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Acta Oncologica

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https://www.readbyqxmd.com/read/28828925/towards-ion-beam-therapy-based-on-laser-plasma-accelerators
#1
Leonhard Karsch, Elke Beyreuther, Wolfgang Enghardt, Malte Gotz, Umar Masood, Ulrich Schramm, Karl Zeil, Jörg Pawelke
Only few ten radiotherapy facilities worldwide provide ion beams, in spite of their physical advantage of better achievable tumor conformity of the dose compared to conventional photon beams. Since, mainly the large size and high costs hinder their wider spread, great efforts are ongoing to develop more compact ion therapy facilities. One promising approach for smaller facilities is the acceleration of ions on micrometre scale by high intensity lasers. Laser accelerators deliver pulsed beams with a low pulse repetition rate, but a high number of ions per pulse, broad energy spectra and high divergences...
August 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28828923/impact-of-model-and-dose-uncertainty-on-model-based-selection-of-oropharyngeal-cancer-patients-for-proton-therapy
#2
Rik G Bijman, Sebastiaan Breedveld, Tine Arts, Eleftheria Astreinidou, Martin A de Jong, Patrick V Granton, Steven F Petit, Mischa S Hoogeman
BACKGROUND: Proton therapy is becoming increasingly available, so it is important to apply objective and individualized patient selection to identify those who are expected to benefit most from proton therapy compared to conventional intensity modulated radiation therapy (IMRT). Comparative treatment planning using normal tissue complication probability (NTCP) evaluation has recently been proposed. This work investigates the impact of NTCP model and dose uncertainties on model-based patient selection...
August 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28828920/data-quality-in-the-swedish-quality-register-of-gynecologic-cancer-a-swedish-gynecologic-cancer-group-swegcg-study
#3
Per Rosenberg, Preben Kjølhede, Christian Staf, Maria Bjurberg, Christer Borgfeldt, Pernilla Dahm-Kähler, Kristina Hellman, Elisabet Hjerpe, Erik Holmberg, Karin Stålberg, Bengt Tholander, Elisabeth Åvall Lundqvist, Thomas Högberg
AIM: The aim of this study is to evaluate the quality of data on endometrial (EC) and ovarian, fallopian tube, peritoneal, abdominal or pelvic cancers (OC) registered in the Swedish Quality Register of Gynecologic Cancer (SQRGC). METHOD: A random sample of 500 patients was identified in the SQRGC and their medical charts were reviewed for re-abstraction of 31 selected core variables by an independent validator. The data in the SQRGC and the re-abstracted data were compared...
August 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28828913/impact-of-respiratory-motion-on-variable-relative-biological-effectiveness-in-4d-dose-distributions-of-proton-therapy
#4
Silke Ulrich, Hans-Peter Wieser, Wenhua Cao, Radhe Mohan, Mark Bangert
BACKGROUND: Organ motion during radiation therapy with scanned protons leads to deviations between the planned and the delivered physical dose. Using a constant relative biological effectiveness (RBE) of 1.1 linearly maps these deviations into RBE-weighted dose. However, a constant value cannot account for potential nonlinear variations in RBE suggested by variable RBE models. Here, we study the impact of motion on recalculations of RBE-weighted dose distributions using a phenomenological variable RBE model...
August 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28828905/the-activity-and-safety-of-novel-proteasome-inhibitors-strategies-single-doublet-and-triplet-for-relapsed-refractory-multiple-myeloma
#5
Huanwen Ma, Zheng Su, Fengqiang Sun, Ningning Zhao
PURPOSE: We sought to evaluate the activity and safety of these novel proteasome inhibitors (PIs) (carfilzomib, ixazomib, oprozomib and marizomib) containing regimens (single, doublet and triplet) for relapsed/refractory multiple myeloma (R/RMM). METHODS: We searched published reports including these novel PIs containing regimens for R/RMM. RESULTS: Finally, we identified 28 prospective studies that evaluated 4123 patients. Pooled analysis showed that novel PIs doublet combinations attained an impressive overall response rate (ORR) of 67%, which was higher than that of 22% from novel PIs single-agent (p < ...
August 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28826311/development-of-an-interlaced-crossfiring-geometry-for-proton-grid-therapy
#6
Thomas Henry, Niels Bassler, Ana Ureba, Toshiro Tsubouchi, Alexander Valdman, Albert Siegbahn
BACKGROUND: Grid therapy has in the past normally been performed with single field photon-beam grids. In this work, we evaluated a method to deliver grid therapy based on interlacing and crossfiring grids of mm-wide proton beamlets over a target volume, by Monte Carlo simulations. MATERIAL AND METHODS: Dose profiles for single mm-wide proton beamlets (1, 2 and 3 mm FWHM) in water were simulated with the Monte Carlo code TOPAS. Thereafter, grids of proton beamlets were directed toward a cubic target volume, located at the center of a water tank...
