation-of-islet-transplants
#1
Greg A Foster, Andrés J García
Clinical islet transplantation is an effective therapy in restoring physiological glycemic control in type 1 diabetics. However, allogeneic islets derived from cadaveric sources elicit immune responses that result in acute and chronic islet destruction. To prevent immune destruction of islets, transplant recipients require lifelong delivery of immunosuppressive drugs, which are associated with debilitating side effects. Biomaterial-based strategies to eliminate the need for immunosuppressive drugs are an emerging therapy for improving islet transplantation...
May 19, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28532690/combinatorial-drug-delivery-approaches-for-immunomodulation
#2
Joshua M Stewart, Benjamin G Keselowsky
Immunotherapy has been widely explored for applications to both augment or suppress intrinsic host immunity. Clinical achievements have seen a number of immunotherapeutic drugs displace established strategies like chemotherapy in treating immune-associated diseases. However, single drug approaches modulating an individual arm of the immune system are often incompletely effective. Imperfect mechanistic understanding and heterogeneity within disease pathology have seen monotherapies inadequately equipped to mediate complete disease remission...
May 19, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28526591/macrophage-based-therapeutic-strategies-in-regenerative-medicine
#3
Kara L Spiller, Timothy J Koh
Mounting evidence suggests that therapeutic cell and drug delivery strategies designed to actively harness the regenerative potential of the inflammatory response have great potential in regenerative medicine. In particular, macrophages have emerged as a primary target because of their critical roles in regulating multiple phases of tissue repair through their unique ability to rapidly shift phenotypes. Herein, we review macrophage-based therapies, focusing on the translational potential for cell delivery of ex vivo-activated macrophages and delivery of molecules and biomaterials to modulate accumulation and phenotype of endogenous macrophages...
May 16, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28506745/applying-nanomedicine-in-maladaptive-inflammation-and-angiogenesis
#4
Amr Alaarg, Carlos Pérez-Medina, Josbert M Metselaar, Matthias Nahrendorf, Zahi A Fayad, Gert Storm, Willem J M Mulder
Inflammation and angiogenesis drive the development and progression of multiple devastating diseases such as atherosclerosis, cancer, rheumatoid arthritis, and inflammatory bowel disease. Though these diseases have very different phenotypic consequences, they possess several common pathophysiological features in which monocyte recruitment, macrophage polarization, and enhanced vascular permeability play critical roles. Thus, developing rational targeting strategies tailored to the different stages of the journey of monocytes, from bone marrow to local lesions, and their extravasation from the vasculature in diseased tissues will advance nanomedicine...
May 12, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28506744/hepatic-stellate-cells-as-key-target-in-liver-fibrosis
#5
Takaaki Higashi, Scott L Friedman, Yujin Hoshida
Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more than one million deaths annually via development of cirrhosis, although no antifibrotic therapy has been approved to date. Transdifferentiation (or "activation") of hepatic stellate cells is the major cellular source of matrix protein-secreting myofibroblasts, the major driver of liver fibrogenesis. Paracrine signals from injured epithelial cells, fibrotic tissue microenvironment, immune and systemic metabolic dysregulation, enteric dysbiosis, and hepatitis viral products can directly or indirectly induce stellate cell activation...
May 12, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28506743/peptide-modified-nanomedicines-for-targeting-cells-at-the-tumor-microenvironment
#6
Ayelet David
Since their initial discovery more than 30 years ago, tumor-homing peptides have become an increasingly useful tool for targeted delivery of therapeutic and diagnostic agents into tumors. Today, it is well accepted that cells at tumor microenvironment (TME) contributes in many ways to cancer development and progression. Tumor-homing peptide are highly suitable ligands to actively target cells at the TME owing to their small size, low immunogenicity, stability, easy manufacturing and low cost. When conjugated to nanosized medicines (nanomedicines) these ligands can interact specifically with surface receptors expressed on cells in the heterogeneous TME, improve cellular uptake of nanomedicines by target cells, and potentially impair tumor growth and progression...
May 12, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28502767/modulating-angiogenesis-with-integrin-targeted-nanomedicines
#7
Aroa Duro-Castano, Elena Gallon, Caitlin Decker, María J Vicent
Targeting angiogenesis-related pathologies, which include tumorigenesis and metastatic processes, has become an attractive strategy for the development of efficient guided nanomedicines. In this respect, integrins are cell-adhesion molecules involved in angiogenesis signaling pathways and are overexpressed in many angiogenic processes. Therefore, they represent specific biomarkers not only to monitor disease progression but also to rationally design targeted nanomedicines. Arginine-glycine-aspartic (RGD) containing peptides that bind to specific integrins have been widely utilized to provide ligand-mediated targeting capabilities to small molecules, peptides, proteins, and antibodies, as well as to drug/imaging agent-containing nanomedicines, with the final aim of maximizing their therapeutic index...
