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Acta Oncologica

Ahmet Emre Eskazan
No abstract text is available yet for this article.
August 14, 2018: Acta Oncologica
Ritesh Sachdev, Shalini Goel, Neha Rastogi, Satya Prakash Yadav, Ishani Mohapatra
No abstract text is available yet for this article.
August 13, 2018: Acta Oncologica
Kristian H Jensen, Gitte Persson, Lone Storgaard, Birgitte B Nielsen, Berit W Pedersen, Lisa L Maroun, Alwin Huitema, Mette Pøhl
No abstract text is available yet for this article.
August 11, 2018: Acta Oncologica
Anne Sofie Brems-Eskildsen, Kristina Bak Kristoffersen, Søren Linnet, Tamás Lörincz, Sven Tyge Langkjer
No abstract text is available yet for this article.
August 11, 2018: Acta Oncologica
Kenneth Wikström, Ulf Isacsson, Kristina Nilsson, Anders Ahnesjö
BACKGROUND: Deep inspiration breath hold (DIBH) for radiotherapy of left-sided breast cancer patients can effectively move the heart away from the target and reduce the heart dose compared to treatments in free breathing. This study aims to investigate the positional reproducibility of heart edge (HE) and thoracic wall (TW) during repeated DIBHs. MATERIAL AND METHODS: At three occasions, 11 left-sided breast cancer patients were CT imaged during 6 minutes of repeated DIBHs with 60 cine CT series...
August 3, 2018: Acta Oncologica
Are Kristensen, Tora Skeidsvoll Solheim, Øystein Fløtten, Bjørn Henning Grønberg
BACKGROUND: Many patients experience toxicity from chemotherapy that may negatively impact their health-related quality of life (HRQoL), but side effects often go undetected by health care personnel. Our aim was to investigate whether hematologic toxicity (HT) was associated with HRQoL impairment, and, consequently, if blood counts could be used to identify patients with the highest need for supportive care during chemotherapy. MATERIAL AND METHODS: Data from two phase III trials of first-line chemotherapy in advanced non-small-cell lung cancer (NSCLC) were analyzed (n = 873)...
August 3, 2018: Acta Oncologica
Ruben T H M Larue, Remy Klaassen, Arthur Jochems, Ralph T H Leijenaar, Maarten C C M Hulshof, Mark I van Berge Henegouwen, Wendy M J Schreurs, Meindert N Sosef, Wouter van Elmpt, Hanneke W M van Laarhoven, Philippe Lambin
BACKGROUND: Radiomic features retrieved from standard CT-images have shown prognostic power in several tumor sites. In this study, we investigated the prognostic value of pretreatment CT radiomic features to predict overall survival of esophageal cancer patients after chemoradiotherapy. MATERIAL AND METHODS: Two datasets of independent centers were analyzed, consisting of esophageal cancer patients treated with concurrent chemotherapy (Carboplatin/Paclitaxel) and 41...
August 1, 2018: Acta Oncologica
Thiru Prasanna, Christos S Karapetis, David Roder, Jeanne Tie, Robert Padbury, Timothy Price, Rachel Wong, Jeremy Shapiro, Louise Nott, Margaret Lee, Yu Jo Chua, Paul Craft, Cynthia Piantadosi, Michael Sorich, Peter Gibbs, Desmond Yip
BACKGROUND: Pattern of spread in patients with metastatic colorectal cancer (mCRC) is variable and may reflect different biology in subsets of patients. This is a retrospective study to explore the outcome of patients with mCRC based on their site of metastasis at diagnosis and to explore the association between tumor characteristics [KRAS/RAS, BRAF, mismatch repair (MMR) status, site of primary] and the site of metastasis. METHODS: Patients from two Australian databases were divided into six groups based on site of metastasis at time of diagnosis of metastatic disease; lung-only, liver-only, lymph node-only or any patients with brain, bone or peritoneal metastases...
July 23, 2018: Acta Oncologica
Curtiland Deville, Akansha Jain, Wei-Ting Hwang, Kristina D Woodhouse, Stefan Both, Shiyu Wang, Peter E Gabriel, John P Christodouleas, Justin Bekelman, Zelig Tochner, Neha Vapiwala
PURPOSE: To report acute and late genitourinary (GU) and gastrointestinal (GI) toxicities associated with post-prostatectomy proton therapy (PT). METHODS: The first 100 consecutive patients from 2010 to 2016 were retrospectively assessed. Baseline characteristics, prospectively graded CTCAE v4.0 toxicities, and patient-reported outcomes were reported. Late outcomes were reported for 79 patients with 3 months minimum follow up. Toxicity-free survival Kaplan-Meier curves were estimated...
July 20, 2018: Acta Oncologica
Alexandra K Rzepecki, Jenny Wang, Alexandra Urman, Bijal Amin, Beth McLellan
No abstract text is available yet for this article.
July 17, 2018: Acta Oncologica
Niels Lyhne Christensen, Susanne Oksbjerg Dalton, Anders Mellemgaard, Jane Christensen, Anne Mette Tranberg Kejs, Torben Riis Rasmussen
BACKGROUND: There is paucity of evidence regarding the optimal follow-up (FU) regimen for lung cancer. Consequently, FU is organized differently across countries. The Danish FU regimen has short FU intervals with a computed tomography (CT) scan of the chest and upper abdomen every three months in the early phase (first 2 years), then every six months in the late phase of FU (3rd, 5th year). Characterizing recurrences missed by the FU program in terms of site, tumor histology, department, and phase of FU, could improve the FU program...
