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Advanced Drug Delivery Reviews

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https://www.readbyqxmd.com/read/30217519/challenges-and-innovations-of-drug-delivery-in-older-age
#1
REVIEW
Muhammad Suleman Khan, Michael S Roberts
Both drug delivery performance and various age-related physical, mental and physiological changes can affect their effectiveness and safety in elderly patients. The many drug delivery systems developed over the years include recent novel transdermal, nasal, pulmonary and orally disintegrating tablet delivery systems that provide consistent, precise, timely and more targeted absorption. Certain drug delivery systems may be associated with suboptimal outcomes in the elderly because of the nature of drug present, a lack of appreciation of the impact of age-related changes in drug absorption, distribution and clearance on their pharmacokinetics, the limited availability of pharmacokinetic, safety and clinical data...
September 11, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30217518/the-effect-of-low-and-high-penetration-light-on-localized-cancer-therapy
#2
REVIEW
Daniel F Costa, Lívia P Mendes, Vladimir P Torchilin
The design of a delivery system allowing targeted and controlled drug release has been considered one of the main strategies used to provide individualized cancer therapy, to improve survival statistics, and to enhance quality-of-life. External stimuli including low- and high-penetration light have been shown to have the ability to turn drug delivery on and off in a non-invasive remotely-controlled fashion. The success of this approach has been closely related to the development of a variety of drug delivery systems - from photosensitive liposomes to gold nanocages - and relies on multiple mechanisms of drug release activation...
September 11, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30201522/antibody-cytokine-fusion-proteins-biopharmaceuticals-with-immunomodulatory-properties-for-cancer-therapy
#3
REVIEW
Cornelia Hutmacher, Dario Neri
Cytokines have long been used for therapeutic applications in cancer patients. Substantial side effects and unfavorable pharmacokinetics limit their application and may prevent dose escalation to therapeutically active regimens. Antibody-cytokine fusion proteins (often referred to as immunocytokines) may help localize immunomodulatory cytokine payloads to the tumor, thereby activating anticancer immune responses. A variety of formats (e.g., intact IgGs or antibody fragments), molecular targets (e.g., extracellular matrix components and cell membrane antigens) and cytokine payloads have been considered for the development of this novel class of biopharmaceuticals...
September 7, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30189273/physiologically-based-pharmacokinetic-modelling-to-guide-drug-delivery-in-older-people
#4
REVIEW
Manoranjenni Chetty, Trevor N Johnson, Sebastian Polak, Farzaneh Salem, Kosuke Doki, Amin Rostami-Hodjegan
Older patients are generally not included in Phase 1 clinical trials despite being the population group who use the largest number of prescription medicines. Physiologically based pharmacokinetic (PBPK) modelling provides an understanding of the absorption and disposition of drugs in older patients. In this review, PBPK models used for the prediction of absorption and exposure of drugs after parenteral, oral and transdermal administration are discussed. Comparisons between predicted drug pharmacokinetics (PK) and observed PK are presented to illustrate the accuracy of the predictions by the PBPK models and their potential use in informing clinical trial design and dosage adjustments in older patients...
September 4, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30189271/the-potential-to-treat-lung-cancer-via-inhalation-of-repurposed-drugs
#5
REVIEW
Wing-Hin Lee, Ching-Yee Loo, Maliheh Ghadiri, Chean-Ring Leong, Paul M Young, Daniela Traini
Lung cancer is a highly invasive and prevalent disease with ineffective first-line treatment and remains the leading cause of cancer death in men and women. Despite the improvements in diagnosis and therapy, the prognosis and outcome of lung cancer patients is still poor. This could be associated with the lack of effective first-line oncology drugs, formation of resistant tumors and non-optimal administration route. Therefore, the repurposing of existing drugs currently used for different indications and the introduction of a different method of drug administration could be investigated as an alternative to improve lung cancer therapy...
September 4, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30189270/orally-inhaled-migraine-therapy-where-are-we-now
#6
REVIEW
Kevin W Stapleton
Migraine is a debilitating disease that affects 9% of men and 19% of women worldwide with high socio-economic and personal impact. Surveys indicate that migraineurs are among the most dissatisfied with available therapeutic options, predominantly given via oral or injectable routes, citing side effects as the primary complaint. Orally inhaled therapies have the potential to offer faster onset of action with fewer side effects compared to existing therapies, yet development has stalled. Despite emerging therapies such as calcitonin gene-related peptide antagonists, there are still good opportunities for repositioning migraine drugs via the inhaled route...
September 4, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30189272/corrigendum-to-current-state-and-challenges-in-developing-oral-vaccines-adv-drug-deliv-rev-114-2017-116-131
#7
Julia E Vela Ramirez, Lindsey A Sharpe, Nicholas A Peppas
No abstract text is available yet for this article.
