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Archives of Gynecology and Obstetrics

Ying Zhang, Shiqian Zhang, Wenqian Huang, Tingting Chen, Hang Yuan, Yumin Zhang
PURPOSE: The aim is to analyze the clinical characteristics of intermediate trophoblastic tumor (ITT). METHODS: 12 cases diagnosed at Qilu Hospital of Shandong University from January 2005 to December 2016 were investigated. Additionally, 50 cases were selected from MEDLINE and CBM databases between January 2010 and December 2016. The clinical data extracted from those aforementioned 62 cases were analyzed. RESULTS: There were 42 cases with placental site trophoblastic tumor (PSTT), 19 cases with epithelioid trophoblastic tumor (ETT), and 1 case with mixed type (PSTT and ETT)...
January 4, 2019: Archives of Gynecology and Obstetrics
S M Hoffmann, D Kappel, A Fech, M D Enderle, M Weiss, M Hahn, S Y Brucker, B Kraemer
PURPOSE: This article investigates the qualities and thermal effects of a novel electrosurgical device (PT) which has been designed by ERBE Elektromedizin GmbH, Germany, for the preparation of critical locations such as in skin-sparing or nipple-sparing techniques and compares it to a standard device (SD) in a porcine ex vivo breast model using an heat map generated by infrared thermography. METHODS: In total, 42 abdominal wall specimens of porcine tissue consisting of the skin and the underlying subcutaneous and muscle layer were alternately dissected using one of the devices and pre-settings...
January 4, 2019: Archives of Gynecology and Obstetrics
Ricardo M Barbosa, Renato T Souza, Carla Silveira, Kleber C Andrade, Cristiane M Almeida, Ana G Bortoleto, Paulo F Oliveira, Jose G Cecatti
PURPOSE: Alterations in renal dimensions may be an early manifestation of deviation from normality, with possible repercussions beyond intrauterine life. The objective of this study was to establish reference curves for fetal kidney dimensions and volume from 14 to 40 weeks of gestation. METHODS: This is a prospective longitudinal study of 115 Brazilian participants in the "WHO multicentre study for the development of growth standards from fetal life to childhood: the fetal component"...
January 4, 2019: Archives of Gynecology and Obstetrics
Theresa Wimmer, Olaf Ortmann, Michael Gerken, Monika Klinkhammer-Schalke, Oliver Koelbl, Elisabeth C Inwald
PURPOSE: According to German S3 guidelines, radiotherapy (RT) is indicated in patients with invasive breast cancer after breast-conserving therapy (BCT). The aim of this analysis was to assess adherence to guidelines, long-term survival, recurrence rates, and recurrence-free survival after adjuvant RT in patients with BCT in daily clinical practice. METHODS: This retrospective cohort study comprised data from the population-based clinical cancer registry of the Tumor Centre Regensburg (Bavaria, Germany)...
January 4, 2019: Archives of Gynecology and Obstetrics
Tanja Burnik Papler, Eda Vrtačnik Bokal, Uršula Prosenc Zmrzljak, Martin Stimpfel, Antonio Simone Laganà, Fabio Ghezzi, Nina Jančar
PURPOSE: The present study aimed to determine clinical IVF parameters and gene expression in cumulus cells (CCs) in obese and normal weighting women after administration of 150 mcg of corifollitropin alfa for controlled ovarian hyperstimulation (COH). METHODS: 150 mcg of corifollitropin alfa and gonadotropin releasing hormone antagonist were used for COH. Analysis of CC gene expression was performed using quantitative real-time PCR. RESULTS: We did not find significant differences in biochemical and clinical pregnancy rates between obese and normal weighting women...
January 4, 2019: Archives of Gynecology and Obstetrics
N Rippinger, J Heinzler, T Bruckner, J Brucker, C Dinkic, J Hoffmann, N Dornhöfer, S Seitz, J Rom, C Sohn, T C Schott, Sarah Schott
PURPOSE: Annual cervical cancer screening is recommended in Germany as a part of the statutory preventive care. Abnormal results can provoke psychological distress and anxiety, compromising women's adherence. Little is known about how a cervical dysplasia impacts adherence follow-up visits and prevention habits over time. To optimize care strategies, this study aims to identify women at risk for nonadherence to follow-up visits after a screening event. METHODS: Between November 2015 and May 2017, participants with an abnormal Pap smear at the Heidelberg and Leipzig University Hospitals received a four-part questionnaire (sociodemographic data, PHQ-D, self-designed fear and prevention habit questions) at the first consultation (T1) and subsequently after 3 (T2) and 6 (T3) months; healthy controls completed the questionnaire at T1...
