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Transfusion Medicine Reviews

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https://www.readbyqxmd.com/read/29921477/quality-of-evidence-based-guidelines-for-transfusion-of-red-blood-cells-and-plasma-a-systematic-review
#1
REVIEW
Katerina Pavenski, Simon Stanworth, Mark Fung, Erica M Wood, Joanne Pink, Michael F Murphy, Heather Hume, Susan Nahirniak, Kathryn E Webert, Susano Tanael, Denise Landry, Nadine Shehata
Many transfusion guidelines are available, but little appraisal of their quality has been undertaken. The quality of guidelines may potentially influence adoption. Our aim was to determine the quality of evidence-based transfusion guidelines (EBG) for red cells and plasma, using the Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument, and assess duplication and consistency of recommendations. MEDLINE and EMBASE were systematically searched for EBG from 2005 to June 3, 2016. Citations were reviewed for inclusion in duplicate...
June 1, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29891441/adverse-events-associated-with-infusion-of-hematopoietic-stem-cell-products-a-prospective-and-multicenter-surveillance-study
#2
REVIEW
Kazuhiko Ikeda, Hitoshi Ohto, Yoshiki Okuyama, Minami Yamada-Fujiwara, Heiwa Kanamori, Shin-Ichiro Fujiwara, Kazuo Muroi, Takehiko Mori, Kinuyo Kasama, Tohru Iseki, Tokiko Nagamura-Inoue, Nobuharu Fujii, Takashi Ashida, Kazuaki Kameda, Junya Kanda, Asao Hirose, Tsutomu Takahashi, Kazuhiro Nagai, Keiji Minakawa, Ryuji Tanosaki
Adverse events (AEs) associated with blood transfusions, including component-specific red cell, platelet, and plasma products, have been extensively surveyed. In contrast, surveillance of AEs associated with hematopoietic stem cell (HSC) products in HSC transplantation (HSCT) has been less rigorous, even though HSC products include a diversity of immature and mature hematopoietic cells, substantial plasma, and dimethyl sulfoxide (DMSO) in the case of cryopreserved HSC products. HSC infusion-related AEs have been attributed to DMSO toxicity, but AEs associated with the infusion of noncryopreserved HSC products are not uncommon...
June 1, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29934136/transfusion-management-of-obstetric-hemorrhage
#3
REVIEW
Kerry L O'Brien, Scott A Shainker, Evelyn L Lockhart
Obstetric hemorrhage is one of the leading, as well as one of the most treatable, causes of maternal morbidity and mortality worldwide. As obstetric hemorrhage often occurs in patients without risk factors, there is virtually unanimous agreement from obstetric professional societies to establish obstetric hemorrhage protocols in anticipation of these emergencies. These protocols involve multidisciplinary teams in which the transfusion service plays an essential and vital role. This manuscript will examine the epidemiology of obstetric hemorrhage, risk factors that may be present, and recommendations for these protocols, with a focus on massive transfusion protocols, laboratory testing, cell salvage and use of pharmacologic adjuvant therapy including tranexamic acid and factor concentrates...
May 31, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29884513/acquired-antibodies-to-%C3%AE-iib%C3%AE-3-in-glanzmann-thrombasthenia-from-transfusion-and-pregnancy-to-bone-marrow-transplants-and-beyond
#4
REVIEW
Alan T Nurden
Patients with the inherited bleeding disorder Glanzmann thrombasthenia (GT) possess platelets that lack αIIbβ3 integrin and fail to aggregate, and have moderate to severe mucocutaneous bleeding. Many become refractory to platelet transfusions due to the formation of isoantibodies to αIIbβ3 with the rapid elimination of donor platelets and/or a block of function. Epitope characterization has shown isoantibodies to be polyclonal and to recognize different epitopes on the integrin with β3 a major site and αvβ3 on endothelial and vascular cells a newly recognized target...
