journal
MENU ▼
Read by QxMD icon Read
search

Acta Oncologica

journal
https://www.readbyqxmd.com/read/28524711/the-will-to-live-breast-cancer-patients-perceptions-of-palliative-chemotherapy
#1
Jenny Bergqvist, Peter Strang
BACKGROUND: For women with metastatic breast cancer, late lines of chemotherapy might be beneficial but also harmful. Ongoing chemotherapy late in life increase the risk of late or absent discussions of palliative care and access to symptom relief by other options than chemotherapy. Our aim was, therefore, to investigate breast cancer patients' motives, perceptions, and experiences of late lines of palliative oncologic treatment. MATERIAL AND METHODS: A qualitative study with semi-guided face-to-face interviews with 20 women on at least their second line of palliative chemotherapy (second-eighth line)...
May 19, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28524708/significance-of-baseline-fdg-pet-ct-scan-as-a-method-of-staging-regional-lymph-nodes-in-patients-with-operable-distal-oesophageal-or-gastroesophageal-junction-adenocarcinoma
#2
George Papaxoinis, Jamie M J Weaver, Leila Khoja, Ana Patrao, Sofia Stamatopoulou, Alia Alchawaf, Vikki Owen-Holt, Theodora Germetaki, Zoe Kordatou, Wasat Mansoor
BACKGROUND: The new American Joint Committee on Cancer eighth edition (AJCC8) staging is the first to describe separate clinical and pathology staging systems, but still has low performance to predict prognosis in patients with oesophageal/gastroesophageal junction (O/GOJ) adenocarcinoma, who are candidates for surgery. Recent studies have demonstrated that O/GOJ cancer patients with 18F-fluorodeoxyglucose (FDG) avid regional lymph nodes (RLNs) may have poor prognosis. The aim of our study was to examine whether the baseline assessment of the FDG uptake of RLN improves the prognostic accuracy of the new AJCC8 staging...
May 19, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28521651/miliary-metastases-are-associated-with-epidermal-growth-factor-receptor-mutations-in-non-small-cell-lung-cancer-a-population-based-study
#3
Fred Hsu, Alan Nichol, Ted Toriumi, Alex De Caluwe
BACKGROUND: Miliary metastases are characterized by metastatic nodules that are diffuse, innumerable and small. The purpose of this study was to examine the incidence, prognostic significance and impact of epidermal growth factor receptor (EGFR) mutations for miliary metastases from non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: Patients were identified from a Provincial cancer registry (British Columbia, Canada) for the period 2010-2012. Inclusion criteria were stage IV NSCLC at presentation and conclusive EGFR mutation testing...
May 19, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28509651/the-concept-of-immunocompromised-district-might-explain-the-carcinogenic-progression-in-hidradenitis-suppurativa
#4
Valerio De Vita, Eleonora Ruocco
No abstract text is available yet for this article.
May 16, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28509599/a-review-of-dosimetric-and-toxicity-modeling-of-proton-versus-photon-craniospinal-irradiation-for-pediatrics-medulloblastoma
#5
Evangeline S Q Ho, Sarah A Barrett, Laura M Mullaney
BACKGROUND: Craniospinal irradiation (CSI) is the standard radiation therapy treatment for medulloblastoma. Conventional CSI photon therapy (Photon-CSI) delivers significant dose to surrounding normal tissue (NT). Research into pediatric CSI with proton therapy (Proton-CSI) has increased, with the aim of exploiting the potential to reduce NT dose and associated post-treatment complications. This review aims to compare treatment outcomes of pediatric medulloblastoma patients between Proton- and Photon-CSI treatments...
May 16, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28503990/assessing-the-utilization-of-radiotherapy-near-end-of-life-at-a-finnish-university-hospital-a-retrospective-cohort-study
#6
Liisa K Rautakorpi, Johanna M Mäkelä, Fatemeh Seyednasrollah, Anna M Hammais, Tarja Laitinen, Outi M Hirvonen, Heikki Minn, Laura L Elo, Sirkku M Jyrkkiö
BACKGROUND: Palliative radiotherapy can improve quality of life for cancer patients during the last months of life. However, very short life expectancy may devastate the benefit of the treatment. This single center study assesses the utilization of radiotherapy during the last weeks of life. MATERIAL AND METHODS: All cancer patients (N = 38,982) treated with radiotherapy (N = 11,395) in Turku University Central Hospital during 2005-2013 were identified in the database consisting of electronic patient records...
May 13, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28502238/parotid-gland-mean-dose-as-a-xerostomia-predictor-in-low-dose-domains
#7
Hubert Szymon Gabryś, Florian Buettner, Florian Sterzing, Henrik Hauswald, Mark Bangert
PURPOSE: Xerostomia is a common side effect of radiotherapy resulting from excessive irradiation of salivary glands. Typically, xerostomia is modeled by the mean dose-response characteristic of parotid glands and prevented by mean dose constraints to either contralateral or both parotid glands. The aim of this study was to investigate whether normal tissue complication probability (NTCP) models based on the mean radiation dose to parotid glands are suitable for the prediction of xerostomia in a highly conformal low-dose regime of modern intensity-modulated radiotherapy (IMRT) techniques...
