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Acta Oncologica

Olivier Mir, Maud Toulmonde, Romain Coriat, Stanislas Ropert, Pierre Loulergue
No abstract text is available yet for this article.
October 24, 2016: Acta Oncologica
Matthew D Hall, Timothy E Schultheiss, David D Smith, Marwan G Fakih, Jeffrey Y C Wong, Yi-Jen Chen
BACKGROUND: Neoadjuvant chemoradiation therapy (CRT) increases pathological complete response (pCR) rates compared to radiotherapy alone in patients with stage II-III rectal cancer. Limited evidence addresses whether radiotherapy dose escalation further improves pCR rates. Our purpose is to measure the effects of radiotherapy dose and other factors on post-therapy pathologic tumor (ypT) and nodal stage in rectal cancer patients treated with neoadjuvant CRT followed by mesorectal excision...
October 20, 2016: Acta Oncologica
Anna Ehinger, Per Malmström, Pär-Ola Bendahl, Christopher W Elston, Anna-Karin Falck, Carina Forsare, Dorthe Grabau, Lisa Rydén, Olle Stål, Mårten Fernö
BACKGROUND: The St Gallen surrogate definition of the intrinsic subtypes of breast cancer consist of five subgroups based on estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor type 2 (HER2), and Ki-67. PgR and Ki-67 are used for discriminating between the 'Luminal A-like' and 'Luminal B-like (HER2-negative)' subtypes. Histological grade (G) has prognostic value in breast cancer; however, its relationship to the St Gallen subtypes is not clear. Based on a previous pilot study, we hypothesized that G could be a primary discriminator for ER-positive/HER2-negative breast cancers that were G1 or G3, whereas Ki-67 and PgR could provide additional prognostic information specifically for patients with G2 tumors...
October 20, 2016: Acta Oncologica
Katarina Tomic, Marcus Westerberg, David Robinson, Hans Garmo, Pär Stattin
BACKGROUND: Knowledge on missing data in a clinical cancer register is important to assess the validity of research results. For analysis of prostate cancer (Pca), risk category, a composite variable based on serum levels of prostate specific antigen (PSA), stage, and Gleason score, is crucial for treatment decisions and a strong determinant of outcome. The aim of this study was to assess the proportion and characteristics of men in the National Prostate Cancer Register (NPCR) of Sweden with unknown risk category...
October 17, 2016: Acta Oncologica
Angela Botticella, Gilles Defraene, Kristiaan Nackaerts, Christophe M Deroose, Johan Coolen, Philippe Nafteux, Stephanie Peeters, Umberto Ricardi, Dirk De Ruysscher
BACKGROUND: The gross tumor volume (GTV) definition for malignant pleural mesothelioma (MPM) is ill-defined. We therefore investigated which imaging modality is optimal: computed tomography (CT) with intravenous contrast (IVC), positron emission tomography-CT (PET/CT) or magnetic resonance imaging (MRI). MATERIAL AND METHODS: Sixteen consecutive patients with untreated stage I-IV MPM were included. Patients with prior pleurodesis were excluded. CT with IVC, 18FDG-PET/CT and MRI (T2 and contrast-enhanced T1) were obtained...
October 12, 2016: Acta Oncologica
Vitali Moiseenko, John Einck, James Murphy, Jakob Ödén, Judith Bjöhle, Julien Uzan, Giovanna Gagliardi
No abstract text is available yet for this article.
October 12, 2016: Acta Oncologica
Maziar Nikberg, Abbas Chabok, Henry Letocha, Csaba Kindler, Bengt Glimelius, Kenneth Smedh
BACKGROUND: Adjuvant chemotherapy for stage II and III rectal cancer patients is a matter of discussion. The aim of the present study was to evaluate the prognostic value of lymphovascular (LVI) and perineural (PNI) invasion in stage II rectal cancer on a national level. MATERIALS AND METHODS: Clinico-pathological factors associated with disease-free survival (DFS) and time to recurrence in stage II rectal cancer patients were analyzed from patient data registered in the Swedish Colorectal Cancer Registry between 2006 and 2012...
October 12, 2016: Acta Oncologica
Jaan Soplepmann, Piret Laidre
No abstract text is available yet for this article.
October 10, 2016: Acta Oncologica
Norbert M Verweij, Anandi H W Schiphorst, Apollo Pronk, Frederiek van den Bos, Marije E Hamaker
BACKGROUND: Decision making regarding cancer treatment is challenging and there is a need for clinical parameters that can guide these decisions. As physical performance appears to be a reflection of health status, the aim of this systematic review is to assess whether physical performance tests (PPTs) are predictive of the clinical outcome and treatment tolerance in cancer patients. METHODS: A literature search was conducted on 2 April 2015 in the electronic databases Medline and Embase to identify studies focusing on the association between objectively measured PPTs and outcome...
