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Acta Oncologica

Gianni Gerlini, Lara Tripo, Serena Sestini, Paola Brandani, Vanni Giannotti, Riccardo Gattai, Lorenzo Borgognoni
No abstract text is available yet for this article.
June 20, 2018: Acta Oncologica
Floortje Mols, Olga Husson, Marije Oudejans, Carla Vlooswijk, Nicole Horevoorts, Lonneke V van de Poll-Franse
OBJECTIVE: Cancer and its treatment have an influence on health-related quality of life (HRQOL). Normative data could help to interpret HRQOL among cancer patients. Our aim was to generate longitudinal normative data based on sex, age and morbidity for the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire. METHODS: The QLQ-C30 and the Self-administered Comorbidity Questionnaire were administered to a representative panel of the Dutch-speaking population in the Netherlands in 2009 (n = 1743), 2010 (n = 2050), 2011 (n = 2040), 2012 (n = 2194) and 2013 (n = 2333)...
June 18, 2018: Acta Oncologica
Tor Magnus Smedman, Pål-Dag Line, Tormod K Guren, Svein Dueland
No abstract text is available yet for this article.
June 18, 2018: Acta Oncologica
Montelius Anders
No abstract text is available yet for this article.
June 18, 2018: Acta Oncologica
Annikki Aromaa-Häyhä, Päivi Auvinen, Tytti Sarkeala, Sirpa Heinävaara, Annamarja Lamminmäki, Nea Malila, Vesa Kataja
BACKGROUND: Generally, screen-detected cancers have more favourable tumour characteristics than clinically detected or symptomatic cancers. Less is known, whether the tumour characteristics of breast cancer have changed over time into more favourable in general and whether the changes have been similar in all ages. MATERIAL AND METHODS: The aim of this study was to explore the change of breast cancer characteristics in parallel to the implementation of modern diagnostic methods in three age groups over four 5-year time periods between 1992 and 2011...
June 8, 2018: Acta Oncologica
Linda Rainey, Daniëlle van der Waal, Yvonne Wengström, Anna Jervaeus, Mireille J M Broeders
INTRODUCTION: Increased knowledge of breast cancer risk factors may enable a paradigm shift from the current age-based mammographic screening programmes to a personalised risk-based approach. This would warrant a significant change in practice, yet the acceptability from a woman's perspective has never been systematically explored. In this systematic review, we inventoried and appraised studies of women's perceptions of risk-based breast cancer screening and prevention to identify factors associated with adopting this new paradigm...
June 8, 2018: Acta Oncologica
Ícaro T Carvalho, Willy Baccaglini, Oliver R Claros, Felipe K Chen, Paulo P Kayano, Gustavo C Lemos, Eduardo Weltman, Deborah A Kuban, Arie Carneiro
BACKGROUND: Hypofractionated (HRT) prostate radiation therapy has the potential to deliver a higher biologically effective dose over a shorter time compared with conventional fractionation (CRT). HRT, giving fewer fractions each with higher dose, might improve the therapeutic ratio, resource use and patient convenience but the toxicity is still controversial. Our objective was to compare the gastroinstestinal (GI) and genitourinary (GU) toxicity of HRT versus CRT. METHODS: Systematic review and meta-analysis of randomized clinical trials studies in PubMed, Cochrane and EMBASE databases published through December 2016 was done...
June 8, 2018: Acta Oncologica
Chris Monten, Liv Veldeman, Katrien Vandecasteele, Luiza Oltéanu, Werner De Gersem, Tom Vercauteren, Thomas Mulliez, Rudy Van Den Broecke, Herman Depypere, Wilfried De Neve, Yolande Lievens
INTRODUCTION: In view of the limited incremental benefit between whole breast irradiation (WBI), accelerated partial breast irradiation (APBI) and omission of radiotherapy in favorable early-stage breast cancer (ESBC), APBI can only be justified if it combines adequate target coverage with the lowest achievable toxicity. Interobserver exercises demonstrated the difficulty of precise target delineation, especially in prone position; information on accuracy is even scarcer. We tested the impact of inserting an additional indicator clip, marking the depth of the tumor in the breast, and the added value of a preoperative CT in treatment position on precision and accuracy...