September 3, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30176280/plant-virus-based-materials-for-biomedical-applications-trends-and-prospects
#8
REVIEW
Sabine Eiben, Claudia Koch, Klara Altintoprak, Alexander Southan, Günter Tovar, Sabine Laschat, Ingrid M Weiss, Christina Wege
Nanomaterials composed of plant viral components are finding their way into medical technology and health care, as they offer singular properties. Precisely shaped, tailored virus nanoparticles (VNPs) with multivalent protein surfaces are efficiently loaded with functional compounds such as contrast agents and drugs, and serve as carrier templates and targeting vehicles displaying e.g. peptides and synthetic molecules. Multiple modifications enable uses including vaccination, biosensing, tissue engineering, intravital delivery and theranostics...
August 31, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30172925/physically-triggered-nanosystems-based-on-two-dimensional-materials-for-cancer-theranostics
#9
REVIEW
Ding-Kun Ji, Cécilia Ménard-Moyon, Alberto Bianco
There is an increasing demand to develop effective methods for treating malignant diseases to improve healthcare in our society. Stimuli-responsive nanosystems, which can respond to internal or external stimuli are promising in cancer therapy and diagnosis due to their functionality and versatility. As a newly emerging class of nanomaterials, two-dimensional (2D) nanomaterials have attracted huge interest in many different fields including biomedicine due to their unique physical and chemical properties. In the past decade, stimuli-responsive nanosystems based on 2D nanomaterials have been widely studied, showing promising applications in cancer therapy and diagnosis, including phototherapies, magnetic therapy, drug and gene delivery, and non-invasive imaging...
August 31, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30172924/current-and-upcoming-therapies-to-modulate-skin-scarring-and-fibrosis
#10
REVIEW
João Q Coentro, Eugenia Pugliese, Geoffrey Hanley, Michael Raghunath, Dimitrios I Zeugolis
Skin is the largest organ of the human body. Being the interface between the body and the outer environment, makes it susceptible to physical injury. To maintain life, nature has endowed skin with a fast healing response that invariably ends in the formation of scar at the wounded dermal area. In many cases, skin remodelling may be impaired, leading to local hypertrophic scars or keloids. One should also consider that the scarring process is part of the wound healing response, which always starts with inflammation...
August 30, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30172923/use-of-plant-viruses-and-virus-like-particles-for-the-creation-of-novel-vaccines
#11
REVIEW
Ina Balke, Andris Zeltins
In recent decades, the development of plant virology and genetic engineering techniques has resulted in the construction of plant virus-based vaccines for protection against different infectious agents, cancers and autoimmune diseases in both humans and animals. Interaction studies between plant viruses and mammalian organisms have suggested that plant viruses and virus-like particles (VLPs) are safe and noninfectious to humans and animals. Plant viruses with introduced antigens are powerful vaccine components due to their strongly organized, repetitive spatial structure; they can elicit strong immune responses similar to those observed with infectious mammalian viruses...
August 30, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30125606/application-of-aptamers-for-in-vivo-molecular-imaging-and-theranostics
#12
REVIEW
Bouvier-Müller Alix, Ducongé Frédéric
Nucleic acid aptamers are small three-dimensional structures of oligonucleotides selected to bind to a target of interest with high affinity and specificity. In vitro, aptamers already compete with antibodies to serve as imaging probes, e.g. for microscopy or flow cytometry. However, they are also increasingly used for in vivo molecular imaging. Accordingly, aptamers have been evaluated over the last twenty years in almost every imaging modality, including single photon emission computed tomography, positron emission tomography, magnetic resonance imaging, fluorescence imaging, echography, and x-ray computed tomography...
August 17, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30125605/therapeutic-aptamers-in-discovery-preclinical-and-clinical-stages
#13
REVIEW
Said I Ismail, Walhan Alshaer
The aptamer field witnessed steady growth during the past 28 years as evident from the exponentially increasing number of related publications. The field is "coming of age", but like other biomedical research areas facing a global push towards translational research to carry ideas from bench- to bedside, there is pressure to show impact for aptamers at the clinical end. Being easy-to-make, non-immunogenic, stable and high-affinity nano-ligands, aptamers are perfectly poised to move in this direction...
August 17, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30125604/aptamer-based-targeted-therapy
#14
REVIEW
Guizhi Zhu, Xiaoyuan Chen
Precision medicine holds great promise to harness genetic and epigenetic cues for targeted treatment of a variety of diseases, ranging from many types of cancers, neurodegenerative diseases, to cardiovascular diseases. The proteomic profiles resulting from the unique genetic and epigenetic signatures represent a class of relatively well accessible molecular targets for both interrogation (e.g., diagnosis, prognosis) and intervention (e.g., targeted therapy) of these diseases. Aptamers are promising for such applications by specific binding with cognate disease biomarkers...