August 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28826308/the-influence-of-breathing-motion-and-a-variable-relative-biological-effectiveness-in-proton-therapy-of-left-sided-breast-cancer
#7
Jakob Ödén, Iuliana Toma-Dasu, Kjell Eriksson, Anna Maria Flejmer, Alexandru Dasu
BACKGROUND: Proton breast radiotherapy has been suggested to improve target coverage as well as reduce cardiopulmonary and integral dose compared with photon therapy. This study aims to assess this potential when accounting for breathing motion and a variable relative biological effectiveness (RBE). METHODS: Photon and robustly optimized proton plans were generated to deliver 50 Gy (RBE) in 25 fractions (RBE = 1.1) to the CTV (whole left breast) for 12 patients...
August 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28826307/feature-selection-methodology-for-longitudinal-cone-beam-ct-radiomics
#8
Janna E van Timmeren, Ralph T H Leijenaar, Wouter van Elmpt, Bart Reymen, Philippe Lambin
BACKGROUND: Cone-beam CT (CBCT) scans are typically acquired daily for positioning verification of non-small cell lung cancer (NSCLC) patients. Quantitative information, derived using radiomics, can potentially contribute to (early) treatment adaptation. The aims of this study were to (1) describe and investigate a methodology for feature selection of a longitudinal radiomics approach (2) investigate which time-point during treatment is potentially useful for early treatment response assessment...
August 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28826304/moderate-dose-escalation-with-volumetric-modulated-arc-therapy-improves-outcome-in-rectal-cancer
#9
Cedric Stuyck, Marilyn Wegge, Philippe Bulens, Ines Joye, Karin Haustermans
BACKGROUND: Locally advanced rectal cancer is frequently treated with a long course of preoperative chemoradiotherapy. We investigated the effect of moderate dose escalation with volumetric modulated arc therapy (VMAT) up to 50 Gy in 25 fractions compared to 3D conformal radiotherapy (3D-CRT) to 45 Gy in 25 fractions in rectal cancer patients. Dose-volume parameters, acute toxicity, and complete response rates were compared. MATERIAL AND METHODS: For both groups, 65 patients were selected from our database through availability...
August 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28826293/analysis-of-ct-verified-loco-regional-recurrences-after-definitive-imrt-for-hnscc-using-site-of-origin-estimation-methods
#10
Ruta Zukauskaite, Christian R Hansen, Carsten Brink, Jørgen Johansen, Jon T Asmussen, Cai Grau, Jens Overgaard, Jesper G Eriksen
INTRODUCTION: A significant part of patients with head and neck squamous cell carcinoma (HNSCC) develop recurrent disease after curative radiotherapy. We aimed to analyze loco-regional recurrence pattern by identifying possible points of recurrence origin by three different methods in relation to treatment volumes. MATERIAL AND METHODS: A total of 455 patients completed IMRT-based treatment for HNSCC from 2006 to 2012. A total of 159 patients had remaining cancer after IMRT, developed loco-regional recurrence or distant disease during follow-up...
August 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28826292/radiobiological-issues-in-proton-therapy
#11
Radhe Mohan, Christopher R Peeler, Fada Guan, Lawrence Bronk, Wenhua Cao, David R Grosshans
The relative biological effectiveness (RBE) for particle therapy is a complex function of particle type, radiation dose, linear energy transfer (LET), cell type, endpoint, etc. In the clinical practice of proton therapy, the RBE is assumed to have a fixed value of 1.1. This assumption, along with the effects of physical uncertainties, may mean that the biologically effective dose distributions received by the patient may be significantly different from what is seen on treatment plans. This may contribute to unforeseen toxicities and/or failure to control the disease...
August 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28820311/clinical-radiobiology-of-proton-therapy-modeling-of-rbe
#12
B Jones
PURPOSE: To better estimate relative biological effectiveness (RBE) in therapeutic proton beams by using a modeled approach, in order to improve their clinical safety and effectiveness. INTRODUCTION: Concerns exist about the 1.1 RBE used in proton therapy, since it may lead to unintentional over- and under-dosage in patients and so lead to unexpected clinical outcomes. Late reacting normal tissues (with low α/β values), might be overdosed if RBE >1.1; very radiosensitive tumors (with high α/β), might be under-dosed if RBE <1...
August 18, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28820287/comparison-of-pet-and-ct-radiomics-for-prediction-of-local-tumor-control-in-head-and-neck-squamous-cell-carcinoma
#13
Marta Bogowicz, Oliver Riesterer, Luisa Sabrina Stark, Gabriela Studer, Jan Unkelbach, Matthias Guckenberger, Stephanie Tanadini-Lang
PURPOSE: An association between radiomic features extracted from CT and local tumor control in the head and neck squamous cell carcinoma (HNSCC) has been shown. This study investigated the value of pretreatment functional imaging (18F-FDG PET) radiomics for modeling of local tumor control. MATERIAL AND METHODS: Data from HNSCC patients (n = 121) treated with definitive radiochemotherapy were used for model training. In total, 569 radiomic features were extracted from both contrast-enhanced CT and 18F-FDG PET images in the primary tumor region...
