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Acta Oncologica

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https://www.readbyqxmd.com/read/29451409/temporal-trends-in-incidence-and-outcome-of-hydatidiform-mole-a-retrospective-cohort-study
#1
Urika Joneborg, Yasin Folkvaljon, Nikos Papadogiannakis, Mats Lambe, Lena Marions
BACKGROUND: Reported incidence rates of hydatidiform mole (HM) show wide geographic and temporal variations, making reliable international comparisons difficult. The aim of the current study was to examine temporal trends in the incidence of HM and post-molar gestational trophoblastic neoplasia (GTN) in Stockholm County. MATERIAL AND METHODS: Data of all women with a diagnosis of HM in Stockholm County 1991-2010 was collected. The incidence of HM was assessed both in relation to number of births and viable conceptions (births and pregnancy terminations)...
February 16, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29451406/cancer-costs-and-outcomes-for-common-cancer-sites-in-the-finnish-population-between-2009-2014
#2
Paulus Torkki, Riikka-Leena Leskelä, Miika Linna, Suvi Mäklin, Jukka-Pekka Mecklin, Petri Bono, Vesa Kataja, Sakari Karjalainen
BACKGROUND: The cost of cancer and outcomes of cancer care have been discussed a lot since cancer represents 3-6% of total healthcare costs and cost estimations have indicated growing costs. There are studies considering the cost of all cancers, but studies focusing on the cost of disease and outcomes in most common cancer sites are limited. The objective of this study was to analyze the development of the costs and outcomes in Finland between 2009 and 2014 per cancer site. METHODS: The National cost, episode and outcomes data were obtained from the National register databases based on International Statistical Classification of Diseases (ICD)-10 diagnosis codes...
February 16, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29451070/confounders-other-than-comorbidity-explain-survival-differences-in-danish-and-swedish-ovarian-cancer-patients-a-comparative-cohort-study
#3
Mette Calundann Noer, Pia Leandersson, Torbjørn Paulsen, Susanne Rosthøj, Sofie Leisby Antonsen, Christer Borgfeldt, Claus Høgdall
OBJECTIVE: Danish ovarian cancer (OC) patients have previously been found to have worse prognosis than Swedish patients, and comorbidity has been suggested as a possible explanation for this survival difference. We aimed to investigate the prognostic impact of comorbidity in surgically treated OC patients in Denmark and Sweden. METHODS: This comparative cohort study was based on data from 3118 surgically treated OC patients diagnosed in 2012-2015. The Swedish subcohort (n = 1472) was identified through the Swedish National Quality Register of Gynecological Surgery, whereas the Danish subcohort (n = 1646) originated from the Danish Gynecological Cancer Database...
February 16, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29451059/-oncokompas-a-web-based-self-management-application-to-support-patient-activation-and-optimal-supportive-care-a-feasibility-study-among-breast-cancer-survivors
#4
Heleen C Melissant, Irma M Verdonck-de Leeuw, Birgit I Lissenberg-Witte, Inge R Konings, Pim Cuijpers, Cornelia F Van Uden-Kraan
BACKGROUND: Cancer survivors have to deal with symptoms related to cancer and its treatment. In Oncokompas, cancer survivors monitor their quality of life by completing patient reported outcome measures (PROMs), followed by personalized feedback, self-care advice, and supportive care options to stimulate patient activation. The aim of this study was to investigate feasibility and pretest-posttest differences of Oncokompas including a newly developed breast cancer (BC) module among BC survivors...
February 16, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29447088/increasing-incidence-and-survival-of-head-and-neck-cancers-in-denmark-a-nation-wide-study-from-1980-to-2014
#5
Kathrine Kronberg Jakobsen, Christian Grønhøj, David Hebbelstrup Jensen, Kirstine Kim Schmidt Karnov, Tina Klitmøller Agander, Lena Specht, Christian von Buchwald
BACKGROUND: The purpose of the study was to determine trends in age-adjusted incidence rates (AAIR) and survival probability in head and neck cancers (HNCs) in the Danish population from 1980 to 2014. MATERIAL AND METHODS: All patients registered with HNC in the nationwide Danish Cancer Registry from 1980 to 2014 were included. We evaluated the AAIR per 100,000 and the average annual percent change (AAPC). The relative survival probability at 5 years was calculated in relation to gender, anatomical location and histology, and we constructed age-period-cohort models of incidence...