June 6, 2018: Acta Oncologica
Donata von Reibnitz, Fauzia Shaikh, Abraham J Wu, Gregory C Treharne, Rosalind Dick-Godfrey, Amanda Foster, Kaitlin M Woo, Weiji Shi, Zhigang Zhang, Shaun U Din, Daphna Y Gelblum, Ellen D Yorke, Kenneth E Rosenzweig, Andreas Rimner
BACKGROUND: Stereotactic body radiotherapy (SBRT) has been adopted as the standard of care for inoperable early-stage non-small cell lung cancer (NSCLC), with local control rates consistently >90%. However, data directly comparing the outcomes of SBRT with those of conventionally fractionated radiotherapy (CONV) is lacking. MATERIAL AND METHODS: Between 1990 and 2013, 497 patients (525 lesions) with early-stage NSCLC (T1-T2N0M0) were treated with CONV (n = 127) or SBRT (n = 398)...
June 6, 2018: Acta Oncologica
Marie K Langberg, Carina Berglund-Nord, Gabriella Cohn-Cedermark, Hege S Haugnes, Torgrim Tandstad, Carl W Langberg
BACKGROUND: An increasing number of anticancer drugs have been reported to cause pneumonitis. Chemotherapy-induced pneumonitis may cause severe morbidity and event death. As there has been a lack of effective treatment, new treatment strategies are needed. A previous case report has indicated that imatinib may be useful. PATIENT AND METHODS: The SWENOTECA experience of four cases with severe life-threatening chemotherapy-induced pneumonitis treated with imatinib is presented...
June 5, 2018: Acta Oncologica
P Penttilä, P Bono, K Peltola, F Donskov
BACKGROUND: The prognostication of metastatic renal cell carcinoma (mRCC) is based on Memorial Sloan Kettering Cancer Center (MSKCC) and International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk classifications. Research has shown that hyponatremia is associated with worse prognosis in cancer. We analyzed the association of hyponatremia and outcome in everolimus-treated mRCC patients. PATIENTS AND METHODS: Baseline and on-treatment (≤12 weeks) sodium in 233 mRCC patients was analyzed using Kaplan-Meier, Cox regression and logistic regression...
June 4, 2018: Acta Oncologica
Anniina Tolkkinen, Laura Madanat-Harjuoja, Mervi Taskinen, Matti Rantanen, Nea Malila, Janne Pitkäniemi
INTRODUCTION: Parental socioeconomic status has been proposed to have an influence on childhood cancer mortality even in high-income countries. Our study investigated the influence of parental socioeconomic factors on childhood cancer mortality. MATERIAL AND METHODS: We identified 4437 patients diagnosed with cancer under the age of 20 from 1990 to 2009 and their parents from the Finnish cancer and central population registers. Information on death from primary cancer during five-year follow-up and parental socioeconomic factors was obtained from Statistics Finland...
June 4, 2018: Acta Oncologica
Giampaolo Pileggi, Christoph Speier, Gregory C Sharp, David Izquierdo Garcia, Ciprian Catana, Jennifer Pursley, Francesco Amato, Joao Seco, Maria Francesca Spadea
BACKGROUND: In radiotherapy, MR imaging is only used because it has significantly better soft tissue contrast than CT, but it lacks electron density information needed for dose calculation. This work assesses the feasibility of using pseudo-CT (pCT) generated from T1w/T2w MR for proton treatment planning, where proton range comparisons are performed between standard CT and pCT. MATERIAL AND METHODS: MR and CT data from 14 glioblastoma patients were used in this study...