May 23, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29751949/platelet-storage-lesions-what-more-do-we-know-now
#5
REVIEW
Monica Suet Ying Ng, John-Paul Tung, John Francis Fraser
Platelet concentrate (PC) transfusions are a lifesaving adjunct to control and prevent bleeding in cancer, hematologic, surgical, and trauma patients. Platelet concentrate availability and safety are limited by the development of platelet storage lesions (PSLs) and risk of bacterial contamination. Platelet storage lesions are a series of biochemical, structural, and functional changes that occur from blood collection to transfusion. Understanding of PSLs is key for devising interventions that prolong PC shelf life to improve PC access and wastage...
April 17, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29540278/the-gerbich-blood-group-system-old-knowledge-new-importance
#6
REVIEW
Ewa Jaskiewicz, Thierry Peyrard, Radoslaw Kaczmarek, Agata Zerka, Marlena Jodlowska, Marcin Czerwinski
Antigens of the Gerbich blood group system are expressed on glycophorin C (GPC) and glycophorin D (GPD), minor sialoglycoproteins of human erythrocytes. GPC and GPD help maintain erythrocyte shape of and contributes to the stability of its membrane. There are six high-prevalence Gerbich antigens: Ge2, Ge3, Ge4, GEPL (GE10), GEAT (GE11), GETI (GE12) and five low-prevalence Gerbich antigens: Wb (GE5), Lsa (GE6), Ana (GE7), Dha (GE8), GEIS (GE9). Some Gerbich antigens (Ge4, Wb, Dha , GEAT) are expressed only on GPC, two (Ge2, Ana ) are expressed only on GPD, while others (Ge3, Lsa , GEIS, GEPL, GETI) are expressed on both GPC and GPD...
April 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29526337/effect-of-age-of-red-cells-for-transfusion-on-patient-outcomes-a-systematic-review-and-meta-analysis
#7
REVIEW
Zoe K McQuilten, Craig J French, Alistair Nichol, Alisa Higgins, David J Cooper
Longer storage duration of red blood cell (RBC) units prior to transfusion has been associated with worse outcomes in observational studies. We performed a systematic review, including recently published randomized trials, to determine if storage age of RBCs is associated with mortality, morbidity or adverse events in patients. Searches were performed up to 21st July 2017 in Medline (OvidSP), 20 July in EMBASE (OvidSP) and June 2017 in Cochrane Library. Eligible studies were randomized controlled trials comparing transfusion of fresher or freshest available with older or standard issue RBCs...
April 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29426670/simulation-based-transfusion-education-for-medical-students
#8
LETTER
Ariela L Marshall, Rajiv K Pruthi, Justin D Kreuter
No abstract text is available yet for this article.
April 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29395602/an-observational-study-of-3-different-transfusion-medicine-teaching-methods-for-medical-students
#9
REVIEW
Mojca Remskar Konia, Martina Richtsfeld, Andrew D Johnson, Michael Lougee, Claudia Cohn, Shanna Morgan
Knowledge deficits of transfusion medicine are prevalent among learners and practicing physicians. In the past, the transfusion medicine community has thoughtfully defined the content of transfusion medicine curriculums through Transfusion Medicine Academic Award Group and The Academy of Clinical Laboratory Physicians and Scientists. The manner in which the curriculum should be delivered has been less carefully examined and defined. We completed an observational study in which we analyzed 3 different teaching techniques: in-person faculty-led simulation curriculum consisting of didactic session and simulation ("Simulation group"); hybrid education with a combination of online materials and short in-person simulation ("Hybrid group"); and online-only education module, which delivered the whole curricular content through a variety of online materials and videos ("Online-only group")...
April 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29157918/purpura-fulminans-mechanism-and-management-of-dysregulated-hemostasis
#10
REVIEW
Meaghan E Colling, Pavan K Bendapudi
Purpura fulminans (PF) is a highly thrombotic subtype of disseminated intravascular coagulation that can accompany severe bacterial, and more rarely, viral infections. PF is associated with an extremely high mortality rate, and patients often die of overwhelming multisystemic thrombosis rather than septic shock. Survivors typically experience amputation of involved extremities and significant scarring in affected areas. Despite the devastating clinical course associated with this hemostatic complication of infection, the mechanism of PF remains poorly understood...