July 16, 2018: Acta Oncologica
Eun Hee Jeang, Youngmoon Goh, Kwan Ho Cho, Soonki Min, Sang Hyoun Choi, Hojin Jeong, Kwanghyun Jo, Nuri Lee, Sanghyeon Song, Se Byeong Lee, Dongho Shin, Yeon-Joo Kim, Joo-Young Kim, Dae Yong Kim, Ui-Jung Hwang, Young Kyung Lim
BACKGROUND: The aim of the present study was to verify the dosimetric accuracy of two-dimensional (2D) in vivo rectal dosimetry using an endorectal balloon (ERB) with unfoldable EBT3 films for high-dose-rate (HDR) brachytherapy for cervical cancer. The clinical applicability of the technique was discussed. MATERIAL AND METHODS: ERB inflation makes the EBT3 films unrolled, whereas its deflation makes them rolled. Patient-specific quality assurance (pQA) tests were performed in 20 patient plans using an Ir-192 remote afterloading system and a water-filled cervical phantom with the ERB...
July 13, 2018: Acta Oncologica
Sofie Walming, Dan Asplund, Mattias Block, David Bock, Elisabeth Gonzalez, Carina Rosander, Jacob Rosenberg, Eva Angenete
AIM: Patients with rectal cancer may undergo treatment such as surgery and (chemo)radiotherapy. Before treatment, patients are informed of different options and possible side-effects. The aim of the study was to evaluate the patients' experience of communication with healthcare personnel at time of diagnosis and after one year. METHOD: A total of 1085 patients from Denmark and Sweden were included. They answered a detailed questionnaire at diagnosis and at the one year follow-up...
July 10, 2018: Acta Oncologica
Linda Rossi, Abdul Wahab Sharfo, Shafak Aluwini, Maarten Dirkx, Sebastiaan Breedveld, Ben Heijmen
BACKGROUND: For conventional radiotherapy treatment units, automated planning can significantly improve plan quality. For robotic radiosurgery, systems for automatic generation of clinically deliverable plans do not yet exist. For prostate stereotactic body radiation therapy (SBRT), few studies have systematically compared VMAT with robotic treatment. MATERIAL AND METHODS: The multi-criteria autoplanning optimizer, developed at our institute, was coupled to the commercial treatment planning system of our robotic treatment unit, for fully automated generation of clinically deliverable plans (autoROBOT)...
July 2, 2018: Acta Oncologica
Yvonka van Wijk, Ben G L Vanneste, Arthur Jochems, Sean Walsh, Cary J Oberije, Michael Pinkawa, Bram L T Ramaekers, Ana Vega, Philippe Lambin
INTRODUCTION: Previous studies revealed that dose escalated radiotherapy for prostate cancer patients leads to higher tumor control probabilities (TCP) but also to higher rectal toxicities. An isotoxic model was developed to maximize the given dose while controlling the toxicity level. This was applied to analyze the effect of an implantable rectum spacer (IRS) and extended with a genetic test of normal tissue radio-sensitivity. A virtual IRS (V-IRS) was tested using this method. We hypothesized that the patients with increased risk of toxicity would benefit more from an IRS...
June 28, 2018: Acta Oncologica
Lena Sharp, Bodil Westman, Anna Olofsson, Arja Leppänen, Roger Henriksson
BACKGROUND: Sweden's national cancer strategy points out several areas of cancer care that need improvements. Among them the need for supportive care resources to be accessible through the entire cancer trajectory and the reduction of socioeconomic inequalities. The aim of this study was to compare the patient-reported access to supportive care in the Stockholm-Gotland region between patients diagnosed in 2014 and 2016. The aim was also to describe how socioeconomic and other demographic factors impact access to supportive care...
June 27, 2018: Acta Oncologica
Tim A Labeur, David W G Ten Cate, R Bart Takkenberg, Hicham Azahaf, Martijn G H van Oijen, Otto M van Delden, Robert A de Man, Jeroen L A van Vugt, Jan N M IJzermans, Ferry A L M Eskens, Heinz-Josef Klümpen
BACKGROUND: Upon FDA/EMEA registration for hepatocellular carcinoma (HCC), sorafenib received a broader therapeutic indication than the eligibility criteria of the landmark SHARP trial. This allowed treatment of SHARP non-eligible patients in daily clinical practice. AIM: To assess sorafenib efficacy and safety in SHARP eligible and non-eligible patients, and determine the validity of the current therapeutic indication as described by the FDA/EMEA. PATIENTS AND METHODS: Consecutive patients treated with sorafenib for advanced HCC at two Dutch tertiary referral centers between 2007 and 2016 were analyzed retrospectively...
June 26, 2018: Acta Oncologica
L Cillessen, M P J Schellekens, M O M Van de Ven, A R T Donders, F R Compen, E M Bisseling, M L Van der Lee, A E M Speckens
BACKGROUND: Group face-to-face and individual internet-based mindfulness-based cognitive therapy (MBCT and eMBCT) have been demonstrated to reduce psychological distress for distressed cancer patients in a randomized controlled trial (RCT). This study focused on the long-term effects of this RCT during the nine-month follow-up period, and on possible predictors, moderators and working mechanisms. METHODS: Distressed cancer patients (n = 245) were randomized to MBCT or eMBCT...
June 22, 2018: Acta Oncologica
Per Lindnér, Erik Holmberg, Lo Hafström
BACKGROUND: Gallbladder cancer (GBC) has an extremely poor outcome. The aim of this study was to examine trends in GBC incidence, treatment and overall survival in a complete population of affected persons in a well-defined region in Sweden in 2000-2014. MATERIAL AND METHODS: Altogether 546 individuals with GBC were identified at Sweden's Regional Cancer Centre West. Subjects were grouped into three 5-year periods (Period A: 2000-2004, Period B: 2005-2009 and Period C: 2010-2014) and the survival, diagnosis, staging, grading and treatment for each period were investigated...
June 22, 2018: Acta Oncologica
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