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Archives of Gynecology and Obstetrics

Zhuyan Shao, Qiang Wen, Tao Zhu, Wei Jiang, Yu Kang, Conjian Xu, Shihua Wang
PURPOSE: The present study investigated the preventive effect of the cyclooxygenase (COX)-2 inhibitor, celecoxib, in 7,12-dimethylbenz[a]anthracene (DMBA)-induced ovarian cancer in a rat model. METHODS: A diet containing celecoxib (1500 ppm) was started 2 weeks before the introduction of DMBA. DMBA-soaked cotton threads were surgically applied to induce ovarian cancer in female Wistar rats. Tumor growth and survival were observed for 24 weeks. RESULTS: During the study period, an overall tumor incidence of 97...
September 21, 2018: Archives of Gynecology and Obstetrics
Rossana Di Paola, Simone Garzon, Sara Giuliani, Antonio Simone Laganà, Marco Noventa, Francesca Parissone, Carlotta Zorzi, Ricciarda Raffaelli, Fabio Ghezzi, Massimo Franchi, Stefano Zaffagnini
PURPOSE: To evaluate the potential application of a nomogram based on woman's age and ovarian reserve markers as a tool to optimize the follicle-stimulating hormone (FSH) starting dose in intrauterine insemination (IUI) cycles. METHODS: We conducted a retrospective analysis enrolling 179 infertile women undergoing controlled ovarian stimulation (COS), followed by IUI. Each woman received an FSH starting dose according to clinical decision. After collecting data about COS and IUI procedures, we calculated the FSH starting dose according to the nomogram...
September 21, 2018: Archives of Gynecology and Obstetrics
Yongming Du
No abstract text is available yet for this article.
September 21, 2018: Archives of Gynecology and Obstetrics
Philipp Harter, Andreas du Bois, Jalid Sehouli, Sven Mahner, Ignace Vergote, Luis Chiva, Antonio Gonzalez-Martin, Christina Fotopoulou
Hyperthermic intraperitoneal chemotherapy (HIPEC) is promoted by some as a standard treatment for peritoneal carcinomatosis of epithelial ovarian cancer (EOC) and other tumor entities, despite lack of robust data supporting this. Publicly available evidence addressing the value of HIPEC in EOC is rather inconclusive, revealing contradictory and inconsistent results while some studies even report harm to the patients from a higher morbidity. On this ground, we cannot recommend the implementation and use of HIPEC outside of a randomized clinical trial setting...
September 20, 2018: Archives of Gynecology and Obstetrics
Yun Huang, Jingyi Li, Fang Zhang, Yifeng Liu, Gufeng Xu, Jing Guo, Runjv Zhang, Yiqing Wu, Juan Liu, Kai Chen, Wei Zhao, Wei Wu, Yanjun Hu, Guangdi Chen, Dan Zhang
PURPOSE: The occurrence of diminished ovarian reserve (DOR) in women was growing in recent years. Although in vitro fertilization and embryo transfer (IVF-ET) became an effective treatment for DOR, the live-birth (LB) rate remains unsatisfactory. This study aimed to investigate the impact factors of LB rate in women with DOR undergoing assisted reproduction. METHODS: This was a single-center retrospective cohort study. A total of 2277 IVF-ET or ICSI cycles from 1957 DOR women were analysed...
September 19, 2018: Archives of Gynecology and Obstetrics
Jana Nickol, Sebastian Berlit, Stefanie Lis, Amadeus Hornemann, Charalambos Tsagogiorgas, Marc Sütterlin, Benjamin Tuschy
PURPOSE: To evaluate changes in hemodynamic effects of intramyometrial epinephrine injection for blood loss reduction in laparoscopic myomectomy. METHODS: A total of 185 women with symptomatic uterine fibroids who underwent laparoscopic myomectomy were enrolled in this study. Eighty-six women (study collective) received an intramyometrial injection of epinephrine and were compared to ninety-nine women (control collective) who underwent laparoscopic myomectomy without an intramyometrial epinephrine injection...
September 18, 2018: Archives of Gynecology and Obstetrics
Klara Rosta, Johannes Ott, Fanni Kelemen, Wilhelm Temsch, Tobias Lahner, Theresa Reischer, Hanns Helmer, Aniko Somogyi
PURPOSE: To determine the incidence of gestational diabetes mellitus (GDM) in pregnant women who received vaginal progesterone due to short cervical length or to prevent recurrent preterm birth. METHODS: In this retrospective study, we included 190 women with singleton pregnancies at risk for preterm birth who received vaginal natural progesterone (200 mg daily between gestational weeks 16 + 0 and 36 + 0) for a minimum of 4 weeks and delivered > 28 weeks...