January 4, 2019: Archives of Gynecology and Obstetrics
Michael von Wolff, Alexandra Kohl Schwartz, Norman Bitterlich, Petra Stute, Monika Fäh
PURPOSE: It is controversial who should be recommended to undergo natural cycle IVF (NC-IVF). Therefore, objective prognostic criteria which are already known at the time of counselling were defined. METHODS: A retrospective observational study was performed with 201 couples (age 34.7 ± 4.1) undergoing 311 NC-IVF treatments with 201 transfers, corresponding to a transfer rate of 65.3%. The first cycle resulting in a transfer of one embryo was further analysed...
January 4, 2019: Archives of Gynecology and Obstetrics
Ahmed M Hussein, Ahmed Kamel, Ayman Raslan, Dina M R Dakhly, Ali Abdelhafeez, Mohamed Nabil, Mohamed Momtaz
PURPOSE: To evaluate the effect of a modified type II radical hysterectomy on maternal morbidities and mortality in cases with abnormally invasive placenta (AIP). METHODS: 63 cases with AIP were managed at one of the largest referral centers in Egypt in a prospective study design. This technique entails devascularization of the uterus laterally on both sides and to clamp the uterus at the lowest possible point just below the level of the placenta while sparing the ureters...
January 4, 2019: Archives of Gynecology and Obstetrics
Katrina Mark, Anja Frost, Heather Hussey, Micael Lopez-Acevedo, Anne E Burke, Jill Edwardson, Opey Solaru, Patti Gravitt
PURPOSE: To determine rates and factors associated with regression of cervical intraepithelial neoplasia (CIN) 2 + between colposcopic biopsy and therapeutic excisional procedure in standard practice. METHODS: A retrospective chart review was performed for women undergoing a cervical excisional procedure for CIN 2 + at clinics at three academic institutions over a 3-year period. Cytology, histology, patient age and time-to-excision were analyzed to determine factors influencing rates of regression...
January 4, 2019: Archives of Gynecology and Obstetrics
Pietro Gambadauro
No abstract text is available yet for this article.
January 4, 2019: Archives of Gynecology and Obstetrics
Saskia Spaich, Sophie Krickeberg, Svetlana Hetjens, Frederik Wenz, Axel Gerhardt, Marc Sütterlin
PURPOSE: Patient comfort and preference have steadily gained attention in radio-oncologic treatment of breast cancer. Therefore, the purpose of this investigation was to further explore patient preferences in choosing between intraoperative radiotherapy (IORT) and external beam radiotherapy (EBRT). METHODS: We prospectively analysed data of 101 women, who were candidates for breast-conserving surgery with adjuvant radiotherapy. A two-part video was shown to patients: an educational section about EBRT/IORT, followed by a preference elicitation section focusing on additional accepted risk (AAR) of recurrence after either treatment...
January 4, 2019: Archives of Gynecology and Obstetrics
Ferenc Zoltan Takacs, Julia Caroline Radosa, Florian Bochen, Ingolf Juhasz-Böss, Erich-Franz Solomayer, Rainer M Bohle, Georg-Peter Breitbach, Bernard Schick, Maximilian Linxweiler
PURPOSE: The aim of this study was to analyze the diagnostic performance of a newly established immunocytochemical dual-staining protocol for the simultaneous expression of SEC62 and Ki67 in vulvar liquid-based cytology specimens for the identification of vulvar intraepithelial neoplasia (VIN) and vulvar cancer. In addition, we investigated the p16/Ki67 dual stain, which has already been established in cervical cytology. MATERIALS AND METHODS: For this pilot study, residual material from liquid-based cytology was collected retrospectively from 45 women...
January 4, 2019: Archives of Gynecology and Obstetrics
Ioannis Tsakiridis, Alexandra Arvanitaki, Elias Zintzaras
PURPOSE: The majority of epidemiological studies in preeclampsia are observational and the overview of these studies is expressed by systematic reviews (SRs). The aim of this study was to evaluate the reporting quality of published SRs of observational studies (OS) in preeclampsia based on Meta-analysis of Observational Studies in Epidemiology (MOOSE) statement. METHODS: PubMed and Cochrane databases were searched for SRs of OS in preeclampsia published from 1st January 2011 through 10th December 2017...
January 4, 2019: Archives of Gynecology and Obstetrics
Xiaqin Huo, Liang Yao, Xue Han, Wen Li, Junjuan Liu, Lijun Zhou, Yuanfeng Gou, Kehu Yang, Huiling Liu
PURPOSE: The association between hysterectomy for benign gynecologic disease and ovarian cancer risk was controversial. Thus, we perform a systematic review and meta-analysis to evaluate the effect of hysterectomy and ovarian cancer risk. METHODS: PubMed, Cochrane Library, and Embase were searched from 2000 toJanuary 2018. A random-effect model was used to obtain the summary odds risks (ORs) and 95% confidence intervals (CIs). RESULTS: A total of 18 case-control studies were included in the meta-analysis...
