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Acta Oncologica

Kishor Hadkhale, Jan Ivar Martinsen, Elisabete Weiderpass, Kristina Kjærheim, Pär Sparén, Laufey Tryggvadóttir, Elsebeth Lynge, Eero Pukkala
BACKGROUND: Occupational exposure has been identified as the most important risk factor for bladder cancer second to smoking. The objective of this study was to estimate the occupational variation in risk of bladder cancer that is not attributable to smoking. MATERIAL AND METHODS: In the Nordic Occupational Cancer study (NOCCA), 111,458 cases of bladder cancer and 208,297 cases of lung cancer cases were observed among men in Denmark, Finland, Iceland, Norway and Sweden during 1961-2005...
October 15, 2018: Acta Oncologica
Klas Holmgren, Markku M Haapamäki, Peter Matthiessen, Jörgen Rutegård, Martin Rutegård
BACKGROUND: A permanent stoma after anterior resection for rectal cancer is common. Nationwide registries provide sufficient power to evaluate factors influencing this phenomenon, but validation is required to ensure the quality of registry-based stoma outcomes. METHODS: Patients who underwent anterior resection for rectal cancer in the Northern healthcare region of Sweden between 1 January 2007 and 31 December 2013 were reviewed by medical records and followed until 31 December 2014 with regard to stoma outcome...
October 11, 2018: Acta Oncologica
Yangkun Luo, Yujin Xu, Zhongxing Liao, Daniel Gomez, Jingqian Wang, Wei Jiang, Rongrong Zhou, Ryan Williamson, Laurence E Court, Jinzhong Yang
PURPOSE: We evaluated the feasibility of using an automatic segmentation tool to delineate cardiac substructures from noncontrast computed tomography (CT) images for cardiac dosimetry and toxicity analyses for patients with nonsmall cell lung cancer (NSCLC) after radiotherapy. MATERIAL AND METHODS: We used an in-house developed multi-atlas segmentation tool to delineate 11cardiac substructures, including the whole heart, four heart chambers, and six greater vessels, automatically from the averaged 4D-CT planning images of 49 patients with NSCLC...
October 11, 2018: Acta Oncologica
Peng Jin, Koen F Crama, Jorrit Visser, Niek van Wieringen, Arjan Bel, Maarten C C M Hulshof, Tanja Alderliesten
PURPOSE: To investigate the dosimetric effect of variable gas volume in esophageal cancer radiation therapy (RT) and whether a density override (DO) in treatment planning can effectively mitigate this dosimetric effect. MATERIAL AND METHODS: Nine patients with gastrointestinal gas pockets in the planning computed tomography (pCT) were retrospectively included. Per patient, the intensity-modulated RT (IMRT) and volumetric-modulated arc therapy (VMAT) plans associated with no DO, DO = 0...
October 5, 2018: Acta Oncologica
Sahar Salehi, Yvonne Brandberg, Elisabeth Åvall-Lundqvist, Chikako Suzuki, Hemming Johansson, Berit Legerstam, Henrik Falconer
PURPOSE: The health-related quality of life (HRQoL) outcomes after comprehensive surgical staging including infrarenal paraaortic lymphadenectomy in women with high-risk endometrial cancer (EC) are unknown. Our aim was to investigate the long-term HRQoL between robot-assisted laparoscopic surgery (RALS) and laparotomy (LT). PATIENTS AND METHODS: A total of 120 women with high-risk stage I-II EC were randomised to RALS or LT for hysterectomy, bilateral salpingoophorectomy, pelvic and infrarenal paraaortic lymphadenectomy in the previously reported Robot-Assisted Surgery for High-Risk Endometrial Cancer trial...
October 5, 2018: Acta Oncologica
J Castelli, A Simon, C Lafond, N Perichon, B Rigaud, E Chajon, B De Bari, M Ozsahin, J Bourhis, R de Crevoisier
INTRODUCTION: Large anatomical variations can be observed during the treatment course intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC), leading to potential dose variations. Adaptive radiotherapy (ART) uses one or several replanning sessions to correct these variations and thus optimize the delivered dose distribution to the daily anatomy of the patient. This review, which is focused on ART in the HNC, aims to identify the various strategies of ART and to estimate the dosimetric and clinical benefits of these strategies...
