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Archives of Gynecology and Obstetrics

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https://www.readbyqxmd.com/read/28224270/intrapartal-pelvic-floor-protection-a-pragmatic-and-interdisciplinary-approach-between-obstetrics-and-urogynecology
#1
Markus Huebner, Sara Y Brucker, Ralf Tunn, Gert Naumann, Christl Reisenauer, Harald Abele
Pelvic floor protection is an issue of increasing relevance. This article sought to summarize the session at last year's annual meeting of the German Society of Gynecology and Obstetrics (DGGG) in Stuttgart (10/2016) called "Urogynecology 2020-what is the optimal rate of cesarean section-does urogynecology have to deal with Obstetrics?". The main focus was set on the two important anatomical structures, the levator ani muscle and the anal sphincters. Operative vaginal delivery, epidural anesthesia, and episiotomy are subject to discussion...
February 21, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28224269/severe-pelvic-organ-prolapse-treated-by-vaginal-native-tissue-repair-long-term-analysis-of-outcomes-in-146-patients
#2
Michele Carlo Schiavi, Giorgia Perniola, Violante Di Donato, Virginia Sibilla Visentin, Flaminia Vena, Anna Di Pinto, Marzio Angelo Zullo, Marco Monti, Pierluigi Benedetti Panici
AIMS: The aim of this study was to assess the effectiveness and safety of vaginal native tissue repair (VNTR) as a surgical treatment for severe pelvic organ prolapse (POP) and, second, to evaluate the impact on the quality-of-life (QoL) and sexual function. METHODS: Women with symptomatic POP (≥III stage according to POP Quantification System) with or without stress urinary incontinence (SUI) underwent VNTR. The clinical stage, 3-day voiding diary, and urodynamic testing were evaluated in the preoperative and postoperative times, respectively...
February 21, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28224268/serum-serotonin-leptin-and-adiponectin-changes-in-women-with-postpartum-depression-controlled-study
#3
Gazi Yildiz, Mehmet Baki Senturk, Pinar Yildiz, Yusuf Cakmak, Mehmet Sukru Budak, Erbil Cakar
PURPOSE: Postpartum depression (PPD) affects nearly 10% of mothers after delivery and has many serious results. Although many factors associated with PPD, the etiology, and pathophysiology of PPD are not known completely. The relationship between serum serotonin concentration and depression is well known, but there are no enough data regarding the serum change of leptin and adiponectin. The aims of this study are to research the level of serum serotonin, leptin,s and adiponectin concentrations in women with PPD...
February 21, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28210863/healthcare-professionals-response-to-intrapartum-death-a-cross-sectional-study
#4
Karen McNamara, S Meaney, O O'Connell, M McCarthy, R A Greene, K O'Donoghue
BACKGROUND: Exposure to adverse perinatal events can impact on the way healthcare professionals (HCPs) provide patient care. The aim of this study was to document the experiences of HCPs following exposure to intrapartum death (IPD), to identify opinions surrounding education and suitable support strategies, and to ascertain if involvement with an IPD had any impact on clinical practice. METHODS: A questionnaire study, with open and closed questions, was developed and set in a tertiary maternity hospital...
February 17, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28204882/comparison-between-vaginal-and-sublingual-misoprostol-50%C3%A2-%C3%A2%C2%B5g-for-cervical-ripening-prior-to-induction-of-labor-randomized-clinical-trial
#5
Andrés Conde, Sebastián Ben, Josefina Tarigo, Santiago Artucio, Virginia Varela, Pamela Grimaldi, Claudio Sosa, Justo Alonso
OBJECTIVE: To compare the effectiveness and safety of sublingual versus vaginal misoprostol on improving the Bishop score after 6 h of administration. METHODS: Randomized clinical trial which includes pregnant women in gestational ages from 32/0 to 41/6, with indication of induction of labor with misoprostol. Bishop score was assessed at the time of induction and 6 h after administration of 50 µg misoprostol. Analysis was made over difference in mean Bishop score of 2 points, using a standard deviation of 2, with 90% power, reaching a 95% confidence interval...