September 17, 2018: Archives of Gynecology and Obstetrics
Maike Katja Kahr, Romana Brun, Roland Zimmermann, Denise Franke, Christian Haslinger
PURPOSE: Reliable real-time estimation of blood loss is crucial for the prompt management of postpartum hemorrhage (PPH), which is one of the major obstetric complications worldwide. Our study aims at the validation of feasibility and precision of measured blood loss (MBL) with a quantitative real-time measurement system during (1) vaginal delivery and (2) cesarean section by comparison with a hemoglobin-based formula for blood loss as an objective control. This is the first study to include a reasonable number of patients in an everyday clinical setting...
September 17, 2018: Archives of Gynecology and Obstetrics
Semir Kose, Gamze Tuna, Gülnar Nuriyeva, Sabahattin Altunyurt, Gül Hüray Islekel, Omer Erbil Doğan
PURPOSE: To analyze the clinical and laboratory factors that potentially affect the diagnosis-to-delivery time in preeclamptic pregnancies. METHODS: In this cross-sectional study, we followed 24 early onset preeclampsia (E-PE) and 26 late-onset preeclampsia (L-PE) cases. Maternal serum samples were obtained at the time of diagnosis and stored at - 80 °C until ELISA analysis for soluble fms-like tyrosine kinase-1 (SFlt-1) and placental growth factor (PlGF) levels...
September 17, 2018: Archives of Gynecology and Obstetrics
Shigeki Matsubara
No abstract text is available yet for this article.
September 17, 2018: Archives of Gynecology and Obstetrics
Angela Köninger, Antje Enekwe, Pawel Mach, Dimitrios Andrikos, Boerge Schmidt, Mirjam Frank, Cahit Birdir, Rainer Kimmig, Alexandra Gellhaus, Hans Dieplinger
PURPOSE: Oxidative stress is involved in the pathogenesis of hypertensive disorders such as preeclampsia (PE) and associated with the human vitamin E-binding protein afamin. The aim of this study was, therefore, to analyse afamin in the first trimester of patients developing PE later in pregnancy and in control subjects without pregnancy complications. METHODS: In this retrospective study, 137 serum samples from the first trimester of pregnancy were analysed in a case-control study design...
September 15, 2018: Archives of Gynecology and Obstetrics
Ling Zhang, Wei-Hai Xu, Xiao-Hua Fu, Qiong-Xiao Huang, Xiao-Yan Guo, Lin Zhang, Shi-Shi Li, Jing Zhu, Jing Shu
OBJECTIVE: The aim of this meta-analysis is to explore the beneficial role of granulocyte colony-stimulating factor (G-CSF) on infertile women under artificial reproduction technology treatment. METHOD: Medline, Embase and ISI Web of Science databases were searched to identify relevant randomized control trials. Studies before July, 2017 were included for primary screening. Meta-analysis of the total and subgroup patients was conducted, and relative risks (RRs) and their 95% confidence intervals (95% CI) were calculated by a fixed-effect model if no heterogeneity (evaluated as I2 statistic) existed...
September 15, 2018: Archives of Gynecology and Obstetrics
Christian M Domröse, Sandra Bremer, Caroline Buczek, Annegret Geipel, Christoph Berg, Astrid Hellmund, Ulrich Gembruch, Arne Willruth
PURPOSE: To analyze fetal cerebral malformations with late termination of pregnancy (TOP) and to evaluate the rate of cases that could have been detected earlier using international recommended requirements of sonographic examination of the fetal central nervous system (CNS). MATERIALS AND METHODS: Cases of singleton pregnancies above 18 + 0 weeks of gestation ending in late TOP due to fetal CNS malformations between 2002 and 2011 were retrospectively reviewed...
September 14, 2018: Archives of Gynecology and Obstetrics
Claudia Teixeira da Costa Lodi, Márcia Antoniazi Michelin, Maria Inês Miranda Lima, Eddie Fernando Candido Murta, Letícia da Conceição Braga, Leticia Montes, Victor Hugo Melo
PURPOSE: Aberrant DNA methylation is present in virtually all types of human cancer. There is no clear evidence that methylation status can predict bad prognosis in patients with CIN recurrence in HIV infected. This study evaluates the relationship between aberrant methylation of CpG islands of CDH1, TIMP3 and MGMT genes and CIN recurrence in HIV-infected and -noninfected women. METHODS: This is a nested case-control study involving 33 cases with CIN recurrence and 114 controls without recurrence, HIV infected and noninfected, treated with LEEP, between 1999 and 2004...