October 5, 2018: Acta Oncologica
Aman Sharma, Marloes Duijm, Esther Oomen-de Hoop, Joachim G Aerts, Cornelis Verhoef, Mischa Hoogeman, Joost Jan Nuyttens
BACKGROUND: Stereotactic body radiotherapy (SBRT) for pulmonary oligometastatic disease achieves excellent treatment outcomes in terms of local control and toxicity. Patients treated with SBRT are often elderly and have multiple co-morbidities. This subset of patients may experience different survival as compared to young and fit patients subjected to radical metastasectomies. The purpose of this retrospective study was to evaluate OS and identify factors associated with OS for inoperable pulmonary oligometastases treated with SBRT...
October 3, 2018: Acta Oncologica
Dennis Winkel, Petra S Kroon, Anita M Werensteijn-Honingh, Gijsbert H Bol, Bas W Raaymakers, Ina M Jürgenliemk-Schulz
PURPOSE: Online 1.5T MR imaging on the MR-linac gives better target visualization compared to CBCT and facilitates online adaptive treatment strategies including daily replanning. In this simulation study, the dosimetric impact of online replanning was investigated for SBRT of lymph node oligometastases as a method for correcting for inter-fraction anatomical changes. METHODS: Pre-treatment plans were created for 17 pelvic and para-aortic lymph nodes, with 3 and 8 mm PTV margins reflecting our clinical practice for lymph nodes with good and poor visibility on CBCT...
October 3, 2018: Acta Oncologica
S M C H Langenberg, A K L Reyners, A N M Wymenga, G C M Sieling, C M M Veldhoven, C M L van Herpen, J B Prins, W T A van der Graaf
BACKGROUND: TKIs are a long-term treatment for GIST, and may have an impact on caregivers. MATERIAL AND METHODS: For this cross-sectional study, patients and caregivers were both included when patients had been treated with TKIs for at least six months. Caregivers completed questionnaires including demographics, distress (Hospital Anxiety and Depression scale), burden (Self-Perceived Pressure from Informal Care) general health (RAND-36), comorbidity (Self-administered Comorbidity Questionnaire), social support (Social Support List - Discrepancies) and marital satisfaction (Maudsley Marital Questionnaire)...
October 3, 2018: Acta Oncologica
Anneli Edvardsson, Malin Kügele, Sara Alkner, Marika Enmark, Joakim Nilsson, Ingrid Kristensen, Elisabeth Kjellén, Silke Engelholm, Sofie Ceberg
BACKGROUND: Late effects induced by radiotherapy (RT) are of great concern for mediastinal Hodgkin's lymphoma (HL) patients and it is therefore important to reduce normal tissue dose. The aim of this study was to investigate the impact on the normal tissue dose and target coverage, using various combinations of intensity modulated proton therapy (IMPT), volumetric modulated arc therapy (VMAT) and 3-dimensional conformal RT (3D-CRT), planned in both deep inspiration breath hold (DIBH) and free breathing (FB)...
October 3, 2018: Acta Oncologica
Marianne Ørum, Merete Gregersen, Kenneth Jensen, Peter Meldgaard, Else Marie S Damsgaard
OBJECTIVES: The purposes were to investigate the health status of elderly cancer patients by comprehensive geriatric assessment (CGA) and to compare the complications with respect to baseline CGA and to evaluate the need for geriatric interventions in an elderly cancer patients' population. MATERIAL: Patients aged ≥70 years with lung cancer (LC), cancer of the head and neck (HNC), colorectal cancer (CRC), or upper gastro-intestinal cancer (UGIC) are referred to the Department of Oncology for cancer treatment...
October 3, 2018: Acta Oncologica
Kaire Innos, Teesi Sepp, Aleksei Baburin, Andres Kotsar, Katrin Lang, Peeter Padrik, Tiiu Aareleid
BACKGROUND: Kidney cancer rates in Estonia are high. The study aimed to examine long-term trends in kidney cancer incidence, mortality and survival in Estonia, with special focus on age, birth cohorts, morphology and TNM stage. MATERIAL AND METHODS: Estonian Cancer Registry provided data on all incident cases of kidney cancer (ICD-10 C64), diagnosed in adults (age ≥15 years) in Estonia during 1995 - 2014. Relative survival ratios (RSR) were calculated and excess hazard ratios of dying were estimated with gender, age, period of diagnosis and TNM stage as independent variables...
October 3, 2018: Acta Oncologica
Torleiv Skjøtskift, Morten E Evensen, Torbjørn Furre, Jon M Moan, Cecilie D Amdal, Trond V Bogsrud, Eirik Malinen, Einar Dale
BACKGROUND: For patients with recurrent or second primary disease, re-irradiation can be challenging due to overlap with previously irradiated volumes. Dose painting may be attractive for these patients, as the focus is on delivering maximal dose to areas of high tumor activity. Here, we compare dose painting by contours (DPBC) treatment plans based on 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) with conventional plans. MATERIAL AND METHODS: We included 10 patients with recurrent or second primary head and neck cancer (HNC) eligible for re-irradiation...