February 16, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28197717/operative-techniques-and-complications-of-extraction-and-transplantation-of-ovarian-tissue-the-erlangen-experience
#6
Matthia W Beckmann, Ralf Dittrich, Laura Lotz, Patricia G Oppelt, Sebastian Findeklee, Thomas Hildebrandt, Katharina Heusinger, Susanne Cupisti, Andreas Müller
PURPOSE: Extracting ovarian tissue before oncologic therapy and transplanting it afterwards are increasingly being used to preserve fertility in women. This study describes standardized and safe operative procedures, with few complications, and reports the resulting ovarian function and pregnancy rates. METHODS: The standardized operative techniques for removing and transplanting ovarian tissue used at the Erlangen center are: for tissue removal, one-third to half of the tissue from one ovary is excised with scissors, without tissue coagulation; for subsequent transplantation, pieces of ovarian tissue are placed in a retroperitoneal pocket without closure of the pocket...
February 15, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28197716/the-effect-of-slow-release-insemination-on-pregnancy-rates-report-of-two-randomized-controlled-pilot-studies-and-meta-analysis
#7
Julian Marschalek, Maximilian Franz, Yael Gonen, Jan-Steffen Kruessel, Amnon Weichselbaum, Lorenz Kuessel, Marie-Louise Trofaier, Johannes Ott
PURPOSE: A modified application technique of intrauterine insemination (IUI) is slow release insemination (SRI), first described by Muharib et al. (Hum Reprod 7(2):227-229, 1992), who postulated higher pregnancy rates with a slow release of spermatozoa for 3 h. METHODS: To investigate this approach, two randomized controlled, cross-over pilot studies were performed from 2004 to 2006 in Israel and Germany to compare SRI with the standard bolus IUI. We aimed to present the results and perform a meta-analysis on available data for SRI...
February 14, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28190105/emt-promoting-transcription-factors-as-prognostic-markers-in-human-breast-cancer
#8
REVIEW
Magdalena Matysiak, Lucyna Kapka-Skrzypczak, Barbara Jodłowska-Jędrych, Marcin Kruszewski
PURPOSE: Breast cancer is one of the most common female cancers. Moreover, despite the progress in medicine, its mortality rate is still very high. Therefore, researchers are constantly looking for new prognostic factors, which may simplify disease diagnosis and optimize the therapy. Metastases are responsible for the majority of deaths caused by breast cancer. Epithelial-mesenchymal transition is one of the mechanisms of metastasis, which is controlled by specific transcription factors...
February 11, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28185073/natural-conception-rates-in-subfertile-couples-following-fertility-awareness-training
#9
P Frank-Herrmann, C Jacobs, E Jenetzky, C Gnoth, C Pyper, S Baur, G Freundl, M Goeckenjan, T Strowitzki
PURPOSE: To analyze cumulative pregnancy rates of subfertile couples after fertility awareness training. METHODS: A prospective observational cohort study followed 187 subfertile women, who had received training in self-observation of the fertile phase of the menstrual cycle with the Sensiplan method, for 8 months. The women, aged 21-47 years, had attempted to become pregnant for 3.5 years on average (range 1-8 years) before study entry. Amenorrhea, known tubal occlusion and severe male factor had been excluded...
February 9, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28180962/cardiotocography-and-the-evolution-into-computerised-cardiotocography-in-the-management-of-intrauterine-growth-restriction
#10
REVIEW
Christina Kouskouti, Kerstin Regner, Julia Knabl, Franz Kainer
Timely recognition and appropriate management of high-risk pregnancies, such as intrauterine growth restriction (IUGR), are of paramount importance for every obstetrician. After the initial screening of IUGR fetuses through sonographic fetometry and Doppler, the focus is shifted to the appropriate monitoring and timing of delivery. This can, especially in cases of early IUGR, become a very difficult task. At this point, cardiotocography (CTG) is introduced as a major tool in the day-to-day monitoring of the antenatal well-being of the IUGR fetus...