January 4, 2019: Archives of Gynecology and Obstetrics
Maria Lagerstedt, R Huotari-Orava, R Nyberg, L Nissinen, M Farshchian, S-L Laasanen, E Snellman, J U Mäenpää, V-M Kähäri
PURPOSE: The two main etiological factors for vulvar squamous cell carcinoma (vSCC) are the vulvar dermatosis lichen sclerosus (LS) and high-risk human papillomavirus (hrHPV). Serpin A1 (α1-antitrypsin) is a serine protease inhibitor, which plays a role in the tumorigenesis of various cancer types. The aim of the study was to evaluate the expressions of Serpin A1 in LS, premalignant vulvar lesions, and vSCC using immunohistochemistry (IHC) and serum analysis, and to compare Serpin A1 stainings to the tumor markers p53 and p16...
January 4, 2019: Archives of Gynecology and Obstetrics
Shan Zong, Xiaoxia Liu, Na Zhou, Ying Yue
PURPOSE: We aimed to seek the crucial genes or microRNAs (miRNA) correlated with the cervical cancer development. METHODS: The miRNA profiling GSE30656 and gene expression profiling GSE63514 were obtained from Gene Expression Omnibus database. Differentially expressed microRNAs (DEMiRs) and differentially expressed genes (DEGs) were screened. Then target genes of DEMiRs were obtained and matched with DEGs to obtain interaction pairs between DEMiRs and DEGs. Gene Ontology-biological process and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted for DEGs and DEMiRs in the DEMiRs-DEGs pairs...
January 4, 2019: Archives of Gynecology and Obstetrics
Ferenc Zoltan Takacs, Julia Caroline Radosa, Christoph Gerlinger, Sebastian Findeklee, Ingolf Juhasz-Böss, Erich-Franz Solomayer, Amr Hamza
PURPOSE: We address the impact of applying loop electrosurgical excision procedure (LEEP) under direct colposcopic vision teaching to our undergraduates using a self-developed simulation model and a standardized assessment to evaluate the progress of learning. METHODS: The undergraduate teaching module was composed of a theoretical course on cervical dysplasia, colposcopy, electrosurgery and excisional procedures of the uterine cervix. This was followed by hands-on practical rounds...
January 4, 2019: Archives of Gynecology and Obstetrics
Yihua Lin, Puyu Yang, Yanrong Chen, Jinliang Zhu, Xinyu Zhang, Caihong Ma
PURPOSE: Decreased oocyte maturation rate (OMR) is associated with worse clinical outcomes in IVF/ICSI cycles. The clinical features inducing decreased OMR remain unknown. The study is designed to explore the factors influencing the incidence of decreased OMR and its effects on clinical outcomes. METHODS: This is a retrospective case-control study analyzing data from 20,939 ICSI cycles in a reproductive center of university affiliated hospital from January 2015 to December 2017...
January 4, 2019: Archives of Gynecology and Obstetrics
Dominik Bieg, Daniel Sypniewski, Ewa Nowak, Ilona Bednarek
PURPOSE: Assessment of miR-424-3p mimic capability to sensitize SK-OV-3 and TOV-21G ovarian cancer cells to cisplatin by decreasing the expression of galectin-3, which is an anti-apoptotic protein overexpressed in ovarian cancer and associated with resistance to chemotherapy. METHODS: We performed a reverse transfection of miR-424-3p mimic into SK-OV-3 and TOV-21G ovarian cancer cells, followed by Real Time™ RT-PCR analysis of the expression of miR-424-3p and galectin-3 mRNA as well as ELISA assay for galectin-3 protein level...
December 26, 2018: Archives of Gynecology and Obstetrics
Natalia Prodan, Julia Breisch, Markus Hoopmann, Harald Abele, Philipp Wagner, Karl Oliver Kagan
OBJECTIVE: To compare several strategies for second trimester labor induction for termination of pregnancy (TOP) using misoprostol and mifepristone and to determine which one is more effective in accelerating the time to delivery. METHOD: This was a retrospective study in which pregnancies that underwent second and third trimester TOP due to fetal anomalies between 2007 and 2017 were classified into a group that received misoprostol alone, a group that received mifepristone followed by misoprostol on the same day, one where misoprostol was given 1 day after mifepristone and one where the medications were administered 2 days apart...
December 21, 2018: Archives of Gynecology and Obstetrics
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