September 14, 2018: Archives of Gynecology and Obstetrics
Ellen J Hoekman, Dan Knoester, Alexander A W Peters, Frank W Jansen, Cornelis D de Kroon, Carina G J M Hilders
PURPOSE: To evaluate the effectiveness of ovarian transposition (OT) prior to radiation therapy (RT) and to evaluate the effect of age on ovarian survival (OS) after OT. METHODS: We performed a retrospective control study, with women (aged < 45 years) who underwent OT prior to pelvic radiation, versus women diagnosed with cervical cancer and treated with hysterectomy/trachelectomy and radiation therapy. All women were treated between 1989 and 2010. The 5 years OS rate was calculated, with a sub-analysis for age (25-30; 31-35 and 36-40 years)...
September 14, 2018: Archives of Gynecology and Obstetrics
Ariel Chackowicz, Nicholas Czuzoj-Shulman, Haim Arie Abenhaim
PURPOSE: In women with preterm premature rupture of membranes (PPROM), particularly those with suspected chorioamnionitis, the benefit of tocolysis on neonatal outcome remains unclear. Our purpose was to evaluate the effect of tocolysis on neonatal septic death in women with PPROM with and without chorioamnionitis. METHODS: A retrospective cohort study was used to address our study objective. We created a cohort consisting of all live births between 24 and 32 weeks' gestation that were registered in the Linked Birth and Infant Death data files (2009-2013) from the United States...
September 11, 2018: Archives of Gynecology and Obstetrics
Yilin Wang, Lili Zhang, Xiaoxia Che, Wenzhi Li, Zhiming Liu, Jie Jiang
PURPOSE: The prevalence of endometrial cancer (EC) is increasing worldwide. Progestin therapy is effective for both early stage EC patients who require preserving fertility and advanced or recurrent patients. Progestin resistance resulting from downregulation of progesterone receptor (PR) remains a major problem, and its mechanism is currently unclear. It was demonstrated that Sirtuin 1 (SIRT1), forkhead transcription factor 1 (FoxO1) and sterol regulatory element binding protein-1 (SREBP-1) may act as a pathway and play crucial roles in the development of EC in our previous studies...
September 11, 2018: Archives of Gynecology and Obstetrics
Martin Weiss, Matthias B Stope
Non-thermal application of physical plasma is rapidly gaining importance for the future therapy and prevention of chronic inflammatory diseases and tumors. Here, we outline the importance of this innovative and less invasive therapy option, particulary for the treatment and prevention of gynecological cancers.
September 11, 2018: Archives of Gynecology and Obstetrics
Eva Schwenke, Peter A Fasching, Florian Faschingbauer, Jutta Pretscher, Sven Kehl, Roberta Peretz, Andrea Keller, Lothar Häberle, Anna Eichler, Viktoria Irlbauer-Müller, Ulf Dammer, Matthias W Beckmann, Michael Schneider
PURPOSE: The aim of this study was to evaluate maternal, prenatal, perinatal, and postpartum parameters as risk factors for the later development of an attention deficit hyperactivity disorder (ADHD) in the child. METHODS: Women who had given birth at Erlangen University Hospital between 1996 and 1999 were sent a questionnaire in 2009. The results of the questionnaire were correlated with the prospectively collected data for the births in 1996-1999. RESULTS: A total of 573 mother and child pairs were analyzed...
September 8, 2018: Archives of Gynecology and Obstetrics
Florian Ebner, Thomas W P Friedl, Amelie de Gregorio, Krisztian Lato, Inga Bekes, Wolfgang Janni, Nikolaus de Gregorio
BACKGROUND: Despite a trend for less radical surgical approaches in breast cancer due to better understanding of tumour biology and new treatment options such as neoadjuvant chemotherapy (NAC) and intra-operative radiotherapy (IORT), seroma production remains one of the main surgical side effects that can result in prolonged recovery, delay of radiotherapy and patient discomfort. The aim of this study is to provide an update on risk factors for seroma production after breast cancer surgery considering the latest treatment options...
September 8, 2018: Archives of Gynecology and Obstetrics
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