February 15, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29447047/prospective-comparative-study-of-18-f-sodium-fluoride-pet-ct-and-planar-bone-scintigraphy-for-treatment-response-assessment-of-bone-metastases-in-patients-with-prostate-cancer
#6
Randi Fuglsang Fonager, Helle Damgaard Zacho, Niels Christian Langkilde, Joan Fledelius, June Anita Ejlersen, Helle Westergreen Hendel, Christian Haarmark, Mette Moe, Jesper Carl Mortensen, Mads Ryø Jochumsen, Lars Jelstrup Petersen
AIM: To compare 18 F-sodium fluoride positron emission tomography/computed tomography (NaF PET/CT) and 99m Tc-labelled diphosphonate bone scan (BS) for the monitoring of bone metastases in patients with prostate cancer undergoing anti-cancer treatment. MATERIAL AND METHODS: Data from 64 patients with prostate cancer were included. The patients received androgen-deprivation therapy (ADT), next-generation hormonal therapy (NGH) or chemotherapy. The patients had a baseline scan and 1-3 subsequent scans during six months of treatment...
February 15, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29447028/elastase-as-a-potential-biomarker-for-radiation-induced-gut-wall-injury-of-the-distal-bowel-in-an-experimental-mouse-model
#7
Fei Sjöberg, Dilip Kumar Malipatlolla, Piyush Patel, Ulrica Wilderäng, Marie Kalm, Gunnar Steineck, Cecilia Bull
BACKGROUND AND PURPOSE: Traditionally, elastase has been used to study exocrine activity of the pancreas in patients with chronic pancreatitis and cystic fibrosis, and calprotectin as a marker for gut-wall inflammation in patients with inflammatory bowel disease. The aim of the study was to find out whether elastase and calprotectin could be used as inflammatory markers for radiation-induced gut wall injury of the distal bowel. MATERIAL AND METHODS: Adult male mice were exposed to two, three, or four fractions of 6 Gy or 8 Gy irradiation to the sigmoid and rectum of the large bowel, using a linear accelerator...
February 15, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29447025/anal-sphincter-dysfunction-in-patients-treated-with-primary-radiotherapy-for-anal-cancer-a-study-with-the-functional-lumen-imaging-probe
#8
Susanne Haas, Pia Faaborg, Donghua Liao, Søren Laurberg, Hans Gregersen, Lilly Lundby, Peter Christensen, Klaus Krogh
BACKGROUND: Sphincter-sparing radiotherapy or chemoradiation are standard treatments for patients with anal cancer. The ultimate treatment goal is full recovery from anal cancer with preserved anorectal function. Unfortunately, long-term survivors often suffer from severe anorectal symptoms. The aim of the present study was to characterize changes in anorectal physiology after radiotherapy for anal cancer. METHOD: We included 13 patients (10 women, age 63.4 ± 1...
February 15, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29419331/-icorg-05-03-prospective-randomized-non-inferiority-phase-iii-trial-comparing-two-radiation-schedules-in-malignant-spinal-cord-compression-not-proceeding-with-surgical-decompression-the-quality-of-life-analysis
#9
K A Lee, M Dunne, C Small, P J Kelly, O McArdle, J O'Sullivan, D Hacking, M Pomeroy, J Armstrong, M Moriarty, A Clayton-Lea, I Parker, C D Collins, P Thirion
BACKGROUND: The optimal primary external beam radiation therapy (EBRT) radiation schedule for malignant epidural spinal cord compression (MSCC) remains to be determined. The ICORG 05-03 trial assessed if a 10 Gy single fraction radiation schedule was not inferior to one with 20 Gray (Gy) in five daily fractions, in terms of functional motor outcome, for the treatment of MSCC in patients not proceeding with surgical decompression. This article reports on two of the secondary endpoints, Quality of life (QoL), assessed according to the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) version 3...