August 18, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28820285/oligometastatic-cancer-stereotactic-ablative-radiotherapy-for-patients-affected-by-isolated-body-metastasis
#14
Andrea Lancia, Gianluca Ingrosso, Alessandra Carosi, Luana Di Murro, Emilia Giudice, Sara Cicchetti, Pasquale Morelli, Daniela di Cristino, Claudia Bruni, Alessandra Murgia, Alessandro Cancelli, Irene Turturici, Anjali Iadevaia, Elisabetta Ponti, Riccardo Santoni
BACKGROUND: To evaluate the outcome of patients affected by a single isolated body metastasis treated with stereotactic body radiotherapy (SBRT). MATERIAL AND METHODS: Seven-eight patients were treated with SBRT for isolated body metastasis. The most frequent primary tumor was prostate cancer (28.2%), followed by colorectal cancer (23.1%) and lung cancer (20.5%). Median age at diagnosis of oligometastatic disease was 70 years (range 47-88). Median Karnofsky Performance Status (KPS) was 90 (range 70-100)...
August 18, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28816079/the-applicability-of-the-translated-edmonton-symptom-assessment-system-revised-esas-r-in-swedish-palliative-care
#15
Carina Lundh Hagelin, Anna Klarare, Carl Johan Fürst
No abstract text is available yet for this article.
August 17, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28816074/prostate-specific-antigen-after-salvage-radiotherapy-for-postprostatectomy-biochemical-recurrence-predicts-long-term-outcome-including-overall-survival
#16
Detlef Bartkowiak, Reinhard Thamm, Dirk Bottke, Alessandra Siegmann, Dirk Böhmer, Volker Budach, Thomas Wiegel
BACKGROUND: For patients with recurrent prostate cancer after radical prostatectomy (RP), salvage radiotherapy (SRT) is a second chance of cure. However, depending on risk factors, 40-70% of the patients experience further progression. With a focus on the pre- and post-SRT serum level of the prostate-specific antigen (PSA), we assessed the determinants of the long-term outcome after SRT. PATIENT AND METHODS: Between 1997 and 2011, 464 patients received 3D-conformal SRT with median 66...
August 17, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28816072/calcium-electroporation-for-treatment-of-cutaneous-metastases-a-randomized-double-blinded-phase-ii-study-comparing-the-effect-of-calcium-electroporation-with-electrochemotherapy
#17
H Falk, L W Matthiessen, G Wooler, J Gehl
BACKGROUND: Calcium electroporation is a novel anticancer treatment, which utilizes high voltage pulses to permeabilize cell membranes and expose the cell to supraphysiological doses of calcium. Preclinical studies on calcium electroporation have shown strikingly high tumor response with cell necrosis. Calcium electroporation builds on the treatment electrochemotherapy, where chemotherapeutic drugs, mostly bleomycin, are internalized by electroporation. This double-blinded randomized study compared calcium electroporation to electrochemotherapy in terms of objective response measured 6 months after treatment...
August 17, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28812409/tumor-reduction-and-symptom-relief-after-electrochemotherapy-in-a-patient-with-aggressive-fibromatosis-a-case-report
#18
Joanna Vitfell-Rasmussen, Rikke Mulvad Sandvik, Karin Dahlstrøm, Gina Al-Farra, Anders Krarup-Hansen, Julie Gehl
No abstract text is available yet for this article.
August 16, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28799431/vulvar-cancer-in-germany-increase-in-incidence-and-change-in-tumour-biological-characteristics-from-1974-to-2013
#19
Bernd Holleczek, Jalid Sehouli, Jana Barinoff
BACKGROUND: The incidence of vulvar cancer in Germany is increasing. Moreover, gynaecological oncologists reported observing increasing numbers of women presenting with small tumours. The aim of the present study is to validate this observation on a population level and to extend available incidence data. MATERIAL AND METHODS: Data from the population-based Saarland Cancer Registry were used and included 1136 women diagnosed with invasive vulvar cancer (ICD-9 codes: 181...
August 11, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28780900/results-from-a-clinical-trial-evaluating-the-efficacy-of-real-time-body-surface-visual-feedback-in-reducing-patient-motion-during-lung-cancer-radiotherapy
#20
Gareth J Price, Corinne Faivre-Finn, Julia Stratford, Sheena Chauhan, Michelle Bewley, Laura Clarke, Corinne N Johnson, Christopher J Moore
INTRODUCTION: Optical surface measurement devices are a maturing technology in radiotherapy. The challenge for such devices is to demonstrate how they can improve clinical care. We present results from a phase 1 clinical trial designed to test the hypothesis that if presented with live data from a novel optical measurement device, showing their deviation from an ideal radiotherapy treatment position, patients will be able to better control their motion and increase their geometrical conformance...
August 7, 2017: Acta Oncologica
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