May 12, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28502768/lysosomal-enzyme-replacement-therapies-historical-development-clinical-outcomes-and-future-perspectives
#8
Melani Solomon, Silvia Muro
Lysosomes and lysosomal enzymes play a central role in numerous cellular processes, including cellular nutrition, recycling, signaling, defense, and cell death. Genetic deficiencies of lysosomal components, most commonly enzymes, are known as "lysosomal storage disorders" or "lysosomal diseases" (LDs) and lead to lysosomal dysfunction. LDs broadly affect peripheral organs and the central nervous system (CNS), debilitating patients and frequently causing fatality. Among other approaches, enzyme replacement therapy (ERT) has advanced to the clinic and represents a beneficial strategy for 8 out of the 50-60 known LDs...
May 11, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28501510/surface-engineering-for-lymphocyte-programming
#9
Elana Ben-Akiva, Randall A Meyer, David R Wilson, Jordan J Green
The once nascent field of immunoengineering has recently blossomed to include approaches to deliver and present biomolecules to program diverse populations of lymphocytes to fight disease. Building upon improved understanding of the molecular and physical mechanics of lymphocyte activation, varied strategies for engineering surfaces to activate and deactivate T-Cells, B-Cells and natural killer cells are in preclinical and clinical development. Surfaces have been engineered at the molecular level in terms of the presence of specific biological factors, their arrangement on a surface, and their diffusivity to elicit specific lymphocyte fates...
May 10, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28501509/designer-outer-membrane-vesicles-as-immunomodulatory-systems-reprogramming-bacteria-for-vaccine-delivery
#10
Yehou M D Gnopo, Hannah C Watkins, Taylor C Stevenson, Matthew P DeLisa, David Putnam
Vaccines often require adjuvants to be effective. Traditional adjuvants, like alum, activate the immune response but in an uncontrolled way. Newer adjuvants help to direct the immune response in a more coordinated fashion. Here, we review the opportunity to use the outer membrane vesicles (OMVs) of bacteria as a way to modulate the immune response toward making more effective vaccines. This review outlines the different types of OMVs that have been investigated for vaccine delivery and how they are produced...
May 10, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28478084/screening-for-new-pharmaceutical-solid-forms-using-mechanochemistry-a-practical-guide
#11
REVIEW
Dritan Hasa, William Jones
Within the pharmaceutical industry, and elsewhere, the screening for new solid forms is a mandatory exercise for both existing and new chemical entities. This contribution focuses on mechanochemistry as a versatile approach for discovering new and alternative solid forms. Whilst a series of recently published extensive reviews exist which focus on mechanistic aspects and potential areas of development, in this review we focus on particular practical aspects of mechanochemistry in order to allow full optimisation of the approach in searches for new solid forms including polymorphs, salts and cocrystals as well as their solvated/hydrated analogues...
May 3, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28457884/substrate-mediated-enzyme-prodrug-therapy
#12
REVIEW
Betina Fejerskov, Morten T Jarlstad Olesen, Alexander N Zelikin
Substrate mediated enzyme prodrug therapy (SMEPT) is a biomedical platform developed to perform a localized synthesis of drugs mediated by implantable biomaterials. This approach combines the benefits and at the same time offers to overcome the drawbacks for traditional pill-based drug administration and site-specific, implant mediated drug delivery. Specifically, SMEPT offers the flexibility of delivering multiple drugs - individually as monotherapy, in sequence, or as a combination therapy, all of which is also accomplished in a site-specific manner...
April 27, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28455189/biomaterial-strategies-for-generating-therapeutic-immune-responses
#13
REVIEW
Sean H Kelly, Lucas S Shores, Nicole L Votaw, Joel H Collier
Biomaterials employed to raise therapeutic immune responses have become a complex and active field. Historically, vaccines have been developed primarily to fight infectious diseases, but recent years have seen the development of immunologically active biomaterials towards an expanding list of non-infectious diseases and conditions including inflammation, autoimmunity, wounds, cancer, and others. This review structures its discussion of these approaches around a progression from single-target strategies to those that engage increasingly complex and multifactorial immune responses...
April 25, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28455188/near-infrared-light-activatable-polymeric-nanoformulations-for-combined-therapy-and-imaging-of-cancer
#14
REVIEW
Xiuli Yue, Qiang Zhang, Zhifei Dai
Near infrared (NIR) light allows deep tissue penetration and high spatial resolution due to the reduced scattering of long-wavelength photons. NIR light-activatable polymer nanoparticles are widely exploited for enhanced cancer imaging (diagnosis) and therapy owing to their superior photostability, photothermal conversion efficiency (or high emission rate), and minimal toxicity to cells and tissues. This review surveys the most recent advances in the synthesis of different NIR-absorbing and emissive polymer nanoformulations, and their applications for cancer imaging, photothermal therapy, theranostics and combination therapy by delivering multiple small molecule chemotherapeutics...
