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Archives of Gynecology and Obstetrics

Mahboubeh Vatanparast, Mohammad Ali Khalili, Nahid Yari, Bryan Woodward, Mehdi Mohsenzadeh
PURPOSE: Ovarian tissue (OT) cryopreservation is a treatment option for fertility preservation among young cancer patients. However, the procedure may involve a reduction in the GDF9-β expression and a delay in follicular growth after thawing and transplantation. The aim of this study was to evaluate whether supplementation of GDF9-β can compensate the reduction of this factor during the cryopresevation process and promote folliculogenesis after transplantation of thawed sheep ovarian tissue...
July 12, 2018: Archives of Gynecology and Obstetrics
Junfang Yang, Jinsong Han, Fuli Zhu, Yu Wang
AIM: The aim of this study was to identify factors associated with pessary fitting, continued use of pessary and satisfaction of patients with pelvic organ prolapse. METHODS: A retrospective study was conducted in patients who received an initial pessary fitting. The clinical characteristics of these patients were recorded. The Pelvic Floor Disability Index PFDI-20 and PFIQ-7 were used to assess pelvic floor dysfunction and quality of life. Complications, satisfaction degree, and reasons for abandonment were recorded during the follow-up...
July 5, 2018: Archives of Gynecology and Obstetrics
Cheng Liu, Chongdong Liu, Qiushi Wang, Zhenyu Zhang
OBJECTIVES: We aimed to systematically assess the relationship between folic acid supplementation in pregnancy and risk of preeclampsia and gestational hypertension. METHODS: The relevant studies were included by retrieving the Embase, PubMed and Cochrane library databases. Data extraction was conducted by two investigators independently. The risk ratio (RR) and 95% confidence interval (CI) were used as effect indexes to evaluate the relationship between folic acid supplementation and risk of gestational hypertension or preeclampsia...
July 5, 2018: Archives of Gynecology and Obstetrics
Eyal Krispin, Alyssa Hochberg, Rony Chen, Arnon Wiznitzer, Eran Hadar, Adi Borovich
OBJECTIVE: To determine the association between antenatal corticosteroid treatment and neonatal complications in diabetic mothers delivering after 34 weeks of gestation. METHODS: A retrospective cohort study of women with singleton pregnancies diagnosed with gestational diabetes who delivered after 34 weeks of gestation in a university-affiliated medical center (2012-2016). Mothers treated with corticosteroids prior to 34 + 0 weeks of gestation were divided according to gestational age at delivery: late-preterm (34 + 0 to 36 + 6) and term (37 + 0 to 41 + 6)...
July 5, 2018: Archives of Gynecology and Obstetrics
Hongling Peng, Qiao Wang, Xiaorong Qi, Xi Wang, Xia Zhao
INTRODUCTION: Orlistat possesses anti-tumor capacity by inducing apoptosis in ovarian cancer cells. However, the mechanism is not clearly understood. Emerging evidence indicates the overlaps between autophagy and apoptosis. In this study, we have investigated the role of autophagy in orlistat-induced apoptosis in ovarian cancer (OC) cells. METHODS: The effect of orlistat on apoptosis was evaluated in SKOV3 and A2780 cell lines by MTT and TUNEL assay. The formations of autophagosomes were observed by acridine orange and GFP-LC3 fluorescence...
July 4, 2018: Archives of Gynecology and Obstetrics
Zhengchen Guo, Yuanjing Hu, Liqin Yuan, Na Li, Tian Wang
PURPOSE: To study the predictive value of the DNA methylation levels of JAM3, SOX1, SLIT2, C13ORF18, and TERT in the cervical intraepithelial neoplasia prognosis. METHOD: In the present study, 139 cases were collected and followed up for 24 months. The DNA methylation levels of JAM3, SOX1, SLIT2, C13ORF18, and TERT were tested from their exfoliated cells. One-way ANOVA, receiver operating characteristic (ROC) curve analyses were conducted to analyze the data. RESULTS: The DNA methylation of the five genes was associated with prognosis of CIN...
