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Neurotoxicology and Teratology

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https://www.readbyqxmd.com/read/28223149/long-term-behavioral-change-as-a-result-of-acute-ethanol-exposure-in-zebrafish-evidence-for-a-role-for-sonic-hedgehog-but-not-retinoic-acid-signaling
#1
Derek Burton, Chengjin Zhang, Oswald Boa-Amponsem, Shanta Mackinnon, Gregory J Cole
BACKGROUND: Developmental exposure to ethanol is recognized to produce long-term neurobehavioral impairment in multiple animal models. However, the molecular mechanisms underlying these deficits remain poorly understood. The present study was undertaken to ascertain whether two well-characterized targets of prenatal alcohol exposure, sonic hedgehog (Shh) and retinoic acid (RA), that induce the hallmark morphological phenotypes of fetal alcohol spectrum disorders (FASD), are involved in the generation of behavioral alterations as a result of alcohol exposure...
February 18, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28212938/the-combined-effects-of-3-4-methylenedioxymethamphetamine-mdma-and-selected-substituted-methcathinones-on-measures-of-neurotoxicity
#2
Nicholas B Miner, James P O'Callaghan, Tamara J Phillips, Aaron Janowsky
The rise in popularity of substituted methcathinones (aka "bath salts") has increased the focus on their neurotoxic effects. Two commonly abused methcathinones, 3,4-methylenedioxymethcathinone (methylone, MDMC) and 3,4-methylenedioxypyrovalerone (MDPV), are often concomitantly ingested with the illicit drug 3,4-methylenedioxymethamphetamine (MDMA). To examine potential neurotoxic effects of these drug combinations, C57BL/6J mice were administered 4 i.p. injection of the drugs, at 2h intervals, either singularly: MDMA 15 or 30mg/kg, methylone 20mg/kg, MDPV 1mg/kg; or in combination: methylone/MDMA 20/15mg/kg, MDPV/MDMA 1/15mg/kg...
February 14, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28188837/response-to-golub-herr-and-sobin
#3
LETTER
Lori L Driscoll
No abstract text is available yet for this article.
February 7, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28179122/introduction-to-the-special-issue-developmental-neurotoxicity-associated-with-pediatric-general-anesthesia-preclinical-findings
#4
EDITORIAL
Vesna Jevtovic-Todorovic, Merle G Paule
No abstract text is available yet for this article.
February 4, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28163169/does-maoa-increase-susceptibility-to-prenatal-stress-in-young-children
#5
Suena H Massey, Amalia E Hatcher, Caron A C Clark, James L Burns, Daniel S Pine, Andrew D Skol, Daniel K Mroczek, Kimberly A Espy, David Goldman, Edwin Cook, Lauren S Wakschlag
BACKGROUND: We previously demonstrated a gene-by-prenatal-environment interaction whereby the monoamine oxidase A gene (MAOA) modified the impact of prenatal tobacco exposure (PTE) on adolescent disruptive behavior (DB), with the MAOA risk genotype varying by sex. We extend this work by examining whether this mechanism is evident with another common adversity, prenatal stress exposure (PSE), and whether sex differences are present earlier in development in closer proximity to exposure...
February 3, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28131877/carbon-monoxide-incompletely-prevents-isoflurane-induced-defects-in-murine-neurodevelopment
#6
Li Wang, Aili Wang, William W Supplee, Kayla Koffler, Ying Cheng, Zenaide M N Quezado, Richard J Levy
BACKGROUND: Commonly used anesthetics have been shown to disrupt neurodevelopment in preclinical models.It has been proposed that such anesthesia-induced neurotoxicity is mediated by apoptotic neurodegeneration in the immature brain.Low dose carbon monoxide (CO) exerts cytoprotective properties and we have previously demonstrated that CO inhibits isoflurane-induced apoptosis in the developing murine brain.Here we utilized anti-apoptotic concentrations of CO to delineate the role of apoptotic neurodegeneration in anesthesia-induced neurotoxicity by assessing the effect of CO on isoflurane-induced defects in neurodevelopment...
January 25, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28109771/assessment-of-learning-memory-and-attention-in-developmental-neurotoxicology-regulatory-testing-commentary-on-essentiality-of-cognitive-assessment-for-protecting-child-health
#7
Charles V Vorhees
This commentary is in response to the remarks of Drs. Christina Sobin, Mari Golub, and David Herr on the Special Issue of this Journal entitled "Assessment of Learning, Memory, and Attention in Developmental Neurotoxicology Regulatory Testing." I endorse the views expressed by Drs. Sobin, Golub, and Herr and add some discussion on a recent Organization on Economic Cooperation and Development (OECD) guideline, the Extended One Generation Reproductive Toxicology Guideline (OECD 446), in which testing for higher cognitive function (learning and memory) has been eliminated...