May 13, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28497999/bullet-fragment-fiducials-in-stereotactic-body-radiotherapy-as-a-bridge-to-transplant-for-hepatocellular-carcinoma
#8
Jamie S K Takayesu, Kathryn R Tringale, Deborah C Marshall, Jeffrey Burkeen, Mark A Valasek, Alan Hemming, Todd Atwood, Daniel Simpson, Jona Hattangadi-Gluth
No abstract text is available yet for this article.
May 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28488914/decitabine-treatment-of-multiple-extramedullary-acute-myeloid-leukemia-involvements-after-essential-thrombocytemia-transformation
#9
Pasquale Niscola, Elisabetta Abruzzese, Malgorzata Monika Trawinska, Massimiliano Palombi, Andrea Tendas, Marco Giovannini, Laura Scaramucci, Luca Cupelli, Stefano Fratoni, Nélida Inés Noguera, Gianfranco Catalano, Paolo de Fabritiis
No abstract text is available yet for this article.
May 10, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28488912/a-high-level-of-estrogen-stimulated-proteins-selects-breast-cancer-patients-treated-with-adjuvant-endocrine-therapy-with-good-prognosis
#10
Katrine L H Weischenfeldt, Tove Kirkegaard, Birgitte B Rasmussen, Anita Giobbie-Hurder, Maj-Britt Jensen, Bent Ejlertsen, Anne E Lykkesfeldt
BACKGROUND: Adjuvant endocrine therapy has significantly improved survival of estrogen receptor α (ER)-positive breast cancer patients, but around 20% relapse within 10 years. High expression of ER-stimulated proteins like progesterone receptor (PR), Bcl-2 and insulin-like growth factor receptor I (IGF-IR) is a marker for estrogen-driven cell growth. Therefore, patients with high tumor levels of these proteins may have particularly good prognosis following adjuvant endocrine therapy...
May 10, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28486004/the-role-of-comorbidity-in-the-management-and-prognosis-in-nonsmall-cell-lung-cancer-a-population-based-study
#11
Jonas Nilsson, Anders Berglund, Stefan Bergström, Michael Bergqvist, Mats Lambe
BACKGROUND: Coexisting disease constitutes a challenge for the provision of optimal cancer care. The influence of comorbidity on lung cancer management and prognosis remains incompletely understood. We assessed the influence of comorbidity on treatment intensity and prognosis in a population-based setting in patients with nonsmall cell lung cancer. MATERIAL AND METHODS: Our study was based on information available in Lung Cancer Data Base Sweden (LcBaSe), a database generated by record linkage between the National Lung Cancer Register (NLCR) and several other population-based registers in Sweden...
May 9, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28481677/metastatic-melanoma-in-a-95-years-old-patient-responding-to-treatment-with-talimogene-laherparepvec-followed-by-nivolumab
#12
Abdul R Naqash, Geoffrey Stroud, Frances A Collichio, Mahvish Muzaffar, Nitika Sharma, Paul Walker
No abstract text is available yet for this article.
May 8, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28447539/feasibility-of-preference-driven-radiotherapy-dose-treatment-planning-to-support-shared-decision-making-in-anal-cancer
#13
Heidi S Rønde, Leonard Wee, John Pløen, Ane L Appelt
PURPOSE/OBJECTIVE: Chemo-radiotherapy is an established primary curative treatment for anal cancer, but clinically equal rationale for different target doses exists. If joint preferences (physician and patient) are used to determine acceptable tradeoffs in radiotherapy treatment planning, multiple dose plans must be simultaneously explored. We quantified the degree to which different toxicity priorities might be incorporated into treatment plan selection, to elucidate the feasible decision space for shared decision making in anal cancer radiotherapy...
April 27, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28438067/gene-therapy-for-patients-with-advanced-solid-tumors-a-phase-i-study-using-gene-electrotransfer-to-muscle-with-the-integrin-inhibitor-plasmid-amep
#14
Iben Spanggaard, Karin Dahlstroem, Line Laessoee, Rasmus Hvass Hansen, Helle Hjorth Johannesen, Helle Westergren Hendel, Céline Bouquet, Pierre Attali, Julie Gehl
BACKGROUND: Gene electrotrotransfer describes the use of electric pulses to transfer DNA to cells. Particularly skeletal muscle has potential for systemic secretion of therapeutic proteins. Gene electrotransfer to muscle using the integrin inhibitor plasmid AMEP (Antiangiogenic MEtargidin Peptide) was investigated in a phase I dose escalation study. Primary objective was safety. MATERIAL AND METHODS: Patients with metastatic or locally advanced solid tumors, without further standard treatments available, were treated with once-only gene electrotransfer of plasmid AMEP to the femoral muscle...