April 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29126577/the-efficacy-of-postoperative-iron-therapy-in-improving-clinical-and-patient-centered-outcomes-following-surgery-a-systematic-review-and-meta-analysis
#11
REVIEW
Iris Perelman, Remington Winter, Lindsey Sikora, Guillaume Martel, Elianna Saidenberg, Dean Fergusson
Postoperative anemia is a common occurrence in surgical patients and leads to an increased risk for allogeneic blood transfusions. The efficacy of iron therapy in treating postoperative anemia has not been firmly established. The objective of this systematic review was to evaluate the efficacy of postoperative oral and intravenous (IV) iron therapy in increasing hemoglobin levels and improving patient outcomes following elective surgery. The databases Medline, EMBASE, CENTRAL, the Transfusion Evidence Library, and ClinicalTrials...
April 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29031409/a-study-of-the-pharmacokinetic-properties-and-the-in-vivo-kinetics-of-erythrocytes-loaded-with-dexamethasone-sodium-phosphate-in-healthy-volunteers
#12
REVIEW
Shodeinde A Coker, Zbigniew M Szczepiorkowski, Alan H Siegel, Antonio Ferrari, Giovanni Mambrini, Ravi Anand, Richard D Hartman, Luca Benatti, Larry J Dumont
The objectives of this 2-phase study were to elucidate pharmacokinetics (PK), in vivo 24-hour recovery, and red blood cell (RBC) survival properties of RBC-encapsulated dexamethasone sodium phosphate (DSP) prepared using the EryDex System (EDS). The 24-hour RBC recovery and T50 survival phase studied subjects were randomized to receive autologous RBCs loaded with either 15-20 mg DSP (Group 1A) or sham saline (Group 2A). Loaded RBCs were radiolabeled with 51-Cr, and the labeled RBCs were followed over time in vivo...
April 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29573905/autoimmune-hemolytic-anemia-aiha-following-allogeneic-hematopoietic-stem-cell-transplantation-hsct-a-retrospective-analysis-and-a-proposal-of-treatment-on-behalf-of-the-grupo-espa%C3%A3-ol-de-trasplante-de-medula-osea-en-ni%C3%A3-os-getmon-and-the-grupo-espa%C3%A3-ol-de-trasplante
#13
REVIEW
Marta González-Vicent, Jaime Sanz, José Luis Fuster, Joan Cid, Cristina Díaz de Heredia, Daniel Morillo, José María Fernández, Antonia Pascual, Isabel Badell, David Serrano, Laura Fox, Javier de la Serna, Ana Benito, José Miguel Couselo, Blanca Molina, Miguel Ángel Díaz, Miguel Ángel Sanz
Autoimmune hemolytic anemia (AIHA) is a complication of allogeneic hematopoietic stem cell transplantation (HSCT) associated with poor outcome. However, an optimal therapeutic approach is lacking. Between 2000 and 2015, 4099 allogeneic HSCT were performed in eight pediatric centers of the Grupo Español De Trasplante de Medula Osea en Niños (GETMON) and six adult centers of the Grupo Español de Trasplante Hematopoyetico (GETH). Sixty cases of AIHA were registered with a cumulative incidence of 1.5% occurring at a median of 6 months after HSCT...
March 3, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29567052/the-efficacy-and-safety-of-topical-tranexamic-acid-a-systematic-review-and-meta-analysis
#14
REVIEW
Joshua Montroy, Brian Hutton, Preveshen Moodley, Nicholas A Fergusson, Wei Cheng, Alan Tinmouth, Luke T Lavallée, Dean A Fergusson, Rodney H Breau
Tranexamic acid (TXA) is an effective hemostatic agent used for the reduction of blood loss and transfusion. However, the safety profile of TXA remains in question due to a potential increased risk of venous thromboembolism. By applying TXA topically as opposed to intravenously, systemic absorption may be reduced and unwanted side-effects mitigated. The objective of our review is to investigate the efficacy and safety of topically applied tranexamic acid compared to both placebo, and the intravenous administration...