January 18, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28089843/early-chronic-low-level-pb-exposure-alters-global-exploratory-behaviors-but-does-not-impair-spatial-and-object-memory-retrieval-in-an-object-in-place-task-in-pre-adolescent-c57bl-6j-mice
#8
Christina Sobin, Mayra Gisel Flores-Montoya, Juan Manuel Alvarez
The mechanisms by which early chronic low-level lead (Pb) exposure disrupts the developing brain are not yet understood. Rodent models have provided promising results however behavioral tests sensitive to effects at lowest levels of exposure during development are needed. Preadolescent animals (N=52) exposed to low and higher levels of Pb via lactation from birth to PND 28 completed the Object-in-Place Task of visual spatial and visual object memory retrieval (at PND 28). Generalized linear mixed models were used, controlling for sex and litter as a random effect...
January 12, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28065636/neuroprotection-and-neurotoxicity-in-the-developing-brain-an-update-on-the-effects-of-dexmedetomidine-and-xenon
#9
Azeem Alam, Ka Chun Suen, Zac Hana, Robert D Sanders, Mervyn Maze, Daqing Ma
Growing and consistent preclinical evidence, combined with early clinical epidemiological observations, suggest potentially neurotoxic effects of commonly used anesthetic agents in the developing brain. This has prompted the FDA to issue a safety warning for all sedatives and anesthetics approved for use in children under three years of age. Recent studies have identified dexmedetomidine, the potent α2-adrenoceptor agonist, and xenon, the noble gas, as effective anesthetic adjuvants that are both less neurotoxic to the developing brain, and also possess neuroprotective properties in neonatal and other settings of acute ongoing neurologic injury...
January 5, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28043908/cognitive-neuroscience-and-developmental-neurotoxicity-testing
#10
LETTER
Mari S Golub
No abstract text is available yet for this article.
December 30, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28039052/a-holistic-approach-to-anesthesia-induced-neurotoxicity-and-its-implications-for-future-mechanistic-studies
#11
Christine N Zanghi, Vesna Jevtovic-Todorovic
The year 2016 marked the 15th anniversary since anesthesia-induced developmental neurotoxicity and its resulting cognitive dysfunction were first described. Since that time, multiple scientific studies have supported these original findings and investigated possible mechanisms behind anesthesia-induced neurotoxicity. This paper reviews the existing mechanistic literature on anesthesia-induced neurotoxicity in the context of a holistic approach that emphasizes the importance of both neuronal and non-neuronal cells during early postnatal development...
December 28, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27979759/correspondence-assessment-of-learning-memory-and-attention-in-developmental-neurotoxicology
#12
LETTER
C Sobin
No abstract text is available yet for this article.
December 12, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27939643/commentary-on-topic-should-all-tests-of-cognitive-function-learning-memory-attention-be-eliminated-from-the-required-protocols-for-developmental-neurotoxicity-testing
#13
LETTER
David W Herr
The attached manuscript by Dr. Herr is a Commentary on Topic: Should All Tests of Cognitive Function - Learning, Memory, Attention - be Eliminated From the Required Protocols for Developmental Neurotoxicity Testing?
December 8, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27919701/evaluation-of-the-neurotoxic-effects-of-chronic-embryonic-exposure-with-inorganic-mercury-on-motor-and-anxiety-like-responses-in-zebrafish-danio-rerio-larvae
#14
Noraini Abu Bakar, Nurul Syafida Asma' Mohd Sata, Nurul Farhana Ramlan, Wan Norhamidah Wan Ibrahim, Syaizwan Zahmir Zulkifli, Che Azurahanim Che Abdullah, Syahida Ahmad, Mohammad Noor Azmai Amal
Chronic exposure to mercury (Hg) can lead to cumulative impairments in motor and cognitive functions including alteration in anxiety responses. Although several risk factors have been identified in recent year, little is known about the environmental factors that either due exposure toward low level of inorganic mercury that may led to the developmental disorders. The present study investigated the effects of embryonic exposure of mercury chloride on motor function and anxiety-like behavior. The embryo exposed to 6 different concentrations of HgCl2 (7...