April 25, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28431480/predictive-and-prognostic-factors-associated-with-soft-tissue-sarcoma-response-to-chemotherapy-a-subgroup-analysis-of-the-european-organisation-for-research-and-treatment-of-cancer-62012-study
#15
Robin J Young, Saskia Litière, Michela Lia, Pancras C W Hogendoorn, Cyril Fisher, Gunhild Mechtersheimer, Søren Daugaard, Raf Sciot, Françoise Collin, Christina Messiou, Viktor Grünwald, Alessandro Gronchi, Winette van der Graaf, Eva Wardelmann, Ian Judson
BACKGROUND: The European Organization for Research and Treatment of Cancer (EORTC) 62012 study was a Phase III trial of doxorubicin versus doxorubicin-ifosfamide chemotherapy in 455 patients with advanced soft tissue sarcoma (STS). Analysis of the main study showed that combination chemotherapy improved tumor response and progression-free survival, but differences in overall survival (OS) were not statistically significant. We analyzed factors prognostic for tumor response and OS, and assessed histological subgroup and tumor grade as predictive factors to identify patients more likely to benefit from combination chemotherapy...
April 21, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28423966/linear-energy-transfer-distributions-in-the-brainstem-depending-on-tumour-location-in-intensity-modulated-proton-therapy-of-paediatric-cancer
#16
Lars Fredrik Fjæra, Zuofeng Li, Kristian S Ytre-Hauge, Ludvig P Muren, Daniel J Indelicato, Yasmin Lassen-Ramshad, Grete May Engeseth, Marianne Brydøy, Andrea Mairani, Stella Flampouri, Olav Dahl, Camilla H Stokkevåg
BACKGROUND: For tumours near organs at risk, there is concern about unintended increase in biological dose from elevated linear energy transfer (LET) at the distal end of treatment fields. The objective of this study was therefore to investigate how different paediatric posterior fossa tumour locations impact LET and biological dose to the brainstem during intensity-modulated proton therapy (IMPT). MATERIAL AND METHODS: Multiple IMPT plans were generated for four different simulated tumour locations relative to the brainstem for a five-year-old male patient...
April 19, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28422584/pre-and-post-prostatectomy-variables-associated-with-pelvic-post-operative-radiotherapy-in-prostate-cancer-patients-a-national-registry-based-study
#17
Kari Vatne, Andreas Stensvold, Tor Å Myklebust, Bjørn Møller, Aud Svindland, Rune Kvåle, Sophie D Fosså
BACKGROUND: In patients with prostate cancer (PCa), the lack of clear guidelines on the use of radiotherapy after radical prostatectomy (RP) invites unwanted variation of this treatment. We describe the hazard ratios and probabilities related to the use of post-RP radiotherapy. MATERIAL AND METHODS: Data were collected from the Cancer Registry of Norway and nine radiotherapy units. All patients were diagnosed with a non-metastatic PCa from January 2004 through June 2011...
April 19, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28418710/lung-cancer-guidelines-in-sweden-denmark-norway-and-finland-a-comparison
#18
Niels Lyhne Christensen, Antti Jekunen, Sebastian Heinonen, Susanne Oksbjerg Dalton, Torben Riis Rasmussen
BACKGROUND: The Nordic countries are similar in terms of demographics and health care organization. Yet there are marked differences in lung cancer mortality, for which Denmark historically has had the poorest outcome. One of several possible reasons for these differences could have to do with how lung cancer is diagnosed and treated in the different Nordic countries. However, among the four most populous Nordic countries: Sweden, Denmark, Norway and Finland, there is a paucity of knowledge about differences and similarities in recommendations in the national guidelines for non-small cell lung cancer (NSCLC) and the methodology by which the guidelines are developed...
April 18, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28401808/associations-between-volume-changes-and-spatial-dose-metrics-for-the-urinary-bladder-during-local-versus-pelvic-irradiation-for-prostate-cancer
#19
Oscar Casares-Magaz, Vitali Moiseenko, Austin Hopper, Niclas Johan Pettersson, Maria Thor, Rick Knopp, Joseph O Deasy, Ludvig Paul Muren, John Einck
BACKGROUND: Inter-fractional variation in urinary bladder volumes during the course of radiotherapy (RT) for prostate cancer causes deviations between planned and delivered doses. This study compared planned versus daily cone-beam CT (CBCT)-based spatial bladder dose distributions, for prostate cancer patients receiving local prostate treatment (local treatment) versus prostate including pelvic lymph node irradiation (pelvic treatment). MATERIAL AND METHODS: Twenty-seven patients (N = 15 local treatment; N = 12 pelvic treatment) were treated using daily image-guided RT (1...
April 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28388257/accuracy-of-the-dose-shift-approximation-in-estimating-the-delivered-dose-in-sbrt-of-lung-tumors-considering-setup-errors-and-breathing-motions
#20
Kristin Karlsson, Ingmar Lax, Elias Lindbäck, Gavin Poludniowski
INTRODUCTION: Geometrical uncertainties can result in a delivered dose to the tumor different from that estimated in the static treatment plan. The purpose of this project was to investigate the accuracy of the dose calculated to the clinical target volume (CTV) with the dose-shift approximation, in stereotactic body radiation therapy (SBRT) of lung tumors considering setup errors and breathing motion. The dose-shift method was compared with a beam-shift method with dose recalculation...
April 7, 2017: Acta Oncologica
journal
journal
29603
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"