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Acta Oncologica

Thomas B Piper, Lars N Jørgensen, Jesper Olsen, Knud T Nielsen, Gerard Davis, Julia S Johansen, Ib Jarle Christensen, Hans J Nielsen
BACKGROUND: Blood-based, cancer-associated biomarkers may detect subjects at risk of having neoplastic diseases. The aim of the present study was to evaluate whether elevated serological protein biomarker levels may identify adenoma patients, who are at increased risk of being diagnosed with subsequent primary malignancy. METHODS: Levels of CEA, CA19-9, TIMP-1 and YKL-40 were determined in blood samples collected prior to diagnostic bowel endoscopy due to symptoms of colorectal neoplasia...
December 7, 2018: Acta Oncologica
Mia W Steffenssen, Issam Al-Najami, Erik Zimmermann-Nielsen, Gunnar Baatrup
OBJECTIVE: This prospective pilot study assessed the feasibility of electronic email-based questionnaires about patient-reported complications after colonoscopy. MATERIAL AND METHODS: A newly internally validated questionnaire on patient-reported complications related to colonoscopy was conducted as an online survey. RESULTS: Out of 200 patients (mean age 65 years), 83% completed the first questionnaire immediately after the procedure, 77% completed the second follow-up questionnaire after 24 h at home, and 70% the third one after 30 d...
December 7, 2018: Acta Oncologica
F Guerreiro, E Seravalli, G O Janssens, M M van den Heuvel-Eibrink, J J W Lagendijk, B W Raaymakers
PURPOSE/OBJECTIVE: Flank irradiation for Wilms' tumor (WT) is currently performed at our institute using a cone-beam computed tomography-guided volumetric modulated arc (VMATCBCT ) workflow. By adding real-time magnetic resonance imaging (MRI) guidance to the treatment, safety margins could be reduced. The study purpose was to quantify the potential reduction of the planning target volume (PTV) margin and its dosimetric impact when using an MRI-guided intensity modulated radiation therapy (IMRTMRI ) workflow compared to the VMATCBCT workflow...
December 7, 2018: Acta Oncologica
A L Versteeg, J Hes, J M van der Velden, W Eppinga, N Kasperts, H M Verkooijen, M van Vulpen, F C Oner, E Seravalli, J J Verlaan
INTRODUCTION: Decreasing the radiation dose in the surgical area is important to lower the risk of wound complications when surgery and radiotherapy are combined for the treatment of spinal metastases. The purpose of this study was to compare the radiation dose in the surgical area for spinal metastases between single fraction external beam radiotherapy (EBRT), single fraction stereotactic body radiotherapy (SBRT) and single fraction SBRT with active sparing (SBRT-AS) of the posterior surgical area...
December 4, 2018: Acta Oncologica
Anna E Nordenskjöld, Helena Fohlin, Lars G Arnesson, Zakaria Einbeigi, Erik Holmberg, Per Albertsson, Per Karlsson
BACKGROUND: During the recent decades, breast cancer survival has gradually improved but there is limited knowledge on the improvement in population-based studies of patients diagnosed with different stages of the disease and in different age groups. PATIENTS AND METHODS: In two Swedish health care regions a total of 42,220 female breast cancer patients below 90 years of age were diagnosed between 1989 and 2013. They were treated and followed according to national and regional guidelines and formed a population-based cohort...
December 4, 2018: Acta Oncologica
Maria Stenman, Michael Staehler, Bernadett Szabados, Per Sandström, Anna Laurell, Magnus Lindskog, Ulrika Harmenberg
BACKGROUND: Metastatic papillary renal cell carcinoma (mPRCC) is understudied. The disease is often aggressive and specific treatment options are lacking. PATIENTS AND METHODS: mPRCC patients (n = 86) referred to three academic centres in Sweden and Germany in the years 2005-2015 were retrospectively identified from medical records. Statistical analyses included Kaplan-Meier curves and calculation of Cox proportional hazards, generating hazard ratios with 95% confidence intervals...
December 3, 2018: Acta Oncologica
Boris Peltenburg, Bart de Keizer, Jan Willem Dankbaar, Mirthe de Boer, Stefan M Willems, Marielle E P Philippens, Chris H J Terhaard, Remco de Bree
INTRODUCTION: Accurate assessment of cervical lymph node status is essential in patients with head and neck squamous cell carcinoma (HNSCC) as it influences prognosis and treatment decisions. During patient workup, lymph node status is often examined by ultrasound guided fine needle aspiration cytology (USgFNAC). 18 F-Fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG PET-CT) is frequently used to assess primary tumor and distant metastases but provides information on lymph node status as well...
November 29, 2018: Acta Oncologica
Bengt Glimelius
No abstract text is available yet for this article.
November 29, 2018: Acta Oncologica
Peter Moberger, Filip Sköldberg, Helgi Birgisson
BACKGROUND: The Swedish Colorectal Cancer Registry (SCRCR) is a national registry established in 1995 for rectal cancer, and also including colon cancer since 2007. Knowledge of the quality of the registry is vital in order to draw correct conclusions from studies based on the registry. The aim of this study was to assess the completeness, timeliness, comparability and validity of the SCRCR. MATERIAL AND METHODS: Completeness, timeliness and comparability of the registry were estimated...