February 8, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29405785/clinical-estimation-of-%C3%AE-%C3%AE-values-for-prostate-cancer-from-isoeffective-phase-iii-randomized-trials-with-moderately-hypofractionated-radiotherapy
#10
Niloy R Datta, Emanuel Stutz, Susanne Rogers, Stephan Bodis
BACKGROUND: The α/β values for prostate cancer (PCa) are usually assumed to be low (1.0-1.8 Gy). This study estimated the α/β values of PCa from phase III randomized trials of conventional (CRT) versus hypofractionated (HRT) external beam radiotherapy (RT), reported as isoeffective in terms of their 5-year biochemical (BF) or biochemical and/or clinical failure (BCF) rates. MATERIAL AND METHODS: The α/β for each trial was estimated from the equivalent biological effective doses using the linear-quadratic model for each of their HRT and CRT schedules...
February 6, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29392966/the-pliant-trial-gives-trustworthy-data
#11
Bengt Glimelius, Jan Kowalski, Jacques Näsström
No abstract text is available yet for this article.
February 2, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29392960/a-randomized-phase-ii-trial-of-interleukin-2-and-interferon-%C3%AE-plus-bevacizumab-versus-interleukin-2-and-interferon-%C3%AE-in-metastatic-renal-cell-carcinoma-mrcc-results-from-the-danish-renal-cancer-group-darenca-study-1
#12
Frede Donskov, Niels Viggo Jensen, Torben Smidt-Hansen, Line Brøndum, Poul Geertsen
BACKGROUND: Interleukin-2 (IL2)-based immunotherapy is curative for a small subset of patients with metastatic renal-cell carcinoma (mRCC). Preclinical data suggests that bevacizumab (BEV), a humanized anti-VEGF monoclonal antibody, has potential immunomodulatory effects by permitting efficient natural killer (NK) cell-mediated killing and by reverting immune suppression. PATIENT AND METHODS: We performed a randomized phase II study comparing IL2/IFN (interferon)/BEV with IL2/IFN in favourable/intermediate-risk mRCC patients...
February 2, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29388498/can-carcinoembryonic-antigen-replace-computed-tomography-in-response-evaluation-of-metastatic-colorectal-cancer
#13
Kethe Hermunen, Eila Lantto, Tuija Poussa, Caj Haglund, Pia Österlund
INTRODUCTION: Response Evaluation Criteria in Solid Tumours (RECISTs 1.1) define computed tomography (CT) as the gold standard in response evaluation of patients with metastatic colorectal cancer (mCRC) who are undergoing chemotherapy. The aim of this study was to evaluate whether carcinoembryonic antigen (CEA), which is cheaper and easier to perform, can replace repeated CT. MATERIAL AND METHODS: The study included 66 patients with non-resectable mCRC participating in a phase I-II study...
February 1, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29384420/hearing-loss-before-and-after-cisplatin-based-chemotherapy-in-testicular-cancer-survivors-a-longitudinal-study
#14
Hege S Haugnes, Niels Christian Stenklev, Marianne Brydøy, Olav Dahl, Tom Wilsgaard, Einar Laukli, Sophie D Fosså
BACKGROUND: Hearing loss is a well-known long-term effect after cisplatin-based chemotherapy (CBCT) in testicular cancer survivors (TCS), but longitudinal data are sparse. We evaluate hearing loss and the impact of age in TCS treated with CBCT in this longitudinal study. MATERIAL AND METHODS: Forty-six TCS treated with CBCT 1980-1994 with audiograms (0.25-8 kHz) pre-chemotherapy (PRE) and at a follow-up survey (SURV) after median 10 years were included (cases)...