July 3, 2018: Archives of Gynecology and Obstetrics
Ahmet Namazov, Leonti Grin, Resul Karakus, Mehmet Uludogan, Habibe Ayvaci
PURPOSE: The aim of this study is to assess the effects of maternal nifedipine administration on placental and fetal blood flow. METHODS: A total of 29 patients with preterm labor diagnosis admitted to the tertiary care center, Zeynep Kamil Hospital, were evaluated. Before and 24-48 h after administration of oral nifedipine, Doppler ultrasound scan was carried out to measure fetal middle cerebral artery, ductus venosus, umbilical artery, and maternal uterine artery blood flow...
July 3, 2018: Archives of Gynecology and Obstetrics
Liran Hiersch, Howard Berger, Rania Okby, Joel G Ray, Michael Geary, Sarah D Mcdonald, Beth Murry-Davis, Catherine Riddell, Ilana Halperin, Haroon Hasan, Jon Barrett, Nir Melamed
OBJECTIVE: To compare the incidence and risk factors for gestational diabetes mellitus (GDM) between women with twin and singleton pregnancies. METHODS: Retrospective study of all women who had a twin or singleton birth in Ontario (2012-2016). Risk ratios (RR) and 95% CIs for GDM (stratified by type of treatment) were adjusted for relevant confounding variables. Multivariable Poisson regression analysis was used to identify risk factors for GDM in twin and singleton gestations...
July 3, 2018: Archives of Gynecology and Obstetrics
José L Carrasco-Juan, Hugo Álvarez-Argüelles-Cabrera, Carmen Martín-Corriente, Ricardo Gutiérrez-García, Abián Vega-Falcón, Idaira Expósito-Afonso, Rafael Méndez-Medina, Lucio Díaz-Flores
PURPOSE: We are conducting a prospective study trying to determine, in both sexes, the frequency of appearance of ectopic Leydig cells, their preferred location, their relationship with nerve structures and the possible causes of their appearance. METHODS: We have studied 86 cases that were removed according to different clinical indications for pathological study: uterine leyomiomas (n = 12), ovarian cystadenoma (n = 4), endometrial hyperplasia (n = 8), endometrial carcinoma (n = 12), cervical carcinoma (n = 4), seminoma (n = 4), fallopian tube ligatures (n = 24), vasectomies (n = 8), nonspecific orchiepididymitis (n = 2), and unknown (n = 8)...
July 3, 2018: Archives of Gynecology and Obstetrics
Yu Xiao, Min Wang, Kai Liu
PURPOSE: To evaluate whether seasonal variations can affect the outcomes of in vitro fertilization (IVF) and embryo transfer (ET). METHODS: The data of 2868 IVF-ET cycles over 5 years from patients treated for fallopian tube factors, oligospermia, and asthenospermia were collected retrospectively. The cycles were divided into four seasonal groups based on the day of ET. All cycles were performed using the gonadotropin-releasing hormone agonist and antagonist protocols...
July 3, 2018: Archives of Gynecology and Obstetrics
Oliver Graupner, Silvia M Lobmaier, Javier U Ortiz, Anne Karge, Bettina Kuschel
PURPOSE: The soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio has been shown to be a useful parameter for the diagnosis and prediction of preeclampsia (PE). An increased sFlt-1/PlGF ratio can be closely linked to the need to deliver. The aim of the study was to examine the mean time until delivery (MTUD) in pregnant women with a strongly increased sFlt-1/PlGF ratio. METHODS: From 2010 to 2018, the sFlt-1/PlGF ratio was determined in 995 singleton pregnancies with diagnosis or suspicion of PE/HELLP syndrome and/or intrauterine growth restriction (IUGR)...
July 2, 2018: Archives of Gynecology and Obstetrics
Chieh-Chen Wu, Ya-Yu Yu, Hsuan-Chia Yang, Phung Anh Nguyen, Tahmina Nasrin Poly, Md Mohaimenul Islam, Usman Iqbal, Hafash Arshed Ali Khan, Yao-Chin Wang, Yung-Tzu Cheng, Yu-Chuan Li, Wen-Shan Jian
PURPOSE: To investigate whether the use of levothyroxine was associated with breast cancer risk. METHODS: We conducted a population-based case-control study in Taiwan. Cases consisted of all patients who were aged 20 years and older, and had a first-time diagnosis of breast cancer for the period between 2001 and 2011. The controls were matched to the cases by age, sex, year, and month of diagnosis. Adjusted odd ratios (ORs) and 95% confidence intervals (CIs) were estimated by a conditional logistic regression...
