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Acta Oncologica

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https://www.readbyqxmd.com/read/27924664/assessment-of-ethnic-differences-in-sunitinib-outcome-between-caucasian-and-asian-patients-with-metastatic-renal-cell-carcinoma-a-meta-analysis
#1
Xiaoyan Liu, Marta Fiocco, Jesse J Swen, Henk-Jan Guchelaar
BACKGROUND: An increasing number of studies have reported ethnic differences in sunitinib outcome in metastatic renal cell carcinoma (mRCC) patients. However, a comprehensive analysis is still lacking. Therefore, we systematically collected available published data and performed a meta-analysis to compare sunitinib efficacy and toxicity in Asian and Caucasian mRCC patients. METHODS: Data were extracted from published results from clinical trials, expanded access program and real-world clinical practice...
December 7, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27924653/healthcare-resource-use-comorbidity-treatment-and-clinical-outcomes-for-patients-with-primary-intracranial-tumors-a-swedish-population-based-register-study
#2
Jenny Bergqvist, Hanna Iderberg, Johan Mesterton, Nils Bengtsson, Björn Wettermark, Roger Henriksson
BACKGROUND: Primary intracranial tumors are relatively uncommon and heterogeneous, which make them challenging to study. We coupled data from unique Swedish population-based registries in order to deeper analyze the most common intracranical tumor types. Patient characteristics (e.g. comorbidities), care process measures like adherence to national guidelines, healthcare resource use and clinical outcome was evaluated. MATERIALS AND METHODS: A register-based study including several population-based registries for all patients living in Stockholm-Gotland, diagnosed with primary intracranial tumor between 2001 and 2013 was performed...
December 7, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27924652/risk-of-second-cancers-in-survivors-of-prolymphocytic-leukemia-a-seer-data-analysis
#3
Mohamed Abd El-Fattah
No abstract text is available yet for this article.
December 7, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27921521/high-frequency-of-osteonecrosis-of-the-jaw-among-denosumab-treated-prostate-cancer-patients
#4
Leena Vehmanen, Juho Suojanen, Risto Kontio, Tapio Utriainen, Carl Blomqvist
No abstract text is available yet for this article.
December 6, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27919198/occupational-sedentariness-and-breast-cancer-risk
#5
Anna Johnsson, Per Broberg, Anders Johnsson, Åsa B Tornberg, Håkan Olsson
BACKGROUND: Epidemiological studies have indicated that physical activity reduces the risk of developing breast cancer. More recently, sedentary behavior has been suggested as a risk factor independent of physical activity level. The purpose of the present study was to investigate occupational sedentariness and breast cancer risk in pre- and postmenopausal women. MATERIALS AND METHODS: In a population-based prospective cohort study (n = 29 524), working history was assessed by a questionnaire between 1990 and 1992...
December 6, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27911139/volumetric-response-of-intracranial-meningioma-after-photon-or-particle-irradiation
#6
Petra Mozes, Jan Oliver Dittmar, Daniel Habermehl, Eric Tonndorf-Martini, Katalin Hideghety, Anne Dittmar, Jürgen Debus, Stephanie E Combs
BACKGROUND: Meningiomas are usually slow growing, well circumscribed intracranial tumors. In symptom-free cases observation with close follow-up imaging could be performed. Symptomatic meningiomas could be surgically removed and/or treated with radiotherapy. The study aimed to evaluate the volumetric response of intracranial meningiomas at different time points after photon, proton, and a mixed photon and carbon ion boost irradiation. PATIENTS AND METHODS: In Group A 38 patients received proton therapy (median dose: 56 GyE in 1...
December 2, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27911129/socioeconomic-position-and-mortality-among-patients-with-prostate-cancer-influence-of-mediating-factors
#7
Signe Benzon Larsen, Klaus Brasso, Jane Christensen, Christoffer Johansen, Anne Tjønneland, Søren Friis, Peter Iversen, Susanne Oksbjerg Dalton
INTRODUCTION: Men with low socioeconomic position experience higher mortality after a prostate cancer diagnosis compared to men with a higher socioeconomic position, however, the specific mediators of this association are unclear. We therefore evaluated the influence of potential mediators on the association between socioeconomic position, and prostate cancer-specific and all-cause death in prostate cancer patients. MATERIALS AND METHODS: We conducted a cohort study of prostate cancer patients in the Danish Diet, Cancer and Health study...
December 2, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27911128/s-1-in-combination-with-docetaxel-and-oxaliplatin-in-patients-with-advanced-gastro-esophageal-adenocarcinoma-two-parallel-phase-1-2a-studies
#8
Per Pfeiffer, Camilla Qvortrup, Merete Krogh, Katrine Schoennemann, Lene W Vestermark, Helle A Jensen, Jon K Bjerregaard
BACKGROUND: Docetaxel in combination with cisplatin and 5-fluorouracil (5-FU) is one of several standard chemotherapy regimens for patients with advanced gastro-esophageal adenocarcinoma (aGEA) in Europe. To enable outpatient treatment, we evaluated the maximum tolerated dose (MTD), recommended dose (RD), dose limiting toxicity (DLT) and safety of docetaxel in combination with oxaliplatin (O) and S-1 (DOS) in Caucasian patients with aGEA. METHODS: We present final results of two parallel phase 1/2a studies (3 + 3 design)...