November 26, 2018: Acta Oncologica
Daniëlle B P Eekers, Erik Roelofs, Macarena Cubillos-Mesías, Charles Niël, Robert Jan Smeenk, Ann Hoeben, Andre W H Minken, Marlies Granzier, Geert O Janssens, Johannes H A M Kaanders, Philippe Lambin, Esther G C Troost
BACKGROUND AND PURPOSE: Patients with low-grade glioma (LGG) have a prolonged survival expectancy due to better discriminative tumor classification and multimodal treatment. Consequently, long-term treatment toxicity gains importance. Contemporary radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), tomotherapy (TOMO) and intensity-modulated proton therapy (IMPT) enable high-dose irradiation of the target but they differ regarding delivered dose to organs at risk (OARs)...
November 26, 2018: Acta Oncologica
Cathrine F Hjorth, Anja S Nielsen, Henrik T Sørensen, Timothy L Lash, Per Damkier, Stephen Hamilton-Dutoit, Deirdre Cronin-Fenton
BACKGROUND: Adjuvant tamoxifen therapy approximately halves the risk of recurrence in estrogen receptor-positive (ER+) breast cancer patients, but many women respond insufficiently to therapy. Expression of multi-drug resistance protein 2 (MRP2) in breast cancer may potentiate tamoxifen resistance. Thus, we investigated the expression of MRP2 in breast cancer as a predictor of tamoxifen therapy effectiveness. MATERIAL AND METHODS: We conducted a case-control study nested in the Danish Breast Cancer Group clinical database...
November 20, 2018: Acta Oncologica
Neil O'Morain, Deirdre McNamara
Advances in colorectal polyp detection and resection methods aim to reduce interval cancer rates. Complete polypectomy is essential to reduce the risk of early recurrence and the development of interval cancers. To achieve this, polyps must first be correctly identified and then completely excised. This article reviews current adenoma detection methods in use and the management of residual disease.
November 20, 2018: Acta Oncologica
Brendan J Moran
No abstract text is available yet for this article.
November 19, 2018: Acta Oncologica
Sarah Baker, Aman Sharma, Robert Peric, Wilma D Heemsbergen, Joost Jan Nuyttens
BACKGROUND/PURPOSE: To investigate prognostic factors for death within 6 months of stereotactic body radiotherapy (SBRT) for patients with peripheral early-stage non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: This analysis included 586 NSCLC patients with peripheral tumors treated with SBRT. Potential patient and tumor prognostic factors, including the Charlson Comorbidity Index (CCI) and Cumulative Illness Rating Scale (CIRS), were analyzed by logistic regression analysis for association with early mortality (death <6 months after SBRT)...
November 19, 2018: Acta Oncologica
Jean-Paul J E Kleijnen, Bram van Asselen, Robbe Van den Begin, Martijn Intven, Johannes P M Burbach, Onne Reerink, Marielle E P Philippens, Mark de Ridder, Jan J W Lagendijk, Bas W Raaymakers
BACKGROUND: In patients diagnosed with rectal cancer, dose escalation is currently being investigated in a large number of studies. Since there is little known on gross tumor volume (GTV) inter-fraction motion for rectal cancer, a wide variety in margins is used. Purpose of this study is to quantify GTV inter-fraction motion statistics on different timescales and to give estimates of planning target volume (PTV) margins. MATERIAL AND METHODS: Thirty-two patients, diagnosed with rectal cancer, were included...
November 16, 2018: Acta Oncologica
Axel Stenmark Tullberg, Dan Lundstedt, Roger Olofsson Bagge, Per Karlsson
BACKGROUND: In luminal A-like breast cancer, the indication for adjuvant chemotherapy still is largely based on lymph nodestatus. Sentinel node (SN) positive patients who are no longer recommended an axillary lymph node dissection (ALND) risk undertreatment, especially if they have ≥4 lymph node metastases (LNMs). AIM: To quantify the group of SN positive luminal A-like patients with ≥4 LNMs and to investigate if the ratio between positive SNs and examined SNs (SN ratio) can provide information of the axillary tumor burden...
November 8, 2018: Acta Oncologica
Jinhan Zhu, Jun Zhang, Bo Qiu, Yimei Liu, Xiaowei Liu, Lixin Chen
BACKGROUND: In this study, a deep convolutional neural network (CNN)-based automatic segmentation technique was applied to multiple organs at risk (OARs) depicted in computed tomography (CT) images of lung cancer patients, and the results were compared with those generated through atlas-based automatic segmentation. MATERIALS AND METHODS: An encoder-decoder U-Net neural network was produced. The trained deep CNN performed the automatic segmentation of CT images for 36 cases of lung cancer...
November 6, 2018: Acta Oncologica
Bengt Glimelius, Per Pfeiffer
No abstract text is available yet for this article.
November 1, 2018: Acta Oncologica
Cecilia M Lund, Kirsten K Vistisen, Christian Dehlendorff, Finn Rønholt, Julia S Johansen, Dorte L Nielsen
OBJECTIVES: First-line chemotherapy for metastatic colorectal cancer (mCRC) is effective and feasible in selected older patients. We investigated age-dependent differences in treatment and outcomes in patients with mCRC in clinical practice. MATERIAL AND METHODS: A retrospective study of 654 patients with mCRC referred to first-line chemotherapy in 2008-2014. Patients were divided into two age groups: 50-69 and ≥70 (older patients). Binary outcomes were analyzed by logistic regression...
October 30, 2018: Acta Oncologica
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