June 30, 2018: Archives of Gynecology and Obstetrics
Mucize Eric Ozdemir, Isil Uzun Cilingir, Gulsah Ilhan, Elif Yildiz, Karolin Ohanoglu
PURPOSE: The aim of this study was to assess the impact of systematic birth preparation program on fear of vaginal delivery and quality of life (QoL) in pregnant women who request elective cesarean delivery without any obstetric indication. METHODS: This study was conducted prospectively. A total of 100 women who requested elective cesarean delivery due to psychosocial reasons were included into the study. Women were divided into two groups according to their desire to participate in the systematic birth preparation program...
June 30, 2018: Archives of Gynecology and Obstetrics
Yaakov Melcer, R Maymon, K Krajden Haratz, I Goldrat, M Shavit, I Ben-Ami, Z Vaknin
PURPOSE: To assess fetal central nervous system (CNS) abnormalities presenting as major findings leading to late termination of pregnancy (late TOP) performed ≥ 24 weeks' gestation. METHOD: The study population included 2789 pregnant women that underwent late TOP in our institute between the years 1998 and 2015. RESULTS: Fifty-seven cases (2.0%) underwent late TOP because of fetal CNS indications and are the subjects of the current study...
June 29, 2018: Archives of Gynecology and Obstetrics
Stella Capriglione, Marco Antonio Palumbo, Andrea Miranda, Ferdinando Antonio Gulino
No abstract text is available yet for this article.
June 29, 2018: Archives of Gynecology and Obstetrics
Shikha Bathwal, Astha Chakravarty, Sunita Sharma, Soma Singh, Indranil Saha, Baidyanath Chakravarty
PURPOSE: An alternative option to human chorionic gonadotropin (hCG) is GnRH agonist (GnRH-a) for ovulation trigger in intrauterine insemination (IUI) cycles. This study aims to compare the efficacy of GnRH-a with hCG in women with history of follicular-endometrial asynchrony after clomiphene in IUI cycles. METHODS: This prospective observational study recruited 631 women with unexplained infertility and follicular-endometrial asynchrony (follicle ≥ 18 mm, endometrial thickness (ET) < 7 mm) in previous two failed clomiphene/IUI cycles...
June 28, 2018: Archives of Gynecology and Obstetrics
Jucilene Freitas Dos Santos, Cibelle de Melo Bastos Cavalcante, Fabiano Timbó Barbosa, Daniel Leite Góes Gitaí, Marcelo Duzzioni, Cristiane Queixa Tilelli, Ashok K Shetty, Olagide Wagner de Castro
OBJECTIVE: Crack cocaine consumption is one of the main public health challenges with a growing number of children intoxicated by crack cocaine during the gestational period. The primary goal is to evaluate the accumulating findings and to provide an updated perspective on this field of research. METHODS: Meta-analyses were performed using the random effects model, odds ratio (OR) for categorical variables and mean difference for continuous variables. Statistical heterogeneity was assessed using the I-squared statistic and risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale...
June 27, 2018: Archives of Gynecology and Obstetrics
Preeyaporn Jirakittidul, Supatra Sirichotiyakul, Chidchanok Ruengorn, Kitirat Techatraisak, Busaba Wiriyasirivaj
OBJECTIVE: To investigate the association between iron supplementation during early pregnancy and the presence of de novo hypertension after 20 weeks' gestation (either gestational hypertension or pre-eclampsia). STUDY DESIGN: Retrospective cohort study. METHODS: This study retrospectively reviewed the medical records of non-anemic pregnant women who received first antenatal care at the Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand, during the June 2009-December 2010 study period...
June 27, 2018: Archives of Gynecology and Obstetrics
Kuntharee Traisrisilp
No abstract text is available yet for this article.
June 27, 2018: Archives of Gynecology and Obstetrics
Zhifu Zhi, Wenmei Yang, Liling Liu, XiaoLi Jiang, Lihong Pang
PURPOSE: To analyze the effects of the hypoxia-inducible factor 1-alpha (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway on villous angiogenesis in early missed abortion. METHODS: Immunohistochemical assays were performed to detect the expression of micro-vessel density (MVD), HIF-1α, and VEGF in villous tissue samples from 30 missed abortions and 30 elective abortions in early pregnancy. We further analyzed the correlation between HIF-1α/VEGF and MVD...
June 27, 2018: Archives of Gynecology and Obstetrics
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