Isamu Noguchi, Maeda Hitoshi, Kazuki Kobayashi, Taisei Nagasaki, Hiromasa Kato, Hiroki Yanagisawa, Naoki Wada, Gai Kanazawa, Tsubasa Kaji, Hiromi Sakai, Shin Fujimaki, Yusuke Ono, Kazuaki Taguchi, Victor Tuan Giam Chuang, Junji Saruwatari, Masaki Otagiri, Hiroshi Watanabe, Toru Maruyama
Sarcopenia is characterized by loss of muscle strength and muscle mass with aging. The growing number of sarcopenia patients as a result of the aging population has no viable treatment. Exercise maintains muscle strength and mass by increasing peroxisome growth factor activating receptor γ-conjugating factor-1α (PGC-1α) and Akt signaling in skeletal muscle. The present study focused on the carbon monoxide (CO), endogenous activator of PGC-1α and Akt, and investigated the therapeutic potential of CO-loaded red blood cells (CO-RBCs), which is bioinspired from in vivo CO delivery system, as an exercise mimetic for the treatment of sarcopenia...
April 22, 2024: Free Radical Biology & Medicine