August 17, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30118723/challenges-and-innovations-of-delivering-medicines-to-older-adults
#15
REVIEW
Danijela Gnjidic, Andy Husband, Adam Todd
Older adults with multimorbidity, polypharmacy, and complex health needs are the major consumer of health care. Ensuring that medicines are used safely, effectively, and delivered efficiently in this population is challenging. In this context, the approach to medicines delivery should seek to overcome some of the difficulties of delivering medicines to older people, and ensure each medication is delivered by the optimal and most convenient route for the patient in question. However, this poses significant obstacles, as the development of medicines suitable for use in older populations does not often account for complex health needs, potential challenges in relation to drug disposition, safety of excipients and limitations with practical usability of dosage forms...
August 15, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30107211/muscle-fibrosis-in-the-soft-palate-delivery-of-cells-growth-factors-and-anti-fibrotics
#16
REVIEW
Johannes W Von den Hoff, Paola L Carvajal Monroy, Edwin M Ongkosuwito, Toin H van Kuppevelt, Willeke F Daamen
The healing of skeletal muscle injuries after major trauma or surgical reconstruction is often complicated by the development of fibrosis leading to impaired function. Research in the field of muscle regeneration is mainly focused on the restoration of muscle mass while far less attention is paid to the prevention of fibrosis. In this review, we take as an example the reconstruction of the muscles in the soft palate of cleft palate patients. After surgical closure of the soft palate, muscle function during speech is often impaired by a shortage of muscle tissue as well as the development of fibrosis...
August 11, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30096336/phage-therapy-for-respiratory-infections
#17
REVIEW
Rachel Yoon Kyung Chang, Martin Wallin, Yu Lin, Sharon Sui Yee Leung, Hui Wang, Sandra Morales, Hak-Kim Chan
A respiratory infection caused by antibiotic-resistant bacteria can be life-threatening. In recent years, there has been tremendous effort put towards therapeutic application of bacteriophages (phages) as an alternative or supplementary treatment option over conventional antibiotics. Phages are natural parasitic viruses of bacteria that can kill the bacterial host, including antibiotic-resistant bacteria. Inhaled phage therapy involves the development of stable phage formulations suitable for inhalation delivery followed by preclinical and clinical studies for assessment of efficacy, pharmacokinetics and safety...
August 7, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30075168/acellular-and-cellular-approaches-to-improve-diabetic-wound-healing
#18
REVIEW
Hongkwan Cho, Michael R Blatchley, Elia J Duh, Sharon Gerecht
Chronic diabetic wounds represent a huge socioeconomic burden for both affected individuals and the entire healthcare system. Although the number of available treatment options as well as our understanding of wound healing mechanisms associated with diabetes has vastly improved over the past decades, there still remains a great need for additional therapeutic options. Tissue engineering and regenerative medicine approaches provide great advantages over conventional treatment options, which are mainly aimed at wound closure rather than addressing the underlying pathophysiology of diabetic wounds...
August 1, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30059703/computational-modelling-of-drug-delivery-to-solid-tumour-understanding-the-interplay-between-chemotherapeutics-and-biological-system-for-optimised-delivery-systems
#19
REVIEW
Wenbo Zhan, Moath Alamer, Xiao Yun Xu
Drug delivery to solid tumour involves multiple physiological, biochemical and biophysical processes taking place across a wide range of length and time scales. The therapeutic efficacy of anticancer drugs is influenced by the complex interplays among the intrinsic properties of tumours, biophysical aspects of drug transport and cellular uptake. Mathematical and computational modelling allows for a well-controlled study on the individual and combined effects of a wide range of parameters on drug transport and therapeutic efficacy, which would not be possible or economically viable through experimental means...
July 29, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30059702/strategies-to-overcome-the-polycation-dilemma-in-drug-delivery
#20
REVIEW
Andreas Bernkop-Schnürch
Because of polycationic auxiliary agents such as chitosan, polyethyleneimine and cell penetrating peptides as well as cationic lipids assembling to polycationic systems, drug carriers can tightly interact with cell membranes exhibiting a high-density anionic charge. Because of these interactions the cell membrane is depolarized and becomes vulnerable to various uptake mechanisms. On their way to the target site, however, the polycationic character of all these drug carriers is eliminated by polyanionic macromolecules such as mucus glycoproteins, serum proteins, proteoglycans of the extracellular matrix (ECM) and polyanionic surface substructures of non-target cells such as red blood cells...
July 29, 2018: Advanced Drug Delivery Reviews
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