October 3, 2018: Acta Oncologica
Hiroaki Ogawa, Kei Ito, Takuya Shimizuguchi, Tomohisa Furuya, Keiji Nihei, Katsuyuki Karasawa
PURPOSE: Stereotactic body radiotherapy (SBRT) is expected to achieve safe and effective re-irradiation for painful bone metastases. This study aimed to clarify the efficacy of re-irradiation using SBRT for painful bone metastases. METHODS: Prospective database at our institution for the period between September 2013 and December 2017 were retrospectively reviewed for patients with: (1) painful bone metastases; (2) history of radiotherapy to the metastasis; and (3) SBRT performed as re-irradiation...
October 3, 2018: Acta Oncologica
Jeffrey M Ryckman, Vaishnavi Ganesan, Adams Kusi Appiah, Chi Zhang, Vivek Verma
OBJECTIVES: To examine patterns of care associated with the administration of proton versus photon therapy for adult patients with primary brain tumors in a large national cohort from the United States. METHODS: The National Cancer Database (NCDB) was queried for newly diagnosed primary brain tumors (2004-2014) in adult patients aged 18 and older receiving proton or photon radiotherapy. Clinical features, patient demographics and treatment parameters were extracted...
October 3, 2018: Acta Oncologica
Olof Sjöström, Gustav Silander, Ingvar Syk, Roger Henriksson, Beatrice Melin, Barbro N Hellquist
BACKGROUND: Geographic cancer health disparities have been reported in Sweden. The disparities are not fully understood, but may be attributed to differences in exposure to risk factors as well as differences in health care, socioeconomics and demography. The aim of this study was to describe the new nationwide population based RISK North database and its potential by analysing health disparities in colorectal cancer between Northern and Southern Sweden. METHODS: Cancer-specific data from the National Cancer Quality Registers for colorectal, gastric and oesophageal cancer and brain tumours were linked to several nationwide registers hereby creating a new database - RISK North...
October 3, 2018: Acta Oncologica
Barbara Alicja Jereczek-Fossa, Matteo Muto, Stefano Durante, Annamaria Ferrari, Gaia Piperno, Cristiana Fodor, Stefania Comi, Rosalinda Ricotti, Cristina Garibaldi, Samantha Dicuonzo, Stefano Mazza, Federica Golino, Lorenzo Spaggiari, Filippo De Marinis, Roberto Orecchia, Delia Ciardo, Piero Fossati
PURPOSE: To evaluate the treatment-induced toxicity (as primary endpoint) and the efficacy (as secondary endpoint) of stereotactic body radiation therapy (SBRT) in the treatment of mediastinal lymph nodes (LNs) in the so-called no-fly zone (NFZ) in cancers with various histology. MATERIAL AND METHODS: Forty-two patients were retrospectively analyzed. Institutional dose/volume constraints for organs at risk (OARs) derived by published data were strictly respected...
October 3, 2018: Acta Oncologica
Anne Gulbech Ording, Buket Öztürk, Karen-Lise Garm Spindler, Henrik Toft Sørensen, Margaret McCusker, Vera Ehrenstein
No abstract text is available yet for this article.
September 28, 2018: Acta Oncologica
Marije Weidema, Suzanne Kaal, Loek de Jong, Nielka van Erp, Rosemarie Jansen, Bart Schreuder, Wieteke Heidema, Winette van der Graaf, Ingrid Desar
No abstract text is available yet for this article.
September 28, 2018: Acta Oncologica
Felice N van Erning, Tara M Mackay, Lydia G M van der Geest, B Groot Koerkamp, Hanneke W M van Laarhoven, Bert A Bonsing, Johanna W Wilmink, Hjalmar C van Santvoort, Judith de Vos-Geelen, Casper H J van Eijck, Olivier R Busch, Valery E Lemmens, Marc G Besselink
BACKGROUND: The association between pancreatic ductal adenocarcinoma (PDAC) location (head, body, tail) and tumor stage, treatment and overall survival (OS) is unclear. METHODS: Patients with PDAC diagnosed between 2005 and 2015 were included from the population-based Netherlands Cancer Registry. Patient, tumor and treatment characteristics were compared with the tumor locations. Multivariable logistic and Cox regression analyses were used. RESULTS: Overall, 19,023 patients were included...
September 28, 2018: Acta Oncologica
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