May 29, 2018: Acta Oncologica
Helena Sandström, Hidefumi Jokura, Caroline Chung, Iuliana Toma-Dasu
BACKGROUND: Although accurate delineation of the target is a key factor of success in radiosurgery there are no consensus guidelines for target contouring. AIM: The aim of the present study was therefore to quantify the variability in target delineation and discuss the potential clinical implications, for six targets regarded as common in stereotactic radiosurgery. MATERIAL AND METHODS: Twelve Gamma Knife centers participated in the study by contouring the targets and organs at risks and performing the treatment plans...
May 22, 2018: Acta Oncologica
Sophie E Heethuis, Lucas Goense, Peter S N van Rossum, Alicia S Borggreve, Stella Mook, Francine E M Voncken, Annemarieke Bartels-Rutten, Berthe M P Aleman, Richard van Hillegersberg, Jelle P Ruurda, Gert J Meijer, Jan J W Lagendijk, Astrid L H M W van Lier
PURPOSE: To explore the potential benefit and complementary value of a multiparametric approach using diffusion-weighted (DW-) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI) for prediction of response to neoadjuvant chemoradiotherapy (nCRT) in esophageal cancer. MATERIAL AND METHODS: Forty-five patients underwent both DW-MRI and DCE-MRI prior to nCRT (pre), during nCRT (week 2-3) (per) and after completion of nCRT, but prior to esophagectomy (post)...
May 21, 2018: Acta Oncologica
Line V Hjelle, Per O M Gundersen, Ragnhild Hellesnes, Mette Sprauten, Marianne Brydøy, Torgrim Tandstad, Tom Wilsgaard, Sophie D Fosså, Jan Oldenburg, Roy M Bremnes, Hege S Haugnes
BACKGROUND: The long-term toxicities after cisplatin-based chemotherapy (CBCT) reveal a remarkable inter-individual variation among testicular cancer survivors (TCSs). Therefore, we assessed long-term platinum (Pt) changes and their associations with CBCT-related late effects in TCSs. MATERIAL AND METHODS: In 77 TCSs treated with CBCT from 1984 to 1990, blood samples for analyses of Pt and a questionnaire including self-reported neuro- and ototoxicity (NTX) symptoms were collected during two follow-up surveys at median 12 (Survey I; SI) and 20 (Survey II; SII) years after treatment...
May 18, 2018: Acta Oncologica
Gonzalo Tapia Rico, Christos Karapetis, Amanda R Townsend, Cynthia Piantadosi, Rob Padbury, Amitesh Roy, Guy Maddern, James Moore, Scott Carruthers, David Roder, Timothy J Price
No abstract text is available yet for this article.
May 18, 2018: Acta Oncologica
Jakob Schmidt Jensen, Christian Grønhøj, Christian Mirian, Thomas Hjuler
No abstract text is available yet for this article.
May 18, 2018: Acta Oncologica
Donna H Murrell, Andrew Warner, Quinn Benwell, Wendy Wells, Danielle Scott, Vikram Velker, George Hajdok, David P D'Souza
BACKGROUND: Intensity modulated radiotherapy (IMRT) is increasingly being used to treat gynaecological malignancies in the postoperative setting. The purpose of this study was to evaluate the use of image-guided radiotherapy (IGRT) using cone-beam computed tomography (CBCT) with fiducial markers for daily localization. MATERIAL AND METHODS: A single institution study was performed of consecutive cervical or endometrial cancer patients receiving adjuvant external beam radiotherapy (n = 15)...
May 18, 2018: Acta Oncologica
Marla Karine Amarante, Glauco Akelinghton Freire Vitiello, Marcos Henrique Rosa, Igor Alves Mancilla, Maria Angelica Ehara Watanabe
Medulloblastoma (MB) is the most common malignant brain tumor occurring in children, and although high long-term survival rates have been reached with current therapeutic protocols, several neurological injuries are still observed among survivors. It has been shown that the development of MB is highly dependent on the microenvironment surrounding it and that the CXCL12 chemokine and its receptor, CXCR4 and the Sonic Hedgehog (SHH) pathway are crucial for cerebellar development, coordinating proliferation and migration of embryonic cells and malfunctions in these axes can lead to MB development...
May 17, 2018: Acta Oncologica
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