February 19, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29126578/the-earliest-blood-transfusions-in-17th-century-in-italy-1667-1668
#15
REVIEW
Silvia Marinozzi, Valentina Gazzaniga, Silvia Iorio
Historical accounts of the earliest experiments in blood transfusion celebrate work done in France and England in 1667 to 1668. Less attention has been given to pioneering experiments conducted at the same period in Italy. We review records of the first blood transfusion experiments conducted in 17th century Italy. Using original source documents, we provide details of early experiments focusing on the identity of early researchers, their instruments, and techniques. Accounts of the period describe animal-to-animal, animal-to-human, and human-to-human transfusions...
January 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29017820/possible-utility-of-the-basophil-activation-test-for-the-analysis-of-mechanisms-involved-in-allergic-transfusion-reactions
#16
REVIEW
Fumiya Hirayama, Kazuta Yasui, Nobuki Matsuyama, Ikue Okamura-Shiki
Allergic transfusion reactions (ATRs) are the most common adverse reactions occurring during transfusion of blood components. Although most reactions are mild and involve cutaneous manifestations, severe ATRs including life-threatening anaphylaxis may also occur. The mechanisms of ATRs are largely unknown because they have not been well studied. One of the reasons for this may be the absence of a standard assay system for investigating these processes. Basophils and/or mast cells are key effector cells in immediate-type allergic reactions...
January 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28988603/exploring-donor-and-product-factors-and-their-impact-on-red-cell-post-transfusion-outcomes
#17
REVIEW
Shuoyan Ning, Nancy M Heddle, Jason P Acker
The impact of donor characteristics, red cell age, and red cell processing methods on recipient outcomes is an emerging area of research. Knowledge generated from exploring this transfusion continuum has the potential to change the way donors are selected and how donations are processed and stored with important clinical and operational impact. Recently, donor characteristics including age, gender, donation frequency, genetics, and ethnicity have been shown to affect product quality and possibly recipient outcomes...
January 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28864336/analysis-of-transfusion-related-acute-lung-injury-and-possible-transfusion-related-acute-lung-injury-reported-to-the-french-hemovigilance-network-from-2007-to-2013
#18
REVIEW
Georges Andreu, Karim Boudjedir, Jean-Yves Muller, Elodie Pouchol, Yves Ozier, Guillaume Fevre, Chantal Gautreau, Jean-François Quaranta, Christian Drouet, Claire Rieux, Paul-Michel Mertes, Benoit Clavier, Monique Carlier, Imad Sandid
Using the French Hemovigilance Network database from 2007 to 2013, we provide information on demographics, incidence, and risk factors of reported transfusion-related acute lung injury (TRALI) and possible TRALI, analyze TRALI mitigation efforts for fresh frozen plasma and platelet concentrates, and consider the impact of platelet additive solutions on TRALI incidence. We applied the Toronto consensus conference definitions for TRALI and possible TRALI. Two TRALI subgroups were considered: "antibody positive" when a donor has human leukocyte antigen (class I or II) and/or human neutrophil antigen antibodies and the recipient has cognate antigen, and "antibody negative" when immunological investigation is negative or not done...
January 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28843515/estimating-tanzania-s-national-met-and-unmet-blood-demand-from-a-survey-of-a-representative-sample-of-hospitals
#19
REVIEW
Bakary Drammeh, Anindya De, Naomi Bock, Sonal Pathak, Abdu Juma, Regina Kutaga, Mwanakheir Mahmoud, Dunstan Haule, Senga Sembucha, Karen Chang, Efespa Nkya, Matthew Kuehnert, Anthony A Marfin
Estimating blood demand to determine collection goals challenges many low-income countries. We sampled Tanzanian hospitals to estimate national blood demand. A representative sample based on probability proportional to size sampling of 42 of 273 (15%) Tanzanian transfusing hospitals was selected. Blood bank registers, patient medical records, and blood component disposition records were reviewed prospectively from June to September 2013 to determine the number of components requested and the number and proportion issued, not issued due to nonavailability, and not issued for other reasons...
January 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28821369/erratum-to-emerging-infectious-diseases-and-blood-safety-modeling-the-transfusion-transmission-risk-transfusion-medicine-reviews-31-3-2017-154-164
#20
Philip Kiely, Manoj Gambhir, Allen C Cheng, Zoe K McQuilten, Clive R Seed, Erica M Wood
No abstract text is available yet for this article.
January 2018: Transfusion Medicine Reviews
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