October 8, 2016: Acta Oncologica
Erling A Bringeland, Hans H Wasmuth, Patricia Mjønes, Tor Å Myklebust, Jon E Grønbech
BACKGROUND: Population-based studies for gastric adenocarcinoma are scarce, particularly studies conducted within a defined geographical area with publicly available censuses that allow incidence rates to be calculated. MATERIAL AND METHODS: Population-based study in Central Norway from 2001 to 2011, covering a population of 636 000-680 000, respectively. Patients were identified through the Cancer Registry of Norway and the Norwegian Patient Register, and were characterized by data from individual electronic patient records...
October 6, 2016: Acta Oncologica
Christina Caroline Plaschke, Anita Gothelf, Julie Gehl, Irene Wessel
BACKGROUND: Electrochemotherapy, the combination of electroporation and chemotherapy, is mainly used in the palliative setting for treatment of cutaneous and subcutaneous metastases; however, new applications are continuously being explored. Patients with head and neck cancer are primarily treated with surgery and/or radio-chemotherapy. In the setting of local recurrence with no further curative treatment options available, electrochemotherapy could be of value. We therefore performed a systematic search of the present literature...
October 5, 2016: Acta Oncologica
Evamaria Müller, Pola Hahlweg, Isabelle Scholl
BACKGROUND: Shared decision making (SDM) is particularly relevant in oncology, where complex treatment options with varying side effects may lead to meaningful changes in the patient's quality of life. For several years, health policies have called for the implementation of SDM, but SDM remains poorly implemented in routine clinical practice. Implementation science has highlighted the importance of assessing stakeholders' needs to inform the development of implementation programs. Thus, the aim of the present study was to assess different stakeholders' needs regarding the implementation of SDM in routine care...
September 8, 2016: Acta Oncologica
Davy G H A van Dam, Antoinetta J M Beijers, Gerard Vreugdenhil
No abstract text is available yet for this article.
September 8, 2016: Acta Oncologica
Piet Dirix, Lien van Walle, Filip Deckers, François Van Mieghem, Guido Buelens, Paul Meijnders, Philippe Huget, Steven Van Laere
BACKGROUND: A subset of patients experience a biochemical recurrence following radical prostatectomy. Radiotherapy can salvage those patients, provided that all disease is encompassed within the target volume. We hypothesized that this can be achieved more adequately with magnetic resonance imaging (MRI)-guided treatment planning. MATERIAL AND METHODS: From January 2009 to April 2014, 183 patients were referred to our department for salvage radiotherapy (SRT). According to protocol, patients received a planning computed tomography (CT) as well as an MRI in treatment position...
September 1, 2016: Acta Oncologica
Lieke G E M Razenberg, Geert-Jan Creemers, Laurens V Beerepoot, Allert H Vos, Agnes J van de Wouw, Huub A A M Maas, Valery E P P Lemmens
BACKGROUND: Although the spectrum of systemic treatment for metastatic colorectal cancer (mCRC) has widened, there is a paucity of evidence for the feasibility and optimal use of these systemic agents in elderly patients. The present study provides real world data on the age-related systemic treatment and survival of CRC patients with non-resectable metachronous metastases. METHODS: All consecutive patients with non-resectable metastases from primary resected CRC were extracted from the Eindhoven area of the Netherlands Cancer Registry (NCR)...
September 1, 2016: Acta Oncologica
Mitchell S Anscher, Michael G Chang, Drew Moghanaki, Mihaela Rosu, Ross B Mikkelsen, Diane Holdford, Vicki Skinner, B Mayer Grob, Arun Sanyal, Aiping Wang, Nitai D Mukhopadhyay
No abstract text is available yet for this article.
September 1, 2016: Acta Oncologica
Nobuaki Hoshino, Suguru Hasegawa, Koya Hida, Kenji Kawada, Riki Ganeko, Kenichi Sugihara, Yoshiharu Sakai
BACKGROUND: There have been no established criteria to distinguish patients at high and low risk of recurrence in stage II colorectal cancer. Several risk factors have been identified but recurrence could not be fully predicted by each factor alone. This retrospective study sought to develop a nomogram for accurate prediction of recurrence in stage II colorectal cancer. MATERIAL AND METHODS: We reviewed the data for 4167 patients with stage II colorectal cancer who underwent surgery between January 1997 and December 2006...
September 1, 2016: Acta Oncologica
Line H Schack, Jan Alsner, Jens Overgaard, Christian Nicolaj Andreassen, Birgitte V Offersen
No abstract text is available yet for this article.
September 1, 2016: Acta Oncologica
Ronit Gurion, Pia Raanani, Liat Vidal, Avi Leader, Anat Gafter-Gvili
BACKGROUND: The choice of a specific tyrosine kinase inhibitor (TKI) as first line treatment in chronic myeloid leukemia (CML) is complex and influenced by multiple factors. We published a meta-analysis examining the role of newer TKIs as first line treatment in chronic phase CML. In view of the recently published data, we decided to update it. METHODS: We conducted a systematic review and meta-analysis of randomized controlled trials comparing first line treatment with imatinib to the newer TKIs (nilotinib, dasatinib, bosutinib and ponatinib)...
August 25, 2016: Acta Oncologica
Magnus Björkholm
No abstract text is available yet for this article.
August 24, 2016: Acta Oncologica
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