December 3, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27919700/exposure-to-sevoflurane-anesthesia-during-development-does-not-impair-aspects-of-attention-during-adulthood-in-rats
#15
Kathy L Murphy, Jill McGaughy, Paula L Croxson, Mark G Baxter
Exposure to general anesthetic agents during development has been associated with neurotoxicity and long-term behavioral impairments in rodents and non-human primates. The phenotype of anesthetic-induced cognitive impairment has a robust learning and memory component, however less is known about other psychological domains. Data from retrospective human patient studies suggest that children undergoing multiple procedures requiring general anesthesia are at increased risk of attention deficit hyperactivity disorder...
December 2, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27916716/effects-of-a-non-competitive-n-methyl-d-aspartate-nmda-antagonist-tiletamine-in-adult-zebrafish
#16
Tatiana O Kolesnikova, Sergey L Khatsko, Vadim A Shevyrin, Yuri Yu Morzherin, Allan V Kalueff
Tiletamine is a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist chemically related to ketamine and phencyclidine. A common veterinary anesthetic drug, tiletamine is currently a Schedule III controlled substance in USA. This compound exerts sedative effects in humans and animals, also having an abuse potential, toxicity and dissociative hallucinogenic properties clinically. However, the neurotropic profile of tiletamine remains poorly understood, necessitating novel models and in-vivo screens, including non-mammalian species...
December 2, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27989697/developmental-benzo-a-pyrene-b-a-p-exposure-impacts-larval-behavior-and-impairs-adult-learning-in-zebrafish
#17
Andrea L Knecht, Lisa Truong, Michael T Simonich, Robert L Tanguay
Polycyclic aromatic hydrocarbons (PAHs) are produced from incomplete combustion of organic materials or fossil fuels, and are present in crude oil and coal; therefore, they are ubiquitous environmental contaminants present in urban air, dust, soil, and water. It is widely recognized that PAHs pose risks to human health, especially for the developing fetus and infant where PAH exposures have been linked to in-utero mortality, cardiovascular effects, and lower intelligence. Using the zebrafish model, we evaluated the developmental toxicity of benzo[a]pyrene (B[a]P)...
January 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27989696/methyl-mercury-exposure-and-neurodevelopmental-outcomes-in-the-seychelles-child-development-study-main-cohort-at-age-22-and-24years
#18
Edwin van Wijngaarden, Sally W Thurston, Gary J Myers, Donald Harrington, Deborah A Cory-Slechta, J J Strain, Gene E Watson, Grazyna Zareba, Tanzy Love, Juliette Henderson, Conrad F Shamlaye, Philip W Davidson
BACKGROUND: All fish contain methyl mercury (MeHg), a known neurotoxicant at adequate dosage. There is still substantial scientific uncertainty about the consequences, if any, of mothers consuming fish with naturally-acquired levels of MeHg contamination. In 1989-1990, we recruited the Main Cohort of the Seychelles Child Development Study to assess the potential developmental effects of prenatal MeHg exposure. We report here on associations with neurodevelopmental outcomes obtained at 22 and 24years of age...
January 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27756629/developmental-manganese-neurotoxicity-in-rats-cognitive-deficits-in-allocentric-and-egocentric-learning-and-memory
#19
Robyn M Amos-Kroohs, Laurie L Davenport, Nina Atanasova, Zuhair I Abdulla, Matthew R Skelton, Charles V Vorhees, Michael T Williams
Manganese (Mn) is an essential element but neurotoxic at higher exposure levels. The effects of Mn overexposure (MnOE) on hippocampal and striatal-dependent learning and memory in rats were tested in combination with iron deficiency (FeD) and developmental stress that often co-occur with MnOE. Moderate FeD affects up to 15% of U.S. children and developmental stress is common in lower socio-economic areas where MnOE occurs. Pregnant Sprague-Dawley rats and their litters were housed in cages with or without (barren cage (BAR)) standard bedding from embryonic day (E)7 to postnatal day (P)28...
January 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27751817/prenatal-arsenic-exposure-alters-rest-nrsf-and-microrna-regulators-of-embryonic-neural-stem-cell-fate-in-a-sex-dependent-manner
#20
Christina R Tyler, Matthew T Labrecque, Elizabeth R Solomon, Xun Guo, Andrea M Allan
Exposure to arsenic, a common environmental toxin found in drinking water, leads to a host of neurological pathologies. We have previously demonstrated that developmental exposure to a low level of arsenic (50ppb) alters epigenetic processes that underlie deficits in adult hippocampal neurogenesis leading to aberrant behavior. It is unclear if arsenic impacts the programming and regulation of embryonic neurogenesis during development when exposure occurs. The master negative regulator of neural-lineage, REST/NRSF, controls the precise timing of fate specification and differentiation of neural stem cells (NSCs)...
January 2017: Neurotoxicology and Teratology
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