December 2, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27911126/anti-pd1-treatment-in-metastatic-uveal-melanoma-in-the-netherlands
#9
M K van der Kooij, A Joosse, F M Speetjens, G A P Hospers, C Bisschop, J W B de Groot, R Koornstra, C U Blank, E Kapiteijn
No abstract text is available yet for this article.
December 2, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27892773/real-world-data-on-nivolumab-treatment-of-non-small-cell-lung-cancer
#10
O T Brustugun, M Sprauten, Å Helland
BACKGROUND: Checkpoint inhibitors have proven effectiveness in clinical trials for non-small cell lung cancer (NSCLC) patients, but if this is congruent with routine patient care is discussed. We present real-world experience with the PD1-inhibitor nivolumab in NSCLC. PATIENTS AND METHODS: Patients with NSCLC were considered eligible for nivolumab treatment after one or more lines of chemotherapy, and when in reasonable performance status (PS) [Eastern Cooperative Oncology Group (ECOG) < 3]...
November 28, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27885879/a-high-preoperative-carbohydrate-antigen-19-9-level-is-a-risk-factor-for-recurrence-in-stage-ii-colorectal-cancer
#11
Hiroaki Nozawa, Soichiro Ishihara, Kazushige Kawai, Keisuke Hata, Tomomichi Kiyomatsu, Toshiaki Tanaka, Takeshi Nishikawa, Kensuke Otani, Koji Yasuda, Kazuhito Sasaki, Koji Murono, Toshiaki Watanabe
BACKGROUND: Many risk factors for recurrence in stage II colorectal cancer (CRC) have been proposed, and the efficacy of adjuvant chemotherapy is still controversial. This study aimed to identify risk factors for tumor recurrence and assess whether they are related to the benefits of adjuvant chemotherapy in stage II CRC. MATERIAL AND METHODS: Patients with stage II CRC that was curatively operated on in a tertiary hospital between 2005 and 2014 were analyzed. Cox's proportional hazards models were applied to identify risk factors for recurrence and overall mortality...
November 25, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27885876/predictors-and-survival-for-pathologic-tumor-response-grade-in-borderline-resectable-and-locally-advanced-pancreatic-cancer-treated-with-induction-chemotherapy-and-neoadjuvant-stereotactic-body-radiotherapy
#12
Eric A Mellon, William H Jin, Jessica M Frakes, Barbara A Centeno, Tobin J Strom, Gregory M Springett, Mokenge P Malafa, Ravi Shridhar, Pamela J Hodul, Sarah E Hoffe
BACKGROUND: Neoadjuvant therapy response correlates with survival in multiple gastrointestinal malignancies. To potentially augment neoadjuvant response for pancreas adenocarcinoma, we intensified treatment with stereotactic body radiotherapy (SBRT) following multi-agent chemotherapy. Using this regimen, we analyzed whether the College of American Pathology (CAP) tumor regression grade (TRG) at pancreatectomy correlated with established response biomarkers and survival. MATERIALS AND METHODS: We identified borderline resectable (BRPC) and locally advanced (LAPC) pancreatic cancer patients treated according to our institutional clinical pathway who underwent surgical resection with reported TRG (n = 81, median follow-up after surgery 24...
November 25, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27885868/a-case-report-of-iatrogenic-cutaneous-kaposi-sarcoma-due-to-rituximab-therapy-for-thrombotic-thrombocytopenic-purpura
#13
Kimberly Jerdan, Joshua Brownell, Manu Singh, Marylee Braniecki, Lawrence Chan
No abstract text is available yet for this article.
November 25, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27885864/probabilistic-treatment-planning-for-pancreatic-cancer-treatment-prospective-incorporation-of-respiratory-motion-shows-only-limited-dosimetric-benefit
#14
Eelco Lens, Alexis N T J Kotte, Ajay Patel, Hanne D Heerkens, Matthieu Bal, Geertjan van Tienhoven, Arjan Bel, Astrid van der Horst, Gert J Meijer
BACKGROUND: We introduced a probabilistic treatment planning approach that prospectively incorporates respiratory-induced motion in the treatment plan optimization. The aim of this study was to determine the potential dosimetric benefit by comparing this approach to the use of an internal target volume (ITV). MATERIAL AND METHOD: We retrospectively compared the probabilistic respiratory motion-incorporated (RMI) approach to the ITV approach for 18 pancreatic cancer patients, for seven simulated respiratory amplitudes from 5 to 50 mm in the superior-inferior (SI) direction...