January 31, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29384034/development-of-pulmonary-tuberculosis-following-treatment-with-anti-pd-1-for-non-small-cell-lung-cancer
#15
Kristian Hastoft Jensen, Gitte Persson, Anna-Louise Bondgaard, Mette Pøhl
No abstract text is available yet for this article.
January 31, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29383974/is-the-accuracy-of-preoperative-mri-stage-in-rectal-adenocarcinoma-influenced-by-tumour-height
#16
Laurids Østergaard Poulsen, Mette Karen Yilmaz, Lars Oddershede, Martin Bøgsted, Gitte Holt, Mikkel Eld, Ken Ljungmann, Ursula Gerda Falkmer
AIM: To our knowledge, no prior studies have addressed the possible effects of tumour height on the accuracy of preoperative magnetic resonance imaging (MRI)-based staging relative to postoperative histopathological assessments in patients with adenocarcinoma of the rectum (RC). This study aimed to investigate whether the accuracy of preoperative MRI stage in RC is influenced by tumour height. METHODS: A total of 489 consecutive RC patients scheduled for curative treatment between 2009 and 2013 were included...
January 31, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29383969/contouring-pudendal-nerves
#17
Gunnar Steineck, Cecilia Bull, Fei Sjöberg
No abstract text is available yet for this article.
January 31, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29381126/the-evolving-management-of-small-bowel-adenocarcinoma
#18
Eelco de Bree, Koen P Rovers, Dimitris Stamatiou, John Souglakos, Dimosthenis Michelakis, Ignace H de Hingh
BACKGROUND: Small bowel adenocarcinoma (SBA) is rare despite the fact that the small bowel represents the longest part and has the largest surface of all alimentary tract sections. Its incidence is 50-fold lower than that of colorectal carcinoma. It is often diagnosed at an advanced stage due to atypical and late symptoms, its low index of suspicion, difficult endoscopic access and poor detection by radiological imaging, resulting in impaired outcome. Due to its rarity and being molecularly a unique intestinal cancer, data regarding its optimal management are relatively sparse...
January 30, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29380640/associations-between-primary-tumor-ras-braf-and-pik3ca-mutation-status-and-metastatic-site-in-patients-with-chemo-resistant-metastatic-colorectal-cancer
#19
Troels Dreier Christensen, Jesper Andreas Palshof, Finn Ole Larsen, Tim Svenstrup Poulsen, Estrid Høgdall, Per Pfeiffer, Benny Vittrup Jensen, Mette Karen Yilmaz, Dorte Nielsen
BACKGROUND: Several studies have investigated correlations between metastatic pattern and mutation status in patients with colorectal cancer (CRC). However, most of the studies were small and heterogeneously designed and further research is needed to confirm previous results. In this study, we investigated the association between RAS (KRAS or NRAS), BRAF, PIK3CA mutations and metastatic pattern in patients with metastatic (m) CRC. MATERIAL AND METHODS: This study reviewed Danish biobank and database of patients with mCRC who received cetuximab and irinotecan, independent of RAS mutation status, after fluoropyrimidine, oxaliplatin and irinotecan treatment failure...
January 30, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29374996/bone-mineral-density-is-compromised-in-very-long-term-survivors-of-irradiated-childhood-brain-tumor
#20
Tiina M Remes, Pekka M Arikoski, Päivi M Lähteenmäki, Mikko O Arola, Tytti M-L Pokka, V Pekka Riikonen, Kirsti H Sirkiä, Heikki M J Rantala, Arja H Harila-Saari, Marja K Ojaniemi
INTRODUCTION: The increase in the number of childhood brain tumor survivors warrants detailed research to increase our knowledge regarding the possible physical and psychosocial adverse outcomes of tumor and tumor therapy. The aim of this study was to evaluate the current bone health by measuring the bone mineral density (BMD) in irradiated, adult long-term survivors of childhood brain tumors. MATERIAL AND METHODS: We studied a national cohort of 74 adult survivors of childhood brain tumors treated with irradiation in Finland between 1970 and 2008...
January 27, 2018: Acta Oncologica
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