February 8, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28176015/crosstalk-considerations-in-studies-evaluating-pelvic-floor-muscles-using-surface-electromyography-in-women-a-scoping-review
#11
REVIEW
Noémie Flury, Irene Koenig, Lorenz Radlinger
PURPOSE: Surface electromyography (sEMG) using intravaginal probes is of widespread use for assessing pelvic floor muscles (PFM) activity in women. Although considered as a reliable method, its validity has been called into question due to the presence of a phenomenon called crosstalk. Crosstalk is described as the recording of sEMG activity originating from neighboring muscles rather than coming exclusively from the muscles being investigated. The purpose of this review was to provide an overview of existing literature about crosstalk during intravaginal surface electromyographic recordings...
February 7, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28176014/breech-presentation-at-term-and-associated-obstetric-risks-factors-a-nationwide-population-based-cohort-study
#12
Georg Macharey, Mika Gissler, Leena Rahkonen, Veli-Matti Ulander, Mervi Väisänen-Tommiska, Mika Nuutila, Seppo Heinonen
PURPOSE: The aim of this study was to estimate whether breech presentation at term was associated with known individual obstetric risk factors for adverse fetal outcome. METHODS: This was a retrospective, nationwide Finnish population-based cohort study. Obstetric risks in all breech and vertex singleton deliveries at term were compared between the years 2005 and 2014. A multivariable logistic regression model was used to determine significant risk factors. RESULTS: The breech presentation rate at term for singleton pregnancies was 2...
February 7, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28176013/impact-of-reproductive-factors-on-breast-cancer-subtypes-in-postmenopausal-women-a-retrospective-single-center-study
#13
Alexandra von Au, Mona Klotzbuecher, Lorenz Uhlmann, Mark Boudewijns, Laura Michel, Markus Wallwiener, Joerg Heil, Michael Golatta, Joachim Rom, Christof Sohn, Andreas Schneeweiss, Florian Schuetz, Christoph Domschke
PURPOSE: Some reproductive factors are well-known general risk factors for breast cancer (BC). On the other hand, BC subtypes also have a high prognostic value. Correlations, however, that link these risk factors to the development of a particular one of the different BC subtypes are still poorly understood. The primary objective of our study was to assess the influence of different reproductive factors (duration of breastfeeding, parity, and age at first childbirth) on pathological BC subtypes...
February 7, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28168656/the-impact-of-mode-of-delivery-on-the-sexual-function-of-primiparous-women-a-prospective-study
#14
Ilker Kahramanoglu, Merve Baktiroglu, Kubra Hamzaoglu, Ozge Kahramanoglu, Fatma Ferda Verit, Oguz Yucel
AIM: The purpose of this study was to evaluate the impact of mode of delivery on the sexual function of women using the Female Sexual Function Index (FSFI). METHODS: This was a prospective study of 452 nulliparous women, comparing their sexual function before and after birth. A Turkish version of the FSFI questionnaire was administered within the first 8 weeks of pregnancy, at 3 and 6 months postpartum in a face-to-face manner and subsequently at the 12th month and 24th month over the telephone...
February 6, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28168655/obesity-risk-awareness-in-women-with-endometrial-cancer
#15
Elizabeth V Connor, Christina A Raker, Melissa A Clark, Ashley R Stuckey
PURPOSE: To assess whether women with endometrial cancer could accurately classify their weight and identify the association between obesity and risk of endometrial, breast, and colon cancers. METHODS: This was an IRB-approved (Project No. 14-0075), survey-based cross-sectional study of women ages 18-80 years with a diagnosis of endometrial cancer. Patients were at least 6 months from hysterectomy and 3 months from chemotherapy or radiation. Statistical analysis was completed using Fisher's exact test, T test, ANOVA, Wilcoxon rank-sum test, or Kruskal-Wallis test...