April 25, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28455187/progress-and-opportunities-for-enhancing-the-delivery-and-efficacy-of-checkpoint-inhibitors-for-cancer-immunotherapy
#15
REVIEW
David M Francis, Susan N Thomas
Despite the advent of immune checkpoint blockade for effective treatment of advanced malignancies, only a minority of patients responds to therapy and significant immune-related adverse events remain to be minimized. Innovations in engineered drug delivery systems and controlled release strategies can improve drug accumulation at and retention within target cells and tissues in order to enhance therapeutic efficacy while simultaneously reducing drug exposure in off target tissues to minimize the potential for treatment-associated toxicities...
April 25, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28449872/harnessing-macrophage-plasticity-for-tissue-regeneration
#16
REVIEW
Tim D Smith, Raji R Nagalla, Esther Y Chen, Wendy F Liu
Macrophages are versatile and plastic effector cells of the immune system, and contribute to diverse immune functions including pathogen or apoptotic cell removal, inflammatory activation and resolution, and tissue healing. Macrophages function as signaling regulators and amplifiers and influencing their activity is a powerful approach for controlling inflammation or inducing a wound-healing response in regenerative medicine. This review discusses biomaterials-based approaches for altering macrophage activity, approaches for targeting drugs to macrophages, and approaches for delivering macrophages themselves as a therapeutic intervention...
April 25, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28449873/progress-in-tumor-associated-macrophage-tam-targeted-therapeutics
#17
REVIEW
Chayanon Ngambenjawong, Heather H Gustafson, Suzie H Pun
As an essential innate immune population for maintaining body homeostasis and warding off foreign pathogens, macrophages display high plasticity and perform diverse supportive functions specialized to different tissue compartments. Consequently, aberrance in macrophage functions contributes substantially to progression of several diseases including cancer, fibrosis, and diabetes. In the context of cancer, tumor-associated macrophages (TAMs) in tumor microenvironment (TME) typically promote cancer cell proliferation, immunosuppression, and angiogenesis in support of tumor growth and metastasis...
April 24, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28438674/current-state-and-challenges-in-developing-oral-vaccines
#18
REVIEW
Julia E Vela Ramirez, Lindsey A Sharpe, Nicholas A Peppas
While vaccination remains the most cost effective strategy for disease prevention, communicable diseases persist as the second leading cause of death worldwide. There is a need to design safe, novel vaccine delivery methods to protect against unaddressed and emerging diseases. Development of vaccines administered orally is preferable to traditional injection-based formulations for numerous reasons including improved safety and compliance, and easier manufacturing and administration. Additionally, the oral route enables stimulation of humoral and cellular immune responses at both systemic and mucosal sites to establish broader and long-lasting protection...
April 22, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28433739/dual-functional-drug-liposomes-in-treatment-of-resistant-cancers
#19
REVIEW
Li-Min Mu, Rui-Jun Ju, Rui Liu, Ying-Zi Bu, Jing-Ying Zhang, Xue-Qi Li, Fan Zeng, Wan-Liang Lu
Efficacy of regular chemotherapy is significantly hampered by multidrug resistance (MDR) and severe systemic toxicity. The reduced toxicity has been evidenced after administration of drug liposomes, consisting of the first generation of regular drug liposomes, the second generation of long-circulation drug liposomes, and the third generation of targeting drug liposomes. However, MDR of cancers remains as an unsolved issue. The objective of this article is to review the dual-functional drug liposomes, which demonstrate the potential in overcoming MDR...
April 20, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28414079/in-vivo-reprogramming-of-immune-cells-technologies-for-induction-of-antigen-specific-tolerance
#20
REVIEW
Ryan M Pearson, Liam M Casey, Kevin R Hughes, Stephen D Miller, Lonnie D Shea
Technologies that induce antigen-specific immune tolerance by mimicking naturally occurring mechanisms have the potential to revolutionize the treatment of many immune-mediated pathologies such as autoimmunity, allograft rejection, and allergy. The immune system intrinsically has central and peripheral tolerance pathways for eliminating or modulating antigen-specific responses, which are being exploited through emerging technologies. Antigen-specific tolerogenic responses have been achieved through the functional reprogramming of antigen-presenting cells or lymphocytes...
April 14, 2017: Advanced Drug Delivery Reviews
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