November 25, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27882820/phase-ii-randomized-study-of-the-igf-1r-pathway-modulator-axl1717-compared-to-docetaxel-in-patients-with-previously-treated-locally-advanced-or-metastatic-non-small-cell-lung-cancer
#15
Michael Bergqvist, Georg Holgersson, Igor Bondarenko, Elena Grechanaya, Alexey Maximovich, György Andor, Maria Klockare, Marcus Thureson, Markus Jerling, Johan Harmenberg
BACKGROUND: The primary objective of this study was to compare the progression-free survival (PFS) at 12 weeks between patients treated with IGF-1R pathway modulator AXL1717 (AXL) and patients treated with docetaxel (DCT). MATERIAL AND METHODS: The study was conducted at 19 study centers in five countries. A total of 99 patients with previously treated, locally advanced or metastatic non-small cell lung cancer (NSCLC) of the squamous cell carcinoma (SCC) or adenocarcinoma (AC) subtypes in need of additional treatment were randomized and treated with either 300 or 400 mg of AXL as daily BID treatment (58 patients) or DCT given as 75 mg/m(2) in three-week cycles (41 patients) as monotherapy in a 3:2 ratio for each NSCLC subtype...
November 24, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27882806/comorbidity-as-a-predictor-of-overall-survival-in-prostate-cancer-patients-treated-with-external-beam-radiotherapy-combined-with-hdr-brachytherapy-boosts
#16
Marie Hjälm-Eriksson, Anders Ullén, Hemming Johansson, Seymoure Levitt, Sten Nilsson, Karl-Mikael Kälkner
BACKGROUND: The risk stratification currently applied prior to curative treatment for localized prostate cancer (PC) does not take into account comorbidity or age. Therefore, we investigated the impact of comorbidity on overall survival (OS) in PC patients treated with external beam radiotherapy (EBRT) and high-dose rate (HDR) brachytherapy boost. MATERIAL AND METHODS: At a single center, 611 consecutive patients diagnosed with localized PC from 1998 to 2004 underwent definitive EBRT (50 Gy) and HDR brachytherapy boosts (2 × 10 Gy) combined with neoadjuvant total androgen blockade...
November 24, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27846764/impact-of-age-intrinsic-subtype-and-local-treatment-on-long-term-local-regional-recurrence-and-breast-cancer-mortality-among-low-risk-breast-cancer-patients
#17
Tinne Laurberg, Jan Alsner, Trine Tramm, Vibeke Jensen, Christina D Lyngholm, Peer M Christiansen, Jens Overgaard
AIM: To evaluate the long-term prognostic impact of age, local treatment and intrinsic subtypes on the risk of local-regional recurrence (LRR) and breast cancer mortality among low-risk patients. MATERIAL AND METHODS: Cohort study with prospectively collected data, balanced five-year age groups, including 514 Danish lymph node negative breast cancer patients diagnosed between 1989 and 1998, treated with mastectomy (N = 320) or breast-conserving therapy (BCT) (N = 194) and without systemic treatment...
November 16, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27846763/outcomes-after-primary-or-adjuvant-radiotherapy-for-salivary-gland-carcinoma
#18
Adam Holtzman, Christopher G Morris, Robert J Amdur, Peter T Dziegielewski, Brian Boyce, William M Mendenhall
BACKGROUND: We report long-term outcomes of patients treated with primary radiotherapy (RT) or surgery and adjuvant RT for salivary gland malignancies. MATERIALS AND METHODS: From 1964 to 2012, 291 patients received primary RT (n = 67) or RT combined with surgery (n = 224). RESULTS: The 5-, 10-, and 15-year local control, local-regional control, distant metastasis-free survival, cause-specific survival and overall survival rates were 82%, 77% and 73%; 77%, 72% and 67%; 74%, 70% and 70%; 70%, 59% and 54%; and 63%, 47% and 38%, respectively...
November 16, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27846762/gender-specific-survival-after-surgical-resection-for-early-stage-non-small-cell-lung-cancer
#19
Anders Bugge, Johny Kongerud, Cathrine Brunborg, Steinar Solberg, May Brit Lund
BACKGROUND: Lung cancer is the leading cause of cancer death worldwide. The incidence and mortality rate of lung cancer in women has increased. Studies have indicated that females with non-small cell lung cancer (NSCLC) have better survival than males. We aimed to examine the impact of gender on 1-, 5- and 10-year survival after surgery for stage I and II NSCLC. MATERIALS AND METHODS: During the period 2003-2013, 692 patients operated for stage I and II NSCLC were prospectively registered...
November 16, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27846757/accuracy-requirements-and-uncertainties-in-radiotherapy-a-report-of-the-international-atomic-energy-agency
#20
Debbie van der Merwe, Jacob Van Dyk, Brendan Healy, Eduardo Zubizarreta, Joanna Izewska, Ben Mijnheer, Ahmed Meghzifene
BACKGROUND: Radiotherapy technology continues to advance and the expectation of improved outcomes requires greater accuracy in various radiotherapy steps. Different factors affect the overall accuracy of dose delivery. Institutional comprehensive quality assurance (QA) programs should ensure that uncertainties are maintained at acceptable levels. The International Atomic Energy Agency has recently developed a report summarizing the accuracy achievable and the suggested action levels, for each step in the radiotherapy process...
November 16, 2016: Acta Oncologica
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