February 6, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28168653/effects-of-a-hyperandrogenaemic-state-on-the-proliferation-and-decidualization-potential-in-human-endometrial-stromal-cells
#16
Alexander Freis, Tobias Renke, Ulrike Kämmerer, Julia Jauckus, Thomas Strowitzki, Ariane Germeyer
OBJECTIVE: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women, involving hyperandrogenaemia and insulin resistance. Treatment options include dexamethasone, as well as the off-label use of metformin. To evaluate the impact of those drugs on cyclic changes in endometrial development, we tested possible effects of metformin and dexamethasone on endometrial stromal cells decidualisation, proliferation, and gene regulation in a hyperandrogenaemic microenvironment in vitro...
February 6, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28154921/a-phase-1-2a-dose-escalation-safety-pharmacokinetic-and-preliminary-efficacy-study-of-intraperitoneal-administration-of-bc-819-h19-dta-in-subjects-with-recurrent-ovarian-peritoneal-cancer
#17
Ofer Lavie, David Edelman, Tally Levy, Ami Fishman, Ayala Hubert, Yakir Segev, Eli Raveh, Michal Gilon, Avraham Hochberg
BACKGROUND: H19 is a paternally imprinted, oncofetal gene expressed in various embryonic tissues and in 85% of the ovarian tumors. H19-DTA (BC-819) is a DNA plasmid that drives the expression of the diphtheria toxin gene under the regulation of the H19 promoter sequence and therefore is a potential treatment for various tumors that overexpress the H19 gene, among them-ovarian cancer. OBJECTIVE: To assess the safety and efficacy of intra-peritoneal (IP) instillations of H19-DTA (BC-819) plasmid in treating ovarian/peritoneal cancer patients with advanced recurrent disease...
February 3, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28154920/high-grade-serous-ovarian-cancer-the-clone-wars
#18
REVIEW
Aleksander Salomon-Perzyński, Magdalena Salomon-Perzyńska, Bogdan Michalski, Violetta Skrzypulec-Plinta
BACKGROUND: The last 5 years' studies using next-generation sequencing provided evidences that many types of solid tumors present spatial and temporal genetic heterogeneity and are composed of multiple populations of genetically distinct subclones that evolve over time following a pattern of branched evolution. The evolutionary nature of cancer has been proposed as the major contributor to drug resistance and treatment failure. In this review, we present the current state of knowledge about the clonal evolution of high-grade serous ovarian cancer and discuss the challenge that clonal evolution poses for efforts to achieve an optimal cancer control...
February 3, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28138749/the-relationship-between-postmenopausal-women-s-sclerostin-levels-and-their-bone-density-age-body-mass-index-hormonal-status-and-smoking-and-consumption-of-coffee-and-dairy-products
#19
Muberra Namlı Kalem, Ziya Kalem, Nilufer Akgun, Batuhan Bakırarar
PURPOSE: To investigate the relationship between postmenopausal women's sclerostin levels and bone density and the factors that may affect this relationship. MATERIALS AND METHODS: 135 postmenopausal patients' ages, BMIs, hormonal statuses, BMD values, and smoking, and consumption of coffee and dairy products were compared with their sclerostin levels. RESULTS: No statistical relationship was found between sclerostin level and age in the group with osteoporosis (p = 0...
January 31, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28105490/the-effect-of-dexpanthenol-on-experimentally-induced-ovarian-ischaemia-reperfusion-injury-a-biochemical-and-histopathological-evaluation
#20
Oya Soylu Karapinar, Neslihan Pinar, Oğuzhan Özcan, Esin Atik Doğan, Suphi Bayraktar, Hanifi Şahin, Kenan Dolapçioğlu
OBJECTIVE: The aim of this study was to evaluate the effect of two different doses of dexpanthenol (Dxp) onexperimentally induced ovarian ischaemia/reperfusion (I/R) injury ina rat model. STUDY DESIGN: Forty female rats were randomly divided into fivegroups: Group 1: sham operation; Group 2: 3-h ischaemia; Groups 3: 3-h ischaemia, 3-h reperfusion (I/R); Group 4: I/R + 300 mg/kg Dxp intraperitoneally (i.p) Group 5: I /R + 500 mg/kg Dxpi.p. Total anti-oxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), tissue malondialdehyde (MDA) and activities of glutathione peroxidase and catalase were calculated...
January 20, 2017: Archives of Gynecology and Obstetrics
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